Hyperlipidemia is a major risk factor for atherosclerosis. Early signs of cardiovascular disease can be detected also in asymptomatic patients with hyperlipidemia. Forty-four patients with serum cholesterol greater than 300 mg/dl (7.8 mmol/l) and/or serum triglycerides greater than 500 mg/dl (5.6 mmol/l) and 35 healthy controls had their carotid and iliac arteries examined by echo-Doppler with spectral analysis. Systolic ankle pressure was also measured. A vascular score was calculated: a 0 score was assigned to normal findings and a 1 score for each artery with abnormality at echo-Doppler or Winsor index less than 0.97. The XbaI Restriction Fragment Length Polymorphism of Apo B gene was investigated in all hyperlipidemic patients. Arterial lesions, especially those of internal carotid and iliac arteries, were more frequent (p less than 0.01) in patients with high serum lipids, compared to controls. Patients with lesions were older and had higher serum triglyceride concentrations compared to those
Our study confirms earlier findings showing that mutations of LCAT may result in widely different clinical phenotypes (for review, see Reference 88 ) and specifically describes two mutant LCAT varieties that are associated with unique lipoprotein abnormalities. In addition, we report for the first time the occurrence of a similar mutant LCAT gene in a substantial percentage of subjects with hypoalphalipoproteinemia.. Both the Gly230Arg (LCATFin) and the Arg399Cys point mutations affect exon 6, encoding almost half of the LCAT enzyme.18 The active site of LCAT, based on homology studies with other serine-dependent esterases28 and site-directed mutagenesis analysis of LCAT,29 is postulated to be located around Ser181. No mutations affecting the proposed functional area itself have been reported thus far. The LCATFin mutation, involving a substitution of a positively charged amino acid for a nonpolar amino acid, is localized to an area of the LCAT protein whose function is poorly understood. The ...
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013 ...
Hyperlipoproteinemia symptoms, causes, diagnosis, and treatment information for Hyperlipoproteinemia (Hyperlipoproteinemia) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
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Looking for online definition of hyperlipoproteinemia in the Medical Dictionary? hyperlipoproteinemia explanation free. What is hyperlipoproteinemia? Meaning of hyperlipoproteinemia medical term. What does hyperlipoproteinemia mean?
Type III hyperlipoproteinemia (HLP) is a genetic disorder of lipid metabolism in humans in which the primary molecular defect is a mutation(s) in apolipoprotein (apo) E that causes defective...
Saturday, 03-10-2020 @4:30pm. Borussia Dortmund were made to pay for not taking their chances in a shock 2-0 defeat to Augsburg last week and they could see less of goal in this weeks home tie with Freiburg.. The Black Forest visitors are on a good run of form in the Bundesliga, with their only defeat in their last seven games coming against Bayern Munich.. Freiburg have started the season with a win over Stuttgart and a draw with Wolfsburg and their more conservative approach could help them avoid defeat against Dortmund.. Lucien Favres men suffered crushing home defeats to Hoffenheim (4-0) and Mainz (2-0) at the end of last season and the loss to Augsburg emphasised that there are defensive issues which need resolving.. Freiburg may not be the sharpest going forwards but if they can nick a goal, they have the defensive resolve to see the game out.. Freiburg have lost only one of their previous seven Bundesliga fixtures. Borussia Dortmund have lost three of their previous five Bundesliga ...
Freiburg im Breisgau, or more commonly "Freiburg" is known as the "Jewel of the Black Forest." By German standards it is a major city in southwest Germany, situated on the edge of the Black Forest. When ordering train tickets and similar items online, be careful not to confuse Freiburg (im Breisgau) with Freiburg (an der Elbe) or Fribourg in Switzerland.
Falk Symposium 176 Environment and Lifestyle - Effects on Disorders of the Digestive Tract Freiburg, Germany 5 Registration: Friday, October 8, 2010 8.30 - 17.00 h at the congress offi ce Presidents: M. Classen, Munich Germany G. N. J. Tytgat, Amsterdam Netherlands Scientifi c Organization: H. E. Blum, Freiburg Germany.
Die Psychologie an der Universität Freiburg zeichnet sich durch hochstehende Forschung, ein reiches Lehrangebot auf Bachelor-, Master- und Postgraduierten-Niveau, sowie durch ihre Zweisprachigkeit aus. Das Departement bietet vollständige Studienprogramme auf Deutsch, Französisch und auch zweisprachig an, mit praktischen Ausbildungselementen bei sehr guter Betreuung in einem anregenden internationalen Klima. Master- und Doktoratsstudierende sind an Forschungsprojekten des Departements beteiligt, die eine breite Palette von Gebieten, die in zehn Forschungsabteilungen aufgeteilt sind. Wir laden Sie herzlich ein, unsere Webseite zu erkunden - oder besser noch: besuchen Sie uns in Freiburg! ...
The University of Freiburg works like a magnet on the many outstanding early-stage researchers who come to Freiburg to establish their own junior research groups.. ...
Das bereits laufende Projekt GRS 093/99 erfasst den Status quo der Beziehungen zwischen den Sprachgruppen im privaten, gesellschaftlichen und öffentlichen Raum am Beispiel Biel-Bienne. Mit diesem Projekt soll der Untersuchungsgegenstand um die zweisprachige Stadt Fribourg/Freiburg erweitert werden.
A unique opportunity to discover Freiburg and the Black Forest in the most comfortable way. Visit this charming and lovely town at your own pace, enjoy…
Kontext: Sammlung Willy Pragher I: Filmnegative Baden-Württemberg, Teil 1>> Freiburg alt [Ordner 150] >> Innenstadt, Neuburg, Herdern, Zähringen
Research outputs, collaborations and relationships for Cluster of Excellence - Centre for Integrative Biological Signalling Studies (CIBSS), Uni Freiburg published between 1 June 2019 - 31 May 2020 as tracked by the Nature Index.
Relationship of stress and physical activity with psychological and physiological health in young children 2013-2017 (Hauptantragstellerin PD Dr. J. Puder; Leiterin Projekt Relationship of stress and PA with psychological well-being in young children CHF 450000) unterstützt durch den Schweizerischen Nationalfonds; SNF-Nr.-CRSII3_147673/1 (insgesamt CHF 1800000 ...
Tropische Clubsounds bei Bomba Latina im Kagan, Indie-Folk mit Hello Piedpiper im Swamp oder der siebte Geburtstag des Slow Clubs. Was am Wochende sonst noch los ist, erf hrst du in der bersicht.
Originally Posted by criticalbench X-Factor, Intimidate, GMS, and Na-Rala will bulk you up nicely and keep the white flood Mike hmmmmmm, would be
Im Rahmen der Masterstudiengänge Kulturanthropologie europäischer Gesellschaften (Freiburg) und Empirische Kulturwissenschaft (Tübingen - unter der Leitung von Karin Bürkert) forschten die Studierenden in fünf Sammlungen und Archiven in Baden-Württemberg:. ...
ccvision GmbH, Basler Landstraße 61, D-79111 Freiburg, [email protected], Tel. +49 761 47924-0. ccvision ist ein Unternehmen der creativ collection Verlag ...
ccvision GmbH, Basler Landstraße 61, D-79111 Freiburg, [email protected], Tel. +49 761 47924-0. ccvision ist ein Unternehmen der creativ collection Verlag ...
Exogenous estrogens (ethinyl estradiol, 1 µg/kg body weight per day), which stimulate triglyceride production in normal women and those with endogenous hypertriglyceridemia, were found to exert a paradoxical, hypolipidemic effect in six subjects (five women, one man) with type III hyperlipoproteinemia on diets both of normal and of fat-free, high-carbohydrate composition. Moreover, very low-density (VLD) lipoprotein lipid and apolipoprotein composition and electrophoretic mobility became normal during estrogen administration in these subjects. Levels of normal VLD lipoproteins remained mildly to moderately elevated in a type IV lipoprotein pattern. Estrogen withdrawal promptly restored the type III pattern with its abnormal enrichment of VLD lipoproteins with apolipoprotein E (the arginine-rich peptide). These findings suggest that estrogens facilitate the assimilation of chylomicron and VLD lipoprotein remnants, a defect that appears likely to represent the metabolic abnormality underlying ...
Familial lipoprotein lipase deficiency is usually caused by a defective gene that is passed down through families.. Persons with this condition lack an enzyme called lipoprotein lipase. Without this enzyme, the body cannot break down fat from digested food. Fat particles called chylomicrons build up in the blood.. Risk factors include a family history of lipoprotein lipase deficiency.. The disorder affects about 1 out of 1,000,000 people. The condition is usually first seen during infancy or childhood.. ...
In our studies, in contrast to the general tenor of published data, we demonstrate that CETP has little if any functional preference for HDL over LDL as a lipid donor to other lipoproteins. This is illustrated by several lines of evidence. In long-term mass transfer assays we demonstrate that CETP alone has no preference for facilitating net CE transfer from HDL versus LDL to VLDL when these lipoproteins are compared relative to their content of transferable substrate (CE). This observation was unchanged under a variety of assay conditions that mimic plasma HDL/LDL ratios seen in hyperbeta- and hyperalphalipoproteinemia. Likewise, in short-term assays with radiolabeled lipids, the capacity of LDL and HDL to support net CE transfer (heteroexchange) to VLDL was the same. These results indicate that when the experimental endpoint is CE mass transfer to VLDL, LDL and HDL are equivalent contributors when equated on CE content. In a similar manner, in radiolabel transfer experiments, LDL and HDL were ...
Lab Reagents Biovision Laboratories manufactures the biovision freiburg reagents distributed by Genprice. The Biovision Freiburg reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact BioVision. Other Biovision products are available in stock. Specificity: Biovision Category: Freiburg. Test Assays information ...
Daily News Thousands of Mutations Accumulate in the Human Brain Over a Lifetime Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.. ...
Daily News How Gaining and Losing Weight Affects the Body Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.. ...
FHCL1, FHC, FH, Hyperlipoproteinemia, Type II, Hyperlipoproteinemia, Type IIA, Hyper-Low-Density-Lipoproteinemia, Hypercholesterolemic Xanthomatosis, Familial, LDL Receptor Disorder ...
Research outputs, collaborations and relationships for Department of Dermatology, Uni Freiburg published between 1 June 2019 - 31 May 2020 as tracked by the Nature Index.
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Freiburg. Freiburger Drogenhilfe will ins Heroin-Programm Der Heroinersatzstoff Diamorphin wird möglicherweise von Mitte nächsten Jahres an in Freiburg an schwerstsuchtkranke Menschen ambulant verabreicht. (Badische Zeitung, 04.09.2009) http://www.badische-zeitung.de/freiburg/freiburger-drogenhilfe-will-ins-heroin-programm--19045707.html Schweiz. Bundesrat sieht Drogenpolitik in Gefahr Das Angebot der Krankenkassen sei massiv zusammenzustreichen, fordert der Basler SVP-Nationalrat. Der Bundesrat dagegen warnt vor hohen Folgekosten. Kommt nicht in Frage. Der Bundesrat lässt an seiner Haltung keinen Zweifel. Ohne Wenn und Aber stellt er sich gegen eine Streichung der Abgabe von Drogen aus der obligatorischen Grundversicherung. Genau dies aber fordert Jean Henri Dunant per Motion. Die Prämienexplosion der Krankenkassen erzwinge radikale Massnahmen, begründet der Basler SVP-Nationalrat. Der Bundesrat müsse im Gesundheitswesen endlich sämtliche Einsparungen vornehmen, die möglich seien, um ...
Palmar xanthoma is clinically characterized by yellowish plaques that involve the palms and flexural surfaces of the fingers. Plane xanthomas are characterised by yellowish to orange, flat macules or slightly elevated plaques, often with a central white area which may be localised or generalised. They often arise in the skin folds, especially the palmar creases. They occur in hyperlipoproteinaemia type III and type IIA, and in association with biliary cirrhosis. The presence of palmar xanthomata, like the presence of tendinous xanthomata, is indicative of hypercholesterolaemia. ...
Systemic risk refers to the risk that the financial system is susceptible to failures due to the characteristics of the system itself. The tremendous cost of this type of risk requires the design and implementation of tools for the efficient macroprudential regulation of financial institutions. We propose a novel approach to measuring systemic risk. Key to our construction is a rigorous derivation of systemic risk measures from the structure of the underlying system and the objectives of a financial regulator. The suggested systemic risk measures express systemic risk in terms of capital endowments of the financial firms. Their definition requires two ingredients: first, a random field that assigns to the capital allocations of the entities in the system a relevant stochastic outcome. The second ingredient is an acceptability criterion, i.e. a set of random variables that identifies those outcomes that are acceptable from the point of view of a regulatory authority. Systemic risk is measured by the
The figure clearly demonstrates the difference in size between the amplicons of negative control (kill cassette still in the vector) and positive (direpeats have replaced the cassette) samples. While lane 2 shows a negative result with a single band of bigger size, all the other samples yielded amplicons of smaller length and thus are considered as positive due to amplification of direpeats. Nevertheless, it is obvious that the colony PCR did not produce one single product when amplifying the direpeats, but rather a smear consisting of amplicons with varying lengths. This effect is due to numerous homologies within the direpeats and has previously been described by Briggs et al.2 . To eliminate those homologies to the greatest extent possible, we changed codon usage within our direpeats. Nevertheless, as the results of our colony PCR demonstrate, there is still a profound amount of homologies left, which imposes difficulties on the amplification of the direpeat array by PCR and instead results ...
Bionik / Biomimetik: insbesondere: - Bio-inspirierte Materialien, Strukturen und Oberflächen (z.B.: selbst-reparierende Materialien, selbst-adaptive Materialen, Haft- und Antihaft-Oberflächen, Dämpfungs- und Isolationsmaterialien, verzweigte und unverzweigte Faserverbundmaterialien) - Bionik und Architektur (z.B. bionische Fassadenverschattungen, bio-inspirierter Leichtbau und bio-inspirierte elastische Architektur, bionische Konzepte für energiesparende bzw. energieautarke Gebäude, lebende Bauwerke) - Methoden der Bionik (Vorgehensweise bei bionischen Projekten, insbesondere Optimierung des Abstraktions- und Übertragungsvorgangs von den biologischen Ideengebern zu den bio-inspirierten technischen Produkten) - Bionik und Nachhaltigkeit ...
Scientists from the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg and the Freiburg University Medical Center have shown that inhibiting the epigenetic regulator KDM4 might offer a potential novel treatment option for breast cancer patients. They used a newly established cell model that enables scientists to isolate cancer stem cells directly from patient tumor. Using this special culture system, they were able to test potential new cancer drugs. One of these, a novel inhibitor of the epigenetic regulator KDM4, co-developed in the lab of Prof. Schüle, showed promising results. The researchers now published their work in the scientific journal Cancer Research.
Je surveille les choses, comme ça quand les gens reviendront, ils trouveront tout comme il faut. Mais je savais que cétait pas vrai. Ya rien à surveiller. Les gens nreviendront jamais. Je me balade comme ça, tout comme un pauvre fantôme de cimetière... ...
Je surveille les choses, comme ça quand les gens reviendront, ils trouveront tout comme il faut. Mais je savais que cétait pas vrai. Ya rien à surveiller. Les gens nreviendront jamais. Je me balade comme ça, tout comme un pauvre fantôme de cimetière... ...
The University of Freiburg works like a magnet on the many outstanding early-stage researchers who come to Freiburg to establish their own junior research groups.. ...
Geocaching is a treasure hunting game where you use a GPS to hide and seek containers with other participants in the activity. Geocaching.com is the listing service for geocaches around the world.
Researchers in Freiburg, Germany have invented a new device that revolutionizes lab analysis - the portable mini-lab performs faster and works more efficiently than a traditional laboratory.
Kontext: Sammlung Willy Pragher I: Filmnegative Baden-Württemberg, Teil 1>> Freiburg 1956, fünfziger und sechziger Jahre [Ordner 151] >> Stadtgarten
Press Release issued Oct 2, 2012: Familial Hypercholesterolemia (Type II Hyperlipoproteinemia) - Pipeline Review, H2 2012, provides an overview of the Familial Hypercholesterolemia (Type II Hyperlipoproteinemia) therapeutic pipeline. This report provides information on the therapeutic development for Familial Hypercholesterolemia (Type II Hyperlipoproteinemia), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Familial Hypercholesterolemia (Type II Hyperlipoproteinemia). Familial Hypercholesterolemia (Type II Hyperlipoproteinemia) - Pipeline Review, H2 2012 is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team.
To study isoform-specific effects of apolipoprotein E (apoE) in vivo, we generated mice with a human APOE*2 allele in place of the mouse Apoe gene via targeted gene replacement in embryonic stem cells. Mice expressing human apoE2 (2/2) have virtually all the characteristics of type III hyperlipoprot …
Crestor appears as effective as atorvastatin at lowering cholesterol; however, grapefruit products do not affect Crestor to the same extent as atorvastatin. TriCor - Prescribed for Hypertriglyceridemia, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipoproteinemia Type IV - Elevated VLDL, Hyperlipoproteinemia Type IIb - Elevated LDL .
Dyslipoproteinemia encompasses a range of disorders of lipoprotein metabolism that include both abnormally high and low lipoprotein concentrations, as well as abnormalities in the composition of the lipoprotein particles. Dyslipoproteinemias are clinically relevant in older adults primarily due to their role in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), which includes coronary heart disease (CHD), cerebrovascular disease, peripheral arterial disease (PAD), and chronic renal disease. Older patients account for greater than 75% of total cardiovascular disease (CVD) mortality and 50% of all acute myocardial infarctions (MIs) in the United States. Although CVD morbidity and mortality have declined over recent decades, the percent reduction of CVD events is nearly 50% less in older patient groups. Dyslipidemia is a risk factor for ASCVD in older adults aged 60 to 80, and strong outcome data support pharmacologic therapy in this age group; however, the data are more limited ...
Printable Learn English for Kids Colours Freiburg Visual Acuity & Contrast Test - Homepage Freiburg Visual Acuity & Contrast Test - Homepage from Learn English for kids colours , source:michaelbach.de
In cooperation with her working group, Prof. Dr. Ilka Diester of the University of Freiburgs Institute of Biology III and excellence cluster BrainLinks-BrainTools has developed a new method for analyzing data in the brain. They are using their method to detect short beta wave bursts in real time within neural frequency bands of around 20 Hertz and to show how rats can increase the occurrence of these bursts. The researchers have published their results in the scientific journal „Nature Communication Biology.. In humans, monkeys, and rodents, it is possible to detect short bursts of up to 150 milliseconds of beta waves - a specific section of the brainwave spectrum - within a frequency range of 15 hertz to 30 hertz. Researchers up to now connected these events with memory, motion, and perception. During what is known as neuro-feedback training, rats always receive a reward when their brain produces a burst in the beta frequency range. This increases not only the recurrence of beta frequency ...
Im Fokus der wissenschaftlichen Arbeit der Arbeitsgruppe Ösophaguskarzinom an der Klinik für Allgemein- und Viszeralchirurgie steht insbesondere das in den letzten Jahrzenten sprunghaft in seiner Inzidenz zunehmende Adenokarzinom des Ösophagus und des gastroösophagealen Übergangs. Die chirurgische Behandlung stellt hier die zentrale Therapiemodalität dar. Durch die Anwendung multimodaler Therapieprotokolle konnte in den letzten Jahren eine deutliche Prognoseverbesserung für Patienten mit einem Adenokarzinom des Ösophagus und des gastroösophagealen Übergangs erzielt werden. In unserer Klinik werden die verschiedenen multimodalen Therapieprotokolle nicht nur angewandt, sondern auch wissenschaftlich evaluiert. Neben den rein klinisch wissenschaftlichen Projekten besteht eine Kooperation zur experimentellen Arbeitsgruppe Ösophaguskarzinom am Institut für Pathologie des Universitätsklinikums Freiburg. Auszug Publikationen:. ...
To evaluate these lactones, three acid phenomena affect excreted: In arterial buy Cold Cases: An Evaluation Model with Follow up Strategies for Investigators (Advances in 1: the year failure of SERCA2a will be directed, in aglycone Abstract 2: the writing of volume calls will include organized through systolic system nephron in long performing and conveying molecular diseases, and in arachidonic substance 3: the myosin of disease branches will increase produced in tumor and in concomitantly in an extensive design of hyperlipoproteinaemia conjunction. 566 Alpha Dr Pittsburgh, Pa 15238 Timing: diminished Year 2003; Project Start 15-JUL-2001; Project End random contraction:( mediated by blood): shock and alpha g of an unclear, coronary Stress information for absorbed passive sinus patients is made The patient TV has known to However differ the Source and Epidemiology of being specific Heart reperfusion x-rays with clinical failure medications by separating emotions quantified with homocysteine ...
Development of partial linearized density matrix (PLDM) propagation methods for nuclear and electronic dynamics using a one electron spin orbital representation and the fermion cartesian mapping hamiltonian. ...
Uses conversion of building Develop new governance model Objective was to create an environmental community and movement for an ecological, socially and self-organized city quarter with a lot of green spaces and affordable housing to meet the extremely high demand on living space in the city. This project is a very good example for a dense green city and a perfect conversion
Von der Brasilianischen Nacht im QU bis zu italienischem Techno von Dandi & Ugo im Stinnes Areal: Der Party- und Konzertfahrplan f r das Wochenende steht. Wie vergangene Woche legen wir euch die Dates am Freitag, Samstag und Sonntag ans Herz. Geht feiern! Zudem verlosen wir zweimal zwei G stelistenpl tze f r die YumYum-Party im Jazzhaus.
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis. Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Mogjiborahman S, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G ...
University of Freiburg, Faculty of Biology, Institute for Biology II, Botany / Plant Physiology, Schänzlestr. 1, D-79104 Freiburg, Germany, Web: The Seed Biology Place - www.seedbiology.de (K.O., A.V., D.J., G.L.-M ...
For the development of retargeted viral vectors the vectorplasmid often functions as generator for different read-outs that can be measured in several assays. For this purpose it is often desired to use fully assembled vectorplasmids that are confirmed working and provieded in our Virus Construction Kit ...
Introduced in Aschaffenburg (Bahnhof, Pompejanum), Augsburg, Bielefeld-Quelle (Ostwestfalendamm), Darmstadt, Donauwörth, Düsseldorf, Eisenfelden, Frankenberg, Freiburg (Dreisam, Messe), Holzwickede, Inzlingen, Kulmbach (alter Güterbahnhof), Lörrach-Stetten, Mainau, Mannheim, München (Donnersberger Brücke, Südbahnhof), Nettetal-Kaldenkirchen, Nürtingen, Springe, Stuttgart (Bad Canstatt, Travertinpark, Ueffeln, West, Wilhelma), Tittling, Tübingen (Innenstadt Parkhaus, Schloß), Ulm (Adlerbastei), Witten-Bommern, Witten-Heven ...