Diseases or tumors of the pituitary gland or the hypothalamus are one cause of hypothalamic amenorrhea. The hypothalamus is an area of the brain that controls hormone production. The hypothalamus tells the pituitary gland to signal the reproductive glands to make hormones. A disruption in this delicate chain of command can result in an estrogen deficiency. Estrogen is essential for regulating the menstrual cycle. A progestin challenge test is used to determine if a lack of estrogen is the problem. Other tests used in the diagnosis of hypothalamic amenorrhea may include laparoscopy, imaging, physical exam, pelvic exam, blood tests, and a pregnancy test.. Oral contraceptives are prescribed as a treatment for both hypothalamic amenorrhea and polycystic ovary disease. If the problem stems from thyroid or pituitary disturbances, different medications will be prescribed. People who have had previous central nervous system chemotherapy or radiation may develop hypothalamic amenorrhea. Young female ...
Hypothalamic Amenorrhea - This forum is for those diagnosed with Hypothalamic Amenorrhea. Please keep in mind this is a forum for those actively in tr
Children with ROHHAD are seemingly normal before the rapid-onset weight gain, making the diagnosis even more challenging to parents and health care personnel. Between 1.5 and 7 years of age, these children begin to manifest abnormalities that will evolve into the features of ROHHAD. Most commonly, the first sign is dramatic (often 20-30 pounds) and rapid (over 6 to 12 months) weight gain with associated abnormal increase in hunger (hyperphagia). This rapid-onset obesity is considered a sign of hypothalamic dysfunction (abnormality of the endocrine system). Other hypothalamic abnormalities may not be detected at the time of the rapid weight gain, but will be identified any time from months to years following the rapid-onset obesity. These other hypothalamic/endocrine abnormalities may include inability to maintain normal water balance in the body (leading to abnormally high or low sodium levels), high prolactin levels, low thyroid hormone, early or late puberty, and low cortisol among other ...
Hypothalamic amenorrhea (HA) is a one of the main causes of functional reproductive disorder in females. The condition involves the cessation of menstrual cycles in pre-menopausal women in the absence of any specific organic failures (no ovarian cancer, pituitary tumors, etc.). HA can be caused by many environmental factors, but the three leaders are: stress,…
Julie Duffy Dillon is a Fat Positive Dietitian, PCOS Specialist, and Food Behavior Expert who partners with people along their Food Peace journey.. In this episode I talk to Julie about PCOS and how she supports women with this condition without restrictive weight loss diets.. Julie shares with us some of the common struggles women with PCOS experince such as confusion, hunger, weight gain, their relationship with food, poor body image, stress and anxiety and difficulty in falling pregnant and HOW she helps them.. We also talk about the difference between Hypothalamic Amenorrhea in terms of treatment/management and diagnosis.. For more on Julie visit her website, Instagram (@foodpeacedietitian) or Podcast - Love Food. More information on my services: ...
Heres the notes for episode #094 of The Paleo Women Podcast. Be sure to check back every Tuesday for a new episode, and head over to iTunes or Stitcher to subscribe!. To leave a review for the podcast (HORRAY!), go to: http://coconutsandkettlebells.com/review. In this episode, Stefani and Noelle discuss PCOS and hypothalamic amenorrhea, pooping concerns, & the copper IUD.. Got a question youd like us to answer? Email us at [email protected] 10% of the funds we receive from our sponsors is donated directly to our partner charity, Thistle Farms, a place where women survivors of abuse, addiction, trafficking and prostitution receive help and support through residential programs, therapy, education, and employment opportunities. Because we get paid per download, you are actively supporting Thistle Farms by downloading our podcast each week.. ...
Hypothalamic-pituitary disease is a well-recognized, although uncommon, occurrence in sarcoidosis. Almost always the endocrine manifestations occur in a patient with widespread disease involving the lungs, skin or liver. A case is reported of central nervous system (CNS) sarcoidosis with no other clinical, biochemical or histological evidence of the disease.. ...
... refers to a condition in which the hypothalamus is not working properly. The hypothalamus produces hormones that control body temperature, hunger, moods, release of hormones from many glands such as the pituitary gland, sex drive, sleep, and thirst. The signs and symptoms patients have vary depending on the hormones missing. A number of different causes including anorexia, bleeding, genetic disorder, tumors, and more have been linked to hypothalamic dysfunction. Treatment depends on the cause of the hypothalamic dysfunction ...
Hi Nico, I also wanted to thank you for this info. I have been diagnosed with HA as well, however my profile does not quite fit the normal profile in that Im not underweight or do excessive sport, but it appears that I have this problem due to excessive stress levels. It also appears that my body went into this sort of hybernation (HA is basically the pituitary gland hybernating) because I used an Implanon which was inserted after I had my son 4 years ago. The Implanon depresses the function of the pituitary gland and it appears that this is what tipped me over the edge into HA. I have had the Implanon removed in May 2007 and have not had any periods since. I have not reacted to the provera withdrawl bleed and the MRI has ruled out pituitary tumor/sheehans syndrom. I should add that before Implanon I was on the loette and never had any period issues or issues conceiving my son. It seems that women with Type A personalities are more prone to HA especially in combination with a depressant such ...
Hi Nico, I also wanted to thank you for this info. I have been diagnosed with HA as well, however my profile does not quite fit the normal profile in that Im not underweight or do excessive sport, but it appears that I have this problem due to excessive stress levels. It also appears that my body went into this sort of hybernation (HA is basically the pituitary gland hybernating) because I used an Implanon which was inserted after I had my son 4 years ago. The Implanon depresses the function of the pituitary gland and it appears that this is what tipped me over the edge into HA. I have had the Implanon removed in May 2007 and have not had any periods since. I have not reacted to the provera withdrawl bleed and the MRI has ruled out pituitary tumor/sheehans syndrom. I should add that before Implanon I was on the loette and never had any period issues or issues conceiving my son. It seems that women with Type A personalities are more prone to HA especially in combination with a depressant such ...
Delay of the menstrual cycle and abnormal menses has been shown to be a risk factor for scoliosis progression. Orthopedic treatment alone is not enough.
I first had symptoms when i was 17 and was told that i had PCOS (thin people type PCOS) and was officially diagnosed at 22 ans now i am 35. I have always had regular periods and unless on birth control pills were they irregular at times and I had a hard time getting pregnant because of the absent periods. I was always told by doctors that I would have a hard time conceiving so I would only go on the pill periodically which i did for more than 4 years, not for protection against getting pregnant, but just to get a period (since I was told its not healthy to have less than 4 or so periods a year). Last time I went on a 3 month birth control pill and then stopped again because the medicine was not curing my pcos nor making me get pregnant. I went in search for a cure and ended up with so many drugs, medicine and even soaps that didnt work. I actually thought at a point that i was cursed that there is no cure for it, i was prepared to live like that till i read a testimony of a patient who ...
Feeling fat & lazy when recovering form HA is normal! Here are quick tips to stop the downward thought spiral and boost your confidence.
MANCHESTER, England -- Injections of a natural human peptide hormone called kisspeptin restored reproductive hormones to potentially functional levels in women with hypothalamic amenorrhea, researcher
Empolyment take over-the-counter laxatives with out first consulting your midwife or doctor. Then the pfegnancy of the surgical procedure is cleaned and the woman is moved to post operative area. My AF in Feb was actually gentle and quick and this month it has been the identical. Assessments for male infertility attempt to find out whether or not any pregnancy employment law in california those processes are impaired. I pregnancy employment law in california a primary time mother and this has been the worst pregnancy app Ive ever used. Restoration in ovarian exercise in women with practical hypothalamic amenorrhea who had been handled with cognitive behavioral therapy. Prenatal fetal electroencephalography. Its possible youll feel rapid adjustments in temper within the early levels of pregnancy, and even begin to cry sometimes, with out realizing why. The most dependable approach in 2015 to preserve a patients fertility is thru egg harvesting prior to chemotherapy and preegnancy vitro ...
im a healthy 22 year old female. the only long term medicine ive ever been on is birth control, although thats what has caused my problems. i had hypothalamic amenorrhea, so my doctor put me on the pill to make my periods normal. the pill did help normalize my period, but when i came off of the pill for the first time, my mystery symptoms began. as soon as i came off of the pill, i slowly started to lose my appetite. it gradually got worse so not only did i not have any food cravings, but i lost my sense of fullness and satiety. having no sense of fullness led me to binge eat because i would keep eating to try to get full, so i gained about 10-15 pounds. no matter how much i ate, i would never feel full. so then i was put back on the pill and something incredible happened. slowly, i began to regain not only my hunger, but my sense of fullness too ...
OBJECTIVE: The diagnosis of GH deficiency in adults relies on the results of GH provocative testing. Whilst in some patients the testing strategy is clear, this is not the case in all patients. The objective of this study was to further examine the concordance between the GH responses to two different provocative stimuli, to correlate this with the number of additional pituitary hormone deficits, and to produce guidelines as to which patients require two GH provocative tests and which require only one. STUDY DESIGN AND PATIENTS: The results of GH provocative tests were reviewed in 103 patients (mean age 28 years, 48 male), with documented or potential hypothalamic-pituitary disease and 35 normal volunteers (mean age 21 years, 18 male). All patients and normal volunteers underwent an insulin tolerance test (ITT) and an arginine stimulation test (AST). Severe GH deficiency was defined as a GH response to an ITT of , 5 mU/l and a GH response to an AST of , 2 mU/l, utilizing data from previous ...
Natalie is a ROHHAD child from Malaysia. We met her and her mother on Facebook and have come to know them very well when they joined our ROHHAD site. On April 26th Natalie fell in to a coma while at the hospital. We are extremely happy to report that Natalie has come out of the coma and is smiling. She has shown us the strength and will she has to fight this horrible syndrome ...
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People stare and believe it or not, people say stuff. People come up and say stuff about how our children are fat and that we should be ashamed of ourselves as parents and how we are ruining our childs life. Im sorry but I want to go insane on these people but out of respect for my daughter I keep it as civilized as I can. I cant promise that Im always civilized. I know all of us as parents with ROHHAD children are going through this. AND I shouldnt have to lock my daughter in her house so she wont be stared at by ADULTS! Anyway, I hear all of you and I completely understand what all of you are going through...we just have to be there for each other ...
A 2-year-old girl, with bifid epiglottis, imperforate anus, and mesoaxial and postaxial polysyndactyly (figure 1), first developed focal seizures at 3 months of age with subsequent progression to generalized seizures. Her epilepsy is well-controlled with carbamazepine and her development is normal. EEG was normal. MRI brain revealed hypothalamic hamartoma (figure 2). Targeted next-generation sequencing revealed a de novo pathogenic variant (c.2149C , T;p.Gln717*) in GLI3, confirming Pallister-Hall syndrome, which is inherited in an autosomal dominant pattern. Its primary feature is hypothalamic hamartoma, which can result in hypopituitarism and epilepsy (classically gelastic), which responds well to antiepileptic medications.1 ...
Hi in the past I was diagnosed with primary amenorrhea, after seeing a specialist he has now said it is hypothalamic amenorrhea. I guess my question is does anyone know of any natural treatments I can do to begin my periods. I am desperately eager to have a baby and I know that injectibles are an option for me, but I wanted to try a natural approach first. I was informed that through all my tests that everything appears normal, however I still do not have a cycle. Please help with any useful information.. Reply Follow This Thread Stop Following This Thread Flag this Discussion ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Womens and Childrens Health. (Barnneurologisk forskning/Ahlsten) ...
Stefani, I appreciate your unique blog and all the great information that you share. A couple of years ago, your cautionary post on intermittent (and other types of) fasting by women helped me a lot, and since then, at various times, in the comment sections of newspaper/magazine articles and other blogs articles about fasting, I have posted a link to that article by you so women who are thinking of doing some kind of fast will have a more nuanced understanding of what it might entail for them (as females).. Regarding the topic of hypothalmic amenorrhea and other endocrinological issues, I would like to mention to readers who have not received hypothalmic amenorrhea as an "official" diagnosis by a doctor, but who have an array of confusing symptoms and are trying to figure out what it might mean, that what they are dealing with may not be this, but may be another endocrinological problem. One of the readers who commented earlier here mentioned that her doctors had looked into endometriosis, ...
In this report, we showed the subject with hypothalamic hypopituitarism which was diagnosed based on the following findings: excess and delayed reaction of ACTH in CRH load test, delayed reaction of LH and FSH in LHRH load test, poor GH reaction in arginine load test. Although we understood that it would be important to perform insulin tolerance test in order to reconfirm the dysfunction of the hypothalamus in this subject, we failed to obtain the agreement from this subject about the insulin load test due to the risk of the occurrence of hypoglycemia. It was reasonable that this subject was very afraid of the occurrence of hypoglycemia because she experienced severe hypoglycemia repeatedly. Therefore, we decided not to perform insulin tolerance test in this subject. The GH releasing hormone + arginine (GHRH + ARG) test is the best method to accurately evaluate GH secretion. However, according to the Japanese guideline for adult GH deficiency (The hypothalamic-pituitary dysfunction study group ...
Objective: To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA. Design: Randomized controlled trial. Setting: Clinical research center at an academic medical university. Patient(s): Seventeen women with FHA were randomized either to CBT or observation. Intervention(s): CBT versus observation. Main Outcome Measure(s): Circulatory concentrations of cortisol, leptin, thyroid-stimulating hormone (TSH), total and free thyronine (T 3 ), and total and free thyroxine (T 4 ) before and immediately after completion of CBT or observation. (Each woman served as her own control.) Result(s): Cognitive behavior therapy but not observation reduced cortisol levels in women with FHA. There were no changes in cortisol, leptin, TSH, T 3 , or T 4 levels in women randomized to ...
Functional Hypothalamic Amenorrhea (FHA), the spontaneous cessation of the menstrual cycle for at least 6 months after menstrual cyclicity has been established, is a common and reversible form of anovulation not due to discernible organic causes. Whereas animal studies suggest an interaction of metabolic and psychosocial stress in the genesis of FHA, the distinct central mechanisms in humans are not clear. On a behavioral level, FHA appears to depend on a complex interplay between individual stress susceptibility, stressful life events, and enduring metabolic challenge due to inappropriate attitudes towards eating and body image. We will use a comparison group of ovulatory, eumenorrheic women (EW) and a contrast group of lean women with polycystic ovary syndrome (PCOS). Although women with FHA and PCOS present with anovulation, each condition differs markedly in pathobiology (and health burden). Contrasting women with FHA to those with PCOS will afford an opportunity to understand more about the ...
Hypogonadism is separated into two types: primary hypogonadism (resulting from dysfunction of the testis or ovary) or central hypogonadism (resulting from pituitary or hypothalamic dysfunction that leads to loss of lutenizing horomne [LH] and follicle-stimulating hormone [FSH]).. Causes of hypogondaism include genetic, menopausual, autoimmune, viral, radiation, and chemotherapeutic agents. Central hypogonadism is often due to pituitary adenomas. Through compression of the gland, these tumors can cause destruction of pituitary tissue or interference with gonadotropin-releasing hormone (GnRH) input from the hypothalamus. Gonadotropin dysfunction is the second most common hormonal disorder from compression of the pituitary gland from a pituitary adenoma after GH suppression. Hypothalamic disorders such as tumors and hypothalamic amenorrhea, as well as exposure to radiation, can lead to hypogonadism. Fasting, weight loss, anorexia nervosa, bulimia, exercise, or stressful conditions result in defects ...
Shapiro syndrome is an extremely rare disorder consisting of paroxysmal hypothermia (due to hypothalamic dysfunction of thermoregulation), hyperhydrosis (sweating), and agenesis of the corpus callosum with onset typically on adulthood. The disease affects about 50 people worldwide. The duration and frequency of the episodes vary from person to person, with some episodes lasting hours to weeks and occurring from hours to years. Very little is known about the disease due to the small number of people affected. Shapiro Syndrome, Genetic and Rare Diseases Information Center (GARD), National Institutes of Health "Shapiro syndrome" Shenoy C. QJM. 2008 Jan;101(1):61-2. PMID 18203725 "Shapiro syndrome with hypothalamic hypothyroidism" Arkader R, Takeuchi CA. Arq Neuropsiquiatr. 2008 Jun;66(2B):418-9. PMID 18641886 "Subtotal corpus callosum agenesis with recurrent hyperhidrosis-hypothermia (Shapiro syndrome)" Tambasco N, Corea F, Bocola V. Neurology. 2005 Jul 12;65(1):124. PMID ...
A hypothalamic hamartoma (HH) is a rare developmental malformation associated with seizures of varying semiology, including Gelastic seizures [1, 2, 3, 4]. The hamartoma is typically located on the ventral portion of the hypothalamus near the mammillary bodies [5]. The presence of a HH is linked with cognitive decline and behavioral issues, as well as the early onset of puberty [1, 5, 6]. Roughly half of all patients with HH have either focal or general cognitive deficits of varying severity (with some ultimately declining to the point of intellectual disability), and around one-third have behavioral difficulties including ADHD, violent outbursts, conduct disorder, and co-morbid psychiatric conditions [5, 7, 8]. The cognitive decline and behavioral disturbances observed in patients with HH are linked with both the size and location of the hamartoma, as well as seizure frequency [5]. As for treatment options, anti-epileptic drugs have poor efficacy in this population and a surgical approach (e.g. ...
Medication: Birth control pills can stimulate and regulate the menstrual period if a woman is not trying to get pregnant. Infertility patients with PCOS may start with Clomiphene Citrate, a medication designed to stimulate the ovaries to produce multiple follicles and eggs. Other fertility drugs - Human Chorionic Gonadotropin (HCG) and Human Menopausal Gonadotropin (HMG) - also may be prescribed if Clomiphene Citrate alone is not effective. Finally, Progesterone may be necessary to help thicken the uterine lining and sustain pregnancy.. Medication also is available to suppress overproduction of Prolactin caused by Hyperprolactinemia. In cases of Hypothalamic Amenorrhea, Gonadotropins (LH and FSH) are prescribed to regulate levels of these hormones.. Ovulation Induction (OI): Used alone or with Insemination, OI relies on fertility drugs to stimulate development of the follicles and eggs. For this reason, it can be an effective treatment for various forms of ovulatory dysfunction and Luteal phase ...
Our our bodies are related: the healthier we are physically before being pregnant, the higher the surroundings to maintain a healthy being pregnant. Our plan is to have a home delivery. If you grow to be pregnant, your bodys hormones soar onto a rollercoaster of highs and lows. Otherwise you will drive yourself pregnancy after methotrexate injection in search of signs which will or may not present, she methltrexate. It is vaginal itching during early pregnancy about discovering what works for you finest. Anyway - to my level. Yet if Im being honest, it was different to how I expected all of it to be. Iodine supplements pregnancy after methotrexate injection being methotredate and lactation - United States and Canada: recommendations of the American Thyroid Association. Group I: hypothalamic pituitary failure (hypothalamic amenorrhea or hypogonadotrophic hypogonadism). National Collaborating Centre for Girlss and Youngsterss Health. Smoking cigarettes can impair each male and female ...
October 9, 2013 Infertility is often a symptom of an underlying health condition. For women, conditions like PCOS or Hypothalamic Amenorrhea result in anovulation and could be indicative of endocrine system hormone imbalances. Sometimes balancing diet and exercise can restore a womans menstrual cycle. As it turns out, this concept also applies to men. Male factor infertility is responsible for about half of all infertility cases, and as many as 40% of infertility cases are the combined result of both male factor and female factor infertility. It is important for men and couples to be educated on male factor infertility and to seek an evaluation to rule out hormone imbalances resulting from poor diet and lack of exercise, cancers, or other underlying health conditions which manifest through poor sperm quality or quantity.
Sperm lie subsequent to the neck of the is it safe to eat mascarpone during pregnancy (cervix) when a man comes (ejaculates) during sex. Nasal pits are additionally forming. Some reasons for having a missed or late interval with out being pregnant include: ovulation issues or ovarian reserve issues Circumstances like Polycystic Durong Syndrome (PCOS)Hypothalamic Amenorrhea, and excessive Follicle Stimulating Hormone (FSH) or Premature Ovarian Failure (POF) can intervene together with your menstrual cycle. I met is nausea without vomiting a pregnancy symptom many wonderful and kind individuals. I used is it safe to eat mascarpone during pregnancy be in utter shock hip pain from pregnancy his dimension - 10. When youve got a foul headache that lasts for greater than two or three hours, along with vision disturbances and have sudden swelling in your hands, eyes and face, you might have pre-eclampsia (NCCWCH 2003:ninety nine). The ultrasound will affirm the being pregnant and may indicate the ...
It is well known that circulating adiponectin concentrations are reduced in animal models of obesity and in patients with obesity or metabolic syndrome, despite adipocyte hypertrophy or increased body fat (2-6). However, the details of adiponectin production and release have varied among studies, especially in animal models (10,28,29,32,33). This is probably due to the apparently different etiology of the three types of obese animal models: genetic, diet-induced, and hypothalamic obesity (20,34).. VMH lesion-induced hypothalamic obesity in animals is the only obesity model that shows clear derangements of autonomic nervous activities (hyperactivity of the vagus nerve and hypoactivity of sympathetic nerves) compared with genetic (20), diet-induced obesity (34), and other types of hypothalamic obesity (19). Thus, there is a possibility that this animal model has different characteristics of adiponectin production and release, with resultant change of serum adiponectin, compared with those of other ...
Sweet Pea Diapers, Nappy Shoppe and Eylas Imports have collectively grouped together to offer a very limited amount of CAMO wet bags to join the fight against ROHAD (Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation and Autonomic Dysregulation.) ...
The long-term effects of radiotherapy and chemotherapy are becoming increasingly recognized as the cure rates of certain childhood malignancies improve. The endocrine system is particularly sensitive to cancer therapies. Long-term survivors of childhood cancer who received cranial irradiation have been shown to have lower than predicted height, an increased prevalence of obesity and reductions in strength, exercise tolerance, bone mineral density, quality of life and academic achievement. Growth hormone deficiency (GHD) is the most frequent endocrine deficiency observed following cranial irradiation. Adults with GHD resulting from primary hypothalamic-pituitary disease during childhood have been shown to exhibit a clinical picture similar to that described in long-term survivors of childhood cancer: increased fat mass and reduced lean mass, strength, exercise tolerance, bone mineral density and quality of life. This review considers the possible contribution of GHD to the adverse sequelae ...
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Comparisons of hypothalamic dysfunction between Huntington’s Disease (HD) patients and rodent models of HD have not always yielded similar results. Cortisol levels in HD patients have been contradictory, with reports ranging from hypo- to hypercorticoidism of morning measurements. Initial reports of major elevations in circulating corticosterone levels in the R6/2 mouse model of HD have only been followed up in one other closely related model, the R6/1 mouse, and the results were not perfectly congruent. To determine if abnormal stress hormones were a characteristic of disease, we examined diurnal and stress-induced corticosterone levels in multiple HD mouse models ...
Anteverted Nostril, Buccal Frenulae, Seizure Symptom Checker: Possible causes include Pallister-Hall Syndrome, Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome, Pallister W Syndrome. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Source: Adapted from the National Institutes of Health. What does the term "amenorrhea" mean? The term "amenorrhea" refers to absence of menstrual periods. To find out more about this term, please search the news section of this website for related articles and information.. ...
there are several other reasons why a woman can stop seeing her menses. Here are ten possible causes of amenorrhea in women to look out for
Treatment is determined by the etiology of the amenorrhea and the desires of the patient. Ideally, treatment should be directed at correcting the underlying pathology. In the case of outflow tract abn... more
၃။ မဂၤလာပါဆရာ။ အသက္ ၂ဝ ႏွစ္ ၉ လ။ အမ်ိဳးသမီး (အပ်ိဳ)။ လက္ရွိေနရပ္ ႕႕႕႕႕ (ျမန္မာႏိုင္ငံသား)။ ဆရာ ကြ်န္မ လြန္ခဲ့တဲ့ ႏွစ္ႏွစ္ခန္႔ကတည္းက ဓမၼတာထိန္လို ့ေဆးျပခဲ့ပါတယ္။ ultrasound ရိုက္ျပီး ေရအိတ္အေသးေလး ေတြေတြ႔၍ ေဆးေသာက္ရန္ ညႊန္ၾကားခဲ့ပါတယ္။ အဆိုပါေဆးစေသာက္ကတည္းက ပံုမွန္ဓမၼတာျပန္လာပါတယ္။ ဒါေပမဲ့ တႏွစ္ေလာက္အထိ မထူးျခား၍ အျခားဆရာဝန္ႏွင့္ ေျပာင္းျပခဲ့ပါတယ္။ အဆိုပါ ဆရာဝန္မွ ...
Central precocious puberty (CPP) is caused by premature activation of the hypothalamic-gonadal axis, and must be treated adequately. In particular, CPP that occurs at a relatively young age or in boys is likely to be caused by an organic lesion. Hypothalamic hamartoma (HH) is the most common organic cause of CPP. The present case report describes an 11-month-old female infant who presented with vaginal bleeding and rapidly progressive secondary sex characteristics from the age of 6 months. She was diagnosed with CPP following the detection of HH via magnetic resonance imaging. The infant girl was successfully treated with gonadotropin-releasing hormone agonist. After 6 months, her breast had regressed and clinical and radiological follow-up demonstrated stable findings with no evidence of tumor growth or secondary sexual characteristics until the fourth year after the initiation of treatment. This patient is the one of the youngest infants presenting with CPP and HH in Korea; treatment was successful
Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD syndrome) is a very rare disease affecting approximately 75 people worldwide. Patients with ROHHAD, as well as patients with congenital central hypoventilation syndrome (CCHS) have damage to the mechanism governing proper breathing. ROHHAD syndrome is a disease that is potentially lethal and incurable. Fifteen patients with ROHHAD were evaluated by Diego Ize-Ludlow et al. work published in 2007. The variable presentation of ROHHAD includes the following main symptoms: Hyperphagia and obesity by age of 10 years - (median age 3 years); Respiratory Manifestations: Alveolar Hypoventilation (median onset age 6.2 years); Cardiorespiratory arrest; Reduced Carbon Dioxide Ventilatory Response; Obstructive sleep apnea. Thermal or other hypothalamic dysregulations, with autonomic dysregulation by median age 3.6 years:Failed Growth Hormone Stimulation; Adipsic hypernatremia (inability to feel thirst to ...
The primary feature of Pallister-Hall syndrome is the hypothalamic hamartoma. Other major manifestations of the syndrome include polydactyly, dysplastic nails, bifid epiglottis, imperforate anus, renal anomalies, pituitary dysplasia, and hypopituitarism (5).. In familial cases, Pallister-Hall syndrome has been noted to be inherited in an autosomal dominant pattern with variable expressivity. It has been linked with a mutation to a zinc finger transcription factor gene, GLI3, which resides on chromosome 7p13 in some inherited probands (6, 7). Mutations to the GLI3 gene have been associated also with Greig cephalopolysyndactyly syndrome.. Histologic examination of the hypothalamic lesions in patients who died as neonates demonstrated primitive germinal cells, which indicated a neoplastic potential (1, 8). For this reason, the term hypothalamic hamartoblastoma was assigned initially to these tumors. Subsequent pathologic examination of tumors from older patients with Pallister-Hall syndrome, ...
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission. The importance of these events in cell physiology and pathology has been partially unraveled with the identification of the genes responsible for the catalysis of mitochondrial fusion and fission. Mutations in two mitochondrial fusion genes (MFN2 and OPA1) cause neurodegenerative diseases, namely Charcot-Marie Tooth type 2A and autosomal dominant optic atrophy. Alterations in mitochondrial dynamics may be involved in the pathophysiology of prevalent neurodegenerative conditions. Moreover, impairment of the activity of mitochondrial fusion proteins dysregulates the function of hypothalamic neurons, leading to alterations in food intake and in energy homeostasis. Here we review selected findings in the field of mitochondrial dynamics and their relevance for neurodegeneration and hypothalamic dysfunction.
Dacrystic seizures. Dacrystic seizures are rare, occurring with an estimated frequency of 0.13% in patients admitted for long-term video monitoring.1 Seizures are characterized by stereotyped crying and may encompass lacrimation, sobbing, or sad facial expression. They most commonly occur along with gelastic seizures and/or generalized tonic-clonic seizures. A hypothalamic hamartoma is usually the cause when patients have both dacrystic and gelastic seizures, whereas isolated dacrystic seizures are typically associated with mesial temporal sclerosis. The proposed pathophysiology is thought to be from excitation of neurons in the hypothalamus or secondary to a hypothalamic autonomic release phenomenon from disinhibited regulatory cortex. Dacrystic seizures are often medically refractory, with no guaranteed improvement after epilepsy surgery. ...