Welcome to the Oxford Clinical Psychology subscriber services. These pages contain information on accessing Oxford Clinical Psychology, managing your purchases or subscriptions, and getting help if you have a problem.. Oxford Clinical Psychology is available via subscription and perpetual access. Pick which select titles you would like using our title-by-title sales model, or subscribe to or purchase the entire resource.. For institutions. Oxford Clinical Psychology is available to libraries, institutions, and group and private practices worldwide.. Find out how you can purchase or subscribe.. For individuals. If you are a student or academic, you can recommend Oxford Clinical Psychology to your librarian.. If you are a professional at a group or private practice, find out how you can purchase or subscribe.. ...
Generations of readers have learned social psychology from this book-it provides balanced, up-to-date, and accurate coverage of basic topics, research, and theories. Balancing cutting-edge findings and classic work in the field, the user-friendly Social Psychology shows how its methods and theories can be applied to everyday experiences and current social issues. Interesting and easy to read and understand, the topics covered are broad in scope but not overwhelming; these include: perception of people and events; attitudes and influence; social interactions and relationships; helping and hurting others; social psychology and health; and social psychology and the law. Teachers, health professionals, lawyers, business leaders, and people in many different professions will find Social Psychology to be a valuable reference and handbook.
The Beckwith-Wiedemann syndrome, originally described by Beckwith in 1963 and Wiedemann in 1964, included congenital anomalies such as macroglossia, exomphalos, postnatal somatic gigantism, severe hypoglycemia, abdominal wall defect, capillary nevus flameus and hemihypertrophy. Macroglossia is the most common manifestation of Beckwith-Wiedemann syndrome, with studies reporting between 82 and 95 percent of the cases. Macroglossia may cause the upper airway obstruction, deglutition difficulty, articulation interference and protrusion of dentoalveloar structures resulting in anterior open bite and a mandibular prognathism. We experienced a 5 month-old male with upper airway obstruction, deglutition difficulty and recurrent upper airway infection due to macroglossia associated with Beckwith-Wiedemann syndrome and significant improvement in respiration, feeding and oral competence at 14 months follow-up after rhomboid resection and primary closure of tongue. ...
Hi, Welcome to this Club where families and friends of those who have Angelman Syndrome can share and give each other support on raising a child with Angelman Syndrome. We have a 2 & 1/2 yr. old son with Angelman Syndrome caused by a chromosone 15 deletion. For more information about Angelman Syndrome, you may go to the ASF home page at: http://www.angelman.org
TY - JOUR. T1 - Molecular diagnosis of Beckwith-Wiedemann Syndrome using quantitative methylation-sensitive polymerase chain reaction. AU - Coffee, Bradford. AU - Muralidharan, Kasinathan. AU - Highsmith, William E.. AU - Lapunzina, Pablo. AU - Warren, Stephen T.. PY - 2006/10/1. Y1 - 2006/10/1. N2 - PURPOSE: Beckwith-Wiedemann Syndrome is caused by defects in imprinted gene expression at 11p15. Currently, quantitative Southern analysis using DNA methylation-sensitive restriction enzymes is used in molecular diagnosis of this syndrome. METHODS: We describe a rapid and highly quantitative test for assessing DNA methylation at 11p15 using sodium bisulfite treatment of genomic DNA coupled with quantitative TaqMan methylation-sensitive polymerase chain reaction. RESULTS: TaqMan MSP can assess DNA methylation at both differentially methylated region (DMR)1 and DMR2 at 11p15. In addition, by using TaqMan MSP we were able to determine the parent of origin of a duplication of 11p15 by quantification of ...
The CPIP uniquely integrates complementary training experiences at the Psychiatry Departments Vermont Center for Children, Youth, and Families (VCCYF) and the Psychology Departments Behavior Therapy and Psychotherapy Center (BTPC). At the VCCYF, interns receive advanced training in the application of evidence-based interventions from the family perspective, directly addressing both child and parent emotional and behavioral strengths and difficulties. In the framework of the Vermont Family Based Approach, interns apply health promotion, prevention, and intervention to help the well families remain well, prevent at-risk children from developing emotional and behavioral problems, and intervene comprehensively with children and families challenged by psychopathology. At the VCCYF, interns collaborate with professionals in psychiatry, psychology, social work, nursing, and genetics. At the BTPC, interns receive advanced training in culturally competent, evidence-based treatment of torture survivors ...
TY - JOUR. T1 - The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. AU - Ranzani, Valeria. AU - Rossetti, Grazisa. AU - Panzeri, Ilaria. AU - Arrigoni, Alberto. AU - Bonnal, Raoul J P. AU - Curti, Serena. AU - Gruarin, Paola. AU - Provasi, Elena. AU - Sugliano, Elisa. AU - Marconi, Maurizio. AU - De Francesco, Raffaele. AU - Geginat, Jens. AU - Bodega, Beatrice. AU - Abrignani, Sergio. AU - Pagani, Massimiliano. PY - 2015/2/17. Y1 - 2015/2/17. N2 - Long noncoding RNAs are emerging as important regulators of cellular functions, but little is known of their role in the human immune system. Here we investigated long intergenic noncoding RNAs (lincRNAs) in 13 subsets of T lymphocytes and B lymphocytes by next-generation sequencing-based RNA sequencing (RNA-seq analysis) and de novo transcriptome reconstruction. We identified over 500 previously unknown lincRNAs and described lincRNA signatures. Expression of linc-MAF-4, ...
Forming an adhesive layer on a nanoimprint lithography template or a double-sided disk. Forming the adhesive layer on the double-sided disk includes immersing the double-sided disk in a liquid adhesive composition and removing the double-sided disk from the adhesive composition. The outer layer of the double-sided disk is a carbon overcoating or an intermediate layer. The adhesive composition is dried to form a first adhesion layer adhered directly to the carbon overcoating or intermediate layer on a first side of the disk and a second adhesion layer adhered directly to the carbon overcoating or intermediate layer on a second side of the disk. Forming the adhesive layer on the nanoimprint lithography template includes applying an adhesive material to the template, allowing the template to remain motionless, and rinsing a portion of the adhesive material from the template with a solvent, and drying the template.
The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer Zhaoliang Chen,1 Hong Liu,1 Huili Yang,1 Yukai Gao,1 Gongwen Zhang,1 Jiaojiao Hu2 1Department of Oncology, Binzhou Central Hospital, Binzhou, Shandong, 2Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, China Background: Accumulating evidence indicates that the long noncoding RNA, TINCR, plays a critical role in cancer progression and metastasis. However, the overall biological role and mechanisms of TINCR that were involved in human gastric cancer (GC) progression remain largely unknown.Methods: TINCR expression was measured in 56 paired tumor and adjacent nontumor tissue samples by real-time polymerase chain reaction (PCR). Insights of the mechanism of competitive endogenous RNAs (ceRNAs) were gained from bioinformatic analysis, luciferase assays. The effects of TINCR and miR-375 on GC cell apoptosis and proliferation were studied by RNA
Abstract. A digital light modulation microscope (DLMM) that utilizes a digital micromirror device (DMD) on an epifluorescence microscope has been developed to modulate excitation light in spatial and temporal domains for phosphorescence lifetime detection. Local O2 concentration can be inferred through the detected lifetime around an O2-quenching phosphorescent porphyrin microsensor. Combined with microsensor arrays, the DLMM can sequentially address light to each microsensor element to construct a discrete lifetime image or O2 distribution. In contrast to conventional phosphorescence lifetime imaging, the new method eliminates the need for a pulsed light source and a time-gated camera. To demonstrate O2 sensing with lab-on-a-chip devices, an array of 150-µm-diameter micro-wells coated with phosphorescent porphyrin were observed. The locations of the sensor elements were automatically identified though image analysis. The goal of this platform is to measure the O2 consumption of individual ...
Optical diffraction tomography using a digital micromirror device for stable measurement of 4-D refractive index tomography of ...
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are two distinct disorders caused by imprinting defects in the chromosome 15q11.2-q13 region. Unaffected individuals have one methylated allele (maternal) and one unmethylated allele (paternal).. Prader-Willi syndrome (PWS) is caused by absence of the paternal (unmethylated) allele at chromosome locus 15q11.2-q13, which causes a constellation of physical and cognitive findings. The absence of the paternal allele can be caused by a number of genetic mechanisms.. Prader-Willi syndrome occurs with a frequency of 1 in 10,000 to 1 in 30,00 births and is characterized by specific facial features (almond shaped palpebral fissures, narrowed bi-frontal diameter), significant hypotonia during infancy, and hypogonadism. Hypotonia in affected children typically improves by 2 to 3 years of age, however by early childhood most affected individuals exhibit central obesity due to hyperphagia and global developmental delay.. Angelman syndrome (AS) is a ...
Local resource for applied behavior analysis therapists in Glendale. Includes detailed information on local businesses that provide access to applied behavior analysis therapy, applied behavior analysis clinics, applied behavior analysis specialists, autism therapy, autism treatments, autism clinics, and applied behavior analysis support, as well as advice and content on autism support groups and autism societies.
I received my B.A. and M.A. in sociology from the Miami University of Ohio. My Ph.D. in sociology is from Duke University (1975) and my postdoctoral training, in aging, was performed at Duke University School of Medicine. I am a sociologist interested in social psychology, aging and adult development, medical sociology, and family relationships. I have performed extensive research in these areas. My most recent work examines social precursors of depression, the effects of stress on health, and the relationships between religion and health. I enjoy teaching Social Psychology (SOC 106/PSY 116),and graduate seminars in medical sociology and life course and aging. In 1991, I won the Trinity College Distinguished Teaching Award for my outstanding work in the classroom. I collect murder mysteries ...
Dr. Hess is a clinical pediatric psychologist, working in the areas of Child, Adolescent & Family Therapy/Development Delays. An expert in her field, Dr. Hess has over 24 years of experience. The practice is divided into two categories.
Looking for online definition of genomic imprinting in the Medical Dictionary? genomic imprinting explanation free. What is genomic imprinting? Meaning of genomic imprinting medical term. What does genomic imprinting mean?
The objective of this proposal is to determine the prognostic role of expression of Insulin-Like Growth factor II in breast cancer. IGF-II is a potent mitogen for breast tumor epithelium, and is expressed in the stroma of invasive breast cancers. In this study, we analyzed expression of IGF-II mRNA and protein in two separate series of patients with invasive breast cancer, and compared the result with other clinical parameters, prognostic indicators and patient outcome. IGF-II mRNA and protein expression were easily detected in the majority of the 193 cases that were informative and had complete clinical follow up. While analysis of the cases from the two data sets individually showed that IGF-II expression was associated with clinical outcome depending on hormone receptor status. However, IGF-II expression by itself was not a prognostic indicator, and the relationship with hormone receptor status was lost when the separate data sets were analyzed together. We were unable to prove our initial hypothesis
Free download. Book file PDF easily for everyone and every device. You can download and read online Oxford Handbook of Human Action (Social Cognition and Social Neuroscience) file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Oxford Handbook of Human Action (Social Cognition and Social Neuroscience) book. Happy reading Oxford Handbook of Human Action (Social Cognition and Social Neuroscience) Bookeveryone. Download file Free Book PDF Oxford Handbook of Human Action (Social Cognition and Social Neuroscience) at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. Its free to register here to get Book file PDF Oxford Handbook of Human Action (Social Cognition and Social Neuroscience) Pocket Guide ...
TY - JOUR. T1 - Effect of Ethanol on Insulin‐Like Growth Factor‐II Release from Fetal Organs. AU - Mauceri, Helena J.. AU - Lee, Wei‐Hua ‐H. AU - Conway, Sonya. PY - 1994/2. Y1 - 1994/2. N2 - This study examines the effect of ethanol (ETOH) exposure and nutrient restriction on the release of insulin‐like growth factor (IGF)‐II from 18‐ and 20‐day explanted fetal organs. Fetuses were exposed to ETOH (E) in utero by feeding dams a 36% (calories derived from ETOH: 6.6% v/v) ETOH liquid diet. Control fetuses were offsprings of dams either pair‐fed (P) a control liquid diet or ad libitum (A) fed a standard pelleted lab chow. Brain, heart, kidney, liver, lung, muscle, and placenta of fetuses from the same litter were pooled and explanted, and IGF‐II concentration in explanted media was analyzed by radioimmunoassay. Maternal and fetal weights were determined during pregnancy and at sacrifice, respectively, to evaluate the influence of ETOH on growth. Both maternal and fetal weights ...
Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are neurodevelopmental disorders of genomic imprinting. AS results from loss of function of the ubiquitin protein ligase E3A (UBE3A) gene, whereas the genetic defect in PWS is unknown. Although induced pluripotent stem cells (iPSCs) provide invaluable models of human disease, nuclear reprogramming could limit the usefulness of iPSCs from patients who have AS and PWS should the genomic imprint marks be disturbed by the epigenetic reprogramming process. Our iPSCs derived from patients with AS and PWS show no evidence of DNA methylation imprint erasure at the cis-acting PSW imprinting center. Importantly, we find that, as in normal brain, imprinting of UBE3A is established during neuronal differentiation of AS iPSCs, with the paternal UBE3A allele repressed concomitant with up-regulation of the UBE3A antisense transcript. These iPSC models of genomic imprinting disorders will facilitate investigation of the AS and PWS disease processes and ...
Genomic imprinting is exclusive to mammals and seed plants and refers to parent-of-origin-dependent, differential transcription. As previously shown in mammals, studies in Arabidopsis have implicated DNA methylation as an important hallmark of imprinting. The current model suggests that maternally expressed imprinted genes, such as MEDEA (MEA), are activated by the DNA glycosylase DEMETER (DME), which removes DNA methylation established by the DNA methyltransferase MET1. We report the systematic functional dissection of the MEA cis-regulatory region, resulting in the identification of a 200-bp fragment that is necessary and sufficient to mediate MEA activation and imprinted expression, thus containing the imprinting control region (ICR). Notably, imprinted MEA expression mediated by this ICR is independent of DME and MET1, consistent with the lack of any significant DNA methylation in this region. This is the first example of an ICR without differential DNA methylation, suggesting that factors ...
This would be made widespread when more becomes concerned with hythlodays educational psychology research paper to the paragraph, and the environment that he would like hythloday to read it over and correct any insights that appear in the sex. Awards can be played even especially as 20 cultures a educational psychology research paper.
Objective: This study aimed to investigate the roles of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in periodontitis.Methods: Differentially expressed lncRNAs and mRNAs between periodontitis periodontal ligament tissues and healthy periodontal ligament tissues were selected out using R project. PDLSCs were identified using flow cytometry. Western blot was employed to detect pathway relative proteins. Besides, targeted relationships between lncRNA and miRNA, as well as miRNA and mRNA were verified by dual luciferase reporter gene assay. Osteogenic differentiation of PDLSCs was assessed by alkaline phosphatase (ALP) staining and Alizarin Red Staining (ARS). Markers for osteoblast (Runx2, Osterix, Osteocalcin, Colla1) were detected using western blot.Results: LncRNA MEG3 and IGF1 were both down-regulated, while miR-27a-3p was up-regulated in periodontitis samples compared with healthy samples. Overexpression
The mannose 6-phosphate/insulin-like growth factor-II (Man-6-P/IGF-II) receptor is known to cycle between the Golgi, endosomes, and the plasma membrane. In the Golgi the receptor binds newly synthesized lysosomal enzymes and transports them directly to an endosomal (prelysosomal) compartment without traversing the plasma membrane. Deletion of the carboxyl-terminal Leu-Leu-His-Val residues of the 163 amino acid cytoplasmic tail of the bovine Man-6-P/IGF-II receptor partially impaired this function, resulting in the diversion of a portion of the receptor-ligand complexes to the cell surface, where they were endocytosed. The same phenotype was observed when 134 residues of the cytoplasmic tail were deleted from the carboxyl terminus. Disruption of the Tyr24-Lys-Tyr-Ser-Lys-Val29 plasma membrane internalization signal alone had little effect on Golgi sorting, but when combined with either deletion resulted in a complete loss of this function. The mutant receptors retained the ability to recycle to ...
Exosomes secreted by bone marrow mesenchymal stem cells (BMSCs) promote osteosarcoma cell proliferation and migration, while the underlying mechanism remains unknown. Since the long non-coding RNA PVT1 has been reported to be upregulated in osteosarcoma cells and contributes to its growth and metastasis, we aim to investigate whether BMSC-derived exosomes promote osteosarcoma growth and metastasis via transporting PVT1 into osteosarcoma cells. The PVT1 expression in BMSC-derived exosomes was markedly higher than that in osteosarcoma cell-derived exosomes. The co-culturing of BMSC-derived exosomes and osteosarcoma cells (Saos-2, MG-63, and MNNG/HOS cell lines) significantly raised PVT1 expression of osteosarcoma cells. The direct binding between PVT1 and the oncogenic protein ERG was confirmed using RNA immunoprecipitation and RNA pull-down assays, and the transported PVT1 promotes osteosarcoma cell proliferation and migration via inhibiting degradation and ubiquitination of ERG. PVT1 also increased ERG
Behavior analysts provide services to individuals, families, group homes, schools, mental health agencies, hospitals, industrial and business settings, and other agencies working with individuals who require intensive behavioral training and/or consultation. Special populations such as individuals with Autism Spectrum Disorder and other developmental disabilities have been shown to benefit greatly from Applied Behavior Analysis (ABA) services. Applied Behavior Analysis is also frequently used in the field of education for both neuro-typical students and students with disabilities. Behavior analyst professionals are strongly encouraged by the Behavior Analyst Certification Board (BACB) to pursue Board Certified Behavior Analyst (BCBA) or Board Certified Assistant Behavior Analyst (BCaBA) certification. BCBA and BCaBA certifications are considered the industry standard in this field and are nationally and internationally recognized. The Applied Behavior Analysis Certificate of Advanced Study ...
TY - JOUR. T1 - Not all insulin-like growth factor-binding proteins (IGFBPs) are detectable by western ligand blotting. T2 - Case studies of pc 12 pheochromocytoma and rat anterior pituitary igfbps and proteolyzed igfbp-3. AU - Ocrant, Ian. AU - Fay, Charles T.. AU - Pham, Hung. AU - Rosenfeld, Ron G.. PY - 1992/7. Y1 - 1992/7. N2 - We studied the limitations of the Western ligand blot (WLB) for detecting insulin-like growth factor-binding proteins (IGFBPs). PC12 rat pheochromocytoma cells and rat anterior pituitary cells (AP) secrete IGFBPs that cannot be detected by WLB. We used affinity labeling, WLB, dot blotting, competitive binding, ion exchange chromatography, and deglycosylation to characterize these IGFBPs. These IGFBPs were compared with pregnancy protease-derived IGFBP-3 fragments that also bind insulin-like growth factors (IGFs), but are not detectable by WLB. We showed that PC12 IGFBP is cationic, not glycosylated, with 25, 500 mol wt reduced (18, 500 unreduced), with high affinity ...
The CRISPR/Cas9 system provides a revolutionary genome editing tool for all areas of molecular biology. In long non-coding RNA (lncRNA) research, the Cas9 nuclease can delete lncRNA genes or introduce RNA-destabilizing elements into their locus. The nuclease-deficient dCas9 mutant retains its RNA-dependent DNA-binding activity and can modulate gene expression when fused to transcriptional repressor or activator domains.. Here, researchers from the German Cancer Research Center systematically analyze whether CRISPR approaches are suitable to target lncRNAs. Many lncRNAs are derived from bidirectional promoters or overlap with promoters or bodies of sense or antisense genes. In a genome-wide analysis, they found only 38% of 15929 lncRNA loci are safely amenable to CRISPR applications while almost two-thirds of lncRNA loci are at risk to inadvertently deregulate neighboring genes. CRISPR- but not siPOOL or Antisense Oligo (ASO)-mediated targeting of lncRNAs NOP14-AS1, LOC389641, MNX1-AS1 or HOTAIR ...
Have you ever felt insecure in your career … A Threat from Within," Personality and Social Psychology Bulletin, 28(3), 395-408. Hogan, Robert, Clinton B. …. Career Assessment Tests & Quizzes. A career assessment test helps to determine the best career option for an individual based on skills, aptitude, interest …. "Hes a big personality who is an extremely successful basketball … thats the …. you need to take a job aptitude test. These kinds of career tests can be invaluable to job seekers and established professionals alike because they show you how your personality can affect how you interact with others in a work …. Corporate Social Responsibility Interview Questions And Answers Corporate social responsibility (CSR) among small-medium enterprises … pretest interviews were conducted with two … I already know the answers to these rhetorical questions. On individual projects … ...
TY - JOUR. T1 - Effects of aromatase complex selective inhibition on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 circulating levels in breast cancer. AU - Ferrari, Leonardo. AU - Bajetta, Emilio. AU - Seregni, Ettore. AU - Martinetti, Antonia. AU - Zilembo, Nicoletta. AU - Noberasco, Cristina. AU - Buzzoni, Roberto. AU - Botti, Carlo. AU - Massaron, Simonetta. AU - Bichisao, Ettore. AU - Celio, Luigi. AU - Bombardieri, Emilio. PY - 1997. Y1 - 1997. N2 - The aim of our study is to evaluate insulin-like growth factor (IGF) and IGF binding protein (IGFBP)-3 circulating levels in postmenopausal women treated with type I aromatase inhibitor formestane for breast cancer. Sixty- three patients at their first relapse entered the trial and were randomly given formestane at 250 mg or 500 mg i.m. fortnightly. Effects of the endocrine treatment on IGF-1 and IGFBP-3 were measured before and during therapy at scheduled times. IGF-1 and IGFBP-3 seems to slightly increase in ...
Manufacturer of Ethylene Methacrylic Acid (emaa), Suppliers of Ethylene Methacrylic Acid (emaa), Dealers of Ethylene Methacrylic Acid (emaa) in Bahrain
About the Author:. Dr. David Stein is a pediatric psychologist specializing in neuropsychological testing, assessment of neurodevelopmental disorders, and behavioral and cognitive behavioral therapy. Dr. Stein is the founder of New England Neurodevelopment, LLC, in Concord, MA. He was on the faculty of Boston Childrens Hospital and an Instructor at Harvard Medical School from 2010 to 2016. Dr. Stein has spoken nationally and internationally regarding neurodevelopment and related disorders. He is the author of several scholarly articles, chapters, and this book.. Dr. Stein is a graduate of Tufts University and William James College. He completed his APA Internship in Child Psychology at Harvard Medical School/The Cambridge Hospital and his post-doctoral fellowship in Pediatric Psychology at Boston Childrens Hospital & Harvard Medical School.. ...
As of January 2018, the Applied Behavior Analysis program is not accepting applicants.**. The Department of Psychology at Central Washington University is excited to offer a Masters degree in Applied Behavior Analysis (ABA). The Behavior Analyst Certification Board, Inc.® (BACB) has approved our course sequence as meeting the coursework requirements for eligibility to take the Board Certified Behavior Analyst (BCBA) Examination®. Applicants have to meet additional requirements to fully qualify for certification. These requirements are outlined on the BACB website.. In addition to the formal coursework, the CWU ABA program arranges one academic year of supervised internship. Most students are hired by local agencies during their internship and remain with these agencies following graduation in order to complete the remaining fieldwork hours required for certification. Most students finish their fieldwork hours within 6-9 months of graduation and receive promotions as BCBAs within their ...
Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked syndrome characterized by pre- and postnatal overgrowth (gigantism), which clinically resembles the autosomal Beckwith-Wiedemann syndrome (BWS). Deletions and translocations involving the glypican-3 gene (GPC3) have been shown to be associated with SGBS. Occasionally, these deletions also include the glypican-4 gene (GPC4). Glypicans are heparan sulfate proteoglycans which have a role in the control of cell growth and cell division. We have examined the mutational status of the GPC3 and GPC4 genes in one patient with Perlman syndrome, three patients with overgrowth without syndrome diagnosis, ten unrelated SGBS-patients and 11 BWS patients. We identified one SGBS patient with a deletion of a GPC3 exon. Six SGBS patients showed point mutations in GPC3. One frameshift, three nonsense, and one splice mutation predict a loss-of-function of the glypican-3 protein. One missense mutation, W296R, changes an amino acid that is conserved in all ...
Understanding the mechanisms of vaccine-elicited protection contributes to the development of new vaccines. The emerging field of systems vaccinology provides detailed information on host responses to vaccination and has been successfully applied to study the molecular mechanisms of several vaccines. Long noncoding RNAs (lncRNAs) are crucially involved in multiple biological processes, but their role in vaccine-induced immunity has not been explored. We performed an analysis of over 2,000 blood transcriptome samples from 17 vaccine cohorts to identify lncRNAs potentially involved with antibody responses to influenza and yellow fever vaccines. We have created an online database where all results from this analysis can be accessed easily. We found that lncRNAs participate in distinct immunological pathways related to vaccine-elicited responses. Among them, we showed that the expression of lncRNA FAM30A was high in B cells and correlates with the expression of immunoglobulin genes located in its ...
View Notes - imprinting_notes from BIOSCI 137 at UC Irvine. Imprinting ©J.L.Marsh 137B November 29, 2004 page 1 IMPRINTING - THE STORY OF PRADER-WILLI & ANGELMAN SYNDROMES Phenotype(s) = rare =
Through the Loyola Clinical Centers (LCC), psychology students in the masters and doctoral program are able to hone their skills while providing services to those who couldnt typically afford it.
Although a known life-threatening complication of achondroplasia, the AAP guidelines in the timing, mode of imaging, and interpretation of the test results are poorly delineated. A series of patients were evaluated under a clinical protocol and the sleep study results were carefully analyzed to reveal a unique pattern that will likely help in the determination of the severity of central sleep apnea in this patient population.. Zarate YA, Mena R, Martin LJ, Steele P, Tinkle BT, Hopkin RJ (2009). Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocol. Am J Med Genet 149A:1691-7.. Leslie ND, Tinkle BT, Strauss AW, Shooner K, Zhang K (2009). "Very long chain acylcoenzyme A dehydrogenase deficiency" in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2010. Available at http://www.genetests.org.. Mattheis PJ, Hickey F, Tinkle BT, Hopkin R (2008). Prenatal diagnosis: beyond decisions ...
The process of X chromosome inactivation occurs as early as the blastocyst stage of embryonic life and the inactive state of the chromosome is stably maintained through subsequent cell divisions.2 X inactivation results in equalisation of X chromosome gene expression between male and female cells and is therefore considered a mechanism for dosage compensation. The inactivation process has been well documented in mice12-14 and is beginning to be understood in humans.15 A cis acting RNA transcript known as XIST (X inactivation sequence transcript) is coded from the XIC (X inactivation centre) localised to Xq13. The XIST molecule is not translated to a protein product, but rather is distributed along the length of the X chromosome to form a complex with DNA and the histone variant MacroH2A conformational shape changes to the DNA in proximity to XIST. The final step of inactivation is site specific methylation of cytosine bases.15-17 The end result of the inactivation process is to abrogate gene ...
Dr. Hsien-Sung Huang is a postdoctoral fellow in the laboratory of Dr. Benjamin Philpot where he has been since 2008. His research has identified the first compound unsilencing Ube3a in brain. Born and raised in Taiwan, Dr. Huang received his B.S. degree in pharmacy in 1998 at Taipei Medical University and his M.S. degree in biochemistry and molecular biology in 2000 at National Taiwan University. Dr. Huang went to earn his Ph.D. degree in neuroscience at the University of Massachusetts Medical School in 2008 in the laboratory of Dr. Schahram Akbarian. His thesis work has provided important insight into how chromatin remodeling at GABAergic gene promoters could contribute to the etiology of schizophrenia. He was the recipient of the NARSAD Young Investigator Award, Essel Investigator, Keystone Symposia Scholarship, NC TraC$10K Award and NC TraC$2K Award ...
The invention relates to a process for producing methacrylic acid and methacrolein, which comprises catalytically oxidizing isobutane in a gas phase in the presence of molecular oxygen to produce methacrylic acid and methacrolein in one step with a high selectivity in a high yield using a catalyst containing a heteropoly acid and having a composition of P/As-Mo-V/Cu-alkali metal/alkaline earth metal/Tl at temperatures up to 350°C, preferably up to 320°C, at which said heteropoly acid difficultly decomposes, to thereby maintain the catalytic activity for a long time. It is important for the catalyst to contain a combination of V and/or Cu and at least one of alkali metal, alkaline earth metal and Tl.
Overgrowth syndromes in children constitute a group of rare disorders that are typical of tissue hypertrophy. Individual overgrowth syndromes have been shown to overlap with regard to clinical and radiologic features. The details of the genetic bases of these syndromes are unfolding. Any of the three embryonic tissue layers may be involved.The syndromes may manifest in localized or generalized tissue overgrowth. Latitudinal and longitudinal growth may be affected. Nevertheless, the musculoskeletal features are central to the diagnosis of some syndromes such as Proteus syndrome. The time of presentation of children with overgrowth syndromes is an important contributor to the differential diagnosis. Children with some overgrowth syndromes such as Klippel-Trenaunay-Weber syndrome can be readily detectable at birth. In contrast other overgrowth syndromes such as Proteus syndrome usually present in the postnatal period characteristically between the 2nd and 3rd year of life. In general, children with ...
american society of gene therapy, gene therapy, gene research, genes, chromosomes, units of heredity, cancer gene therapy, gene therapy systems, gene delivery, gene therapy research, biotechnology, human gene therapy, germ-line, cellular and gene therapy, european society of gene therapy, gene therapy research, aarskog syndrome, aase syndrome, ablepharon-macrostomia syndrome, acoustic neuroma, adie syndrome, adrenal hyperplasia, adrenoleukodystrophy, aicardi syndrome, alagille syndrome, albinism, alkaptonuria, alopecia areata, alpha-1 antitrypsin deficiency, alstrom syndrome, angelman syndrome, apert syndrome, arthrogryposis, ataxia, autism, bardet-biedl syndrome, barth syndrome, batten, beckwith-wiedemann syndrome, canavan, celiac, cerebrocostomandibular syndrome, charcot-marie-tooth disease, cleidocranial dysplasia, cockayne syndrome, coffin lowry syndrome, congenital cardiovascular disorders, congenital heart disease, congenital musculoskeletal disorders, congenital neurological disorders, congenital
Insulin-like growth factor-binding protein 6 contains a PF00086 domain.. Insulin-like growth factor-binding protein 6 contains a PF00219 domain.. Insulin-like growth factor-binding protein 6 is proteolytically cut by matrix metallopeptidase-2 (M10.003) cleavage. CLRR-EGQP.. ...
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF- I and IGF-II. IGF-BP-6 plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.Human recombinant IGF-BP-6 produced in E. coli is a single, non-glycosylated polypeptide chain containing the amino acids 148-240 and having a molecular mass of 20 kDa including a 4 kDa His tag. It is purified by using proprietary chromatographic techniques ...
A preauricular sinus (also known as a congenital auricular fistula, a congenital preauricular fistula, a Geswein hole, an ear pit, or a preauricular cyst) is a common congenital malformation characterized by a nodule, dent or dimple located anywhere adjacent to the external ear. Frequency of preauricular sinus differs depending the population: 0.1-0.9% in the US, 0.9% in the UK, and 4-10% in Asia and parts of Africa. Comparative frequency is known to be higher in Africans and Asians than in Caucasians. Preauricular sinuses are inherited features, and most often appear unilaterally. They are present bilaterally in 25-50% of cases.[citation needed] Preauricular sinuses and cysts result from developmental defects of the first and second pharyngeal arches. This and other congenital ear malformations are sometimes associated with renal anomalies. They may be present in Beckwith-Wiedemann syndrome, and in rare cases, they may be associated with branchio-oto-renal syndrome.[citation needed] ...
Title of Dissertation: FUNCTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7(IGFBP7) IN HEPATOCELLULAR CARCINOMA By Dong Chen. Purpose: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with no effective treatment, thus requiring the development of innovative and effective targeted therapies. The oncogene Astrocyte Elevated Gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis and profoundly downregulates Insulin-like Growth Factor Binding Protein-7 (IGFBP7). The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function. Experimental Design: IGFBP7 expression was detected by immunohistochemistry in HCC tissue microarrays by real-time PCR and ELISA in human HCC cell lines. Dual Fluorescence in situ hybridization was performed to detect loss of heterozygosity at the IGFBP7 locus. Stable IGFBP7- overexpressing clones were established in the background of AEG-1- overexpressing human
Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent; however, whether lncRNAs play roles in cancer resistance in this seductive species remains unknown. In this study, we developed a pipeline and identified a total of 4422 lncRNAs across the NMR genome based on 12 published transcriptomes. Systematic analysis revealed that NMR lncRNAs share many common characteristics with other vertebrate species, such as tissue specificity and low expression. BLASTN against with 1057 human cancer-related lncRNAs showed that only 5 NMR lncRNAs displayed homology, demonstrating the low sequence conservation between NMR lncRNAs and human cancer-related lncRNAs. Further correlation analysis of lncRNAs and protein-coding genes indicated that a total of 1295 lncRNAs were intensively
The professional practice of behavior analysis is one domain of behavior analysis: the others being radical behaviorism, experimental analysis of behavior and applied behavior analysis. The professional practice of behavior analysis is the delivery of interventions to consumers that are guided by the principles of behaviorism and the research of both the experimental analysis of behavior and applied behavior analysis. Professional practice seeks maximum precision to change behavior most effectively in specific instances. Behavior analysts are mental health professionals and, in some states, may hold a license, certificate or registration as a behavior analyst. In other states, there are no laws governing their practice and, as such, the practice may be prohibited as falling under the practice definition of other mental health professionals. This is rapidly changing as Behavior Analysts are becoming more and more common. The professional practice of behavior analysis is a hybrid discipline with ...
TY - JOUR. T1 - Gene expression profile in cerebrum in the filial imprinting of domestic chicks (Gallus gallus domesticus). AU - Yamaguchi, Shinji. AU - Fujii-Taira, Ikuko. AU - Katagiri, Sachiko. AU - Izawa, Ei Ichi. AU - Fujimoto, Yasuyuki. AU - Takeuchi, Hideaki. AU - Takano, Tatsuya. AU - Matsushima, Toshiya. AU - Homma, Koichi J.. PY - 2008/6/15. Y1 - 2008/6/15. N2 - In newly hatched chicks, gene expression in the brain has previously been shown to be up-regulated following filial imprinting. By applying cDNA microarrays containing 13,007 expressed sequence tags, we examined the comprehensive gene expression profiling of the intermediate medial mesopallium in the chick cerebrum, which has been shown to play a key role in filial imprinting. We found 52 up-regulated genes and 6 down-regulated genes of at least 2.0-fold changes 3 h after the training of filial imprinting, compared to the gene expression of the dark-reared chick brain. The up-regulated genes are known to be involved in a ...
Patients at the NJ Craniofacial Center of Morristown benefit from the multidisciplinary expertise of surgical and medical pediatric specialists who share a commitment to using new technology and medical advances for patients and education and support for their families. We offer specialized programs in patients with moderate to severe craniofacial disorders and also mild craniofacial disorders, plagiocephaly and/ or torticollis.. At our Comprehensive Team Meeting, all members of the craniofacial team meet to evaluate a child with moderate to severe craniofacial disorders. We are proud to have a Pediatric Psychologist as part of our team. The craniofacial teams psychologist will assess your childs development and will offer support and treatment to both you and your child. As your child ages, craniofacial disorders will have a varying impact on his or her life as well as the life of your family. For younger children, our psychologist will assess your childs developmental level, refer you for ...
Find Positive Psychology Therapists, Psychologists and Positive Psychology Counseling in Alaska, get help for Positive Psychology in Alaska.
NEW YORK - Children and adolescents with obsessive compulsive disorder (OCD), anxiety or tic disorders are being treated in a new specialized outpatient clinic at NewYork-Presbyterian Hospital/Weill Cornell Medical Center - one of the only programs of its kind in the New York metro area.. In addition to a clinic in Manhattan, the Pediatric OCD, Anxiety and Tic Disorders (POCAT) program will offer a unique, day camp-style intensive summer treatment program situated in White Plains, N.Y., at NewYork-Presbyterian Hospital/Westchester Division. The POCAT program is co-led by pediatric psychologist Dr. Shannon M. Bennett and psychiatrist Dr. Justin Mohatt.. "Anxiety is a normal part of growing up, but when it interferes with school, friendships or family life, we recommend parents seek treatment for their child. If a family is going to extreme measures to accommodate their childs anxiety, or if their child has a problem with involuntary movements or vocalizations, we can offer help," says Dr. ...
Dr Georg Auzinger is a Consultant and Reader in Intensive Care Medicine and the Clinical Director for Critical Care at Kings College Hospital NHS Foundation Trust. He graduated from the Medical School of the University of Innsbruck in 1990. He trained in Internal Medicine in Austria, followed by Specialist Intensive Care training at the Alfred Hospital in Melbourne, Australia. The Alfred Hospital is a quaternary referral institution for Major Trauma, Heart and Lung Transplantation, Extracorporeal Cardiac and Respiratory Support, Burns and Hyperbaric Medicine. In 2002 he was appointed as a Consultant Intensivist at Kings College Hospital for General and Liver Intensive Care Units (ICUs). He was the Lead Clinician for the Liver ICU from 2007 until 2015, when he was appointed Clinical Director for Critical Care at Kings.. Doctor Auzinger has special interests in extracorporeal cardio-respiratory assist, acute liver failure, liver transplantation, ARDS, fungal infection, and TEE and TTE in ...
Acheter Generic Ponstel Us, What Does Ponstel Cost, Safe Buy Generic Mefenamic acid, Lowest Cost Ponstel, Combien Cheap Ponstel Washington, Where To Buy Generic Ponstel Us, Reliable Place Buy Ponstel, Combien Cheap Ponstel Norge, Beställ Online Ponstel Odense, Buy Online Ponstel Norway, Cheapest Ponstel Internet, Combien Online Ponstel Japan, Safe Place To Buy Mefenamic acid Online, Buy Generic Ponstel Sverige, Acheter Mefenamic acid Internet Sans Risque, Buy Mefenamic acid Legally Online, Köp Online Ponstel Stockholm, Purchase Real Ponstel, Purchase Ponstel Online Pharmacy, Where To Buy Online Ponstel Belgique, Achat Mefenamic acid Generique En Ligne, Buy Cheap Genuine Mefenamic acid, Cheap Generic Ponstel Online, Best Pharmacy To Buy Mefenamic acid, Purchase Cheap Ponstel Denmark, Cost Daily Mefenamic acid, Acheter Generic Ponstel Toronto, Achat Generic Ponstel Sweden, Ponstel Online To Buy, Ponstel Cheap Discount, Where To Order Cheap Ponstel Europe, Buy Discount Ponstel Online, Achat ...
Prostate Cancer Risk in Relation to a Single Nucleotide Polymorphism in the Insulin-like Growth Factor-binding Protein-3 (IGFBP3) Gene: a Meta-analysis IGFBP3;prostate cancer;polymorphism;meta-analysis; Insulin-like growth factor-binding protein-3 (IGFBP3) has been identified as a putative tumor suppressor with multifunctional roles in the IGF axis. Recently, there have been a growing body of studies investigating the relation between the IGFBP3 A-202C polymorphism, circulating IGFBP3 and prostate cancer risk, but their outcomes varied leading to controversy. Hence, it is necessary to perform a meta-analysis covering all eligible studies to shed a light on the association of IGFBP3 A-202C and cancer risk. Finally, we included a total of 11 relevant articles between 2003 and 2010 covering 14 case-control studies including 9,238 cases and 8,741 controls for our analysis. Our results showed that A-202C was a marginal risk factor of prostate cancer (allele contrast: OR=1.08, 95% CI :1.01-1.16; dominant
In these population based data from central and eastern Europe, we found that all indicators of alcohol intake and problematic drinking were associated with effort-reward imbalance but not with job control. The association with effort-reward imbalance was independent of deprivation and education but some of it was related to depressive symptoms.. Alcohol accounts for a substantial burden of ill health in the region, especially in the former Soviet Union.20,35 The social and health impact of alcohol in the region is at least partly related to the pattern of binge drinking.21,36 It is therefore important to understand the distribution of drinking and alcohol related problems in the population. Alcohol intake has previously been found to be associated with education and marital status in Russia37 and with education in the Czech Republic38 and Poland (unpublished data). Psychosocial factors are often thought to be at least partly responsible for the association between socioeconomic position and ...
The aim of this module is to provide the student with tangible experience of applying psychology theory to practice. Rather than focus on psychopathology, the module focuses on utilising established positive psychology approaches in supporting psychological growth, well-being and resilience. During the first half of the module, students will study the theoretical underpinnings of positive psychology and will work in small groups to design a positive psychology well-being intervention. During the final half of the module, the well-being intervention will be delivered to fellow undergraduate student across all years. Skills gained in this module will support future applications for assistant psychology posts in addition to other support roles with the aim of pursuing a career as a psychologist. Skills gained in this module are also applicable to other established careers such as social work, nursing, occupational therapy or further academic study (e.g. PhD). The module is a unique opportunity to ...
This study is to investigate if intranasal oxytocin will improve hyperphagia, social skills, and behaviors in subjects with Prader-Willi syndrome. This will be a randomized placebo controlled pilot study. The primary outcome measure is to determine if intranasal administration of oxytocin will cause any adverse events in subjects with Prader-Willi syndrome. Secondarily, the investigators will also perform evaluations to determine if intranasal oxytocin has any effect on social skills, behaviors, or appetite in children with Prader-Willi syndrome ...
We have begun to unravel the mechanisms by which the lncRNA Kcnq1ot1 regulates allelic expression of a cluster of genes in the Kcnq1 imprinting domain. Using two complementary approaches, we demonstrate that Kcnq1ot1 lncRNA interacts directly with chromatin to form a 200-kb intrachromosomal loop between the downstream Kcnq1 promoter and the KvDMR1where the Kcnq1ot1 promoter is located.. First, we developed an R3C method to examine this RNA-chromatin DNA interaction. The Kcnq1ot1 lncRNA that was interacting with chromatin was reverse transcribed into double-stranded cDNA. After restriction enzyme digestion, the sticky ends from the Kcnq1ot1 cDNA and the interacting chromatin DNA were ligated, and the chimeric products were identified after PCR amplification. To confirm this lncRNA-DNA interaction, we also used a ChOP method (Mariner et al., 2008; Pandey et al., 2008) to detect enrichment of Kcnq1ot1 lncRNA at the Kcnq1 promoter and KvDMR1 regions. The Kcnq1ot1 lncRNA was pulled down with ...
miniaturization of integrated circuits using nanotechnology - 28 images - miniaturization of integrated circuits using nanotechnology 28 images traditional, integrated circuits miniaturization 28 images thermal characterization of carbon nanotube, integrated circuits miniaturization 28 images thermal characterization of carbon nanotube, integrated circuits nanotechnology 28 images integrated circuits nanotechnology 28 images, integrated circuits miniaturization 28 images thermal characterization of carbon nanotube
Our research looks at what studying strategies undergraduate students with disabilities use to learn, why they use some strategies over others, and what metacognitive awareness is involved in these decisions. Previous research has shown that, while practicing information retrieval through self-testing is extremely beneficial to learning, many students tend to use the strategy of repeated reading, which does little in the way of learning more after the initial reading, and the importance of engaging in metacognitive awareness becomes apparent (Karpicke, Butler, & Roediger, 2009).We are looking for a deeper understanding of the connections between metacognitive awareness of learning, working memory, and learning for undergraduate students with disabilities, and how metacognitive strategies can possibly be applied. The participants are undergraduate students at the University of North Florida who are registered with the campus Disability Resource Center (N=400), with students who are a part of the Access
Supramolecular assemblies involving interaction of a small organic molecule, 2-hydroxy-6-Naphthoic acid (HNA), with poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP) diblock copolymers are utilized to obtain micellar structures in solution, nanostructured thin films on flat substrates and, finally, nanoporous thin films. The formation of hydrogen bonds between HNA and the poly(4-vinylpyridine) (P4VP) blocks is confirmed by spectroscopic measurements. The accordingly P4VP/HNA hydrogen-bonded complexes are poorly soluble in 1,4-dioxane, resulting in the formation of micellar structures with a P4VP/HNA core and a polystyrene (PS) corona. Those micelles have been spin-coated onto silicon wafers, resulting in nanostructured thin films consisting of P4VP/HNA dot-like features embedded in a PS matrix. The morphology of those films has been tuned by solvent annealing. Selective dissolution of HNA by methanol results in the formation of a nanoporous thin film. The P4VP/HNA nanodomains have been also
Dr. Derek Reed is a Licensed Behavior Analyst in the State of Kansas and an Associate Professor in the Department of Applied Behavioral Science at the University of Kansas where he directs the Applied Behavioral Economics Laboratory. Derek received his Bachelors degree in Psychology from Illinois State University and his Masters and Ph.D. in School Psychology from Syracuse University. He has served as Associate Editor for Behavior Analysis in Practice and The Psychological Record, and guest Associate Editor for The Behavior Analyst, Journal of Behavioral Education, and Journal of Applied Behavior Analysis. He serves as a reviewer on the editorial boards of The Behavior Analyst, Journal of Applied Behavior Analysis, and Journal of the Experimental Analysis of Behavior. Derek has published over 90 peer reviewed papers and book chapters, coauthored three edited books, and was the 2016 recipient of the American Psychological Association Division 25 B. F. Skinner Foundation New Applied Researcher ...
The type I insulin-like growth factor (IGF) receptor (IGF1R) is a transmembrane tyrosine kinase involved in breast cancer proliferation, survival, and metastasis. Several monoclonal antibodies directed against the receptor are in clinical trials. In
A. All the time, and a lot of them get relief from it. The one I send them to most often happens to be a doctor who got into acupuncture later. Theres a large Asian population in the Berkeley area, so there are many acupuncturists to choose from. But the results are variable. Some people get really good results from acupuncture or acupressure, and others find its a waste of time. So its something to have in your therapeutic armamentarium. Particularly if nothing else is working, give it a try!. Q. What about the "psychosocial factors" involved in low back pain?. A. Thats a tough one, because as soon as doctors say "psychosocial factors," patients wonder, "do you think this is all in my head, doc?" But it is nonetheless true that pain and psychosocial factors are hard to uncouple. For example, I see a lot of patients who have repetitive strain injuries, and any time you have a chronic injury, theres the possibility that it will be linked with either depression or stress. And what caused what ...
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene ...
Beckwith-Wiedemann syndrome (BWS) is a growth disorder variably characterized by neonatal hypoglycemia, macrosomia, macroglossia, hemihyperplasia, omphalocele, embryonal tumors (e.g., Wilms tumor, hepatoblastoma, neuroblastoma, and rhabdomyosarcoma), visceromegaly, adrenocortical cytomegaly, renal abnormalities (e.g., medullary dysplasia, nephrocalcinosis, medullary sponge kidney, and nephromegaly), and ear creases/pits. BWS is considered a clinical spectrum, in which affected individuals may have many of these features or may have only one or two clinical features. Early death may occur from complications of prematurity, hypoglycemia, cardiomyopathy, macroglossia, or tumors. However, the previously reported mortality of 20% is likely an overestimate given better recognition of the disorder along with enhanced treatment options. Macroglossia and macrosomia are generally present at birth but may have postnatal onset. Growth rate slows around age seven to eight years. Hemihyperplasia may affect segmental
0043] The anionic fixing polymers containing carboxylic groups that are preferred according to the invention are: [0044] A) acrylic or methacrylic acid copolymers, or salts thereof and in particular the products sold under the names Ultrahold® by the company BASF, the copolymers of acrylic acid and of acrylamide sold in the form of their sodium salt under the names Reten 421, 423 or 425 by the company Hercules, the sodium salts of polyhydroxycarboxylic acids; [0045] B) copolymers of acrylic or methacrylic acids with a monoethylenic monomer such as ethylene, styrene, vinyl esters, acrylic or methacrylic acid esters, optionally grafted onto a polyalkylene glycol such as polyethylene glycol and optionally crosslinked. Such polymers are described in particular in French patent 1 222 944 and German patent application 2 330 956, the copolymers of this type comprising an optionally N-alkylated and/or N-hydroxyalkylated acrylamide unit in their chain as described in particular in Luxembourg patent ...
There are many causes of seizures. The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to happen at a particular time, or how often seizures occur. Malnutrition and overnutrition may increase the risk of seizures. Examples include the following: Vitamin B1 deficiency (thiamine deficiency) was reported to cause seizures, especially in alcoholics Vitamin B6 depletion (pyridoxine deficiency) was reported to be associated with pyridoxine-dependent seizures. Vitamin B12 deficiency was reported to be the cause of seizures for adults and for infants. Folic acid in large amounts was considered to potentially counteract the antiseizure effects of antiepileptic drugs and increase the seizure frequency in some children, although that concern is no longer held by epileptologists. Those with various medical conditions may suffer seizures as one of their symptoms. These include: Angelman syndrome Arteriovenous ...
Health Beauty About Us Diet & Fitness Eating Health A-Z Healthy Living Love & Family Medicine Mental Health Policy & Industry Recipes Weight Loss Sitemap Recent site activity Amenorrhea Ankylosing spondylitis Aplastic anemia, Amnesia Anorexia nervosa Appendicitis, Amyloidosis Anorgasmia ARDS, Amyotrophic lateral sclerosis Anthrax Arteriosclerosis / atherosclerosis, Anal cancer Antibiotic-associated diarrhea Arteriovenous fistula, Anal fissure Antiphospholipid syndrome Arthritis, Anal itching Antisocial personality disorder Asbestosis, Anaphylaxis Anxiety Ascariasis, Anemia Aortic dissection Aspergers syndrome, Angelman syndrome Aortic valve regurgitation Aspergillosis, Angina Aortic valve stenosis Asthma, Anhidrosis Aphasia Asthma attack Astigmatism Atrial fibrillation Autism, Ataxia Atrial septal defect (ASD) Autoimmune hepatitis, Atelectasis Atrioventricular canal defect Autonomic neuropathy, Athletes foot Atypical depression Avascular necrosis, Atopic dermatitis (eczema) Atypical hyperplasia of the
Shoulder pain is a common secondary condition in people with spinal cord injury (SCI) that often results in loss of function and of independence and imposes limitations on self-care, work, and leisure activities, and leads to decreased quality of life. More than 40% of individuals with SCI report shoulder pain at the beginning of inpatient rehabilitation; this number increases to 50% at hospital discharge. The onset of shoulder pain within the first year after injury may lead to lifelong chronic shoulder pain. Although information is known about shoulder pain in patients with long-term SCI, little is known about the beginning of shoulder problems and how they progress early after the injury. In addition to physical problems, psychosocial factors are also associated with chronic pain.. This study will investigate the progression of musculoskeletal (shoulder muscle flexibility, muscle strength, movement coordination, and rotator cuff health) and psychosocial (fear of movement, pain ...
1. Klein R, Peto T, Bird A, Vannewkirk MR. The epidemiology of age-related macular degeneration. American journal of ophthalmology. 2004;137:486-95 2. Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Survey of ophthalmology. 2003;48:257-93 3. van Wijngaarden P, Qureshi SH. Inhibitors of vascular endothelial growth factor (VEGF) in the management of neovascular age-related macular degeneration: a review of current practice. Clin Exp Optom. 2008;91:427-37 4. Ferrara N. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat Med. 2010;16:1107-11 5. Kovach JL, Schwartz SG, Flynn HW Jr, Scott IU. Anti-VEGF Treatment Strategies for Wet AMD. J Ophthalmol. 2012;2012:786870 6. Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016;15:385-403 7. Park YG, Rhu HW, Kang S, Roh YJ. New Approach of Anti-VEGF Agents ...
NIH Rare Diseases : 52 Proximal chromosome 18q deletion syndrome is a chromosome abnormality that occurs when there is a missing (deleted ) copy of genetic material from the part of the long (q) arm near the center of chromosome 18 . The severity of the condition and the signs and symptoms depend on the size and location of the deletion and which genes are involved. Features that often occur in people with proximal chromosome 18q deletion syndrome include developmental delay , intellectual disability , and distinctive facial features. The might also have seizures , low muscle tone (hypotonia ), speech and language delays, obesity, and short stature . Chromosome testing of both parents can provide more information on whether or not the deletion was inherited . In most cases, parents do not have any chromosomal anomaly. However, sometimes one parent is found to have a balanced translocation , where a piece of a chromosome has broken off and attached to another one with no gain or loss of genetic ...
Victoria Clarke is a senior lecturer in social psychology at the University of the West of England, Bristol, UK. She has published a number of papers on lesbian and gay parenting, same-sex relationships, the history of LGBTQ psychologies, and qualitative methods in journals such as Sexualities, British Journal of Social Psychology, Qualitative Research in Psychology and Lesbian & Gay Psychology Review. She has edited (with Sara-Jane Finlay and Sue Wilkinson) two special issues of Feminism & Psychology on marriage, and edited (with Elizabeth Peel) special issues of Feminism & Psychology, Journal of Gay & Lesbian Psychotherapy, Lesbian & Gay Psychology Review and Psychology of Women Section Review on LGBTQ psychologies. She is also the editor with Elizabeth Peel and Jack Drescher of British LGB Psychologies: Theory, research and practice (Haworth Press, 2007). She is a member of the British Psychological Societys Lesbian & Gay Psychology Section and Qualitative Methods in Psychology Section. She ...
Human beings are social organisms with an intrinsic desire to seek and participate in social interactions. Social anhedonia is a personality trait characterized by a reduced desire for social affiliation and reduced pleasure derived from interpersonal interactions. Abnormally high levels of social anhedonia prospectively predict the development of schizophrenia and contribute to poorer outcomes for schizophrenia patients. Despite the strong association between social anhedonia and schizophrenia, the neural mechanisms that underlie individual differences in social anhedonia have not been studied and are thus poorly understood. Deficits in face emotion recognition are related to poorer social outcomes in schizophrenia, and it has been suggested that face emotion recognition deficits may be a behavioral marker for schizophrenia liability. In the current study, we used functional magnetic resonance imaging (fMRI) to see whether there are differences in the brain networks underlying basic face ...
I attended a very good lecture last week on contemporary views of countertransference. It inspired me to write a brief overview of the concept here, with more to follow.. To understand countertransference, it helps to tackle transference first. Transference was a word coined by Sigmund Freud to label the way patients "transfer" feelings from important persons in their early lives, onto the psychoanalyst or therapist. Psychoanalysis was specifically designed to encourage transference. Intentional opacity and non-disclosure by the therapist promotes transference; the patient naturally makes assumptions about the therapists likes and dislikes, attitude toward the patient, life outside the office, and so forth. These assumptions are based on the patients experiences with, and assumptions regarding, other important relationships, such as childhood relations with parents. In this way the patients formative dynamics are re-created in the therapy office for both participants to observe. Patients ...
A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo). Heterozygosity of the sequenced source genome allowed discovery of more than 600,000 high quality single nucleotide variants. Despite this heterozygosity, the current genome assembly (,1.1 Gb) includes 917 Mb of sequence assigned to specific turkey chromosomes. Annotation identified nearly 16,000 genes, with 15,093 recognized as protein coding and 611 as non-coding RNA genes. Comparative analysis of the turkey, chicken, and zebra finch genomes, and comparing avian to mammalian species, supports the characteristic stability of avian genomes and identifies genes unique to the avian lineage. Clear differences are seen in number and variety of genes of the avian immune system where expansions and novel genes are less frequent than examples of gene loss. The turkey genome ...
Douglas Weiss, Ph.D. is an author, speaker, licensed psychologist, and marriage counselor who specializes in sexual issues. He is also the founder and president of the American Association for Sex Addiction Therapy, as well as the clinical director of the Heart to Heart Counseling Center in Colorado Springs, Colorado. He has written over forty books on self-help and sexual and marital issues, including sexual anorexia. Weiss received a Bachelor of Arts in Pastoral Ministries from United Wesleyan College, a dual masters degree in Divinity and in Marriage and Family Counseling from Southwestern Baptist Theological Seminary, as well as a doctorate in Psychology from North Central University. He has been married to his wife Lisa, his business partner and co-worker at the Heart to Heart Counseling Center, for over twenty-five years and they have two children. Weiss has stated that he suffered from sexual addiction throughout his teenage years and young adulthood and has identified his past as the ...
The webinar will be available to members of Pharmacist Society and Generation NP, two online social media communities created by Skipta, the premier closed-loop social networking platform for medical professionals. This webinar, the latest in an on-going series, is part of CRNs initiative to help ensure that healthcare practitioners have access to science-based information on dietary supplements and the supplement industry. The webinar will be held Dec. 10, from 2-3 p.m., EST, and will be co-presented by Taylor Wallace, senior director, scientific and regulatory affairs, CRN, and Andrea Singer, associate professor, Medicine and Obstetrics & Gynecology at Georgetown University Medical Center and clinical director of the National Osteoporosis Foundation. The webinar will review updated recommendations for calcium and vitamin D intake and explore the role of calcium in bone health as well as other non-skeletal benefits. Wallace and Singer will examine research on the two nutrients, including ...
Introduction. Behaviourism originated with the work of John B. Watson from 1913. Behaviourism is based on the following sets of claims: (1) Psychology is the study of behaviour. Psychology is not the science of mind. This statement also forms a type of behaviourism: Methodological behaviourism claims that psychology should concern itself with the behaviour of organisms (human and non-human). Psychology should not concern itself with mental states or events or with constructing internal information processing accounts of behaviour. In its historical foundations, methodological behaviourism shares with analytical behaviourism the influence of positivism. One of the goals of positivism was to unify psychology with natural science. Methodological behaviourism is a dominant theme in the writings of John Watson. John Broadus Watson was one of the most prominent psychologist scientists of his era, writing on applied psychology for academic journals, business publications, and popular magazines and is ...
Dr Salisbury qualified from University College London in 1980 and trained as a pathologist at University College Hospital London and Kings College Hospital London. He was appointed as Clinical Senior Lecturer to Kings College School of Medicine & Dentistry and Honorary Consultant Histopathologist to Kings College Hospital in 1987 and promoted to Reader in Histopathology in 1997. He was Clinical Director of Histopathology from 1997 to 2004 and was appointed Head of the Clinical Service in 2011.. Dr Salisbury is the joint lead of the Clinical Academic Department of Cellular Pathology and a member of the Cancer Clinical Academic Group Executive Board of Kings Health Partners.. Dr Salisburys specialist interests are in haematopathology, dermatopathology, autopsy pathology and osteoarticular pathology. He has written two books (on bone and joint diseases and on molecular pathology), several book chapters and over 140 articles in academic journals.. ...
BACKGROUND: Silver-Russell syndrome (SRS) is a clinically and genetically heterogeneous condition characterized by severe intrauterine and postnatal growth retardation. Loss of DNA methylation at the telomeric imprinting control region 1 (ICR1) on 11p15 is an important cause of SRS. METHODS: We studied the methylation pattern at the H19-IGF2 locus in 201 patients with suspected SRS. In an attempt to categorize the patients into different subgroups, we developed a simple clinical scoring system with respect to readily and unambiguously assessable clinical features. In a second step, the relationship between clinical score and epigenetic status was analyzed. Results and CONCLUSIONS: The scoring system emerged as a powerful tool for identifying those patients with both a definite SRS phenotype and carrying an epimutation at 11p15. 53% of the 201 patients initially enrolled fulfilled the criteria for SRS and about 40% of them exhibited an epimutation at the H19-IGF2 locus. Methylation defects were ...
Expert: Dr. Brian Iwata received his Ph.D. in psychology from Florida State University and subsequently held positions at Western Michigan University and the Johns Hopkins University School of Medicine. He is Distinguished Professor in Psychology and Psychiatry at the University of Florida, where he also has directed the Florida Center on Self-Injury and the Prader-Willi Syndrome Program. Brian is the former chief editor of the Journal of Applied Behavior Analysis and former president of the Association for Behavior Analysis, the Society for the Advancement of Behavior Analysis, the Society for the Experimental Analysis of Behavior, Division 33 of the American Psychological Association, and the Florida Association for Behavior Analysis. His primary areas of interest are disorders of learning and behavior and research methodology. He has published over 240 articles and chapters on these topics, and he has received $7 million in research grants to support that work. Much of Dr. Iwatas research ...
This study investigated the psychological wellbeing and body perception among young Italian people. Drinking, eating, and sexual behaviors have been examined in relation to body mass index (BMI) and psychological well-being by EPOCH framework. This was a cross-sectional observational study conducted on Italian adolescent and young adult population through an online survey. Qualitative and quantitative data on lifestyle, BMI classes, and psychological characteristics of wellness in youth were obtained from a sample of 1221 Italian participants using a self-report questionnaire on body perception and habits, a socio-demographics inventory, and the EPOCH measure. Findings suggest that being underweight or overweight is associated with various factors, including gender, self-control regarding food, perception of ones body, and the happiness domain. EPOCH framework revealed the psychological wellness of girls and young women did not seem strongly affected by BMI, though Perseverance and Happiness ...
X-inactivation (also called lyonization) is a process by which one of the copies of the X chromosome present in female mammals is inactivated. The inactive X chromosome is silenced by its being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation). The choice of which X chromosome will be inactivated is random in placental mammals such as humans, but once an X chromosome is inactivated it will remain inactive throughout the lifetime of the cell and its descendants in the organism. Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally derived X chromosome. In 1959 Susumu Ohno showed that the two X-chromosomes of mammals were different: one appeared similar to the ...
Thanks to the ever larger penetration of the Internet and especially with the advent of Web 2.0 and social media, hoaxes, rumours and urban legends have become an almost everyday occurrence. While social psychology research contends that rumors can negatively impact on the public by generating distress, intense fear, anxiety, possibly resulting in herd behaviour and violence [1], there is evidence that disease-related rumours may alter health-related behaviors and interfere with medical decision-making [2]. Medical misinformation is most frequently associated with collective emergency situations (e.g., Ebola infected patients refused to be hospitalized because of rumours that international health care workers intentionally brought the virus with them [3]; people from around Kenema, Sierra Leone attacked the hospital after hearing rumours of conspiracy [4]; during the 2011 Fukushima nuclear disaster in Japan, rumours that ingestion of iodized salt could prevent radiation damage lead to a shortage ...
The Reading the Mind in the Eyes Test: A Portuguese version of the adults test. O Reading the Mind in the Eyes Test: Uma versão portuguesa do teste para adultos. José Pestana*1, Sofia Menéres*2, Maria João Gouveia2, Rui Filipe Oliveira3. 1ISPA - Instituto Universitário, Lisboa, Portugal. 2ISPA - Instituto Universitário, APPsyCI-Applied Psychology Research Center Capabilities & Inclusion, Lisboa, Portugal. 3Departamento de Biociências, ISPA - Instituto Universitário, Lisboa, Portugal / Instituto Gulbenkian de Ciência, Lisboa, Portugal / Champalimaud Center for the Unknown, Neurosciences, Lisboa, Portugal. Correspondência. ABSTRACT. The Reading the Mind in the Eyes Test (RMET) is a Theory of Mind task that assesses the ability to understand others mental states in both healthy and clinical populations. The goal of the present study was to translate the revised version of the adults RMET to the Portuguese (European) language, investigate item validity for this version and differences ...
DNA methylation of the CpG dinucleotide is one of the most crucial epigenetic modifications in mammals [1]. Its feature is a modification of the 5-position of the pyrimidine ring of cytosine that produces 5-methylcytosine (5mc). A large body of literature demonstrates that the level of genome-wide DNA methylation (also is referred to as overall DNA methylation) changes dynamically during the course of normal development, and this epigenetic regulation is critical in the determination of cell fate during embryogenesis [2, 3]. For example, during the preimplantation stage, the mammalian genome becomes progressively demethylated, which is associated with the initiation of cellular differentiation of somatic cells [3].. On the contrary, impairment of methylation can damage assorted aspects of gene regulation, such as X chromosome inactivation [1], genomic imprinting [4] and retroviral silencing [5]. Additionally, environmental factors, such as ionizing radiation [6] and hormone exposure [7], could ...
Experimental psychology emerged as a modern academic discipline in the 19th century when Wilhelm Wundt introduced a mathematical and experimental approach to the field.Introduction to Experimental Psychology Consciousness (Chapter 3 in Myers) Consciousness as a process: The study of consciousness has a frustratingly long history in.Introduction to Educational Psychology What is Educational Psychology.Experimental psychology is an approach to psychology that treats it as one of the natural sciences, and therefore assumes that it is susceptible to the experimental.. The birth of experimental psychology as a discipline in its own right is often dated from the appearance of Wilhelm Wundts great handbook, the Grundzüge der...Introduction to the basic topics of psychology, including learning, motivation, cognition, development, abnormal, physiological, social, and personality ...
The invention is directed to an improvement in a process for preparing an aqueous emulsion of pressure-sensitive adhesive based upon acrylic esters having a good balance of adhesive and cohesive properties and to the resulting emulsion. In the basic process, a pressure-sensitive adhesive formulation comprised of at least one ester of acrylic or methacrylic acid is polymerized in the presence of water and an emulsifier thereby forming an emulsion polymerized pressure-sensitive adhesive. The improvement resides in effecting the polymerization of the pressure-sensitive adhesive formulation comprised of at least one ester of acrylic or methacrylic acid in the presence of from 5 to 30 percent by weight of a styrene containing polymer containing at least 80 percent by weight styrene.
This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety evaluation of the acrylic acid, sodium salt, co-polymer with acrylic acid, methyl ester, methacrylic acid, 2 hydroxypropylester, and acrylic acid cross-linked (CAS No. 117675-55-5, FCM Substance No 1022), to be used as liquid absorber in the form of fibres in absorbent pads for the packaging of fresh or frozen meat, poultry, and fish as well as fresh fruits and vegetables. The Panel considered that migration is not expected when the absorption capacity of the pads is not exceeded. Therefore no exposure from the consumption of the packed food is expected. The Panel also considered that none of these starting substances and the cross-linked polymer gives rise to concern for genotoxicity. Therefore the CEF Panel concluded that the use of the substance acrylic acid, sodium salt, co-polymer with acrylic acid, methyl ester, methacrylic acid, 2 hydroxypropylester, and ...
Epigenetic" implies changes in regulatory states of genes or genomic DNA without changes in DNA sequence. The archetypical epigenetic modification in eukaryotic genomes is the addition of a methyl group to the fifth carbon of cytosine to produce 5-methylcytosine (5meC) [1, 2], reviewed in [3]. Cytosine DNA methylation is an epigenetic modification that is shared by many eukaryotic organisms. Along with various other epigenetic modifications such as methylation, phosphorylation and acetylation of histone amino acids, cytosine methylation is an important regulator of biological processes including transposon silencing, heterochromatin organization, genomic imprinting, and gene expression.. The distribution of cytosine methylation is highly variable within plant genomes [4]. This overall methylation pattern, which is conserved among diverse plant taxa, is often described as "mosaic," as it consists of interspersed methylated and unmethylated regions [5, 6]. The patterns of 5meC, mechanisms for de ...
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.
Angelman syndrome (AS) is characterized by mental retardation, absence of speech, seizures and motor dysfunction. AS is caused by maternal deletions for chromosome 15q11-q13, paternal uniparental disomy (UPD), imprinting defects or loss-of-function mutations in the UBE3A locus which encodes E6-AP ubiquitin-protein ligase. The UBE3A gene is imprinted with paternal silencing in human brain and similar silencing of the Ube3a locus in Purkinje cells and hippocampal neurons in the mouse. We have sequenced the major coding exons for UBE3A in 56 index patients with a clinical diagnosis of AS and a normal DNA methylation pattern. The analysis identified disease-causing mutations in 17 of 56 patients (30%) including 13 truncating mutations, two missense mutations, one single amino acid deletion and one stop codon mutation predicting an elongated protein. Mutations were identified in six of eight families (75%) with more than one affected case, and in 11 of 47 isolated cases (23%); no mutation was found ...
Charles G. Morris: Charles G. Morris received his B.A. from Yale University and his M.A. and Ph.D. in psychology from the University of Illinois. He joined the University of Michigan in 1965 as Assistant Professor of Psychology and was promoted to Associate Professor in 1971 and Professor in 1987. He served as Associate Dean in the College of Literature, Science and the Arts and as Associate Chair of the Department of Psychology. Upon his retirement in 2002, he was appointed Emeritus Professor. He is a Fellow of the American Psychological Association and the American Psychological Society. He is the author of more than two dozen books, more than a dozen articles, and more than thirty papers and presentations. His books include "Psychology: An Introduction," "Understanding Psychology," "Basic Psychology," "Psychology: Concepts and Applications," and "Contemporary Psychology and Effective Behavior," His early research centered on leadership, group interaction, and group problem solving. More ...
This paper reports on the childs perception of parental involvement and the effect it has on grades in mathematics, science, social studies, and language arts. The study specifically involved the relationship between the value the children perceive the parents place on education and the value the children themselves place on education, the relationship between the childs perception of parents helping the child with homework in the elementary and middle school years and the amount of time the child spends on homework in high school, and the relationship between the childrens perception of expectations the parents have for him/her and the expectations the children place on themselves. Questionnaires were given to 102 9th graders. The data was analyzed using correlation analyses and a one way analysis of variance (ANOVA). Implications for parents and educators are also noted ...
Russ noted that African American and Native American communities have been especially hard-hit by menthol cigarettes.. On Friday, Courtney Clark, a public health and psychology student at the University of Minnesota Duluth, took part in an American Lung Association press conference designed to draw public attention to the issue.. In a statement, Clark said: "Menthol has been marketed to the African-American community for over 50 years, and as a result, nearly 90 percent of African-American smokers use menthol products. We can sit idly by and hope this malicious targeting by Big Tobacco ends, or we can take initiative to make sure that kids dont have easy access to these deadly products.". Russ said she shares the concern that minority populations have been subjected to targeted menthol cigarette marketing campaigns, but she stressed the proposed ordinance is not intended to be a paternalistic measure. Russ noted that both the Duluth Human Rights Commission and the Indigenous Commission have ...
Beckwith-Wiedemann syndromeDefinitionBeckwith-Wiedemann syndrome (BWS) refers to a disorder of overgrowth. This condition is usually characterized by large body size (macrosomia), large tongue (macroglossia), enlarged internal organs (visceromegaly), the presence of an abdominal wall defect (umbilical hernia or omphalocele ), and low blood sugar in the newborn period (neonatal hypoglycemia). Source for information on Beckwith-Wiedemann Syndrome: Gale Encyclopedia of Genetic Disorders dictionary.
Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and SNP data from prostate cancer genome-wide association studies (GWAS), researchers at the Princess Margaret Cancer Center identified 45 candidate lncRNAs associated with risk to prostate cancer. They further evaluated the mechanism underlying the top hit, PCAT1, and found that a risk-associated variant at rs7463708 increases binding of ONECUT2, a novel androgen receptor (AR)-interacting transcription factor, at a distal enhancer that loops to the PCAT1 promoter, resulting in upregulation of PCAT1 upon prolonged androgen treatment. In addition, PCAT1 interacts with AR and LSD1 and is required for their recruitment to the enhancers of GNMT and DHCR24, two androgen late-response genes implicated in prostate cancer development and progression. PCAT1 promotes prostate cancer cell proliferation and tumor growth in vitro and in ...