Whilst we welcome the acknowledgement by the Foreign Minister that Amnesty International are regarded as a credible global organisation, his assertion that we will be able to conduct activities freely is a bold claim in light of the fact that both the Director and the Chair of Amnesty International Turkey are languishing behind bars alongside seven other human rights activists.. "The absurd case against Idil Eser is not based on any nefarious activities but instead rests entirely upon the legitimate work of Amnesty International. If this work is criminalised, it is hard to see how the organisation - or indeed the wider human rights movement in Turkey - can continue to function.. "Equally, the unfounded allegation that has landed Taner Kiliç in jail - that he downloaded and used Bylock on his phone - is false and we will show it. The vital work done by Amnesty International and the people who undertake that work cannot be separated. They are indivisible and we will fight to secure their ...
DESCRIPTION: Recent phase II clinical studies demonstrate that an antibody targeting proportion convertase subtilisin/kexin type 9 (PCSK9)-a target for the treatment of hypercholesterolemia and coronary heart disease-successfully and safely decreases amounts of low-density lipoprotein-cholesterol (LDL) in patients with hypercholesterolaemia undertaking statin treatment.1,2 However, to date, there are no reports of small molecules or peptides achieving the same effect. This application offers a mature fragment-based design methodology to create novel small molecule PCSK9 inhibitors that achieve a targeted activity in surface plasmon resonance direct and competition assays as well as in a functional assay, LDL uptake in hepatocyte cells. Such an alternativeapproach to this problem is compelling because high-throughput screening campaigns at large pharmaceutical companies have generally not yielded progressable hits for PCSK9. Using our recently described hot-spot mapping technique,3,6 we found ...
An immobilized immunoadsorbent for use in immunoassay and radioimmunoassay procedures includes, in a preferred form, a mass of superficially porous refractory particles having a water insoluble polymer, such as dextran, bonded thereto. The polymer in turn has bonded to it, by covalent bonds, antibodies capable of binding a specific antigen thereto and stoichiometrically releasing the bound antigen by the use of a rinsing solution which does not adversely affect the binding of the antibody to the polymer. Preferably, each of the porous particles includes an impervious core which has joined thereto sufficient layers of microparticles to form an outer porous coating on the core. Methods of forming such an immunoadsorbent and for using the same and structure for supporting the same are also disclosed.
A patient with a metastatic colon carcinoma was treated by immunoadsorption (IA) therapy using heat-killed, formalin-stabilized protein A-containing Staphylococcus aureus Cowan I as the immunoadsorbent. The patient experienced both subjective and objective positive clinical response without undue morbidity. The patients response correlated well with laboratory findings of decreased concentrations of carcinoembryonic antigen (CEA), immunoglobulin G (IgG), immune complexes (IC) and histopathologic data. The patient underwent surgery following 15 IA treatments; she lived for eighteen months, post-treatment.
Heart failure due to coronary heart disease (CHD) remains one of the most frequent causes of death. Left-ventricular ejection fraction , 30% is associated with a 5-year mortality , 70%. Therefore, new strategies and therapies towards treatment of heart failure are needed.. Heart failure due to left ventricular dysfunction can develop in CHD beyond the area of myocardial infarction. Some of these patients develop myocardial autoantibodies, which have been shown to exert a negative inotropic effect. Their elimination by immunoadsorption has been shown to improve left ventricular function in dilatative cardiomyopathy. Immunoglobulins are substituted to minimize infection risk at a level, which has been shown not to effect cardiac function. This intervention might also ameliorate cardiac function in patients with heart failure due to other origins. This study therefore aims to evaluate the effect of immunoadsorption with subsequent immunoglobulin substitution. ...
The study covers current and future market trends, drivers, challenges, and opportunities in US therapeutic apheresis market. It breaks down the market into hematology and oncology, neurology, rheumatology, and other therapeutic areas. Therapeutic apheresis has become an essential element of the blood and blood components industry value chain. Hospitals are the primary users of apheresis equipment and solutions; other users include blood banks and dialysis centers. End users include therapeutic apheresis nurses, referring physicians, hematologists, oncologists, rheumatologists, neurologists, nephrologists, cardiologists, and lipidologists. The study covers standard plasmapheresis or plasma exchange, extracorporeal immunoadsorption, plateletpheresis, red cell exchange, leukapheresis, and lipidpheresis. The two broad product categories are devices and disposables. The study discusses key trends that are expected to impact the market, including more applications across different therapeutics segments and
The study covers current and future market trends, drivers, challenges, and opportunities in US therapeutic apheresis market. It breaks down the market into hematology and oncology, neurology, rheumatology, and other therapeutic areas. Therapeutic apheresis has become an essential element of the blood and blood components industry value chain. Hospitals are the primary users of apheresis equipment and solutions; other users include blood banks and dialysis centers. End users include therapeutic apheresis nurses, referring physicians, hematologists, oncologists, rheumatologists, neurologists, nephrologists, cardiologists, and lipidologists. The study covers standard plasmapheresis or plasma exchange, extracorporeal immunoadsorption, plateletpheresis, red cell exchange, leukapheresis, and lipidpheresis. The two broad product categories are devices and disposables. The study discusses key trends that are expected to impact the market, including more applications across different therapeutics segments and
The human P450III family has been shown to be composed of at least four members, P450IIIA3 (HLp), P450IIIA4 (P450NF), P450IIIA5 (HLp3), and P450IIIA6 (HLp2). Due to the lack of probes that specifically recognize the individual members of this family, little is known about their relative expression. We prepared a form-specific antibody to P450IIIA5 by immunoabsorption of anti-P450IIIA5 IgG against Sepharose 4B upon which microsomes that did not contain P450IIIA5 or purified P450IIIA3 had been bound. Immunoblot analyses demonstrated that P450IIIA5 was expressed at detectable levels in only 19 of 66 (29%) human livers. The expression of P450IIIA5 was not influenced by the gender or medical history of the patients. When the expression of P450IIIA5 in different age groups was examined, it was observed that P450IIIA5 was detected in a statistically significantly higher percentage of children and adolescents (19 years old and under), as compared with the remaining population (8 of 17, 47%, versus 11 of ...
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Immunoaffinity Column Rack [CR1] - Intended use: R-Biopharm Rhône has designed a simple and easy to use racking system for performing immunoaffinity column analysis. Inserts are also available for the rack.General information: With its solid, chemical resistant structure, RBRs variable position immunaffinity column rack gives users a stable foundation to handle multiple analysis. Holding up
Bacteria reactive to plaque toxin neutralizing monoclonal antibodies are related to the severity of gingivitis at the sampled site is an eagle-i resource of type Journal article at eagle-i Network Shared Resource Repository.
Barz D, Friedrich S, Schuller A, Rummler S.. Keywords: Antibody against angiotensin II-R1; Donor-specific-antibody; Eluate; Graft survival; Immunoadsorption Abstract. BACKGROUND:. The influence of ATR-1-autoantibodies on antibody mediated rejection (AMR) is still discussed controversially. Here we demonstrate some aspects as to diagnostics, treatment, clinical relevance and graft outcome.. METHODS:. A total of 27 transplant recipients (6 heart, 16 kidney, 3 lung and 2 multi-organ) suffering from AMR and a control group without transplant (8 pre-Tx, 1 pregnancy and 16 autoimmune and haematological diseases) were studied. In total, 290 IA eluates and the corresponding patient serum samples before and after immunoadsorption (IA) were analysed.. RESULTS:. ATR-1-and ETR-auto-antibodies (aAB) were found only in 4.5% of sera previous to IA treatment by using ELISA, but could be detected in 42% of IA eluates. AB with very high titres (,1:8 to 1:256) in the eluate were found more frequently in heart than ...
Extracorporeal blood correction (hemosorption, immunoadsorption, plasmapheresis) in Henoch-Schonlein purpura (costs for program #179319) ✔ DKD HELIOS Clinic Wiesbaden ✔ Department of Bone Marrow Transplant ✔ BookingHealth.com
Extracorporeal blood correction (hemosorption, immunoadsorption, plasmapheresis) in Henoch-Schonlein purpura (costs for program #144113) ✔ Academic Hospital Harlaching ✔ Department of Hematology, Oncology and Palliative Medicine ✔ BookingHealth.com
Importance of herbal medicines have recently increased owing to rising interest in their health benefits. However, medicinal plant extracts are complex mixtures of phytochemicals that act synergistically or additively on specific and/or multiple molecular and cellular targets. Thus, it is difficult to examine the actual pharmacological roles of active compounds in plant extracts. This review describes a new strategy for isolating target compounds from plant extracts using immunoaffinity columns coupled with monoclonal antibodies (mAbs) against natural compounds. Through one-step purification using mAb-coupled immunoaffinity columns, we succeeded in preparing a knockout (KO) extract, which contains all components except the target compound. Furthermore, we investigated the pharmacological effects of the KO extract to reveal the actual effects of a bioactive compound in the crude extract. This approach may help determine the potential function of target compounds in herbal medicines.
Monoclonal antibodies are a rapidly emerging group of drugs with the potential for treating diseases from arthritis to cancer. Now, a new technique called magnifection is set to drastically reduce the time and expense needed to make these molecules, ensuring that enough can be made to treat patients at a reasonable cost. Imagine reading the…
TY - JOUR. T1 - Partial purification of presynaptic plasma membrane by immunoadsorption. AU - Miljanich, G. P.. AU - Brasier, A. R.. AU - Kelly, R. B.. PY - 1982. Y1 - 1982. N2 - During transmitter release, synaptic vesicle membrane is specifically inserted into the nerve terminal plasma membrane only at specialized sites or active zones. In an attempt to obtain a membrane fraction enriched in active zones, we have utilized the electric organ of the marine ray. From this organ, a fraction enriched in nerve terminals (synaptosomes) was prepared by conventional means. These synaptosomes were bound to microscopic beads by an antiserum to purified electric organ synaptic vesicles (anti-SV). The success of this immunoadsorption procedure was demonstrated by increased specific activities of bead-bound nerve terminal cytoplasmic markers and decreased specific activities of markers for contaminating membranes. To obtain a presynaptic plasma membrane (PSPM) fraction, we lysed the bead-bound ...
Monoclonal antibodies (Mabs), produced in the laboratory, are derived from the antibodies that the human body produces in the natural course to fight intruders that threaten health. The discovery of these antibodies have radically transformed our understanding of how diseases progress, and how they can be more quickly, accurately, and cheaply diagnosed, and thus substantially expanded the horizons of treatment for more than 50 major ailments. The importance of Mabs can be estimated from the fact that today a majority of the most commercially-successful drugs are Mab-derived, and Mab-drugs are projected to clock sales of US$125 billion annually by 2020.. Mabs in Cancer Treatment Cancer is unarguably one of the fields where monoclonal antibodies have had the strongest impact. The biggest advantage of Mabs is that they are able to avoid the healthy cells while specifically targeting the cancer cells. This translates to the patient experiencing fewer side effects than conventional radiotherapy or ...
Specificity: hormone treated animals - Binding capacity determined by RIA : approx. 60 ng of clenbuterol per 400 l of resin column ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Objective: After detection of immunological abnormalities in dilated cardiomyopathy (DCM), including autoimmune reactivity against myocytes, attention has been focused on autoimmune mechanisms as potential key elements in DCM pathogenesis. DCM often appeared related to elevated autoantibody (AAB) levels against cardiac proteins including β1-adrenoreceptors. IgG reduction by unselective immunoadsorption (IA) i.e. extracorporeal IgG adsorption to levels at which β1-AABs become nearly undetectable, can be an efficient treatment. Nevertheless, there is controversy on whether β1-AAB removal by IA is indeed the major cause for cardiac improvement. We compared the results of unspecific IA and selective β1-AAB removal.. Methods: In 8/2000-1/2005 DCM patients with LVEF ≤ 30%; and evidence of serum β1-AABs underwent random selection for either unspecific or specific IA which was performed on 5 consecutive days with daily β1-AAB measurements. For unspecific (unselective) IA we used columns ...
Monoclonal antibodies are successful biologics in treating a variety of diseases, including the prevention or treatment of viral infections. CL184 is a 1:1 combination of two human monoclonal IgG1 antibodies (CR57 and ...
Monoclonal antibodies are substances produced in a lab that attach to certain proteins in the body (like a key in a lock). The antibodies can boost your bodys natural defenses against disease or can be used to kill cancer cells or slow the progress of a disease. Monoclonal antibodies are given through an intravenous...
Hoffmann, Frank; Kraft, Andrea; Heigl, Franz; Mauch, Erich; Koehler, Jürgen; Harms, Lutz; Kuempfel, Tania; Koehler, Wolfgang; Ehrlich, Sven; Bayas, Antonios; Weinmann-Menke, Julia; Beuker, Carolin; Henn, Karl-Heinz; Ayzenberg, Ilya; Ellrichmann, Gisa; Hellwig, Kerstin; Klingel, Reinhard; Fassbender, Cordula Marie; Fritz, Harald; Slowinski, Torsten; Weihprecht, Horst; Brand, Marcus; Stiegler, Thomas; Galle, Jan; Schimrigk, Sebastian (2018): Tryptophan immunoadsorption during pregnancy and breastfeeding in patients with acute relapse of multiple sclerosis and neuromyelitis optica. In: Therapeutic Advances in Neurological Disorders, Vol. 11 [PDF, 241kB] ...