Abstract:. Ascites and hydrothorax are common complications of liver cirrhosis, however, unilateral isolated hepatic hydrothorax without associated ascites is an unusual and challenging complication of liver cirrhosis. Though rare, this condition often poses both diagnostic and therapeutic dilemma, especially in patients without other symptoms or risk factors for cirrhosis. It usually leads to prolonged hospitalization and may cause early mortality. Unilateral isolated hepatic hydrothorax may also be the only pointer to underlying cirrhosis in the absence of ascites. Liver transplantation remains the only definitive treatment for this condition.. ...
Diagnostic approaches to PD-related hydrothorax can be broadly divided into biochemical and imaging approaches.. The basis of the biochemical approach is that PD-related hydrothorax is believed to have a high pleural-fluid glucose concentration. However no validated reference range exists to aid diagnosis. Some investigators believe that only a pleural fluid glucose concentration greater than 16.5 mmol/L (300 mg/dl) would be diagnostic [9].. Chow and others [10] have hypothesized that, given dynamic movement of dialysate, an absolute glucose-concentration level cannot be used to diagnose PD-related hydrothorax. The pleural fluid-to-serum glucose concentration gradient of greater than 2.77 mmol/L (50 mg/dl) was proposed as the cut-off to diagnose the condition [10]. Subsequent studies, however, found this to be unreliable [11], and generally any pleural-fluid glucose concentration greater than serum is considered to be highly supportive of PD-related hydrothorax.. All studies assessing imaging ...
TY - JOUR. T1 - Low pleural fluid-to-serum glucose gradient indicates pleuroperitoneal communication in peritoneal dialysis patients. T2 - Presentation of two cases and a review of the literature. AU - Momenin, Nima. AU - Colletti, Patrick M.. AU - Kaptein, Elaine M.. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Background. Transudative pleural effusions due to pleuroperitoneal communication occur in 1.6-10% of patients receiving peritoneal dialysis (PD) and usually have overtly elevated glucose concentrations. Methods. We report two cases of verified pleuroperitoneal communication with minimally elevated pleural fluid glucose levels. We reviewed the literature of all PD patients with pleuroperitoneal communication that reported pleural glucose levels to assess their clinical and laboratory features and pleural fluid-to-serum glucose gradients. Results. We evaluated a total of 47 reported patients on PD with diagnosed pleuroperitoneal communication. Onset of the transudative pleural effusion after ...
Central venous catheter (CVC)-induced hydrothorax is a delayed complication after the placement of an indwelling subclavian or internal jugular central venous catheter. The catheter tips may cause long-lasting mechanical damages that lead to a slow erosion of the wall of the superior vena cava (SVC), thereby resulting in hydrothorax. The damage may stem from the catheter tips being positioned inappropriately or from the relocation of the catheter tip that was initially ideally positioned. We describe an 80-year-old woman with CVC-induced hydrothorax. She presented with spinal subdural hematoma and preoperatively underwent a multiple-lumen CVC insertion through her left subclavian vein. Her recovery course was uneventful after surgical hematoma removal and spinal cord decompression. However, thirty hours after the CVC placement, the patient began to suffer from an increasing dyspnea. The chest X-ray showed right-sided, massive pleural effusion and a widened mediastinum, requiring the removal of ...
An 89-year-old man with a history of multiple abdominal surgeries and ventriculoperitoneal (VP) shunt placement for normal pressure hydrocephalus presented for intractable abdominal bloating and scrotal swelling, for which imaging revealed massive ascites, bilateral hydrocele and small bilateral pleural effusions. Cardiac, hepatic and renal workup were insignificant. Culture and cytology of ascitic fluid were negative for infection or malignancy. Aetiology of the ascites as secondary to Cerebrospinal fluid (CSF) from the VP shunt was confirmed via ligation of the shunt. Sterile CSF ascites, hydrothorax and hydrocele are rare complications of VP shunt for hydrocephalus and are mostly presented in paediatric patients. We report the first known case of concurrent CSF ascites, hydrothorax and hydrocele in an elderly patient. We examine the difficulty of shunt replacement as a diagnostic and treatment modality in this age group and propose the use of reversible shunt ligation as a diagnostic modality. ...
BACKGROUND Refractory hepatic encephalopathy (HE) frequently develops in patients with cirrhosis and portal-systemic shunt. Recently, patients with refractory HE associated with portal-systemic shunt have been treated with interventional radiology. We describe a promising new treatment for portal-systemic shunt, ligation of the patent paraumbilical vein (PUV) after partial splenic embolization, in patients with refractory HE. PATIENTS Four patients with cirrhosis (3 women and 1 man; mean age, 56 years) and refractory HE due to a patent PUV were studied. Patency of the PUV had recurred in 1 patient after primary occlusion by interventional radiological procedures. The Child-Pugh class was B in 2 patients and C in 2. Before the present treatment, all patients had been hospitalized at least 3 times because of recurrent HE. SURGICAL PROCEDURE Partial splenic embolization was performed in all patients to decrease portal venous pressure before surgery. Surgical ligation of the patent PUV was performed
We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese version of the Support Team Assessment Schedule. The psoas muscle index (PMI) was used to define sarcopenia. A statistically significant difference was observed in the PMI between patients receiving low-dose (3.6 ± 1.2 cm2/m2) and high-dose furosemide (3.1 ± 1.2 cm2/m2) before tolvaptan treatment (P = 0.048). The PMI increased from 3.2 ± 1.1 cm2/m2 to 3.5 ± 1.3 cm2/m2 (P = 0.002) in responders, but decreased from 3.4 ± 1.2 cm2/m2 to 3.0 ± 1.0 cm2/m2 (P = 0.106) in non-responders before and after tolvaptan treatment, respectively. The long-term prognosis improved in responders compared with non-responders (mean survival time: 646 days vs. 228 days, P | 0.001). Early introduction of tolvaptan treatment is necessary to prevent the progression of sarcopenia.
Main causes of hydrothorax are cancer, cardiovascular diseases, renal diseases, acute pancreatitis, hepatic cirrhosis and thromboembolism.
Researchers from The Johns Hopkins Center for Fetal Therapy report new evidence that fetuses with severe congenital diaphragmatic hernia (CDH), a rare but life-threatening, lung-damaging condition, experience a significantly high rate of success for the fetal treatment known as FETO, if they and their mothers receive coordinated and highly experienced care in the same expert setting.. A report on the findings was published online, on Feb. 6, in the journal Obstetrics & Gynecology.. FETO - fetoscopic tracheal balloon occlusion - is a minimally invasive procedure in which a fetoscope is inserted through the abdominal wall into the uterus and then into the mouth of the fetus to place an inflatable balloon, to temporarily block the fetal trachea. The blockage allows lung fluids to build up behind the balloon, encouraging expansion of the airways and lung growth. The procedure improves the odds that fetuses with severe CDH acquire sufficient lung function after birth to lead a normal life.. The ...
Left chart: chest film shows, Mediastinal or great place left chest complicated with hydrothorax, left the 4th rib defect destruction. Figure on right: postoperative chest, left the 4th rib missing, left lung translucent less. (Text/figure s.m.Sze) recently, Xinhua hospital affiliated to Shanghai Jiao Tong University School of 1 cases suffering from chest huge on the success of mesenchymal tumor resection of sarcoma of the 5-year-old girl. The child with chest CT showed that a left thoracic giant tumor which not only takes up the entire left side pleural effusion, and involving the whole chest and left to the right of the abdomen, diaphragm was left completely into the abdominal cavity. Mass ratio of transverse diameter and pleural effusion transverse diameter of 90%. After careful study and analysis of image data, Professor of cardiothoracic surgery at the hospital Mei Ju raised median sternotomy on chest + section of abdominal incision, first open the diaphragm by squeezing expose masses of ...
Generally, excessive body liquids accumulating in coelom is called hydrops such as hydrothorax, Celiac hydrops and hydrocardia, etc. Generally speaking, edema is usually a sign of disease which often can lead to edema. But not all of edema means nephritis and edema is not the specific characteristic of kidney disease, which can be caused by other reasons such as cardiac edema, hepatic edema, nutritional edema, medical edema and idiopathic edema, etc ...
The aim of this study was to check whether echocardiography is useful in patients with thoracic anomalies undergoing an invasive therapy in utero. Material and Methods: Retrospective analysis of 42 pregnant women and their fetuses (2003 - 2012), which, due to the chest anomalies had genetic ultrasound and ECHO and then were subjected to an invasive intrauterine therapy. Results: The mean maternal age was 30.2 years, there were 18 high risk pregnancies and 24 low-risk pregnancies, the average gestational age at diagnosis was 28.2 wks (17 - 38), the average week of delivery was 35 wks (24 - 41), the average birth weight was 2700g (700 - 4050g). The average number of fetuses with chest anomalies undergoing therapy in utero in our center was 4.2 per year. The most common anomaly was hydrothorax, then CALM and DH and one case of AS. Anomalies coexisted with generalized edema, ascites and/or polyhydramnios. Most often shunts and/or decompression of pleural fluid and / or abdominal cavity were ...
End period liver disease (ESLD) noted by scores from the particular SSA Chronic Liver Condition (SSA CLD) calculation (5. 05G). We will not evaluate your own acute encephalopathy under 5. 05F if it results coming from conditions other than chronic liver disease, such since vascular events and neoplastic diseases. The necessary findings must be present on from least two evaluations a minimum of 60 days apart within just a consecutive 6-month period and despite continuing treatment as prescribed. Ascites or hydrothorax (5. 05B) indicates significant loss in liver function due to chronic liver disease. Symptoms of long-term diseases in the liver may have a new poor correlation using the seriousness of liver disease in addition to functional ability.. Helicobacter pylori management in non-steroidal potent drug therapy patients inside primary care. A extremely high rate of improper use of gastroprotection for nonsteroidal anti-inflammatory drug treatment in primary care: the cross-sectional study. ...
Pregnancy can be an anxious time as many mothers worry about the normality of their babies. Since the majority of pregnancies do not encounter any problems, the ultrasound can positively reassure the mother of normality in her baby. Ultrasound will also enable the early diagnosis of major malformations such as anencephaly (baby without a brain), which are incompatible with life. Some anomalies that are amenable to intra-uterine therapy such as isolated hydrothorax (fluid in the lung) can be identified. Other malformations may warrant post-natal attention such as gastroschisis (a defect in the abdominal wall resulting in the gut outside the abdomen) needing surgery can also be easily identified ...
Safety assessment studies in at least two animal species (rodent and nonrodent) are typically conducted before entering clinical trials with experimental therapeutics. Building safety margins based on experience, as well as a perspective on how safety findings in animal studies eventually translate into clinical outcomes, is of paramount importance. Although thiazolidinediones are effective as a class in treating NIDDM in animals and humans, the concordance (degree and specificity) between the safety profile of specific thiazolidinediones in animals and humans is generally lacking in the peer-reviewed literature. This article reports the relevance of preclinical safety assessment findings in rats and nonhuman primates to humans of a potent thiazolidinedione, darglitazone.. The major adverse event identified in darglitazone-treated rats and monkeys was the development of a life-threatening hydrothorax. The high incidence of morbidity/mortality occurred at doses ≥5 mg/kg/day (serum drug exposure ...
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The investigators have recently developed a novel aerosol-based imaging technique to detect changes in liquid absorption in the airways - a central pathophysiological process known to be important in cystic fibrosis (CF) lung disease. This technique may provide a measure of disease severity and indication of therapeutic correction in advance of currently available outcome measures. It involves the simultaneous delivery of two radiopharmaceuticals by inhalation: one an absorbable small-molecule (Indium-111 labeled diethylenetriaminepentaacetic acid; In-DTPA) and the other a non-absorbable particle (Technetium 99m labeled sulfur colloid; Tc-SC). The overarching hypothesis is that In-DTPA absorption provides a quantifiable, non-invasive measurement of airway liquid absorption that (a) is sensitive to CF genotype, (b) uniquely identifies basic disease phenotype and predicts disease severity, and (c) is modulated by therapeutic interventions ...
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Expertise, Disease and Conditions: Amniotic Band Syndrome (ABS), Congenital Diaphragmatic Hernia, EXIT Procedure, Fetal Cardiac Defects, Fetal Echocardiography, Fetal Hydrops, Fetal Hydrothorax, Fetal Surgery, Fetal Therapy, Fetal Tracheal Balloon Occlusion, Fetoscopy, Intrauterine Growth Restriction, Lower Urinary Tract Obstruction (LUTO), Maternal and Fetal Medicine, Multiple Gestations, Obstetrics, Placental Dysfunction, Prenatal Ultrasound, Spina Bifida, Twin Anemia Polycythemia Sequence, Twin Reversed Arterial Perfusion, Twin-to-Twin Transfusion Syndrome ...
Expertise, Disease and Conditions: Amniotic Band Syndrome (ABS), Congenital Diaphragmatic Hernia, Exit Procedure, Fetal Cardiac Defects, Fetal Echo, Fetal Hydrops, Fetal Hydrothorax, Fetal Surgery, Fetal Tracheal Balloon Occlusion, Fetoscopy, Gynecology and Obstetrics, Intrauterine Growth Restriction, Lower Urinary Tract Obstruction, Maternal and Fetal Medicine, Multiple Gestations, Obstetrics, Placental Dysfunction, Prenatal Ultrasound, Spina Bifida, Twin Anemia Polycythemia Sequence, Twin Reversed Arterial Perfusion, Twin-to-Twin Transfusion ...
Embolization of Large Spontaneous Portosystemic Shunts for Refractory Hepatic Encephalopathy: A Multicenter Survey on Safety and Efficacy Wim Laleman, 1 Macarena Simon-Talero, 2 Geert Maleux, 3 Mercedes
No pathological lesion, the result of disease but had its beginning in disturbance so obscure that our method for disclosing, so as to name the disease, are totally inadequate, except it be in their manifestations through so-called subjective symptoms. The stinging pains causing the criencephilique occuring in meningeal troubles, may precede for days the effusion which characterise and gives the name hydrocephalus to the case, and for which Apis is such an excellent remedy. So with hydrothorax and Bryonia. Drugs will always produce pathological lesions if carried to their possible results, and it is not sense to infer that they cannot because they have not. Again we quote We must realize that in the large majority of cases in which drugs give very good accurate results, practically all of them; (Thanks N.) but practically all of them, are capable of spontaneous recovery. Now, if homoeopathy is worth anything it meets those things which are not capable of spontaneous recovery. If the doctor had ...
The association of a benign ovarian tumor with ascites and hydrothorax that resolve after tumor resection is known as Meigs syndrome, and its importance was first emphasized by Meigs and Cass in 1937. The importance of Meigs syndrome is that the pres
Fibrothecomas ara unilateral benign stromal ovarian tumors, with a predilection for the left ovary (70%). Most often they arise in middle-aged women, and are rare in children. They may be detected incidentally for other reasons, or due to symptoms relating to torsion. A very small percentage (2%) of ovarian fibromas present with Meigs syndrome, which features a fibroma or thecoma accompanied by ascites and hydrothorax, in which removal of the tumor results in cure. ...
Antibody titres can be detected serologically by haemagglutination inhibition, ELISA, serum neutralisation and other methods. Antibodies can also be detected in foetuses. Viral antigen can be demonstrated in brain, placenta and foetuses by indirect fluorescent staining (IFAT) and avidin-biotin staining. On post-mortem of piglets from infected dams, hydrocephalus, hydrothorax, subcutaneous oedema and necrotic foci within the organs are common. The meninges and spinal cord may be congested and cerebellar hypomyelinogenesis has been described. [1] In male infected pigs, large amounts of mucoid fluid are present within the tunica vaginalis and the epididymis and tunic are fibrosed. ...
Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure that may be used to reduceportal hypertensionand its complications, especiallyvariceal bleeding. A TIPS procedure may be done by a radiologist, who places a small wire-mesh coil (stent) into a liver vein. The stent is then expanded using a small inflatable balloon (angioplasty). The stent forms a channel, or shunt, that bypasses the liver. This channel reduces pressure in the portal vein. By reducing portal hypertension, enlarged veins (varices) are less likely to rupture and bleed. And other complications of cirrhosis called ascites (fluid in the abdomen) and hepatic hydrothorax (fluid between the lungs and the chest wall) may improve or go away.. TIPS may be used to:. ...
Pleural effusion secondary to ventriculoperitoneal shunt insertion is a rare and potentially life-threatening occurrence. We describe a 14-month-old Caucasian boy who had a ventriculoperitoneal shunt inserted for progressive hydrocephalus of unknown etiology. Two and a half months post-shunt insertion, the patient presented with mild respiratory distress. A chest radiograph revealed a large right pleural effusion and a shunt series demonstrated an appropriately placed distal catheter tip. A subsequent abdominal ultrasound revealed marked ascites. Fluid drained via tube thoracostomy was sent for beta-2-transferrin electrophoresis. A positive test was highly suggestive of cerebral spinal fluid hydrothorax. Post-externalization of the ventriculoperitoneal shunt, the ascites and pleural effusion resolved. Testing for beta-2-transferrin protein in pleural fluid may serve as a useful technique for diagnosing cerebrospinal fluid hydrothorax in patients with ventriculoperitoneal shunts.
Four types of fluid can occupy the pleural space: serous fluid (hydrothorax), blood (hemothorax), lipid (chylothorax), and pus (empyema). Once the presence of a pleural effusion is established, it is important to determine whether it is a transudate or an exudate. A transudative pleural effusion indicates the presence of a systemic process, implicating organ systems other than the lung. This transudative pleural effusion is caused by medical conditions that lead to volume overload, such as renal failure, heart failure, and hypoalbuminemia (Table 127-1). In contrast, exudative pleural effusions indicate a local pleural process and necessitate a different treatment approach (Table 127-2). In 1972, Light defined the classic criteria for distinguishing between exudative and transudative pleural effusions.1 To qualify as an exudate, the pleural effusion must meet one of the following criteria: pleural fluid lactate dehydrogenase (LDH) greater than 200 IU/L, ratio of pleural fluid LDH to serum LDH ...
Empyema is pus in the pleural space. A parapneumonic effusion is a pleural effusion associated with a lung infection, usually pneumonia but infrequently a lung abscess. Bacterial pneumonia with a parapneumonic effusion is the most common precursor, seen in about 60% of empyema patients.1 Other causes of empyema are complications of chest surgery (22%), trauma (4%), esophageal perforation (4%), complications of chest tube/thoracentesis (4%), an extension from a subdiaphragmatic infection (3%), and assorted triggers (7%), including a hemothorax, chylothorax, or hydrothorax that becomes infected due to a systemic infection with hematogenous spread such as septicemia.1,2 ...
the cuffed or tunnelled line and the reservoir long line that ends in a rubber bulb or reservoir.. The possible complications of a central venous line include air in the chest (pneumothorax) due to a punctured lung, bleeding in the chest (hemothorax), fluid in the chest (hydrothorax), bleeding into or under the skin (hematoma) and infection. If the line becomes disconnected, air may enter the blood and cause problems with breathing or a stroke.. A central venous line is also called a central venous catheter. Sometimes, the venous is omitted and it is called a central line or central catheter.. ...
Complications of nasogastric tubes and orogastric tubes in anesthetized patients have been extensively documented.1 The photograph represents an nasogastric tube that coiled around an endotracheal tube during insertion in an anesthetized patient and formed a tight knot around the endotracheal tube when removal was attempted. The knot around the endotracheal tube obstructed ventilation. When removal of the nasogastric tube was attempted, there was loss of end-tidal carbon dioxide with elevated peak airway pressures noted from the ventilator. Confirmation of the endotracheal tube obstruction was made via direct laryngoscopy. The patient was extubated, and the nasogastric tube was cut at the nares. The image is a photo taken after extubation. The literature describes nasogastric tubes and orogastric tubes that are placed in the tracheobronchial tree resulting in complications such as pneumothorax, enteral feeding hydrothorax, and inadequate ventilation due to tracheobronchial suctioning under ...
A thoracentesis is a procedure that doctors use to drain excess fluid from the space between the lungs and the chest wall. Learn more about a thoracentesis here.
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of interest determined on them is brought about by the inherent tendency of the net rates of interest included in these gross rates toward the final state of originary interest. With regard to this tendency, catallactic theory is free to deal with the market rate of interest as if it were a uniform phenomenon, and to abstract from the entrepreneurial component which is necessarily always included in the gross rates and from the price premium which is occasionally included. - ibid, pg 546.. ---------. So here we have Mises explaining ad nauseum that the natural interest rate he referred to is an imaginary construction only, a mental tool used to understand the non-uniform interest rates that empirically prevail in the market. Now, given that Mises, the originator of the ABCT that Hayek adopted, held that there will always prevail multiple interest rates in the market, the next question is: How can a theory that pedagogically utilizes a single natural interest rate, explain the real world? The ...
of interest determined on them is brought about by the inherent tendency of the net rates of interest included in these gross rates toward the final state of originary interest. With regard to this tendency, catallactic theory is free to deal with the market rate of interest as if it were a uniform phenomenon, and to abstract from the entrepreneurial component which is necessarily always included in the gross rates and from the price premium which is occasionally included. - ibid, pg 546.. ---------. So here we have Mises explaining ad nauseum that the natural interest rate he referred to is an imaginary construction only, a mental tool used to understand the non-uniform interest rates that empirically prevail in the market. Now, given that Mises, the originator of the ABCT that Hayek adopted, held that there will always prevail multiple interest rates in the market, the next question is: How can a theory that pedagogically utilizes a single natural interest rate, explain the real world? The ...
Abstract:. Aim: To study the clinical presentation and outcome in Congenital Diaphragmatic defects. Materials and Methods: Retrospective study of 25 cases of Congenital Diaphragmatic defects including Congenital Diaphragmatic Hernia and Diaphragmatic Eventration admitted in King George Hospital of Andhra Medical College, Visakhapatnam, Andhra Pradesh from 2009 to 2014.Cases of age group from 1 day to 5 years are included in the present study. Results: 21 cases presented with classical clinical presentation, 2 cases with atypical presentation and 2 cases with post-operative recurrences which were operated outside the institution. Cases with Right side Diaphragmatic Hernia and a case with atypical presentation succumbed to death. Conclusions: Congenital Diaphragmatic Hernias are common on left side and carries good prognosis. Cases with atypical clinical presentation have 50% mortality. Right sided Congenital Diaphragmatic Hernias are rare but carries guarded prognosis.. ...
Dipstix examination of the urine showed moderate amounts of blood. Full blood count and serum biochemistry was normal. Chest x ray showed fractures of the eighth and ninth ribs on the left side, and confirmed local subcutaneous emphysema in the soft tissues overlying the fractures. There was no evidence of pneumo/haemothorax or pneumoperitoneum. A computerised tomography (CT) scan of the abdomen was performed, which showed normal solid abdominal viscera with intact spleen and well perfused kidneys. There was some free intraperitoneal gas and fluid. The CT scan again confirmed rib fractures and local emphysema close to the splenic flexure, suggesting colonic perforation. The stomach was distended and appeared intact. Major vessels were intact. Minor posterior atelectasis was noted at the base of the lungs, but there was no pneumothorax or significant pleural effusion. CT scan also showed a fracture of the left transverse process of L4 vertebrae with intact vertebral body and psoas ...
This Light criteria calculator can diagnose pleural effusions as exudates and provide the differentiation criteria from pleural transudates.
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Pleural Effusion, Transudative
What happens during a thoracentesis?. Your doctor will use medical imaging to find the pocket of fluid. After cleaning your back, your doctor will numb your skin. She or he will then place a thin tube into the space surrounding your lungs and drain the fluid through tubing and into a bag. The procedure usually takes a few minutes. Your doctor will remove the tube at the end.. Sometimes it is necessary to leave a little tube in your chest to continue draining fluid or abnormal air around the lungs. This is called a chest tube. ...
Exhibits protein tyrosine kinase activity. Involved in circulatory system development and thyroid gland development. Predicted to localize to the integral component of plasma membrane and receptor complex. Is expressed in several structures, including cardiovascular system; head; hematopoietic system; mesoderm; and pleuroperitoneal region ...
NFPA chapter 15 page 11 to page 15 DESIGN and INSTALLATION clause 4-4.3.2 VESSELS delineates;. (a) These rules for exposure protection contemplate emergency relieving capacity for vessles, based upon a maximum allowable heat input of 6,000 BTU per hour per sg ft (18,930 W/sq m) of exposed surface area. The density shall be increased to limit the heat absorption to a safe level in the event required emergency relieving capacity is not provided.. (b) Water shall be applied to VERTICAL or INCLINED vessel surfaces at a Net Rate of Not less that 0.25 Gallon per minutes per sq ft (10.17 Liter per minute per sq meter) of exposed un-insulated surface ...
TY - JOUR. T1 - Decreases in levels of serum fibronectin predict the severity of vascular leak syndrome in patients treated with ricin A chain-containing immunotoxins. AU - Baluna, Roxana. AU - Sausville, Edward A.. AU - Stone, Marvin J.. AU - Stetler-Stevenson, Mary Alice. AU - Uhr, Jonathan W.. AU - Vitetta, Ellen S.. PY - 1996/10. Y1 - 1996/10. N2 - The major dose-limiting adverse effect of ricin A chain-containing immunotoxin (IT) therapy is vascular leak syndrome (VLS). Since plasma fibronectin (Fn) plays a role in maintaining microcirculatory integrity and since the gradient between plasma and tissue Fn can be altered in various pathological situations, we determined whether the administration of IT-ricin A chain to patients resulted in changes in the levels of serum Fn and, if so, whether these changes correlated with the severity of VLS. We also measured the serum levels of tumor necrosis factor α (TNFα), a proinflammatory cytokine which has been implicated in tissue damage and in ...
The sensitivity and specificity of Lights criteria for detection of exudates have been measured in many studies and are usually reported to be around 98% and 80%, respectively.[17][18] This means that although Lights criteria are relatively accurate, twenty percent of patients that are identified by Lights criteria as having exudative pleural effusions actually have transudative pleural effusions. Therefore, if a patient identified by Lights criteria as having an exudative pleural effusion appears clinically to have a condition that usually produces transudative effusions, additional testing is needed. In such cases albumin levels in blood and pleural fluid are measured. If the difference between the albumin level in the blood and the pleural fluid is greater than 1.2 g/dL (12 g/L), this suggests that the patient has a transudative pleural effusion.[11] However, pleural fluid testing is not perfect, and the final decision about whether a fluid is a transudate or an exudate is based not on ...
Several tests can be performed in the laboratory to determine if a fluid is either a transudate or an exudate. The results of these tests, specifically the chemistries, should be compared with baseline peripheral blood testing in order to determine the whether the results obtained from the fluid sample are normal or abnormal. This is done at the discretion of the clinician as most laboratories do not provide reference ranges for fluids. The major test used to differentiate between a transudate or an exudate is the concentration of total protein in a fluid. Transudates generally have total protein concentration less than 3.0 g/dL while exudates generally have a total protein greater than 3.0 g/dL. Another way of looking at this value is to compare it to the level of total protein found in the patients serum. A transudate will still have a low concentration of total protein while an exudate will generally have a concentration of total protein that is greater than half the concentration of total ...
Recurrent fluid surrounding the lungs is associated with poor quality of life, the main symptom being dyspnea. These patients are in need of recurrent removal of the fluid using drainage. The mechanism causing dyspnea is not fully understood.. By using ultrasound to evaluate the movement of the diaphragm before and after removal of fluid and the patients symptoms before removal of fluid and until next removal the research group aims to clarify the temporal development in symptoms and the role of the diaphragm.. The researchers will also evaluate the ability of the pulmonologist and patient to predict when the patient will need the next removal of fluid in patients with recurrent unilateral pleural effusion. ...
A27 Immunotoxins, a class of biologic therapeutics provide efficacious and specific treatment for cancer as they target surface specific growth factor receptors or antigens over expressed on cancer cells. Immunotoxins have shown promising results in vitro and in vivo. One of the immunotoxin approved for use by FDA is denileukin diftitox; major toxicities with this drug are acute hypersensitivity, vascular leak syndrome and impaired immune function. The latter two toxicities are due to nonspecific binding of immunotoxin to macrophages and activated lymphocytes. We hereby attempted to design an immunotoxin with unaltered efficacy and decreased toxicity. In these immunotoxins, modified diphtheria toxin (DT) acts as cytotoxic moiety and IL-2 as the targeting moiety for cancer cells that over express IL-2 receptor on their surface. IL-2 receptor has three subunits alpha, beta and gamma. Biological effect of IL2 is mediated through IL2 alpha beta gamma receptor and IL2 beta gamma receptor complexes ...
Tension gastrothorax describes a rare life-threatening condition caused by mediastinal shift due to a distended stomach herniating into the thorax through a diaphragmatic defect. Clinical presentation Presentation is generally with acute and s...
The term blow out kit comes from the Military, and refers to a medical kit to treat life threatening wounds… View Article. ...
ALBFL : Aiding in identifying the cause of ascites   Aiding in differentiating exudative and transudative pleural effusions
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