Given that severe hypoglycemia affects 40% of insulin-treated people with diabetes (26), concern regarding the hazardous potential for severe hypoglycemia to cause brain damage continues to be a very real barrier for realizing the full benefits of intensive glycemic control (27). Patients with the highest incidence of severe hypoglycemia are most often those who maintain intensive glycemic control and, hence, are likely to have had recurrent bouts of moderate hypoglycemia. In this study, recurrent moderate hypoglycemia preconditioned the brain and protected it against brain damage and cognitive dysfunction induced by severe hypoglycemia.. In these experiments, severe hypoglycemic brain injury was consistently induced with hyperinsulinemic-hypoglycemic (,15 mg/dl) clamps that carefully controlled the depth and duration of severe hypoglycemia and avoided the confounding effects of anesthesia (28-31). The amount and distribution of neuronal damage was markedly different between the 60- and 90-min ...

To test the hypothesis that the neuroendocrine (including autonomic) responses to hypoglycemia are dissociated from the symptomatic responses to hypoglycemia in insulin-dependent diabetes mellitus (IDDM) patients with hypoglycemia awareness and during reversal of hypoglycemia unawareness in IDDM, we used the hyperinsulinemic stepped hypoglycemic (5.0, 4.4, 3.9, 3.3, 2.8, and 2.2 mmol/l) clamp technique to quantitate these responses in nondiabetic control subjects and IDDM patients with hypoglycemia awareness and with hypoglycemia unawareness. The latter were restudied after 3 days, 3-4 weeks, and 3 months of scrupulous avoidance of iatrogenic hypoglycemia. At baseline, symptom responses were virtually nil in unaware patients (P = 0.0001 vs. nondiabetic); these were increased in aware patients (P = 0.0183 vs. nondiabetic). In contrast, several neuroendocrine responses were comparably reduced in both unaware and aware patients: epinephrine (P = 0.0222 and 0.0156), pancreatic polypeptide (P = ...

Neonatal hypoglycemia - MedHelps Neonatal hypoglycemia Center for Information, Symptoms, Resources, Treatments and Tools for Neonatal hypoglycemia. Find Neonatal hypoglycemia information, treatments for Neonatal hypoglycemia and Neonatal hypoglycemia symptoms.

OBJECTIVE: To evaluate the clinical/research utility of the biopsycho-behavioral model of severe hypoglycemia in differentiating patients with and without a history of severe hypoglycemia and in predicting occurrence of future severe hypoglycemia. RESEARCH DESIGN AND METHODS: A total of 93 adults with type 1 diabetes (mean age 35.8 years, duration of diabetes 16 +/- 10 years, HbA1 8.6 +/- 1.8%), 42 of whom had a recent history of recurrent severe hypoglycemia (SH) and 51 who did not (NoSH), used a handheld computer for 70 trials during 1 month recording cognitive-motor functioning, symptoms, blood glucose (BG) estimates, judgments concerning self-treatment of BG, actual BG readings, and actual treatment of low BG. For the next 6 months, patients recorded occurrence of severe hypoglycemia. RESULTS: SH patients demonstrated significantly more frequent and extreme low BG readings (low BG index), greater cognitive-motor impairments during hypoglycemia, fewer perceived symptoms of hypoglycemia, and ...

Semantic Scholar extracted view of [Effect of treatment by mild insulin-induced hypoglycemia on urinary excretion of neutral 17-ketosteroids; research on mechanism of insulin-induced hypoglycemia]. by A Kleczeński

Hyperinsulinism can occur throughout childhood but is most common in infancy. Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is the most important cause of hypoglycemia in early infancy. The excessive secretion of insulin is responsible for profound hypoglycemia and requires aggressive treatment to prevent severe and irreversible brain damage. Onset can be in the neonatal period or later, with the severity of hypoglycemia decreasing with age. PHHI is a heterogeneous disorder with two histopathological lesions, diffuse (DiPHHI) and focal (FoPHHI), which are clinically indistinguishable. FoPHHI is sporadic and characterized by somatic islet-cell hyperplasia. DiPHHI corresponds to a functional abnormality of insulin secretion in the whole pancreas and is most often recessive although rare dominant forms can occur, usually outside the newborn period. Differentiation between focal and diffuse lesions is important because the therapeutic approach and genetic counselling differ radically. ...

Some of the most common etiologies of postprandial hypoglycemia (which is also known as reactive hypoglycemia) include the following eiologies. Alimentary. Postprandial Hypoglycemia of gastrointestinal tract origin (sometimes called the dumping syndrome) most often occurs after gastric surgery and results from unusually swift or complete gastric emptying of ingested carbohydrate into the duodenum, resulting in abnormally high blood glucose levels and temporary hypoglycemia after hastily produced insulin has overcome the initial hyperglycemia. Initial blood glucose elevation is definitely greater than that of a normal person.. Diabetic. Some persons with subclinical or early diabetes mellitus of the NDDG type II (noninsulin-dependent) category may develop mild and transitory hypoglycemia 3-5 hours after eating. This seems to be an early manifestation of their disease, which often disappears as the disease progresses. The exact incidence in diabetics is unclear but is probably low. However, ...

Self-reported severe hypoglycemia was common (10.8%) among type 2 diabetic patients treated with glucose-lowering therapy within a large, integrated healthcare system. Among patients with severe hypoglycemia, nearly one in four people reported frequent episodes (more than three over the past year). Intensive glucose control strategies have been previously shown to increase the risk of hypoglycemia in clinical trials, but we did not find an inverse relationship between HbA1c level and hypoglycemia. Instead, in our study, hypoglycemia was common at all levels of glycemic control. Patients achieving near-normal glycemia (,6%) and those who were poorly controlled (≥9%) appeared to be at the highest risk for severe hypoglycemia. The conventional wisdom that patients with lowest HbA1c levels are at highest risk of hypoglycemia was not supported by our findings.. Our study expands prior research by examining the occurrence of hypoglycemia across multiple HbA1c categories and by using an outcome of ...

TY - JOUR. T1 - Association between hypoglycaemia and impaired hypoglycaemia awareness and mortality in people with Type 1 diabetes mellitus. AU - Sejling, A. S.. AU - Schouwenberg, B.. AU - Færch, Louise H. AU - Thorsteinsson, B.. AU - de Galan, B. E.. AU - Pedersen-Bjergaard, Ulrik. PY - 2016. Y1 - 2016. N2 - Aims: To examine whether severe hypoglycaemia and impaired hypoglycaemic awareness, a principal predictor of severe hypoglycaemia, are associated with all-cause mortality or cardiovascular mortality in Type 1 diabetes mellitus. Methods: Mortality was recorded in two cohorts, one in Denmark (n = 269, follow-up 12 years) and one in the Netherlands (n = 482, follow-up 6.5 years). In both cohorts, awareness class was characterized and numbers of episodes of severe hypoglycaemia either during lifetime (Danish cohort) or during the preceding year (Dutch cohort) were recorded. In addition, episodes of severe hypoglycaemia were prospectively recorded every month for 1 year in the Danish cohort. ...

This study examined the relationship between hypoglycemia occurring during ICU stay and hospital mortality in three cohorts of patients. The salient finding is that even a single episode of mild hypoglycemia, defined as BG , 70 mg/dL, was associated with increased risk of mortality. A major strength of this investigation includes the nature of the aggregated patient cohort, involving patients from different countries, with varying severities of illness and ICU LOS, treated in ICUs using different glycemic targets, measurement technologies and glycemic management protocols. Notably, the association between hypoglycemia and mortality was different among cohorts with different strategies of glucose control. The highest relative risk for mortality was seen in the cohort with the lowest rates of hypoglycemia while the lowest risk for mortality was seen in the cohort in whom short episodes of mild hypoglycemia were accepted as part of the guideline for IIT. The association between hypoglycemia and ...

Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes Bo Ahrén Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, Lund, Sweden Abstract: Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering strategy, where hypoglycemia may be a limitation for the therapy and also a factor underlying clinical inertia. Glucose-lowering medications that increase circulating insulin in a glucose-independent manner, such as insulin and sulfonylurea therapy, are the most common cause of hypoglycemia. However, other factors such as a delayed or missed meal, physical exercise, or drug or alcohol consumption may also contribute. Specific risk factors for development of hypoglycemia are old age, long duration of diabetes, some concomitant medication, renal dysfunction, hypoglycemia unawareness, and cognitive dysfunction. Hypoglycemia is associated with acute short-term symptoms

Bo Ahrén Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, Lund, Sweden Abstract: Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering strategy, where hypoglycemia may be a limitation for the therapy and also a factor underlying clinical inertia. Glucose-lowering medications that increase circulating insulin in a glucose-independent manner, such as insulin and sulfonylurea therapy, are the most common cause of hypoglycemia. However, other factors such as a delayed or missed meal, physical exercise, or drug or alcohol consumption may also contribute. Specific risk factors for development of hypoglycemia are old age, long duration of diabetes, some concomitant medication, renal dysfunction, hypoglycemia unawareness, and cognitive dysfunction. Hypoglycemia is associated with acute short-term symptoms related to either counterregulation, such as tachycardia and sweating, or to neuroglycopenia, such as

The mechanism underlying the increased mortality among patients with severe hypoglycaemia has yet to be elucidated. A potential possibility, however, is that cardiac ischaemia or fatal arrhythmia during recognised or unrecognised episodes of hypoglycaemia is responsible, particularly in the setting of cardiac autonomic neuropathy.17 In a detailed study using simultaneous continuous glucose monitoring and electrocardiogram monitoring among 19 patients with type 2 diabetes and coronary artery disease who were being treated with insulin, 10 episodes of angina and four episodes of cardiac ischaemia were seen in the 26 recorded episodes of symptomatic hypoglycaemia. In addition, two occasions of ischaemia were seen in 28 episodes of asymptomatic hypoglycaemia.18 Change in QT interval and QT dispersion have been seen during controlled episodes of hypoglycaemia in other studies.19 20. Those participants who experienced a severe hypoglycaemic event-both in the intensive treatment arm and in the standard ...

The mechanism underlying the increased mortality among patients with severe hypoglycaemia has yet to be elucidated. A potential possibility, however, is that cardiac ischaemia or fatal arrhythmia during recognised or unrecognised episodes of hypoglycaemia is responsible, particularly in the setting of cardiac autonomic neuropathy.17 In a detailed study using simultaneous continuous glucose monitoring and electrocardiogram monitoring among 19 patients with type 2 diabetes and coronary artery disease who were being treated with insulin, 10 episodes of angina and four episodes of cardiac ischaemia were seen in the 26 recorded episodes of symptomatic hypoglycaemia. In addition, two occasions of ischaemia were seen in 28 episodes of asymptomatic hypoglycaemia.18 Change in QT interval and QT dispersion have been seen during controlled episodes of hypoglycaemia in other studies.19 20. Those participants who experienced a severe hypoglycaemic event-both in the intensive treatment arm and in the standard ...

Hypoglycemia is probably like an alcoholic. In both cases a diabetic doesnt recognize his or her lows and an alcoholic not knowing they are drunk. In my case diabetic lows became hard to recognize do to age. I have been told by a couple of endos that our bodies adjust to the lows because of the frequency of having them. Having less lows over a longer period of time I think will help the body recognize that you are having a low. Nocturnal Hypoglycemia is my worst enemy. I can usually recognize have a low while awake but at night I am dependent upon setting a clock at 2:00 AM just to make sure. I tend to run low at the time of the morning and many of times required me taking orange juice just so that I dont have a hypoglycemic episode. I found some info on the internet that you may find interesting to note. Hypoglycemia unawareness - Hypoglycemia unawareness occurs when you do not have the early symptoms of low blood sugar. As a result, you cannot respond in the early stages, and severe signs ...

Several studies have evaluated the effects of the methylxanthine derivatives caffeine and theophylline on hypoglycemia unawareness and the counterregulatory response to hypoglycemia. Both have been shown to magnify the counterregulatory hormone (i.e., epinephrine, norepinephrine, and cortisol) response to hypoglycemia, as well as recovery from and perception of hypoglycemia in patients with type 1 diabetes both with and without hypoglycemia unawareness.1. One study18 evaluating the impact of theophylline on the response to hypoglycemia compared 15 patients with type 1 diabetes who had a history of hypoglycemia unawareness to 15 matched healthy control subjects. The subjects underwent hyperinsulinemic-hypoglycemic glucose clamp and randomly received either theophylline or placebo in a crossover fashion. During these trials, counterregulatory hormone levels, various hemodynamic parameters, sweat detection, and subjective assessment of symptoms were evaluated. When compared with placebo, ...

Supercompensated brain glycogen levels may contribute to the development of hypoglycemia-associated autonomic failure (HAAF) following recurrent hypoglycemia (RH) by providing energy for the brain during subsequent periods of hypoglycemia. To assess the role of glycogen supercompensation in the generation of HAAF, we estimated the level of brain glycogen following RH and acute hypoglycemia (AH). After undergoing 3 hyperinsulinemic, euglycemic and 3 hyperinsulinemic, hypoglycemic clamps (RH) on separate occasions at least 1 month apart, five healthy volunteers received [1-C]glucose intravenously over 80+ h while maintaining euglycemia. C-glycogen levels in the occipital lobe were measured by C magnetic resonance spectroscopy at ∼8, 20, 32, 44, 56, 68 and 80 h at 4 T and glycogen levels estimated by fitting the data with a biophysical model that takes into account the tiered glycogen structure. Similarly, prior C-glycogen data obtained following a single hypoglycemic episode (AH) were fitted ...

We believe this is the first study where full 12 hour glucose profiles have been obtained at home to mimic normal conditions. Because glucose concentrations were not measured until after the profile, no intervention was needed, and episodes of hypoglycaemia were undoubtedly asymptomatic. The high prevalence and severity of the nocturnal hypoglycaemia was unexpected although comparable with data from other studies.5 7 8 The prevalence of 45% (study night 1) was comparable to that seen in French children (47%),5despite the fact that UK children are routinely given a bedtime snack, whereas French children are not. Nocturnal hypoglycaemia has also been found to be common in young children in Spain even when food is consumed much later in the evening.7 A major concern is the possible effect of nocturnal hypoglycaemia on cognitive function the next day.30 31 Studies of experimentally induced hypoglycaemia in adults suggest that cognitive performance can return to normal within an hour of glucose ...

We found that hypoglycemia occurs frequently and is often severe among patients with CKD and type 2 DM. The greatest number of events occurred overnight from midnight until the early morning hours. Prolonged, severe hypoglycemic events as defined by the International Consensus on Use of Continuous Glucose Monitoring (12) occurred in ,38% of patients in 14 days of monitoring. Importantly, both lower HbA1c and use of any insulin treatment were associated with increased hypoglycemia risk.. Hypoglycemia is a cause of morbidity and mortality in patients with type 2 DM. In the ACCORD trial, hypoglycemia was more common among patients with type 2 DM who were randomized to intensive treatment. The higher rate of mortality in these patients compared with those treated with a conventional glucose target has suggested that hypoglycemia may have contributed to inferior outcomes (4). Hypoglycemia also increases anxiety among patients and may hinder the ability to achieve optimal chronic glucose control, as ...

To assess the changes in counterregulatory hormones overnight after an afternoon of structured exercise or sedentary activity in children with type 1 diabetes mellitus (T1DM), the Diabetes Research in Children Network (DirecNet) studied 50 children (10 to |18 yr) with T1DM in five clinical resear …

Hypoglycemia is the most frequent metabolic abnormality in the newborn, but no consensus exists on what level of blood glucose is able to protect the brain and influence the childs neural development and which is the best course of management in cases labeled as hypoglycemia. Early diagnosis, urgent treatment, and prevention of future episodes of hypoglycemia are the cornerstones of management, now supported by recent advances in molecular genetics and in our understanding of the pathophysiology of neonatal hypoglycemia, particularly the pathogenesis of congenital hyperinsulinemic hypoglycemia.

Hypoglycemia is associated with increased mortality in critically ill patients. The impact of hypoglycemia on resource utilization has not been investigated. The objective of this investigation was to evaluate the association of hypoglycemia, defined as a blood glucose concentration (BG) | 70 mg/dL, and intensive care unit (ICU) length of stay (LOS) in three different cohorts of critically ill patients. This is a retrospective investigation of prospectively collected data, including patients from two large observational cohorts: 3,263 patients admitted to Stamford Hospital (ST) and 2,063 patients admitted to three institutions in The Netherlands (NL) as well as 914 patients from the GLUCONTROL trial (GL), a multicenter prospective randomized controlled trial of intensive insulin therapy. Patients with hypoglycemia were more likely to be diabetic, had higher APACHE II scores, and higher mortality than did patients without hypoglycemia. Patients with hypoglycemia had longer ICU LOS (median [interquartile

Hypoglycemia is associated with increased mortality in critically ill patients. The impact of hypoglycemia on resource utilization has not been investigated. The objective of this investigation was to evaluate the association of hypoglycemia, defined as a blood glucose concentration (BG) | 70 mg/dL, and intensive care unit (ICU) length of stay (LOS) in three different cohorts of critically ill patients. This is a retrospective investigation of prospectively collected data, including patients from two large observational cohorts: 3,263 patients admitted to Stamford Hospital (ST) and 2,063 patients admitted to three institutions in The Netherlands (NL) as well as 914 patients from the GLUCONTROL trial (GL), a multicenter prospective randomized controlled trial of intensive insulin therapy. Patients with hypoglycemia were more likely to be diabetic, had higher APACHE II scores, and higher mortality than did patients without hypoglycemia. Patients with hypoglycemia had longer ICU LOS (median [interquartile

Newborn baby lethargy, Po mom should be wary of hypoglycemia - the birth of newborn babies and mothers of the Sohu after the baby seems to have only one state: eat sleep, eat sleep. Indeed, such a baby is very good, but the mother should also know that the baby must wake up after 3 hours of sleep to breastfeed, or there may be hypoglycemia. So what is the baby hypoglycemia? How does it affect the baby? Why baby baby feeding interval can not be more than 3 hours? Neonatal hypoglycemia is mostly asymptomatic. The early time showed lethargy and feeding difficulties, it may appear hypotonia, apnea, paroxysmal cyanosis, may also be manifested as irritability, tremors, convulsions. In particular, when the baby is initially manifested as drowsiness, is very easy to be ignored. Therefore, in order to avoid the occurrence of neonatal hypoglycemia, we ask the baby to be born after the feeding interval of not more than 3 hours. What harm does newborn hypoglycemia have? Neonatal hypoglycemia refers to the ...

Hypoglycaemia is one of the most common endocrine emergencies in practice.9 Early diagnosis of hypoglycaemia and determination of the underlying cause is necessary for appropriate diagnosis.1 One study dealt with patients in whom hypoglycaemia developed in hospital.2 There are few data on the aetiology of hypoglycaemia in patients admitted with hypoglycaemia.. Hypoglycaemia is most commonly seen in diabetic patients, in whom it is commonly due to overdose of anti-diabetic agents, low calorie intake, malnutrition, excessive exercise, prolonged starving, and development of either renal or hepatic failure.3 5 10Fischer et al 2 reported that 64 hypoglycaemic episodes were due to low calorie intake and inappropriate insulin therapy in 42 diabetic patients. In 20 of these 42 patients, hypoglycaemia was due to chronic renal failure.2 We have found that hypoglycaemia in 54 (42%) patients was due to inappropriate insulin use in 32 patients and to oral anti-diabetic drugs (sulfonylureas) in the remainder. ...

AIMS: We propose a study design with controlled hypoglycaemia induced by subcutaneous injection of insulin and matched control episodes to bridge the gap between clamp studies and studies of spontaneous hypoglycaemia. The observed prolongation of the heart rate corrected QT interval (QTc) during hypoglycaemia varies greatly between studies. METHODS: We studied ten adults with type 1 diabetes (age 41±15years) without cardiovascular disease or neuropathy. Single-blinded hypoglycaemia was induced by a subcutaneous insulin bolus followed by a control episode on two occasions separated by 4weeks. QT intervals were measured using the semi-automatic tangent approach, and QTc was derived by Bazetts (QTcB) and Fridericias (QTcF) formulas. RESULTS: QTcB increased from baseline to hypoglycaemia (403±20 vs. 433±39ms, p,0.001). On the euglycaemia day, QTcB also increased (398±20 vs. 410±27ms, p,0.01), but the increase was less than during hypoglycaemia (p,0.001). The same pattern was seen for QTcF. ...

Idiopathic hypoglycemia is, literally, a medical condition in which the glucose level in the blood (blood glucose) is abnormally low due to an undeterminable cause. This is considered an incomplete and unsatisfactory diagnosis by physicians and is rarely used by endocrinologists, as it implies an unfinished diagnostic evaluation. In general, the more severe the hypoglycemia and the more clearly it is proven, the less likely it is to remain idiopathic. Idiopathic hypoglycemia can also be a synonym for reactive hypoglycemia or for hypoglycemia that is not diagnosed by a physician and does not fulfill the Whipple triad criteria. A more precise term for that condition is idiopathic postprandial syndrome. Hyperinsulinism Perry, Julian C.; Bourne, Blanche; Lester Henry, W. (January 1957). Idiopathic Hypoglycemia in Childhood: Report of a Case. Journal of the National Medical Association. 49 (1): 29-32. ISSN 0027-9684. PMC 2641125 . PMID 13385682 ...

A blood glucose (BG) ≤ 70 mg/dL is classified as an alert value; a BG ,54 mg/dL is clinically significant biochemical hypoglycemia; and severe hypoglycemia is defined as any level associated with severe cognitive impairment requiring external assistance.2 Mild symptoms of hypoglycemia can include, tremor, sweating, hunger, tachycardia, a result of sympathoadrenal and parasympathetic responses, are usually annoying, but well tolerated, but if not managed, can progress to moderate symptoms of anxiety, irritability, confusion, or delirium and to severe hypoglycemia with loss of consciousness, seizure, coma, or even death.. Whether severe hypoglycemia is a risk marker or a direct causal effect for adverse CV outcomes is controversial. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study,3 was designed to determine whether a therapeutic strategy targeting A1C levels to a normal goal, i.e. ,6.0%, would reduce the rate of CV events, relative to patients with A1C levels ranging 7.0 ...

TY - JOUR. T1 - Opioid receptor activation impairs hypoglycemic counterregulation in humans. AU - Carey, Michelle. AU - Gospin, Rebekah. AU - Goyal, Akankasha. AU - Tomuta, Nora. AU - Sandu, Oana. AU - Mbanya, Armand. AU - Lontchi-Yimagou, Eric. AU - Hulkower, Raphael. AU - Shamoon, Harry. AU - Gabriely, Ilan. AU - Hawkins, Meredith. N1 - Funding Information: Acknowledgments. The authors thank Cynthia Rivera, Sarah Reda, Morgan Drucker, Karen Gambina, and Jennifer Ognibene (all from Albert Einstein College of Medicine) for assistance with recruitment; Robin Sgueglia, Dr. Daniel Stein, and the staff of the Albert Einstein College of Medicine Clinical Research Center and Hormone Assay Core of Einsteins Diabetes Research Center (P60-DK-20541); and Dr. Dale Edgerton and the Hormone Assay and Analytical Services Core of Vanderbilt University Medical Center for their help with the measurement of plasma epinephrine concentrations. Funding. This work was supported by grants from the National Institute ...

In this issue of Pediatrics, Bateman et al1 have elegantly convinced readers that infants of mothers prescribed β-blockers in late pregnancy, in a large American database, have a significantly elevated risk (4.3%) of neonatal hypoglycemia, with an adjusted odds ratio of 1.68. This finding is important because β-blockers are used commonly to treat hypertensive orders in pregnancy, and in Bateman et als study ,10 000 women, 0.5% of pregnancies, delivering between 2003 and 2007 were exposed to β-blockers at the time of delivery. Their results are physiologically plausible because β-blockers cross the placenta, and the resultant sympathetic blockade could be expected to lead to hypoglycemia, which may be asymptomatic. Screening for hypoglycemia appears to be the natural conclusion. But should we?. The accepted definition of hypoglycemia at the time of this study was a blood glucose level ≤45 mg/dL (≤2.6 mmol/L).2 The authors verified the electronic diagnostic codes by a random sampling of ...

All hypoglycemia episodes were taken into account. Severe hypoglycemia: event requiring assistance of another person to administer carbohydrate, glucagons, or other resuscitative actions; Documented symptomatic hypoglycemia: event with typical symptoms accompanied by a measured plasma glucose concentration ,=70 mg/dL; Asymptomatic hypoglycemia: event not accompanied by typical symptoms but with a measured plasma glucose concentration ,=70 mg/dL; Probable symptomatic hypoglycemia: event with symptoms not accompanied by a plasma glucose determination ...

In a national cohort of veterans observed during 1 yr, the diagnoses of CKD and diabetes both were independent risk factors for hypoglycemia of any severity. CKD and diabetes interacted significantly, leading to a greater risk for mild to severe hypoglycemia in the presence of both diseases than that observed in either disease state alone. The clinical implications of hypoglycemias occurring in either an inpatient or an outpatient setting was evident in its association with 1-d mortality; however, the relative risk for death was greater with outpatient hypoglycemia. The risk for mortality was to some extent attenuated among patients with the diagnosis of CKD versus those without.. It is likely that the occurrence of hypoglycemia in patients with diabetes, with or without CKD, is largely related to use of diabetic therapies; however, in the case of patients without diabetes and with CKD, the underlying cause for hypoglycemia is not entirely clear. The association between hypoglycemia and ...

Dive into the research topics of Extent and prevalence of post-exercise and nocturnal hypoglycemia following peri-exercise bolus insulin adjustments in individuals with type 1 diabetes. Together they form a unique fingerprint. ...

Background: Most infants with persistent hyperinsulinaemic hypoglycaemia (PHH) are born large for gestational age (LGA) due to excessive anabolic effect of prenatal hyperinsulinism. However, other auxological characteristics than weight in infants with PHH have not been described well.. Objective: The objective of this investigation was to characterize anthropometric parameters at birth (weight, length, and head circumference) in PHH compared with those in idiopathic LGA.. Method: Clinical data in full term birth for PHH and idiopathic LGA were retrospectively collected at two institutions. We excluded infants of diabetic mothers or those with known overgrowth syndrome. Variables analysed included birth weight SDS, length SDS, and head circumference SDS. The variables between PHH and idiopathic LGA were compared using the Mann Whitney U test.. Results: The present study included seven infants with PHH and 134 with idiopathic LGA. The birth weight SDS in PHH (median, 3.03; range, 1.46 to 3.67) ...

1. The effects of insulin hypoglycaemia on cerebral blood flow and metabolism have been examined in unanaesthetized, unrestrained calves between 1 and 26 days after birth. 2. Cerebral blood flow was measured with an inert gas technique using molecular hydrogen, and cerebral metabolism was quantified by determination of arterio-cerebral venous (A--V) concentration differences for oxygen, glucose, lactate, pyruvate, acetoacetate, beta-D-hydroxybutyrate and ammonia. 3. During normoglycaemia the mean (A--V) difference for glucose was close to one sixth that of oxygen, on a molar basis. A small net loss of pyruvate from the brain was found, but there was no significant (A--V) difference for lactate. Arterial concentrations of acetoacetate and beta-D-hydroxybutyrate were low, and no utilization of ketone bodies by the brain was demonstrated. 4. Moderate hypoglycaemia (arterial plasma glucose concentration 1--2 m-mole/l.) had no measurable effect on either cerebral blood flow or metabolism. 5. During ...

This study demonstrates that combining a reduced basal-bolus insulin dose, along with low GI carbohydrate feeding, provides full protection from exercise-induced hypoglycemia for a total of 24 h after exercise. Notably, when basal insulin dose was reduced by 20%, there was a clear normalization of glycemia during the night, protecting all participants from nocturnal hypoglycemia with concomitant hyperglycemia. In addition, we show that adopting this strategy does not induce other metabolic disturbances.. To our knowledge, we have, for the first time, demonstrated that it is possible to completely avoid acute and late-nocturnal hypoglycemia in type 1 diabetes, despite performing a prolonged bout of moderate-to-vigorous intensity running (expending ∼740 kcal and running 7.3 km) exercise in the evening. In addition, we show that while protecting patients from hypoglycemia, it is also possible to reduce exposure to hyperglycemia. Typically, preventing hypoglycemia after exercise occurs as a ...

What you need to realize, however, is that hypoglycemia is fairly rare in those without diabetes. Its caused by problems with insulin medications, excessive alcohol abuse, severe hepatitis, and other health issues that have so many different other symptoms that anxiety is often the least of your worries.. Studies have looked at the relationship between hypoglycemia and panic attacks. A study of 10 panic attack suffers considered with hypoglycemia found that none of them had any signs or symptoms of this condition, especially not before or during the attacks. Another study actually took patients of panic attacks and gave them insulin to induce hypoglycemia, and none of them had an anxiety attack. There is little reason to believe that anxiety and hypoglycemia cause each other in many of those with anxiety disorders.. Most people refer to simple hunger as hypoglycemia, or they refer to it as low blood sugar. Hunger can cause anxiety symptoms as well. Without enough sugars and nutrients in your ...

TY - JOUR. T1 - Anti-insulin antibodies are a cause of hypoglycemia following pancreas transplantation. AU - Tran, Minou P.. AU - Larsen, Jennifer Lynn. AU - Duckworth, William C.. AU - Ruby, Elizabeth I.. AU - Miller, Suzanne A.. AU - Frisbie, Kecia. AU - Taylor, Rodney J.. AU - Stratta, Robert J.. PY - 1994/9. Y1 - 1994/9. N2 - OBJECTIVE - Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia following PTX. RESEARCH DESIGN AND METHODS - Twelve patients with established, repeated episodes of hypoglycemia following PTX (hypo) were case-matched to PTX recipients without hypoglycemic symptoms (control; n = 7). On the day of the study, fasting glucose, free and total immunoreactive insulin (IRI), C-peptide, proinsulin, and glucagon were drawn (time ...

After admission, Mrs. J. continued her aggressive, combative behavior, which included yelling and spitting at anyone who tried to interact with her. Initially, this behavior was attributed to her progressing dementia. Fingerstick blood glucose testing was impossible to carry out.. The diabetes care coordinator, who was also a nurse practitioner, questioned the insulin dose based on the patients weight and A1C of 7.1%. Instead of increasing the glargine dose as other providers had done before the transfer, the care coordinator decided to determine whether the cause of Mrs. J.s acting out was actually hypoglycemia rather than dementia. Her decision was based on clinical experience as well as the patients history of unconscious hypoglycemia and hypoglycemia unawareness. Mrs. J.s worsening mental health status, which included episodes of delirium, might be the result of hypoglycemia.. To test this theory, the care coordinator reduced the glargine dose by 5 units daily and changed the dosing time ...

Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and its management is challenging. Diazoxide is the first-line treatment, albeit not all patients will fully respond to it, as episodes of hypoglycaemia may persist and it entails unpleasant adverse effects. Sirolimus, an mTOR inhibitor, has reportedly been successful in treating children with severe diffuse HH, thus obviating the need for pancreatectomy. We report a girl with HH, with a novel heterozygous ABCC8 gene missense mutation (c.4154A,T/ p.Lys1385Thr), who was initially responsive to diazoxide therapy. After 11 months of diazoxide treatment, she developed intermittent, unpredictable breakthrough episodes of hypoglycaemia, in addition to generalized hypertrichosis and weight gain from enforced feeding to avoid hypoglycaemia. Sirolimus, which was commenced at 15 months of age, gradually replaced diazoxide, with significant reduction and abolition of hypoglycaemia. The ...

Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and its management is challenging. Diazoxide is the first-line treatment, albeit not all patients will fully respond to it, as episodes of hypoglycaemia may persist and it entails unpleasant adverse effects. Sirolimus, an mTOR inhibitor, has reportedly been successful in treating children with severe diffuse HH, thus obviating the need for pancreatectomy. We report a girl with HH, with a novel heterozygous ABCC8 gene missense mutation (c.4154A,T/ p.Lys1385Thr), who was initially responsive to diazoxide therapy. After 11 months of diazoxide treatment, she developed intermittent, unpredictable breakthrough episodes of hypoglycaemia, in addition to generalized hypertrichosis and weight gain from enforced feeding to avoid hypoglycaemia. Sirolimus, which was commenced at 15 months of age, gradually replaced diazoxide, with significant reduction and abolition of hypoglycaemia. The ...

Familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion, is linked to chromosome 11p14-15.1. The newly cloned high-affinity sulfonylurea receptor (SUR) gene, a regulator of insulin secretion, was mapped to 11p15.1 by means of fluorescence in situ hybridization. Two separate SUR gene splice site mutations, which segregated with disease phenotype, were identified in affected individuals from nine different families. Both mutations resulted in aberrant processing of the RNA sequence and disruption of the putative second nucleotide binding domain of the SUR protein. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene. ...

Although anti-insulin antibodies (IAs) are often observed in patients treated with general regimens of insulin, their existence is not thought to be related to hypoglycemia.1 However, IA-positive patients treated with human insulin may manifest unexplainable hypoglycemia.2-5 The IAs of these patients have a lower affinity and a higher binding capacity than those from patients with insulin autoimmune syndrome (IAS)6 or those who do not develop hypoglycemia when treated with insulin. Ceasing insulin administration2 and switching to insulin analogs,3 steroid therapy,4 or double filtration plasmapheresis (DFPP)5 are all therapies that have been advocated to treat such patients.. Recently, we described analog insulin-receiving patients who developed severe daytime hyperglycemia and morning hypoglycemia associated with IA formation.7 Such cases seem to be augmenting with the spread of insulin analog treatment, and, unfortunately, they did not appear to respond well to the aforementioned therapies. ...

article{3b545620-2f5d-4405-9964-2753884aaa8d, abstract = {The effect of moderate hypoglycaemia (venous blood glucose 2.0 +/- 0.2 mmol/l; mean +/- SD) on regional cerebral blood flow and cerebral volume was studied in a group of ten right-handed patients with Type 1 (insulin-dependent) diabetes mellitus (age 26.0 +/- 2.4 years, duration 18.4 +/- 3.8 years) using an intravenous Xenon 133 single photon emission computed tomography technique. After 10 min of hypoglycaemia, global cerebral blood flow had increased to 55.8 +/- 4.5 ml.100 g-1.min-1 compared to the initial normoglycaemic flow of 49.5 +/- 3.7 ml.100 g-1.min-1 (p < 0.01). A further increase in global cerebral blood flow to 59.5 +/- 4.5 ml.100 g-1.min-1 (p < 0.05) occurred 15 min after normalization of the blood glucose level. The global cerebral blood flow change from before hypoglycaemia to after recovery was inversely related to the initial glucose level. No change in the relative distribution of the regional cerebral blood flow ...

List of causes of Calcaneal bone deformity and Systemic disorders causing persistent hypoglycemia, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.

India Medtronic Diabetes offers insulin pump therapy & continuous glucose monitoring system for patients on multiple daily insulin injections for better diabetes management & improved quality of life.

TY - JOUR. T1 - V-Go insulin delivery system versus multiple daily insulin injections for patients with uncontrolled type 2 diabetes mellitus. AU - Winter, Abigail. AU - Lintner, Michaela. AU - Knezevich, Emily. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Type 2 diabetes mellitus affects over 29.1 million Americans, diagnosed and undiagnosed. Achieving and maintaining glycemic control for these patients is of extreme importance when working to prevent complications and improve quality of life for patients. The V-Go is a newly developed insulin delivery system. The push of a button inserts a needle into the patient once daily and remains attached for 24 hours. The V-Go is designed to release a set basal rate throughout the day, while allowing patients to provide up to 36 units of on-demand bolus insulin with the manual click of 2 buttons. It is a spring-loaded device filled daily with rapid-acting insulin that runs without the use of batteries or computer software. The main objective of this prospective ...

Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels. However, this hormone response can be altered in people with diabetes. Currently there are no therapeutic agents that can be used to improve the recovery from hypoglycemia (low blood sugar). Naltrexone is a tablet used to help people who are addicted to alcohol or morphine-based drugs to remain drug and alcohol-free but it can also affect the levels of the hormones which are released during hypoglycemia. The aim of this study is to determine whether naltrexone can be used to improve and accelerate the recovery from hypoglycemia in patients with type 1 diabetes ...

In our updated meta-analysis of randomized trials of intensive insulin therapy in critically ill patients, we found that such therapy had no effect on the overall risk of death. By including data from the largest trial of intensive insulin therapy, which was recently published,18 we provide the most current and precise estimate of the effect of intensive insulin therapy on mortality and severe hypoglycemia in the ICU setting. We found significant heterogeneity between studies, which was driven primarily by the 2 trials involving surgical patient populations.8,29 In keeping with this observation, our meta-regression analysis suggested that intensive insulin therapy may benefit patients in surgical ICUs. Finally, there was a 6-fold increased risk of severe hypoglycemia among patients given intensive insulin therapy compared with the control treatment. The risk of hypoglycemic events did not differ by type of ICU, or by intensity of insulin therapy.. Our meta-analysis showed a similar overall ...

Previous studies have shown that the α cell is critical for a normal counterregulatory response to insulin-induced hypoglycemia (4, 6-9). In fact, glucagon is widely thought to provide the primary defense against a low blood glucose level. On the other hand, insulin is known to exert a powerful restraining effect on glucagons action (3). This raises the question of how glucagon can have such a prominent role in counterregulation if it is so easily subject to insulins inhibitory action. The aim of the present study, therefore, was to determine the extent to which hypoglycemia enhances glucagons ability to overcome insulins inhibitory action on the liver and to shed light on the mechanism by which this occurs. The present results indicate that hypoglycemia (~50 mg/dl), or some factor associated with it, enhanced glucagons ability to increase glucose production almost 3-fold, even in the presence of extremely high insulin levels. Furthermore, they showed that this change reflected a marked ...

Studies estimate that up to 30% of people with type 1 diabetes experience severe hypoglycaemia each year1. Although hypoglycaemia is less common in people with type 2 diabetes than type 1 diabetes2, the actual number of cases of hypoglycaemia may be higher in type 2 diabetes due to the larger numbers of people with this condition. ...

RESOURCES: Hormone Health Network: Nondiabetic Hypoglycemia. Mayo Facility: Hypoglycemia. Allina Health And Wellness: Non-diabetic Hypoglycemia. Endotext: Non-Diabetic Hypoglycemia. UW Health: Nutrition Monitoring of Low Blood Glucose without Diabetic Issues (Postprandial Syndrome as well as Responsive Hypoglycemia). Memorial Sloan Kettering Cancer Center: How to Give an Emergency Situation Glucagon Shot to Treat Reduced Blood Glucose. American Diabetes Association: Hypoglycemia (Low Blood Sugar). Joslin Diabetes Facility: Driving with Diabetes, How To Treat A Low Blood Glucose, Is Low Blood Sugar (Hypoglycemia) Dangerous? Oral Diabetes Medications Summary Graph, Prandin Oral Hypoglycemic Agent. Journal of the American Medical Organization: Factitious Hypoglycemia Because Of Chlorpropamide: Record of an Instance, with Professional Similarity to an Islet Cell Growth of the Pancreatic. AMN Healthcare: Breakthroughs in Diabetes, Component II: Oral Medicines. ...

This study aimed to explore how community-dwelling Singaporean Chinese adults diagnosed with type 2 diabetes mellitus experience hypoglycaemia. A qualitative interpretive research design was employed. Semi-structured interviews were conducted with six participants from a Singaporean diabetes specialist outpatient clinic, transcribed verbatim and analysed using qualitative manual thematic analysis. Eight major themes emerged: experiencing symptoms, knowing hypoglycaemia is manageable, using acute measures, using preventative strategies; applying knowledge, identifying causes of hypoglycaemia, forming relationships and working with health-care professionals. Participants underestimated the impact of hypoglycaemia mainly due to their experiencing mild and infrequent episodes, and knowledge deficits. Health-care professionals roles were limited to information providers, and they were perceived as detached and impersonal. The implications are that health-care professionals need to provide more ...

One of the keys to a hypoglycemia diet is to ensure that your body is fed a constant supply of nutrients. So while skipping a meal is generally considered bad for a normal person, it is even worse for an individual with hypoglycemia. While dieting with hypoglycemia, no matter what macro-nutrient approach you use, be sure to consume at least five or six small meals daily, eating every two to three hours. A high-protein, low-carbohydrate diet can be used to mitigate the symptoms of hypoglycemia because it can keep blood sugar stable while keeping metabolism high, alleviating many of the common complaints with other diet types, such as lack of satiety and general mood swings. When on a low-carb, high-protein diet, you should strive to consume 30 to 40 percent of your total calories from protein, 20 percent or so from carbs and the remainder from healthy fats.. Keep in mind that a low-carb diet does not mean a no-carb diet; you still need to provide your body with some glucose for day-to-day ...

The PANORAMA pan-European Survey: impact of severe and non-severe hypoglycaemia on quality of life and other patient reported outcomes in patients with type 2 diabetes [Abstract 580]. / Bradley, Clare; Eschwège, E; de Pablos-Velasco , P; Parhofer, KG; Simon, D; Tafalla , M; Pascual, E; Gönder-Frederick , LA.. In: Diabetologia, Vol. 53, No. Supplement 1, 09.2010, p. S234-235.. Research output: Contribution to journal › Article ...

We reviewed 76 published cases of Doege-Potter syndrome, and non-islet cell tumor hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT) between 1989 ...

The purpose of this short-term study is to determine whether pramlintide (Symlin) will help to reduce the frequency and severity of hypoglycemia in individuals

Neonatal hypoglycemia is when a baby is born and is unable to control its own blood sugars and frequently occurs in those born prematurely

First, lets look at your liver. Your liver makes and stores glucose (sugar). This glucose will be released when your body needs to raise your blood sugar levels. The liver also metabolizes, or breaks down, alcohol. When your liver breaks down alcohol, its glucose production is impaired.. Now lets look at medications you may be taking. Insulin and type 2 diabetes medications, like sulfonylureas (glipizide, glyburide) and metformin, decrease your blood sugar levels. Regular meals and a medication plan will help you keep your blood glucose at healthy levels. Habits like skipping meals can cause low blood sugar levels.. Combining already low blood sugar levels with alcohol-impaired liver function will put you at risk for dangerously low blood sugar levels, known as hypoglycemia . Hypoglycemia can occur shortly after drinking. The effect can continue for up to 24 hours afterwards. The symptoms of hypoglycemia and being drunk are similar-confusion, anxiety, and feeling faint. Be careful not to ...

Improved glycaemic control and reduced risk for hypoglycaemia in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion as compared to multiple daily insulin injections / vorgelegt von Stefanie Isabelle Kündig. - Zürich, 2009 ZB (Zürich) , UnS 2009: 841 , Magazin 05 - auf ...

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Background: Congenital Hyperinsulinism (CHI), a condition characterised by dysregulation of insulin secretion from the pancreatic beta cells, remains one of the most common causes of hyperinsulinemic, hypoketotic hypoglycaemia in the newborn period. Mutations in ABCC8 and KCNJ11 constitute the majority of genetic forms of CHI. Biallelic inactivating mutations (homozygous or compound heterozygous) in ABCC8 and KCNJ11 are known to result in severe, diffuse, diaxoxide unresponsive hypoglycaemia. We report a neonate with CHI due to compound heterozygous mutations in ABCC8 and completely responsive to diazoxide.. Case: A term macrosomic male baby, birth weight 4.81 kg, born to non-consanguineous parents, presented on day 1 of life with severe and persistent hypoglycaemia. Apart from polyhydramnios during the antenatal period, the pregnancy was otherwise uneventful. Normoglycaemia (blood glucose,3.5mmol/L) was achieved with a peak glucose infusion rate (GIR) of 20mg/kg/minute. The hypoglycaemia screen ...

Body Transformation: Defeating Diabetes reversible with a healthy lifestyle and proper nutrition. Certified Diabetes Educator Cde Salary Pre Ideas Breakfast insulin is a hormone produced by the pancreas that helps keep blood sugar under control. Gestational Diabetes: A sugar that is present in IME Ayurveda diabetes management kit. The standard and protein snacks resulted in no nocturnal hypoglycemia at all HS Looking for online definition of ketosis-prone diabetes mellitus in the The typical symptoms of diabetes ketosis-prone diabetes mellitus; ketosis Hypoglycemia Treatment :: Non Diabetic Hypoglycemia Diet Hypoglycemia Treatment :: What Are Some Of The Symptoms Of Diabetes We work with healthcare professionals to improve diabetes care management & monitoring Diabetes care for for care home residents with diabetes are Richards Curcumin Now Touted as a Significant Weight Loss & Disease Prevention Nutrient. time during pregnancy.. Home Types Of Diabetes Type 1 Diabetes Treatment Of Type 1 ...

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Erratum. Response to Comment on Pathak et al. Severe Hypoglycemia Requiring Medical Intervention in a Large Cohort of Adults With Diabetes Receiving Care in U.S...

Introduction: Nesidioblastosis is a hyperplasia of the beta cells that causes persistent hyperinsulinemic hypoglycemia, unfortunately, it is difficult to diagnose through imaging studies.Case presentation: A 68-year-old woman with palpitations, diaphoresis, dizziness and alterations in the level of consciousness that improve with food intake. Laboratories: glucose 35.0 mg/dl, insulin 12.5 mUI/ml, proinsulin 14.1 pmol/L and peptide C 2.55 ng/ml. Octreoscan reveals an abnormal epigastric uptake area and the tomography shows a focal hypervascular lesion in pancreatic body of 12×11 mm. A distal pancreatectomy was performed without palpating the tumor in transoperative period, and a diffuse nesiodioblastosis was reported in the histopathological study. The patient persists with hypoglycemia and an additional pancreatic resection was performed, resecting 90% of the organ. Although an insulinoma was not located in the piece, an area surrounded by connective tissue was observed where islet hyperplasia was more

Treatment for Low Blood Glucose Levels in Sion, Mumbai. Find Doctors Near You, Book Appointment, Consult Online, View Doctor Fees, Address, Phone Numbers and Reviews. Doctors for Low Blood Glucose Levels in Sion, Mumbai | Lybrate

Overdosage of sulfonylureas including glipizide can produce hypoglycemia. Mild hypoglycemic symptoms without loss of consciousness or neurologic findings should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood glucose at a level above 100 mg/dL. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Clearance of glipizide from plasma ...

Govt warns supplement may cause hypoglycemia The Yomiuri Shimbun (Major Japanese Newspaper) The health ministry is warning the public that a supplement called alpha lipoic acid, which is believed to be effective in reducing weight and slowing aging, may cause spontaneous hypoglycemia, a condition...

In 2013, a workgroup of the American Diabetes Association (ADA) and the Endocrine Society reconfirmed previously published criteria for the definition and

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Over the past years there has been a significant decrease in mortality and morbidity in patients suffering from severe burns due to improved burn wound management and approaches in critical care. Survival is no longer the exception, but unfortunately death still occurs. One of the key elements concerning state-of-the-art burn care is blood glucose control and insulin therapy; it is well known that burn-induced hyperglycaemia is associated with adverse clinical outcomes. However, controversy for insulin therapy and tight glycaemic control in critically ill and burn patients exists. The increased incidence of hypoglycaemia is the dominant argument against this treatment, because hypoglycaemia is also associated with an increased risk for death in critically ill patients. Taking all current data together, insulin therapy appears both a friend and a foe in the treatment of ICU patients. In order to overcome the limits of tight glycaemic control resulting from hypoglycaemic episodes, current efforts have

TY - JOUR. T1 - Trimethoprim-sulfamethoxazole-induced hypoglycemia as a cause of altered mental status in an elderly patient. AU - Mathews, W. A.. AU - Manint, J. E.. AU - Kleiss, J.. PY - 2000/12/1. Y1 - 2000/12/1. N2 - Even though drug-induced hypoglycemia is a rare event in the general population, it occurs more frequently in the elderly and in diabetic patients and thus should be considered in the differential diagnosis of altered mental status in these patient groups. In this case study, the authors describe a 91-year-old woman who was taken to the emergency department because of decreased consciousness while on a drug regimen that included once-daily triamterene-hydrochlorothiazide and twice-daily, double-strength trimethoprim-sulfamethoxazole (TMP-SMX). On arrival at the hospital, the patient had a plasma glucose value of 34 mg/dL along with an elevated creatine kinase level and a small tongue laceration. She was treated with a 50-mL ampule of 50% dextrose solution intravenously. She ...

Post-bariatric hypoglycemia is a profoundly life-altering condition for patients. Having unpredictable hypoglycemia that people cant detect is really an unsafe situation. Researchers at Joslin Diabetes Center and Harvard John A. Paulson School of Engineering and Applied Sciences have developed a closed-loop system that automatically provides patients with an appropriate, as-needed dose of liquid glucagon to treat this condition.

The links between hypoglycemia and Menieres disease have been studied for decades. Hypoglycemia as a cause of Menieres is debatable in that there are several possible causes and many contributing factors.