passive vaccination News: Latest and Breaking News on passive vaccination. Explore passive vaccination profile at Times of India for photos, videos and latest news of passive vaccination. Also find news, photos and videos on passive vaccination
Passive administration of antibodies to 80kDa HSA and its peptides NT, 1, 2 and 4 resulted in agglutination of epididymal spermatozoa with loss of motility but had no effect on sperm count or weights of the reproductive organs. These animals failed to impregnate normal female rats. Passive administration of these antibodies to female rats also resulted in infertility. The presence of antibodies was detected by enzyme-linked immunosorbent assay in uterine secretions of animals treated with antipeptide antibody. The presence of agglutinated spermatozoa was observed in the post-coital vaginal smears of these animals. The immunized females were found to be ovulating normally and the number of corpora lutea were unaltered. Of the four antipeptide antibodies studied, antibodies to peptides NT and 1 were most effective in inhibiting fertility both in male as well as female rats. Hence, the antifertility studies were further confirmed by passive administration of 10 and 40 μg of purified ...
1, 2 CDC. Summary of notifiable diseases, United States, 1997. MMWR 1998; 46:1-87..CDC. Prevention of hepatitis A through active and passive immunization. MMWR 1999;48 (No. RR-12): 5.. 3 Jacobs J. "The cost effectiveness of childhood hepatitis A vaccination." Presentation at American Liver Foundation Meeting "Strategic Directions for Reducing Hepatitis A in High Endemic States", St Louis, MO, June 10, 2000.. 4 CDC. Prevention of hepatitis A through active and passive immunization. MMWR 1999; 48 (No. RR-12): 1. 5 de Vincent-Hayes N. Hepatitis. Current Health 1995; 22(4): 20.. 6 CDC. Summary of notifiable diseases, United States, 1997. MMWR 1998; 46:1-87.. 7 CDC. Prevention of hepatitis A through active and passive immunization. MMWR 1999; 48(No. RR-12): 5. 8 CDC. Prevention of hepatitis A through active and passive immunization. MMWR 1999; 48(No. RR-12): 4. 9 Hutin YJ, et al. A multistate, food borne outbreak of hepatitis A. N Engl J Med 1999; 340(8): 595-602.. 10 CDC. Prevention of hepatitis A ...
Pertussis, or whooping cough, is a disease that claims the lives of 195,000 children across the globe annually. Jennifer Maynard, a chemical engineer at the University of Texas at Austin, is working on a better way to treat it. Her team is on the cusp of a therapeutic injection to treat the symptoms of pertussis and the painful coughing fits that come with the illness. Maynards passive immunization techniques gives babies who??ve had exposure to pertussis ??instant immunity?%9D using a mixture of two antibodies. The first binds to the whooping cough toxin, preventing it from attaching to healthy cells. The second stops the toxin from reaching its target within a healthy cell. ??It gives this one-two punch to deal with the toxin,?%9D says Maynard. The therapeutic can also help babies who??ve contracted the disease by alleviating their symptoms, which are caused by toxin, in conjunction with antibiotics that eliminate the bacteria that causes the illness.
Of four potential passive immunotherapies, scientists heading the Alzheimers Prevention Initiative chose the relative newcomer crenezumab for an upcoming secondary prevention trial in asymptomatic people carrying familial Alzheimers disease mutations (see ARF related news story). The first published data on the anti-Aβ antibody seems to justify that decision. In the July 11 Journal of Neuroscience, scientists led by Ryan Watts at Genentech, San Francisco, California, report that the antibody binds all forms of Aβ, including toxic oligomers. Watts, together with colleagues at Genentech and AC Immune, Lausanne, Switzerland, explains how the unique antibody backbone stimulates microglia just enough to clear Aβ, but not so much to induce inflammatory responses, making it safer at high doses than other passive immunotherapies. The paper also outlines Phase 1 clinical trial safety results. Some of these data have been presented previously at conferences.. I had been a little skeptical about the ...
A research team at BYU-Harvard-Stanford has identified a molecule that is key to mothers ability to pass along immunity to intestinal infections to their babies through breast milk.
This study has broader implications beyond simply being another preexposure passive transfer experiment using recently developed broad and potent anti-HIV neutralizing mAbs. It reaches the optimistic conclusion that if an immunogen can be identified/designed to elicit the breadth of anti-HIV neutralizing activity possessed by some of the new generation of mAbs, a vaccine containing such an immunogen may only have to generate modest protective titers to prevent the establishment of infection. It should be noted that the challenge virus inoculum size (3-5 AID50) used in this study was selected to ensure that all of the monkeys would be infected after a single IR inoculation. This challenge dose is orders of magnitude higher than that estimated to establish an HIV-1 infection after vaginal exposure in humans (4-8 per 10,000 exposures; Patel et al., 2014). If, in fact, the calculated 50% protective titer of ∼1:100 against a virus challenge of 3-5 AID represents a gross overestimate, then the true ...
Passive immunization involves the transfer of antibodies generated by one person directly to another to provide protection, which is shorter-lived.
Most successful vaccines elicit neutralizing antibodies and this property is a high priority when developing an HIV vaccine. Indeed, passively administered neutralizing antibodies have been shown to protect against HIV challenge in some of the best available animal models. For example, antibodies gi …
Therapeutic antibodies have revolutionised treatment of some cancers and improved prognosis for many patients. Over half of those available are approved for haematological malignancies, but efficaciou
Passive transfer of DENV2 E85-VRP-immune serum or adoptive transfer of DENV2 E85-VRP-immune B cells can increase the viral RNA levels in the liver upon infectio
Liu J, Ghneim K, Sok D, Bosche WJ, Li Y, Chipriano E, Berkemeier B, Oswald K, Borducchi E, Cabral C, Peter L, Brinkman A, Shetty M, Jimenez J, Mondesir J, Lee B, Giglio P, Chandrashekar A, Abbink P, Colantonio A, Gittens C, Baker C, Wagner W, Lewis MG, Li W, Sekaly RP, Lifson JD, Burton DR, Barouch DH. Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus. Science. 2016 09 02; 353(6303):1045-1049 ...
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IVIG Diseases, Intravenous Immunoglobulin Therapy - AmericanOutcomes.com. We treat IVIG diseases. Intravenous immunoglobulin therapy for IVIG diseases.
The precise mechanism by which immunoglobulin therapy suppresses harmful inflammation is likely multifactorial. For example, it has been reported that immunoglobulin therapy can block Fas-mediated cell death.[23] Perhaps a more popular theory is that the immunosuppressive effects of immunoglobulin therapy are mediated through IgGs Fc glycosylation. By binding to receptors on antigen presenting cells, IVIG can increase the expression of the inhibitory Fc receptor, FcgRIIB, and shorten the half-life of auto-reactive antibodies.[24][25][26] The ability of immunoglobulin therapy to suppress pathogenic immune responses by this mechanism is dependent on the presence of a sialylated glycan at position CH2-84.4 of IgG.[24] Specifically, de-sialylated preparations of immunoglobulin lose their therapeutic activity and the anti-inflammatory effects of IVIG can be recapitulated by administration of recombinant sialylated IgG1 Fc.[24] There are several other proposed mechanisms of action and the actual ...
The article by Pfeifer et al. describes the exacerbation of cerebral hemorrhages seen in an aged APP-transgenic model following passive administration of anti-Aβ antibodies directed to amino acids 3-6. This particular transgenic mouse, called APP23, is described by the authors in a previous paper as a spontaneous hemorrhagic stroke mouse model (Winkler et al., 2001). At approximately 19 months of age onward, the mouse exhibits severe cerebral amyloid angiopathy (CAA), which is associated with recurrent hemorrhages as the mice age. Moderate to severe cerebral vascular amyloid also exists in approximately 26 percent of Alzheimers disease patients, as well, though the rate of hemorrhages is less than that seen in the APP23 mouse (approximately five percent of AD cases; see Greenberg et al., 1998).. When the authors gave 21-month-old APP23 mice a monoclonal antibody directed to Aβ3-6 once a week for five months, they saw that the rate of hemorrhages increased about twofold above baseline. The ...
Abstract Myasthenia gravis (MG) with antibodies to muscle‐specific kinase (MuSK) is characterized by fluctuating fatigable weakness. In MuSK MG, involvement of bulbar muscles, neck, and shoulde ...
To study the effect of passive immunotherapy (PIT) over the HIV-viral load and the CD4 T+-cell counts in patients who have failed to respond to three different Highly-Active Antiretroviral Therapy (HAART), and who have at the moment less than 100 CD4+-T cells/ml and a viral load over 20,000 copies/ml ...
TY - CONF. T1 - Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy. AU - Al Lahham, Rabab. AU - Bittar, Alice. AU - Montalbano, Mauro. AU - Carretero Murillo, Mariana. AU - McAllen, Salome. AU - Bhatt, Nemil. AU - Ellsworth, Anna. AU - Kayed, Rakez. PY - 2018/4. Y1 - 2018/4. M3 - Poster. ER - ...
Definition of adoptive immunity. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen, which causes serious debilitating infections in patients with compromised lung function. The mechanism by which P. aeruginosa is cleared from the lung is not fully defined, although our previous studies have established a role for cellular immunity in protection against P. aeruginosa infections. This study aimed to evaluate the role of P. aeruginosa-specific IgG in protection against P. aeruginosa in a rat model of acute pulmonary infection. Immunoaffinity chromatography was used to purify total rat IgG from rat immune serum (rats immunised with P. aeruginosa) and non-immune serum. Untreated recipient rats were injected intravenously with different concentrations of pure IgG prepared from serum of unimmunised rats (non-immune IgG) or from rats immunised intestinally with killed P. aeruginosa (immune IgG) and infected intratracheally with P. aeruginosa 18 h later. The protective capability of the purified IgG against P. aeruginosa ...
Immunoglobulin Therapy can help people with weakened immune systems or other diseases fight off infections. Intravenous immunoglobulin
Passive administration of therapeutic antitumor cytotoxic antibodies likely results in the in vivo generation of immune complexes (Fig. 3), and recent studies have investigated whether such antibodies initiate a vaccinal effect that is characterized by an antitumor cellular immune response. Examples of cytotoxic antibody-induced vaccinal effects from the clinic include patients treated with anti-MUC1 mAbs or anti-HER2/Neu mAbs, who generated MUC1-specific and HER2-specific T-cell responses, respectively (54, 55). Because a single course of treatment with anti-CD20 mAb (rituximab) can result in long-lasting, durable responses, it has been hypothesized that treatment with this mAb may also induce a vaccinal effect in patients with lymphoma (56). In support of this, lymphoma-specific anti-idiotype T-cell responses were detected in some patients treated with anti-CD20 rituximab (57, 58). Anti-CD20 mAb treatment of lymphoma cells in vitro stimulates DC maturation and CD8 T-cell activation (59), and ...
Reinforcing Method for the Protective Capacities of Dispersal and Combat Facilities using Logistic Regression - explosion verification test;finite element analysis;logistic regression;protective capacity reinforcement;dispersal facility;combat facility;
Circovac emulsion and suspension for emulsion for injection for pigs (25 dose). For the passive immunisation of piglets via the colostrum, after active immunisation of sows and gilts.
Maximizing your potential to live well with multiple sclerosis should be the goal. Learning more about MS, including treatment options, allows you to make better decisions that can affect you now and in the future.
PSEUDOID: Identification and evaluation of peptides for active and passive immunization against Pseudomonas aeruginosa (DFG - German Science Foundation). In this project, we try to find surface structures conserved in all strains of Pseudomonas aeroginosa that are useful as vaccine targets and diagnostic biomarkers. We use both bioinformatics and biochemistry methods to identify and characterize relevant surface proteins.. ...
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... Some people think and analyze a lot and act little. Others, however, without so much thought, are more prone to action. The firsts tend to be passive, ...
Passive aggressive behaviour is seriously unfavourable and intolerable. It is always difficult to be around a person who has passive aggression.
Is active recovery more important than passive recovery? Experts say both are important, but it seems active recovery may be king.
Choose Connection for ACP-EP Memory Cables. Buy a ACP-EP Dell Compatible 40GBase-CU QSFP+ to QSFP+ Passive Twinax Direct Attach Cable, 3m and get great service and fast delivery.
Capsule and pneumolysin (PLY) are two major virulence factors of Streptococcus pneumoniae. S. pneumoniae is one of the leading causes of bacterial endophthalmitis. The aim of this study is to determine whether passive immunization with the 23-valent pneumococcal polysaccharide vaccine (Pneumovax® 23; PPSV23) or PLY protects against pneumococcal endophthalmitis. New Zealand white rabbits were passively immunized with antiserum to PLY, PPSV23, a mixture of PPSV23/PLY, or PBS (mock). Vitreous was infected with a clinical strain of S. pneumoniae. In a separate group of experiments, vancomycin was injected 4 hours post-infection (PI) for each passively immunized group. Severity of infection, bacterial recovery, myeloperoxidase (MPO) activity and percent loss of retinal function were determined. Passive immunization with each antiserum significantly lowered clinical severity compared to mock immunization (PPSV23 = 9.19, PPSV23/PLY = 10.45, PLY = 8.71, Mock = 16.83; P = 0.0467). A significantly higher
We have identified and characterized nine antigenic epitopes on the E envelope of Japanese encephalitis virus (JEV) by using mAb. Passive administration of most of the anti-JEV mAb protected mice from i.v. challenge with 1.5 x 10(3) plaque-forming units of JEV, JaGAr-01 strain. Some mAb, which possess high neutralization activity in vitro, showed high protection, and JEV-specific N mAb 503 was found the most protective. Even an injection of 2.5 micrograms/mouse of mAb 503 protected all mice from JEV infection. Furthermore, an injection of about 200 micrograms of mAb 503 on day 5 postinfection protected 82% of the mice, even when JEV was detected in more than 85% of the infected mouse brains. Synergism of protection was observed with mixtures of several mAb directed against different epitopes. Although in a murine macrophage cell line, all of the mAb groups showed antibody-dependent enhancement (ADE) of JEV infectivity in vitro, and only two flavivirus cross-reactive mAb groups showed ADE of ...
Fish, D C.; Gilden, R V.; Bare, R M.; Trimmer, R M.; and Huebner, R J., "Prevention of spontaneous leukemia in akr mice by passive immunization and type specificity of this protection." (1979). Subject Strain Bibliography 1979. 2794 ...
Immunotherapies that block CD47 stimulate macrophage phagocytosis of cancer, and they synergize with anti-CD20 passive immunotherapy in preclinical human models. CD47-blocking therapies are now under investigation in clinical trials for patients with solid and hematologic malignancies. For this presentation, I will describe our work applying these concepts to preclinical models of canine lymphoma. We validated the canine CD47/SIRPα axis as an immunotherapeutic target for canine cancer, and we have identified therapeutic agents that block canine CD47 and stimulate macrophage phagocytosis of canine lymphoma cells. We found that CD47-blocking therapies could enhance the efficacy of a speciated anti-canine CD20 antibody that is under development for canine lymphoma. The data will provide justification for testing CD47-blocking therapies in combination with anti-CD20 passive immunotherapy in companion animals. Since canine and human lymphoma bear remarkable similarity and treatment strategies, application
HCMV is the leading infectious cause of mental retardation and deafness in infants with congenital HCMV infection. Primary HCMV infections during pregnancy carry the highest risk of fetal infection and disease. No intervention of proven efficacy is available in case of primary HCMV infection in pregnancy. However, a study published in 2005 (Nigro et al., NEJM 353:1350-62, 2005) reported that in pregnant women with primary HCMV infection treated with HCMV-specific hyperimmune globulin (Cytotect®, Biotest) the risk of transmitting the infection to the fetus was reduced from 40% to 16%. Unfortunately, since the study was conducted with inadequate controls, the actual efficacy of hyperimmune globulin could not be properly assessed.. In the present randomized, double-blind, placebo-controlled, multicenter trial pregnant women with ascertained primary HCMV infection at 4-26 weeks of gestation will be randomized to receive Cytotect® or placebo intravenously within 6 weeks after the presumed onset of ...
Free Online Library: Passive antibody administration (immediate immunity) as a specific defense against biological weapons. (Perspective). by Emerging Infectious Diseases; Health, general Antibodies Physiological aspects Biological weapons Usage Immune response Regulation Immune response regulation
Adoptive immunization of syngeneic, immunosuppressed recipients infected with lymphocytic choriomeningitis (LCM) virus causes fatal neurologic disease within 2 to 4 days of cell transfer, providing that donors are sampled when the in vitro 51Cr release assay shows maximal specific activity of sensitized thymus-derived lymphocytes (T cells). Prior treatment of immune spleen cells with AKR anti-θ ascitic fluid and complement causes total abrogation of this in vivo activity. Fatal neurologic disease is induced only when donor and recipient share at least one set of H-2 antigenic specificities. Parent → F1 and F1 → parent combinations are as effective as syngeneic systems, but mice given allogeneic immune cells survive as long as controls. Differences at the M-locus in H-2 compatible mice do not inhibit effector activity. Homing of transferred lymphocytes to spleen is similar in syngeneic or allogeneic recipients, but only syngeneic immune cells cross the blood-cerebrospinal fluid (CSF) barrier ...
TY - CHAP. T1 - Challenges in designing HIV env immunogens for developing a vaccine. AU - Srivastava, Indresh K.. AU - Holland Cheng, R.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - HIV continues to be a major health problem worldwide; however, the situation is particularly serious in Asian and Sub-Saharan countries. Development of an effective HIV vaccine could help to reduce the severity of the disease and prevent infection. Over the last two decades significant efforts have been made toward inducing potent humoral and cellular immune responses by vaccination; however, it appears that either antibodies or CTL may not be sufficient alone for the induction of sterilizing immunity or long-term control of viral replication. Therefore, it is generally believed that both humoral and cellular responses will be needed for an effective HIV vaccine. It has been shown in passive transfer experiments using broadly neutralizing monoclonal antibodies (mAb) such as b12, 2F5, and 2G12 that these mAbs either alone or ...
HIV hyperimmune globulin: do not confuse with HivIg used as abbreviation for hyperimmune intravenous immunoglobulins if not raised against human immunodeficiency viruses (index as IG IV coord with the appropriate organism or antigen)
OBJECTIVES To assess the safety, tolerance, pharmacokinetics, and virologic and immunologic changes associated with the use of Ugandan HIV hyperimmune globulin (HIVIGLOB) in HIV infected pregnant Ugandan women and their infants. DESIGN A prospective, phase I/II, three-arm dose escalation trial of HIVIGLOB. METHODS HIVIGLOB was prepared from discarded HIV infected units of blood collected from the National Blood Bank in Kampala. From June 1996 to April 1997, 31 HIV positive pregnant women were enrolled with HIVIGLOB infusions given at 37 weeks gestation and within 16 h of birth for infants. The first 10 mother-infant pairs were infused at a dose of 50 mg/kg, followed by 11 pairs at 200 mg/kg, and 10 pairs at 400 mg/kg. Study participants were followed for 30 months. RESULTS Thirty-one women and 29 infants were infused with HIVIGLOB. The infusions were safe and well tolerated by the women and their infants at all doses. There were no significant changes in virologic or immunologic parameters after
Current treatment options for Alzheimers disease (AD) are limited to medications that reduce dementia symptoms. Given the rapidly ageing populations in most areas of the world, new therapeutic interventions for AD are urgently needed. In recent years, a number of drug candidates targeting the amyloid-ss (A ss) peptide have advanced into clinical trials; however, most have failed because of safety issues or lack of efficacy. The A ss peptide is central to the pathogenesis, and immunotherapy against A ss has attracted considerable interest. It offers the possibility to reach the target with highly specific drugs. Active immunization and passive immunization have been the most widely studied approaches to immunotherapy of AD. A favourable aspect of active immunization is the capacity for a small number of vaccinations to generate a prolonged antibody response. A potential disadvantage is the variability in the antibody response across patients. The potential advantages of passive immunotherapy ...
Publishers Accepted Manuscript: Proper accounting of mass transfer resistances in forward osmosis: Improving the accuracy of model predictions of structural parameter ...
Intravenous Immunoglobulin Therapy - Clinical Benefits and Future Prospects (New York: The Parthenon Publishing Group, 1995). ISBN: 1850706484 (hardcover). [medical] ...
These results suggest that a combination of protective antibodies with either the same or different isotypes can produce either an additive or a suppressive effect in passive immunization. This phenomenon may be important in better understanding immunity in this experimental mouse model of malaria.. ...
Immune deficiencies are treated with immunoglobulin therapy or gamma interferon therapy, according to Mayo Clinic. Immunoglobulin therapy involves introducing antibody proteins the immune system...
Lecture 18 Humoral Immune Response. The Antibody Response. Antibody Protection of the Host. Immunologic Memory. Virgin lymphocyte pool . PRIMARY RESPONSE . effector cells . memory cell pool . SECONDARY RESPONSE. effector cells . memory cell pool . Immunologically Naive. Slideshow 158264 by elina
Despite decades of research, respiratory syncytial virus (RSV) remains a highly prevalent childhood pathogen without an approved vaccine.1 There is a marketed prophylactic-Synagis palivizumab-to prevent severe disease caused by RSV in at-risk infants, but the passive immunization provided by the antibody does not last from season to season, and its high cost precludes its use in other patient populations.