BACKGROUND: Grading schemes for severity of suspected allergic reactions have been applied to the perioperative setting, but there is no scoring system that estimates the likelihood that the reaction is an immediate hypersensitivity reaction. Such a score would be useful in evaluating current and proposed tests for the diagnosis of suspected perioperative immediate hypersensitivity reactions and culprit agents.. METHODS: We conducted a Delphi consensus process involving a panel of 25 international multidisciplinary experts in suspected perioperative allergy. Items were ranked according to appropriateness (on a scale of 1-9) and consensus, which informed development of a clinical scoring system. The scoring system was assessed by comparing scores generated for a series of clinical scenarios against ratings of panel members. Supplementary scores for mast cell tryptase were generated.. RESULTS: Two rounds of the Delphi process achieved stopping criteria for all statements. From an initial 60 ...
Hypersensitivity reactions (HR) are immune responses that are exaggerated or inappropriate against an antigen or allergen. Coombs and Gell classified hypersensitivity reactions into four forms. Type I, type II, and type III hypersensitivity reactions are known as immediate hypersensitivity reactions (IHR) because occur within 24 hours. Antibodies including IgE, IgM, and IgG mediate them.[1]. Type I or Anaphylactic Response. Anaphylactic Responseis mediated by IgE antibodies that are produced by the immune system in response to environmental proteins (allergens) such as pollens, animal danders or dust mites. These antibodies (IgE) bind to mast cells and basophils, which contain histamine granules that are released in the reaction and cause inflammation. Type I hypersensitivity reactions can be seen in bronchial asthma, allergic rhinitis, allergic dermatitis, food allergy, allergic conjunctivitis, and anaphylactic shock.[2][3]. Anaphylaxis. Anaphylaxis is a medical emergency because can lead to an ...
Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with type I hypersensitivity, including cutaneous manifestations (e.g., urticaria and angioedema), respiratory manifestations (rhinitis, nasal polyposis, asthma), and anaphylaxis. To assess the sensitivity/specificity of in vitro tests for verifying the causative/tolerant drugs and cross-reactivity of different NSAIDs, we used three assays, including two ELISA tests for histamine/leukotriene C4 (LTC4) release, and a flow cytometric basophil activation test (BAT). We recruited 82 patients with NSAIDs-induced type I hypersensitivity (angioedema of the most cases), and isolated the peripheral leukocytes to perform histamine/LTC4 release tests in 38 patients, and BAT in 44 patients. The cell response to NSAIDs was examined in the incubation containing suspected or tolerant drugs with concentrations equal to 1-fold (physical level) or 10-fold Cmax. Comparing with the data of solve controls of the same subject, positive response was ...
Study Lecture 16 - Type I hypersensitivity - ALLERGY flashcards from M G's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Treatments for Type I Hypersensitivity including drugs, prescription medications, alternative treatments, surgery, and lifestyle changes.
Lee, Y.-L., Li, C.-W., Sung, F.-C., Yu, H.-S., Sheu, H.-M. and Guo, Y.L. (2007), Environmental factors, parental atopy and atopic eczema in primary-school children: a cross-sectional study in Taiwan. British Journal of Dermatology, 157: 1217-1224. doi: 10.1111/j.1365-2133.2007.08215.x ...
Health, ...The signs of atopy may be present long before symptoms begin even in ...The study appeared online in advance of the print publication of the A... We asked whether the allergic disease process may be active prior to ...The researchers measured the levels of u-EPX and several other markers...,Researchers,identify,early,biomarker,for,future,atopy,in,asymptomatic,children,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Contraindication:. CANDIN should not be used after a previous unacceptable adverse reaction to this antigen or to a similar product, i.e., extreme hypersensitivity/allergy.. Warnings and Precautions:. The antigen must be injected intradermally. Do not inject intravenously.. As has been observed with other, unstandardized, antigens used for DTH skin testing, it is possible that some patients may have exquisite immediate hypersensitivity to CANDIN.. Physicians using this product must have facilities, equipment and medication necessary to treat potential side effects. Epinephrine and oxygen must be immediately available in the event of a serious systemic response.. Adverse Reactions:. Immediate hypersensitivity local reactions can include itching, swelling, pain and blistering at the test site occurring 15-20 minutes after administration. Necrosis is possible.. Systemic reactions to CANDIN have not been observed, however all foreign antigens have the remote possibility of causing Type 1 anaphylaxis ...
Publication date: March 2018 Source: Oral Oncology, Volume 78 Author(s): Zeno A.R. Gouw, Jan Paul de Boer, Arash Navran, Michiel W.M. va ...
Targeted therapy of human malignant glioma in effectt mouse model by 2в5A antisense directed against telomerase RNA. Use your left hand to manipulate the phoropter or trial si.Shukla, N. A type I hypersensitivity response (immediate hyper- sensitivity or anaphylaxis) results from the production of IgE after exposure to an antigen.
The anti-inflammatory effect of Spirulina platensis (S. platensis) on induced cutaneous immediate-type hypersensitivity in dog was evaluated by using five healthy dogs. The experiments were consisted of 3 periods. At the first time, dogs were received nothing before induced cutaneous immediate-type hypersensitivity reaction using histamine and compound 48/80 intradermally. On the second time, dogs were received dry matter of S. platensis, which compose of phycocyanin being a major compound, for 10 days before they were performed the induction. Then dogs were withdrawn for 14 days, and received antihistamine drug (Hydroxyzine HCl) for 10 days before the induction was done. The immediate reaction was subjectively scored by measuring the diameters of the lesions in millimeters. Skin biopsies were performed and tissue sections were stained to determine the inflammatory cell infiltration and mast cell degranulation in each time of induction. Diameter sizes of wheal, numbers of inflammatory cell in ...
Background: Shuanghuanglian injection (SHLI) is a famous Chinese medicine used as an intravenous preparation for the treatment of acute respiratory tract infections. In the recent years, the immediate hypersensitivity reactions induced by SHLI have attracted broad attention. However, the mechanism involved in these reactions has not yet been elucidated. The present study aims to explore the characteristics of the immediate hypersensitivity reactions induced by SHLI and deciphers the role of the RhoA/ROCK signaling pathway in these reactions.Methods: SHLI-immunized mice or naive mice were intravenously injected (iv) with SHLI (600 mg/kg) once, and vascular leakage in the ears was evaluated. Passive cutaneous anaphylaxis test was conducted using sera collected from SHLI-immunized mice. Naive mice were administered (iv) with a single dose of 150, 300, or 600 mg/kg of SHLI, and vascular leakage, histamine release, and histopathological alterations in the ears, lungs, and intestines were tested. In vitro,
Coloured scanning electron micrograph (SEM) of the common environmental and allergenic mould (Cladosporium sp.); fungal hyphae producing spores. This genus is the most common airborne mould. Also known as Hormodendrum sp. This specimen was found on the inner surface of a buildings air supply duct. This genus is the most common outdoor airborne mould but may occur in homes. It is an allergenic mould producing over 10 different types of antigens. The spores are easily made airborne and are a common cause of respiratory problems. It is frequently found at elevated levels in water-damaged environments. Cladosporium can cause mycosis and extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include oedema and bronchospasms, chronic cases may develop pulmonary emphysema Cladosporium spp. can also be associated with the spoilage of refrigerated meats. Magnification: x340 when shortest axis printed at 25 millimetres. - Stock Image C032/3032
Scanning electron micrograph (SEM) of the common environmental and allergenic mould (Cladosporium sp.); fungal hyphae producing spores. Also known as Hormodendrum sp. This specimen was found on the inner surface of a buildings air supply duct. This genus is the most common outdoor airborne mould but may occur in homes. It is an allergenic mould producing over 10 different types of antigens. The spores are easily made airborne and are a common cause of respiratory problems. It is frequently found at elevated levels in water-damaged environments. The genus Cladosporium includes over 30 species. Cladosporium can cause mycosis and extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include oedema and bronchospasms, chronic cases may develop pulmonary emphysema Cladosporium spp. can also be associated with the spoilage of refrigerated meats. Magnification: x340 when shortest axis printed at 25 millimetres. - Stock Image C037/0677
Between July 2001 and May 2003, 187 mother and neonate pairs participated in this study. A total of 184 neonates completed the HLA-DR and -DQ genotyping. The frequencies of HLA-DR and -DQ genes, maternal sensitization, sIgE , 100 IU/ml, and cIgE ≥ 0.35 IU/ml were not different between the four areas. No association was found between cIgE and HLA-DR and -DQ genes or atopic symptoms. Physician diagnosed atopic symptoms were associated with the HLA-DQB1*02 allele (X2= 10.38, p,0.0013). After adjusting for possible potential risk factors, the sIgE , 100 IU/ml (Odds Ratio (OR) =5.01, 95% ci= [1.22, 27.14]), and HLA-DQB1*02 (OR = 8.09, 95% CI= [1.91, 36.74]) were risk factors for atopic symptoms in children at one year follow-up.. ...
When we think of "food allergy", we tend to think of someone who eats a food, such as strawberries, and breaks out in a rash or has difficulty breathing. This type of "immediate hypersensitivity" reaction is what most people think of when they hear "food allergy". It is only one type of food allergy and not even the most common type. Most food allergies are "delayed hypersensitivity" type in which symptoms appear anywhere from hours to days after eating the offending food. If the food is one you eat frequently, the repeated exposure can lead to a constant level of symptoms that begins to seem "normal". You may not even realize that you feel much better than you do ...
The medicines have side effects, another group of drug problems. Some of May, the side effects of medication errors, while others are a danger to the inevitable use of drugs in an appropriate manner. An example of a drug, the adverse reaction to a mistake is the use of aminoglycosides or other nephrotoxic drugs concomitant medication in patients with moderate renal insufficiency, which leads to a deterioration of renal function. The "error" component on the situation between gentamicin, if the therapy is not justified. Another example concerns the administration of a derivative of penicillin to a patient with a history of immediate hypersensitivity reactions.. A medication error to use a drug without examining a contraindication or a particular threat to individual cases. If your doctor is aware of contraindicated or who have a particular risk and makes a decision for the drug from the benefits and risks, so there is an error of drugs. Instead, all matters relating to the use of drugs is a side ...
The medicines have side effects, another group of drug problems. Some of May, the side effects of medication errors, while others are a danger to the inevitable use of drugs in an appropriate manner. An example of a drug, the adverse reaction to a mistake is the use of aminoglycosides or other nephrotoxic drugs concomitant medication in patients with moderate renal insufficiency, which leads to a deterioration of renal function. The "error" component on the situation between gentamicin, if the therapy is not justified. Another example concerns the administration of a derivative of penicillin to a patient with a history of immediate hypersensitivity reactions.. A medication error to use a drug without examining a contraindication or a particular threat to individual cases. If your doctor is aware of contraindicated or who have a particular risk and makes a decision for the drug from the benefits and risks, so there is an error of drugs. Instead, all matters relating to the use of drugs is a side ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Immediate hypersensitivity response to antigenic challenge, mediated by IgE and mast cells. It is a life-threatening allergic reaction, caused by the release of pharmacologically active agents. Anaphylactic shock can be utterly fatal ...
My oncologist switched me this week to taxotere because the numbness in my fingers wasnt going away. I didnt have an immediate allergic reaction like I did with taxol, although I had some insomnia the first night (Tuesday night) and today I overslept, probably because of the rain (It has been rainy here for weeks,…
A variety of Fc Receptor subtypes exist which display specificity for different isotypes of antibody. In most cases, Fc Receptors only bind antibody which is cross-linked with its antigen, guaranteeing that activation of phagocytes only occurs when the antibody is actually bound to a microbe. The primary exception to this is the Fc Receptor for IgE which can bind its antibody in the absence of antigen. The IgE Receptor is only expressed on anti-parasitic leukocytes such as Mast Cells, Basophils, and Eosinophils and plays a key role in the molecular pathogenesis of allergic responses (See: Type I Hypersensitivity ...
Twenty six infants with a congenital immunodeficiency, characterised by failure of their sera to opsonise heat killed bakers yeast for phagocytosis by normal polymorphonuclear leucocytes, were studied during infancy to determine the frequency of infection and development of atopy. They were compared with controls, matched prospectively for birth date, sex, parental smoking, and atopy and in whom feeding patterns were similar. In 18 of 26 infants the serum defect persisted at age one year. The incidence of infection and atopy, was appreciably greater in the study group than in controls. The 8 children in whom the defect was transient had a similar incidence of infection but a higher incidence of atopy than controls. Eight of 26 mothers and four of 9 fathers tested also had the serum defect, suggesting a strong genetic component. We support the hypothesis that immunodeficiency predisposes to infection and atopy, and that transient immunodeficiency predisposes to atopy.. ...
Background: The prevalence rate of asthma is increasing at an alarming rate worldwide and number of patients with asthma is projected to reach 100 mil..
Sorry for the long text: Dear Doctor! Im writing to you in connection with my girlfriends allergic reaction which happens when we are together. Basically she is already allergic to dust and has atopy on her right hand since
Of the 30,556 local workers in Wagga Wagga City, 27,029 or 88.5% also live in the area. Access in-depth demographics for Wagga Wagga City from the population experts, id.
The immunomodulatory effect of probiotics beyond atopy: an update. http://www.ncbi.nlm.nih.gov/pubmed/24256057 In the past decades, the theory of allergen avoidance was considered the standard treatment for preventing the onset of allergic diseases. Recently, the concept of immune tolerance has replaced this old theory, and induction of tolerance by exposure is actually considered the appropriate method for…
Because you were being a pretentious prick, do I really need to explain myself? - #87546695 added by youknowwhothisis at almost as fun
BACKGROUND: Cross-sectional studies have shown an association between the farming environment and a decreased risk of atopic sensitization, mainly related to contact with farm animals in the childhood. OBJECTIVE: Investigate the association of a farming environment, especially farm animal contact, during infancy, with atopic sensitization and allergic diseases at the age of 31. METHODS: In a prospective birth cohort study, 5509 subjects born in northern Finland in 1966 were followed up at the age of 31. Prenatal exposure to the farming environment was documented before or at birth. At age 31, information on health status and childhood exposure to pets was collected by a questionnaire and skin prick tests were performed. RESULTS: Being born to a family having farm animals decreased the risk of atopic sensitization [odds ratio (OR) 0.67; 95% confidence interval (CI) 0.56-0.80], atopic eczema ever (OR 0.77; 95% CI 0.66-0.91), doctor-diagnosed asthma ever (OR 0.74; 95% CI 0.55-1.00), allergic rhinitis at
Children were included in the current study if information on antibiotic exposure and at least 1 health outcome was available. History of maternal antibiotic use during pregnancy and breastfeeding was queried at home visits during pregnancy and after delivery. Postal questionnaires queried patient antibiotic exposure at 1 year and subsequently every 6 months until the age of 4 years. Biannual questionnaires also queried the diagnoses of eczema or recurrent wheeze in children. Atopic sensitization was assessed via Dermatophagoides pteronyssinus-, cat-, dog-, egg-, and cows milk-specific immunoglobulin E (IgE) at 1 and 4 years and birch- and timothy grass-specific IgE at 4 years. Atopic sensitization was defined as at least 1 positive specific IgE result. Parental D pteronyssinus-, cat-, dog-, birch-, timothy-, mugwort-, and Cladosporium herbarum-specific IgE were quantified. Gender, parental allergic history, parental educational level, pet exposure, tobacco use during pregnancy, birth weight, ...
Atopy (in 96%) and other clinical allergy (in 53 of the 55 atopic subjects) was a major feature. While common inhalant allergies were most common, it was striking that clear cut IgE mediated reactions, sometimes severe, to other foods occurred. Of other food allergies, egg allergy was commonest and usually presented with facial and laryngeal oedema and vomiting but sometimes with collapse. In the general population, about 40% are atopic (have positive results of skin prick tests to common inhaled allergens) and only about one third of these develop clinical allergy.15 In this study, the strong association with atopy and the fact that most atopic subjects were clinically allergic to common inhalant allergens suggests that peanut and nut allergy is occurring in a subpopulation with a strong propensity to develop allergies. There is probably a highly atopic at risk group, which could be identified in early childhood. Avoidance of the allergens during the period when sensitisation seems common, ...
Skin prick tests involve pricking an extract of a suspected allergen onto the surface of the skin. Redness and swelling at the test site indicate a Type I allergy, which is caused by the antibody IgE. This is currently the preferred method for diagnosing Type I allergies as it is relatively cheap, rapid, and provides visual proof of the allergy, which encourages patient compliance for future testing and therapy. Interestingly, the number of allergens recommended for testing varies between countries: European guidelines suggest testing 18 allergens and the US recommend between 10 and 50.. However, as recently debated in the World Allergy Organization Journal, there are several problems associated with skin prick tests. Various factors including age, body mass, medications, and skin conditions such as eczema can influence the specificity and sensitivity of this test. There is a very small risk that patients may suffer an anaphylactic reaction and there are some concerns that this test can actually ...
Dr. Bettina Wagner. The term allergy is commonly used to refer to several types of diseases that are caused by different forms of hypersensitivity reactions. Hypersensitivity immune responses directed against harmless antigens subsequently causing damage to host tissues. Depending on the immune mechanisms involved, hypersensitivity reactions are clustered in four types (I-IV). Type I hypersensitivities are mediated by a particular class of antibody known as Immunoglobulin E, or IgE. We will use the term allergy in this proposal to refer to type I hypersensitivities.. In the horse, only a few epidemiological studies about allergy exist in selected breeds. This reflects in our opinion the current difficulties to diagnose allergy rather than its absence. Most allergies are diagnosed by clinical signs only. The most common diagnostic test to identify allergic responses is intradermal skin testing with allergens, which is, however, mainly performed in larger clinics or universities, but rare in ...
Immune-Mediated Disorders of the Conjunctiva Hay Fever 10ggm and Perennial Allergic Conjunctivitis PATHOGENESIS Hay fever (seasonal) and perennial allergic conjunctivitis are largely IgE- mediated immediate hypersensitivity reactions. Elderm Cream 10gm the data were quite sparse, many pixels with missing values did not have enough neighbors inside the local window to allow the estimate of their value.
Olopatadine is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H1?antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells. Olopatadine is devoid of effects on alpha adrenergic, dopamine and muscarinic type 1 and 2 receptors. Following topical ocular administration in human, olopatadine was shown to have low systemic exposure.. ...
An immediate allergic reaction involves two actions of your immune system:. Your immune system produces immunoglobulin E (IgE), a specific class of antibody. IgE circulates through the blood and works against specific substances, but typically not against foods that we eat. A persons ability to form IgE specific to something as benign as food is an inherited predisposition. Generally, such people come from families in which allergies are common -- not necessarily food allergies, but perhaps hay fever, asthma, or hives. Someone with two allergic parents is more likely to develop food allergies than someone with one allergic parent.. The food-specific IgE then attaches to mast cells. These cells are in all body tissue, but are more often found near sites of allergic reactions, such as the nose, throat, lungs, skin, and gastrointestinal (GI) tract. ...
Atopy definition, an allergy, involving an inherited immunoglobulin of the IgE type, that predisposes a person to certain allergic responses, as atopic dermatitis. See more.
Delayed hypersensitivity reactions are inflammatory reactions initiated by mononuclear leukocytes. The term delayed is used to differentiate a secondary cellular response, which appears 48-72 hours after antigen exposure, from an immediate hypersensitivity response, which generally appears within 12 minutes of an antigen challenge.
TY - JOUR. T1 - Characteristics of atopic dermatitis in a post-childhood atopic March group. AU - Lee, Hemin. AU - Shin, Jung U.. AU - Lee, Jungsoo. AU - Chu, Howard. AU - Lee, Kwang Hoon. PY - 2017/2/1. Y1 - 2017/2/1. N2 - Background: Little knowledge is available on the characteristic differences between patients with atopic dermatitis (AD) with and without atopic March after childhood. Objective: To observe and compare the phenotypes of patients with AD in regards to atopic March tendency at a single point. Methods: We enrolled patients with AD aged between 10 and 30 years. The patients were divided into the atopic March and non-atopic March groups on the basis of an investigator-designed survey questionnaire, and their serum-specific immunoglobulin E (IgE) levels or results of the skin prick test were compared. Results: In a total of 182 patients enrolled in the study, 93 patients with atopic March and 89 patients with non-atopic March were observed. When meir serum-specific IgE levels or ...
In inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early l …
Health, allergy, allergiesAllergies (Type I Hypersensitivity) are actually a malfunction of our immune system that triggers our body to become hypersensitized and react immunologically to typically non-immunogenic substances. The substances that cause our bodies to become this way are called allergens. In 1906, Viennese pediatrician, Clemens von Pirquet, first coined the term "allergies" after he observed that certain symptoms of his patients might have been a response to outside allergens, like dust, pollen, or certain foods. Signs and SymptomsYou know your allergies are starting if you experience swelling in parts of your body. This is called local or systemic inflammatory response, caused by the presence of allergens. For instance, if your allergies affect you in the nose, you will experience swelling of the nasal mucosa (allergic rhinitis). During this condition, you will probably find yourself performing the "nasal salute" more than necessary as itching of your nose will induce you to wipe ...
Pregnancy is considered a Th2 state65 and there is some evidence that the neonatal immune response is biased toward the Th2 type. If a neonatal Th2 bias exists, it is not clear whether it represents persistence of the Th2 state of pregnancy or an immune system which has not yet encountered sufficient antigenic stimulation. Neonatal CD4+ T cells are similar to naive adult T cells in their ability to release sufficient IL-4 at priming to support clonal expansion into Th2 cells.153 154 However, naive cord blood T cells are much more responsive than adult naive T cells to IL-4 stimulation, a characteristic which might help to promote a Th2 immune response in neonates.135 A Th2 bias may be more pronounced in infants with family histories of atopy or in infants who subsequently develop allergic manifestations. Allergen specific T cell clones generated from CBMC of newborn infants with atopic parents produced more IL-4 and IL-5 than T cells from those with non-atopic parents; enhanced Th2 cytokine ...
Between 2010 and 2013, between the ages of four and eight, my daughter Sammi had ten endoscopies. Each time, she fasted from dinner the night before until after her morning procedure. Each time, they held a gas mask over her face in the operating room until she fell asleep, and then, after escorting me out of the room, they inserted an IV with heavier anesthesia and fluids, took a blood sample, inserted a mouthpiece and fed a camera down into her esophagus. They took pictures and they took biopsies - tiny pieces of her esophagus to test for the presence of eosinophils, the white blood cells whose functions, according to Cincinnati Childrens Hospital, include. movement to inflamed areas, trapping substances, killing cells, antiparasitic and bactericidal activity, participating in immediate allergic reactions, and modulating inflammatory responses. Ten times. They did that to her ten times in just over three years. They did that because she was still experiencing the symptoms of GERD - also known ...
To determine if your child has allergies, your doctor might recommend a skin prick test that involves piercing the skin with small drops of allergens.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The immune system exists to protect the host against pathogenic organisms and highly complex pathways of recognition, response, elimination and memory have evolved in order to fulfil this role. The immune system also acts to ensure tolerance to self, to food and other environmental components, and to commensal bacteria. A breakdown in the tolerogenic pathways can also lead to inflammatory diseases. The prevalence of inflammatory diseases, including atopic disorders, has increased over the last 60 years. The development of tolerance is the result of active immune mechanisms and both development and maintenance of tolerance are lifelong processes which start very early in life, even prenatally. Profound immunologic changes occur during pregnancy, involving a polarization of T helper (Th) cells towards a dominance of Th2 and regulatory T cell effector responses in both mother and fetus. This situation is important to maintain pregnancy through avoidance of the rejection of the immunologically ...
When cells are stressed, they initiate a complex and precisely regulated response to prevent permanent damage. One of the immediate reactions to stress signals is a reduction of protein synthesis ...
Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In ...
It has been proposed that increased production of IgE, a feature of atopy, is a cause of the non-specific bronchial hyper-reactivity that is characterisitc of asthma. This hypothesis was examined by selecting groups of subjects with asthma or rhinitis and a group of healthy control subjects and studying the relationship between their bronchial histamine reactivity and their atopic status. In none of the groups tested was there a significant association between the degree of bronchial histamine reactivity and either the serum level of total IgE or the number of extracts of aeroallergens giving positive prick test reactions.
In this study altered immune response as measured by total serum IgE level among symptomatic HIV infected patients, asymptomatic HIV positive individuals and healthy controls with and without helminths co-infection and the impact of deworming and/or ART on these immune activation was assessed within defined groups of population from tropical settings of Ethiopia where both HIV and helminths infections are common. Consistent with the earlier suggestions [25-27] that Africans generally present with elevated total serum IgE levels and our previous observations [14-16], patients in this study also showed a high total serum IgE level as shown by more than three-folds of the total IgE above the reference ranges irrespective of HIV and helminths co-infections. The highly significant correlation between helminth egg intensity and serum IgE level may partly explain the elevated total serum IgE levels observed in sub-Saharan regions, where heavy helminthic infections are widespread [14-16, 25-27]. It ...