Molecular interactions between indole derivatives and 1,2-di-oleoyl-sn-glycero-3-phosphocholine (DOPC) were studied using a Nima Langmuir-Blodgett (LB) trough. A 0.25 M phosphate buffer sub-phase was used with a physiological pH range of 7.31-7.48. The air-phosphate buffer interface was examined at room temperature. Constant ionic strength was maintained by 0.100 M potassium chloride (KCl). Two different indole derivatives were used, indole and tryptophan, in concentrations of 3.0 uM and 5.0 uM. It is evident when examining the isotherms that the DOPC monolayer is expanded in the presence of indole derivatives, as the area per molecule was increased by 0.02nm2/molecule ...
293392741 - EP 1100780 A1 2001-05-23 - 2,3,3a,4,9,9a-HEXAHYDRO-8-HYDROXY-1H-BENZ[F]INDOLES, A METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS MEDICAMENTS - [origin: DE19834714A1] The application relates to substituted 2,3,3a,4,9,9a hexahydro-8-hydroxy-1H-benz[f]indole derivatives, to a method for the production thereof, and to their use as medicaments. The inventive indole derivatives correspond to general formula (1).[origin: DE19834714A1] The application relates to substituted 2,3,3a,4,9,9a hexahydro-8-hydroxy-1H-benz[f]indole derivatives, to a method for the production thereof, and to their use as medicaments. The inventive indole derivatives correspond to general formula (1).
1. An (aza)indole derivative represented by the general formula: ##STR00412## wherein T represents nitro, cyano or trifluoromethyl; ring J represents an aryl ring or a heteroaryl ring; Q represents carboxy, lower alkoxycarbonyl, carbamoyl, mono(di)(lower alkyl)carbamoyl, sulfo, sulfamoyl or 5-tetrazolyl; Y represents a hydrogen atom, amino, a halogen atom, nitro, optionally substituted lower alkyl or optionally substituted lower alkoxy with the proviso that two or more Y optionally exist on ring J and these Y are optionally the same or different from each other; X1, X2 and X3 independently represent CR2 or N with the proviso that all of X1, X2 and X3 do not represent N at the same time, and when two or more R2 exist, these R2 are optionally the same or different from each other; and R1 and R2 independently represent a halogen atom, cyano, perfluoro(lower alkyl), -AA, -A-D-E-G or --N(-D-E-G)2 with the proviso that two (-D-E-G) are optionally different from each other; in the formula, AA ...
Semantic Scholar extracted view of Catechol and indole derivatives in a transplantable islet-cell tumour of the golden hamster. by Lennart Cegrell et al.
1. A compound represented by Formula below, ##STR00021## wherein (1) R1 to R3 and X are the same or different, and each independently represents (1) a C.sub.6.about.C60 aryl group or a C.sub.5.about.C60 heterocyclic group substituted or unsubstituted with at least one selected from the group including hydrogen, a halogen group, a cyano group, a nitrile group, a C.sub.1.about.C60 alkyl group, a C.sub.1.about.C60 alkoxy group, a C.sub.1.about.C60 alkylamine group, a C.sub.1.about.C60 arylamine group, a C.sub.1.about.C60 alkylthiophene group, a C.sub.6.about.C60 arylthiophene group, a C.sub.2.about.C60 alkenyl group, a C.sub.2.about.C60 alkynyl group, a C.sub.3.about.C60 cycloalkyl group, a C.sub.6.about.C60 aryl group, a deuterium-substituted C.sub.6.about.C60 aryl group, a C.sub.8.about.C60 arylalkenyl group, a substituted or unsubstituted silane group, a substituted or unsubstituted boron group, a substituted or unsubstituted germanium group, and a substituted or unsubstituted C.sub.5.about.C60 ...
Principal Investigator:ISHIKURA Minoru, Project Period (FY):1997 - 1999, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Chemical pharmacy
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3,3′-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIMs antiangiogenic activity. We found that DIM can inhibit vascular endothelial growth factor (VEGF)-induced cell proliferation and DNA synthesis in human umbilical vascular endothelial cells (HUVECs). Consistent with this inhibition, VEGF-induced extracellular signal-regulated kinase (ERK1/2) phosphorylation was greatly reduced. However, VEGF receptor phosphorylation induced by VEGF was not affected by DIM, indicating that DIM does not exert a direct and specific effect on the tyrosine kinase activity of this receptor. Further studies showed that DIM had a similar inhibitory effect on ERK1/2 phosphorylation induced by a variety of growth factors. Furthermore, Ras-GTP content, which dramatically increased after HUVECs were ...
A series of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters (2) were synthesized and found to possess high affinity for the cocaine binding site in rat striatum. The p-chloro (2c) and p-iodo (2n) compounds, which were the most potent analogues prepared, were found to be 85 and 78 times more potent than (-)-cocaine. The p-bromo (2m) and p-methyl (2d) were also 56 and 60 times more potent than cocaine. QSAR and CoMFA studies were conducted to correlate binding affinity of the cocaine analogues with their structural features.
Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles.
Prenyl transfer reactions occur ubiquitously in nature and play an important role in primary and secondary metabolism in all domains of life. Prenylated secondary metabolites including indole alkaloids usually demonstrate improved biological and pharmacological activities and thus makes them to promising candidates for drug discovery and development. Important producers of such bioactive compounds are fungi of ascomycetes and bacteria of actinomycetes. The transfer reactions of a prenyl moiety from prenyl diphosphate, primarily dimethylallyl diphosphate (DMAPP), onto indole derivatives including tryptophan are mainly catalyzed in nature by the members of the dimethylallyltryptophan synthase (DMATS) superfamily. In the last years, remarkable progress has been achieved in their biochemical, molecular biological, and structural characterization, especially for DMATS enzymes from fungi. The major challenge of this thesis is to provide a better understanding of the catalytic features of these enzymes ...
Molecular interactions between indole derivatives and 1,2-di-oleoyl-sn-glycero-3-phosphocholine (DOPC) were studied using a Nima Langmuir-Blodgett (LB) trough. A 0.25 M phosphate buffer sub-phase was used with a physiological ...
VELASCO-BEJARANO, Benjamín et al. Diindolylmethane Derivatives as Apoptosis Inductors in L5178y Cells. J. Mex. Chem. Soc [online]. 2008, vol.52, n.3, pp.224-228. ISSN 1870-249X.. Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitu-moral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.. Palabras clave : DIM derivatives; apoptosis; cytotoxic effects; L5178Y cells. ...
3-Methyl-7-azaindole 5654-93-3 NMR spectrum, 3-Methyl-7-azaindole H-NMR spectral analysis, 3-Methyl-7-azaindole C-NMR spectral analysis ect.
TY - JOUR. T1 - A survey of core replacements in indole-based HIV-1 attachment inhibitors. AU - Wang, Tao. AU - Wallace, Owen B.. AU - Zhang, Zhongxing. AU - Fang, Haiquan. AU - Yang, Zhong. AU - Robinson, Brett A.. AU - Spicer, Timothy P.. AU - Gong, Yi Fei. AU - Blair, Wade S.. AU - Shi, Pei-Yong. AU - Lin, Pin Fang. AU - Deshpande, Milind. AU - Meanwell, Nicholas A.. AU - Kadow, John F.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Indole- and azaindole-based glyoxylyl amide derivatives have been described as HIV-1 attachment inhibitors (AIs) that act by blocking the interaction between the viral gp120 coat protein and the human host cell CD4 receptor. As part of an effort to more deeply understand the role of the indole/azaindole heterocycle in the expression of antiviral activity, a survey of potential replacements was conducted using parallel synthesis methodology. The design and optimization was guided by a simple 2-dimensional overlay based on an overall planar topography between the ...
Disclosed is a novel, flame retarded, non-blooming nylon composition with excellent thermal stability. This composition is comprised of from about 5 to about 35 percent (by weight) of a condensation product derived from brominated phenol by the displacement of bromine from said phenol wherein: (a) said phenol is selected from the group consisting of tribromophenol, tetrabromophenol, pentabromophenol, and mixtures thereof; (b) said condensation product has a repeating structural unit of the formula ##STR1## WHEREIN A IS AN INTEGER OF FROM ABOUT 0 TO ABOUT 4, B IS AN INTEGER OF FROM ABOUT 0 TO ABOUT 2, C IS AN INTEGER OF FROM ABOUT 1 TO ABOUT 5, A PLUS B PLUS C EQUAL 5, Q is a monovalent bond from a carbon atom in the aromatic nucleus of said repeating structural unit to an oxygen atom bonded to an aromatic nucleus, and the polymeric units containing said repeating structural unit comprise at least 80 percent (by weight) of said product; (c) said condensation product contains from about 17 to about 31
Diindolylmethane is suggested to balance levels of estrogen, creating a healthy hormone balance for both men and women. Effects can relieve...
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Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzymeinhibitor, trandolaprilat. Trandolapril is chemically described as (2S, 3aR, 7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl] hexahydro-2-indo-linecarboxylic acid, 1-ethyl ester. Its empirical formula is C24H34N2O5and M.W.= 430.54
The α-aminoamide family of sodium ion channel blockers have exhibited analgesic effects on neuropathic pain. Here, a series of novel α-aminoamides containing an indole ring were designed and synthesized. These compounds were evaluated in mice using a formalin test and they exhibited significant anti-allodynia activities. However, the analgesic mechanism of these compounds remains unclear; a subset of the synthesized compounds can only moderately inhibit the sodium ion channel, Nav1.7, in a whole-cell patch clamp assay. Overall, these results suggest that introduction of an indole moiety to α-aminoamide derivatives can significantly improve their bioactivity and further study is warranted.
Genestra DIM- 60 capsules • Diindolylmethane (DIM) formulation • Provides 75 mg of 3,3-diindolylmethane per day • Convenient vegetable capsule format • Vegan formula • Dairy-free, gluten-free Each capsule of DIM provides 25 mg of 3,3-diindolylmethane. The recommended daily dosage is 3 capsules.
INDOLIN-6-AMINE | C8H10N2 | CID 34185 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
3-[(2-Fluorophenyl)(2-methyl-1H-indol-3-yl)methyl]-2-methyl-1H-indole | C25H21FN2 | CID 3612166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Alfa Aesar™ 5-Nitro-3-(1,2,3,6-tetrahydro-4-pyridyl)indole, 97% 1g Alfa Aesar™ 5-Nitro-3-(1,2,3,6-tetrahydro-4-pyridyl)indole, 97% Heterocyclic...
5-Methyl-4-nitro-2,1,3-benzoselenadiazole (1) was converted into 1,2,5-selenadiazolo[3,4-g]indole (3) by the Batcho-Leimgruber indole synthesis. Subsequent deselenation afforded 6,7-diaminoindole (4) which on treatment with biacetyl afforded 2,3-dimethylpyrrolo[2,3-f]quinoxaline (5) in 80% yield from 3.. ...
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2,3-dihydro-1H-indol-5-amine,dihydrochloride 2759-14-0 MSDS report, 2,3-dihydro-1H-indol-5-amine,dihydrochloride MSDS safety technical specifications search, 2,3-dihydro-1H-indol-5-amine,dihydrochloride safety information specifications ect.
Diindoylmethane is a molecule which is named after its structure, two indole groups attached to a methane group. It is commonly found in broccoli, and holds promise as being a molecule for anti-cancer effects and as an aromatase inhibitor.
55142-77-3 - PJYCVBMPEOJLKW-UHFFFAOYSA-N - Indole-3-carboxamide, N-(2-(hydroxy(3-indolyl)methylthio)ethyl)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Buy DIM Diindolymethane Capsules. DIM Diindolymethane aids healthy estrogen metabolism and helps balance hormones for men and women. We offer it for only...
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RISK ASSESSMENTS 11 5-(2-Aminopropyl)indole (5-IT) ISSN Report on the risk assessment of 5-(2-aminopropyl)indole in the framework of the Council Decision on new psychoactive substances About
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Kingchems team has developed reliable and robust processes to prepare indole analogs as key intermediates for our pharma customers.. ...
InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)/t17-/m0/ ...
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13712-78-2 - VOCVAFRQMGNEDM-UHFFFAOYSA-N - Indole, 3-((dimethylamino)methyl)-7-methyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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Learn more about 5-fluoro-1-methyl-2-oxo-2-3-dihydro-1h-indol-3-yl-acetic-acid. We enable science by offering product choice, services, process excellence and our people make it happen.
You are viewing an interactive 3D depiction of the molecule 3-(3-hydroxy-2-oxo-2,3-dihydro-1h-indol-3-yl)-l-alanine (C11H12N2O4) from the PQR.
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4-(1-benzenesulfonyl-6-fluoro-1H-indol-2-yl)-4-hydroxycyclohexa-2,5-dienone: has antineoplastic activity; structure in first source
You are viewing an interactive 3D depiction of the molecule n-methyl-l-leucyl-n-[2-(1h-indol-3-yl)ethyl]-nalpha-methyl-l-phenylalaninamide (C27H36N4O2) from the PQR.
Pure Encapsulations Indole-3-Carbinol 200 mg is a cruciferous phytonutrient that promotes prostate, breast and cervix health. Made in USA.
CARBINÓL, carbinoli, s.m. Denumire veche a alcoolului metilic. - Din fr. carbinol. Trimis de valeriu, 11.02.2003. Sursa: DEX 98  CARBINÓL s. v. alcool metilic, metanol. Trimis de siveco, 05.08.2004. Sursa: Sinonime  carbinól s. m., pl.…