The purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate to severe Obstructive Sleep Apnea (OSA) that have failed or do not tolerate positive airway pressure (PAP) therapy.. ...
Definition: Hypoglossal nerve lesions are pathological processes which negatively affect the nerves function. Lesions affecting cranial nerve XII are uncommon. Causes: Causes of isolated Hypoglossal nerve palsies are rare but include: malignancies cerebrovascular accidents space occupying lesions head and neck trauma infection certain autoimmune pathologies Examination: Â Lesions affecting cranial nerve XII produces characteristic clinical manifestations, of which unilateral atrophy of the tongue musculature with deviation to the side of the lesion and fasciculations are the most easily appreciated. The hypoglossal nerve can be sub-divided into five segments; a different type of lesion may exist in any of these segments, therefore the diagnosis of such a lesion is greatly facilitated by the use of both computed tomography and/or magnetic resonance imaging.
Paralysis of the tongue can be a symptom of a heterogeneous spectrum of pathologies, and imaging of the potentially affected regions in the central and peripheral nervous system is an essential element of the diagnostic work-up. In case of a suspected lesion of the hypoglossal nerve, radiologic standards have been established. The medullary, cisternal, and skull base segments of the hypoglossal nerve course are examined with CT and MR imaging according to the strengths of these imaging modalities in imaging soft-tissue or bony structures. For the neck segment of the hypoglossal nerve, CT and MR imaging have also been advocated as the primary imaging modalities.19⇓-21 Here, the hypoglossal nerve is assessed indirectly by delineating the muscles innervated by the nerve and by detecting potential pathologies that are in the vicinity of the expected course of the nerve. Muscle atrophy or muscle denervation changes can indirectly indicate pathology of the hypoglossal nerve, but they are not direct ...
1. The jugular and superior ganglia of the vagus and glossepharyngeal nerves, the hypoglossal ganglia and ganglia of the spinal nerves arise in the pig embryo from a continuous neural crest, as observed by Streeter in human embryos. 2. The hypoglossal ganglia are retarded in their development, but appear in embryos of 13 mm. as a series of eight connected cell masses of nearly equal size. HYPOGLOSSAL GANGLIA OF PIG EMBRYOS 281 3. According to their development, the hypoglossal ganglia can be divided only artificially into a cephalic cerebral group and a caudal pre-cervical group. 4. The first cervical and other spinal ganglia are often of double origin, composed of two spindle-shaped masses, and generally possess two distal roots. 5. The spindle-shaped ganglion of Froriep with its single distal root would therefore represent but one half of a spinal ganglion. 6. The degree of development of the hypoglossal ganglia varies in different embryos; in the same embryo the right side may be better ...
The results from the Apnex feasibility trials have been published in three peer-reviewed publications in leading medical journals. The recent findings demonstrate how the HGNS System works and that the therapy can be effective in treating moderate-to-severe OSA. Access to the publication abstracts is available from PubMed by clicking the links below.. 1. Goding GS Jr, Tesfayesus W, Kezirian EJ. Hypoglossal Nerve Stimulation and Airway Changes under Fluoroscopy. Otolaryngol Head Neck Surg. 2012; 146(6):1017-1022.. 2. Schwartz AR, Barnes M, Hillman D, Malhotra A, Kezirian E, Smith PL, Hoegh T, Parrish D, Eastwood PR. Acute Upper Airway Responses to Hypoglossal Nerve Stimulation during Sleep in Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2012;185(4):420-426.. 3. Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, ODonoghue FJ, Rochford PD, Churchward T, Campbell MC, Palme CE, Robinson S, Goding GS, Eckert DJ, Jordan AS, Catcheside ...
oblongata houses a diverse number of vital nuclei reserved for the purpose of sensory relay and for the cranial nerves as well. Inside the fourth ventricle also lies the nucleus ambiguous and the Hypoglossal nucleus. It creates the central structure that brings the glossopharyngeal accessory and Hypoglossal nerves forth. The vestibular nuclei forms the vestibulocochear nerves, and on the ...
Authors: Ozsoy, Umut , Demirel, Bahadir Murat , Hizay, Arzu , Ozsoy, Ozlem , Ankerne, Janina , Angelova, Srebrina , Sarikcioglu, Levent , Ucar, Yasar , Angelov, Doychin N. Article Type: Research Article Abstract: Purpose: The outcome of severe peripheral nerve injuries requiring surgical repair (transection and suture) is usually poor. Recent work suggests that direct suture of nerves increases collagen production and provides unfavourable conditions for a proper axonal regrowth. We tested whether entubulation of the hypoglossal nerve into a Y-tube conduit connecting it with the zygomatic and buccal facial nerve branches would improve axonal pathfinding at the lesion site, quality of muscle reinnervation and recovery of vibrissal whisking. Methods: For hypoglossal-facial anastomosis (HFA) over a Y-tube (HFA-Y-tube) the proximal stump of the hypoglossal nerve was entubulated and sutured into the long arm …of a Y-tube (isogeneic abdominal aorta with its bifurcation). The zygomatic and buccal ...
The tongue is a very important muscle and holds countless clues for the neurologist. It is innervated by the last of the 12 cranial nerves, the hypoglossal nerve. which may be paralysed by a very localised stroke and this is often in the context of a condition called cervical artery dissection. This is a tear in one of the big arteries in the neck which take blood to the brain. The tear may arise from trivial neck movements and manipulations such as look up for a long time or staying too long on the hairdressers couch. A clot then forms at the site of the tear, and this then migrates to block a smaller blood vessel supplying the brainstem where the hypoglossal nerve sets off from…phew! Anyway, when this kind of stroke occurs, the tongue deviates to the the weaker side when it is poked out.. The more general weakness of the tongue is seen in conditions such as motor neurone disease (MND), in which the tongue also quivers at rest-something neurologists call fasciculations. The cheeky neurologist ...
The tongue is a very important muscle and holds countless clues for the neurologist. It is innervated by the last of the 12 cranial nerves, the hypoglossal nerve. which may be paralysed by a very localised stroke and this is often in the context of a condition called cervical artery dissection. This is a tear in one of the big arteries in the neck which take blood to the brain. The tear may arise from trivial neck movements and manipulations such as look up for a long time or staying too long on the hairdressers couch. A clot then forms at the site of the tear, and this then migrates to block a smaller blood vessel supplying the brainstem where the hypoglossal nerve sets off from…phew! Anyway, when this kind of stroke occurs, the tongue deviates to the the weaker side when it is poked out.. The more general weakness of the tongue is seen in conditions such as motor neurone disease (MND), in which the tongue also quivers at rest-something neurologists call fasciculations. The cheeky neurologist ...
Phasic bursting in the hypoglossal nerve can be uncoupled from phrenic bursting by application of positive end-expired pressure (PEEP). We wished to determine whether similar uncoupling can also be induced in other respiratory-modulated upper airway
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Hi all, new poster here. Hoping to find some guidance as my current Neurologist is stymied. Last year I was diagnosed with Bells Palsey. Very slight drooping of face, tongue went to left when stuck out. All returned to normal except tongue. Fast forward one year and it happened again! This time only affecting tongue, no facial drooping at all. I cannot move tongue up/down or left/right but I can stick it out. Again, it deviates to the left. Other symptoms when this happens is severe pain on
The aura6000 device is an implanted hypoglossal nerve stimulator designed to maintain wakeful muscle tone of the tongue during sleep. It is implanted through a short surgical procedure. The implant is programmed to provide the optimal stimulation parameters for the patient. The therapy is controlled by a hand-held remote control allowing the patient to start, stop, and pause the therapy during times of sleep ...
The aura6000 device is an implanted hypoglossal nerve stimulator designed to maintain wakeful muscle tone of the tongue during sleep. It is implanted through a short surgical procedure. The implant is programmed to provide the optimal stimulation parameters for the patient. The therapy is controlled by a hand-held remote control allowing the patient to start, stop, and pause the therapy during times of sleep ...
This page includes the following topics and synonyms: Cranial Nerve 12, Cranial Nerve XII, Hypoglossal Nerve, CN 12, Hypoglossal Nucleus.
The hypoglossal nerve, that is the twelfth cranial nerve innervating the muscles of the tongue, was damaged on the right side (left in the micrograph). The bodies of nerve cells are stained blue in the micrograph. Microglia are stained black. The cell bodies of the axotomized motor neurons (asterisk) are located left of the center of the section in an area called hypoglossal nucleus. Microglia (arrowhead) are gathered in great number among the axotomized motor neurons and wrap themselves around their bodies (arrow), detaching incoming nerve contacts known as synapses that convey command and control for muscle contraction from the fore brain. The motor neurons undergo chromatolysis and increase protein synthesis. David Bodian described the cellular changes using electron microscopy in great detail in the Johns Hopkins Hospital Bulletin (Bodian, 1964). Blinzinger and Kreutzberg (1968) were the first to identify the cells that insert themselves between the motor neuron and the synapses as ...
Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY, Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency, Scientific Reports, 7: ...
Dr. Mas Takashima will be the first sleep surgeon in Houston to perform the hypoglossal nerve stimulator procedure to treat sleep apnea.
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OJ is an unpaid advisor for ImThera medical and has received research funding support from ImThera Medical for the THN2 and THN3 FDA clinical trials. This topic discusses implantable hypoglossal neurostimulation devices and ImThera Medical is 1 of 3 companies in this field. Discussion is limited to available scientific evidence and there is no contractual agreement to disseminate product information. OJ is a consultant for Nyxoah Medical, which is developing a new implantable hypoglossal neurostimulation device. This device is not mentioned in the topic, as no published studies exist at the time of publication. The general topic is included in the topic. There is no contractual agreement to disseminate product information. ...
Especially made for very tiny babies, the Jessica Sleepsuit has plenty of room to move in and can be worn over other clothes.. Can also be created for toys and dolls.. Featuring an asymmetric opening which reaches from the neckline to the foot, the sleep suit is easy to get on and off.. Can be made with or without a hood and with or without feet. There are two patterns, one for a short foot (3-5cm) and one for a longer foot (6-8cm).. Sizes available in this pattern are: 24-36 týždne + gestational age. ...
Data preparation is the process of gathering, combining, structuring and organizing data so it can be analyzed as part of data visualization, analytics and machine learning applications.. ...
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Po dne n m m tinku Praga Academica t esk atletick nominace na ME, kter bude hostit Mnichov, dvaa ty icet jmen. Z vod na 400m vyhr l Jind ich im nek a asem 0:50:57 si zajistil letenku do Mnichova. Tot se o chv li pozd ji poda ilo v koula sk m sektoru Anton nu alsk mu v konem 19,17m. Po mate sk dovolen se vracej c v ka ka Zuzana Hlavo ov , zat m na pot ebn ch 192cm ek ...
Trendem dne n doby je vypadat mladistv a t hle. Proti tomu nelze nic nam tat, pokud to lov k nep eh n , nehladov a neabsolvuje jednu plastickou operaci za druhou. Na druhou stranu nen od v ci p rod ob as napomoci. Jednou z mo nost je estetick chirurgie.
Dnešní díl bylinkového seriálu věnujeme rostlině jménem ostropestřec. Je škoda, že tuto téměř dvoumetrovou bylinu u nás vidíme jen zřídka. Její výskyt se zvyšuje, avšak na svou slávu z 16. století bude muset asi ještě nějakou dobu počkat.
Jsou houby, kter d ky obsahu terapeuticky inn ch l tek, vyu vali lid po stalet k l en r zn ch neduh . V dne n dob se p stuj ve velk m. Hlavn v Asii i Spojen ch st tech, kde jsou dnes velmi popul rn . ...
Poverte dnešných študentov vytvorením sveta budúcnosti. Nájdite cenovo dostupné výučbové technológie a zdroje pre vašu školu a študentov.
The Cranial Nerves XI-XII Accessory Nerve and Hypoglossal Nerve. Dr. Zeenat Zaidi Dr . Essam Eldin Salama. Objectives . At the end of the lecture, the students should be able to: List the nuclei related to accessory and hypoglossal nerves in the brain stem. Slideshow 1863308 by sai
The lowest four cranialnervesHYPOGLOSSAL NERVEThe hypoglossal nerve (cranial nerve XII) contains somaticefferent fibers for the supply of the extrinsic and intrinsicmuscles of the tongue. Its nucleus lies close to the midline inthe floor of the fourth ventricle and extends almost the fulllength of the medulla (Figure 15.1). The nerve emerges as aseries of rootlets in the interval between the pyramid and theolive. It crosses the subarachnoid space and leaves the skullthrough the hypoglossal canal. Just below the skull, it liesclose to the vagus and spinal accessory nerves (Figure 15.2). Itdescends on the carotid sheath to the level of the angle of themandible, then passes forward on the surface of the hyoglossus muscle where it gives off its terminal branches.In the neck, proprioceptive fibers enter the nerve from thecervical plexus, to accept afferents from about 100 musclespindles in the same half of the tongue.Phylogenetic noteIn reptiles, the lingual muscles, the geniohyoid muscle, andthe ...
The tongue muscles form two distinct groups - extrinsic muscles, whose fibers arise outside of the tongue and then converge into the substance of the tongue, and intrinsic muscles, whose fibers are completely within the tongue. Both groups develop from the occipital somites at the base of the developing cranium. The ventral motor roots from the brainstem-spinal cord transition enter these somites to form the hypoglossal nerve, which innervates all of the tongue muscles. In general, the extrinsic muscles modify the position of the tongue, while the intrinsic muscles modify its shape. Tongue muscles do not act in isolation, but in varied combinations to produce the wide array of intricate tongue motions. These motions are essential for the acquisition, manipulation, and swallowing of food, and also play important roles in molding the vocal sounds, produced by the larynx, into the words we speak ...
The tongue muscles form two distinct groups - extrinsic muscles, whose fibers arise outside of the tongue and then converge into the substance of the tongue, and intrinsic muscles, whose fibers are completely within the tongue. Both groups develop from the occipital somites at the base of the developing cranium. The ventral motor roots from the brainstem-spinal cord transition enter these somites to form the hypoglossal nerve, which innervates all of the tongue muscles. In general, the extrinsic muscles modify the position of the tongue, while the intrinsic muscles modify its shape. Tongue muscles do not act in isolation, but in varied combinations to produce the wide array of intricate tongue motions. These motions are essential for the acquisition, manipulation, and swallowing of food, and also play important roles in molding the vocal sounds, produced by the larynx, into the words we speak ...
Randal C. Paniello. Introduction 189. RationaleforReinnervation in UVFP 189. ChoiceofDonorNerve 190. Choice of Anesthesia /. ContingencyPlans 191. Technique ofAnsa Cervicalis toRLNAnastomosis 192. Technique of Hypoglossal Nerve toRLNAnastomosis 193. PostoperativeCare 194. Results ofAnimal Studies 194. Clinical Results 195. Ansa-RLN 195. Ansa-RLN and Medialization 195. Hypoglossal Nerve 196. Original RLN 196. ReinnervationorMedialization? 197. Cricothyroid Reinnervation 197. AbductorReinnervation 198. Phrenic Nerve 198. Ansa Cervicalis 199. Combined Adductor and Abductor. Reinnervation 199. BidirectionalMotion:AnimalModels . ... 199 Reinnervation for Laryngeal. Transplantation 199. Conclusion 200. Chapter 12. Was this article helpful?. ...
Neurosurgery 69[ONS Suppl 2]:ons121-ons140, 2011. DOI: 10.1227/NEU.0b013e31822a547b. Schwannomas originating from the hypoglossal nerve are extremely rare. Microsurgical resection with the goal for cure has traditionally been associated with a high risk of postoperative deficits.. OBJECTIVE: To summarize our clinical experience using tailored cranial base approaches for these formidable lesions.. METHODS: The clinical records of 13 patients were retrospectively reviewed. In addition, all reported patients in the literature were reviewed. The extreme lateral infrajugular transcondylar-transtubercular exposure approach was used in all of our patients. Based on our experience and literature analysis, we propose the following modified grading scale to facilitate surgical planning: type A, intradural tumors; type B, dumbbell-shaped tumors; type C, extracranial tumors; and type D, peripheral tumors.. RESULTS: All 13 patients underwent total, near-total, or subtotal tumor resection. Eight patients were ...
Steffen F, Flueckiger M, Montavon PM. Vet Surg 2003;32:411-415. OBJECTIVE: To present a detailed description of a dog with atlanto-occipital (A-O) luxation,
Hypoglossal schwannomas are rare cranial base neoplasm arising from schwann cells of the XIIth cranial nerve. We report a case of 45 year old lady with history of headache for 2 years and difficulty in swallowing for 1 year.
Awalnya nervus hypoglossus terletak di inferior arteri karotis interna dan vena jugularis interna, dan terhubung dengan nervus vagus; kemudian nervus berjalan ke anterior di antara vena dan arteri, dan menuruni leher dan menjadi terletak superficial di inferior m. digastricus. Nervus kemudian membentuk lup mengelilingi arteri occipitalis, dan menyilang arteri karotis interna dan arteri lingualis di inferior tendon m. digastricus. Nervus berjalan di bawah tendon m. digastricus, m. stylohyoideus, m. mylohyoideus dan m. hyoglossus dan berhubungan dengan nervus lingualis di batas anterior m. hyoglossus. Nervus kemudian berjalan ke anterior hingga ujung lidah dan menginervasinya ...
An apparatus reduces the volume of selected sections of a tongue. The apparatus includes a catheter means. An electrode means is at least partially positioned in an interior of the catheter means. The electrode means is configured to deliver sufficient electromagnetic energy to ablate an interior of the tongue without damaging a hypoglossal nerve of the tongue. An electrode advancement and retraction means is coupled to the electrode means to advance and retract at least a portion of the electrode means in and out of a selected tongue surface. A cabling means is coupled to the electrode means.
An apparatus that reduces a volume of a selected site in an interior of the tongue includes a handpiece means and an electrode means at least partially positioned in the interior of the handpiece means. The electrode means includes an electrode means electromagnetic energy delivery surface and is advance able from the interior of the handpiece means into the interior of the tongue. An electrode means advancement member is coupled to the electrode means and configured to advance the electrode means an advancement distance in the interior of the tongue. The advancement distance is sufficient for the electrode means electromagnetic energy delivery surface to deliver electromagnetic energy to the selected tissue site and reduce a volume of the selected site without damaging a hypoglossal nerve. A cable means is coupled to the electrode means.
There has been a lot of recent controversy surrounding the experimental treatment in clinical trials known as GM604. A lot of misinformation has been tossed around on both sides of the issue. I want to beg your attention for a little while to explain whats really going on. First, as many of you know, I was the single late-stage PALS who received GM6 in compassionate use. The intent behind this was to get a look at differences in biomarker candidate levels between earlier-stage and late-stage PALS. Any outward physical manifestation of improved condition noticed would be a bonus and, due to my advanced condition, no improvement in condition was expected. Nevertheless, Genervon and I came up with the idea to try to chart improvements in the tongue. The rationale is that since my tongue is only moderately affected, and because the hypoglossal nerve contains one of the shortest motor neurons in the body, any possible improvement would be noticed there first.. Because of my growing cooperative ...
Figure 34.3 Diagram of the relationships between the lingual artery and nerve, submandibular duct, hypoglossal nerve and muscle ...
Definition of Nucleus nervi hypoglossi with photos and pictures, translations, sample usage, and additional links for more information.
Question - Feeling of obstruction in back of tongue, white-yellow crust on tongue. History of H. pylori and fungus. Ask a Doctor about diagnosis, treatment and medication for Fungal infection, Ask a Dentist
In English this muscles name is the muscle of the U-shaped bone and tongue. The term hyoid comes from its resemblance to the Greek letter upsilon (u), which is aspirated as hy. This is combined with the suffix eidos meaning "shape or form." The word glossa is Greek for "tongue ...
In English this muscles name is the muscle of the pillar and the tongue. The word styloglossus can be divided into the Greek words stylos meaning "pillar" and glossa meaning "tongue ...
Question - Had canker sore on tongue. Could have passed to my partner through oral sex?. Ask a Doctor about diagnosis, treatment and medication for Genital herpes, Ask a Sexual Diseases Specialist
Hi Dr. Yesterday I felt a sore lump on my tongue, it was red and raised a little. This morning I checked and the lump is still there but now all the little papules (is that the right word!?) are yell...
I have recently developed some discomfort on my tongue an I am worried that this can be a Herpes outbreak. I have not recently kissed anyone and I have never performed oral sex on anyone. I did have ...
First of all, I want to thank you for providing this very valuable service. So many times people are unable to get the answers they need from their own doctors. HISTORY: I had protected sex with a fem
Jedna z nejkr sn j ch her, co se mi kdy dostala do rukou. P edstavte si, e jste v dec a pracujete na ob m sticov m urychlova i. Jednoho dne p ijedete sv m autem do pr ce, zaparkujete p ed budovou a jdete dovnit . Na dne n den pl nujete experimenty s sticemi antihmoty. V klidu se posad te do sv ho k esla u po ta e, spust te urychlova a nic zl ho netu e si otev ete plechovku limon dy. V echno prob h , jak m . Co se d je venku v s v bec nezaj m . Jen e to je pr v chyba. Obrovsk bou ka zp sob tragickou nehodu urychlova e a vy jste vzniklou erv d rou p eneseni v ase a prostoru na zcela nezn m ciz sv t ...