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Egg-shell calcium (Ca) is one of the effective Ca sources for bone metabolism. In the present study, we investigated whether egg-shell Ca had similar effects compared with calcium carbonate (CaCO3) when vitamin D3 (1alpha(OH)D3) treatment was given to an osteoporotic rat model. In both 1alpha(OH)D3- …
The invention provides a new vitamin D2 compound, 1α-hydroxy-24-epi-vitamin D2 and certain hydroxy-protected derivatives thereof. The new compound exhibits a distinctive activity pattern comprising high potency in stimulating intestinal calcium transport and little or no activity in inducing bone calcium mobilization or the differentiation of undifferentiated cells in culture, thereby evincing utility in the treatment of diseases characterized by loss of bone mass.
Find out how to take Alfacalcidol (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.
Generic for One-alpha (Alfacalcidol) is a Vitamin. Buy now with us and save $55.00. InternationalDrugMart.com offers best quality medications at discount.
The effect of 1-alpha-hydroxycholecalciferol and parathyroidectomy on cardiovascular lesions in uraemia: an experimental study in the rat ...
EFFECTS OF ORAL ALFACALCIDOL ON MATURATION OF DENDRITIC CELLS IN GRAVES DISEASE PATIENTS: A DOUBLE-BLINDED RANDOMIZED CLINICAL TRIAL
Looking for 1,25-dihydroxycholecalciferol? Find out information about 1,25-dihydroxycholecalciferol. 1,25-dihydroxycholecalciferol, the form of vitamin D that is involved in intestinal absorption of Ca2+and Ca2+resorption by bone Explanation of 1,25-dihydroxycholecalciferol
Parenteral 1,25-dihydroxycholecalciferol in hepatic osteomalacia.: Despite regular long-term parenteral vitamin D2 treatment, four patients with biliary cirrhos
Disclosed is a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of pains and pyrexia, hypertension, hypotension, hyperlipemia, inflammatory diseases or diseases due to the functional accentuation of thrombocytes of a compound of 24,25-dihydroxycholecalciferol and a pharmaceutical acceptable carrier or diluent therefor.
Cholecalciferol, better known as vitamin D3, is naturally produced in the skin of animals that results from a reaction to sunlight. Excessive amounts of cholecalciferol can have adverse, and even fatal effects.
Alfacip is used to treat osteoporosis and conditions with impairments of calcium metabolism such as bone loss due to age. 0.5/mcg 0.25/mg.
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On occasion, horses will come into contact with horse feed that has been contaminated with cholicalciferol, an active ingredient in many types of rat poison. Learn the signs of this type of poisoning and the common ways to treat it.
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In the context of the global prevalence of vitamin D insufficiency, we compared two key determinants of the bioavailability of 3 vitamin D forms with significant biopotencies: cholecalciferol, 25-hydroxycholecalciferol and 1-α-hydroxycholecalciferol. To this aim, we studied their incorporation into synthetic mixed micelles and their uptake by intestinal cells in culture. Our results show that 1-α-hydroxycholecalciferol was significantly more solubilized into mixed micelles compared to the other forms (1.6-fold and 2.9-fold improvement compared to cholecalciferol and 25-hydroxycholecalciferol, respectively). In Caco-2 TC7 cells, the hydroxylated forms were taken up more efficiently than cholecalciferol (p | 0.05), and conversely to cholecalciferol, their uptake was neither SR-BI(Scavenger-Receptor class B type I)- nor NPC1L1 (NPC1 like intracellular cholesterol transporter 1)-dependent. Besides, the apical membrane sodium-bile acid transporter ASBT (Apical Sodium-dependent Bile acid Transporter) was
1,25-DHCC, 1,25-dihydroxy-22-ovavitamin D(3), 1,25-dihydroxycholecalciferol, 1,25-dihydroxy-vitamin-D (1,25(OH)(2)D), 1,25-dihydroxyvitamin D3, 1,25-diOHC, 1,25(OH) 2D3, 1-alpha (OH) D3, 19-nor-1, 1-alpha-hydroxycholecalciferol, 1-alpha-hydroxyvitamin D2, 1-hydroxyvitamin D, 22-oxacalcitriol (OCT), 24,25(OH)(2)vitamin D(3), 25 hydroxyvitamin D (25(OH)D), 25-dihydroxyvitamin D2, 25-dihydroxyvitamin D2, 19-nor-1, 25-HCC, 25-hydroxycholecalciferol, 25-hydroxyvitamin D, 25-hydroxyvitamin D3, 25-OHCC, 25-OHD3, activated 7-dehydrocholesterol, activated ergosterol, alfacalcidol, calcifediol, calcipotriene, calcipotriol, calcitriol, cholecalciferol, colecalciferol, cod liver oil, dichysterol, dihydrotachysterol, dihydrotachysterol 2, doxercalciferol, ecocalcidiol, ED-21 (vitamin D analog), ED-71 (vitamin D analog), ergocalciferol, ergocalciferolum, falecalcitrol, hexafluoro-1,25dihydroxyvitamin D3, irradiated ergosterol, maxacalcitol, MC903, Ostelin , paracalcin, paricalcitol, tacalcitol, Vi-delta ...
Secondary hyperparathyroidism has a significant impact on morbidity and mortality in advanced chronic kidney disease (CKD).Both nonselective and selective vitamin D receptor activators (VDRAs) are demonstrated in many studies for their efficacy on suppression of PTH. Most of them are quite expensive and unavailable in many countries. Calcitriol and alfacalcidol are less expensive and worldwidely distributed. There is only one short-term study which directly compares these two drugs. This study demonstrates that calcitriol is superior to alfacalcidol. However, alfacalcidol is a prohormone of calcitriol. It has to be converted by 25-hydroxylase at the liver to generate 1,25-dihydroxyvitamin D3 to act on target cells. Many pharmacokinetics studies demonstrate that alfacalcidol has lower AUC compared to calcitriol if they are administered in the same dose. Therefore, the authors hypothesize that alfacalcidol may be equivalently efficacious as calcitriol if its dose is adjusted according to the ...
M. A. Preece, J. L. H. ORiordan, D. E. M. Lawson, S. Edelstein, E. Kodicek; Studies of the Kinetics of Competitive Protein Binding Assays of Cholecalciferol and of 25-Hydroxycholecalciferol. Clin Sci 1 April 1972; 42 (4): 16P-17P. doi: https://doi.org/10.1042/cs042016Pb. Download citation file:. ...
Tacalcitol | VDR agonist | PRI 2191 | 1α,24-Dihydroxycholecalciferol | PRI2191 | CAS [57333-96-7] | Axon 2516 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
BACKGROUND We conducted the present study to investigate the therapeutic effects of a combination treatment of alfacalcidol (ALF) and risedronate (RIS) on the bone mechanical properties of bone and calcium (Ca) metabolism using an ovariectomized (OVX) rat model of osteoporosis. METHODS Female Wistar rats were OVX- or sham-operated at 40 weeks of age. Twelve weeks post-surgery, rats were randomized into seven groups: 1) sham + vehicle, 2) OVX + vehicle, 3) OVX + ALF 0.025 microg/kg/day, 4) OVX + ALF 0.05 microg, 5) OVX + RIS 0.3 mg, 6) OVX + RIS 3.0 mg, 7) OVX + ALF 0.025 microg + RIS 0.3 mg. Each drug was administered orally five times a week for 12 weeks. After treatment, we evaluated the mechanical properties of the lumbar vertebra and femoral midshaft. In the lumbar vertebra, structural and material analyses were performed using micro-computed tomography (micro-CT) and microbeam X-ray diffraction (micro-XRD), respectively. Biochemical markers in serum and urine were also determined. RESULTS (1)
For the ASCO study, researchers defined insufficiency as 25-hydroxy-vitamin D [25(OH)D] less than 30 ng/ml and deficiency as levels less than 20 ng/ml. Clinical guidelines recommend that level or even higher, with some suggesting vitamin D levels between 40 ng/ml and 60 ng/ml might be best ...
According to Natural News, there is evidence that stress, fatigue and depression are connected to low serum levels of vitamin D, in addition to known immunity, illness and disease issues. The more up-to-date integrative or holistic MDs and naturopaths recognize that 25-hydroxy-vitamin D or 25(OH)D3 test serum levels should be in the range of 50…
Cholecalciferol, also called vitamin D-3, is a fat-soluble vitamin that is necessary for the maintenance of a healthy body. Your body makes cholecalciferol when your skin is exposed to ultraviolet rays from the sun, according to MayoClinic.com.
Toan T, Ryan RC, Simon GL, Calabrese JC, Dahl LF. CRYSTAL-STRUCTURE OF 25-HYDROXY-VITAMIN D3 MONOHYDRATE - STEREOCHEMICAL ANALYSIS OF VITAMIN-D MOLECULES. Journal of the Chemical Society-Perkin Transactions 2. 1977 :393-401. ...
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
There are 30 fifteen-letter words containing A, 2C, E and F: CAPRIFOLIACEOUS CERTIFICATORIES CHOLECALCIFEROL ... RECODIFICATIONS SPEECHIFICATION SUBSPECIFICALLY. Every word on this site is valid scrabble words. See other lists, that start with or end with letters of your choice.
TY - JOUR. T1 - Effects of combined administration of alfacalcidol and risedronate on cancellous and cortical bone mass of the tibia in glucocorticoid-treated young rats. AU - Iwamoto, Jun. AU - Seki, Azusa. AU - Takeda, Tsuyoshi. AU - Yamada, Harumoto. AU - Sato, Yoshihiro. AU - Yeh, James K.. PY - 2008/1/1. Y1 - 2008/1/1. N2 - The purpose of the present study was to examine the effects of combined administration of alfacalcidol (ALF) and risedronate (RIS) on cancellous and cortical bone mass of the tibia in glucocorticoid (GC)-treated young rats. One hundred and nine female Sprague-Dawley rats, 3 months of age, were randomly divided by the stratified weight method into eleven groups according to the following treatment schedule: baseline control, a 4-week age-matched control, and a 4-week GC administration with a 4-week concomitant administration of vehicle, ALF, RIS, or ALF+RIS, and an 8-week age-matched control and 8-week GC administration with a 4-week administration of vehicle, ALF, RIS, ...
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The effects of hydroxylated derivatives of vitamin D3 and aqueous extracts of Solanum malacoxylon on the intestinal absorption of calcium, phosphate, sodium, potassium and water have been studied in unstressed vitamin D-replete pigs each of which was surgically prepared beforehand with a Thirty-Vella loop of jejunum. The addition, for six 1 h periods of perfusion, of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) or 1α-hydroxycholecalciferol at similar concentrations (3·6-3·75 pmol/ml) to the solution used to perfuse the intestinal loop caused a rapid increase in the absorption of calcium but increased the absorption of phosphate only after a delay of at least 12 h. The absorption of both calcium and phosphate reached a maximum on the day following the addition of the vitamin D derivative to the perfusate. The addition of 25-hydroxycholecalciferol (25-(OH)D3) at a concentration of 3·75 pmol/ml was without effect on absorption except for a small increase in the absorption of phosphate on the ...
The active vitamin D metabolite 1 25 D3 (1 25 has been proven to be a significant regulator of innate and adaptive immune function. gene appearance which treatment using a physiological focus of 25(OH)D3 down-regulated IFN-γ and IL-17F gene appearance ...
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Cholecalciferol is a form of vitamin D thats synthesized by the skin after exposure to sunlight. Its also added to many foods as...
RATIONALE: The use of cholecalciferol and calcium carbonate may keep colon cancer from coming back in patients with colon cancer that has been removed b
TY - JOUR. T1 - The metabolism of 1,25-dihydroxyvitamin D3.. AU - Kumar, Rajiv. PY - 1980/6. Y1 - 1980/6. UR - http://www.scopus.com/inward/record.url?scp=0019030105&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019030105&partnerID=8YFLogxK. M3 - Article. C2 - 6894425. AN - SCOPUS:0019030105. VL - 1. SP - 258. EP - 267. JO - Endocrine Reviews. JF - Endocrine Reviews. SN - 0163-769X. IS - 3. ER - ...
Sigma-Aldrich offers abstracts and full-text articles by [Steve Y Rhieu, Andrew J Annalora, Guochun Wang, Caroline C Flarakos, Rose M Gathungu, Paul Vouros, Rita Sigüeiro, Antonio Mouriño, Inge Schuster, G Tayhas R Palmore, G Satyanarayana Reddy].
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There arent words to describe that feeling when you leave your house and start riding, to realise halfway through that you dont have a jacket on, and frankly, you dont care; the sun has graced us with its presence over the last week and it has been wonderful! Most of the weekend was spent at…
TY - JOUR. T1 - Plasma 1,25(OH)2 vitamin d measured by radioimmunoassay and cytosol radioreceptor assay in normal subjects and patients with primary hyperparathyroidism and renal failure. AU - Peacock, Munro. AU - Taylor, G. A.. AU - Brown, Wendy. PY - 1980/2/14. Y1 - 1980/2/14. N2 - Antibodies to 1α,25-dihydroxy vitamin D3 25-hemisuccinate linked to albumin were produced and an immunoassay for 1,25-dihydroxy vitamin D developed. Plasma 1,25-dihydroxy vitamin D concentrations were compared using an immunoassay and cytosol radioreceptor assay. Both assays gave comparable results but the immunoassay was more reproducible, slightly more sensitive and had a lower detection limit. Using the immunoassay the plasma 1,25-dihydroxy vitamin D was 110.5 pmol/l (S.D. 29.4) in normal subjects; there was no difference between males and premenopausal females. It was negatively related to plasma phosphate. In renal failure and primary hyperparathyroidism plasma 1,25(OH)2D was positively related to radiocalcium ...
1. 1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) was given at a dose of 5-0 nmol (2-1 mug) daily by mouth for 4-12 days to three patients with hypophosphataemic (type I), vitamin D-resistant rickets. 2. 1,25-(OH)2-D3 increased intestinal absorption and urinary excretion of calcium without
1. The rapid stimulation of intestinal Ca2+transport observed in vitamin D-deficient chicks after receiving 1,25-dihydroxycholecalciferol has necessitated a re-evaluation of the correlation hitherto observed between this stimulation and the induction of calcium-binding protein synthesis. By 1h after a dose of 125ng of 1,25-dihydroxycholecalciferol, Ca2+transport is increased. This is at least 2h before calcium-binding protein can be detected immunologically and 1h before synthesis of the protein begins on polyribosomes, and thus the hormone stimulates Ca2+transport before calcium-binding-protein biosynthesis is induced. 2. The maximum increase in Ca2+transport observed after this dose of 1,25-dihydroxycholecalciferol (attained by 8h) is similar to that observed after 1.25-25μg of cholecalciferol, but the stimulation is only short-lived, in contrast with the effect observed after the vitamin. At later times after the hormone, however, when Ca2+transport has declined to its basal rate, the ...
Product Human 25 Hydroxy Vitamin D ELISA kit From B-Gene - A sandwich ELISA for quantitative measurement of Human 25 Hydroxy Vitamin D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUTION*1 vial 12. WASH SOLUTION (100 x)*1 vial 13. BALANCE SOLUTION*1 vial 14. INSTRUCTION*1
An analogue of 1,25-dihydroxyvitamin D3, 22(S)-24-homo-26,26,26,27,27,27-hexafluoro-1α,22,25-trihydroxyvitamin D3 (DD-003), showed 10-fold greater inhibiting effect than 1,25-dihydroxyvitamin D3 on the growth of HT-29 human colonic adenocarcinoma cells in culture. To examine the anticancer activity of DD-003 in vivo, a fibrin clot of HT-29 cells was prepared with fibrinogen and thrombin and implanted under the renal capsule of the severe combined immunodeficient mouse. Starting 7 days after implantation of HT-29 tumor, mice were given 3 µg/kg body weight of DD-003 or the vehicle i.p. every other day for 5 times. The HT-29 tumor grew rapidly in control mice; malignant growth was clearly observed with mitosis, massive tumor angiogenesis, and invasion into normal kidney tissue. Tumors in DD-003 treated mice were smaller with less invasion compared to the control. Administration of DD-003 inhibited growth of HT-29 tumor by 63%. Serum calcium concentrations and body weights of the treated mice were ...
This new report from VPGMarketResearch.com provides analysis of 25-Hydroxy Vitamin D2 and D3 testing, including clinical significance, current and emerging diagnostic ...
Vitamin D deficiency (hypovitaminosis D) is typically diagnosed by measuring the blood concentration of the 25-hydroxyvitamin D (Calcifediol, Calcidiol), which is a precursor to the active form of the 1,25-dihydroxy-vitamin D (Calcitriol) compound.. The blood concentration of 25-hydroxy-vitamin D reflects vitamin D produced in the skin as well as vitamin D acquired from the foods and has a relatively long circulating half-life of 15 days. It does not, however, reveal the amount of vitamin D stored in other body tissues and organs (muscles, liver, bones etc).. ...
To date, 31 cases and 7 controls are enrolled. The mean ± SD case age is 7.2 ± 1.4 years; 55% are male. The mean control age is 6.4 ± 1.3 years; 57% are male. The mean 25-hydroxy vitamin D level for cases is 21.5 ± 7 ng/mL (n=23). This mean is at the cutpoint for vitamin D insufficiency [serum 25-hydroxy vitamin D level,20 ng/mL]. Ten cases (43%) are vitamin D insufficient. The mean 25-hydroxy vitamin D level for controls is 29 ± 3.3 ng/mL (n=4) … ...