Looking for Epidermolytic hyperkeratosis? Find out information about Epidermolytic hyperkeratosis. Hypertrophy of the cornea. Hypertrophy of the horny layer of the skin. excessive development of the corneous layer of the skin in humans. Hyperkeratosis may... Explanation of Epidermolytic hyperkeratosis
... refers to hereditary skin disorders that are characterized by varying degrees of blistering and subsequent reactive scaling of the skin. Depending on the nature of the causative mutation, the symptoms may vary from mild blistering upon friction to severe erosions or widespread warty scaling...
There are many different things that you can do to manage epidermolytic hyperkeratosis, including keeping your skin moisturized...
|p|The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.Keratin 1 is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.|/p|
TY - JOUR. T1 - Gene Editing-Mediated Disruption of Epidermolytic Ichthyosis-Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. AU - March, Oliver P.. AU - Lettner, Thomas. AU - Klausegger, Alfred. AU - Ablinger, Michael. AU - Kocher, Thomas. AU - Hainzl, Stefan. AU - Peking, Patricia. AU - Lackner, Nina. AU - Rajan, Neil. AU - Hofbauer, Josefina Piñón. AU - Guttmann-Gruber, Christina. AU - Bygum, Anette. AU - Koller, Ulrich. AU - Reichelt, Julia. PY - 2019/8. Y1 - 2019/8. N2 - Epidermolytic ichthyosis is a skin fragility disorder caused by dominant-negative mutations in KRT1 or KRT10. No definitive restorative therapies exist that target these genetic faults. Gene editing can be used to efficiently introduce frameshift mutations to inactivate mutant genes. This can be applied to counter the effect of dominantly inherited diseases such as epidermolytic ichthyosis. In this study, we used transcription activator-like effector nuclease technology, to disrupt disease-causing ...
TY - JOUR. T1 - Involucrin expression in keratinization disorders of the skin - a preliminary study. AU - Kanitakis, J.. AU - Zambruno, G.. AU - Viac, J.. AU - Thivolet, J.. PY - 1987. Y1 - 1987. N2 - We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Dariers disease (49%), Flegels disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichthyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that ...
PAB691Ra01, K10; CK10; KPP; Cytokeratin 10; Epidermolytic Hyperkeratosis; Keratosis Palmaris Et Plantaris; Keratin, type I cytoskeletal 10 | Products for research use only!
For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Dariers disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage ...
K1C10_HUMAN] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. ...
The nose or the cap of the dog is covered with a special kind of epidermis, which is thicker than elsewhere and does not contain any hair follicles. The nose mirror should be smooth and soft, slightly moist and with the appearance of a cobblestone path.. Hyperkeratosis. Sometimes the cornering of the nose level goes crazy: this is called hyperkeratosis. A thick, irregular edge of the horn will appear on the nose, which is drier than normal. Cracks and fissures can occur. If a blood vessel gets involved in such a tear, bleeding can occur that is sometimes difficult to stop.. How does a dog get a dry nose?. Hyperkeratosis of the nose can occur as part of skin disease, such as leishmaniasis or pemphigus. Sometimes it is also just a matter of aptitude, especially with the Labrador, this often happens.. What can you do about it?. If your dog has a dry, irregular nose surface, ask your veterinarian if he or she will find out if there is a cause for this. If there is no cause, treat the nose so that it ...
Hyperkeratosis of the nipple and areola, naevoid hyperkeratosis, hyperkeratosis areolae mammae naeviformis. Authoritative facts about the skin from DermNet New Zealand.
Hereditary footpad hyperkeratosis (HFH) represents a palmoplantar hyperkeratosis, which is inherited as a monogenic autosomal recessive trait in several dog breeds, such as e.g. Kromfohrländer and Irish Terriers. We performed genome-wide association studies (GWAS) in both breeds. In Kromfohrländer w …
Hyperkeratosis is characterized by localized thickening of the dermis and is caused by many things. Some common causes are excessive friction to the skin, constant pressure, harmful radiation, and infection. It occurs as a result of accumulation of excess keratin on certain parts of the skin. Hyperkeratosis is quite co
Hyperkeratosis: Hyperkeratosis, in cattle, a disease characterized by inflammation and thickening of the horny covering of the epidermis, the outermost layer of the skin. Other symptoms
Depending on your specific pattern of skin symptoms, your doctor will ask whether you have a family history of skin problems, and whether you have a personal history of allergies, frequent sun exposure, use of dentures or orthodontic dental appliances, unconscious chewing on your cheek or tongue or use of smokeless tobacco. Sometimes, your doctor can diagnose the cause of your hyperkeratosis by reviewing your history and symptoms and by examining your skin. This often is the case with corns, calluses, warts and chronic eczema. If you have chronic eczema that could be allergy-related, the doctor may suggest that you have allergy testing. In some cases, a biopsy may be taken to confirm the diagnosis. In a biopsy, a small piece of tissue is removed to be examined in a laboratory. If your doctor suspects that you have actinic keratoses, you may need to have a skin biopsy to confirm the diagnosis and rule out skin cancer. If your child develops hyperkeratosis in many areas of his or her body, your ...
Depending on your specific pattern of skin symptoms, your doctor will ask whether you have a family history of skin problems, and whether you have a personal history of allergies, frequent sun exposure, use of dentures or orthodontic dental appliances, unconscious chewing on your cheek or tongue or use of smokeless tobacco. Sometimes, your doctor can diagnose the cause of your hyperkeratosis by reviewing your history and symptoms and by examining your skin. This often is the case with corns, calluses, warts and chronic eczema. If you have chronic eczema that could be allergy-related, the doctor may suggest that you have allergy testing. In some cases, a biopsy may be taken to confirm the diagnosis. In a biopsy, a small piece of tissue is removed to be examined in a laboratory. If your doctor suspects that you have actinic keratoses, you may need to have a skin biopsy to confirm the diagnosis and rule out skin cancer. If your child develops hyperkeratosis in many areas of his or her body, your ...
Follicular hyperkeratosis is a skin condition in which hair follicles contain an excessive amount of keratin. This can lead to...
The case is presented of a 29-year-old female who, at the age of 13 years, developed bilateral verrucous thickening of her areolae. Despite the condition causing her significant psychosocial morbidity, a specialist referral was initially denied on the grounds that no treatment was apparently available. The condition progressively deteriorated over the subsequent 14 years. She was eventually referred for a dermatology opinion, and the diagnosis of nevoid hyperkeratosis was made. Topical therapy with keratolytics was unsuccessful, and she was referred for a plastic surgery review. Bilateral shave excision of the lesion was performed under general anesthesia, with a satisfactory outcome and no evidence of recurrence at 10 months.
Inimese 1. kromosoom ehk kromosoom 1 on inimese suurim kromosoom. Nagu kõiki teisi autosoome ehk mittesugukromosoome, on inimesel ka 1. kromosoomi kaks eksemplari. Inimese 1. kromosoom sisaldab umbes 249 miljonit aluspaari[1] ehk ligikaudu 8% kogu inimese DNA-st[2]. 2006. aastal jõuti lõpule selle kromosoomi sekveneerimisega - see oli sel ajal ühtlasi viimane veel sekveneerimata kromosoom, mille järjestuse määramiseks oli 150-l USA ja Suurbritannia teadlasel kulunud 10 aastat.[3] Juuni 2013 seisuga arvati, et selles kromosoomis on 4429 geeni, mille seas on ka 2056 valke-kodeerivat ja 1184 pseudogeeni[1]. Üksiku nukleotiidi polümorfisme ehk SNP-sid on aga ligikaudu 740 000[viide?]. Selles kromosoomis paiknevate geenidega seostatakse umbes 890 haigust või haiguslikku seisundit, mille hulka kuuluvad ka kurtus, Alzheimeri tõbi, glaukoom, eesnäärme- ja rinnavähk ning porfüüria. ...
Ravintolisät ehkäisevät kemoterapian sivuvaikutuksia, osoittavat monet pätevät tutkimukset. Ne puoltavat ravintolisien käyttöä syövän tukihoitona.
วิดิโอสำหรับการศึกษา Epidermolytic Ichthyosis-- Created using PowToon -- Free sign up at http://www.powtoon.com/youtube/ -- Create animated videos and ...
Metastaasiks ehk siirdeks ehk teiseseks haiguskoldeks (ladina metastasis) on mitmetel loomadel esineda võiv metastaatiline haiguslik seisund. Metastaasidele on iseloomulik pahaloomuliste kasvajarakkude, mikroobide levik algkoldest, peamiselt vereringe ja lümfisõlmede ning lümfisüsteemi vahendusel, organismi teistesse elunditesse. Peamiselt peetakse metastaaside puhul silmas siiski pahaloomulise kasvaja algkoldest väljaspool paikneva teisese koldega seonduvat. Kõik pahaloomulised kasvajad võivad metastaseeruda. Kui kasvaja rakk ja/või rakud erinevate tegurite kaasabil metastaseeruvad ja teises elundis paljunevad ning moodustavad seal veresoonkonnavälise kasvava massi, siis nimetatakse uut kasvajakollet rakkude sarnasuse tõttu teiseseks kasvajakoldeks. Metastaaside tavalised paikmed on luud, peaaju, diafragma, süda, maks, kops, lümfisõlmed, keskseinand, ajukelmed, kõhukelme, pleura, retroperitoneum, seljaaju.[1]. Üksikute kasvajarakkude levikut ehk mikrometastaase pole võimalik ...
Epiteelkude ehk epiteel (ingl k "epithelial tissue", kr k thēlē "nisa") on loomorganismi välispinda kattev ja sisepinda vooderdav või näärmeid moodustav kude. [1][2][3][4][5] Epiteelkoed ehk epiteelid katavad nahka, limaskesti, teiste kudede vabu pindasid ja koosnevad ainult rakkudest, (rakuvaheaine praktiliselt puudub ning pole veresooni).[5] Epiteelkoed on üks neljast loomakudede põhitüübist.[viide?] Epiteelid: ripseepiteel, näärmepiteel, transitoorne ehk üleminekuepiteel (kuseteedes esinev epiteel, mille kuju muutub) jpt. [5] Epiteelkude jagatakse funktsiooni alusel:[3][1][4] ...
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Jällegi viitan doktoritele Phinney ja Volek, kes on kirjutanud oma 30-aastase teadustöö tulemusel ka raamatu, kuidas kasutada süsivesikuvaest toitumist sporditegemise juures: "The Art and Science of Low Carbohydrate Performance". Nad ütlevad selles raamatus, et eelkõige sobib LCHF just kestvusspordialadele, kuna keha suudab glükogeenina talletada vaid umbes 2000 kcal energiat ning kui see saab pika trenni käigus otsa, siis tuleb midagi juurde süüa. Kui aga inimene on rasvakütusel ehk LCHF-toitumisega kohanenud, siis on inimesele valla tema oma keha rasvavarud ning keha ei sõltu enam oma piiratud glükogeenivarudest, mis tähendab, et energiat jätkub väga-väga pikaks pingutuseks. Ka kõige saledamatel inimestel on oma keha rasvavarudena kasutada ca 60 000 kcal ehk siis palju pikemalt saab sportida, ilma et "sein" ette tuleks. Seda teadmist on viimasel ajal päris paljud sportlased edukalt ära kasutama hakanud. Keda teema huvitab, neil soovitan üles otsida film "Cereal Killers 2: ...
X-screen on esimene X-seeria nutitelefon, mis sisaldab tippklassi funktsioone taskukohase hinnaga, pakkudes sellega konkurentsi teistele keskklassi telefonidele. X-screen on varustatud alati sisselülitatud teise ekraaniga, mis asetseb peamise 4,93-tollise HD In-cell puuteekraani kohal ning muudab lihtsaks mitme tegevusega korraga tegelemise. 1,76-tollise ekraani abil saavad kasutajad lihtsa ligipääsu rohkem kasutatavatele rakendustele, vastata kõnedele või kuulata muusikat ilma teist tegevust katkestamata. Teiselt ekraanilt saab ka alati vaadata kellaaega, kuupäeva, akuseisu ja teisi teateid ilma põhiekraani sisse lülitamata. Lisaks on X-screen nutitelefon stiilse välimusega, kristallselge klaasfiibrist korpuse ja puhaste joontega ...
காப்பீட்டின் பயன் ! - ez;gh;fNs ! tho;f;if vd;gJ xU tl;lk;. ehk; tho;tjw;fhf NghLfpd;Nwhk; gy jpl;lk;. ,d;W Nghy; tajhd fhyj;jpy; vd;Wk; ePq;fs; kfpo;r;rpahf tho - jhq;... ...
Hüpoteeklaen Smsraha.ee-st: intressimäär alates 14% aastas, tagatisvara tasuta hindamine, paindlikud tagasimakse kokkulepped. Taotle nüüd!
காப்பீட்டின் பயன் ! - ez;gh;fNs ! tho;f;if vd;gJ xU tl;lk;. ehk; tho;tjw;fhf NghLfpd;Nwhk; gy jpl;lk;. ,d;W Nghy; tajhd fhyj;jpy; vd;Wk; ePq;fs; kfpo;r;rpahf tho - jhq;... ...
B1-vitamiin aitab glükoosi energiaks muundada ning toetab närvirakkude funktsioneerimist. Puuduse peamiseks sümptomiks on väsimus. Lisaks toetab südant ja veresoonkonda ning seedetrakti tegevust.. B2-vitamiin annab uriinile erekollase värvuse. B2 on vajalik nägemisele, küünte, naha ja limaskestade terviseks. Samuti juuste normaalseks kasvuks. Ka punaseid vereliblesid ja rauaainevahetust reguleeriva vitamiini funktsioon on just B2-l.. B6-vitamiini puudus takistab kehas õnnehormoonina tuntud serontoniini tootmist, võtmeroll hormoonide tasakaalu ja immuunfunktsiooni säilitamisel.. H-vitamiin ehk biotiin (B7) on tähtis koensüüm, mis osaleb rasva ainevahetuses. Vajalik rasvhapete ja glükoosi energiaks muutmiseks, aminohapete ja valkude sünteesis ja vitamiinide B1 ja C omandamiseks. Organism vajab biotiini rakkude kasvamise tagamiseks. Sellel on oluline roll naha, juuste ja küünte tervise toetamises.. B6, B12 ja foolhape B9 toetavad kehas toimuvat olulist protsessi metüülimist, ...
25.augusti õhtul korraldame (17.00-19.00) loengu hüdrolaatide kasutamisest "Loeng lillevetest ehk hüdrolaatidest". Tutvustame hüdrolaatide toimeid, saamist ja praktilist kasutamist, lisaks tutvustame konkreetseid müügiks pakutavaid hüdrolaate. Tegutseme Sternumis aroomterapeutidena ning koolitame tulevasti aroomterapeute ning see on tinginud vajaduse ise oma töövahendid valmistada.. Ebajasmiini hüdrolaadi on valmistanud Sternumi aroomterapeudid oma aedades kasvanud taimedest. Taimede kasvatamisel ja hüdrolaadi valmistamisel ei ole üheski etapis kasutatud lisandeid.. 100% looduspuhas hüdrolaat välispidiseks kasutamiseks nahahoolduses ja lõhnastamisel ...
Looking for congenital ichthyosiform erythroderma? Find out information about congenital ichthyosiform erythroderma. the name for any of a group of diseases of humans manifested chiefly by an inflammatory reaction of the entire skin, including redness, edema, scaling, and... Explanation of congenital ichthyosiform erythroderma
Outpatient clinic for Genodermatoses or rare diseases (for Bullous congenital ichthyosiform erythroderma, Erythrokeratodermia variabilis, Harlequin type ichthyosis congenita, KID syndrome, pachyonychia congenita type 2, Mutilating Vohwinkel palmo-plantar keratoderma with deafness, Mutilating Vohwinkel palmo-plantar keratoderma without deafness, Lamellar ichthyosis/Non-bullous congenital ichthyosiform erythroderma and Sjogren-Larsson syndrome ). Genetic Skin Disease ...
Relief is when you and the right researcher find each other Finding the right clinical trial for Congenital Ichthyosiform Erythroderma can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
Looking for online definition of orthokeratotic hyperkeratosis in the Medical Dictionary? orthokeratotic hyperkeratosis explanation free. What is orthokeratotic hyperkeratosis? Meaning of orthokeratotic hyperkeratosis medical term. What does orthokeratotic hyperkeratosis mean?
A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases ...
Cancer Therapy Advisor provides dermatologists with the latest dermatology conditions, procedures and guides for different surgical and non surgical conditions. Visit often for updates and new information.
Latest information about hyperkeratosis parakeratosis Find article, review, images and graphics related with hyperkeratosis parakeratosis here.
Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skins outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever, cough, and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly ...
Hyperkeratosis, focal parakeratosis, irregular acanthosis, exocytosis, spongiosis, extravasated erythrocytes and perivascular mononuclear cell infiltration in d
List of causes of Dark areas on the cheek and Hyperkeratosis of the nails, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional. ...
Unenäod on une ajal magaja teadvuses tahtmatult esinevad nägemused, tundmused, mõtted ja emotsioonid.[1] Unenägude funktsioonid ei ole veel üheselt selged, kuigi eksisteerib mitmesuguseid teaduslikke, filosoofilisi ja religioosseid teooriaid. Unenägude teaduslikku uurimist kutsutakse oneiroloogiaks.[2]. Arvatakse, et kõige intensiivsemad unenäod esinevad kiirete silmaliigutuste (inglise keeles rapid eye movement) une staadiumis ehk REM-une ajal. Unenägude esinemise kohta on teada antud ka teistest unestaadiumidest ärgates, kuigi harvem. Mitte-REM unenäod on tavaliselt hägusemad, rahulikumad või halvemini meelde jäävad.[3] Siiski esineb väga intensiivseid unenägusid ka teistes unestaadiumides, samas pole ka mitte kõik REM-une aegsed äratused andnud kinnitust äsjasest unenäo nägemisest.[4]. Inimene näeb öö jooksul vähemalt 5 korda und, millest ta suudab mäletada 3-5 unenägu.[5] Unenäod võivad kesta paarist sekundist kuni paarikümne minutini.[3] Mida pikemalt inimene ...
With a loan from the BCIE, the improvement and renovation of 195 kilometers of roads in different areas of the country will be financed.
The term ichthyosis is derived from the Greek word ichthys, which means fish. Ichthyosis is not one disease but a group of disorders in which there is excess accumulation of epidermal cells resulting in the appearance of scales. Severity ranges from mild, asymptomatic to life threatening. There are a large number of types of ichthyosis; most are extremely rare. This condition tends to be worse in the dry, cold winter months and generally improve in the warmer, more humid months of summer. The most common type of ichthyosis is ichthyosis vulgaris which accounts for almost 95% of cases. Apart from ichthyosis vulgaris all other forms of ichthyosis are very rare. Ichthyosis vulgaris affects about 1:250 individuals. Ichthyosis occurs worldwide and affects people of all races. In addition to this there are many more types but only 3 others will be addressed here. They are lamellar, x-linked, and epidermolytic hyperkeratosis forms of ichthyosis. These conditions are inherited and are based on ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
A group of men between the 3rd and 6th decades, inclusive, of life, and of women between 1st and 5th decades, inclusive, with psoriasis, was identified. Cutaneous eruption caused by the use of drugs was more frequent between the 2nd and 5th decades in both sexes (Table 8).. Comments. In the literature, there are few notes analyzing erythroderma under its multiple aspects (Abrahams et al1, Adam2, Gatti et al6, Gentele et al7, Hasan & Jansen9, Montgomery12, Nicolis & Helwig14, Nigam et al15 and Rabello et al).16. Initially, the group of patients with erythroderma and the group of patients with other dermatosis were compared, in an attempt to find a sampling bias that might have resulted in a higher number of masculine patients in the group with erythroderma.. As no difference by sex was found when the population without erythroderma was studied (Table 1 and 3), it was concluded that the predominance of masculines in the group with erythroderma was not due to any sampling bias. This result is in ...
Staphylococcus aureus is a dangerous human pathogen which antibiotic resistance is steadily increasing and no efficient vaccine is as yet available. This serious threat drives extensive studies on staphylococcal physiology and pathogenicity pathways, especially virulence factors. Serine protease like proteins (Spl) encoded by an operon containing up to six genes are a good example of poorly characterized secreted proteins likely involved in virulence. Here we describe an efficient heterologous expression system for SplA and detailed biochemical and structural characterization of the recombinant SplA protease. The enzyme shares a significant sequence homology to V8 protease and epidermolytic toxins which are well documented staphylococcal virulence factors. SplA has a very narrow substrate specificity apparently imposed by the precise recognition of three amino acid residues positioned N-terminal to the hydrolyzed peptide bond. To explain determinants of this extended specificity we resolve the ...
Erythroderma - një emër gjenerik i lezione të ndryshme të lëkurës, të rënda skuqje përbashkët përgjithësuar e lëkurës me një krupnoplastynchatыm karakteristike e rënuar. Erythroderma më shpesh në...
Background: Ainhum, or spontaneous dactylitis, involves the formation of a gradual constriction in the digital-plantar fold of the fifth toe that leads, after several years, to autoamputation of the digit. This condition is classically distinguished from "true" ainhum, of unknown aetiology and affecting only subjects of African origin, from "pseudo-ainhum", resulting from different causes such as inflammatory constriction or constriction by a foreign body, and finally from ainhumoid palmoplantar keratoderma, which is of genetic origin and occurs for instance in Vohwinkel syndrome. Herein, we report three cases of ainhum in women of sub-Saharan African origin; in addition, all three subjects were also presenting various forms of hyperkeratosis of the hands and feet known to primarily affect subjects of African origin. Read More ...