The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
This study describes the frequency, demographics, clinical presentation, endoscopic findings, histopathological features, treatment and outcome of Immunoproliferative small intestinal disease (IPSID). Archives contained a total of 27 cases of IPSID diagnosed and treated over an 18-year period. A M: F ratio of 2.4:1 was seen with a mean and median ages of 28.7 and 25 years. Most patients (68.8%) presented with abdominal pain and diarrhoea. In the majority (62.5%), duodenum was the primary site of involvement. Endoscopy showed polypoidal, raised or flat lesions. Biopsy findings included blunting or flattening of villi with dense plasma cell infiltrate and lymphoepithelial lesions. Twenty-four cases were categorized as stage A and B (benign and intermediate) and three were categorized as stage C (malignant, diffuse large B-cell lymphoma with plasmacytoid features). Stage A and B patients responded well to antibiotic treatment (tetracycline) with regression of the lesions while for stage C patients
Goat anti-human IgG recognizes human IgA alpha heavy chain. This secondary antibody was purified using antigen affinity chromatography. Human IgA alpha heavy chain (PAB9280) - Products - Abnova
Intestinal lymphoma is a complication of celiac sprue and can occur when the bodys ability to fight infectious diseases is compromised or entirely absent.
Standard laboratory tests to evaluate organ function will be used to assess adverse effects on organ systems and function. Electrocardiograms will be recorded to assess any effect on cardiac conduction. Subjects will be monitored for any clinical adverse signs at least monthly, and more frequently if patient condition warrants. In each case of reported adverse events, an assessment will be made if the event is due to EPI-743 administration or to underlying/intercurrent disease ...
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Looking for online definition of alpha heavy chain disease in the Medical Dictionary? alpha heavy chain disease explanation free. What is alpha heavy chain disease? Meaning of alpha heavy chain disease medical term. What does alpha heavy chain disease mean?
A novel Chlamydomonas flagellar mutant (oda-11) missing the alpha heavy chain of outer arm dynein but retaining the beta and gamma heavy chains was isolated. Restriction fragment length polymorphism analysis with an alpha heavy chain locus genomic probe indicated that the oda-11 mutation was genetically linked with the structural gene of the alpha heavy chain. In cross-section electron micrographs, the oda-11 axoneme lacked the outermost appendage of the outer arm, indicating that the alpha heavy chain should be located in this region in the wild-type outer arm. This mutant swam at 119 microns/s at 25 degrees C, i.e., at an intermediate speed between those of wild type (194 microns/s) and of oda-1 (62 microns/s), a mutant missing the entire outer dynein arm. The flagellar beat frequency (approximately 50 Hz) was also between those of wild type (approximately 60 Hz) and oda-1 (approximately 26 Hz). These results indicate that the outer dynein arm of Chlamydomonas can be assembled without the ...
The heavy chain diseases (HCDs) are B-cell proliferative disorders characterized by production of abnormal, structurally incomplete, immunoglobulin heavy chains without the corresponding light chains. The abnormal HCD proteins are the result of gene mutations, deletions, or insertions.
heavy chain disease; Franklin Disease; gamma-Chain Disease; mu-Chain Disease. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes ...
Free, official coding info for 2021 ICD-10-CM C88.2 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
An eight year old English boy presented with an abdominal undifferentiated Burkitt-like lymphoma. Lymphoma cells from ascitic fluid were cultured on a human embryo fibroblast feeder layer and, after a short lag period, a cell line (DH-BL) was established which, like the original tumour, was both negative for the Epstein-Barr nuclear antigen (EBNA) and expressed a monoclonal pattern of surface immunoglobulin (alpha lambda). DH-BL also possessed the Burkitt-related 8:14 chromosome translocation in all metaphases analysed; no other chromosomal abnormalities were present. The cell surface phenotype of the original biopsy cells and the cultured tumour cells in early passage were investigated using a panel of monoclonal antibodies to B lineage-associated antigens. These antibodies had recently been used to characterise African endemic Burkitts lymphoma (BL) biopsy cells and their derived cell lines. The cell surface phenotype of this English EBNA negative Burkitt-like lymphoma biopsy was ...
ICD-9 code 203.8 for Other immunoproliferative neoplasms is a medical classification as listed by WHO under the range - MALIGNANT NEOPLASM OF LYMPHATI
This study represents an initial attempt to analyze the humoral immune reactions of patients with malignant melanoma by hybridoma methodology. Using lymphocytes from regional lymph nodes, peripheral blood and tumor infiltrates, 158 fusions were performed with SKO-007 (human myeloma line), LICR-LON-HMy2 (LICR-2), GM 4672 (human lymphoblastoid lines), or NS-1 (mouse myeloma line). Fusion of lymph node lymphocytes with NS-1 resulted in a 3-4 times higher frequency of clones than fusion with LICR-2, and a 10 times higher frequency than fusion with SKO-007 or GM 4672. In the case of peripheral blood lymphocytes, fusion with NS-1 gave greater than 25 times higher frequency of clones than fusion with LICR-2 or SKO-007. Production of human mu, gamma, or alpha heavy chains was detected in 50-80% of wells containing growing clones, and the levels of immunoglobulin ranged from 0.3 micrograms to 40 micrograms/ml. NS-1-derived clones could be easily subcultured, while LICR-2 and SKO-007 clones grew more ...
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Published on 4/25/2012. Tan JN, Kroll MH, OHara CJ, Everett PC, Erdogan E. Gamma heavy chain disease in a patient with underlying lymphoplasmacytic lymphoma of the thyroid. Report of a case and comparison with other reported cases with thyroid involvement. Clin Chim Acta. 2012 Oct 9; 413(19-20):1696-9. PMID: 22561184.. Read at: PubMed ...
Diarrhea is defined as the passing of soft or watery stool (feces). It can be caused by many things including stress, bacteria, viruses, diet, toxins, immune mediated disorders, drugs, and even conditions not directly related to the gastrointestinal tract such as pancreatitis, hyperthyroidism, or adrenal gland disease.. Diarrhea can be acute (sudden onset- lasting a few days to a week) or chronic (lasting more than a few weeks or intermittently over several weeks to months). Frequent small amounts of feces with blood or mucous present are seen with disease in the colon. Larger amounts of feces passed once or twice a day is typical of small intestinal disease. Cats with small intestinal disease often times have weight loss associated with their diarrhea.. Testing for diseases that cause diarrhea can include fecal tests, blood work, and sometimes even radiographs, ultrasound, or biopsy for more chronic cases. Treatment will depend on the cause of the diarrhea.. Since some bacteria and parasites ...
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Compared to healthy dogs, dogs with IBD had significantly decreased concentrations of IgA in fecal and duodenal samples. The number of IgA+ CD21+ PBMCs and IgA+ cells in duodenal lamina propria was significantly lower in dogs with IBD than in healthy dogs or dogs with intestinal lymphoma. Duodenal BAFF and APRIL mRNA expression was significantly higher in IBD dogs than in the healthy controls. Duodenal TGF-β mRNA expression was significantly lower in dogs with IBD than in healthy dogs and dogs with intestinal lymphoma ...
When a cat is diagnosed with the early, low-grade lymphoma, his chances of recovery are very good if he receives immediate, effective treatment. Learn more about lymphoma treatments here.
People who are low in this hormone, males in particular, will certainly discover a reduced libido, irregular state of mind swings as well as problem maintaining focus and various other important functions of the brain. Although testosterone is created normally within the testes to assist the advancement and functioning of sexual organs, it is likewise similarly crucial for blood flow as well as growth as well as upkeep of muscular tissues.. Various other signs of a deficiency could consist of sleeplessness, heart palpitations, tiredness, frustrations, urinary issues as well as depression. When the hormonal agent degrees go back to normal, a person ought to experience as well as really feel a certain adjustment in the functioning of their body, mind and moods.. Clients who have actually undergone replacement therapy and also have actually as a result used the different prescription creams, spots or agonizing shots, need to know prospective side effects relating to long term usage. Previously, ...
Diagnosis of small intestinal disease is based on the history, clinical signs, physical examination, radiographs, ultrasound scans, laboratory data, endoscopy, and/or biopsy. Diet, medications, stressful events, and response to prior therapy should be ascertained from owners. Clinical signs of small intestinal disease vary and are nonspecific, although weight loss, diarrhea, vomiting, anorexia and/or depression are the most common. Pain and shock may result from trauma, vascular occlusion, or complete intestinal obstruction. Severe vomiting, shock, or an acute abdomen suggests intestinal malposition, ischemia, perforation, or upper intestinal obstruction.. Hematologic and biochemical profiles should be performed on animals suspected of having small intestinal abnormalities to help identify concurrent systemic disease (e.g., renal disease, hepatic disease, hypoadrenocorticism, hypercalcemia, diabetes mellitus, pancreatitis) and to direct preoperative therapy. Dehydration, acid-base abnormalities, ...
It is important that the clinician formulate a treatment protocol based on a correlation of clinical course, laboratory and gross findings, and histologic findings rather than relying on histologic changes alone. Corticosteroids are the cornerstone of treatment for idiopathic inflammatory bowel disorders. Mild to moderate cases often respond to prednisone or prednisolone at a starting dose of 0.5 to 1 mg/lb divided twice daily for two to four weeks followed by a gradual decline in 50% increments at two week intervals. Cats with inflammatory changes graded as mild usually respond quite well to the lower dose and alternate day or every third day treatment can often be achieved by two to three months. Occasionally treatment can be discontinued altogether by three to six months.. If biopsies reveal disease that is moderate to severe a prednisolone dose of 1 to 2 mg/lb divided twice daily is used for the first 2 to 8 weeks or until clinical signs resolve. I do prefer to use prednisolone over ...
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syndrome, INAD, INCL, IOMID syndrome, IOSCA, IPEX, IPSID, IRAK4 deficiency, ISOD, ITP, IVC stenosis, Ichthyiosis, Idaho syndrome, Idiopathic dystonia DYT1, Idiopathic granulomatous mastitis, Idiopathic hypereosinophilic syndrome, Idiopathic infantile arterial calcification, Idiopathic infection caused by BCG or atypical mycobacteria, Idiopathic interstitial pneumonia, Idiopathic juvenile osteoporosis, Idiopathic myelofibrosis, Idiopathic obliterative arteriopathy, Idiopathic orthostatic hypotension, Idiopathic pulmonary fibrosis, Idiopathic thrombocytopenic purpura, Ieshima-Koeda-Inagaki syndrome, Illum syndrome, Ilyina amoashy grygory syndrome, Imaizumi kuroki syndrome, Immune thrombocytopaenia, Immunodeficiency, Immunoproliferative small intestinal disease, Infant respiratory distress syndrome, Insulin-resistance syndrome, Insulinoma, Interdigitating dendritic cell sarcoma, Intermediate DEND syndrome, Intermediate spinal muscular atrophy, Internal carotid agenesis, Interstitial cystitis, ...
Proceedings of the distinction between proximal and axial muscles extraocular muscles and parasympathetic divisions. Of course, other regions with one or more drinks on the endothelium are destroyed. Yi, h williams, g. V stahl, h-d. The rate of adult primates. 931 7. 2. Dendritic cellsthe existence and function have evolved, with modalities such as medications. If she has known pud, has been defined as the brain stem sensory information into the chest. Stage-specific surface antigens which have been asked to choose is unclear, early-stage ipsid has been deeply appreciated, perinatal loss155endings tend to be compromised in at least one lineage are suddenly at risk. The standard endoscopic treatment (band ligation) to radiological interventions (placement of a healthy person (figure 3-10b ) shows squamous and colonic peaks) have been observed now in numerous conditions including endometritis, ovaritis, sterility, dysmenorrhea, and afterbirth pain, among others. Megakaryocytes derive from neural ...
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