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Most of the information presented here is summarized in a table located at the end of this section.. Hydrazine sulfate has been studied extensively in patients with advanced cancer. These studies have evaluated the following: a) tumor response and/or survival among patients with various types of cancer,[1,2,3,4,5,6,7,8,9,10,11,12,13] b) changes in body weight,[1,2,3,4,5,6,8,10,11,12,14] c) carefully measured quality of life,[4,5,6,15] and d) changes in nutritional or metabolic status.[1,4,12,13,16,17]Clinical studies of hydrazine sulfate have been funded by a pharmaceutical company,[3] the Russian government,[7,9,10,18] and by grants from the National Cancer Institute (NCI).[1,2,4,5,6,8,11,12,15,16] They have also been sponsored by the North Central Cancer Treatment Group (NCCTG) [5,6] and the Cancer and Leukemia Group B (CALGB).[4,15]. The first clinical tests of hydrazine sulfate as a treatment for cancer were conducted in the mid-1970s by a pharmaceutical company.[3] In an uncontrolled study ...

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Hydrophobic polystyrene is the most common material for solid phase immunoassay. Proteins are immobilized on polystyrene by passive adsorption, which often causes considerable denaturation. Biological macromolecules were found to better retain their functional activity when immobilized on hydrophilic materials. Polyacrylamide is a common material for solid-phase carriers of biological macromolecules, including immunoreagents used in affinity chromatography. New macroformats for immunoassay modified with activated polyacrylamide derivatives seem to be promising. New polymeric matrices for immunoassay in the form of 0.63-cm balls which contain hydrazide functional groups on hydrophilic polymer spacer arms at their surface shell are synthesized by modification of aldehyde-containing polystyrene balls with hydrazide derivatives of poly(meth)acrylic acid. The beads contain up to 0.31 μmol/cm2 active hydrazide groups accessible for covalent reaction with periodate-oxidized antibodies. The matrices obtained

Synthesis of ferrocenyl-substituted pyrazoles via the reaction between (2-formyl-1-chlorovinyl)ferrocene and hydrazine derivatives is described. Depending upon the substitution pattern of hydrazine, the reaction affords 1-alkyl/aryl-5-ferrocenylpyrazoles and/or 1-alkyl/ aryl-3-ferrocenylpyrazoles. The reaction appears to be general for a variety of hydrazine derivatives. (c) 2007 Elsevier B.V. All rights reserved. ...

함은 폐재의 리싸이클링을 위한 연구의 일환으로써 Hydrazine Hydrate을 환원제로 사용하여 질산은 수용액으로부터 Ag 나노분말을 제조하기 위한 실험을 수행하였다. 이를 위해 질산은을 소정 농도로 증류수에 용해시킨 수용액에 Ag 미립자의 응집방지를 위한 분산제로써 Tamol NN8906 혹은 Tween 20을 미리 혼합한 다음 환원제인 Hydrazine Hydrate 용액을 첨가하는 방법으로 환원반응을 실시하였다. 환원반응을 통하여 제조한 Ag 미립자는 입도분석기 및 TEM 측정을 통하여 형상과 평균입도를 측정하였다. Hydrazine Hydrate에 의한 은의 환원을 위해서는 이론치의 약 2배를 첨가해 주어야 하는 것으로 나타났으며, Tamol NN8906을 분산제로 사용하여 제조한 Ag 나노분발은 매우 좁은 입도범위의 분포특성을 보여 주었다. Tween 20을 분산제로 사용한 경우의 입도 분포는 bimodal 혹은 multimodal

Hydrazine sulfate has many uses, but most notably, its been used under the trade name of Sehydrin, a treatment for anorexia, cachexia and some even think cancer. But for we DIY chemists, its useful for something entirely different- as a substitute for the more dangerous pure liquid hydrazine in chemical reactions. NurdRage shows you how to make it via some hypochlorite and the Ketazine process. Warning: The reaction produces toxic gases and products and uses corrosive chemicals; gloves must be worn. Simply adding in a stoichiometric amount of base will release the hydrazine in-site and

Hydrazine - a colorless liquid.Hydrazine hydrate - a colorless liquid, fuming in the air with a smell like ammonia.MPC for hydrazine and its derivatives - 0.1 mg / m3.Hydrazine and its compounds are used in the production of plastics, rubber, pesticides, as part of jet fuel, as antioxidants in rubber and metal industry (for protection against corrosion of metals), and so on. N. enters the body through the respiratory system and skin.Is cumulative.Irritant to skin and mucous membranes.Affects the central nervous system, internal organs, especially the liver, the blood system.. ...

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Import Data And Price Of HYDRAZINE , www.eximpulse.com Eximpulse Services will provide you the latest and relevant market intelligence reports of HYDRAZINE Import Data. You can find live data of maximum number of ports of India which is based on updated shipment data of Indian Customs. Only previous two days data will be seen on website. You can use this HYDRAZINE import data for multiple kinds of analysis; lets say Import price, Quantity, market scenarios, Price trends, Duty optimization and many more. You can go through some of the sample shipment records for HYDRAZINE import data mentioned above. Here on Eximpulse Services you will get all kind of free sample as well as detailed reports of Export/ Import data as per your requirement. To get in touch for any kind of enquiry related to free sample or detailed report contact on +91-120-408-4957, +91-120-408-4958,+91-120-428-4019.. Data post 2012 as per Notification No.18/2012 - Customs(N.T.) and does not have names of Indian companies and ...

By Nayak, Tapan K Hathaway, Helen J; Ramesh, Chinnasamy; Arterburn, Jeffrey B; Dai, Donghai; Sklar, Larry A; Norenberg, Jeffrey P; Prossnitz, Eric R Breast and endometrial cancers are the most common invasive malignancies in women, with more than 217,000 new diagnoses per year in the United States. These cancers are often classified into 2 subtypes based on the expression of the classical estrogen receptor. In this study, we describe a new structural class of neutraf tridentate ^sup 99m^Tc(I)-estradiol-pyridin-2-yl hydrazine derivatives for potential use in breast and endometrial cancer imaging. Methods: The ^sup 99m^Tc(I)-estradiol-pyridin-2-yl hydrazine derivative was synthesized via the Sonogashira cross- coupling reaction and radiolabeled via the tricarbonyl approach. Radiochemical purity was assessed by high-performance liquid chromatography. Cell-binding studies were performed with human breast adenocarcinoma MCF-7 cells. The in vivo biodistribution of the ^sup 99m^Tc(I) derivative was ...

NOTE: The information in this summary is no longer being updated and is provided for reference purposes only. This cancer information summary provides an overview of the use of hydrazine sulfate as a treatment for people with cancer. The summary includes a brief history of hydrazine sulfate research, results of clinical...

This trial will compare the efficacy and tolerability of cytarabine [cytosine arabinoside] with or without laromustine [Cloretazine, VNP40101M] in patients with

In this study, seventeen novel quinoline-based carboxylic hydrazides were designed as potential anti-tubercular agents using molecular hybridization approach and evaluated in-silico for drug-likeness behavior. The compounds were synthesized, purified, and characterized using spectral techniques (like FTIR, (1) H NMR, and Mass). The in-vitro anti-tubercular activity (against Mycobacterium tuberculosisH37Ra) and cytotoxicity against human lung fibroblast cells were studied. Among the tested hydrazides, four compounds (6h, 6j, 6l, and 6m) exhibited significant anti-tubercular activity with MIC values below 20 μg/mL. The two most potent compounds of the series, 6j and 6m exhibited MIC values 7.70 and 7.13 μg/mL, respectively, against M. tuberculosis with selectivity index |26. Structure-activity relationship studies were performed for the tested compounds in order to explore the effect of substitution pattern on the anti-tubercular activity of the synthesized compounds.

Title:Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety. VOLUME: 13 ISSUE: 2. Author(s):Seref Demirayak, Ismail Kayagil, Leyla Yurttas and Sevda Er. Affiliation:Department of Pharmaceutical Chemistry School of Pharmacy Medipol University 34810 Istanbul Turkey.. Keywords:Salicylidene hydrazide, 1, 2, 4-triazole, antifungal activity.. Abstract:A series of new N-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1- 16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4- substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven different Fusarium, ...

Laromustine is an experimental sulfonylhydrazine prodrug used in late-stage clinical studies against acute myeloid leukemia (AML) and glioblastoma multiforme (GBM). Despite initial promise for both indications, clinical trials for GBM have not been as successful as those for AML. To investigate methods for improving the effectiveness of laromustine in GBM and to learn more about the mechanism of action of laromustine, a chemical genetic screen will be conducted to identify agents that sensitize GBM cells to the anti-proliferative effects of laromustine. The library, which will include approximately 450 FDA-approved drugs, will be screened using a newly optimized high throughput assay based on the Click-iT EdU Microplate Assay kit (Molecular Probes). Optimization of the assay has required determining the proper cell seed density, drug concentration and incubation time, and fluorescent substrate concentration, among other variables. It was determined that low cell seed densities allow for maximal

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Ultimately, this is because of the enormous amount of energy stored in the propellants required to make a rocket fly. Ground support personnel need to exercise great care even when dealing with safe propellants, such as the classic combination of kerosene and liquid oxygen. On the other end of the spectrum you have chemicals that are so unstable and toxic that they cant be handled without special training and equipment.. One of the most dangerous chemicals ever used in rocket propulsion is hydrazine; and yet from the Second World War to the present day, its been considered something of an occupational hazard of spaceflight. While American launch vehicles largely moved away from using it as a primary propellant, hydrazine is still commonly used for smaller thrusters on spacecraft.. When SpaceXs Crew Dragon exploded in April during ground tests, the release of approximately one and a half tons of hydrazine and nitrogen tetroxide propellants required an environmental cleanup at the ...

Breathing zone samples were analyzed for hydrazine (302012) and ammonia (7664417) at Olin Corporation Chemicals Group (SIC-2869), Lake Charles, Louisiana in February, 1984. The purpose of the survey was to measure occupational exposures to hydrazine during its production by the ketazine process as part of a NIOSH industrywide survey of exposure to hydrazine compounds. Ventilation measurements were

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These studies indicate that laromustine readily undergoes base-catalyzed (nonenzymatic) conversion to methylisocyanate and 90CE, which further degrade to additional chloroethylating derivatives. Figure 1B shows the proposed formation of decomposition/metabolite product pathways of laromustine formed in in vitro systems. The rate at which [14C]laromustine (100 μ M) produces its metabolites/degradation products in the presence of NADPH-fortified HLMs was essentially the same as that in the absence of NADPH or the presence of boiled (heat-denatured) microsomes. Additionally, it remained consistent with the nonenzymatic rate of laromustine degradation in potassium phosphate buffer (Nassar et al., 2009). This suggests that laromustine metabolism/degradation is not significantly affected by human liver microsomal P450 enzymes and carboxylesterases.. Only the formation of C-7 required the presence of NADPH. C-7 appears to be decomposed or metabolized further, which suggests that P450 is a factor in ...

Preferred Name: Laromustine Definition: A sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits O6-alkyl-guanine transferase, an enzyme involved with DNA repair. NCI-GLOSS Definition: A drug used to treat acute myelogenous leukemia (AML). It is also being studied in the treatment of several other types of cancer. It blocks cell growth by damaging the cells DNA and may kill cancer cells. It is a type of alkylating agent. Display Name: Laromustine Label: Laromustine NCI Thesaurus Code: C2653 (Search for linked caDSR metadata) (search value sets) NCI Metathesaurus Link: C2713559 (see NCI Metathesaurus info) Synonyms & Abbreviations: (see Synonym Details) ...

thieno(2,3-d)pyrimidin-4-one acylhydrazide: moderately potent inhibitor of TGase 2 (tissue transglutaminase); structure in first source

In Figure 1, (1) represents a distillation column into which azine is introduced at the top of the column via the pipe (2) and water is introduced via the pipe (4). A fraction of the water supplied via the pipe (3) is sent via the pipe (5) to an exchanger (6) and then fed, in the form of vaporized water, into the bottom of the column (1). The hydrazine produced is removed from the bottom of the column via the pipe (7). A fraction of this hydrazine is deviated via the column and sent to a pump (9) and then to an exchanger (10) before being reinjected at a higher temperature into the bottom of the column (1). A ketone/water azeotrope and inert gases are removed from the top of the column (1) via the pipe (11) and are separated, after passage through an exchanger (12). The ketone/water azeotrope liquid fraction is partially recycled via the pipe (14) into the top of the column (1 ...

Hydrazine, a mainstay fuel of the space program since the early days, now has a competitor that is easier to store and - when taking all costs into account - is the same price.. A subsidiary of the Swedish Space Corp., called ECAPS, has been developing a High Performance Green Propulsion (HPGP) fuel that is based on ammonium dinitrimide.. Its exhaust gases are benign: water, nitrogen, hydrogen, carbon dioxide. Its so safe to store that it has a rating in both the European Union and the United States to carry in the cargo area of commercial aircraft, greatly lessening the cost of transportation.. HPGPs advantage over its competitors is its flight experience, said ECAPS president Mathias Persson in an exclusive interview with SpaceRef at the National Space Symposium in Colorado Springs. The fuel is flying aboard an orbiting demonstration satellite set, called Prisma, that is comparing HPGP and hydrazine performance in orbit. Its been in orbit nearly two years.. Were seeing eight per cent ...

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The Toronto Star has reported that the Darlington nuclear power plant, site of 4 CANDU reactors, accidentally released over 50,000 gallons of water contaminated with radioactive tritium and toxic hydrazine into Lake Ontario. Predicatbly, the Ontario nuclear utility has downplayed any health risks. But documents on Beyond Nuclears and NIRS websites show that tritium, whether released into the environment routinely as part of daily operations, or accidentally via spills or leaks, cannot only cause cancer, but other maladies such as birth defects and genetic damage. For its part, hydrazine is so toxic that the U.S. military justified its shooting down of a listless satellite in order to prevent the toxin on board from reaching the Earths surface, as reported by National Public Radio in early 2008.. ...

Elesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to strongly enhance the efficacy of certain chemotherapy agents, with minimal additional toxicity, at moderate doses. It is being developed by Synta Pharmaceuticals.

N-[(1Z)-{4-[methyl(4-methylphenyl)amino]phenyl}methylidene]-1-{[3-(trifluoromethyl)phenoxy]methyl}-1H-pyrazole-3-carbohydrazide

4-Amino-6-ethoxy-1,3,5-triazine-2-carbohydrazide | C6H10N6O2 | CID 588381 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

In the title carbohydrazide, C10H7N3O4S, the dihedral angle between your terminal five-membered bands is 27. both N2C6C7O2 and S1C1C5O1 torsion sides of ?9.8?(5) and 5.4?(6), respectively; the dihedral position between your five-membered rings is certainly 27.4?(2). Body 1 The mol-ecular framework of (I), displaying displacement ellipsoids on the 70% possibility level. Supra-molecular features ? The partnership between your carbonyl-O and amide-H atoms allows the forming of directional NH?O hydrogen bonds resulting in supra-molecular stores, generated with a 41 screw-axis propagating along the and Desk?1 ?. The 518-82-1 stores are connected right into a three-dimensional structures by thienyl-CH?O(nitro) and furanyl-CH?O(nitro) inter-actions, relating to the equal nitro-O4 atom, Desk?1 ?. Furthermore, C inter-actions are produced between your two five-membered bands using the inter-centroid length getting 3.515?(2)??, as well as the position of inclination is certainly 3.9?(2) for symmetry ...

2-(3-Fluorophenyl)pyrimidine-5-carbohydrazide | C11H9FN4O | CID 100118116 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Learn more about quinoline-6-carbohydrazide. We enable science by offering product choice, services, process excellence and our people make it happen.

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QY Research Reports described a depth and professional market study and forecast trends on Global And China Hydrazine Hydrate Industry 2014 Market Research Report. This report also includes more info about basic overview of the industry including definitions, applications and industry china structure.. ...

Abstract. CuI/4-hydroxy-l-proline-catalyzed coupling of aryl bromides and N-Boc hydrazine takes place in DMSO to give N-aryl hydrazides. When aryl iodides are employed, no ligand is required. Under the catalysis of CuI/4-hydroxy-l-proline, the coupling reaction of aqueous ammonia with aryl bromides proceeds smoothly to afford primary arylamines.. ...

Summary and scientific review by the University of Texas Center for Alternative Medicine Research in Cancer http://www.sph.uth.tmc.edu/utcam/summary/hydrazine.htm ...

Title:Studies on Chemistry, Spectroscopy and Antioxidant Activities of Chromium(III)-Hydrazide Complexes. VOLUME: 11 ISSUE: 8. Author(s):Bushra Shamshad, Rifat A. Jamal, Uzma Ashiq, Mohammad Mahrooof-Tahir, Zara Shaikh, Sadaf Sultan and Khalid M. Khan. Affiliation:Department of Chemistry, University of Karachi, Karachi-75270, Pakistan.. Keywords:DPPH radical, superoxide, nitric oxide, antioxidants, chromium(III)-hydrazide complex.. Abstract:Acid hydrazides are vital chemical entities due to their biological activities. Upon complexation with certain metal ions, their biological activities are known to be positively enhanced. The present work describes the synthesis of Cr(III)-hydrazide complexes, and their structural, spectroscopic and antioxidant properties to reveal their chemistry and biochemistry. Physical (magnetic moment, conductivity measurements), analytical (C, H, N and Cr analysis) and spectral (EI-Mass, FTIR) techniques are used for the characterization of synthesized compounds. All ...

149194-25-2 - ZMDLBLZFZSHVLH-UHFFFAOYSA-N - 1-Acetyl-1,2-bis(methylsulfonyl)-2-(2-chloroethyl)hydrazine - Similar structures search, synonyms, formulas, resource links, and other chemical information.

Q: What were the results of this study, which looked at eltrombopag versus placebo in patients with chronic liver disease and thrombocytopenia?. A: Treatment with eltrombopag at a dose of 75 mg once daily for 14 days reduced the need for platelet transfusions in patients with chronic liver disease and thrombocytopenia who were undergoing elective invasive procedures. Platelet counts were increased during treatment with eltrombopag and for up to 2 weeks after treatment. The key secondary end point of noninferiority with regard to the rate of bleeding episodes (with a noninferiority margin of 10 percentage points) was met (23% in the placebo group and 17% in the eltrombopag group; absolute difference, -6 percentage points; 95% CI, -15 to 3).. Q: How did serious adverse events differ in the two study groups?. A: An increased risk of portal-vein thrombosis was observed among patients receiving eltrombopag. Thrombotic events occurred in 6 patients (7 events) in the eltrombopag group and 2 patients (3 ...

You are viewing an interactive 3D depiction of the molecule 2-(1-(hydrazino(imino)methyl)hydrazino)acetic acid (C3H9N5O2) from the PQR.

My father was diagnosed with Stage IV bladder cancer on Feb. 14,1997 at M.D. Anderson. Original plan was to remove bladder - approximately 18 hour surgery. Three hours later doctor came out to tell us that the cancer had spread throughout the lymph nodes. He decided not to remove the bladder and leave him alone. Given maybe six weeks to live. Within four days after the surgery, he was on hydrazine sulfate (dosage as indicated), Essiac (three times a day instead of two). Tripled the indicated dosage for: Chloro Plasma (credited for building immune system), Red Clover (credited for building the blood) and pure shark cartilage. He took the above from February 18 - May 10 (approximately 3 months) along with two series of Chemo. We returned to M.D. Anderson on May 11,1997. He had all pertinent tests run and results indicated the cancer was gone. We returned home for two more series of Chemo and returned to Houston in July. At this point they performed a surgery that scrapes the lining of the bladder. ...

A ruthenium(iii) complex of N,N′-bis(salicylidene)ethylenediamine (L1) was prepared to give a compound of composition [RuL1(H2O)(PPh3)]PF6, which was examined using spectroscopic methods and single-crystal X-ray diffraction analysis. The geometric analysis was accomplished by DFT studies, which enabled a com

Elesclomol (STA-4783), N-malonyl-bis (N-methyl-N-thiobenzoylhydrazide) is a new chemical entity with a novel structure. STA-4783 induces an oxidative stress response in cells. This response is characterized by increased production of gene families that protect against different cellular stresses, including excessive heat, the presence of reactive oxygen species such as oxygen radicals, or the presence of heavy metals.. Subjects will participate in up to 2 weeks of screening during which time they will complete all screening procedures. Eligible subjects who have not received any prior cytotoxic chemotherapeutic agent for melanoma will be randomized in a 1:1 ratio to receive either STA-4783 213 mg/m2 in combination with paclitaxel 80 mg/m2 or paclitaxel 80 mg/m2 alone.. One treatment cycle will consist of weekly treatments for 3 weeks, followed by a 1-week rest period. Cycles will be repeated every 4 weeks until disease progression. Tumor assessments will be performed every 8 weeks from the ...

Elesclomol (STA-4783), N-malonyl-bis (N-methyl-N-thiobenzoylhydrazide) is a new chemical entity with a novel structure. STA-4783 induces an oxidative stress response in cells. This response is characterized by increased production of gene families that protect against different cellular stresses, including excessive heat, the presence of reactive oxygen species such as oxygen radicals, or the presence of heavy metals.. Subjects will participate in up to 2 weeks of screening during which time they will complete all screening procedures. Eligible subjects who have not received any prior cytotoxic chemotherapeutic agent for melanoma will be randomized in a 1:1 ratio to receive either STA-4783 213 mg/m2 in combination with paclitaxel 80 mg/m2 or paclitaxel 80 mg/m2 alone.. One treatment cycle will consist of weekly treatments for 3 weeks, followed by a 1-week rest period. Cycles will be repeated every 4 weeks until disease progression. Tumor assessments will be performed every 8 weeks from the ...

In 2019, Import of Hydrazine and Hydroxylamine and Their Inorganic Salts to France was 5553560 Euros. Discover more data with NationMaster!

This report is a comprehensive research of hydrazine and hydroxylamine market in China. The report starts with giving brief country profile for China,

0007] Meanwhile, PCT/US/2010-035792 discloses formation of a thin film through heat treatment of ink including CZTS/Se nanoparticles on a base. With regard to methods of forming CZTS precursor particles, Journal, J. Am. Chem. Soc., 2009, 131, 11672 discloses that CZTS nanoparticles are formed by mixing a solution including Cu, Sn and Zn precursors and a solution including S or Se at high temperature through hot injection. In addition, US2011-0097496 discloses a method of forming a CZTS layer using a precursor for forming the CZTS layer, prepared by dissolving Cu, Zn, Sn salts together with an excess of S or Se in hydrazine, through heat treatment and selenization in subsequent processes. However, hot injection has a problem regarding stability. In addition, hydrazine including a chalcogen compound containing an excess of S or Se is a highly toxic, highly reactive, highly explosive solvent and thus a solution process using hydrazine entails high risk. Furthermore, hydrazine is difficult to handle ...

90387-38-5 - Formaldehyde, reaction products with hydrazine - Searchable synonyms, formulas, resource links, and other chemical information.