Background-Increasing evidence indicates that elevated plasma homocysteine levels are associated with an increased risk of atherosclerosis and endothelial dysfunction, although little specific information on the mechanisms responsible for the atherogenic effects of homocysteine or on the in vivo contribution made by hyperhomocysteinemia to atherosclerosis is currently available. Because homocysteine is known to exert a direct inhibitory effect on endothelial cell growth in vitro, we hypothesized that this effect contributes to the progression of atherosclerotic lesions initiated by endothelial damage caused by mechanical injury.. Methods and Results-We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the common carotid artery was assessed. Moderate hyperhomocysteinemia (plasma homocysteine levels 3- to 4-fold higher than control) significantly exacerbated neointima formation. Oral administration of folate, which had a homocysteine-lowering ...
The purpose of this study is to investigate whether S-adenosylmethionine (SAMe), a natural substance available as a nutritional supplement, can influence blood levels of homocysteine (Hcy). More specifically, we will determine if chronic oral SAMe administration effects homocysteine metabolism in patients with vascular disease who have mild to moderate hyperhomocysteinemia through the following specific aims:. Specific Aim 1 - To determine the effect of oral SAMe (1200 mg/day) on plasma total homocysteine levels in subjects with mild to moderate hyperhomocysteinemia.. Specific Aim 2 - To determine the effect of oral SAMe (1200 mg/day) with and without supplementation of folate, vitamin B12 and B6, on plasma homocysteine levels in patients with mild to moderate hyperhomocysteinemia.. Specific Aim 3 - To determine the effect of oral SAMe (1200 mg/day) on plasma levels pf asymmetric dimethylarginine (ADMA) in subjects with mild to moderate hyperhomocysteinemia. ...
The purpose of this study is to investigate whether S-adenosylmethionine (SAMe), a natural substance available as a nutritional supplement, can influence blood levels of homocysteine (Hcy). More specifically, we will determine if chronic oral SAMe administration effects homocysteine metabolism in patients with vascular disease who have mild to moderate hyperhomocysteinemia through the following specific aims:. Specific Aim 1 - To determine the effect of oral SAMe (1200 mg/day) on plasma total homocysteine levels in subjects with mild to moderate hyperhomocysteinemia.. Specific Aim 2 - To determine the effect of oral SAMe (1200 mg/day) with and without supplementation of folate, vitamin B12 and B6, on plasma homocysteine levels in patients with mild to moderate hyperhomocysteinemia.. Specific Aim 3 - To determine the effect of oral SAMe (1200 mg/day) on plasma levels pf asymmetric dimethylarginine (ADMA) in subjects with mild to moderate hyperhomocysteinemia. ...
PubMedID: 23859838 | Folic acid attenuates hyperhomocysteinemia-induced glomerular damage in rats. | Microvascular research | 9/1/2013
A key event in Alzheimers disease (AD) pathogenesis is the formation of insoluble peptides -amyloid aggregates and this process is favoured by a condition of hyperhomocysteinemia. To date, there is growing evidence that implicates glycosaminoglycans (GAGs) in the pathophysiology of amyloidosis but no data are available on the characterization of brain GAGs involved in the enhancing -amyloid fibrillogenesis in relationship to their structure and physico-chemical properties. Furthermore, few studies have been performed on the relationship between hyperhomocysteinemia and extracellular matrix (ECM) modifications. The aim of this study was to evaluate the amount and chemical structure of GAGs in rat striatal areas where -amyioid fibrillogenesis was induced, and in conditions of hyperhomocysteinemia. The intrastriatal injection of -amyloid produced a significant decrease (-40.8%) in the hyaluronic acid (HA) percentage and an increase (+14.5%) in the dermatan sulfate (DS) with a total ...
Homocysteine (Hcy) is a thiol amino acid formed upon methionine de - methylation. A number of studies have revealed an association between hyperhomocysteinemia (HHcy), in which plasma Hcy levels exceed 15 µM, and diabetic atherosclerosis [1]. Despite these associations, the mechanisms underlying HHcy - associated diabetic atherosclerosis have not been clearly defined. This study assessed the effect of HHcy on diabetic atherosclerosis and its underlying mechanisms. We established a mouse model with a combination of three metabolic disorders, including HHcy (to mimic human HHcy), hyperglycemic (to mimic type 1 diabetes) and dyslipidemia (to exacerbate ApoE-/- mouses susceptibility to atherosclerosis). In this mouse model, severe HHcy was developed due to mouse Cbs deficiency (mean plasma Hcy 182 µM) in a noval HHcy mouse model (Tg-hCBS Cbs ApoE-/-) generated by our collaborator [2]. Hyperglycemia was developed by 50 mg/kg streptozotocin (STZ) consecutive injection for 5 days (mean blood glucose ...
Hyperhomocysteinemia is not uncommon in diabetic patients and it can aggravate cardiovascular diseases. The mechanism of this increased hyperhomocysteinemia prevalence is vague but it is suggested that, insulin plays a role in the regulation of plasma homocysteine and, insulin resistance causes hyperhomocysteinemia (18). Besides, the mechanisms that cause peripheral and/or autonomic neuropathy are complex and are not yet fully understood. Hypothetically, homocysteine can also contribute to the neuropathy development through neurovascular disruption or through direct toxic effect (8). In some studies in this field, it has been shown that there could be a link between hyperhomocysteinemia and autonomic or peripheral neuropathy (8,24). According to recent data, hyperhomocysteinemia can be a significant risk factor for cardiovascular diseases in the diabetic population (18,25). The relationship between hyperhomocysteinemia and cardiovascular diseases in patients with type 2 diabetics is 1.6 times ...
The major findings of this study are that Apoe-deficient mice exhibit accelerated arterial thrombosis and endothelial dysfunction when fed high fat and/or hyperhomocysteinemic diets. The high fat or hyperhomocysteinemic diets did not affect platelet activation responses. These findings suggest that the mechanism of accelerated thrombosis is unlikely to be attributable to effects of hypercholesterolemia or hyperhomocysteinemia on platelet activation, but instead may be related to diminished production of endothelium-derived nitric oxide or other prothrombotic factors.. As expected,17 the HF diet had a profound influence on plasma total cholesterol (Table) and atherosclerotic lesion area (Figure 1). We also found that Apoe−/− mice fed the HF diet exhibited enhanced susceptibility to carotid artery thrombosis, particularly at 12 weeks of age (Figure 3). A previous report by Eitzman et al demonstrated that short-term (5 days) feeding of a high fat diet to Apoe−/− mice resulted in accelerated ...
TY - JOUR. T1 - Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. AU - Moustapha, Ali. AU - Naso, Arabi. AU - Nahlawi, Maher. AU - Gupta, Anjan. AU - Arheart, Kristopher. AU - Jacobsen, Donald W.. AU - Robinson, Killian. AU - Dennis, Vincent W.. PY - 1998/3/31. Y1 - 1998/3/31. N2 - Background - Retrospective and case-control studies show that hyperhomocysteinemia is an independent risk factor for atherosclerosis in patients with end-stage renal disease. We studied prospectively the association between total homocysteine and cardiovascular outcomes. Methods and Results - In all, 167 patients (93 men, 74 women; mean age, 56.3±14.7 years) were followed for a mean duration of 17.4 ± 6.4 months. Cardiovascular events and causes of mortality were related to total homocysteine values and other cardiovascular risk factors. Cox regression analysis was used to identify the independent predictors for cardiovascular events and mortality. ...
Rationale: A number of epidemiological studies have suggested an association of hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies exist. In addition, we lack direct evidence supporting a causal role.. Objective: We determined the association and contribution of HHcy to AAA formation.. Methods and Results: We first performed a meta-analysis of studies involving 1489 subjects and found a strong association of HHcy and AAA (odds ratio, 7.39). Next, we used angiotensin II-infused male apolipoprotein E-deficient mice and tested whether HHcy contributes to AAA pathogenesis. Homocysteine (Hcy) supplement (1.8 g/L) in drinking water resulted in mild HHcy. Intriguingly, HHcy greatly increased the incidence of angiotensin II-induced AAA and aortic dissection in apolipoprotein E-deficient mice (vehicle versus Hcy: 50% versus 100%; ...
BACKGROUND AND OBJECTIVES: Measurement of homocysteinemia, a risk factor for venous and arterial thrombosis, is carried out in patients fasting for 12 hours and after an oral methionine load (PML). The procedure is time-consuming and several of the patients suffer from nausea and malaise. We wondered whether methionine loading could sometimes be avoided by considering fasting homocysteinemia (tHcy) levels. DESIGN AND METHODS: We evaluated whether fasting tHcy levels were useful to predict PML and deltaPML tHcy with acceptable sensitivity and specificity in 381 patients with venous and arterial thrombosis through the generation of receiver operating characteristic curves. RESULTS: Both PML and deltaPML tHcy correlated with fasting tHcy values. The cut-off of fasting tHcy value yielding a 100% sensitivity in predicting normal PML and deltaPML tHcy was 6.5 and 5.0 micromol/L in females, and 7.1 and 7.2 micromol/L in males. Fasting tHcy values yielding a 95% specificity in predicting a positive PML ...
Between July 1996 and January 1998, we studied 10 men and 12 women (mean age ± SD, 65.3 ± 11.5 years) in whom an ophthalmologist had diagnosed venous occlusion in the eye. Blood was drawn for measurement of serum total cholesterol, glucose, creatinine, folic acid, pyridoxine, and cyanocobalamin levels. The presence of coagulation abnormalities (factor V Leiden, protein S, protein C, lupus anticoagulant, and anticardiolipin antibodies) was studied. All patients underwent a methionine-loading test. The normal range for plasma total homocysteine level was less than 15 µmol/L for fasting and less than 45 µmol/L 6 hours after methionine loading ...
Background: Hyperhomocysteinemia (HHcy) is an independent risk factor for various cardiovascular diseases including hypertension, coronary artery disease and atherosclerosis. Previous studies have reported the anti-atherogenic properties of paraoxynase1 (PON1) through its homocysteine thiolactonase activity. Studies from our lab have shown abnormal matrix remodeling due to elevated MMP-9 expression, decreased vascular connexins (37 & 40) and endothelial dysfunction during HHcy. In the current study we examine the role of homocysteine and its effect on vascular remodeling during atherosclerosis in PON1 knockout mice. We hypothesize that PON1 knockout mice develop HHcy that induces MMP-9 expression and causes decreased Akt/ eNOS expression leading to vascular remodeling in atherosclerosis.. Methods: PON1 knockout mice were fed on atherogenic diet for 15 weeks as atherosclerosis disease model and compared with C57BL/6J (wild type) controls. Blood pressure was measured by tail cuff method and ...
Purpose: We hypothesize that endogenous, mild Hhcy alters retinal neurovasculature. Hhcy is implicated in diabetic retinopathy, glaucoma, CRVO & AMD, but its role is unclear. At ARVO 2014, we reported a fulminant retinal neurovasculopathy in mice deficient in Mthfr; a key enzyme in homocysteine-methionine metabolism. Further studies, revealed the Crb1 (rd8) mutation in Mthfr+/- mice, confounding our interpretation of HHcy effects on retina. To test our hypothesis, it was critical to evaluate HHcy effects due to Mthfr mutation independent of the rd8 mutation.. Methods: Mthfr+/- mice were backcrossed with C57BL6/J mice for several generations to eliminate the rd8 mutation (confirmed by genotyping).Wildtype (WT) mice (n=18) & Mthfr+/- mice (n=16) were subjected to comprehensive retinal evaluation using ERG, fundoscopy, fluorescein angiography (FA), SD-OCT, morphometric & immunohistochemical (IHC) analyses of isolectin-B4 & GFAP at 8, 12, 16, 24 wks. Two way ANOVA was used to determine whether there ...
We investigated the possible protective effect of poly (ADP-ribose) polymerase (PARP) inhibition in preventing endothelial dysfunction induced by hyperhomocysteinemia (Hhcy). Sprague-Dawley rats were
Elevated circulating total homocysteine (tHcy) concentrations (hyperhomocysteinemia) have been regarded as an independent risk factor for cardiovascular disease (CVD). However, several large clinical trials to correct hyperhomocysteinemia using B-vitamin supplements (particularly folic acid) have largely failed to reduce the risk of CVD. There is no doubt that a large segment of patients with CVD have hyperhomocysteinemia; therefore, it is reasonable to postulate that circulating tHcy concentrations are in part a surrogate marker for another, yet-to-be-identified risk factor(s) for CVD. We found that iron catalyzes the formation of Hcy from methionine, S-adenosylhomocysteine and cystathionine. Based on these findings, we propose that an elevated amount of non-protein-bound iron (free Fe) increases circulating tHcy. Free Fe catalyzes the formation of oxygen free radicals, and oxidized low-density lipoprotein is a well-established risk factor for vascular damage. In this review, we discuss our findings
Maternal perinatal nutrition may program offspring metabolic features. Epigenetic regulation is one of the candidate mechanisms that may be affected by maternal dietary methyl donors intake as potential controllers of plasma homocysteine levels. Thirty-two Wistar pregnant rats were randomly assigned into four dietary groups during lactation: control, control supplemented with methyl donors, high-fat-sucrose and high-fat-sucrose supplemented with methyl donors. Physiological outcomes in the offspring were measured, including hepatic mRNA expression and global DNA methylation after weaning. The newborns whose mothers were fed the obesogenic diet were heavier longer and with a higher adiposity and intrahepatic fat content. Interestingly, increased levels of plasma homocysteine induced by the maternal high-fat-sucrose dietary intake were prevented in both sexes by maternal methyl donors supplementation. Total hepatic DNA methylation decreased in females due to maternal methyl donors administration, while
A diet rich in methionine, an amino acid typically found in red meats, fish, beans, eggs, garlic, lentils, onions, yogurt and seeds, can possibly increase the risk of developing Alzheimers disease, according to a study by Temple researchers.. The researchers published their findings, titled "Diet-induced hyperhomocysteinemia increases Amyloid-à ² formation and deposition in a mouse model of Alzheimers disease," in the journal Current Alzheimer Research.. "When methionine reaches too high a level, our body tries to protect itself by transforming it into a particular amino acid called homocysteine," said lead researcher Domenico Praticà ², an associate professor of pharmacology in the School of Medicine. "The data from previous studies show "" even in humans "" when the level of homocysteine in the blood is high, there is a higher risk of developing dementia. We hypothesized that high levels of homocysteine in an animal model of Alzheimers would accelerate the disease.". Using a seven-month ...
In this prospective cohort of patients with documented CAD, plasma levels of homocysteine were related to future cardiovascular events. However, this relationship was predominantly present in patients with low erythrocyte intracellular GPx-1 activity and hence reduced antioxidative defense. These patients revealed a three-fold increase of risk if their homocysteine level was above the median value. In patients with high GPx-1 activity, the effect associated with elevated homocysteine appeared twice lower, even though the difference was not significant due to a small sample size, suggesting that these patients are relatively protected against oxidative adverse effects induced by hyperhomocysteinemia. These results suggest that simultaneous assessment of both biomarkers provides additional information for cardiovascular risk stratification, and that interpretation of the homocysteine levels without knowledge of the GPx-1 activity might be misleading.. In this vein, serum creatinine was also a ...
https://doi.org/10.18632/oncotarget.7384 Ahmed S. Ibrahim, Suchreet Mander, Khaled A. Hussein, Nehal M. Elsherbiny, Sylvia B. Smith, Mohamed Al-Shabrawey, Amany Tawfik
Vitamin B6 is often used to treat vitamin B6 deficiencies and hyperhomocysteinemia. This eMedTV page covers other vitamin B6 uses and explains what to discuss with your doctor before using this vitamin. Vitmin b6 is a common misspelling of vitamin B6.
Cardiovascular disease is any of a number of specific diseases that affect the heart itself and/or the blood vessel system, especially the veins and arteries leading to and from the heart. Research on disease dimorphism suggests that women who suffer with cardiovascular disease usually suffer from forms that affect the blood vessels while men usually suffer from forms that affect the heart muscle itself. Known or associated causes of cardiovascular disease include diabetes mellitus, hypertension, hyperhomocysteinemia and hypercholesterolemia. Types of cardiovascular disease include: ...
Homocysteine levels must be maintained using effective prescription drugs or nutrients. Dr Ben compares the most common homocysteine-lowering products.
The homocysteine test measures the homocysteine blood level. Get a homocysteine lab test near you at a reasonable cost - Accesa Labs
The homocysteine test measures the homocysteine blood level. Get a homocysteine lab test near you at a reasonable cost - Accesa Labs
Homocysteine, an amino acid in the blood, is associated with an increased risk of heart attack and stroke. Some experts predict homocysteine levels will prove...
This test measures levels of homocysteine in your blood. At high levels, it can damage the lining of arteries and encourage blood clotting.
Homocysteine Causes, Symptoms, Treatment - What are the possible symptoms and signs of elevated homocysteine levels? - eMedicineHealth: FONT SIZE AAA «Previous 1 2 3 4 5 ...Next» (Page 3 of 7)Glossary Homocysteine (cont.) View Heart Disease (Coronary Artery Disease) Slideshow Pictures A Visual Guide to Heart Disease Medical Illustrations of the Heart Image Collection Take the Heart Disease Quiz! FACEBOOK TWITTER EMAIL PRINT ARTICLE IN THIS ARTICLE What is homocysteine? Why are homocysteine levels measured? What are the possible symptoms and signs of elevated homocysteine levels? What are high homocysteine levels? What causes elevated homocysteine levels? Can elevated homocysteine levels be hereditary? How can homocysteine levels be lowered? Can lowering homocysteine levels prevent the risk of heart disease, heart attacks, and strokes? Who should have their homocysteine levels tested? Homocysteine Topic Guide What are the possible symptoms and signs of elevated homocysteine levels? Elevated ...
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A risk factor may show disease causation; if it suggests a plausible intervention, then it is all the more interesting. It is even better if that intervention is preventive. Robust risk factors for Alzheimer disease are now well established: increased age, the Down syndrome, poor education, and apolipoprotein E status. These risks are not easily altered. Biological risk factors that can be altered are especially attractive. Some, such as estrogen use and middle-life vascular risk-factor control, have accumulating evidence and suggest obvious, if awkward, interventions. The homocysteine story includes a plausible mechanism for causing Alzheimer disease, and the suggested intervention (dietary folate supplementation) is cheap, easy, and available to all. Folate prevents neural tube defects, a finding that has already led to dietary supplementation with folate in the United States. The study by Seshadri and colleagues is hypothesis generating and prospectively studies 1092 participants from the ...
This is the first prospective, population-based study of the role of high homocysteine levels as a risk factor for coronary heart disease and cerebrovascular disease in the elderly. The subjects mean age at baseline was 71.5 years (range, 64 to 84 years), which is substantially higher than the mean ages in previous prospective studies (46 to 60 years).4 5 6 7 8 9 Suggested cutoff values for high homocysteine levels have ranged from 11.4 to 15.8 μmol/L.2 4 5 6 7 11 16 In our study, 33% of the subjects had levels of ≥17 μmol/L. Thus, our study confirms that high homocysteine levels are extremely common among the free-living elderly.11 We found that a high serum homocysteine level was strongly associated with the baseline prevalence of myocardial infarction and stroke. During 10-year follow-up, it was associated with a modest, borderline significant increase in the risk of dying of coronary heart disease and, among normotensive subjects, with a large increase in the risk of fatal ...
Elevated homocysteine levels are influenced by a number of genetic, dietary and environmental factors.. There are many nutrients which are essential for healthy methylation function, some of these include Vitamin B6, Vitamin B12 and Folic Acid.. A lack of dietary intake of any of the above nutrients will impact methylation function and consequently homocysteine levels.. One study from 2003 concluded that B-vitamin requirements necessary to maintain normal plasma homocysteine concentrations are higher in L-dopa-treated patients than in those not on L-dopa therapy. B-Vitamin supplements may be warranted for PD patients on L-dopa therapy. [9]. Leafy greens are an excellent dietary source of folate and individuals with gene mutations such as MTHFR should consume at least 1 cup daily in order to obtain enough folate.. Sardines are an excellent source of Vitamin B12 and contain many other beneficial nutrients for individuals with Parkinsons Disease such as longchain anti-inflammatory Omega-3 fatty ...
Weve recently uncovered the mthfr mutation in my family. My daughter is homozygous c677t. Two weeks ago her homocysteine level was 17 and yesterday we received results of a test that said she was 8.8? I read the article above, she did not eat anything before both tests but she did have a coffee before test resulting in level of 17 is the coffee enough to cause such a variance? Shes been referred to a cardiologist based on symptoms and homocysteine level of 17. Should I disregard results and start over this is all overwhelming. Shes had health issues for 12 years and shes only 24. Shes been diagnosed with Polycystic ovary syndrome, subclinical hypothyroidism , chest wall syndrome. She gets strep throat 2 to 3 times a year shes had mono three times. She went to Peru for two weeks and came home so sick at the age of 17 that it took months to get back on her feet. Weve been trying to find the root issue for a long long time. She constantly has pain in chest, her joints give her issues ...
In 1992, 2 rather distinct forms of hyper-homocysteinemia were hypothesized: fasting and post-methionine loading (1). Animal experiments (2), human observations (3), and recent population-based data (4) support this hypothesis. The European Concerted Action Project (COMAC) found that approximately 30% of persons with hyper-homocysteinemia had isolated post-methionine-loading hyperhomocysteinemia, with normal fasting Hcy levels providing further confirmation of this hypothesis. More important, the COMAC data suggest that isolated post-methionine-loading hyperhomocysteinemia is not a biochemical curiosity but an independent risk factor for cardiovascular disease. The COMAC data are important for testing the hypothesis that lowering Hcy levels will reduce cardiovascular disease. If all patients at risk for mild to moderate hyper-homocysteinemia are to be identified, methionine loading is indicated. A valid 2-hour methionine-loading protocol is now available (5). The COMAC project also found that ...
Recent evidence demonstrates that hyperhomocyst(e)inaemia is a novel risk factor for cardiovascular diseases. In patients with chronic hyperhomocyst(e)inaemia, endothelial function is impaired. However, whether hyperhomocyst(e)inaemia per se is a cause or an epiphenomenon of endothelial dysfunction remains unknown. In this study, we examined the effects of methionine-induced acute hyperhomocyst(e)inaemia on human endothelial function. In healthy volunteers we administered methionine (0.1 ;g/kg body weight, per os), a substrate of homocyst(e)ine, with or without folic acid (20 ;mg, per os) and examined flow-mediated vasodilatation of the brachial artery by high-resolution ultrasonography as a non-invasive measure of endothelial function. We also measured plasma levels of homocyst(e)ine before and 3, 8 and 24 ;h after methionine loading. Methionine administration increased plasma levels of homocyst(e)ine by four times the basal level at 8 ;h (P, 0.0001, ANOVA). The plasma levels returned to ...
Question - Have high homocysteine level. Feeling tired. Which amount of folic acid is required?. Ask a Doctor about uses, dosages and side-effects of Testosterone, Ask a General & Family Physician
Slightly or even moderately increased levels of plasma homocysteine, as seen in patients with heterozygous cystathione deficiency, do not seem to indicate an increased risk of coronary artery disease (CAD). The homozygous form of this condition, associated with greater than 100-fold levels of plasma homocysteine, often indicates severe peripheral vascular disease, but patients have an incidence of CAD equal to that in an otherwise healthy population. Many observational studies, however, have found a significant association between elevated homocysteine levels and CAD. However, persons with elevated homocysteine levels may have less healthy lifestyles, which is itself a risk factor for CAD. Cleophas and associates performed a meta-analysis of case-control and cohort studies examining the relationship between homocysteine level and CAD risk.. Thirty-three studies were uncovered in a search of the literature (22 case-control and 11 cohort studies), involving a total of more than 16,000 patients. ...
SafetyAlerts) - People with elevated levels of homocysteine in the blood had nearly double the risk of developing Alzheimers disease (AD), according to a new report from scientists at Boston University. The findings, in a group of people participating in the long-running Framingham Study, are the first to tie homocysteine levels measured several years before with later diagnosis of AD and other dementias. The report, which appears in the February 14, 2002, issue of The New England Journal of Medicine, provides some of the most powerful evidence yet of an association between high plasma homocysteine and later, significant memory loss. The relationship between AD and the amino acid homocysteine is of particular interest because blood levels of homocysteine can be reduced, for example, by increasing intake of folic acid (or folate) and vitamins B6 and B12. The therapeutic use of these compounds is being explored as scientists try to understand better homocysteines role in AD or other types of ...
Coronary artery disease (CAD) is the major cause of death in both sexes in the western world. In men with chest pain the diagnostic methods are more useful than in women. An exercise test is considered less reliable in women, mostly due to a high percentage offalse positive tests. Furthermore, 20-40% of women with typical angina have normal vessels at coronary angiography. The mechanisms behind the chest pain in these patients are unknown, but could be due to disturbances in endothelial, thrombogenetic and/or fibrinolytic function.. In a prospective multicentre trial we examined 200 postmenopausal women with unstable CAD and 101 healthy controls. At coronary angiography 15% had normal vessels, 14% had non-significant atherosclerosis and 71% had at least one significant stenosis.. The diagnostic information from basic clinical parameters, ECG and an early exercise test were evaluated. The prevalence of coronary atherosclerosis was high, 85%, and the early exercise test was just as valuable as in ...
Hyperhomocysteinemia is implicated in retinal neurovascular illnesses including arterial occlusive disease, venous occlusive pseudoexfoliation and disease glaucoma. research to elucidate systems of HHcy-linked retinal disease. A medically relevant experimental program may be the mouse deficient or inadequate the gene encoding CBS enabling studies of the consequences of gentle to serious endogenous elevation of Hcy [30]. In prior studies, we analyzed implications on retina function and framework using either mice, that have a much milder HHcy with ~4C7 collapse upsurge in plasma Hcy (and a 2-collapse upsurge in retinal Hcy) and a standard lifespan. Our function shows that both mice possess retinal neuronal disruption and participation from the retinal vasculature [31C36]. To understand systems for HHcy-induced retinal neuronal loss of life we previously looked into the function of excitotoxicity and oxidative tension using perforated patch clamp evaluation and fluorescent recognition of ...
A moderate increase in plasma total homocysteine (t-hcy) is considered to be an independent risk factor for cardiovascular disease (CVD) in general population. One of the mechanisms by which hyperhomocysteinemia contributes to cardiovascular risk has
The serum concentration of the amino acid homocysteine is positively associated with the risk of ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke. 1 2 There is uncertainty over whether these associations are causal. 3 4 Resolving the question of causality is important because serum homocysteine can be lowered by the B vitamin folic acid, 5 6 raising the prospect of a simple and safe means of prevention.. Three rare autosomal recessive disorders (the homocystinurias), in which homozygotes lack one of the three principal enzymes in homocysteine metabolism, cause extremely high serum homocysteine levels (,100μmol/l) and a high risk of premature cardiovascular disease (affecting half of homozygotes by the age of 307). The biochemical change that is common to all three disorders is a high serum homocysteine concentration (no other substance is consistently high or low), 8 9 indicating that high homocysteine levels cause cardiovascular disease.. Whether moderate ...
Disease and Homocysteine Concentration. Dogs in the heart disease, neoplastic disease, kidney disease, and skin disease groups had significantly higher plasma Hcy concentrations than control dogs. However,multivariate logistic regression analyses adjusted for age, sex, and spay/neuter status revealed that Hcy concentration was only associated with skin disease when these other variables were included in the model. The odds ratio per 1 μmol/l increase in Hcy was 1.077, 95% confidence interval (CI) 1.001-1.158, p,0.05. In the control group (n=187), the mean plasma Hcy concentration was 13.5 ± 0.4 μmol/l (first quartile-median-third quartile 9.6-12.8-16.0, and min-max 4.3-50.1 μmol/l). In the skin disease group (n=16), the mean plasma Hcy concentration was 20.3 ± 2.3 μmol/l (first quartile-median-third quartile 13.8-19.3-23.3, and min-max 9.7-49.8 μmol/l). The skin disease group included five Shih Tzus and 11 other dogs of nine different breeds. However, our finding that Hcy ...
Background: In the past 37 years, increased efforts have been directed toward a better understanding of the importance of Hcy in disease and it has now become clear that hyperhomocysteinemia is a major independent risk factor for CVD. Extensive research on the influence of vitamin supplementation leading to reductions in Hcy levels and improvements in cardiovascular function has been done. The importance of exercise in the lowering of cardiovascular risk factors, as well as its favourable influence on cardiovascular function has also been indicated in several studies, however, the limited number of studies investigating the effect of exercise on Hcy concentrations revealed contradicting results. Furthermore, a relationship between Hcy concentration and cardiovascular function with the intervention of an exercise training and a vitamin supplementation programme respectively has also not been investigated. Objective: The objective of this study was to examine the effect of a 12-week exercise ...
To evaluate whether increased plasma homocysteine concentrations (hyperhomocysteinemia) are associated with thrombosis of arteriovenous (AV) grafts, we determined plasma homocysteine, plasma and erythrocyte folate, plasma vitamin B12, and vitamin B6 (pyridoxal-5-phosphate [PLP]) in 48 patients (45 black patients and three white patients) with end-stage renal disease who received hemodialysis. 5,10-Methylenetetrahydrofolate reductase (MTHFR) genotypes were also analyzed. The patients were divided into two groups, including a thrombosis-prone group with frequent graft loss (n = 24) and a control group with prolonged graft survival who were matched by age and duration of dialysis (n = 24). Hyperhomocysteinemia (>15 μmol/L) was found in 42 patients. There were no significant differences in all values, including the concentrations of homocysteine and vitamins between the two groups. Based on plasma folate and PLP concentrations, over 70% of patients appeared to have Inadequate folate and/or vitamin ...
article{74c6c5e2-5f8f-4bce-afbd-04daa1c85807, abstract = {Background/Objectives: In previous studies we observed a high incidence of elevated plasma homocysteine (tHcy) concentrations in psychogeriatric patients. Plasma tHcy is increased in folate deficiency. Folates are sensitive to oxidative stress. Oxidative stress, caused by inflammatory processes, could represent an endogenous reason for folate deficiency, even when the dietary intake of the vitamin is within the recommended range. It has been suggested that oxidative stress rather than insufficient folate intake causes hyperhomocysteinemia in different forms of psychogeriatric diseases. In the present study we investigated the association between plasma tHcy and C-reactive protein (CRP), a sensitive marker for inflammation, in psychogeriatric patients. Methods: Plasma tHcy, its main determinants, and CRP were measured in plasma and serum of 132 psychogeriatric patients (53 males and 79 females, mean age 75 12 years). Results. In the ...
Elevated homocysteine levels have been linked from everything from cancer to diabetes to autoimmune disorders to stroke (however, please note that these results are far from unanimous, there are a number of studies showing the contrary for each of the diseases listed. Furthermore, there is still some debate as to whether the high levels of homocysteine are a causal factor for these disorders or just another side effect or symptom of these disorders. Nevertheless, the near-ubiquitous presence of high homocysteine levels in so many diseases across the board should at least suggest that homocysteine-lowering efforts are of great potential benefit, at least in this bloggers opinion).. With regards to ADHD, the actual role of homocysteine is, admittedly, much more murky. While the mechanisms and overall physiology of an ADHD brain vs. a Parkinsons brain show acute differences (In ADHD, chemical imbalances between the "inside" and "outside" regions of a neuron exist, which can be chemically modified ...
Elevated homocysteine levels have been linked from everything from cancer to diabetes to autoimmune disorders to stroke (however, please note that these results are far from unanimous, there are a number of studies showing the contrary for each of the diseases listed. Furthermore, there is still some debate as to whether the high levels of homocysteine are a causal factor for these disorders or just another side effect or symptom of these disorders. Nevertheless, the near-ubiquitous presence of high homocysteine levels in so many diseases across the board should at least suggest that homocysteine-lowering efforts are of great potential benefit, at least in this bloggers opinion).. With regards to ADHD, the actual role of homocysteine is, admittedly, much more murky. While the mechanisms and overall physiology of an ADHD brain vs. a Parkinsons brain show acute differences (In ADHD, chemical imbalances between the "inside" and "outside" regions of a neuron exist, which can be chemically modified ...
Plasma homocysteine levels in patients with deep venous thrombosis.: Increased risk of arterial and venous thromboembolic disease is well documented in the homo
Altered retinal vasculature in cbs −/− mice. Histological assessment of retinal cryosections stained with hematoxylin and eosin (A, B), showing retinal hemorrhage (white arrow) and grossly dilated blood vessels in the cbs −/− retina (B) compared to the normal retina of wild-type (cbs +/+) mouse (A). Retinal flat mounts (C-F) stained with isolectin-B4 (endothelial cell marker) labeling the retinal vasculature. Retina of cbs −/− mouse shows central capillary dropout (D) compared to healthy central vasculature of cbs +/+ mouse (C). Neovascular tufts (arrows) were observed in retinas of cbs −/− mice (F), which were not observed in the cbs +/+ mouse retina (E). Experiments were performed in five mice. Scale bar: 40 μm (B), 200 μm (D, F). Morphometric assessment of the central capillary-free areas showed significant increase in cbs −/− retinas compared to wild-type (cbs +/+) retinas ([G], *P , 0.05, n = 4 mice per group). Vasculature of the 3-week-old cbs +/− mice was mildly ...