The present study demonstrates that pathogenic events in fetal arteries associated with maternal hypercholesterolemia are capable of enhancing the susceptibility to atherosclerosis later in life, and that cholesterol-lowering interventions or antioxidant treatment of hypercholesterolemic mothers during pregnancy have long-term beneficial effects in their offspring.. As previously demonstrated in the same rabbit model,13 diet-induced maternal hypercholesterolemia during pregnancy markedly increased fatty streak formation during fetal development, whereas maternal treatment with vitamin E or cholestyramine significantly reduced lesion sizes in their offspring, compared with untreated mothers. In the present study, a higher dose of vitamin E (1000 IU) was used than in the preceding one (100 IU). This yielded a greater reduction of lesion sizes and intimal content in lipid peroxidation products at birth. After weaning and five months on the mildly hypercholesterolemic diet, lesion sizes in aortic ...
The current study investigated the effects of hyperglycemia, hypertension, and hypercholesterolemia on the severity of sequelae related to traumatic brain injury. Existing data of 209 participants was utilized from an urban hospital, which included neuropsychological evaluations following traumatic brain injury. Specific areas examined included measures of executive functioning, both immediate and delayed memory, and learning. Each participant was placed into a group based on the number of documented diagnoses (hyperglycemia, hypercholesterolemia, and hypertension). The control group consisted of patients that did not carry a record of these health risks. Each of these groups was further stratified according to age. An interaction between the variables of health risk factors and neuropsychological assessment results was predicted specified by decreasing standard scores with the increase in number of health risk factors. Furthermore, age was hypothesized to be a main effect, with the prediction of a
Inclusion criteria :. - Participants with primary hypercholesterolemia treated with atorvastatin at stable dose of 5-20 mg for at least 6 weeks prior to screening and likely to have LDL-C ≥100 mg/dL (≥2.59 mmol/L) at the screening visit.. OR. - Participants with primary hypercholesterolemia who were receiving a lipid-lowering treatment other than atorvastatin, or who were not at stable dose of atorvastatin 5-20 mg for at least 6 weeks prior to screening if they were likely to have LDL-C ≥100 mg/dL (≥2.59 mmol/L) after a 6-week run-in treatment period on atorvastatin therapy.. Exclusion criteria:. ...
Low levels of high-density lipoproteins (HDLs) may constitute an independent risk factor that may be as important as elevated low-density lipoproteins (LDLs) in coronary artery disease (CAD). Concentrations and distributions of lipids, apolipoprotein (apo) B, and apoA-I in the plasma and lipoprotein subfractions of two groups of swine, one with familial hypercholesterolemia (FHC) and the other with diet-induced hypercholesterolemia (DHC), were examined. Normolipidemic (NL) animals served as controls. All pigs carried the Lpb5 apoB mutation, which is known to influence the formation of atherosclerotic lesions. Mean concentrations of serum total cholesterol in NL, DHC, and FHC were 80.0 +/- 9.3, 774.3 +/- 54.5, and 316.5 +/- 36.1 mg/dL, respectively; HDL cholesterol (HDL-C), 33.5 +/- 1.9, 137.0 +/- 9.9, and 22.3 +/- 2.2 mg/dL; triglycerides, 33.0 +/- 16.3, 40.3 +/- 11.7, and 56.8 +/- 7.2 mg/dL; apoB, 35.7 +/- 3.1, 142.0 +/- 4.8, and 169.3 +/- 13.9 mg/dL; and apoA-I, 62.4 +/- 9.3, 170.9 +/- 6.9, ...
Hypercholesterolemia: High blood cholesterol. This can be sporadic with no family history) or familial. Familial hypercholesterolemia is the most common inherited type of hyperlipidemia (high lipid levels in blood). It predisposes to premature arteriosclerosis including coronary artery disease with heart attacks at an unusually young age. About half of men and a third of women suffer a heart attack by age 60. Persons with familial hypercholesterolemia can reduce their risk by adhering to a very low cholesterol diet under a doctors supervision, and may also need to take medications that reduce their cholesterol level. Familial hypercholesterolemia is recognizable in childhood. Children and other relatives at risk for familial hypercholesterolemia can be screened (checked) for the condition. Familial hypercholesterolemia is due to a geneticdefect in the receptor (the dock on the surface of cells) for LDL (low density lipoprotein). ...
This study compared the efficacy and pharmacodynamics of atorvastatin versus rosuvastatin in hypercholesterolaemic patients with or without the
CYP7A1 encodes the rate limiting enzyme for the conversion of cholesterol to bile acids. Several studies have demonstrated that elevated expression of CYP7A1 confers protection from hypercholesterolemia. CYP7A1 expression is regulated by two nuclear receptors, farnesoid X receptor (FXR) and small heterodimer (SHP). Here we demonstrate that although FXR−/ − and SHP−/ − mice have similarly elevated levels of CYP7A1, FXR−/ − mice have elevated serum cholesterol and triglyceride levels and serum markers of hepatic inflammation whereas the SHP−/ − mice do not. This suggestion of a beneficial lipid effect of the loss of SHP was confirmed in a cholesterol/cholic acid diet model, in which SHP−/ − mice were strongly protected form diet-induced hypercholesterolemia and hepatic inflammation. To examine the effects of the loss of SHP in a model relevant to human dyslipidemia, we generated LDLR−/ −SHP−/ − mice. The LDLR−/ −SHP−/ − mice were highly resistant to Western ...
METHODS AND RESULTS Normal or hypercholesterolemic rabbits received intravenous L-arginine (10 mg/kg/min) or vehicle for 70 minutes. Subsequently, animals were killed, thoracic aortas were harvested, and vascular rings were studied in vitro. Rings were contracted by norepinephrine and relaxed by acetylcholine chloride or sodium nitroprusside. Vasorelaxation was quantified by determining the maximal response (expressed as percent relaxation of the contraction) and the ED50 (dose of drug inducing 50% relaxation; expressed as -log M). In vessels from hypercholesterolemic animals receiving vehicle, there was a fivefold rightward shift in sensitivity to acetylcholine compared with normal animals (p = 0.05, n = 5 in each group). In vessels from hypercholesterolemic animals, L-arginine augmented the maximal response to acetylcholine (83 +/- 16% versus 60 +/- 15%, p = 0.04 versus vehicle) and increased the sensitivity to acetylcholine (ED50 value: 6.7 +/- 0.2 versus 6.2 +/- 0.2, p less than 0.05 versus ...
Hypercholesterolemia is common in older adults and less treated, but little is known about correlates of untreated hypercholesterolemia. Using a standard interview method we examined a random sample of 7,572 participants aged 60 years in a community-based household survey across 7 provinces of China during 2007-2012, and documented 328 cases of hypercholesterolemia from self-reported doctor diagnosis. Compared to participants with normal cholesterol, older adults with hypercholesterolemia had higher socioeconomic position and larger body mass index. In patients with hypercholesterolemia, 209 were not treated using lipid-lowering medications (63.7%, 95% confidence interval (CI) 58.5%- 68.9%). Untreated hypercholesterolemia was significantly associated with female sex (adjusted odds ratio 2.13, 95%CI 1.17-3.89), current smoking (3.48, 1.44-8.44), heavy alcohol drinking (3.13,1.11-8.84), chronic bronchitis (2.37,1.14-4.90) and high level of meat consumptions (2.85,1.22-6.65). Although having ...
KEGG : 36 Autosomal recessive hypercholesterolemia (ARH) is a rare disorder characterized by elevated low-density lipoprotein (LDL) serum levels, xanthomatosis, and premature coronary artery disease. Several dyslipidemias have been identified which lead to severe primary hypercholesterolemia. Among them, ARH is characterized by clinical symptoms and plasma cholesterol levels intermediate between those found in heterozygous and homozygous familial hypercholesterolemia (FH) [DS:H00155] individuals. ARH patients develop symptomatic coronary artery disease later in life and their xanthomas tend to be large and bulky. In 2001, ARH was found to be caused by mutations in the LDL receptor adaptor protein 1 (LDLRAP1). In ARH, the internalization of the ligand-receptor complex cannot occur and all the LDL receptors accumulate on the cell membrane. In general, ARH patients show a better response to lipid-lowering therapy than the FH patients, and they rarely require LDL apheresis ...
TY - JOUR. T1 - Altered myocardial microvascular 3D architecture in experimental hypercholesterolemia. AU - Rodriguez-Porcel, Martin. AU - Lerman, Amir. AU - Ritman, Erik L.. AU - Wilson, Stephanie H.. AU - Best, Patricia J.M.. AU - Lerman, Lilach O.. PY - 2000/10/24. Y1 - 2000/10/24. N2 - Background - Experimental hypercholesterolemia (HC) impairs intramyocardial microvascular function. However, whether this is associated with alterations in microvascular architecture remained unknown. Using a novel 3D micro-CT scanner, we tested the hypothesis that HC is associated with an alteration in the microvascular architecture. Methods and Results - Pigs were euthanized after 12 weeks of either normal (n=6) or 2% HC (n=6) diet. The hearts were excised and the coronary arteries injected with a radiopaque contrast material. Myocardial samples were scanned with micro-CT, and 3D images were reconstructed with 21-μm cubic voxels. The myocardium was tomographically subdivided into subepicardium and ...
We investigated whether primary hypercholesterolaemia per se affects glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice (LDLR(-/-)). Glucose plasma levels were increased and insulin decreased in LDLR(-/-) compared to the wild-type mice. LDLR(-/-) mice presented impaired glucose tolerance, but normal whole body insulin sensitivity. The dose-response curve of glucose-stimulated insulin secretion was shifted to the right in LDLR(-/-) islets. Significant reductions in insulin secretion in response to L-leucine or 2-ketoisocaproic acid were also observed in LDLR(-/-). Islet morphometric parameters, total insulin and DNA content were similar in both groups. Glucose uptake and oxidation were reduced in LDLR(-/-) islets. Removal of cholesterol from LDLR(-/-) islets corrected glucos-estimulated insulin secretion. These results indicate that enhanced membrane cholesterol content due to hypercholesterolaemia leads to a lower insulin secretion and glucose intolerance ...
P8 We have studied the effect of valsartan treatment (3 and 10 mg/kg/day) on plasma fibrinolytic balance in normo- and hypercholesterolemic rabbits. Animals were fed a normal chow or an experimental diet containing 1% cholesterol for 10 weeks. Systolic blood pressure, as well as plasma cholesterol, dimer D, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) were measured. Plasma cholesterol concentrations were higher in rabbits fed the experimental diet compared with control ones. None of the doses of valsartan were able to affect either plasma cholesterol or blood pressure levels in any group.As compared with control animals hypercholesterolemic rabbits presented lower dimer D (0.37±0.07 mg/ml vs 0.96±0.13, p,0.05) and tPA levels (0.27±0.003 ng/ml vs 0.31±0.007, p,0.05) but higher PAI-1 levels (11.1±0.9 ng/ml vs 8.84±0.04, p,0.05). In cholesterol-fed rabbits, valsartan treatment (3 or 10 mg/kg/day) significantly increased both dimer D (0.73±0.1 mg/ml and, ...
During homeostasis hematopoietic stem and progenitor stem cells (HSPCs) give rise to lymphoid and myeloid cells as well as platelets and erythrocytes. However, during chronic inflammatory conditions hematopoiesis is often skewed towards the myeloid lineage, thereby potentially aggravating the ongoing inflammation. Here we investigated the effects of hypercholesterolemia on HSPCs during atherogenesis.. Hypercholesterolemia increased HSPCs, defined as Lin-Sca1+cKit-, in the bone marrow (BM) of LDLr-/- mice by 253.1%. The number of granulocyte-monocyte progenitors, BM granulocytes and BM monocytes was increased by 18.1%, 34.8% and 13.2%, respectively. In accordance, the myeloid colony forming potential of hypercholesterolemic BM was increased by 25.8%. Peripheral blood monocytes and granulocytes were increased by 203.0% and 161.1%, respectively.. Competitive bone marrow transplantations (cBMT) in which we compared the effects of normo- vs. hypercholesterolemia primed HSPCs confirmed that the ...
Evidence-based recommendations on evolocumab (Repatha) for treating primary hypercholesterolaemia (high cholesterol) and mixed dyslipidaemia
Evidence-based recommendations on alirocumab (Praluent) for treating primary hypercholesterolaemia (high cholesterol) and mixed dyslipidaemia
Hypo and hypercholesterolemic rats strains were selected (Lyon) and compared to a normocholesterolemic one issued from the same race (Sprague-Dawley). The arterial tissue of these three strains at three ages (10-19-25 months) and their reactivity to an hyperlipidic diet (2 and 6 month duration) were studied using histological and histochemical technics. There were neither histological nor histochemical differences between the three strains whatever the ages. Therefore, at the present stage of selection, the genetic differences have not changed the arterial metabolism or its evolution during ageing. However the arterial reactivity of hypo and hypercholesterolemic strains towards an hyperlipidic diet was different: indeed both strains developed hypercholesterolemia, liver steatosis and diffuse intimal lipoidosis, but on the other hand the hypercholesterolemic rat alone demonstrated arterial cell proliferation. These data suggest that a same genetic trait can give rise to both a spontaneous
... What Are High Blood Cholesterol and Triglycerides? Learn about high blood cholesterol and why it is damaging to your health.
Looking for a low fat, high fiber ingredient to add to your cholesterol-lowering diet? Look no further. Lentils are a good legume to have on-hand.
Extracorporeal methods of therapy are used only to severe forms of pathology. Special innovative devices change the composition of blood and its properties (outside the human body).. Natural remedies for hypercholesterolemia should be used only with the permission of the physician and together with the methods of traditional medicine. The most effective natural remedies: the root of the Dioscorean of Nippon; berries of a dogrose; immortelle sandy; leaves watch three-leafed; a powder of seeds of a thistle; the roots of blue cyanosis; grasses; celandine; artichoke prickly.. Possible Complications:. Hypercholesterolemia may cause atherosclerotic changes in the vessels.. Prevention:. Prevention of hypercholesterolemia can be divided into primary and secondary. Primary prevention is a method that should be used to prevent an increase in amounts of cholesterol in the blood. Such events include:. ...
Behavioral and psychosocial factors have been shown to influence cardiovascular disease. While interventions targeting these risk factors demonstrate clinical improvement, mechanisms underlying these effects remain to be determined. Research has also defined a relationship between psychosocial stress and immune function, and revealed stress related increases in lymphatic sympathetic nerve density. Considering that inflammation characterizes the various stages of heart disease, the current study assessed whether social stress could influence vascular sympathetic innervation in the presence or absence of hypercholesterolemia. We found dense sympathetic innervation extending into the vascular media and intima throughout the aortic arch and thorax in diseased as well as non-diseased animals. To our knowledge, this is the first demonstration of extensive sympathetic innervation in all layers of normal vessels. Compared to NZW animals, WHHL rabbits displayed increased sympathetic innervation and a
The role of the endothelium was examined in the response to aggregating platelets in cerebral arteries from normal and hypercholesterolemic animals. Male Yorkshire pigs were fed either a normal diet or a 2% high-cholesterol diet for 10 weeks. Endothelium-dependent responses were examined in vitro. In rings of basilar arteries from control animals aggregating platelets caused endothelium-dependent relaxations, which were significantly inhibited by apyrase, an adenosine diphosphatase and triphosphatase, but were augmented by methiothepin, a combined S1- and S2-serotonergic blocker. In quiescent rings platelets induced contractions that were inhibited by the presence of the endothelium; these contractions were significantly inhibited by methiothepin, but not by ketanserin (an S2-serotonergic blocker) or dazoxiben (a thromboxane-synthetase blocker) in the presence or absence of SQ29548 (a thromboxane-receptor blocker). Adenosine diphosphate but not serotonin caused endothelium-dependent relaxations. ...
Pedigree of an infant with severe hypercholesterolemia who presented with cutaneous xanthomas. (A) Pictures taken at presentation of cutaneous (planar) xanthoma
Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today positive results from its Phase I clinical trial of ALN-PCS, an RNAi therapeutic targeting PCSK9 for the treatment of severe hypercholesterolemia.
Persons with familial hypercholesterolemia can reduce their risk by adhering to a very low cholesterol diet under a doctor​s supervision,​ and may also need to take medications that reduce their cholesterol level. Familial hypercholesterolemia is recognizable in childhood. Children and other relatives at risk for familial hypercholesterolemia can be screened (checked) for the condition ...
TY - JOUR. T1 - Prostacyclin, thromboxane A2, and atherosclerosis in young hypercholesterolemic swine. AU - Norman, J. F.. AU - Miller, C. W.. PY - 1994/10. Y1 - 1994/10. N2 - Plasma 6-keto-prostaglandin F1α and thromboxane B2 levels were determined to evaluate their role as predictive indicators for the development and progression of coronary atherosclerosis in young hypercholesterolemic swine. 32 young swine were randomly assigned to the control or atherogenic diet group for 10, 30, 90, or 180 days. Lipid profiles were obtained at the onset and repeated throughout the study. Radioimmunoassays of plasma 6-keto-prostaglandin F1α and thromboxane B2 were recorded at 10 day intervals in the 10 and 30 day subjects and at 30 day intervals in the 90 and 180 day subjects. Sections from the proximal left anterior descending coronary artery were classified based on their histological evidence of atherosclerosis by light microscopy. Hypercholesterolemia was positively correlated with development of ...
List of drugs used to treat hypercholesterolemia, including various medications for hypercholesterolemia treatments. These medical treatments that are used to fight...
Do You Have Hypercholesterolemia? Join friendly people sharing true stories in the I Have Hypercholesterolemia group. Find support forums, advice and chat with groups who share this life experience. Hypercholesterolemia anonymous support group with i...
Cholesterol is a lipid or fat that is produced by the liver. It is crucial for body function and metabolism. However, there is a certain amount of this compound that should be present in human body. High cholesterol level can harm your health in
There are conflicting results regarding the erythrocyte membrane cholesterol and phospholipid content in patients with primary hypercholesterolemia (PHC), due to methodological problems in obtaining haemoglobin-free ghosts. At the same time, the diff
This study is aimed to collect the following Serbia-specific epidemiology data on hypercholesterolemia: patents characteristics, patients management/treatment and physicians standard practice. In addition, the aim is to determine the proportion of patients on lipid-lowering pharmacological treatment who have reached the LDL-C and HDL-C treatment goals ...
EDITORIAL COMMENTS. http://dx.doi.org/10.5546/aap.2016.eng.398. Genetic and epigenetic, the case of hypercholesterolemia. To size up how important the human genome description is, the researchers who described it illustrated the relevance of genes in the development of conditions that create a large burden on public health. The authors reported on ApoE genetic variations and their role in the development of hypercholesterolemia and cardiovascular disease. This is an important issue, which calls upon us to reflect on how knowledge has evolved in the past decades.. Morbidity and mortality from cardiovascular disease (CVD) across Europe between 1990 and 1992 was greatly dissimilar among countries. Mortality among 45-74-year-old men was 655/100 000 inhabitants per year in Scotland, whereas it was 142/100 000 inhabitants per year in France, i.e., 4.5 times higher. The mortality rate among Scottish women in the same age group was 7.5 times higher than among their French counterparts.1 Subsequent ...
Rash is found among people with High blood cholesterol, especially for people who are female, 60+ old also have High blood pressure and take medication Niaspan.
High blood cholesterol, a serious hereditary disease, is far more common than previously recognised and not treated sufficiently.
Hypercholesterolemia is most commonly, but not exclusively, defined as elevated levels of low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (HDL-C); an alternative term is dyslipidemia, which encompasses elevated triglycerides, low levels of HDL-C, and qualit...
Cho-Less-Terin takes a natural approach to cholesterol management and includes such nutraceuticals as Red Yeast extract, guggul lipids, beta-glucans, green tea extract and plant sterols. Sixteen studi (SKU: 628747118385)
The addition of LY3015014, an investigational PCSK9 inhibitor, to standard lipid-lowering therapy may be safe and effective when administered every 4 to 8 weeks to patients with hypercholesterolemia, according to mew phase 2 data. John J.P. Kastelein, MD, professor of medicine and strategic chair of genetics of cardiovascular disease, department of vascular medicine at the Academic Medical Center
Family history. In some cases, hypercholesterolemia can be present in young patients, not caused by any illness, but due to genetics. Some inherited diseases such as hyperlipidemia or hypercholesterolemia can lead to dangerous levels of blood cholesterol, very difficult to control. For this reason, cholesterol levels should be maintained consistently low through diet and / or medication. However, some genetic abnormalities may promote increased cholesterol levels, regardless of diet or lifestyle adopted by the patient - familial hypercholesterolemia is a condition with genetic transmission, which increases the level of abnormal blood cholesterol ...
Genzyme and Isis Pharmaceuticals announced results of two Phase 3 studies of patients who had high cholesterol levels while on maximally tolerated lipid-lowering therapy.
Cholesterol is a waxy substance that helps the body create vitamin D, steroid hormones, and cell membranes. It also synthesizes bile acids, which aid in digestion. But not all cholesterol is good. Chronically high levels of bad cholesterol is hypercholesterolemia.
To the Editors: Before we start a massive treatment program for hypercholesterolemia in elderly persons, as recommended in the review article by Denke and Grundy (1) and endorsed in the editorial by Kafonek and Kwiterovich (2), several notes of caution must be injected. I would emphasize that the recommendation to treat is based on extrapolation of data from younger patients and that there is currently no evidence that lowering cholesterol levels will alter the risk for heart disease in the elderly. Even the current studies have not looked at persons in their 70s and 80s. Yet these people have heard ...
This phase IIa study will investigate the efficacy and tolerability of multiple doses of RN 316 as adjunctive treatment in hypercholesterolaemic patients on
When the total levels of cholesterol (LDL + HDL) are higher than 200mg/dl, we are witnessing a case of hypercholesterolemia: the excess cholesterol tends to build up inside the arteries forming athero
Pure hypercholesterolemia is an inherited condition that might raise unhealthy cholesterol levels. The most common symptoms of...
Background Hypercholesterolemia is one of the most important factors causing cardiovascular disease (CVD). The aim of the present work was to evaluate the relationships between socio-demographic,...
ANEMIA and HYPERCHOLESTEROLEMIA related symptoms, diseases, and genetic alterations. Get the complete information with our medical search engine for p
Learn about Pure hypercholesterolemia. What are the symptoms, the causes and how to treat this condition? What can we do to cope and prevent its symptoms?
Comparison of aging and hypercholesterolemic effects on the sodium inward currents in cardiac myocytes.: To study and to compare the hypercholesterolemic and ag
TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents ...
French doctors prescribe more patented statins than their European counterparts. The countrys health service spends €1.2 billion on statins every year, double the budget of some European countries. EURACTIV France reports. Hypercholesterolemia is an illness that causes elevated levels of LDL cholesterol, known as "bad cholesterol", in the blood. Along with obesity, diabetes and arterial hypertension, it constitutes one of the major risk factors for heart disease.. Between 35% and 40% of the adult population in Germany, France and the UK suffer from hypercholesterolemia. In Spain and Italy this figure is around 10%.. ,, Read: Kidney function linked to cardiovascular health Cutting hypercholesterolemia would have the knock-on effect of reducing deaths from heart disease. The most effective treatments often involve no medication, and a patients risk of developing the condition is greatly decreased by lifestyle choices such as quitting smoking, doing more exercise, reducing alcohol consumption ...