The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before and after 2 years of GH replacement. CH patients (CH, n = 1080) were compared with TSH sufficient patients (TSHsuff n = 515) as one group and divided by thyroxine dose/kg/day into tertiles (CHlow-mid-high). Anthropometry, fasting glucose, glycosylated haemoglobin (HbA1c), blood pressure, lipids, IGF-I SDS, quality of life and morbidity were studied. Analyses were standardized for gender, age, number and types of pituitary insufficiencies, stimulated GH peak, age at GH deficiency onset, aetiologies and, when appropriate, for weight and GH dose. At baseline, TSHsuff patients did not differ from CH or CHmid in any outcome. CHlow (a parts per thousand currency sign1.18 mu g ...
Background: Lymphocytic hypophysitis and Sheehan s syndrome are rare disorders predominantely affecting women in the peripartum period. Patients usually present with various degrees of hypopituitarism and/or symptoms of a pituitary mass lesion.. Material and methods: We present two case-histories of postpartum hypopituitarism. We have also performed a review of literature from Medline and Pubmed databases.. Results and interpretation: Sheehan s syndrome is a pituitary necrosis due to hypotension during an obstetric bleeding. Lymphocytic hypophysitis is a chronic inflammatory process of the anterior pituitary gland, where the pathogenesis is believed to be autoimmune. The diagnoses should be considered when women present peripartum with non-specific symptoms related to varying deficiencies of anterior pituitary hormones, and/or headache and/or visual disturbances.. The treatment of hypopituitarism mainly consists of hormone-replacement therapy with careful follow-up ...
Sheehans syndrome, also known as postpartum pituitary gland necrosis, is hypopituitarism (decreased functioning of the pituitary gland), caused by ischemic necrosis due to blood loss and hypovolemic shock during and after childbirth. The various signs and symptoms in Sheehans syndrome are caused by damage to the pituitary, which causes a decrease in one or more hormones it normally secretes (see Pathophysiology section). Since the pituitary controls many glands in the endocrine system, partial or complete loss of a variety of functions may result. Most common initial symptoms of Sheehans syndrome are agalactorrhea (absence of lactation) and/or difficulties with lactation. Many women also report amenorrhea or oligomenorrhea after delivery. In some cases, a woman with Sheehan syndrome might be relatively asymptomatic, and the diagnosis is not made until years later, with features of hypopituitarism. Such features include secondary hypothyroidism with tiredness, intolerance to cold, ...
Hypopituitarism in Children What is hypopituitarism? Hypopituitarism, also called an underactive pituitary gland, is a condition that affects the anterior (front) lobe of the pituitary gland - usually resulting in a partial or complete loss of functioning of that lobe. The resulting symptoms depend on which hormones are no longer being produced by the gland. Because the pituitary gland affects the other endocrine organs, effects of hypopituitarism may be gradual, or sudden and dramatic. What causes hypo...
Hypopituitarism in Children What is hypopituitarism? Hypopituitarism, also called an underactive pituitary gland, is a condition that affects the anterior (front) lobe of the pituitary gland - usually resulting in a partial or complete loss of functioning of that lobe. The resulting symptoms depend on which hormones are no longer being produced by the gland. Because the pituitary gland affects the other endocrine organs, effects of hypopituitarism may be gradual, or sudden and dramatic. What causes hypo...
phdthesis{1a2f457d-a0f0-40b9-a3b2-daf2e925adf8, abstract = {Premature atherosclerosis, cardiovascular risk factors and increased cardiovascular mortality have been shown in patients with hypopituitarism on conventional hormone treatment, but without growth hormone (GH) replacement. The aims of paper I-III were to investigate separately the risks for cerebrovascular and cardiac mortality as well as the incidence of cardiovascular disease in patients with hypopituitarism and to assess the long-term prognosis for patients with craniopharyngioma. GH replacement has been associated with an impairment of glucose tolerance and the objectives of paper IV-V were to investigate whether individualized GH replacement therapy could avoid such a deterioration. There was a 1.75-fold increased cardiovascular mortality in 344 hypopituitary patients operated for a pituitary tumour compared to the general population. The risk for death in cerebrovascular disease was higher than for cardiac disease and females had ...
Review article Urban RJ, et al. Brain Inj. 2005. Show full citation Abstract PRIMARY OBJECTIVES: To review evidence that there exists a substantial sub-population of patients with endocrine disorders as a result of traumatic brain injury (TBI) and to underscore the importance of screening patients with TBI considered most at risk for hypopituitarism with the…
In this report, we showed the subject with hypothalamic hypopituitarism which was diagnosed based on the following findings: excess and delayed reaction of ACTH in CRH load test, delayed reaction of LH and FSH in LHRH load test, poor GH reaction in arginine load test. Although we understood that it would be important to perform insulin tolerance test in order to reconfirm the dysfunction of the hypothalamus in this subject, we failed to obtain the agreement from this subject about the insulin load test due to the risk of the occurrence of hypoglycemia. It was reasonable that this subject was very afraid of the occurrence of hypoglycemia because she experienced severe hypoglycemia repeatedly. Therefore, we decided not to perform insulin tolerance test in this subject. The GH releasing hormone + arginine (GHRH + ARG) test is the best method to accurately evaluate GH secretion. However, according to the Japanese guideline for adult GH deficiency (The hypothalamic-pituitary dysfunction study group ...
Context: The impact of long-term GH replacement on cerebrovascular and cardiovascular diseases and diabetes mellitus in hypopituitary patients is unknown. Objective: The incidence of nonfatal stroke and cardiac events, and prevalence of type 2 diabetes mellitus (T2D) and cardioprotective medication were compared between cohorts of GH-deficient (GHD) patients and population controls. Design and Participants: The incidence of nonfatal stroke and cardiac events was estimated retrospectively from questionnaires in 750 GHD patients and 2314 matched population controls. A prevalence of T2D and cardioprotective medication was recorded at the distribution of questionnaires. Time since first pituitary deficiency to start of GH therapy was 4 and 2 yr, and time on GH therapy was 6 yr for GHD women and men, respectively. Results: Lifelong incidence of nonfatal stroke was tripled in GHD women and doubled in GHD men, but a decline was seen in both genders during periods after first pituitary hormone ...
Pituitary deficiency: Find the most comprehensive real-world symptom and treatment data on pituitary deficiency at PatientsLikeMe. 122 patients with pituitary deficiency experience fatigue, depressed mood, anxious mood, pain, and insomnia and use Human Growth Hormone, Amitriptyline, Bioidentical hormones, Clomiphene, and Cortisone to treat their pituitary deficiency and its symptoms.
article{01b731d3-c588-4a6e-b4b4-f23036b68aea, abstract = {Objective: GH and IGFs have mitogenic properties, causing speculation that GH treatment could increase risk of malignancy. While studies in GH-treated childhood cancer survivors have suggested a slight increase in second neoplasms, studies in GH-treated adults have been equivocal. Design: Incidence of de novo and second cancers was evaluated in 6840 GH-treated and 940 non GH-treated adult patients in the Hypopituitary Control and Complications Study pharmacoepidemiological database. Methods: Evident cancer cases were evaluated in the main analysis, with sensitivity analyses including probable and possible cancers. Standardized incidence ratios (SIRs) for cancers were calculated using Surveillance, Epidemiology and End Results for the USA and GLOBOCAN for all other countries. Results: During the mean follow-up of 3.7 years/GH-treated patient, 142 evident cancer cases were identified, giving an overall SIR of 0.88 (95% confidence interval ...
Purpose: It is essential to identify hypopituitarism in children with optic nerve hypoplasia (ONH) because they are at risk for developmental delay, seizures, or death. The purpose of this study is to determine the reliability of neurohypophyseal abnormalities on magnetic resonance imaging (MRI) for the detection of hypopituitarism in children with ONH.Design: Cross-sectional study.Participants: One hundred one children with clinical ONH who underwent MRI of the brain and orbits and a detailed pediatric endocrinologic evaluation.Methods: Magnetic resonance imaging studies were performed on 1.5-Tesla scanners. The imaging protocol included sagittal T1-weighted images, axial fast fluid-attenuated inversion-recovery/T2-weighted images, and diffusion-weighted images of (Read more...) Full Story →. ...
Pituitary infarction is a well-known consequence of postpartum hemorrhage and attendant hypotension (Sheehans syndrome). Antepartum pituitary necrosis, however, is exceedingly rare, having been reported in only four women, all young diabetics. The clinical findings and laboratory data for three additional subjects who developed acute pituitary insufficiency during the latter part of pregnancy are reported. None experienced pre- or post-partum hemorrhage or hypotension, and all delivered viable, healthy babies. After delivery all women were amenorrheic, developed cold intolerance, and had either absent or inadequate lactation. Laboratory studies showed diminished levels of plasma growth hormone, luteinizing hormone, and follicle-stimulating hormone in all three subjects; in two there was a decreased radioactive iodine uptake and diminished base-line 17-hydroxysteroids and 17-ketosteroids. On replacement therapy the three women have remained in relatively good health for 8 to 15 years after ...
Do You Have Corpus Callosum Dysgenesis Hypopituitarism? Join friendly people sharing true stories in the I Have Corpus Callosum Dysgenesis Hypopituitarism group. Find support forums, advice and chat with groups who share this life experience. A Corpu...
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CASTRO, Laura Cecilia et al. Pituitary stalk interruption syndrome: Clinical, biochemical and neuroradiological relationships. Rev. argent. endocrinol. metab. [online]. 2017, vol.54, n.4, pp.151-159. ISSN 1851-3034.. Pituitary stalk interruption syndrome (PSIS) is characterised by the combination of an interrupted or thin pituitary stalk, absent or ectopic posterior pituitary, and anterior pituitary hypoplasia. It is manifested as isolated (IGHD) or combined pituitary hormone deficiencies (CPHD) of variable degrees and timing of onset, with a wide spectrum of clinical phenotypes. PSIS may be an isolated morphological abnormality or be part of a syndrome. A retrospective evaluation is presented of clinical signs and symptoms present at early life stages, as well as an analysis of their relationship with hormone laboratory tests and diagnostic imaging in children with congenital hypopituitarism (CHP), and PSIS. This study was performed in a single centre on a sample of 42 children out of a total ...
giving birth gave me sheehan syndrome and brain damage to my pituitary gland. This was due to a lack of oxygen when losing blood after my child was born.
Causes of pituitary insufficiency include pituitary adenomas or other intrasellar and parasellar tumors, inflammatory and infectious destruction, surgical removal, radiation-induced destruction of pituitary tissue, traumatic brain injury (TBI), subarachnoid hemorrhage, and postpartum pituitary necrosis (Sheehan syndrome). Pituitary tumors, ...
Hypopituitarism, also known as an underactive pituitary gland, is a condition that affects the anterior lobe of the pituitary gland, in which the pituitary gland does not produce normal amounts of some or all of its hormones. Symptoms of hypopituitarism vary depending on which hormone is no longer being produced by the pituitary gland.. Treatments for hypopituitarism also vary. If the condition is caused as the result of a pituitary tumor, surgery may be needed for treatment. In some cases, hormone therapy is whats needed to effectively treat hypopituitarism.. However, in the November 2011 issue of Nature, a new report shows promise for the future of hypopituitarism treatment. Japanese scientists successfully treated hypopituitary mice by transplanting pituitary gland tissue they grew from embryonic mice stem cells. After the hypopitiutary mice received the transplanted cells, they began to produce hormones they were previously missing.. Researchers used the mouse stem cells arranged in a three ...
Also called an underactive pituitary gland. A condition that affects the anterior lobe of the pituitary gland, usually resulting in a partial or complete loss of functioning of that lobe. The resulting symptoms depend on which hormones are no longer being produced by the gland. Effects of hypopituitarism may be gradual or sudden and dramatic.
To characterize the extent of the hypopituitarism, appropriate testing for all clinically relevant pituitary hormones needs to be undertaken. Growth Hormone is the most commonly affected pituitary hormone in childhood hypopituitarism. Thus, the initial clue to the diagnosis of hypopituitarism is almost always short stature and slow growth, testing for which then confirms the diagnosis of Growth Hormone deficiency and begins the process of investigation for other hormonal deficiencies.. Deficiency of TSH causes central hypothyroidism (thyroid hormone deficiency). Unlike children whose hypothyroidism is due to thyroid gland damage, those with hypopituitarism typically have somewhat higher thyroid hormone levels and, thus, may have little or no symptoms, but sometimes present, like those patients with primary thyroid disease, with short stature and slow height velocity, relative weight excess, constipation, dry skin, and fatigue. A low total and/or free thyroxine (T4) level with a normal or low TSH ...
the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. If there is decreased secretion of most pituitary hormones, the term panhypopituitarism is used. The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of…
Severe prenatal deficiency of GH, as occurs in congenital hypopituitarism, has little effect on fetal growth. However, prenatal and congenital deficiency can reduce the size of a males penis, especially when gonadotropins are also deficient. Besides micropenis in males, additional consequences of severe deficiency in the first days of life can include hypoglycemia and exaggerated jaundice (both direct and indirect hyperbilirubinemia). Even congenital GH deficiency does not usually impair length growth until after the first few months of life. From late in the first year until mid teens, poor growth and/or shortness is the hallmark of childhood GH deficiency. Growth is not as severely affected in GH deficiency as in untreated hypothyroidism, but growth at about half the usual velocity for age is typical. It tends to be accompanied by delayed physical maturation so that bone maturation and puberty may be several years delayed. When severe GH deficiency is present from birth and never treated, ...
Bhasin S, Cunningham GR, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006;91(6):1995-2010. Hypopituitarism in children. Stanford Childrens Health website. Available at: http://www.stanfordchildrens.org/en/topic/default?id=hypopituitarism-in-children-90-P01962. Accessed March 6, 2018. Randeva HS, Schoebel J, et al. Classical pituitary apoplexy: clinical features, management and outcome. Clin Endocrinol (Oxf). 1999;51(2):181-188. Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, Stalla GK, Ghigo E. Hypopituitarism. Lancet. 2007;269(9571):1461-1470. Toogood AA, Stewart PM. Hypopituitarism: clinical features, diagnosis, and management. Endocrinol Metab Clin North Am. 1998;37(1):235-261 What is a growth disorder? Nemours Kids Health website. Available at: http://kidshealth.org/parent/medical/endocrine/growth%5Fdisorder.html. Updated July 2014. Accessed March 6, 2018. ...
Hypopituitarism refers to decreased secretion of pituitary hormones, which can result from diseases of the pituitary gland or from diseases of the hypothalamus. These cause diminished secretion of hypothalamic-releasing hormones, thereby reducing sec
Hypopituitarism is a partial or complete insufficiency of pituitary hormone secretion that may derive from pituitary or hypothalamic disease. The onset can be at any time of life.
The pituitary gland is in the brain. It produces several important hormones that control the production of other hormones made by glands in the body. The pituitary gland is responsible for many body functions, including the following: Hypopituitarism is an insufficient production of one or more hormones. A problem in the pituitary can cause the amount of hormones from other glands to diminish as well.
In this video exclusive, Maria Fleseriu, MD, professor of neurological surgery and professor of medicine in the division of endocrinology, diabetes and clinical nutrition in the School of Medicine at Oregon Health & Science University and director of the OHSU Northwest Pituitary Center, discusses management of hypopituitarism during pregnancy and an upcoming study of effects of growth…
Sheehans syndrome - Comprehensive overview covers signs and symptoms, causes, treatment of this rare complication of postpartum hemorrhage.
Three women in late middle age had recurrent episodes of confusion which could not be explained solely on the basis of an associated infection. All three patients had latent hypopituitarism diagnosed on final presentation. Each patient had a previous history of a severe postpartum haemorrhage followed by two further pregnancies. Experienced clinicians had not made a diagnosis of confusional episodes due to hypopituitary encephalopathy because the history was not immediately available in the confused patient, and the significance of deficient axillary and pubic hair was not given due emphasis.. ...
Author: Kilimann, I. et al.; Genre: Journal Article; Published in Print: 2007-02; Title: Change in quality of live after substitution of testosterone in patient with biaxial hypopituitarism seven years after TBI
Familial hypopituitarism information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Learn more about Hypopituitarism research and clinical trials from experts at Boston Childrens, ranked best Childrens Hospital by US News.
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Care guide for Hypopituitarism (Discharge Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Relief is when you and the right researcher find each other Finding the right clinical trial for Familial Hypopituitarism can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
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Hypopituitarism is a rare presentation of Burkitts lymphoma (BL). The purpose of this report is to present a case of BL presenting with panhypopituitarism and to review other case reports of lymphoma presenting with pituitary dysfunction to highlight the distinguishing features of these cases from other benign aetiologies of pituitary dysfunction such as non-functioning pituitary adenomas. We reviewed a total of 11 cases of lymphoma presenting with pituitary dysfunction published from 1998 to 2013 including the present case. The demographics, clinical presentations, laboratory features, radiological findings, histological diagnosis, treatment administered and outcomes were described. Of the total number of patients, 45.5% of the cases had diffuse large B-cell lymphoma while 27.3% had BL. Anterior pituitary dysfunction was more common than posterior pituitary dysfunction at presentation. The other common associated presenting symptoms were painful ophthalmoplegia, cranial nerve palsies and ...
Hypopituitarism is a rare presentation of Burkitts lymphoma (BL). The purpose of this report is to present a case of BL presenting with panhypopituitarism and to review other case reports of lymphoma presenting with pituitary dysfunction to highlight the distinguishing features of these cases from other benign aetiologies of pituitary dysfunction such as non-functioning pituitary adenomas. We reviewed a total of 11 cases of lymphoma presenting with pituitary dysfunction published from 1998 to 2013 including the present case. The demographics, clinical presentations, laboratory features, radiological findings, histological diagnosis, treatment administered and outcomes were described. Of the total number of patients, 45.5% of the cases had diffuse large B-cell lymphoma while 27.3% had BL. Anterior pituitary dysfunction was more common than posterior pituitary dysfunction at presentation. The other common associated presenting symptoms were painful ophthalmoplegia, cranial nerve palsies and ...
The prevalence of hypopituitarism after combat-related traumatic brain injury (TBI) is currently unknown. Recent civilian data on TBI show the prevalence of any pituitary hormone deficiency is as high as 80% after 12 months. While the military prevalence of hypopituitarism can be extrapolated from civilian data, a major limitation is the notably different mechanism of injury (i.e., blast) for military personnel compared to civilians (i.e., assaults, traffic accidents and falls). Little is known about the effect of shockwaves from a blast injury on central nervous system tissue, and due to the unique nature of blast-related TBI, the prevalence of pituitary dysfunction in affected service members may significantly differ from nonmilitary subjects in prior studies ...
Northwest Film Forum, that bastion of independent cinema and community engagement through film on Capitol Hill, recently enjoyed one of the most successful fundraising seasons in its 21-year history. Its upswinging popularity is due in no small part to the vision of Courtney Sheehan, who arrived at NWFF in 2013 as program director and took over the role of executive director in May of last year. Since the beginning of her tenure, Sheehan has pushed the nonprofit in new and interesting directions, vastly increasing the number of live and mixed-media events in the Film Forums two theater spaces and consistently focusing on equity and advocacy in its programming. In recognition of her work, last week Sheehan was bestowed with the award for Arts & Innovation at last Thursdays 2017 Mayors Arts Awards. We spoke with her about her take on the award, her expectations of the next mayor and the exchange between the arts and civic life.. City Arts: Congrats, Courtney, on not only winning the award but ...
BACKGROUND: Partial GH deficiency (GHD) in adults is poorly studied. OBJECTIVE: The objective of the study was to investigate the natural history and clinical implications of partial GHD. STUDY DESIGN: This was an analytical, observational, prospective, case-control study. PATIENTS: Twenty-seven hypopituitary patients (15 women, ages 20-60 yr) and 27 controls participated in the study. MAIN OUTCOME MEASURES: Measures included GH peak after GHRH plus arginine [(GHRH+ARG), measured by immunoradiometric assay]; IGF-I (measured after ethanol extraction) z-sd score (SDS); glucose, insulin, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride levels; and common carotid arteries intima-media thickness (IMT) measured periodically. RESULTS: At study entry, partial GHD patients had significantly lower IGF-I and HDL-cholesterol levels and homeostasis model assessment index than controls. During the 60 months of median follow-up, 11 patients had severe GHD (40.7%), seven ...
Siobhans parents are advocates for not just their own daughter, but for other children with Panhypopituitarism. The word Panhypopituitarism. is daunting enough to read or say - but living with this complicated condition can be even harder. Siobhans dedicated parents, along with other parents, helped define a definition of the disease for a national organization for parents of children with growth related disorders. Simply put, panhypopituitarism means that s childs pituitary gland does not function properly and as a result, the child is deficient in hormones made by the pituitary. Some children have congenital panhypopituitarism, meaning they are born with it. Others have acquired panhypopituitarism following an event such as head trauma, brain tumor surgery, or brain radiation. Unfortunately the condition cannot be cured or reversed, but again, it can be effectively managed ...
Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of ...
Definition of the syndrome [Sheehan] syndrome de Sheehan: is an imbalance in the hormonal secretions pituitary (located at the base of the brain) and in particular of its part of procedure. Syndrome Sheehan to see the lack of blood circulation during childbirth, bleeding open (the last phase of birth). Hypothyroidism Revolution Review Tom Brimeyer - According drenched 25-30 gm of them in a liter of water to treat indigestion to remove the smell of the mouth: crushed 50 grams of coriander with 40 gm candy and ISV of the powder teaspoon after All Hour with drink a little water beyond. This bleeding is due to a severe drop in blood pressure, high blood pressure is likely to cause a reduction in the proportion of oxygen at the level of the pituitary gland, pituitary gland, which causes the reduction of the arena in the hormonal secretions of the pituitary gland pituitary gland. No notes syndrome Sheehan almost the countrys evolving, it is due to follow up a bad case of pregnancy and childbirth. ...
Abstract Progressive pituitary hormone deficiency is characteristic of aging, and the hypothalamic-GH-IGF-I axis is the first hormonal system affected. Daily GH secretion peaks around puberty, begins to decline by age 21, and by age 60, most adults have total 24-hour GH secretion rates indistinguishable from those of hypopituitary patients with organic lesions in the pituitary […]. ...
The following is excerpted from a speech given by Daniel Ellsberg at a press conference where Cindy Sheehan announced her candidacy for the 8th Congressional District of California.. I see this campaign as aiming much higher than putting Cindy Sheehan in Congress in 2009. Well before that time, we aim to help restore our Constitution, to end a war and avert starting a new one, and to remove from power two officials â€" George W. Bush and Richard Cheney â€" who block those objectives before they can do more harm in their remaining months in office.. Thats an ambitious project; but theres a clear path to achieving it. We will work to change public awareness and, as a result, Nancy Pelosis policies as Speaker of the House well before the election, by revealing to the public real alternatives to the courses she and the Democrats have followed so far, and demonstrating the breadth and strength of public support for those alternatives.. The truth is that Democrats, and even Republicans, can ...