The term ichthyosis is derived from the Greek word ichthys, which means fish. Ichthyosis is not one disease but a group of disorders in which there is excess accumulation of epidermal cells resulting in the appearance of scales. Severity ranges from mild, asymptomatic to life threatening. There are a large number of types of ichthyosis; most are extremely rare. This condition tends to be worse in the dry, cold winter months and generally improve in the warmer, more humid months of summer. The most common type of ichthyosis is ichthyosis vulgaris which accounts for almost 95% of cases. Apart from ichthyosis vulgaris all other forms of ichthyosis are very rare. Ichthyosis vulgaris affects about 1:250 individuals. Ichthyosis occurs worldwide and affects people of all races. In addition to this there are many more types but only 3 others will be addressed here. They are lamellar, x-linked, and epidermolytic hyperkeratosis forms of ichthyosis. These conditions are inherited and are based on ...
Monogenic disorders, i.e., disorders caused by mutations in a single gene, are rare and clinically heterogeneous conditions. Identification of the genetic cause of monogenic traits can bring new insights into molecular pathways and disease mechanisms. The aims of the present study were to identify the mutant genes in two autosomal recessive skin disorders and to characterize the functions of the mutated genes. In order to identify candidate genes for the two disorders whole-genome SNP analysis, homozygosity mapping and gene sequencing were used.. Autosomal recessive congenital ichthyosis (ARCI) is a group of disorders characterized by extensive scaling and redness of the skin. A subgroup of ARCI patients (n=27) was selected based on specific ultrastructural aberrations in their skin, revealed by electron microscopy. Mutations were identified in the Ichthyin gene in 93% of the selected patients, indicating a strong association between mutant Ichthyin and the specific morphological abnormalities. ...
Autosomal recessive congenital ichthyosis (ARCI) is a rare genetically heterogeneous disorder characterized by hyperkeratosis in addition to dry, scaly skin. There are six genes currently known to be associated with the disease. Exome sequencing data for two affected individuals with ichthyosis from two apparently unrelated consanguineous Pakistani families was analysed. Potential candidate mutations were analysed in additional family members to determine if the putative mutation segregated with disease status. A novel mutation (c.G4676T, p.Gly1559Val) in |i|ABCA12|/i| occurred at a highly conserved residue, segregated with disease status in both families, and was not detected in 143 control chromosomes. Genotyping with microsatellite markers demonstrated a partial common haplotype in the two families, and a common founder mutation could not be excluded. Comparison to previously reported cases was consistent with the hypothesis that severe loss of function |i|ABCA12|/i| mutations are associated with
TY - JOUR. T1 - Novel TGM1 missense mutation p.Arg727Gln in a case of self-healing collodion baby. AU - Tanahashi, Kana. AU - Sugiura, Kazumitsu. AU - Asagoe, Kenji. AU - Aoyama, Yumi. AU - Iwatsuki, Keiji. AU - Akiyama, Masashi. PY - 2014/1/1. Y1 - 2014/1/1. UR - http://www.scopus.com/inward/record.url?scp=84906054613&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84906054613&partnerID=8YFLogxK. U2 - 10.2340/00015555-1765. DO - 10.2340/00015555-1765. M3 - Comment/debate. C2 - 24419105. AN - SCOPUS:84906054613. VL - 94. SP - 589. EP - 590. JO - Acta Dermato-Venereologica. JF - Acta Dermato-Venereologica. SN - 0001-5555. IS - 5. ER - ...
Looking for information on Congenital ichthyosis? Medigest has all you need to know about Congenital ichthyosis - Symptoms and Signs, Causes, Treatments and definition
My apologies in advance if this ends up being a long post, and Im not sure if this is the right section of the forum to post about this (may also post about this in the Support section too) but... I was just wondering if anyone on this forum is familiar with or knows anyone affected by the rare genetic skin disorder Ichthyosis? I was born with Ichthyosis myself (Bullous Ichthyosis - there are many different types), I am expecting my first baby on 1st Aug. and know that there is a 50% chance that my baby or any future children I may have could have the condition too. I dont want to go on about it too much at this stage as it can get a bit complicated, and I dont mind talking about it at all - I have done many talks on the subject for local voluntary organisations etc and for the Ichthyosis Support Group. But I just thought Id ask as it would be nice to contact others in a similar situation as myself. Just in case youre wondering, I have been in touch with the Ichthyosis Support Group ...
Mutations from the gene (and antimicrobial peptide genes and and and mutations S100A8/9 was strongly positive. of varied sizes. Swimwear ichthyosis (BSI) is normally a rare minimal subtype of ARCI where the trunk of your body as opposed to the extremities is principally affected. Self-improving collodion ichthyosis or self-healing collodion baby and acral self-healing collodion baby may also be other minimal subtypes of ARCI where thick scales take place throughout a limited period and regions of your skin in infancy. Mutations in the gene (knockout (mice with homozygous mutations of R142C in the enzyme [7] present a faulty CE and also have disorganized stratum corneum intercellular lipid substances with severe epidermis permeability barrier flaws. The pathology of mutations. The activation of these genes could be a significant autonomous process to bolster the defective epidermis hurdle function in TGM1 deficiencies. Components and Methods Individual specimens The usage of individual specimens ...
TY - JOUR. T1 - A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C. AU - Sunohara, Nobuhiko. AU - Sakuragawa, Norio. AU - Satoyoshi, Eijiro. AU - Tanae, Ayako. AU - Shapiro, Larry J.. PY - 1986/2. Y1 - 1986/2. N2 - We describe a family consisting of 3 affected men with congenital ichthyosis, anosmia, hypogonadism, nystagmus with decreased visual acuity, strabismus, hypopigmentation of the iris, and mirror movements of the hands and feet. Two of them had limitation of ocular movement and unilateral renal agenesis or hypoplasia. The condition appears to be inherited as an X‐linked recessive trait. Clinical, pathological, and biochemical evaluations were compatible with a diagnosis of X‐linked ichthyosis. Steroid sulfatase and arylsulfatase C activities in leukocytes and fibroblasts were markedly diminished in the affected patients. Their hypogonadism was due to decreased luteninizing ...
Hi my name is Cassie Im 32 from Minnesota and I have Ichthyosis Bullosa of Siemens - a variation of EHK. Having Ichthyosis I believe has made me a more self conscious person with a lower self esteem but in other ways it has made me a better person by teaching me first hand how cruel people can be to others with visible differences.. I never thought Id get married and have kids but now Ive been married for almost 15 years and we have 5 children 3 sons and 2 daughters. Four of them inherited the Ichthyosis from me - 2 boys and the 2 girls. ...
Acquired Ichthyosis is a skin condition sometimes described as "fish scale skin." It is a non-hereditary skin condition that makes its appearance for the first time in early adult life.. It is found equally among both genders and all races. Internal diseases or with the use of certain medications may be associated with its development. The conditions severity is different from person to person. What are the symptoms of Acquired Ichthyosis?. Common symptoms of Acquired Ichthyosis include the following: ...
Frontiers in Ichthyosis Research, an international meeting of investigators actively involved in research directly related to ichthyosis, was held in June 2010.
Get information, facts, and pictures about Ichthyosis at Encyclopedia.com. Make research projects and school reports about Ichthyosis easy with credible articles from our FREE, online encyclopedia and dictionary.
A group of cutaneous disorders characterised by increased or aberrant keratinisation, resulting in noninflammatory scaling of the skin. Many different metaphors have been used to describe the appearance and texture of the skin in the various types and stages of ichthyosis, for example alligator, collodion, crocodile, fish and porcupine skin. most ichthyoses are genetically determined, while some may be acquired and develop in association with various systemic diseases or be a prominent feature in certain genetic syndromes. The term is commonly used alone to refer to i. Vulgaris. ...
The outpatient clinic for people with genetic types of skin diseases of our center, and the NIRK associated and the experimental labs that we run in our hospital have been recognized by the national authorities as Reference Center for Ichthyoses and Palmoplantar Keratoses (ReCIP).ReCIP is headed by PD Dr. med. V. Oji. ReCIP and is part of the European Reference Network for rare skin diseases that is supported by the European Commission. Further information is available on the homepage of the university hospital of Münster (UKM ...
Get this from a library! The Ichthyoses : Proceedings of the 2nd Annual Clinically Orientated Symposium of The European Society for Dermatological Research. [R Marks; P J Dykes]
Mutations in connexin26 (Cx26) underlie a range of serious human pathologies. Previously we have shown that Cx26 hemichannels are directly opened by CO2 (Meigh et al., 2013). However the effects of human disease-causing mutations on the CO2 sensitivity of Cx26 are entirely unknown. Here, we report the first connection between the CO2 sensitivity of Cx26 and human pathology, by demonstrating that Cx26 hemichannels with the mutation A88V, linked to Keratitis-Ichthyosis-Deafness syndrome, are both CO2 insensitive and associated with disordered breathing in humans.. ...
QSota Health Tips: Ichthyosis - a disease with a genetic predisposition, characterized by disorder of keratinization of the skin. There are 2 forms of ichthyosis - normal and X
Keratitis-ichthyosis-deafness syndrome is a rare genodermatosis, which has recently been connected with mutations in the connexin-26 gene, GJB2. We present a 15-year-old boy with erythroderma, hyperkeratotic plaques and deafness. Sequencing analysis showed a heterozygous missense mutation D50N (148G,A) in GJB2. The boy has not yet manifested characteristic eye lesions but ...
Ichthyosis is characterized by dryness and scaliness of the skin, and in severe cases it bears a resemblance to the skin of fishes. Ichthyosis was recognized in
The experience of therapeutic education in the management of children with ichthyosis seems important to share while publications are limited. The establishment of a TPE group which was constituted by health professionals seems mandatory because of a the strong sense of rejection expressed by the patients and their families, the impact on quality of life associated with the misunderstanding of the disease and the importance of multidisciplinary monitoring [10, 13].. In our study, we used a step-by-step approach. In brief, TPE group in close partnership with patients and their families identified the required skills for better daily management of the disease. An interview guide for educational diagnosis was created, and learning objectives specific to ichthyosis were determined. This stage of educational diagnosis was essential for better setting the difficulties and the actual resources of patients and their families before going further with the reinforcement program. The areas of need were ...
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6; ARCI6 description, symptoms and related genes. Get the complete information in our medical search engin
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Ichthyosis refers to a relatively uncommon group of skin disorders characterized by the presence of excessive amounts of dry surface scales. It is regarded as a disorder of keratinization or cornification, and it is due to abnormal epidermal differentiation or metabolism.
I live in a world that judges one by outward appearances before taking the time to find out what lies deeper than the skin… very thick skin. I was born with Ichthyosis, a genetic mutation that affects the stratum corneum, a layer of the epidermis. In order to manage the skin, I spend about three hours a day doing a plethora of treatments. I am no different than you though. We are all hit with something challenging in our lifetime, whether it is ongoing or not we must learn to conquer and not let it cripple us. My skin disorder has only made me stronger and more compassionate in this life. It may not be easy, but it is sweet and beautiful when you are not held down by the chains of self-pity, pessimism, and the whole "the grass is greener on the other side" nonsense. ...
KID syndrome symptoms, causes, diagnosis, and treatment information for KID syndrome (Senter syndrome) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
Errors in copying of genes during cell division can cause numerous diseases, including cancer. Yale school of medicine scientists have unraveled the secrets of a rarer phenomenon.
Green, M C.; Alpert, B N.; and Mayer, T C., "The site of action of the ichthyosis locus (ic) in the mouse, as determined by dermal-epidermal recombinations." (1974). Subject Strain Bibliography 1974. 2251 ...
I am very grateful to everyone who has helped with my fundraisers by donating and raising awareness. It really means a lot to have all of your support and determination to help educate others. This year "It Makes Cents to Help FIRST" is back and running for the entire month. If you would like to participate please contact me at [email protected] Feel free to collect some change at home, even it if adds up to $3. Every penny counts! And help raise awarness by Liking the FIRST Foundations Facebook page. Like and share stories to help make this Ichthyosis Awareness Month a success ...
The purpose of this registry is to support studies aimed at determining the cause of the ichthyoses and treating them more effectively. The Registry offers blinded information about well-characterized groups of individuals with specific diagnoses for study by skin biologists, pharmacologists, and others. The Registry also provides information about research projects to those that have enrolled in the Registry and expressed an interest in participating in studies.. Participants enrolled in the Registry by contacting the registry officials. All participants participated in a phone interview with the study research nurse. Participants were asked about diagnostic testing, treatments, birth history, medical history, degree and type of involvement, current physical condition, and other family members with skin disorders. A quality of life index was embedded in the interview. Participants also indicated whether they would like to be contacted about participating in clinical research. This information ...
A form of congenital ichthyosis inherited as an autosomal-dominant trait and characterized by generalized blistering, erythroderma and severe hyperkeratosis.It is manifested at birth by widespread bullae followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. ...
In the August 26 issue of Science Express, the Yale team describes how one mutated copy of a gene called keratin 10 causes a severe skin disease known as ichthyosis with confetti. However, amidst the diseased skin, these patients also have hundreds to thousands of spots of normal skin. This phenomenon, the researchers report, occurs by the recombination of chromosomes prior to cell division. Instead of producing one normal copy of the gene and one dominant, disease-causing mutation, the exchange between chromosomes results in cells with either two mutant copies or no mutant copies. If the latter occurs, spots of normal, disease-free skin will form. The investigators used these recombination events in spots of normal skin to map and ultimately identify the disease gene.. Patients with a rare skin disease, ichthyosis with confetti, also have spots of normal skin which occur when mutations of disease-causing genes revert to normal during cell division.. "Usually, you have a disease-causing ...
A team of EU-funded researchers has successfully identified a gene that triggers a skin disorder in dogs - and the findings could have implications for humans who also suffer from the condition. Whether it manifests in golden retrievers or in humans, the disease ichthyosis has the same common genetic basis; therefore, any new bounds made in understanding the condition in dogs are applicable to humans too. No molecular cause for ichthyosis has previously been identified.. Humans and dogs tend to suffer from the same conditions. We live together in the same environments and the dogs genetic make-up could hold the key to better understanding the genetic origins of cancer, epilepsy, cardiovascular diseases and diabetes.. The team, from France, Belgium and Germany, received a funding boost from the LUPA (Unravelling the molecular basis of common complex human disorders using the dog as a model system) project, which is funded in part by a EUR 12 million grant under the EUs Seventh Framework ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Hi. This is my first post and Ive been checking this site out for sometime and decided to join. I have had P for about 15 years. It started slowly and then really kicked in. I have it on my stomach, back, knees, elbows and feet. The only time I cleared up was in the summer via tanning in the sun. Completely gone! Need to move to Hawaii. However, during the other times of the year it came back strong! I have tried everything that is ointment related. Some worked but alot didnt, it took like a half hour to apply everday. Found a good derm and he started talking about rets. They scared me, some were really chance taking (all liver related). We decided to start with Soriatane. I was leary because of the blood work and possible side-effects, but I was desperate too. So, I started on 25mg. It started to show in about 2 months, but not completely. So he bumped me 35 mg/day. Cleared me right up. My Lipids shot up too. So I start taking meds for that (Welchol and Gemfibrozal). Now I got that under ...
Evaluation of the efficacy of vorinostat on the basis of overall survival up to 1 year after first administration of the IMP. Investigation on pharmacokinetics und pharmacodynamics of vorinostat. Evaluation of safety and tolerability of vorinostat ...
어린선(魚鱗癬, ichthyosis)은 최소 28개의 아종이 있는 전신 유전성 피부 질환이다. 아종에 관계없이 모든 어린선 환자들은 마르고 딱딱하며 얇은 비늘 모양의 피부를 띤다.[1] 어린선은 물고기를 의미하는 그리스어ichthys에서 유래된 명칭으로 전신에 물고기 비늘같은 인설(scale)을 보이는 질환을 총칭하는 질환군이다. 유전적인 것과 후천적인 것이 있으며 유전적인 것 중 가장 흔한 것은 심상성 어린선이며 주로 사지와 체간의 신전면 표피가 과각질화되어 피부가 물고기 비늘 모양으로 보인다. 후천적 어린선의 피부 모양은 심상성 어린선과 유사하며 림프종을 비롯한 여러 암과 갑상선기능저하증, 유전분증, 홍반성루푸스나 피부근염과 같은 자가면역질환, 후천성면역결핍증, 약제 등과 연관되어 발생할 수 있다.[2] 증상의 경우 심상성 어린선과 같은 미미한 ...
Ichthyosis is a generic term that includes numerous forms of this illness. To this day, 28 different forms have been listed. Ichthyosis is a chronic disease, most of the time of a genetic origin, for which the prevalence depends strongly on the different forms of the illness. ...
Complete information for ICR4 gene (Genetic Locus), Ichthyosis Congenita IV, Ichthyosis-Prematurity Syndrome, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
I had forgotten I bought it originally at a place diagonally across town from me so I went to three other locations before giving up and acting like an intelligent person to call around and see who had it. Beth was kind enough to drive me out to the diagonally opposite end of the Portland metro area to get a replacement. She figured if she drove me, I might not be too wiped out by the energy expenditure to work on it. She would have been right if the next morning I hadnt woken up with cracks on the bottom of my feet. Ahh, I just love my body with all its little joys. Whenever it looks like things are moving along and I get to be at least 50% as active as I would like to be, something acts up, whether its ichthyosis, arthritis, depression, whatever. Thus Ive been sitting on my butt all week long soaking my foot and putting goo on it every few hours in the hopes I could use my toes again soon. Thankfully, it healed quickly mostly cause I was good and did what it takes to make it heal, and you ...
Scott Huckabay - The Guitar Alchemyst. Part 2: Scott Huckabay Photos and Videos. Part 1: Scott Huckabay - The Guitar Alchemyst. by Scott Mowry. ...
Autosomal recessive congenital ichthyosis (ARCI) encompasses several forms of nonsyndromic ichthyosis. Although most neonates with ARCI are collodion babies, the clinical presentation and severity of ARCI may vary significantly, ranging from harlequin ichthyosis, the most severe and often fatal form, to lamellar ichthyosis (LI) and (nonbullous) congenital ichthyosiform erythroderma (CIE). These phenotypes are now recognized to fall on a continuum; however, the phenotypic descriptions are clinically useful for clarification of prognosis and management.
We report the genomic localization by homozygosity mapping and the identification of a gene for a new form of non-syndromic autosomal recessive congenital ichthyosis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. A few patients presented a more generalized lamellar ichthyosis. Palmoplantar keratoderma was present in all cases, whereas only 60% of the patients were born as collodion babies. Six homozygous mutations including one nonsense and five missense mutations were identified in a new gene, ichthyin, on chromosome 5q33 in 23 patients from 14 consanguineous families from Algeria, Colombia, Syria and Turkey. Ichthyin encodes a protein with several transmembrane domains which belongs to a new family of proteins of unknown function localized in the plasma membrane (PFAM: DUF803), with homologies to both transporters and G-protein ...
Ichthyosis vulgaris treatment options clinically. Harlequin type ichthyosis symptoms dead skin treatment options. What is vulgaris lamellar ichthyosis treatment? what causes ichthyosis skin disease option
TY - JOUR. T1 - The phenotype spectrum of X-linked ichthyosis identified by chromosomal microarray. AU - Hand, Jennifer L.. AU - Runke, Cassandra K.. AU - Hodge, Jennelle C.. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Background Steroid sulfatase (STS) gene disruption causes X-linked ichthyosis (XLI). Interrogating the entire genome through chromosomal microarray (CMA), a test primarily used to screen patients with noncutaneous congenital anomalies, may detect STS deletions incidentally. Objective We sought to determine the variability of skin features associated with STS deletions diagnosed through CMA and to compare these findings with XLI cases reported in the literature and recognized in a dermatology clinic. Methods Male patients with an STS deletion were identified from 23,172 consecutive postnatal blood samples tested with CMA at Mayo Clinic. A comparison group of male patients with biochemically confirmed XLI was ascertained in the dermatology clinic. The available patient medical records, skin ...
The term has been used to describe several different, rare, severe disorders of keratinisation characterized by massive hyperkeratosis. The term has also been employed to describe localized and linear warty epidermal nevi sometimes associated with mental retardation, seizures or skeletal anomalies. A few exceedingly rare syndromes may be classified as forms of ichthyosis hystrix in the strict sense: - ICHTHYOSIS HYSTRIX GRAVIOR - LAMBERT TYPE, a condition characterized by hyperkeratoses covering the entire body except for the face, genitals, palms and soles. It was first described in the Lambert family in Britain at the beginning of the 18th century. - ICHTHYOSIS HYSTRIX GRAVIOR - CURTH-MACKLIN TYPE, a disorder characterized by hystrix-like changes and keratoses of the palms and soles. The histological findings differ from those of all other ichthyoses. - ICHTHYOSIS HYSTRIX GRAVIOR - RHEYDT TYPE, a condition consisting of keratoses especially on the extremities including the flexor surfaces and ...
Background. Oral liarozole, a retinoic acid metabolism-blocking agent, may be an alternative to systemic retinoid therapy in patients with lamellar ichthyosis.. Objective. To demonstrate the efficacy and safety of once-daily oral liarozole in the treatment of moderate/severe lamellar ichthyosis.. Methods. This was a double-blind, multinational, parallel phase II/III trial (NCT00282724). Patients aged ,= 14 years with moderate/severe lamellar ichthyosis [ Investigators Global Assessment (IGA) score ,= 3] were randomized 3 : 3 : 1 to receive oral liarozole (75 or 150 mg) or placebo once daily for 12 weeks. Assessments included: IGA; a five-point scale for erythema, scaling and pruritus severity; Short Form-36 health survey; Dermatology Life Quality Index (DLQI); and safety parameters. The primary efficacy variable was response rate at week 12 (responder: ,= 2-point decrease in IGA from baseline).. Results. Sixty-four patients were enrolled. At week 12, 11/27 (41%; liarozole 75 mg), 14/28 (50%; ...
Signs of Corneal dystrophy - ichthyosis - microcephaly - mental retardation including medical signs and symptoms of Corneal dystrophy - ichthyosis - microcephaly - mental retardation, symptoms, misdiagnosis, tests, common medical issues, duration, and the correct diagnosis for Corneal dystrophy - ichthyosis - microcephaly - mental retardation signs or Corneal dystrophy - ichthyosis - microcephaly - mental retardation symptoms.
X-linked ichthyosis is a relatively common genetic disorder of keratinization. It is the second most common type of ichthyosis after vulgaris. The incidence is estimated to be between 1 in 2,000 and...
TY - JOUR. T1 - Involucrin expression in keratinization disorders of the skin - a preliminary study. AU - Kanitakis, J.. AU - Zambruno, G.. AU - Viac, J.. AU - Thivolet, J.. PY - 1987. Y1 - 1987. N2 - We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Dariers disease (49%), Flegels disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichthyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that ...
Collodion is a flammable, syrupy solution of pyroxylin (a.k.a. "nitrocellulose", "cellulose nitrate", "flash paper", and "gun cotton") in ether and alcohol. There are two basic types: flexible; non-flexible. The flexible type is often used as a surgical dressing or to hold dressings in place. When painted on the skin, collodion dries to form a flexible nitrocellulose film. While it is initially colorless, it discolors over time. Non-flexible collodion is often used in theatrical make-up. In 1846 Louis-Nicolas Ménard and Florès Domonte discovered that cellulose nitrate could be dissolved in ether. They devised a mixture of ether (ethoxyethane) as the solvent and ethanol as a diluent that rendered cellulose nitrate into a clear gelatinous liquid. Collodion was first used medically as a dressing in 1847 by the Boston physician John Parker Maynard. The solution was dubbed "collodion" (from the Greek κολλώδης (kollodis), gluey) by Dr. A.A. Gould of Boston, Massachusetts. In 1851, Frederick ...