In the present study, we demonstrated that T0901317, a synthetic LXR agonist, suppressed the expression of AT1R at mRNA and protein levels and that cellular response to Ang II was reduced by AT1R suppression. The results of the luciferase assay suggest that the AT1R promoter region that contains the Sp1 binding site is essential for T0901317-induced AT1R suppression. This is the first study reporting the effect of LXR activation on AT1R expression and its molecular mechanism. We also showed for the first time that LXR agonists upregulated p16 and induced dephosphorylation of Sp1, which may inhibit AT1R gene expression.. It was reported that LXRs regulate gene transcription by 2 mechanisms. One is a DNA-dependent pathway that involves binding of liganded LXR to LXR response element of target genes after the formation of heterodimer with the retinoid X receptor.1 The other is an LXR response element-independent pathway that involves interference with other transcription factor pathways.28 Several ...
The report generally describes 2,2,3,3,3-pentafluoro-1-propanol, examines its uses, production methods, patents. 2,2,3,3,3-PENTAFLUORO-1-PROPANOL market
1-[[2-(2,4-dichlorophenyl)-4-(1,1,2,2-tetrafluoroethyl)-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole SD 494A Acetamide, N-(4-(dimethylamino)phenyl)- Urea, N-(2,6-bis(1-methylethyl)phenyl)-N-(2-(1-methyl-1H-indol-3-yl)hexyl)- Benzothiazolium, 3-(3-amino-3-oxopropyl)-2-((4-((2-chloroethyl)ethylamino)phenyl)azo)-6-ethoxy-, (T-4)-tetrachlorozincate(2-) (2:1) 3-(3-Chlorobenzoyl)-4-hydroxy-2(1H)-quinolinone Ergoline-8-methanol,10-methoxy-1,6- dimethyl-,5-bromo-3-pyridinecarboxylate (ester),(8â)-,(2R,3R)-2,3-dihydroxybutanedioate (salt) Phosphoric acid, 2-chloro-1-phenylvinyl diethyl ester 60328-00-9 (2-(o-Tolyloxy)ethyl)guanidine
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for Benzenecarbothioic acid,S-[1,1,3,3,3-pentafluoro-2-(trifluoromethyl)propyl] ester (CAS No. 62753-81-5)
Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(i) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.
LIVER X RECEPTOR AGONISTS IN THE TREATMENT OF EMPHYSEMA | COMBINATION OF IMMUNOTHERAPY WITH LOCAL CHEMOTHERAPY FOR THE TREATMENT OF MALIGNANCIES | Aerosol Formulations Comprising Formoterol Fumarate Dihydrate | COMBINATION CANCER TREATMENT | d-Methadone for the Treatment of Psychiatric Symptoms |
概要该反应是用于在芳香环上导入三氟甲基。该反应中用到的三氟甲基化试剂(Burton试剂)是CF2Br2在DMF中与Zn或Cd反应调配而成,该试剂对热稳定。
Our results demonstrate that LXR agonists induce the expression of the LPS receptor TLR-4 in human but not in murine macrophages. A LXRE site was identified in the human TLR-4 promoter that mediates the transactivation by LXRs/RXRα. The mouse and human TLR-4 genes are highly conserved.31 However, notable differences exist with respect to the elements implicated in gene regulation, which may account for species differences in terms of tissue expression and modulation by different stimuli.28,31 The LXRE site is not conserved between the human and mouse TLR-4 promoters, likely explaining the species-specific regulation of TLR-4 by LXRs. Increased expression of TLR-4 resulted in an enhanced responsiveness of human macrophages to LPS. Indeed, LXR agonist pretreatment enhanced MAPK activation as well as MCP-1 and TNFα secretion in LPS-stimulated human macrophages. Moreover, we show that LXR activation increases ROS production in LPS-activated human macrophages. This effect was also observed in ...
Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3). miRNA has-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA has-miR-613. The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with ...
Purpose: : Diabetes is associated with hypercholesterolemia as well as hyperglycemia which can lead to DR. Liver X receptor (LXR) not only modulates cholesterol but also reduces inflammation and activates the protective arm of the renin-angiotensin system (RAS) through activation of ACE 2, Ang 1-7 and its receptor Mas1. We postulated that LXR activation may serve to correct glucose mediated dysfunction in vitro and improve diabetic retinopathy. Methods: : 661W murine cone cells and ARPE-19 human RPE cells were cultured in media either without (control) or with 5mM and 30 mM Glucose (G-5 and G-30). On the 7th day of glucose treatment, 1µM of LXR agonist-GW3965 hydrochloride (GW) was added to cultures containing glucose (G-5+GW and G-30+GW). On the following day cells were harvested and protein and mRNA expression for LXR α/β, RAS related genes, and iNOS were determined by western blot and quantitative PCR, respectively (n=4). In parallel studies DBA/2J mice made diabetic with streptozotocin ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 873429-59-5(L-Phenylalanine,2,3,5-trifluoro-),please inquire us for 873429-59-5(L-Phenylalanine,2,3,5-trifluoro-).
Potassium p-[2,2,2-trifluoro-1-(p-hydroxyphenyl)-1-(trifluoromethyl)ethyl]phenolate/ACM52870696 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Acetic acid, trifluoro-, 3-phenyl-2-propenyl ester | C11H9F3O2 | CID 576196 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Click here to access the full EPA document in PDF format. The EPA DfE program helps consumers and industrial and institutional purchasers identify products that have been screened against rigorous standards concerning certain environmental characteristics, including aquatic toxicity and biodegradability.. The DfE certification also enables formulators to partner with a credible 3rd party program and verify important attributes of their products.. For more information about the DfE program or to locate materials that are eligible for DfE focused formulations, contact us here.. ...
6-Piperidin-1-yl-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide | C18H25F3N4O | CID 118736793 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Hi, I was hoping to get some insight on the change to 27096 for 2012. This code now includes CT or fluoro guidance, which a number of other codes we u
Retinoic acids regulate the reverse cholesterol transport by inducing the ATP binding cassette transporter A1 (ABCA1) dependent cholesterol efflux in macrophages, neuronal as well as intestine cells. In the present study, we aim to test the effect of all trans retinoic acid (ATRA) on ABCA1 expression in human CD4+ T cells and the involvement of cholesterol in ATRA mediated anti-HIV effect. Treatment with ATRA dramatically up-regulated ABCA1 expression in CD4+ T cells in a time and dose dependent manner. The expression of ABCA1 paralleled with increased ABCA1-dependent cholesterol efflux. This induction was dependent on T cell receptor (TCR) signaling and ATRA failed to induce ABCA1 expression in resting T cells. Moreover, ATRA and liver X receptor (LXR) agonist-TO-901317 together had synergistic effect on ABCA1 expression as well as cholesterol efflux. Increased ABCA1 expression was associated with lower cellular cholesterol staining. Cells treated with either ATRA or TO-901317 were less vulnerable to
Circ Res. 2004 Dec 10;95(12):e110-23. Epub 2004 Nov 11. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S.
INTRODUCTION: Liver × receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors and have established functions as regulators of cholesterol, glucose, and fatty acid metabolism and inflammatory responses. Published reports of anti-proliferative effects of synthetic LXR ligands on breast, prostate, ovarian, lung, skin, and colorectal cancer cells suggest that LXRs are potential targets in cancer prevention and treatment.. METHODS: To further determine the effects of LXR ligands and identify their potential mechanisms of action in breast cancer cells, we carried out microarray analysis of gene expression in four breast cancer cell lines following treatments with the synthetic LXR ligand GW3965. Differentially expressed genes were further subjected to gene ontology and pathway analyses, and their expression profiles and associations with disease parameters and outcomes were examined in clinical samples. Response of E2F target genes were validated by ...
Preface xvii. 1 Solid Propellants and Their Combustion Characteristics 1. 1.1 Background of Solid Propellant Combustion, 4. 1.1.1 Definition of Solid Propellants, 4. 1.1.2 Desirable Characteristics of Solid Propellants, 4. 1.1.3 Calculation of Oxygen Balance, 5. 1.1.4 Homogeneous Propellants, 6. 1.1.4.1 Decomposition Characteristics of NC, 6. 1.1.5 Heterogeneous Propellants (or Composite Propellants), 7. 1.1.6 Major Types of Ingredients in Solid Propellants, 8. 1.1.6.1 Description of Oxidizer Ingredients, 10. 1.1.6.2 Description of Fuel Binders, 12. 1.1.6.3 Curing and Cross-Linking Agents, 14. 1.1.6.4 Aging, 15. 1.1.7 Applications of Solid Propellants, 16. 1.1.7.1 Hazard Classifications of Solid Propellants, 16. 1.1.8 Material Characterization of Propellants, 16. 1.1.8.1 Propellant Density Calculation, 16. 1.1.8.2 Propellant Mass Fraction, 17. 1.1.8.3 Viscoelastic Behavior of Solid Propellants, 17. 1.1.9 Thermal Profile in a Burning Solid Propellant, 18. 1.1.9.1 Surface and Subsurface ...
The infra-red intensities of the fundamental vibration bands of the four methyl halides have been measured, using the method involving pressure broadening of bands described by Wilson. The force constants have been determined on the basis of a force field previously suggested by Noether, and the transformations from normal to symmetry co-ordinates have been calculated. After allowing for the effects of the overlapping of bands and of Fermi resonance, the intensities have been interpreted in terms of bond moments μ and of their derivatives ∂μ/∂r, assumed to be vectors directed along the bonds. The results show that values of ∂μ/∂r CH obtained from the A1 class of vibration vary from about 1⋅7 x 10-10 unit (Debye/Å) for methyl fluoride to about 0⋅9 x 10-10 for methyl iodide showing a uniform trend along the series. By contrast, the values in the E class range from about 0⋅6 x 10-10 for methyl fluoride to less than 0⋅2 x 10-10 for the iodide. Values of μCH in general lie around ...
Liver X receptors (LXRs) α (NR1H3) and β (NR1H2) are nuclear receptors that have been involved in the regulation of many physiological processes, principally in the control of cholesterol homeostasis, as well as in the control of the cell death and proliferation balance. These receptors are thus promising therapeutic targets in various pathologies such as dyslipidemia, atherosclerosis, diabetes and/or cancers. These receptors are known to be activated by specific oxysterol compounds. The screening for LXR-specific ligands is a challenging process: indeed, these molecules should present a specificity towards each LXR-isoform. Because some natural products have significant effects in the regulation of the LXR-regulated homeostasis and are enriched in flavonoids, we have decided to test in cell culture the effects of 4 selected flavonoids (galangin, quercetin, apigenin and naringenin) on the modulation of LXR activity using double-hybrid experiments. In silico, molecular docking suggests specific binding
We have developed a transplantation-based mouse model of atherosclerosis regression by allowing plaques to form in apoE−/ − mice, then changing the plaques plasma environment from hyperlipidemia to normolipidemia. In this model, we reported emigration of plaque foam cells to regional and systemic lymph nodes after 3 days in the regression environment (Llodrá et al. PNAS 2004). This emigration required the expression of the chemokine receptor CCR7 on the foam cells and was associated with up-regulation of their LXR mRNA (Trogan, Feig et al. PNAS 2006). Because the human and murine promoters have LXREs, we hypothesized that LXR was a regulator of CCR7. Using a murine model of immature DCs, D2.4 cells, we found that CCR7 expression is increased 8 -9X upon LXR activation by the agonist T0901317 (T09). Importantly, this increase is dependent on CCR7 gene transcription, because pre-treatment with actinomycin D abolished the observed response. When siRNA to LXR alpha and LXR beta was used in ...
1,2,4-Trifluoro-5-nitrobenzene 2105-61-5 route of synthesis, 1,2,4-Trifluoro-5-nitrobenzene chemical synthesis methods, 1,2,4-Trifluoro-5-nitrobenzene synthetic routes ect.
Zhang, X.; Even-Or, O.; Xu, X.; Rosmalen, M.; Lim, L.; Gadde, S.; Farokhzad, O.; Fisher, E. A. "Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis" Adv. Healthcare Mater.2014 (in press). Wu, J.; Kamly, N.; Shi, J.; Zhao, L.; Xiao, Z.; Hollett, G.; John, R.; Ray. S.; Xu, X.; Zhang, X; Kantoff, P.; Farokhzad C. O. "Development of multinuclear polymeric nanoparticles as robust protein nanocarriers" Angew. Chem. Int. Ed. 2014 (in press). Shi, J.; Xu, Y.; Xu, X.; Zhu, X.; Pridgen, E.; Votruba, A.; Zetter, B.; Farokhzad C. O. "Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing"Nanomed Nanotech Biol Med 2014 (in press). Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N.; Farokhzad, C. O. "Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology" Adv. Drug Deliv. Rev. 2014; 66, 2-25.. Xu, X; Xie, K; Zhang, X; Pridgen, E; Park, G; Lippard, S. J.; Langer, R. S.; Walker G. C.; Farokhzad C. O. ...
Novel spherical grain-binding, high-burning-rate propellant is a kind of compound structure propellant (called a consolidated propellant) that is prepared using...
This page contains information on the chemical Pyridinium, 1-(6-hydroxy-4-oxo-7,7,7-trifluoro-6-(trifluoromethyl)heptyl)-, chloride including: 2 synonyms/identifiers.
Some years ago while dissecting what I felt to be a particularly ingenious handheld propellant sprayer in order to see how it worked, I became aware that it contained an oily residue which could be of concern if used in certain treatment applications. Only recently I became aware that paper conservators were using a similar disposable propellant canister for spray applications of deacidifying reagents on works of art. Procedural questions had also been raised about the cause of yellowing which accompanied some, but not all, methods of application of the same reagent. It quickly became clear that these canisters also possessed oil in the propellant reservoir. While the oil did not seem to have caused the observed yellowing in this particular case, conservators should consider that staining may be caused by the unknown contents of such propellant systems. Such problems are easily identified. A canister of the propellant should be completely discharged, without anything attached to the aspirator, ...
methyl (E,4E)-5,5,5-trifluoro-4-(4-methylphenyl)iminopent-2-enoate - C13H12F3NO2, synthesis, structure, density, melting point, boiling point
Thank you for sharing this Molecular Pharmacology article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
Intradermally administered ATP elicits pain in humans under normal conditions and enhances inflammatory-mediated pain (Bleehen and Keele, 1977; Hamilton et al., 2000) by exciting both mechanoresponsive and mechanoinsensitive C-fibers (Hilliges et al., 2002). Experimentally, the nociceptive effects of intradermally administered P2X receptor agonists [e.g., ATP, α,β-methyleneATP (α,β-meATP), and BzATP; Fig. 1] are short-lasting (1-10 min) and similar in magnitude compared with that produced in the acute phase of the standard formalin test, a neurogenic inflammatory pain model in rodents (Jarvis et al., 2001). As has been observed in humans, both the potency and effectiveness of locally administered P2X receptor agonists to elicit nociceptive responses are increased in situations of peripheral inflammation-induced neuronal sensitization (Hamilton et al., 2000; Sawynok, 2007). Stimulation of spinal P2X receptors may also contribute to nociception as indicated by the ability of i.t. administered ...
The CSPA Aerosol Propellants Safety Manual is the basic safety manual needed by all aerosol product manufacturers and laboratories.
NSC 9135 - Liquid Propellant Fuels and Oxidizers, Chemical Base, including description, included items, excluded items and related part numbers and NSN starting at Page 1.
Fullscreen (supported by IE11, latest versions of Firefox, Chrome, Safari (not including iOS Safari), Edge, Chrome for Android, Samsung Internet) ...
Details of the structure, physical properties and bioactivities of 2,2-Dichloro-1,1,2-trifluoroethyl difluoromethyl ether from the molfield.org Anesthetic Structure Database.
Cell growth inhibition assay and data analysis Cells were plated at appropriate density in 96 very well plates such they would remain in log growth with the finish of assay time. The cells had been allowed to attach overnight before getting exposed to Mek inhibitor CI 1040, UO126 or GSK1120212 for 72 h. Medication have been dissolved in dimethyl sulfoxide as 10 mM stock, and a set of 9 doses in 1,5 serial dilution was added in tripli cate wells. The last DMSO concentration from the taken care of well was 0. 3% or much less. The cell development was established utilizing Cell Titer Glo assay, with slight modification from the producers protocol at day 0 and day 3 of drug publicity. Briefly, Cell Titer Glo reagent was diluted with phosphate buffered saline as well as culture media was eliminated in the 96 well plate prior to including 50 ?l per well from the diluted Cell Titer Glo rea gent.. Luminescence in the assay was recorded making use of BIO TEK FLx800. Data calculations were manufactured in ...
The reaction of enol esters with SelectFluor is facile and leads to the corresponding α-fluoroketones under mild conditions and, as a result, this route is commonly employed for the synthesis of medicinally important compounds such as fluorinated steroids. However, despite the use of this methodology in synthesis, the mechanism of this reaction and the influence of structure on reactivity are unclear. We present a rigorous mechanistic study of the fluorination of these substrates, informed primarily by detailed and robust kinetic experiments. The results of this study implicate a polar two-electron process via an oxygen-stabilised carbenium species, rather than a single-electron process involving radical intermediates. The structure/reactivity relationships revealed here will assist synthetic chemists in deploying this type of methodology in the syntheses of α-fluoroketones. ...
Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe). Solaas K, Legry V, Retterstol K, Berg PR, Holven KB, Ferrières J, Amouyel P, Lien S, Romeo J, Valtueña J, Widhalm K, Ruiz JR, Dallongeville J, Tonstad S, Rootwelt H, Halvorsen B, Nenseter MS, Birkeland KI, Thorsby PM, Meirhaeghe A, Nebb HI. BMC Med Genet. 2010 Oct 12;11:144 ...
definition of - SB 52: HFA(1),(2); SB 55: HFA (1),(2); SB 92: HFA (1),(2); SB 135: HFA (2),(3); SB 146: HFA (1),(2); SB 187: HFA (1),(2); SB 200: HFA (1),(2); SB 245: HFA (7) ...
Duolin HFA is a medicine available in a number of countries worldwide. A list of US medications equivalent to Duolin HFA is available on the Drugs.com website.
Salburex HFA is a medicine available in a number of countries worldwide. A list of US medications equivalent to Salburex HFA is available on the Drugs.com website.
Do you really want to delete this prezi? Neither you, nor the coeditors you shared it with will be able to recover it again. DeleteCancel ...
Rat liver mitochondrial aspartate aminotransferase (a homodimer) was shown to catalyse a β-lyase reaction with three nephrotoxic halogenated cysteine S-conjugates [S-(1,1,2,2-tetrafluoroethyl)-l-cysteine, S-(1,2-dichlorovinyl)-l-cysteine and S-(2-chloro-1,1,2-trifluoroethyl)-l-cysteine], and less effectively so with a non-toxic cysteine S-conjugate [benzothiazolyl-l-cysteine]. Transamination competes with the β-lyase reaction, but is not favourable. The ratio of β elimination to transamination in the presence of S-(1,1,2,2-tetrafluoroethyl)-l-cysteine and 2-oxoglutarate is ,100. Syncatalytic inactivation by the halogenated cysteine S-conjugates is also observed. The enzyme turns over approx. 2700 molecules of halogenated cysteine S-conjugate on average for every monomer inactivated. Kidney mitochondria are known to be especially sensitive to toxic halogenated cysteine S-conjugates. Evidence is presented that 15-20% of the cysteine S-conjugate β-lyase activity towards ...
Liver X receptors (LXR) are deemed as potential drug targets for atherosclerosis, whereas a role in adipose tissue expansion and its relation to insulin sensitivity remains unclear. To assess the metabolic effects of LXR activation, C57BL/6 mice on a high-fat diet (HFD) were treated with the dual LXRα/β agonist T0901317 (30 mg/kg per day) for 3 weeks. Differentiated 3T3-L1 was used for analysing the effect of T0901317 on glucose uptake.T0901317 reduced fat mass, accompanied by a massive fatty liver and lower adipokine levels in circulation of HFD mice. Increased adipocyte apoptosis and macrophage infiltration were found in epididymal fat of T0901317-treated HFD mice. In addition, T0901317 treatment promoted basal lipolysis, but blunted the anti-lipolytic action of insulin. Furthermore, LXR activation antagonized PPARγ target genes in epididymal fat and PPARγ-PPRE binding activity in 3T3-L1 adipocytes. Although the glucose tolerance was comparable to that in vehicle-treated HFD
Early buyers will receive 10% customization on reports.. Aerosol Propellant: The global aerosol propellant market was valued at USD 5.70 Billion in 2014 and is expected to reach USD 8.16 Billion by 2020, at a CAGR of 6.17% from 2015 to 2020.. Europe The most dominant region in the aerosol propellant market. The aerosol propellant market in Europe accounted for the largest share of 37.22%, by volume, of the global aerosol propellant market in 2014. The European market is expected to register the largest share by 2020 owing to the increasing demand of personal care and homecare products, such as antiperspirants, hair gels, air fresheners, and other products from developing countries, such as India and China. Also, major propellant manufacturers are based in Europe, such as Akzo Nobel N.V. (The Netherlands), Arkema Group (France), Royal Dutch Shell (The Netherlands), and others. They manufacture and supply propellants to the personal care and homecare product manufacturing companies, such as ...
this study is to compare GW815SF [salmeterol/fluticasone-propionate] HFA MDI [hydrofluoroalkane metered-dose inhaler] with concomitant treatment with salmeterol
The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines ...
The DABCO-catalyzed reaction of propargyl alcohols with methyl 2-perfluoroalkynoate to give trifluoromethylated furans in up to 98% yield under mild conditions has been developed. The established allene-enol and control experiments indicate that the reaction should proceed through a Michael addition and Claisen rearrangement/cyclization process ...
The ballistic properties of RDX-based propellants are highly dependent on the particle size of RDX used. The effect of RDX particle size on the burning rate and pressure exponent of the gun propellant was studied. Propellant formulation containing RDX to extent of 60 per cent in the composition was processed with varying particle size of RDX. Finished propellants in heptatubular and cord geometry were evaluated for ballistic aspects by closed vessel firing in a 700 cc vessel at a loading density of 0.18 g/cc. The data obtained clearly indicate that increase in particle size of RDX increases the burning rate as well as the pressure exponent ...