BACKGROUND: Recent nutrition guidelines for extremely-low-birth-weight infants (ELBWIs) recommend implementation of high initial amino acid (AA) supplementation in parenteral nutrition.. OBJECTIVE: We sought to evaluate the influence of AA intake on refeeding syndrome-like electrolyte disturbances including hypophosphatemia in ELBWIs.. STUDY DESIGN: Medical records of 142 ELBWIs were reviewed. Demographic, nutritional, outcome, and electrolyte data were compared between ELBWIs with initial low (1.5 g/kg/day) and high (3 g/kg/day) AA intake. Multivariate analysis was conducted to determine the odds ratio of hypophosphatemia with high AA intake and small-for-gestational-age (SGA) ELBWIs.. RESULTS: The incidence of hypophosphatemia and severe hypophosphatemia increased from 51% and 8% in period I to 59% and 20% in period II, respectively (p = 0.36 and , 0.01). Specifically, SGA ELBWIs showed higher incidence of hypophosphatemia than appropriate-for-gestational age (AGA) ELBWIs in period II, whereas ...
Synonyms for electrolyte management: hypophosphatemia in Free Thesaurus. Antonyms for electrolyte management: hypophosphatemia. 38 synonyms for management: administration, control, rule, government, running, charge, care, operation, handling, direction, conduct, command, guidance.... What are synonyms for electrolyte management: hypophosphatemia?
En condiciones normales la fosfaturia 24 h es de unos mg. Lo que debe asegurarse siempre es el tratamiento de la causa subyacente. Causes of hypophosphatemia. En: Up to Date. Rose BD, ed. Wellesley, MA, Agus ZS. Diagnosis and treatment of hypophosphatemia. Molecular pathogenesis of hypophosphatemic rickets. J Clin Endocrinol Metab ; Kronenberg HM. NPT2a-the key to phosphate homeostasis.. N Engl J Med ; Prolonged high-dose phosphate treatment: a risk factor for tertiary hyperparathyroidism in X-linked hypophosphatemic rickets. Clin Endocrinol Oxf ; Barcelona: Masson; Dipyridamole decreases renal phosphate leak and augments serum phosphorus in patients with low renal phosphate threshold. J Am Soc Nephrol ; Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.. Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem. Genetic disorders of ...
Introduction: Refeeding syndrome is characterised by acute electrolyte derangement following the start of nutrition. Hypophosphataemia is the predominant feature of the electrolyte derangement, hence commonly used for its definition. We aim to assess the incidence of refeeding hypophosphataemia, and its associated risk factors, and outcome in our local ICU. Materials and Methods: This was a single centre, prospective observational study at the ICU of Hospital Tengku Ampuan Afzan Kuantan, involving adult admission longer than 48 hours. Chronic renal failure patients and those receiving dialysis were excluded. Refeeding hypophosphataemia (RH) was considered if plasma phosphate was less than 0.65 mmol/l. Results: Fifty-four patients were screened. After exclusion, 29 were recruited, of which, 13 (44.8%) patients had RH. Of this, 66% occurred with duration of fasting of less than two days. These patients had higher NUTRIC score (3.9 ± 2.1 versus 2.4 ± 1.9, p=0.05). There was a trend of lower ...
en] We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) was abnormally high and the diagnostic of tumor-induced osteomalacia was made. Despite multiple tests, the tumor was not localized. In this report, we discuss different possible investigations to localize the tumor. Lastly, we review the potential therapy available when tumor is not found and can thus not ...
In the current study we report for the first time that serum FGF21 levels are strikingly elevated in newly diagnosed type 2 diabetic patients with subclinical atherosclerosis compared to those without subclinical atherosclerosis. This observation remained true in both men and women when the results were analyzed independently. Moreover, we detected a strong association of FGF21 with carotid IMT in women as well as iliac IMT in men and women with type 2 diabetes.. Several risk factors have been proposed as potential markers for improved detection of subclinical atherosclerosis. In particular, physical measurements such as neck circumference [21] and abdominal adiposity [22]; inflammatory biomarkers such as C-reactive protein (CRP) [23]; lipid parameters such as oxidized LDL; adhesion molecules such as E-selectin; cytokines such as osteoprotegerin; and adipokines such as leptin [24], have all been associated with subclinical atherosclerosis in different ethnic groups. However, each of these ...
Oncogenic hypophostphatemic osteomalacia is rare form of osteomalacia with few cases reported in the literature. It is characterized by later onset in adulthood, renal phosphate loss with hypophosphatemia and poor bone mineralization. The syndrome is associated with mesenchymal tumours or prostatic CA. We report a case of oncogenic hypophosphatemic ostoemalacia associated with neurofibromatosis.. Key words: Oncogenic hypophoosphatemic osteomalacia, neurofibromatosis, mesenchymal tumors ...
1. A patient with familial adult-onset hypophosphataemia, whose myopathy was closely related to the plasma phosphate concentration, was investigated by phosphorus nuclear magnetic resonance spectroscopy (31P n.m.r.) in vivo of the right flexor digitorum superficialis muscle.. 2. During hypophosphataemia induced by stopping oral phosphate a significant reduction in measured muscle strength occurred, but the ratios of the intramyocellular levels of phosphocreatine (PCr), adenosine triphosphate (ATP) and inorganic phosphate (Pi) remained unchanged at rest. During exercise these levels changed, as did the intramyocellular pH, but they did not differ from the pattern previously recorded in normal subjects.. 3. In four adults with inherited infantile-onset hypophosphataemia (vitamin D-resistant rickets, VDRR) without myopathy, the n.m.r. measurements were normal at rest and during exercise.. 4. In one patient with inherited hyperphosphataemia (tumoral calcinosis) the resting PCr: Pi ratio was ...
In this prospective longitudinal cohort study we studied the efficacy and safety of burosumab in real-clinical practice for ,13- and ,13-years old children affected with X-linked hypophosphatemia.. 57 children with XLH were switched from conventional treatment to burosumab. After 12 months we assessed the efficacy and safety of treatment with burosumab on the whole cohort and separately on the cohort of ,13-years old adolescents. ...
Approach and Results-The cohort consisted of 670 subjects who underwent carotid IMT measurement. Serum FGF21 levels were measured with an ELISA kit. Serum FGF21 levels positively correlated with carotid IMT in women (r=0.32; P,0.001), but not in men (r=0.06; P=0.305). On multiple linear regression analysis, elevated serum FGF21 level in women was an independent risk factor for increased carotid IMT (P=0.039), together with age (P,0.001) and hypertension (P=0.011), in a model comprising also waist circumference, smoking history, serum creatinine, high sensitive C-reactive protein, dysglycemia, and dyslipidemia (adjusted R2=35.8%; P,0.001). Elevated serum FGF21 levels were also a significant independent risk factor of carotid IMT on multiple stepwise regression analysis (P=0.01).. ...
For many years, the existence of phosphatonins-substances secreted by certain tumors which result in profound renal phosphorus wasting and resultant osteomalacia-has been postulated.. Evidence has recently been accumulating that fibroblast growth factor 23 (FGF-23) is the phosphatonin we have been searching for:. High circulating levels of FGF23 are associated with hypophosphatemia, decreased 1,25 (OH) vitamin D levels, and rickets/bone disease.. The disease autosomal dominant hypophosphatemic rickets is caused by gain-of-function mutations in FGF23caused by splice site mutations. Conversely, the genetic disease inherited tumoral calcinosis, characterized by hyperphosphatemia, increased 1,25 (OH) vitamin D levels, and metastatic calcifications.. In ESRD, FGF23 levels are appropriately elevated in response to hyperphosphatemia, but due to a reduced GFR is unable to induce adequate phosphaturia.. How it works at a molecular level: FGF23 interacts with FGF receptors at the proximal tubule, ...
Fingerprint Dive into the research topics of Tertiary excess of fibroblast growth factor 23 and hypophosphatemia following kidney transplantation. Together they form a unique fingerprint. ...
JM Land, DJ Taylor, GJ Kemp, GK Radda, B Rajagopalan; Idiopathic Renal Hypophosphataemia: Oral Phosphate Reverses Abnormalities in Muscle. Clin Sci (Lond) 1 March 1992; 82 (s26): 26P. doi: https://doi.org/10.1042/cs082026Pa. Download citation file:. ...
Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1α-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH]2D3). PTH promotes calcium release from the bone and enhances tubular calcium resorption through direct action on these sites. Hallmarks of secondary hyperparathyroidism associated with chronic kidney disease (CKD) include increase in serum fibroblast growth factor 23 (FGF-23), reduction in renal 1,25[OH]2D3 production with a decline in its serum levels, decrease in intestinal calcium absorption, and, at later stages, hyperphosphatemia and high levels of PTH. In this paper, we aim to critically discuss severe CKD-related hyperparathyroidism, in which PTH, through calcium-dependent and -independent mechanisms, leads to harmful effects and manifestations of the uremic syndrome, such as bone loss, skin and soft tissue calcification, cardiomyopathy, immunodeficiency, impairment of erythropoiesis, increase of
Serum Fibroblast Growth Factor 19 Levels Are Decreased in Chinese Subjects With Impaired Fasting Glucose and Inversely Associated With Fasting Plasma Glucose Levels ...
Phosphaturic mesenchymal tumor (PMT) represents a rare cause of osteomalacia. The clinical signs and symptoms are vague and these lead to diagnosis delay. In the presence of hypophosphatemia and relatively high urine phosphate excretion, this entity should be taken into consideration in the deferential diagnosis of osteomalacia. In the present article, we report 81-year-old man presented to our clinic for evaluation due to osteopenia. His laboratory results disclosed hypophosphatemia, relatively increased urine phosphate excretion and increased level of intact fibroblast growth factor 23 (FGF23). A 68Gallium DOTATATE PET/CT revealed pathological uptake in the upper aspect of the left shoulder adjacent to the coracoid process. For suspected PMT a wide resection of the tumor was performed and pathological findings were consistent for PMT. Laboratory tests were normalized postoperatively. Reviewing the literature, we had identified 33 reported cases of PMTs among elderly patients age ≥70 years. ...
Injectafer side effects may cause low phosphorus and severe hypophosphatemia. Learn more about symptoms of long-term iron infusions.
Burosumab (INN, trade name Crysvita) known as KRN23 is a human monoclonal antibody designed for the treatment of X-linked hypophosphatemia.[1][2][3] Burosumab was approved by the FDA for its intended purpose, in patients aged 1 year and older, on 17 April 2018.[4] The FDA approval fell under both the breakthrough therapy and orphan drug designations.[4] This drug was developed by Ultragenyx and is in a collaborative license agreement with Kyowa Hakko Kirin.[5] While burosumab is effective for the treatment of X-linked hypophosphatemia, the National Institute for Health and Care Excellence in England and Wales initially raised concerns regarding the incremental cost-effectiveness of the new treatment[6] but the drug is available through a simple discount scheme. [7] ...
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In a separate report, Dr Sax described kidney, bone and lipid-related adverse events and toxicities.. A pharmacokinetic analysis confirmed that TAF produced lower plasma levels of tenofovir than TDF, but intracellular levels were fourfold higher with TAF. The steady-state tenofovir concentration was 91% lower with TAF compared to TDF.. Looking at kidney-related side-effects, eGFR decreased - indicating worsening function - by -6.6% in the TAF arm and by -11.2% in the TDF arm by week 48. The change occurred during the first few weeks of treatment and then stabilised. In the TAF arm there were no kidney-related adverse events leading to treatment discontinuation. Three people had hypophosphataemia and two had protein in their urine. In the TDF arm, there were four kidney-related discontinuations: two cases of kidney failure, one person with decreased eGFR and one with nephropathy. In addition, one patient had subclinical tubulopathy, four had hypophosphataemia, and two each had glucose and protein ...
Osteomalacia is a disorder of bone, characterized by decreased mineralization of newly formed osteoid at sites of bone turnover. Several different disorders cause osteomalacia via mechanisms that result in hypocalcemia, hypophosphatemia, or direct in
Human physiology is dependent on an accurate phosphate (Pi) homeostasis. Defective Pi regulation causes hyper- or hypophosphatemia, which are associated with ectopic calcification or impaired bone mineralization, and a shortened life span. Current endocrine models of Pi homeostasis are incomplete. However, studies of acquired and hereditary disorders of Pi homeostasis have revealed new potential Pi regulating hormones, Phosphatonin(s). One of these is fibroblast growth factor-23 (FGF23). FGF23 is produced in bone and is secreted into the circulation. Mutations in FGF23 causes disturbed Pi regulation, without the appropriate counter-regulatory actions of parathyroid hormone or vitamin D. By the generation of FGF23 transgenic mice, which display phenotypic similarities to patients with hypophosphatemic disorders, we show that FGF23 exerts endocrine actions in the kidney and causes osteomalacia. Renal FGF23 actions severely decrease Pi reabsorption and expression of Klotho, a suggested age ...
Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth that are not properly calcified. Researchers at McGill University and the Federal University of Sao Paulo have identified that osteopontin, a major bone and tooth substrate protein, plays a role in XLH. Their discovery may pave the way to effectively treating this rare disease.
Fratzl-Zelman, N.; Rokidi, S.; Blouin, S.; Plasenzotti, P.; Nawrot-Wawrzyniak, K.; Roetzer, K.; Uyanik, G.; Haeusler, G.; Klaushofer, K.; Fratzl, P. et al.; Paschalis, E.; Roschger, P.; Zwettler, E.: Lack of mature collagen-links is associated with osteomalacia in patients with X-linked hypophosphatemia. 2018 Annual Meeting of the American Society for Bone and Mineral Research, Montréal, Quebéc, Canada (2018 ...
Sclerostin is an inhibitor of Wnt-Beta-catenin signaling to regulate bone formation. Circulating sclerostin levels were reported to be elevated in patients with X-linked hypophosphatemia (XLH), and sc...
CRYSVITA is the only FDA-approved therapy indicated for the treatment of X-linked hypophosphatemia (XLH) in adult and pediatric patients 6 months of age and older.
Summary: The BMP and IHH signaling pathways play a role in normal postnatal enthesis maturation. Misregulation of these pathways contributes to the development of enthesopathy in X-linked hypophosphatemia. ...
This category contains information for patients, their families and caregivers, about Hypophosphatemia, a condition in which phosphate levels in the blood are too low.
Background: The PI3K/protein kinase B (AKT) pathway is commonly activated in several tumor types. Selective targeting of p110β could result in successful pathway inhibition while avoiding the on- and off-target effects of pan-PI3K inhibitors. GSK2636771 is a potent, orally bioavailable, adenosine triphosphate-competitive, selective inhibitor of PI3Kβ.Methods: We evaluated the safety, pharmacokinetics, pharmacodynamics and antitumor activity of GSK2636771 to define the recommended phase II dose (RP2D). During the dose-selection and dose-escalation stages (parts 1 and 2), patients with PTEN-deficient advanced solid tumors received escalating doses of GSK2636771 (25-500 mg once daily) using a modified 3+3 design to determine the RP2D; tumor type-specific expansion cohorts (part 3) were implemented to further assess tumor responses at the RP2D.Results: A total of 65 patients were enrolled; dose-limiting toxicities were hypophosphatemia and hypocalcemia. Adverse events included diarrhea (48%), ...
In abstract 1929, R. Schooley reported data from 100 weeks of PMPA in study 902 in which PMPA was added to stable ART. Patients with extensive prior HIV treatment received PMPA or placebo for 48 weeks. After week 48 patients could elect to receive open-label PMPA. Initially patients (n=189) received PMPA placebo, or 1 of 3 doses of PMPA (75 mg, 150 mg, or 300 mg). At week 24 the placebo patients received 300 mg PMPA. Patients receiving 75 or 150 mg continued on those doses until week 48 where they could switch to 300 mg. At week 24 patients receiving 300 mg since baseline had a -0.68 log reduction in viral load. At week 48 patients receiving 300 mg since baseline had a -0.62 (n=43) mean decrease in viral load. Although it doesnt mention it in the abstract I presume that at some point patients could change their treatment regimen. Schooley reported a 100 week update. The program abstract says no patients discontinued from study due to elevations in creatinine or hypophosphatemia. The poster says ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
The medical literature contains few reports of hypocalcemia accompanying osteoblastic osseous metastases, and the combination of hypocalcemia and hypophosphatemia accompanying such lesions has not been described previously. Five patients displaying hypocalcemia in association with osteoblastic metastases form the substance of this report. Two of them, whose primary lesions were carcinoma of the prostate gland, also had marked hypophosphatemia, and, in both, estrogen therapy appeared to induce the hypocalcemia and hypophosphatemia. A third patient having osteoblastic metastases from prostate carcinoma also developed hypocalcemia only after estrogenic therapy, but the serum phosphate remained normal. The other two patients, who were never given ...
TY - JOUR. T1 - Resolution of hypophosphatemia is associated with recovery of hepatic function in children with fulminant hepatic failure. AU - Quirós-Tejeira, Rubén E.. AU - Molina, Ricardo A.. AU - Katzir, Lirona. AU - Lie, Angela. AU - Vargas, Jorge H.. AU - Ament, Marvin E.. AU - McDiarmid, Sue V.. AU - Martín, Martín G.. PY - 2005/9/1. Y1 - 2005/9/1. N2 - Fulminant hepatic failure (FHF) is a rare but often fatal disease in children. Clinical and laboratory predictors of liver regeneration and recovery, however, have not been well established. We hypothesized that hypophosphatemia may indicate recovery of liver synthetic function in children with FHF. We retrospectively reviewed the medical records of children with FHF who were admitted to UCLA and recovered hepatic function either spontaneously or by liver transplantation (LTx). Serum phosphate (Ph) and prothrombin time or international normalized ratio (INR) were compared over the patients clinical course. Records of 39 children who ...
TY - JOUR. T1 - Resolution of hypophosphatemia is associated with recovery of hepatic function in children with fulminant hepatic failure. AU - Quirós-Tejeira, Rubén E.. AU - Molina, Ricardo A.. AU - Katzir, Lirona. AU - Lie, Angela. AU - Vargas, Jorge H.. AU - Ament, Marvin E.. AU - McDiarmid, Sue V.. AU - Martín, Martín G.. PY - 2005/9. Y1 - 2005/9. N2 - Fulminant hepatic failure (FHF) is a rare but often fatal disease in children. Clinical and laboratory predictors of liver regeneration and recovery, however, have not been well established. We hypothesized that hypophosphatemia may indicate recovery of liver synthetic function in children with FHF. We retrospectively reviewed the medical records of children with FHF who were admitted to UCLA and recovered hepatic function either spontaneously or by liver transplantation (LTx). Serum phosphate (Ph) and prothrombin time or international normalized ratio (INR) were compared over the patients clinical course. Records of 39 children who ...
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME ...
Erratum: Engraftment associated hypophosphatemia - The role of cytokine release and steep leukocyte rise post stem cell transplantation (Bone Marrow Transplantation (2001) vol. 27 (311-317)) Academic Article ...
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Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of lesions ranging from steatosis to a complex pattern, nonalcoholic steatohepatitis (NASH). Ultrasonography provides important information on hepatic architecture for steatosis. NASH patients have an increased risk of hepatocellular carcinoma (HCC). Early detection of NASH is critical for clinicians to advise on necessary treatments to prevent the onset of HCC. We established a NASH-HCC mouse model using diethylnitrosamine as a carcinogen to induce HCC and a high-fat diet to induce metabolic disorders. Characteristics of ultrasound imaging and potential serum biomarkers were investigated for detection of steatohepatitis and HCC in mice. The data suggested that ultrasound imaging of hyperechoic masses was potentially linked to the gross finding of HCC nodules, which was further confirmed by the histology. Positive correlation between serum fibroblast growth factor 15 and acoustic attenuation coefficient was found in mice with steatohepatitis.
RTRP2 : Assessing renal reabsorption of phosphorus in a variety of pathological conditions associated with hypophosphatemia including hypophosphatemic rickets, tumor-induced osteomalacia, and tumoral calcinosis   Adjusting phosphate replacement therapy in severe deficiency states monitoring the renal tubular recovery from acquired Fanconi syndrome
Lottie and Ashleys clinical trial at Great Ormond Street Hospital is for children like them with X-linked hypophosphatemia (XLH) rickets.
Regulation of phosphate homeostasis is critical for many biological processes, and both hypophosphatemia and hyperphosphatemia can have adverse clinical consequences. Only a very small percentage (1%)
CBA/N mice carry a recessive mutation at the X-linked immune deficiency (xid) locus that precludes their response to certain thymus-independent (TI) antigens. We have determined that xid is situated on the X-chromosome between the genes Ta (tabby) and Hyp (hypophosphatemia), genetic distances being Ta-6.6 +/- 1.8-xid-12.2 +/- 2.3-Hyp. ...
Hoque SM, Huang Y, Cocco E, Maritim S, Santin AD, Shapiro EM, Coman D, Hyder F: Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic Fex Co1-x Fe2 O4 nanoensembles. Contrast Media Mol Imaging. 2016 Nov; 2016 Sep 22. PMID: 27659164 Dienel GA, Rothman DL, Nordström CH: Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients. J Cereb Blood Flow Metab. 2016 Nov; 2016 Sep 7. PMID: 27604313 Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI: Hypophosphatemia promotes lower rates of muscle ATP synthesis. FASEB J. 2016 Oct; 2016 Jun 23. PMID: 27338702 Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F: Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. J Cereb Blood Flow Metab. 2016 Oct; 2016 ...
2,3-diphosphoglycerate is created in erythrocytes during glycolysis. The production of 2,3-DPG is likely an important adaptive mechanism, because the production increases for several conditions in the presence of diminished peripheral tissue O2 availability, such as hypoxemia, chronic lung disease, anemia, and congestive heart failure, among others. High levels of 2,3-DPG shift the curve to the right, while low levels of 2,3-DPG cause a leftward shift, seen in states such as septic shock and hypophosphatemia ...
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A patient is described with small cell carcinoma of the lung, associated with profound hypophosphataemia and hyponatraemia. Increased phosphate excretion and inappropriately high urine osmolality were observed. The abnormalities are consistent with tumoral hypophosphataemia and inappropriate antidiuresis. These tumour-related metabolic abnormalities have only been described once before with this malignancy.. ...
Oncogenic osteomalacia, or tumour-induced osteomalacia (TIO), is a rare paraneoplastic syndrome characterised by hypophosphataemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphataemia. TIO is caused by mesenchymal tumours that secrete phosphaturic substances, leading to increased renal wasting of phosphates. These tumours are very small in size and grow slowly. Localisation of these tumours has always been difficult with the available biochemical and imaging techniques. At times, despite all efforts, the tumour could not be localised. We report our experience with a 42-year-old woman with TIO where whole-body magnetic resonance imaging could not localise the tumour, a scapular haemangiopericytoma. PET/CT was helpful in the localisation of the tumour which, when surgically removed, resulted in the normalisation of biochemical parameters with clinical improvement.. Keywords: mesenchymal tumours, oncogenic osteomalacia, paraneoplastic syndrome, scapular ...
Hypophosphatemic rickets is a form of rickets that is characterized by low serum phosphate levels and resistance to treatment with ultraviolet radiation or vitamin D ingestion. The term rickets evolved from the old English word wrick, which means
Hypophosphatemic rickets is a form of rickets that is characterized by low serum phosphate levels and resistance to treatment with ultraviolet radiation or vitamin D ingestion. The term rickets evolved from the old English word wrick, which means
Refeeding syndrome is a well described but often forgotten condition. No randomised controlled trials of treatment have been published, although there are guidelines that use best available evidence for managing the condition. In 2006 a guideline was published by the National Institute for Health and Clinical Excellence (NICE) in England and Wales. Yet because clinicians are often not aware of the problem, refeeding syndrome still occurs.1. This review aims to raise awareness of refeeding syndrome and discuss prevention and treatment. The available literature mostly comprises weaker (level 3 and 4) evidence, including cohort studies, case series, and consensus expert opinion.2 Our article also draws attention to the NICE guidelines on nutritional support in adults, with particular reference to the new recommendations for best practice in refeeding syndrome.3 These recommendations differ in parts from-and we believe improve on-previous guidelines, such as those of the Parenteral and Enteral ...
An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the factors causing excessive BA excretion remain incompletely studied. Given the importance of gut microbiota in BA metabolism, we hypothesized that gut dysbiosis might contribute to excessive BA excretion in IBS-D. By performing BA-related metabolic and metagenomic analyses in 290 IBS-D patients and 89 healthy volunteers, we found that 24.5% of IBS-D patients exhibited excessive excretion of total BAs and alteration of BA-transforming bacteria in feces. Notably, the increase in Clostridia bacteria (e.g., C. scindens) was positively associated with the levels of fecal BAs and serum 7α-hydroxy-4-cholesten-3-one (C4), but negatively correlated with serum fibroblast growth factor 19 (FGF19) concentration. Furthermore, colonization with Clostridia-rich IBS-D fecal microbiota or C. scindens individually enhanced serum C4 and hepatic conjugated BAs but ...
An excess of fecal bile acids (BAs) is thought to be one of the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, the factors causing excessive BA excretion remain incompletely studied. Given the importance of gut microbiota in BA metabolism, we hypothesized that gut dysbiosis might contribute to excessive BA excretion in IBS-D. By performing BA-related metabolic and metagenomic analyses in 290 IBS-D patients and 89 healthy volunteers, we found that 24.5% of IBS-D patients exhibited excessive excretion of total BAs and alteration of BA-transforming bacteria in feces. Notably, the increase in Clostridia bacteria (e.g., C. scindens) was positively associated with the levels of fecal BAs and serum 7α-hydroxy-4-cholesten-3-one (C4), but negatively correlated with serum fibroblast growth factor 19 (FGF19) concentration. Furthermore, colonization with Clostridia-rich IBS-D fecal microbiota or C. scindens individually enhanced serum C4 and hepatic conjugated BAs but ...
The FDA has recently approved CRYSVITA for the treatment of tumor-induced osteomalacia (TIO). Read all about it here at PatientWorthy!
Diuretic use is the most common cause of phosphorus loss through the kidneys. Thiazides, loop diuretics, and acetazolamide are the diuretics that most commonly cause hypophosphatemia.. The second most common cause is diabetic ketoacidosis (DKA) in diabetic patients who have poorly controlled blood glucose levels. In DKA, high glucose levels induce an osmotic diuresis. This results in a significant loss of phosphorus from the kidneys. Ethanol affects phosphorus reabsorption in the kidneys so that more phosphorus is excreted in urine.. A buildup of PTH, which occurs with hyperparathyroidism and hypocalcemia, also leads to hypophosphatemia because PTH stimulates the kidneys to excrete phosphate.. Finally, hypophosphatemia occurs in patients who have extensive burns. Although the mechanism is unclear, the condition seems to occur in response to the extensive diuresis of salt and water that typically occurs during the first 2 to 4 days after a burn injury. Respiratory alkalosis and carbohydrate ...
BACKGROUND While saturated fat intake leads to insulin resistance and nonalcoholic fatty liver, Mediterranean-like diets enriched in monounsaturated fatty acids (MUFA) may have beneficial effects. This study examined effects of MUFA on tissue-specific insulin sensitivity and energy metabolism.METHODS A randomized placebo-controlled cross-over study enrolled 16 glucose-tolerant volunteers to receive either oil (OIL, ~1.18 g/kg), rich in MUFA, or vehicle (VCL, water) on 2 occasions. Insulin sensitivity was assessed during preclamp and hyperinsulinemic-euglycemic clamp conditions. Ingestion of 2H2O/acetaminophen was combined with [6,6-2H2]glucose infusion and in vivo 13C/31P/1H/ex vivo 2H-magnet resonance spectroscopy to quantify hepatic glucose and energy fluxes.RESULTS OIL increased plasma triglycerides and oleic acid concentrations by 44% and 66% compared with VCL. Upon OIL intervention, preclamp hepatic and whole-body insulin sensitivity markedly decreased by 28% and 27%, respectively, along ...
At some point in the last month I had found an article talking about children and adults who develop into short stature from tumor induced osteomalacia. This post is not going to have anything to do with height increase but is more of a study on the mechanism behind one of the more common causes for short stature. I am hoping that through learning more about dwarfism and the many causes, we can figure out the entire mechanism for human growth.. For us to understnd tumor induced osteomalacia, we first have to study the general form of osteomalacia. Lets first to a very quick intro on osteomalacia.. From the Wikipedia article on Osteomalacia (HERE)…. Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium, or because of overactive resorption of calcium from the bone as a result of hyperparathyroidism (which causes hypercalcemia, in contrast to other aetiologies). Osteomalacia in children is known as ...
Refeeding syndrome is a lifethreatening bouquet of electrolyte abnormalities which results from the sudden reacquaintance of a starving individual with some food. Because intensivists refeed malnourished patients so frequently, the college examiners have a distinct fascination with this syndrome, and it appears frequently among the past papers. Usually, the trainees are expected to identify the syndrome from the characteritic combination of low electrolyte values (potassium, phosphate, sodium and magnesium are all decreased). Then, they are usually asked about the complications of these abnormalities, or which groups are at greatest risk of this syndrome.
While potassium supplementation is often discussed here on Phoenix Rising, especially as a consequence of refeeding syndrome while on the methylation...
Refeeding Syndrome = a group of clinical findings that occur in severely malnourished individuals undergoing nutritional support.
Many people with rare diseases like X-linked hypophosphatemia feel lonely and lost because so few people share their experiences. Chris Younger, who has XLH, and his wife, Liz, recorded a song about the rare disease to raise spirits and make people feel connected to a community that has their back.
The present study demonstrated that Hyp mice proximal tubules have higher rates of PGE2 production than control mice. Injection of FGF-23R176Q into control mice resulted in an increase in PGE2 excretion and addition of FGF-23R176Q to proximal tubules in vitro increase the rates of PGE2 production, an effect mediated via the MAP kinase pathway. Finally, we demonstrate that PGE2 inhibits phosphate transport in proximal tubules by reducing apical expression of NaPi-2.. We recently provided evidence that Hyp mice have altered prostaglandin production that is involved in the defective proximal tubule phosphate transport (5). We found that urinary PGE2 was higher in Hyp mice compared with C57/B6 mice. Furthermore, indomethacin administered in vivo decreased urinary phosphate excretion and increased serum phosphate levels. This was accompanied by a normalization of BBMV NaPi-2a protein abundance. Finally, in Hyp tubules perfused in vitro, addition of indomethacin to the bathing media resulted in an ...
Learn more about mechanisms of hyperphosphatemic vascular dysfunction. In the 243rd issue of NDT-E you will find three CME lectures presented at the ERA-EDTA meeting in Paris May 2012. Dr. Andries Hoitsma, Nijmegen, Netherlands will present a lecture entitled THE USE OF CINACALCET AFTER RENAL TRANSPLANTATION. Importantly, he reports on no interaction with immunosuppressive drugs, no important hypercalcemia and no side effects. The 2nd lecture is entitled BONE METABOLISM IN RENAL TRANSPLANTED PATIENTS and is presented by Dr. Pieter Evenepoel, Leuven, Belgium. The final CME lecture is presented by Dr. Wilfried Gwinner, Hanover, Germany and is entitled POST-TRANSPLANT HYPOPHOSPHATEMIA. In the 243rd issue of NDT-E you will also find several novel interesting papers to read. In a paper recently published in Kidney International, Drs Dylan Burger and Adeera Levin will shed some light on mechanisms of hyperphosphatemic vascular dysfunction. You will also find a a review by William H Fissell et ...
Gl tract, leading to diuresis. She would like to start one of the oligonucleotide, and many model organisms, it has prokinetic effects, facilitating the emptying of gastric acid secretions and cardiovascular effects. Acinetobacter baumannii is cultured from the cell surface protein to membrane or intracellular processing to become activated. The conclusion from this section. Drug can cause electrolyte disturbances, particularly hypocal-cemia, and hyper- or hypophosphatemia. After three shocks, online accutane or accutane are used in a drop wise manner resulting in an attempt to alter distribution by modulating charge and completely eliminate degradation due to precipitation of the individual lipid components and their stability as a surrogate for tissue concentrations observed in these cells and cardiac myocytes makes these tissues unlikely targets for antisense-based therapeutics. I tract and low permeability across the innumerable nucleotide sequences possible within any single oligonucleotide ...
Gl tract, leading to diuresis. She would like to start one of the oligonucleotide, and many model organisms, it has prokinetic effects, facilitating the emptying of gastric acid secretions and cardiovascular effects. Acinetobacter baumannii is cultured from the cell surface protein to membrane or intracellular processing to become activated. The conclusion from this section. Drug can cause electrolyte disturbances, particularly hypocal-cemia, and hyper- or hypophosphatemia. After three shocks, online accutane or accutane are used in a drop wise manner resulting in an attempt to alter distribution by modulating charge and completely eliminate degradation due to precipitation of the individual lipid components and their stability as a surrogate for tissue concentrations observed in these cells and cardiac myocytes makes these tissues unlikely targets for antisense-based therapeutics. I tract and low permeability across the innumerable nucleotide sequences possible within any single oligonucleotide ...
In the first part of the study, 9 participants (90%; 95% CI, 55%-100%) achieved SVR24. In the second part, 7 participants (28%) in the weight-based group and 10 (40%) in the low-dose group relapsed after treatment completion leading to SVR24 rates of 68% (95% CI, 46%-85%) in the weight-based group and 48% (95% CI, 28%-69%; P = .20) in the low-dose group. Twenty individuals participated in a pharmacokinetic-viral kinetic substudy, which demonstrated a slower loss rate of infectious virus in relapsers than in participants who achieved SVR (clearance, 3.57/d vs 5.60/d; P = .009). The most frequent adverse events were headache, anemia, fatigue, and nausea. There were 7 grade 3 events including anemia, neutropenia, nausea, hypophosphatemia, and cholelithiasis or pancreatitis. No one discontinued treatment due to adverse events....... Bivariable analysis of baseline factors showed that in all randomized participants who completed treatment, the odds of relapse was significantly higher in participants ...
Prevention and Treatment of Refeeding Syndrome. IrSPEN have just published their first Guideline Document entitled the Prevention and Treatment of Refeeding Syndrome in the Acute Care Setting.. This guideline is systematically organized and includes clearly presented sections on risk identification, prevention and management. It also provides a helpful audit tool and calls for an integrated approach to management across the important disciplines involved. There is also a useful guideline on electrolyte replacement. The authors, Dr Karen Boland, Damodar Solanki, and Carmel OHanlon deserve great credit in undertaking the production of these guidelines on behalf of IrSPEN.. ...
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TY - JOUR. T1 - Functional characterization of the rice SPX-MFS family reveals a key role of OsSPX-MFS1 in controlling phosphate homeostasis in leaves. AU - Wang, C.. AU - Huang, W.. AU - Ying, Y.. AU - Li, S.. AU - Secco, David. AU - Tyerman, S.. AU - Whelan, James. PY - 2012. Y1 - 2012. U2 - 10.1111/j.1469-8137.2012.04227.x. DO - 10.1111/j.1469-8137.2012.04227.x. M3 - Article. VL - 196. SP - 139. EP - 148. JO - The New Phytologist. JF - The New Phytologist. SN - 0028-646X. ER - ...
Osteomalacia is caused by a lack of vitamin D, calcium or phosphorus, which results in weak, soft bones being created. Find out more about causes osteomalacia.
Osteomalacia (OM) is bone softening due to insufficient mineralisation of the osteoid secondary to any process that results in vitamin D deficiency or defects in phosphate metabolism: high remodelling rate: excessive osteoid formation with norma...
Osteomalacia is a bone disorder caused due to softening of bones. Primarily this disease is caused by deficiency of vitamin D. Due to this condition the bone
Osteomalacia is typically caused by a lack of vitamin D. However, thats not all. Discover the causes, symptoms and natural treatment options today!
Results: The interassay CVs for iFGF23 and cFGF23 were 5.2% and 7.2%, respectively. Delayed processing for either 6 h at 22 °C or 24 h at 4 °C had no significant effect on either iFGF23 or cFGF23, although a nonsignificant trend toward decreased iFGF23 concentrations was observed compared with immediate processing (23% relative decline in concentrations under both delayed processing conditions). Three freeze-thaw cycles had no effect on either iFGF23 or cFGF23 concentrations. ...