To understand better the relationship between hypothalamic galaninergic neurons and the pituitary gland, we studied the effects of hypophysectomy on hypothalamic galanin (GAL) content and distribution by radioimmunoassay and immunohistochemistry, and on GAL mRNA by Northern blot analysis. Three weeks after hypophysectomy, performed at 5 or 8 weeks of age, the hypothalamic concentrations of GAL and GAL mRNA were reduced by 30-50% in both male and female rats, compared to age- and sex-matched controls. Similar reverse-phase HPLC retention times of hypothalamic GAL were observed in intact and hypophysectomized rats. The reduction of hypothalamic GAL concentration following hypophysectomy was time-dependent, as peptide levels were unaffected one week after surgery. Immunohistochemistry showed regional differences in the effect of hypophysectomy on galaninergic neurons. In the hypophysiotropic hypothalamus, the scarce GAL immunoreactivity normally observed in the arcuate nuclei was no longer ...
Looking for hypophysectomy? Find out information about hypophysectomy. Surgical removal of the pituitary gland Explanation of hypophysectomy
The pituitary gland has been found to be an important factor in mammary development in primates. Hypophysectomy in 12 sexually immature monkeys caused significant inhibition of estradiol (E2)-induced mammary growth and development. A histological index of mammary development in sexually immature hypophysectomized animals was lower (0.82) than in intact E2-treated controls (3.4; P less than 0.008). Hypophysectomy also inhibited growth of the mammary gland as judged by a size index. Despite the hypophysectomy, E2 stimulated some, albeit blunted, mammary growth and development, which may have been due to incomplete hypophysectomy. Selective inhibition of prolactin by ergot drugs in intact animals did not prevent full mammary development, suggesting that there may be pituitary mammogens other than prolactin, or that very low or unmeasurable concentrations of prolactin were sufficient to synergize with E2 to cause full acinar development. The mean histological index was 3.08 in E2-treated animals and ...
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The mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.
Objectif : létude prospective de 23 cas dhypophysectomie transseptale-transsphénoïdale souligne les aspects rhinologiques de cette technique
The effects of the plasma pattern of GH on serum and lipoprotein levels of total cholesterol, triglycerides, apolipoprotein A-I (apo A-I), apolipoprotein B 48/100 (apo B), and apolipoprotein E (apo E) were studied in hypophysectomized female Sprague-
In a detailed description of the 17 cases, Scott and Schirmer arrived at the following conclusions. While the intention of hypophysectomy was palliative (i.e. not intended to extend life), it could not be demonstrated to improve survival outcomes of these patients. Instead Scott and Schimer recognized that grade, timing of metastases and castration had the largest influence on survival times. While hypophysectomy could improve the subjective (symptoms) and objective (lab values) progression of many of these patients, they recognized that ...
A technique that permitted the reversible dissociation of rat liver ribosomes was used to study the difference in protein-synthetic activity between liver ribosomes of normal and hypophysectomized rats. Ribosomal subunits of sedimentation coefficients 38S and 58S were produced from ferritin-free ribosomes by treatment with 0.8m-KCl at 30°C. These recombined to give 76S monomers, which were as active as untreated ribosomes in incorporating phenylalanine in the presence of poly(U). Subunits from normal and hypophysectomized rats were recombined in all possible combinations and the ability of the hybrid ribosomes to catalyse polyphenylalanine synthesis was measured. The results show that the defect in ribosomes of hypophysectomized rats lies only in the small ribosomal subunit. The 40S but not the 60S subunit of rat liver ribosomes bound poly(U). The only requirement for the reaction was Mg2+, the optimum concentration of which was 5mm. No apparent difference was seen between the poly(U)-binding ...
Background: Pituitary hormones play an important role in bone growth, modeling, and remodeling. The purpose of this study is to examine the effect of hypophysectomy (HX) on tibial cortical bone with histomorphometry.. Methods: Forty-Five female Sprague-Dawiey rats, at 3 months of age, were hypophysectomized or served as intact controls. They were sacrificed at 0, 2, and 5 weeks after the surgery. Cortical bone histomorphometry was performed on double-fluorescent-labeled 30-mcm-thick sections of the tibial shaft.. Results: The dry weight and density of tibial diaphysis and the cortical bone area of the tibial shaft in the HX rats were significantly lower (P,0.05) than that of the age-matched intact rats, but did not differ between the HX and basal control rats. The dynamic data show that the bone formation parameters (labeled surface, mineral apposition rate, and bone formation rate) were profoundly decreased (P,0.01) on both the periosteal and endocortical surfaces in the HX rats as compared ...
TY - JOUR. T1 - Structural changes in the proximal tubule of kidneys from hypophysectomized rats.. AU - Evan, Andrew. AU - Simone, P. G.. AU - Solomon, S.. AU - Loker, E. F.. PY - 1972/10. Y1 - 1972/10. UR - http://www.scopus.com/inward/record.url?scp=0015414239&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0015414239&partnerID=8YFLogxK. M3 - Article. C2 - 5077377. AN - SCOPUS:0015414239. VL - 174. SP - 265. EP - 277. JO - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. JF - Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. SN - 0003-276X. IS - 2. ER - ...
In investigating the feedback effects of circulating hormones on the brain, we showed previously that adrenalectomy (ADX) increases vasoactive intestinal peptide (VIP)-stimulated cAMP generation in slices from rat hippocampus, a brain structure with high levels of glucocorticoid receptors. This effect is reversed by replacement with glucocorticoids such as dexamethasone (DEX) and corticosterone (CORT). Here we report that, like ADX, hypophysectomy (HYPOX) also elevates VIP- stimulated cAMP generation, compared with sham-operated controls. Moreover, like glucocorticoid replacement, administration of ACTH to HYPOX rats causes a decrease in cAMP stimulation by VIP. Furthermore, ACTH had no effect when given to HYPOX + ADX rats, indicating that the effects of ACTH require the presence of adrenal steroid secretion. However, we find that ACTH may have a permissive role in this glucocorticoid effect because, in the absence of the pituitary, DEX treatment does not decrease VIP-stimulated cAMP levels in ...
Five groups of five lactating rabbits each were used. Milk yield was recorded from the 8th day of lactation onwards and on the 10th day of lactation the rabbits received the following treatments: Group S, sham-operation with saline (1 ml/12 h); Group P, hypophysectomy with sheep prolactin (1 mg/12 h); Group H, hypophysectomy with human growth hormone (1 mg/12 h); Group B, hypophysectomy with bovine growth hormone (1 mg/12 h) and Group C, hypophysectomy with saline (1 ml/12 h). The injections of saline or hormones were continued for 5 days and at the end of this period a blood sample was taken, the animals were killed and their mammary glands removed for histological examination and assay of the following enzymes: 6-phosphogluconate dehydrogenase (EC 1.1.1.44), phosphofructokinase (EC 2.7.1.11), phosphoglucomutase (EC 2.7.5.1), UDP-glucose pyrophosphorylase (EC 2.7.7.9), acetyl-CoA carboxylase (EC 6.4.1.2), acetyl-CoA synthetase (EC 6.2.1.1) and ATP-citrate lyase (EC 4.1.3.8). On the 5th day ...
Growth hormone (GH) secretory patterns regulate the expression of several sex-dependent liver cytochrome P450 (CYP) genes. Studies using the hypophysectomized rat model have established that the intermittent plasma GH secretory pattern associated with adult male rats markedly stimulates liver expression of the male-specific CYP 2C11, a testosterone 2 alpha- and 16 alpha-hydroxylase, but is not required for expression of other male-specific liver enzymes, including CYP 2A2, a testosterone 15 alpha-hydroxylase, and CYP 3A2, a testosterone 6 beta-hydroxylase. In the present study, the effects of intermittent GH treatment on liver CYP expression were studied in adult rats rendered GH deficient by neonatal administration of monosodium glutamate (MSG), which depletes circulating adult GH without the global loss of other pituitary-dependent hormones that is associated with hypophysectomy. Restoration of the normal masculine circulating GH profile of six daily pulses (180-225 ng GH/ml/peak) in ...
The surgical removal of the hypophysis is a treatment option for growths on the pituitary gland that can lead to high blood pressure, increased sugar levels, immunosuppression, imbalanced electrolytes, and an abnormal metabolism. - Wag! (formerly Vetary)
Axlunds Pioneering Treatment for Cushings Disease by Todd Axlund, DVM, MS, ACVIM (Neurology) http://metropolitanvetreferralgroup.com/media-minutes/2008-08-MM-Newsletter.pdf
In people, TSHS to remove the tumor is the most successful long-term therapy. Surgical cure rates for people are reported to be in the range of 65-85 percent with a recurrence rate of 25 percent within five years. Hypophysectomy in dogs resulted in similar long-term remission rates. Procedural mortality rate associated with TSHS is approximately 8-20 percent and incomplete hypophysectomy occurs in about 6 percent of the cases. Two primary limiting factors to widespread use of TSHS and subsequent successful surgery are: (1) difficulty in accurately defining the bony borders of the sella turcica based on anatomic landmarks alone; and (2) difficulty in visualizing the surgical site because of poor illumination and magnification. A high-definition telescope system (VITOMTM, Karl Storz Endoscopy, Tuttlingen, Germany) has been used successfully and repeatedly by human surgeons during microneurosurgeries such as craniotomies and spinal surgery. The VITOMTM functions like a microscope and has improved ...
2-4 h nach Hypophysektomie erhöht Noradrenalin den Sauerstoffverbrauch wie bei Kontrollratten, 7 Tage nach der Entfernung der Hypophyse ist jedoch diese Wirkung des Noradrenalin aufgehoben. Die CO2-Ab...
Bei 31 Patienten mit akutem Myokardinfarkt im Alter von 36-76 Jahren wurden arterielle Blutgase, pH und Standardbicarbonat bestimmt. Bei 18 von diesen 31 Patienten liegen die gleichen Meßwerte unter...
A study was made of the optimal conditions for the induction of mammary cancer in the rat. 3-Methylcholanthrene was administered via the gastrointestinal tract, and a simple technique was worked out for inducing mammary cancer regularly and rapidly. Under conducive conditions, which were readily reproduced, multiple mammary carcinomas and these tumors only were induced in every rat in repeated experiments in 60 days or less. In the strain of animal employed in the present experiments, the rapid induction of mammary cancer proved to be a function of (a) dosage, (b) the timing of administration of the aromatic hydrocarbon, and (c) a favoring hormonal status of the recipient.. Most of the established tumors were hormone-dependent because they diminished markedly in size after hormone withdrawal through ovariectomy or hypophysectomy. Similar regression of the tumors was frequently achieved by the administration of dihydrotestosterone. Shrinkage of the cancers was accompanied by atrophic changes. ...
The therapeutic use of human progress hormone has caused worry, as it is anabolic and mitogenic, and its effector hormone, insulin-like progress variable (IGF)-I is anti-apoptotic. As both equally hormones can result in proliferation of standard and malignant cells, the possibility that HGH therapy may possibly induce most cancers, enhance the threat of tumor recurrence in those Earlier addressed for any malignancy, or increase the danger of cancer in Those people having a predisposition, has resulted in worries around its use. Malignant tumors happen to be induced in animals exposed to supraphysiological doses of HGH, While hypophysectomy seems to shield animals from carcinogen-induced neoplasms. In vitro, proliferation and transformation of typical haemopoetic and leukemic cells happens with supraphysiological doses of HGH, but not with physiological degrees. IGF, IGF binding proteins (IGFBP) and IGFBP proteases impact the proliferation of most cancers cells in vitro; nevertheless, HGH is ...
Metabolická acidóza je stav zvýšenej tvorby metabolických kyselín, zvyčajne v dôsledku narušenia schopnosti vylučovania kyselín prostredníctvom obličiek. Renálna acidóza je spojená s kumuláciou močoviny, kreatinínu a iných produktov rozkladu bielkovín. Zvýšená tvorba iných kyselín môže tiež vyvolať metabolickú acidózu. Napríklad kyselina mliečna môže vyvolať acidózu napr. pri ťažkej hypoxémii (tlak O2 v krvi pod 36 mm Hg) ktorá vyvolá znížený prienik kyslíka do tkanív, alebo pri hypoperfúzii (napr. pri šoku) kde dochádza k nedostatočnému prekrveniu tkanív. Ak koncentrácia kyseliny mliečnej rastie bez zodpovedajúceho nárastu pyruvátu, môže poukazovať na anaeróbny metabolizmus vo svaloch s akým sa stretávame aj pri namáhavom cvičení. Po obnovení dodavky kyslíka acidóza rýchlo ustúpi. Ďalší stav zvýšenej tvorby kyselín v tele sa vyskytuje pri hladovaní a diabetickej acidóze. Je spôsobený kumuláciou ketokyselín ...
Pituitary macroadenomas are the most common suprasellar mass in adults, and responsible for the majority of transsphenoidal hypophysectomy. They are defined as pituitary adenomas greater than 10 mm in size and are approximately twice as common as...
Adrenal venous blood was collected from hypophysectomized and sham-hypophysectomized dogs 6 days postoperatively. 17-Hydroxycorticosterone, corticosterone, 11-desoxy-17-hydroxycorticosterone and aldosterone were isolated by paper chromatography. Histological examination of the sellar and suprasellar regions of the hypophysectomized dogs demonstrated the absence of pituitary tissue. The adrenal glands of the hypophysectomized dogs showed cortical atrophy which did not involve the zona glomerulosa. The rate of secretion of aldosterone by the hypophysectomized dogs was found to be approximately 66% of that of the control, sham hypophysectomized, dogs. The rates of secretion of 17-hydroxycorticosterone, corticosterone and 11-desoxy-17-hydroxycorticosterone were found to be approximately 10% of that of the controls. The ability of the hypophysectomized dog to remain in electrolyte balance appears to be due in large measure to the continued secretion of aldosterone.. ...
Erythropoietic activity of foetal rat femoral marrow was examined during the last four days of intra-uterine life. Insignificant at day 18, it develops slowly thereafter until birth. In the non-suckled neonate (not older than two hours), it appears notably enhanced. In order to test the potential of the foetal marrow to develop precocious or increased erythropoiesis, the activity of the erythropoietic organ predominant at this time, the liver, was altered by modifying the level of circulating corticosteroids which govern its function. Maturation and involution of the hepatic erythron were prevented by corticosteroid deprivation of the foetus (maternal adrenalectomy and foetal hypophysectomy). Precocious maturation and exhaustion of the hepatic erythron was induced by submitting foetuses to corticosteroids excess from day 14. Both corticosteroid deprivation and excess increase the erythropoietic activity of the femoral marrow. This activity can reach and even exceed by day 20 of intrauterine life ...
#gasclass is back for term 6We have had a great holiday and the team has been conferring for some new cases and appointing a new member for the team.This week we are starting off in theatre reception and your list has a trans-sphenoidal hypophysectomy.In classic #gasclass questioning style tell us on Twitter what you are…
Much time and effort have been spent in the study of the probably complex interrelationship existing between the anterior pituitary and the pancreatic islets in their regulation of carbohydrate metabolism. Many points are still obscure. However, there is evidence for an over-all antagonistic action between the hypophysis and the islets of Langerhans which is well supported by the following data.. Hypophysectomy results in a marked improvement in the diabetic state of depancreatized animals,1, 2 and permanent diabetes can be induced by injecting extracts from the anterior pituitary.3, 4, 5, 6, 7 These facts indicate that a diabetogenic principle is formed ...
All answers except for D are examples of atrophy. Atrophy of skeletal muscles can result from a loss of innervation due to spinal cord or peripheral nerve trauma. Inactivity, as is often seen following the long-term immobilization of an extremity in a cast, has the same effect. Hypophysectomy is accompanied by atrophy of the thyroid, adrenal cortex, and ovary, which are all organs that depend on stimulation by pituitary trophic hormones. The brain atrophies with advancing age. Estrogen exerts trophic effects on the endometrium, causing hyperplasia rather than atrophy.Endometrial atrophy occurs following ovariectomy or after the menopause, when the ovaries no longer produce estrogen. ...
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The effects of hypophysectomy and prolactin-suppressing drugs on the growth of mammary tumors induced in Sprague-Dawley rats by N-nitrosomethylurea and dimethylbenz(a)anthracene were compared. The influence of ovine prolactin and growth hormone administration on N-nitrosomethylurea-induced tumors was also studied in hypophysectomized animals. After hypophysectomy, all 13 tumors induced in 13 rats by N-nitrosomethylurea underwent regression, as did ten of 12 induced by dimethylbenz(a)anthracene. There were no new tumors. Pergolide mesylate, a long-acting ergoline derivative, was given in a dose of 80 μg twice daily by s.c. injection for 28 days. Only three of 12 N-nitrosomethylurea-induced tumors regressed, while four became static. However, only two new tumors developed in the 12 pergolide-treated rats, compared to 11 in the 12 untreated controls. Bromocriptine mesylate, at ten times the pergolide dose, was even less effective; one of 16 tumors regressed, two became static, and eight new tumors ...
Since the work of Watson & Pearce (1949) it has been known that subnormal thyroid activity affects the glycosaminoglycans (GAG) of skin. The changes reported were an increase in the hyaluronic acid and a decrease in the dermatan sulphate content of the skin (Schiller, Slover & Dorfman, 1962; Kofoed & Bozzini, 1967). These results seem to be independent of thyrotrophin because the same changes are noted after hypophysectomy as in hypothyroidism (Schiller et al. 1962). Since hypophysectomy has a different effect on skin and tracheal cartilage GAG (Kofoed & Bozzini, 1969), experiments were done to study the distribution of these compounds in cartilage of thyroidectomized rats and to compare this with the distribution in skin.. Female Wistar rats, weighing approx. 200 g., were used throughout these experiments. Thyroid destruction was accomplished by administration of 700 μc of 131I. Six months after radioactive iodine administration, rats were divided into three ...
In hypophysectomized and thyroidectomized rats, cytosolic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase activity, immunoreactive protein and mRNA levels were all considerably decreased. Administration of L-tri-iodothyronine (T3) resulted in a large increase in all three in hypophysectomized rats and in only a 2-fold increase (reaching the values of control rats) in thyroidectomized rats. ...
Bartke, A, "Effects of prolactin and luteinizing hormone on the cholesterol stores in the mouse testis." (1971). Subject Strain Bibliography 1971. 2423 ...
References:. Arwert LI, Deijen JB and Drent ML. Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-1 secretion in middle-aged and elderly subjects. Nutr. Neurosci. 2003 Oct;6(5):269-75.. Biolo G, Tipton KD, Klein S and Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. 1997 Jul;273(1 Pt 1):E122-9.. Chen LW, Wang YQ, Wei LC, Shi M and Chan YS. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinsons disease. CNS Neurol. Disord. Drug Targets 2007 Aug;6(4):273-81. Chen MM, Yeh JK and Aloia JF. Histologic evidence: growth hormone completely prevents reduction in cortical bone gain and partially prevents cancellous osteopenia in the tibia of hypophysectomized rats. The Anatomical Record (1997) 249:163-72.. Chromiak JA and Antonio J. Use of amino acids as growth hormone-releasing agents by athletes. Nutritrion 2002 ...
Dr. Geoffrey Sher established the first private IVF Center in the US in 1982. For over 30 years he has been advocate for womens reproductive health concerns while trailblazing medical breakthroughs.
1-(Morpholinomethyl)-4-phthalimido-piperidindione-2,6 (CG 603) had a greater therapeutic effect than bilateral ovariectomy, estrogen (mestranol, 17α-ethinylestradiol-3-methylether), or androgen (drostanolone propionate, 2α-methyldihydrotestosterone propionate, 2α-MDTP) on 7,12-dimethylbenzanthracene-induced tumors in Sprague-Dawley rats. The antitumor activity of CG 603 was equivalent to hypophysectomy. Combined treatment with CG 603 and ovariectomy or estrogen gave no significant increase in antitumor activity over that with CG 603 alone. The combined treatment with CG 603 and 2α-MDTP showed a significantly higher regression of tumor weight and tumor number than the treatment with CG 603 or 2α-MDTP alone. While CG 603 in higher concentrations decreases the body weight of experimental animals, the combination of CG 603 in lower concentration with the anabolically acting 2α-MDTP increases the body weight of the treated animals. CG 603 probably exerts its antitumor activity primarily via ...
An East Texas brain tumor patient is recovering from the operation. Its called endoscopic transphenoidal hypophysectomy, where .... In laymens terms tumor was removed through the nasal cavity. A neurosurgeon from Mother Frances Hospital in Tyler is the first and only doctor in the region who can perform the operation. "It was purely endoscopic. We did not have to remove any bone or tissue within the nerves of the mouth. So were able to prevent an invasive approach," says Sabatino Bianco, MD. The Neuroscience Institute Director for Trinity Mother Frances Health System performed the surgery.. Advantages of this kind of surgery: most patients are released within one or two days and facial swelling and pain are eliminated or reduced. Christine Nelson, Reporting [email protected] ...
The purpose of this study was to determine whether recombinant human growth hormone (rhGH) would show any significant effects on the expression of apoptosis regulating proteins in peripheral blood mononuclear cells (PBMCs). Additionally, the potential for post-transcriptional regulation of gene expression by miRNA was assessed in two cellular compartments, the cytosol and the mitochondria. Ten male subjects were subcutaneously injected with either rhGH (1 mg) or saline (0.9%) for seven consecutive days in a double-blinded fashion. Blood sampling was undertaken prior to treatment administration and over a period of three weeks following treatment cessation. Bcl-2 and Bak gene and protein expression levels were measured in PBMCs, while attention was also directed to the expression of miR-181a and miR-125b, known translational inhibitors of Bcl-2 and Bak respectively. Results showed that rhGH significantly decreased Bak protein concentrations compared to placebo samples for up to 8 days post treatment.
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by Guest Author , Sep 11, 2016 , Beauty. All of us probably know the effects of growth hormone on our body. It is very important for muscle growth, fat metabolism and growth of bones. Its secretion is increased during teenage and adolescence, when there is a growth spurt in the body. Many people believe that ...
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Somatotropin treatment in chronically hypophysectomized, sodium-deprived rats effectively restored to treated animals the distinct and enhanced aldosterone secretory responsiveness of the adrenal which characterizes the adrenals of intact rats subjected to dietary sodium restriction, but absent in chronic and nontreated, adenohypophysectomized or totally hypophysectomized rats subjected to similar conditions of ... read more dietary sodium restriction. Treatment with β1−24ACTH(Zn) alone was ineffective, albeit adrenal weight and glucocorticoid secretory responsiveness were effectively maintained. The observed efficacious effect of somatotropin is similar and indistinguishable from the previously demonstrated effect produced by treatment of anterior pituitary powder in chronically hypophysectomized, sodium-deprived rats. The earlier findings that somatotropin is without any direct or specific stimulatory effect on aldosterone secretion and that treatment of intact, sodium-repleted rats with ...
ADVANCES IN THE MANIPULATION OF PIG GROWTH INTERACTIONS BETWEEN PORCINE GROWTH HORMONE ADMINISTRATION AND DIETARY PROTEIN R. G. CAMPBELL, R. J. JOHNSON, R. H. KING AND M. R. TAVERNER SUMMARY Two experiments involving a total of 132 entire male pigs were conducted to investigate the interrelationships between exogenous porcine growth hormone (pGH) administration (0 and 0.09mg recombinant pGH/kg/d) and dietary ideal protein levels ranging from 83 to 238 and 70 to 238g/kg on the performance and carcass composition of pigs growing from 30 to 60kg (Experiment 1) and 60 to 90kg (Experiment 2) respectively. Growth rate and feed:gain improved with increasing dietary ideal protein up to approximately 173 and 137g/kg in experiments 1 and 2 respectively and were enhanced by pGH administration in pigs offered the higher protein diets but unaffected or slightly depressed by pGH administration to pigs given the two lowest protein diets in each experiment. Protein deposition and plasma Insulin like growth ...
Joseph, Franklin, Ahmad, Aftab M, Ul-Haq, Mazhar, Durham, Brian H, Whittingham, Pauline, Fraser, William and Vora, Jiten P (2007) Effects of Growth Hormone Administration on Bone Mineral Metabolism, PTH Sensitivity and PTH Secretory Rhythm in Postmenopausal Women With Established Osteoporosis. Journal of Bone and Mineral Research, 23 (5). pp. 721-729. ISSN 1523-4681 Full text not available from this repository. (Request a copy ...
The possibility is explored that life first self-assembled in a hydrophobic environment in the subsurface protected from radiation with ubiquitous hydrogen as the likely universal energy source. No mutations within the coding region of exons 11, 14, 15 and the intron-exon when will generic cialis be available in the united states junctions for the remaining samples were found. The cyk-3 gene has been identified and found to encode a ubiquitin C-terminal hydrolase that is active against model substrates. The effects of human pituitary gonadotrophins on hypophysectomized rats. Here we report on the production and characterization of a monoclonal antibody (BC-1) which recognizes an epitope within the protein sequence coded for by the ED-B exon.. These are measured according to the frequency of dichotomous response of the subjects being studied. Effects of suramin on neuroendocrine and behavioural when is cialis going generic responses to conditioned fear stimuli. The mean SNR was 71.2, 25.7 and ...
Administration of triamcinolone diacetate to rats results in a decrease of prolyl hydroxylase activity in organs from animals of different ages. The response of the enzyme activity is dose-dependent, reversible, independent of endocrine function (except for the response of the liver enzyme in hypophysectomized rats), and dependent on the number of daily injections. The decrease in enzyme activity is paralleled by a decrease in the amount of enzyme protein as measured by immunoassay. These results indicate that prolyl hydroxylase is decreased in a wide spectrum of tissues following administration of anti-inflammatory steroids. Furthermore, these findings suggest that one of the effects of this class of therapeutically used drugs on connective tissue metabolism may be mediated by a decrease in the prolyl hydroxylation step of collagen biosynthesis.. ...
As the most common endocrine metabolic disorder for human beings, diabetes mellitus with an obvious phenomenon of high blood glucose concentrations results from a lack of insulin. Despite the availability of treatment, diabetes has remained a major cause of death and serious vascular and neuropathy diseases. Continuously monitoring the blood glucose level and intermittent injections of insulin are widely used for effective control and management of diabetes. Extensive research has been conducted to develop optimal glucose sensors for diagnostic purposes. Currently, the commercially available glucose biosensors still have some problems to overcome, such as time consuming, relatively low sensitivity, bad reliability. The performance of a glucose sensor is largely dependent upon the materials which construct the sensor. Recent research effort for glucose sensing have turned to on nanomaterials. Nanomaterial-based biosensors already have shown the capability of detecting trace amounts of biomolecules in
Objectives and Specific Aims:. We plan to investigate whether growth hormone, administered in a physiological or pulsatile fashion, can elicit relevant changes in the human immune system while at the same time associated with no change or even an improvement in the metabolic profiles such as insulin sensitivity.. Experimental Design and Methods:. Thirty-eight healthy men, age 25-50, will be recruited for this study. There are three parts to this study: Study I, Study IB and Study II. Study I and IB each involve six subjects and are designed to test the hypothesis that pulsatile subcutaneous infusion of GH via a subcutaneous infusion pump will yield a reasonable pulsatile GH pattern. The dose of GH used in Study IB will be three-fold higher that that in Study I. Study I and IB will be done first before proceeding to Study II.. Study II is a randomized, double-blinded, placebo-controlled 12-week study involving 26 subjects divided into 2 groups: Group A and Group B. Group A will involve 13 ...
We have studied the regulation of somatostatin (SS) and growth hormone-releasing hormone (GHRH) gene expression in the brain of the laboratory rat. We report that hypophysectomy in the adult male reduces SS mRNA in cells of the periventricular nucleus (PeN), while GH reverses this effect. We ...