indene definition: a colorless, oily hydrocarbon, CH, obtained from coal tar and used in the manufacture of synthetic resinsOrigin of indene ind(ole) + -ene...
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Ferrocenoindenes display planar chirality and thus represent valuable ligands for asymmetric catalysis. Here, we report on the synthesis of novel 3-(1,1-dibromomethylene)ferroceno[1,2-a]indene, (Z)-3-(1-bromomethylene)-6-iodoferroceno[1,2-a]indene, and benzo[5,6-f]ferroceno[2,3,a]inden-1-one. Any application-oriented design of chiral catalysts requires fundamental knowledge about the ligands involved, not only in terms of atom-connectivity, but also in terms of their three-dimensional structure and steric demand. Therefore, the crystal structures of 2-ferrocenylbenzoic acid, ferroceno[1,2-a]indene, and (Z)-3-(1-bromomethylene)-6-iodoferroceno[1,2-a]indene have been determined. The bond-lengths that can be retrieved therefrom also allow for an estimation of the reactivity of the aryl-iodo, bromo-methylidene and dibromomethylidene moieties.
Semantic Scholar extracted view of Selective Construction of Spiro[indene‐2,4′‐pyrido[1,2‐ a ]quinolines] and Dihydroindeno[1,2‐ b ]pyrene via Domino Reactions of Huisgens 1,4‐Dipoles by Yuan-yuan Zhang et al.
SUMMARY: Coronatine-producing and non-producing strains of Pseudomonas syringae pv. glycinea have been examined. We found a connection between copper resistance and synthesis of coronatine. Published data implied that these properties may be encoded on different plasmids. Production of coronatine and copper resistance were also found to be correlated for pv. glycinea in 19 field-isolates from leaf spots of plants in a soybean field and in 28 strains of a bacterial culture collection. Genomic diversity within pv. glycinea was investigated by plasmid profiling, DNA hybridization studies and PCR analysis. All strains unable to produce coronatine (cor-) were sensitive to copper ions and showed no homology to DNA from plasmid pSAY1, which carries a gene cluster for steps in coronatine production. In addition, cor- strains could be distinguished from coronatine-producing strains by a single unique band when amplified by random primer PCR. Plasmid profiles of strains isolated from field-populations during 1983
(1S,3aS,3bS,5aR,9aR,9bS)-N-tert-butyl-9a-methyl-7-oxo-2,3,3a,3b,4,5,5a,6,9b,10,11,11a-dodecahydro-1H-indeno[5,4-f]quinoline-1-carboxamide 166896-74-8 NMR spectrum, (1S,3aS,3bS,5aR,9aR,9bS)-N-tert-butyl-9a-methyl-7-oxo-2,3,3a,3b,4,5,5a,6,9b,10,11,11a-dodecahydro-1H-indeno[5,4-f]quinoline-1-carboxamide H-NMR spectral analysis, (1S,3aS,3bS,5aR,9aR,9bS)-N-tert-butyl-9a-methyl-7-oxo-2,3,3a,3b,4,5,5a,6,9b,10,11,11a-dodecahydro-1H-indeno[5,4-f]quinoline-1-carboxamide C-NMR spectral analysis ect.
Sprawdź ile zapłacisz za lek carbenicillin indanyl w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
1-amino-2-ethylcyclopropane-1-carboxylic acid: an ethylcyclopropyl amino-acid derived from isoleucine; it may be coupled to coronafacic acid by coronafacate ligase to form coronatine; substrate of malonyltransferase & inhibitor of 1-aminocyclopropane-1-carboxylic acid malonyltransferase; RN given refers to cpd without isomeric designation
Potential coronamic acid exporter of 236 aas and 5 TMSs. Coronamic acid (CMA), an ethylcyclopropyl amino acid derived from isoleucine, functions as an intermediate in the biosynthesis of coronatine, a chlorosis-inducing phytotoxin produced by Pseudomonas syringae pv. glycinea PG4180. The DNA required for CMA biosynthesisincludes three distinct open reading frames (ORFs) which share a common orientation for transcription. Two ORFs in the operon include CmaT, a thioesterase and CmaU, a potential exporter (Ullrich and Bender 1994). ...
2,3,4,5-TETRAHYDRO-1,5-METHANO-2-OXO-1H-3-BENZAZEPINE A solution of 3-cyano-1 H-indene-1-carboxylic acid methyl ester (6.40 g, 32.2 mmol) in MeOH (30 mL) in a pressure reactor was purged with nitrogen for 5 minutes and charged with 5% palladium on carbon (6.84 g, 1.61 mmol) and concentrated sulfuric acid (3.57 mL, 64.3 mmol). The pressure reactor was purged with nitrogen and evacuated three times, then purged with hydrogen and evacuated three times before charging the bomb with hydrogen to a pressure of 50 psi (3.4 atmospheres) and mechanically shaking. After 5 minutes the hydrogen pressure decreased to 15 psi (approximately 1 atmosphere), and the reaction vessel was charged with hydrogen to increase pressure to 50 psi (3.4 atmospheres). After 16 hours the reactor was evacuated and purged with nitrogen three times before filtering the reaction mixture through a nylon disk. Methanol was displaced by isopropanol and stripped to dryness three times with isopropanol to remove water. The concentrated ...
Rhodococcus sp. 124 is a Gram-positive soil bacterium being developed for the manufacture of (-)cis-(1S,2R)-1-aminoindan-2-ol, a key precursor in the production of the HIV-1 protease inhibitor CrixivanTM, from the aromatic hydrocarbon indene. Rhodococcus sp. 124 was grown by batch fermentation in the presence of naphthalene and indene to measure changes in gene expression and aromatic hydrocarbon metabolism with DNA microarray technology. Genes were selected for microarray analysis based on functional annotation assignments made by the Consensus Annotation by Phylogeny Anchored Sequence Alignment (CAPASA) program, a high throughput system for automated functional annotation assignment of DNA sequence similarity search results. CAPASA was validated by comparison to several methods of annotation, and the agreement to other methods ranged from 75-94%. Microarray results were analyzed by the newly described method of trigonometric deconvolution, a mathematical system for the measurement of changes ...
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104813-25-4 - QXSHFYIDEWCTHQ-UHFFFAOYSA-N - 11H-Indeno(1,2-b)quinolin-11-one, 10-amino-, monohydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
4-methoxy-6-methyl-7H-indeno[2,1-c]quinolin-7-one - chemical structural formula, chemical names, chemical properties, synthesis references
53762-06-4 - MJHUETMMRFZKID-UHFFFAOYSA-N - 1H-Indeno(2,1-c)pyridine, 2,3,4,4a,9,9a-hexahydro-2,9,9-trimethyl-, hydrochloride, trans-(+-)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
This is an 8-week randomized, double blind, placebo-controlled pilot study with 4- week follow up assessment, of ramelteon 8 mg/day, administered to subjects for 8 consecutive weeks as an adjunctive therapy in 40 non-diabetic schizophrenia subjects to examine ramelteon effects on body composition, glucose and lipid metabolism, sleep quality and symptoms of tardive dyskinesia using the Massachusetts General Hospital General Clinical Research Center. As far as we know, no previous study has been done to explore the potential role of ramelteon in improving metabolic, sleep, and movement disturbances in schizophrenia subjects. The novel approach of adjunctive ramelteon treatment in the schizophrenia population is promising ...
This is an 8-week randomized, double blind, placebo-controlled pilot study with 4- week follow up assessment, of ramelteon 8 mg/day, administered to subjects for 8 consecutive weeks as an adjunctive therapy in 40 non-diabetic schizophrenia subjects to examine ramelteon effects on body composition, glucose and lipid metabolism, sleep quality and symptoms of tardive dyskinesia using the Massachusetts General Hospital General Clinical Research Center. As far as we know, no previous study has been done to explore the potential role of ramelteon in improving metabolic, sleep, and movement disturbances in schizophrenia subjects. The novel approach of adjunctive ramelteon treatment in the schizophrenia population is promising ...
Find out about the science and chemistry of Ramelteon (Rozerem), see colourful images of Ramelteon and explore interactive 3D molecules of Ramelteon
A series of indanyl derivatives of diethylstilbestrol (DES) have recently been identified as inv vivo metabolites of DES. These compounds are of interest because they possess effective uterine estrogen receptor-binding affinity but poor biological activity. The X-ray crystal structures of three of these derivatives were determined and their conformations were compared with those of estradiol and DES. The more active derivatives, indenestrol A (I) and indenestrol B (II) have nearly identical conformations, in which the overall molecule is highly planar, the phenyl ring is twisted out of the plane of the indene rings by approximately 30 degrees, and the distance between the hydroxyl groups is 11.6 A. In the least active derivative, idanestrol (III), the methyl, ethyl, and phenyl substituents were found to be in the same side of the indane ring so that the molecule is constrained to an L-shape. The crystallographically observed conformations of I, II, III, DES, and estradiol, their competative ...
N-bromosuccinimide or dibromodimethylhydantoin on (2) [4] and subsequent treatment with pyridine (yield c a . 1 5 04). Accordingly, the so-called pentatetraene has the constitution (3) of tetra-(P,P-diphenylvinyl)ethylene, in agreement with its N M R spectrum, molecular-weight measurements, and other results. (1) (CaH5)2C=C=C=C=C(C6H5)2 (2) (CsH5)2C==CH CH ~CH-C(CaH5)z ~ (C6Hc),C=CH-LH~--CH=C(CsHc)2 (3) (CaHc)2C-CH--C (CsH,);C-CH CHy-C(CsH5)z II -C CH -C(CaH& So far, all attempts to prepare genuine pentatetraenes have resulted in ring-closure to yield derivatives of indene [ I ] or dimerisation with or without partial hydrogenation. Received, April 29tI1, 1963 [Z 492/325 IE] German version: Ang-w. Chem. 75,452 (1963). [I] Communication No. X V on Cumulenes; Communication No. X I V : R . Kuhn and B. Schulz, Angew. Chem. 74,292 (1962); Angew. Chem. internat. Edit. I , 211 (1962). [2] F. Rohlmann and K . Kieslich, Abh. braunschweig. wiss. Ges. I 9 5 7 , I X . 147. [3] G. Mavin, Thkse Ingenieur ...
Alcohol and medicines such as rifampin or fluconazole may cause drug interactions with ramelteon. This eMedTV article describes the problems that may arise from combining medications and lists other drugs that may cause ramelteon interactions.
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide - chemical structural formula, chemical names, chemical properties, synthesis references
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis ...
This trial investigated the efficacy of ramelteon [Takeda] for the treatment of insomnia and mood instability, in patients with bipolar I disorder. The primary
ROZEREM (ramelteon) is approved for adults having trouble falling asleep from insomnia. Ask your doctor about ROZEREM. See Important Safety Information and Prescribing Information.
Learn about Rozerem (Ramelteon) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Product information about ROZEREM (ramelteon), including mechanism of action, clinical data, and patient profile. See Important Safety Information and Prescribing Information.
... , But can also throw scale weight off. In all three games, Ash is voiced by Bruce Campbell.
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Three randomized, double-blind trials in subjects with chronic insomnia employing polysomnography (PSG) were provided as objective support of ramelteons effectiveness in sleep initiation. One study enrolled younger adults (aged 18 to 64 years, inclusive) with chronic insomnia and employed a parallel design in which the subjects received a single, nightly dose of ramelteon (8 mg or 16 mg) or matching placebo for 35 days. PSG was performed on the first two nights in each of Weeks 1, 3, and 5 of treatment. Ramelteon reduced the average latency to persistent sleep at each of the time points when compared to placebo. The 16 mg dose conferred no additional benefit for sleep initiation. The second study employing PSG was a three-period crossover trial performed in subjects aged 65 years and older with a history of chronic insomnia. Subjects received ramelteon (4 mg or 8 mg) or placebo and underwent PSG assessment in a sleep laboratory for two consecutive nights in each of the three study periods. Both ...
Three randomized, double-blind trials in subjects with chronic insomnia employing polysomnography (PSG) were provided as objective support of ramelteons effectiveness in sleep initiation. One study enrolled younger adults (aged 18 to 64 years, inclusive) with chronic insomnia and employed a parallel design in which the subjects received a single, nightly dose of ramelteon (8 mg or 16 mg) or matching placebo for 35 days. PSG was performed on the first two nights in each of Weeks 1, 3, and 5 of treatment. Ramelteon reduced the average latency to persistent sleep at each of the time points when compared to placebo. The 16 mg dose conferred no additional benefit for sleep initiation. The second study employing PSG was a three-period crossover trial performed in subjects aged 65 years and older with a history of chronic insomnia. Subjects received ramelteon (4 mg or 8 mg) or placebo and underwent PSG assessment in a sleep laboratory for two consecutive nights in each of the three study periods. Both ...
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.
Pseudomonas syringae CmaA protein: involved in coronamic acid biosynthesis in Pseudomonas syringae; amino acid sequence given in first source; GenBank U14657
Ramelteon is a melatonin receptor agonist. According to the manufacturer, its molecular structure is composed of a substituted tetrahydroindenofuran derivative
গুণ Pharmaceutical Intermediates নির্মাতারা & রপ্তানিকারক - কেনা Rozerem (Ramelteon) for Insomnia Treatment Pharmaceutical Intermediates Powder CAS 196597-26-9 চীন থেকে উত্পাদক.
Clincally available camptothecin derivatives, though highly effective against a broad range tumors, are limited by their chemical instability, solubility, ABCG2-mediated efflux and reversibility of Top1-DNA complexes. Indenoisoquinolines were identified as topoisomerase I (Top1) inhibitors by the COMPARE analysis of the NCI drug screen database. Although structurally similar to camptothecin, idenoisoquinolines are chemically stable, able to overcome ABCG2 efflux while forming more persistent Top1-DNA complexes and maintaining potent antitumor activity. The potential for indenoisoquinoline derivatives as possible clinical agents is further aided by the synergistic effect observed between camptothecin and Chk1/2 inhibitors. Chk1/2 kinases regulate cell cycle, DNA damage response via ATM, ATR and DNA-PK, which are activated by genomic instability. Previous studies have shown Chk1/2 inhibitors, such as UCN-01, can potentiate camptothecin-mediated cytotoxicity in p53 mutant cells by eliminating the ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The IUPHAR/BPS Guide to Pharmacology. DIOA ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Compounds having the formula: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, ...
Phosphorus › (11bS)-N-((R)-2,3-dihydro-1H-inden-1-yl)-N-(di-n-butylmethyl)dinaphtho[2,1-d:1,2-f][1,3,2]dioxaphosphepin-4-amine ...
Grundmanns Ketone,(1R,3aR,7aR)-1-[(1R)-1,5-Dimethylhexyl]octahydro-7a-methyl-4H-inden-4-one,(1R,3aR,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydroinden-4-one,Windaus-Grundmann ketone
A short, efficient and highly stereoselective synthesis has been developed for a series of 6‐indanyl‐3‐alkyl‐7‐aryl/heterocyclic‐(3R, 6R, 7R)‐2 ...
Sivujen prealphabetaversio on valmis. Lisään tähän ominaisuuksia sitä mukaan ku kerkeän niitä tekemään tai tarvetta on. Ainakin pelaajaprofiileja, jonkin sortin tiedotusjärjestelmää ja graafiikkaa on jossain vaiheessa tulossa. Tarkoitus olisi loppujen lopuks vääntää nämä sivut englanniksi ...
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR ...
There are 1799 words beginning with PH: PHACELIA PHACELIAS PHACOID ... PHYTOTOXINS PHYTOTRON PHYTOTRONS. Every word on this site can be used while playing scrabble. Create other lists, that end with or contain letters of your choice.
李位仁(2010/08/01-2012/07/31)。重點一子題2---含嘧啶或亞碳配子或C4對稱氧釩中心四聚體之鎳和銅錯合物進行不對稱共軛加成及碳氫化合物氧合化反應之研究。國科會。(NSC 98-2119-M-003-002-MY3 )。主持人 ...
0031] In the process of the present invention, the compound represented by the above formula (1) is reacted in the presence of the above binuclear metal complex. This reaction is preferably carried out in a liquid state. When the starting material compound is liquid, the compound represented by the above formula (1) may be mixed with the binuclear metal complex in the absence of a solvent but the above reaction is preferably carried out in the presence of a suitable solvent. The solvent which can be used herein is not particularly limited as long as it dissolves the compound represented by the above formula (1) and does not react with the compound and the above binuclear metal complex. Examples of the solvent include hydrocarbon solvents such as n-pentane, n-hexane, n-heptane, n-octane, n-decane, dicyclopentane, benzene, toluene, xylene, durene, indene, tetrahydronaphthalene, decahydronaphthalene and squalane; ether solvents such as dipropyl ether, ethylene glycol dimethyl ether, ethylene glycol ...