The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
UNLABELLED The present study evaluated the role of SPECT/CT as an adjunct to (67)Ga (GS) or (111)In-labeled white blood cell (WBC) scintigraphy for diagnosis or localization of infection. METHODS Eighty-two patients (56 male and 26 female; mean age, 62 y) assessed for known or suspected infectious processes underwent 88 SPECT/CT studies. Forty-seven patients underwent GS SPECT/CT (13 with fever of unknown origin, 21 with suspected osteomyelitis, and 13 with suspected soft-tissue infection), and 35 patients underwent WBC SPECT/CT (24 with suspected vascular graft infection, and 11 with suspected osteomyelitis). Ninety-eight suggestive sites were identified (52 on GS and 46 on WBC). Additional information provided by SPECT/CT for diagnosis or localization of infection, as compared with planar and SPECT scintigraphy, was recorded. The SPECT/CT contribution was analyzed on a patient and site basis and was compared for the 2 tracers and clinical indications. RESULTS SPECT/CT provided additional
The investigators hypothesize that the new imaging method Gallium-68-DOTATATE has a higher diagnostic value in the detection of neuroendocrine tumors than the established imaging method Indium-111-Octreoscan. Therefore, the investigators will perform both imaging procedures in patients with suspected or confirmed neuroendocrine tumors. Subsequently, the investigators will compare the diagnostic performance of both methods ...
Purpose: It is often assumed that animal biodistributions of novel proteins are not dependent upon the radiolabel used in their determination. In units of percent injected dose per gram of tissue (%ID/g), organ uptake results (u) may be obtained using either iodine or metal as radioactive labels. Iodination is preferred as it is a one-step process whereas metal labeling requires two chemical procedures and therefore more protein material. It is important to test whether the radioactive tag leads to variation in the uptake value. Methods: Uptakes of 3antibodies to Carcinoembryonic Antigen (CEA) were evaluated in a nude mouse model bearing 150 to 300 mg LS174T human colon cancer xenografts. Antibodies included diabody (56 kDa), minibody (80kDa) and intact M5A (150 kDa) anti-CEA cognates. Both radioiodine and indium-111 labels were used with uptakes evaluated at 7 time(t) points out to 96 h. Ratios (R) of u(iodine-label)/u(indium-label) were determined for liver, spleen, kidneys, lung and tumor. ...
Abarelix clearance is increased when carefully taken along with Capromab pendetide. Diet, lifestyle advice columnist and poses difficult to find. Read More ...
Affibody molecules are a novel class of targeting proteins, demonstrating promising results in the molecular imaging of tumor markers. The aim of this study was to investigate the cellular processing of Affibody molecules bound to human epidermal growth-factor-receptor type 2 (HER2). Cellular processing of the synthetic Affibody molecule, DOTA-Z(HER2:342-pep2) (K(D) = 65 (p)M) labeled with indium-111, was studied both during continuous and interrupted incubation with HER2-expressing cell lines (SKOV-3, SKBR-3, and BT474). The internalized and membrane bound fractions of Affibody molecule were discriminated by treatment with 4 M of urea solution in 0.2 M of glycine buffer (pH 2.0). Incubation media collected after an interrupted incubation was analyzed for the presence of radiocatabolites. Continuous incubation of tumor cells with (111)In-DOTA-Z(HER2:342-pep2) led to the saturation of HER2 and slow internalization. Sixty (60)- to 80% of the radioactivity remained cell associated 24 hours after ...
Various techniques for detection of blood platelets in tissue section were evaluated in an incremental air embolism model of ischemia in order to further investigate the accumulation of platelets in brains subjected to cell-damaging ischemia. The experimental animals were dogs anesthetized with alpha-chloralose. A new autoradiographic technique was devised that allows precise localization of 111Indium-labeled platelets in brain sections. The technique is described in detail along with some effects of the label on platelet function and behavior. The technique can be performed in conjunction with 14C-iodoantipyrine autoradiographic measurement of blood flow without causing mutual interference or other forms of interaction. This permits the simultaneous investigation of local blood flow and deposition of platelets. ...
Indium In 111 ProstaScint (Capromab Pendetide) is indicated as a diagnostic imaging agent in newly-diagnosed patients with biopsy-proven prostate cancer, thought to be clinically-localized after standard diagnostic evaluation (eg chest x-ray, bone scan, CT scan, or MRI), who are at high-risk for pelvic lymph node metastases. It is not indicated for patients who are not at high risk.. Indium In 111 ProstaScint is also indicated as a diagnostic imaging agent in post-prostatectomy patients with a rising PSA and a negative or equivocal standard metastatic evaluation in whom there is a high clinical suspicion of occult metastatic disease. The imaging performance of Indium In 111 ProstaScint following radiation therapy has not been studied.. The information provided by Indium In 111 ProstaScint imaging should be considered in conjunction with other diagnostic information. Scans that are positive for metastatic disease should be confirmed histologically in patients who are otherwise candidates for ...
Most of the time you do not need special preparation. You will need to sign a consent form.. For the test, you will need to wear a hospital gown or loose clothing. You will need to take off all jewelry.. Tell your provider if you are pregnant. This procedure is NOT recommended if you are pregnant or trying to become pregnant. Women of childbearing age (before menopause) should use some form of birth control during the course of this procedure.. Tell your provider if you have or had any of the following medical conditions, procedures, or treatments, as they can interfere with test results:. ...
1. The rate of clearance from blood of 111In-labelled heat damaged autologous erythrocytes (HD-RBC) has been compared with that of simultaneously injected autologous 99mTc-labelled erythrocytes (IgG-RBC) coated with a Rhesus anti-D antibody. In 17 studies, the number of antibody molecules coating the erythrocytes was 9000 (high coating) and in nine studies the number was 5000 (low coating).. 2. On gamma camera imaging, IgG-RBC uptake, at both levels of coating, could be visualized only in the spleen. HD-RBC were predominantly taken up by the spleen, although slight 111In activity was visible in the liver.. 3. The blood clearance of IgG-RBC was mono-exponential, whereas that of HD-RBC was bi-exponential. The reciprocal of the t1/2 (the time taken for the 3 min value to fall by 50%) of the HD-RBC clearance correlated rather poorly with the rate constant of the simultaneous IgG-RBC clearance (r = 0.47, P , 0.05 at high coating; r = 0.75, P , 0.05 at low coating). The rate constant of the second ...
WebMD provides common contraindications for Kit For Indium-111-Ibritumomab Intravenous. Find out what health conditions may be a health risk when taken with Kit For Indium-111-Ibritumomab Intravenous
TY - JOUR. T1 - 99mTc-labeled divalent and tetravalent CC49 single-chain Fvs. T2 - Novel imaging agents for rapid in vivo localization of human colon carcinoma. AU - Goel, A.. AU - Baranowska-Kortylewicz, J.. AU - Hinrichs, S. H.. AU - Wisecarver, J.. AU - Pavlinkova, G.. AU - Augustine, S.. AU - Colcher, D.. AU - Booth, B. J.M.. AU - Batra, S. K.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Radioimmunopharmaceutical agents enabling rapid high-resolution imaging, high tumor-to-background ratios, and minimal immunogenicity are being sought for cancer diagnosis and imaging. Genetic engineering techniques have allowed the design of single-chain Fvs (scFvs) of monoclonal antibodies (mAbs) recognizing tumor-associated antigens. These scFvs show good tumor targeting and biodistribution properties in vivo, indicating their potential as imaging agents when labeled with a suitable radionuclide. Methods: Divalent (sc(Fv)2) and tetravalent ([sc(Fv)2]2) scFvs of mAb CC49 were evaluated for ...
Radionuclide molecular imaging has the potential to improve cancer treatment by selection of patients for targeted therapy. Affibody molecules are a class of small (7 kDa) high-affinity targeting proteins with appreciable potential as molecular imaging probes. The NOTA chelator forms stable complexes with a number of radionuclides suitable for SPECT or PET imaging. A maleimidoethylmonoamide NOTA (MMA-NOTA) has been prepared for site-specific labeling of Affibody molecules having a unique C-terminal cysteine. Coupling of the MMA-NOTA to the anti-HER2 Affibody molecule Z(HER2:239S) resulted in a conjugate with an affinity (dissociation constant) to HER2 of 72 pM. Labeling of [MMA-NOTA-Cys(61)]-Z(HER2:239S) with In-111 gave a yield of ,95% after 20 min at 60 degrees C. In vitro cell tests demonstrated specific binding of [In-111-MMA-NOTA-Cys(61)]-Z(HER2:239S) to HER2-expressing cell lines. In mice bearing prostate cancer DU-145 xenografts, the tumor uptake of [In-111-MMA-NOTA-Cys(61)]-Z(HER2:239S) ...
[105 Pages Report] Check for Discount on United States Indium Sales Market Report 2021 report by QYResearch Group. This report studies sales (consumption) of Indium in USA market,...
Our previous studies have indicated that the optimal dosage ratio of pretargeting antibody to effector is proportional to their maximum percent tumour accumulations (MPTAs). This study quantitatively describes how both MPTAs and their ratio change wi
Platelets labeled with indium-111 have been used successfully as a marker of active thrombosis in man. To establish the diagnostic accuracy of platelet scintigraphy in comparison to contrast venography in the diagnosis of acute lower limb venous thrombosis, we evaluated 103 consecutive patients divided into two groups. Platelets were labeled by the indium-111 oxine method. Patients from group I (n = 73, 56 had venograms) were asymptomatic and underwent platelet scintigraphy 1.1 +/- 0.6 days (mean +/- 1 SD) after a major orthopedic procedure. Patients from group II (n = 30, all had venograms) were symptomatic and underwent platelet scintigraphy 1.2 +/- 1.7 days after venography. In group II, 15 patients with positive findings on contrast venography were treated with intravenous heparin; five others with positive venograms did not receive heparin until platelet scintigraphy was completed. Both platelet scintigraphy and contrast venography were evaluated by two blinded observers. Only studies with ...
We performed radionuclide scanning after the intravenous injection of human IgG labeled with indium-111 in 128 patients with suspected focal sites of inflammation. Localization of 111In-labeled IgG correlated with clinical findings in 51 infected patients (21 with abdominal or pelvic infections, 11 with intravascular infections, 7 with pulmonary infections, and 12 with skeletal infections). Infecting organisms included gram-positive bacteria, gram-negative bacteria, Pneumocystis carinii, Mycoplasma pneumoniae, and Candida albicans. No focal localization of 111In-labeled IgG was observed in 63 patients without infection. There were five false negative results, and nine results were unusable. Serial scans were carried out in eight patients: continued localization correctly predicted relapse in six, and the absence of localization indicated resolution in two. To determine whether 111In-labeled IgG localization was specific for inflammation, we studied 16 patients with cancer. Focal localization ...
Looking for focal infection? Find out information about focal infection. Infection in a limited area, such as the tonsils, teeth, sinuses, or prostate Explanation of focal infection
The Agg+ strain of S. sanguis induces platelet aggregation or clotting in vivo as predicted by the in vitro data. Aggregation in vitro is all-or-none with a dose-dependent delay (23). In vitro, rabbit platelets aggregate in response to the Agg+ strain in about two minutes. The experiments in vivo had been designed to record hemodynamic and cardiopulmonary responses upon a 1-min infusion of S. sanguis. Direct evidence for platelet aggregation or clotting in vivo include thrombocytopenia and, when compared to the Agg− strain, accumulation of 111Indium-labeled platelets in the lungs (Fig. 5), but not in the spleen. Platelets normally clear from the circulation to the spleen, but the 111Indium-labeled platelets used as tracers do not. The frequency and extent of manifestations of platelet clotting in vivo increase directly with the dose of inoculated Agg+S. sanguis.. Changes in heart rate and blood pressure occur more rapidly than would be predicted by the two minute lag time for in vitro platelet ...
An object hereof is to provide a method of making, a gap, which can provide good electron-emitting properties, simply, with low electric power and in short time. A method of fabricating an electron-emitting device, including a process of flowing a current in electroconductive film containing first particles and second particles including resistance lower than resistance of the first particle and thereby forming a gap in a portion of the above described electroconductive film, wherein the ratio of the above described first particle contained in the above described film is not less than 2% and not more than 30% and the ratio of resistance of the above described first particle to resistance of the above described second particle is not less than 5 and not more than 1000.
We have examined the possible mechanisms of resistance to the epidermal growth factor receptor (EGFR) inhibitors in tumor cells with variable levels of EGFR. ZD1839 (Iressa) is a small-molecular-weight, ATP-mimetic that specifically inhibits the EGFR tyrosine kinase. A431 cell growth was markedly in …
INDIUM: If you look for indium on the periodic chart, you will see that it located right by tin (Sn) and lead (Pb) but it is a world away in terms of its properties. Indium...
indium target manufacturers indium target suppliers Directory - Browse indium target products,Choose Quality indium target manufacturers, suppliers, factory at B2BAGE
Optical limiting properties in CH2Cl2 solution of a series of axially substituted InTPP (indium tetraphenyl-porphyrin) and axially substituted InTTP (indium tetra-p-tolyl-porphyrin) are investigated using a 532 nm laser with a pulse duration of 5 ns. The axial substitutions include -Cl, -SCN, -SPh and -SPh(p-Me). The optical limiting measurements reveal that the optical limiting properties of the indium porphyrins are greatly influenced by the axially attached functional groups. A limiting threshold of 0.18 J/cm2 is achieved for TTPInSCN, which is the best optical limiting material in this report. Z-scan experiments are also conducted and confirm that the good optical limiting performance of these indium porphyrins is due to the large value of σex/σg ...
1. The intrasplenic kinetics of granulocytes, isolated in plasma and labelled in plasma with 111In-tropolonate, have been studied in normal subjects, patients with negative studies for inflammatory disease and patients with positive studies, with the aim of identifying the nature of splenic activity seen after 111In-labelled granulocyte administration.. 2. Up to 40 min after injection, 111In activity was visible only in major blood vessels, liver and spleen, with slight, abnormal activity visible in most of those with positive scans. The time courses of uptake of hepatic and splenic activity were different, with liver activity rapidly reaching a plateau and splenic activity increasing mono-exponentially to a plateau achieved between 20 and 40 min.. 3. The clear difference between the shapes of the hepatic and splenic uptake curves and the magnitude of the splenic uptake rate constant indicated that splenic activity represented reversible uptake.. 4. The application of deconvolution analysis to ...
The MoAb E4 is a promising radiotracer for prostate cancer and may be used in radioimmunotherapy. As in earlier studies, TS1 shows significant radioimmunolocalization into necrotic tumor tissue, which also exists in prostate cancer.. ...
TY - JOUR. T1 - Synthesis, crystal and molecular structure of the first indium trihydride complex, [InH3{CN(Pri)C2Me2N(Pr i)}]. AU - Hibbs, David E.. AU - Hursthouse, Michael B.. AU - Jones, Cameron. AU - Smithies, Neil A.. PY - 1998/4/21. Y1 - 1998/4/21. N2 - The reaction of either [InH3(NMe3)] or LiInH4 with an excess of the imidazol-2-ylidene carbene, :CN(Pri)C2Me2N-(Pri), affords the first example of an indium trihydride complex, [InH3{CN(PriMe2N(Pri)}], the X-ray crystal structure of which is described.. AB - The reaction of either [InH3(NMe3)] or LiInH4 with an excess of the imidazol-2-ylidene carbene, :CN(Pri)C2Me2N-(Pri), affords the first example of an indium trihydride complex, [InH3{CN(PriMe2N(Pri)}], the X-ray crystal structure of which is described.. UR - http://www.scopus.com/inward/record.url?scp=0002911950&partnerID=8YFLogxK. U2 - 10.1039/a801118d. DO - 10.1039/a801118d. M3 - Article. AN - SCOPUS:0002911950. SP - 869. EP - 870. JO - Chemical Communications. JF - Chemical ...
A novel affinity system for a two-phase delivery of radionuclides to tumor cells has been developed. In the first phase, a nontoxic bivalent monoclonal antibody conjugated to an enzyme is targeted to the tumor cells. In the second phase, a radionuclide-derivatized enzyme inhibitor, specific for the enzyme conjugated to the antibody, is administered. The model system selected for this study is the recombinant human enzyme dihydrofolate reductase (rhDHFR) and its high-affinity competitive inhibitor methotrexate (MTX). MTX was labeled with a radionuclide by covalent attachment of diethylenetriaminepentaacetic acid (DTPA) complexed with 111In. Using the γ-carboxyl residue of MTX for the attachment of DTPA, binding of the inhibitor to rhDHFR was not affected. The inhibitory activities of nonderivatized MTX and DTPA-MTX were indistinguishable. Human K562 erythroleukemia cells were used to evaluate under in vitro conditions the DHFR-MTX affinity system for the delivery of 111In-labeled DTPA-MTX to ...
Anti-EGFR Affibody® Molecule Affibody® Molecule datasheet (ab95116). Abcam offers quality products including antibodies, assays and other reagents.
A 36-year-old, Hispanic man died at a pork processing plant in central Iowa mid-winter of 2004. The victim had his feet entangled in an inclined, auger conveyor when it started. He was retrieving hardware or pieces of metal that had fallen into the auger during dismantling of conveying equipment and metal decking above the auger earlier that day and the day before. In an adjacent room the supervis
Page contains details about indium sulfide film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Materion Advanced Chemicals Indium oxide; Purity: 99.999, CAS 1312-43-2, Materion Item Number SS-236. Call 419-289-9800 to order.
Indium products cover the whole range of soldering products and soldering materials made from the highest-quality metals, materials, and alloys.
Our client, a 21-year-old farmer, was working on his 1969 Ford New Holland combine when an accident cost him his leg. He was using the machine to harvest and thresh wheat. In this type of combine, after the wheat is collected, the machine separates the heads from the straw and deposits the heads in a holding tank. The separation is facilitated by two rotating augers, a leveling auger and a discharge auger. They help to move the grain through the machine. At the time of the accident, the discharge auger was clogged, and our client was trying to reach a stick to fix it. As he leaned forward, however, his shirt was caught on the bolt of the leveling auger, and he was pulled down into the tank. His foot slipped beneath the discharge augers shield and was severely injured. He had to have his leg amputated below the knee. We argued that the combines protruding bolt was defective, the shields insufficient, and the manufacturers manual deficient in explaining how to safely fix discharge auger clogs. ...
AnazaoHealth®, Anazao®, Create, Heal, Live.®, the Compass, and Zāo® are registered trademarks of AnazaoHealth Corporation.. ...
Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides
Neuroendokrine gastroenteropankreatische (NE-GEP) Tumore exprimieren Somato-statin-Rezeptoren mit hoher Dichte und Affinität [1]. Diese Rezeptoren können in vivo mittels eines Indium-111-markierten...
TY - JOUR. T1 - Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies directed against intracellular antigens. AU - Haisma, Hidde J.. AU - Pinedo, H. M.. AU - Silva, Carlos A.. AU - Boven, Epie. PY - 1992/9/18. Y1 - 1992/9/18. N2 - For investigations involving monoclonal antibodies (mAbs) against cellular antigens cell binding assays are routinely used to determine the immunoreactive fraction after radiolabeling. In general, surface antigens are targets for radioimmunodetection, but recent studies indicate that intracellular determinants may also prove useful for this purpose. Thus, there is a need to adapt the regular cell binding assay for use with antibodies directed against cytoplasmic antigens. Here we describ a fixation method which permits such mAbs to bind to cell surfaces as well as to intracellular determinants. Moreover, the procedure may be used for antigens that are sensitive to the commonly used aldehyde fixatives. The method is illustrated with two ...
Mounting evidence shows that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. 120 h p.i. In vivo uPA specificity of 89Zr-Df-ATN-291 was confirmed by successful pharmacological blocking of tumor uptake with ATN-291 in U87MG tumors. Akap7 Although the detailed mechanisms behind [19], and more recently, an 111In-labeled antibody adopted for prostate cancer imaging with remarkable tumor accumulation [20]. Our goal was to investigate a novel probe for effective targeting and imaging of the uPA/uPAR system in cancer with excellent targeting specificity and image contrast. To achieve this goal, 89Zr-labeled Bortezomib ATN-291 (i.e., 89Zr-Df-ATN-291; Df is abbreviated for deferoxamine) was used as an immunoPET probe. 89Zr (t1/2 = 78.4 h) was selected as the radiolabel in this study to provide a longitudinal evaluation on the interaction between ATN-291 and different tumor types [21]. To accomplish this goal, various studies were carried out to ...
Mounting evidence shows that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. 120 h p.i. In vivo uPA specificity of 89Zr-Df-ATN-291 was confirmed by successful pharmacological blocking of tumor uptake with ATN-291 in U87MG tumors. Akap7 Although the detailed mechanisms behind [19], and more recently, an 111In-labeled antibody adopted for prostate cancer imaging with remarkable tumor accumulation [20]. Our goal was to investigate a novel probe for effective targeting and imaging of the uPA/uPAR system in cancer with excellent targeting specificity and image contrast. To achieve this goal, 89Zr-labeled Bortezomib ATN-291 (i.e., 89Zr-Df-ATN-291; Df is abbreviated for deferoxamine) was used as an immunoPET probe. 89Zr (t1/2 = 78.4 h) was selected as the radiolabel in this study to provide a longitudinal evaluation on the interaction between ATN-291 and different tumor types [21]. To accomplish this goal, various studies were carried out to ...
207398-97-8,Indium(III) nitrate hydrate, 99.999% trace metals basis,Indium(III) nitrate hydrate,Indium(III) nitrate hydrate, 99.99% trace metals basis,MFCD00149742
Indium, 99.99% (trace metal basis), foil, 0.127mm thick, ACROS Organics™ 2.3g Indium, 99.99% (trace metal basis), foil, 0.127mm thick, ACROS Organics™ Indium
A method has been developed to characterize large populations of individual respirable particles. With the use of custom data collection and data correlation computer software, the same set of particles can be analyzed in multiple instruments. The method is demonstrated by the analysis of a sample of hard-metal particles. A series of particles are analyzed by Auger electron spectroscopy, and then
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
... Information for Physicians. Diagnostic imaging for prostate cancer with In-111 ProstaScint® is easier with AnazaoHealth.. AnazaoHealth provides In-111 radiolabeled ProstaScint as a unit dose vial compounded for your patient.. Imaging with In-111 ProstaScint® serves as a noninvasive test to evaluate soft tissue outside the prostate area for metastatic disease. In-111 ProstaScint® provides information that complements PSA, Gleason score and clinical stage.. Scans using In-111 ProstaScint® provide information that can help identify which course of treatment is most appropriate for your patient. It can also help detect lesions not visible by CT or MRI scans.. Having the ability to see what is needed to heal your patient is imperative. In-111 ProstaScint® is clearly the better choice.. ProstaScint® is a registered trademark of EUSA Pharma (JSA), Inc.. Please contact AnazaoHealth for information about these products.. ...
As announced in the Indium press release on Nov. 24th the Indium Corporation of America has introduced 1075-EXR 46 wave solder flux specifically designed to meet the process demands of Pb-Free manufacturing.
Research proven ADAM15 Rabbit Polyclonal IgG Antibody. Immunohistochemistry, Western Blot, Immunocytochemistry, and Immunofluorescence applications. Human, mouse, and rat specificity
Anti-Insulin Affibody® Molecule Affibody® Molecule datasheet (ab31906). Abcam offers quality products including antibodies, assays and other reagents.
Autori: A.P. Rambu, D. Sirbu, M. Dobromir, G. G. Rusu. Editorial: Solid State Sciences, 14(10) , p.1543, 2012.. Rezumat:. Cuvinte cheie: Indium oxide, Structural characteristics, Electronic transport mechanism. ...
Each PerkinElmer Indium (In) Pure Grade Atomic Spectroscopy Calibration Standard is supplied with a comprehensive Certificate of Analysis.