BiDil or a combination of isosorbide dinitrate and hydralazine hydrochloride was studied in two placebo-controlled clinical trials in 1,692 patients with mild to severe heart failure (mostly NYHA class II and III) and one active control trial (vs. enalapril) in 804 patients. In the multicenter trial V-HeFT I, the combination of hydralazine and isosorbide dinitrate 75 mg/40 mg qid (n=186) was compared to placebo (n=273) in men with impaired cardiac function and reduced exercise tolerance (primarily NYHA class II and III), and on therapy with digitalis glycosides and diuretics. There was no overall significant difference in mortality between the two treatment groups. There was, however, a trend favoring hydralazine and isosorbide dinitrate, which on retrospective analysis, was attributable to an effect in blacks (n=128). Survival in white patients (n=324) was similar on placebo and the combination treatment. In a second study of mortality, V-HeFT II, the combination of hydralazine and isosorbide ...

Objective: To compare the efficacy and safety of intravenous dihydralazine with ketanserin in the management of severe hypertension in the third trimester. Study design: A double blind randomised controlled trial, comparing 5 mg dihydralazine with 10 mg ketanserin after an intravenous infusion of 500 ml of a crystalloid solution. Medication was repeated every 20 min till the therapeutic goal of 90 mm Hg was reached, to a maximum of 4 dosages. Main outcome measures were treatment failures and emergency deliveries for fetal distress. Results: The therapeutic goal was met more often in patients receiving dihydralazine (36/38 compared to 27/42; P,0.01). The need for delivery for fetal distress did not differ (3 after dihydralazine, 1 after ketanserin, P=0.29). No therapy related perinatal loss occurred, but one mother with an undiagnosed phaechromocytoma died 24 h after receiving dihydralazine. Conclusion: Ketanserin in this dosage is less effective to lower diastolic blood pressure. The place of a ...

Public Health: On Race-Based Therapeutics http://scienceweek.com/2004/sc041210-5.htm The following points are made by M. Gregg Bloche (New Engl. J. Med. 2004 351:2035): 1) Are we moving into a new era of race-based therapeutics? The recent publication of the African-American Heart Failure Trial (A-HeFT), a clinical trial of a medication intended for a single racial group, poses this awkward question. The studys most striking finding -- that the addition of isosorbide dinitrate and hydralazine to conventional therapy for heart failure reduced relative one-year mortality by 43 percent among blacks -- has provoked wide discussion. The trials sponsor, NitroMed, which holds a patent on the fixed-dose combination of isosorbide dinitrate and hydralazine that was used, posits that heart failure has a different pathophysiology in blacks than in whites, necessitating different treatment strategies.(1) 2) The reported 43 percent relative decrease in the rate of death due to heart failure among blacks is ...

Data suggest that the addition of hydralazine and isosorbide dinitrate to the therapeutic regimen of digoxin and diuretics in patients with chronic congestive heart failure can have a favorable effect on left ventricular function and mortality. (From Abstract). ...

Physician reviewed hydralazine/hydrochlorothiazide/reserpine patient information - includes hydralazine/hydrochlorothiazide/reserpine description, dosage and directions.

In a double-blind, randomized crossover study, the daily administration of 30 to 90 mg of nifedipine lowered blood pressure in a dose-related fashion in 14 patients already taking a beta receptor blocker and diuretic. The duration of the hypotensive response to 20 mg of nifedipine in capsule form, giving as a step-three drug to five of these patients, was six to eight hours. A survey of 122 patients with resistant hypertension treated long-term with nifedipine and a control group of 102 similar patients treated with hydralazine revealed that nifedipine at an average dose of 40 mg daily caused a fall in blood pressure similar to that achieved with hydralazine in a dose of 86 mg daily. The side effect profile of both drugs was also similar. Nifedipine may be a useful alternative to existing step-three antihypertensive drugs.

You may be able to find Medicare plan options in your area that cover Hydralazine, Dralzine or Apresoline. Learn more about Hydralazine and find Medicare Advantage plans in your area that cover other prescription drugs.

Drug information on BiDil (hydralazine and isosorbide dinitrate), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.

Advice and warnings for the use of Hydralazine / isosorbide dinitrate (BiDil) during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out

BIDIL (Isosorbide dinitrate,Hydralazine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.

Spontaneously hypertensive rats (SHR) demonstrate an elevated minimal coronary vascular resistance by the seventh month of age. In an attempt to determine the role of long-standing hypertension in the etiological process of the elevated minimal coronary vascular resistance, we treated SHR and normotensive Wistar-Kyoto rats (WKY) with the vasodilator hydralazine from the time of weaning (1 month) until they were 7 to 8 months of age. The animals were instrumented 24 hours after their last drug dose and then studied on the following day. Using microspheres we measured myocardial perfusion in conscious rats at rest and during maximal coronary dilation induced with dipyridamole infusion. Hydralazine maintained arterial blood pressures in the normotensive range throughout the experimental period, but had little effect on left ventricular weight/body weight ratios (control SHR = 2.95 +/- 0.07, treated SHR = 2.73 +/- 0.08, control WKY = 2.39 +/- 0.09, mean +/- SEM). In treated SHR, left ventricular ...

Hypertensive crisis (defined as a systolic pressure , 160mmHg or a diastolic pressure , 110mmHg) in patients with a hypertensive disorder of pregnancy is a serious complication with severe and even deadly consequences. The management in this population had been studied, but no consensus has been reached with regards to which treatment is better. Our study will compare two drugs: Hydralazine and Labetalol for the management of hypertensive crisis ...

Hypertensive crisis (defined as a systolic pressure , 160mmHg or a diastolic pressure , 110mmHg) in patients with a hypertensive disorder of pregnancy is a serious complication with severe and even deadly consequences. The management in this population had been studied, but no consensus has been reached with regards to which treatment is better. Our study will compare two drugs: Hydralazine and Labetalol for the management of hypertensive crisis ...

The antihypertensive efficacy and safety of IV labetalol were evaluated and compared with the efficacy and safety of IV hydralazine in the treatment of postoperative hypertension. Twenty patients undergoing major noncardiac surgery were entered into

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Apresazide (Hydralazine and Hydrochlorothiazide) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...

Carbetazine 40mg/25mg - 10 Tablets Tablet (Hydralazine) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is manufactured by Nicholas Piramal India Ltd.

Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter Activity. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Our main finding is that Ang II infusion causes an upregulation of cardiac IGF-I mRNA levels in the rat. Our prior data showed that Ang II stimulates IGF-I transcription in extrahepatic tissues, including vascular smooth muscle.26 27 However, Ang II is not the prime mediator of the increase in IGF-I mRNA in vivo, because the increase was inhibited when blood pressure was normalized with the vasodilator hydralazine. This apparent hemodynamic response corresponds well with data obtained with the use of other models of pressure and volume overload1 2 3 in which an induction of IGF-I mRNA was related to increased blood pressure. Those studies included models of high as well as low renin-hypertension. However, none provided evidence that the induction was hemodynamic rather than Ang II-mediated, because hemodynamic overload could induce Ang II expression locally,28 which in turn could induce IGF-I in an autocrine fashion. The present study shows that increased Ang II levels in the absence of an ...

Background Controversial effects of L-arginine-NO pathway have been shown on renal disease. The present study analyzes the main downstream of L-arginine-NO pathway, the NO-cGMP signaling in and the effect of the specific sGC stimulator Bay 41-2272 on the injury, matrix expansion and progression phases in the rat model of anti-thy1-induced renal disease. Methods The injection of anti-thy1 antibody into rats with two kidneys or nephrectomized rats caused a sequence of the injury, matrix expansion and progression phases. The effects of Bay 41-2272 (10 mg/kg body weight/d) treatment on systolic blood pressure, proteinuria, kidney function, glomerular and tubulointerstitial matrix protein accumulation, expression of TGF- beta1, fibronectin and PAI-1, macrophage infiltration, alpha1sGC and beta1sGC mRNA expression and basal and NO-stimulated renal cGMP production were determined. In the chronic anti-thy1 model, the effect of Bay 41-2272 was compared side-by-side to the sole vasodilator hydralazine (15 ...

Get journal reprints and request samples of BiDil (isosorbide dinitrate/hydralazine). See important safety info & prescribing info.

Thank you for your interest in spreading the word on Circulation.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...

Severe hypertension during pregnancy is a relevant health problem, particularly in developing countries. The review by Duley and Henderson-Smart compared different antihypertensive drugs with the aim of identifying those with the greatest comparative benefit and least risk for adverse outcomes. Strengths of the review include a clear statement of the objective and a comprehensive literature search without language restrictions. A limitation is data heterogeneity. Contributing factors to the data heterogeneity include different criteria for severe hypertension, doses, diagnoses, and outcome definitions. Hydralazine has been the first-line drug for decades and based on this systematic review, it will continue to be. Diazoxide causes a rapid decrease in blood pressure, and as expected, this systematic review shows some probable consequences, such as an increased number of maternal hypotension episodes and the need for cesarean section due to fetal distress. Although the initial use of hydralazine ...

Hydralazine, or 1-hydrazinylphthalazine, is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator, primarily in arteries and arterioles. Upon condensing with carbonyl compounds hydralazine will form hydrazones, namely 1-phthalazinyl hydrazones, which find use as vasodilating antihypertensive drugs and also application in optoelectronics (Caruso et al., 2005).. The title compound is one such 1-phthalazinyl hydrazone. It crystallizes in the triclinic, P1, space group. The molecule exists in its E configuration with respect to the C7=N1 bond which is confirmed by the torsion angle of 177.11 (12)° of the C6-C7-N1-N2 moiety (Fig. 1). The torsion angle of -5.33 (17)° of the N1-N2-C8-N3 moiety shows that the N1 and N3 atoms are cis to each other. The C7=N1 [1.2859 (16) Å] and C8=N2 [1.3010 (16) Å] bond distances are very close to the formal C=N bond length of reported similar compounds [C=N; 1.282 (4) and 1.288 (3) Å, respectively] (e.g., Shafiq et al., ...

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.. You may need to be on a special diet while taking this medicine. Ask your doctor.. Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care ...

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.. You may need to be on a special diet while taking this medicine. Ask your doctor.. Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care ...

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.. You may need to be on a special diet while taking this medicine. Ask your doctor.. Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.. This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care ...

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...

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BiDil, a combination of isosorbide dinitrate and hydralazine, was approved by the FDA in 2005 to treat heart failure in African Americans- the first race-based indication in the U.S. Though some groups lauded this move as a win for the underserved Black community, controversy soon emerged- and rightly so. Why did the researchers come to the conclusion that this combination of drugs worked better for one racial group than another? Why did the FDA take the action to approve it this way? The answers were not reassuring.. Did you know that there is no genetic basis for discrete racial categories? If not, this is likely because of what you were taught in training. Its time to unlearn some falsehoods! The concept of race is not, in fact, biological, but social. It is not race, but racism that creates and perpetuates inequities.. Race-based medicine is bad medicine. Period. Dorothy Roberts gave a seminal TED talk in 2015 explaining this concept. The persistent myths that characteristics like pain ...

Abstract Background and Methods. To define better the efficacy of vasodilator therapy in the treatment of chronic congestive heart failure, we compared

Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...

Description of disease Race-based drug. Treatment Race-based drug. Symptoms and causes Race-based drug Prophylaxis Race-based drug

TY - JOUR. T1 - Doxazosin for the treatment of chronic congestive heart failure. T2 - Results of a randomized double-blind and placebo-controlled study. AU - DiBianco, Robert. AU - Parker, John O.. AU - Chakko, Simon. AU - Tanser, Paul H.. AU - Emmanuel, George. AU - Singh, Jang B.. AU - Marlon, Anthony. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In this study we evaluated the effects of once-daily administration of oral doxazosin in patients with chronic congestive heart failure (CHF). After a stabilization period of at least 2 weeks with digitalis and diuretics, 73 patients with chronic CHF were randomized to receive additionally either doxazosin or placebo in double-blind fashion. Patients underwent weekly dose adjustments with increasing doses of doxazosin (1, 2, 4, 8, and 16 mg daily) or placebo for 5 weeks, and 67 were evaluated for 12 additional weeks on maximally tolerated doses of blinded study drugs. Treatment groups were evaluated with respect to symptoms of heart failure, indexes of quality ...

How pretreatment with nifedipine improves the outlook for years after surgical intervention is unclear. The presumption is that this is somehow due to the consequences of afterload reduction. While the systolic blood pressures were elevated, there was no difference between the groups. Chronic afterload reduction with hydralazine, angiotensin-converting enzyme inhibitors, or other calcium channel blockers have been shown to reduce LV sizes and improve the EF, though short-term studies have not shown that hypertrophy is prevented (10).. In particular, why did nifedipine have a protective effect long after AVR? One can hallucinate a variety of thoughts, but none have much validity. Does the afterload reduction prevent irreversible changes in myocyte geometry or in the extracellular matrix (11) that recovers after AVR? Or could there be something unique about the use of a calcium blocker? For instance, it is known that myocardial blood flow is altered in AI and improved after aortic valve ...

1.Congestive Heart Failure Madi Capoccia DO 5 Jun 2007 Dewitt Army Hospital. What is CHF? Definition. advanced HF and a fixed dose of isosorbide dinitrate and ...

The treatment of heart failure in dogs involves finding the underlying cause and eliminating it.. If the heart failure is due to heartworms, bacterial infections or curable congenital heart disease, they can be treated before irreparable damage is done to the heart.. When a dog is under treatment for congestive heart failure, he will also be on a low salt diet; his exercise routine will be restricted and medication will have to be administered regularly.. The medication treatment includes calcium channel blockers, beta-blockers, digitalis glycosides and anti-arrhythmics.. In valvular heart disease or cardiomyopathy angiotensin-converting enzyme inhibitors (ACE inhibitors) are used to prolong the life of the dog.. Cardiac arrhythmias are controlled with drugs like digitalis, lidocaine, diltiazem, atropine, propranolol. Arrhythmia can also be kept under control by implanting a pacemaker.. Diuretics manage the fluid accumulations. These might be associated with potassium supplements.. Coenzyme Q, B ...

Looking for isosorbide dinitrate? Find out information about isosorbide dinitrate. C8H8N4 An antihypertensive drug; used as the hydrochloride salt Explanation of isosorbide dinitrate

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Although the hemodynamic effects of hydralazine, enalapril, and nitroglycerin have been studied extensively in both animal and human experiments, to the best of our knowledge the effects of these drugs on the splanchnic capacitance vessels in the setting of acute heart failure have not been studied previously. Our results indicate that all three vasodilator agents produced favorable hemodynamic changes. However, there were important differences between drugs in terms of their effects on the splanchnic capacitance vessels. Nitroglycerin had the greatest effect, increasing SVV7 by 32% (P,.0001), and hydralazine had the least effect, increasing SVV7 by only 3% (P=NS). The effect of enalaprilat was intermediate; it increased SVV7 by 14% (P,.001). The second most important finding of our investigations was the close relation between the degree of splanchnic venodilation and the reduction in LVEDP. Nitroglycerin, which had the greatest splanchnic venodilatory effect, also had the greatest effect on ...

Nearly 75% of patients receiving procainamide therapy will develop a positive ANA test within the first year of treatment, and over 90% develop a positive ANA

Before taking Avandia, tell your doctor or pharmacist if you have any medical conditions, especially if you have allergies to medicines, foods, or other substances, if you have experienced liver problems, including yellowing of the skin, with troglitazone, if you have a history of heart disease (e.g., chronic congestive heart failure), if you are planning to become pregnant or are breast feeding. If you become pregnant, discuss the benefits and risks of using Avandia during pregnancy with your doctor. Do not breast feed while taking Avandia. Some medicines may interact with Avandia. Therefore tell your doctor of all prescription or nonprescription medicine, herbal preparation, or dietary supplement that you are taking ...

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Key clinical point: In a survey of completed heart failure trials registered on clinicaltrials.gov, a large proportion did not report findings.Major finding: Despite a rule to report findings within 1 year of completion, only 20% of the trials met this goal.Data source: Cross-sectional analysis.Disclosures: The first and senior authors are among those who report financial relationships with pharmaceutical companies.

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The ANA test has a specificity of around 95 percent, meaning that of 20 people who test negative, 19 actually do not have lupus, but one has tested falsely negative and may have lupus. Its sensitivity is even less, meaning that more than one person out of 20 will test falsely positive but will not have lupus. False positive ANAs are fairly common and occur more frequently in older people, people with other autoimmune diseases, with viral infections, some chronic inflammations, and after taking some medications. Medications notorious for producing positive ANA tests are procainamide, used for some heart arrhythmias, and hydralazine, which used to be frequently prescribed to treat high blood pressure. Positive ANAs may persist for years after someone has taken these drugs.. The other common belief which I want to debunk here is that it is always important, even critical, to treat a disease early in the hopes of producing a cure. This belief probably stems from the emphasis we place on detecting ...

Isosorbide dinitrate information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.

Answers from trusted physicians on drugs that can cause lupus. First: The classic drugs are medications that are used for treatment of things like heart probelms (procanamide), blood pressure (hydralazine), seizures (dilantin), etc, but not everyone who uses these drugs get drug induced lupus. Recently some of the biologic drugs that are used to treat rheumatoid arthritis can cause a lupus liek syndrome. Usually stop the drug and the drug induced lupus resolves.

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Isosorbide Dinitrate-ன் பயன்பாடுகள், மருந்தளவு, பக்க விளைவுகள், நன்மைகள், தொடர்புகள் மற்றும் எச்சரிக்கைகள் ஆகியவற்றை கண்டுபிடியுங்கள்.

The number of patients with heart failure with preserved ejection fraction is on the rise, and the search is on for a therapy that can improve health outcomes in this group of patients for whom no approved therapies are available. ...

A new study suggests Americans with heart failure may benefit less from recommended medications than patients in other countries.

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BioCardia®, Inc. [OTC:BCDA], a leader in the development of comprehensive solutions for cardiovascular regenerative therapies, today announced the ini

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Equistro Haemolytan 400 er et jerntilskud til hest. Equistro Haemolytan 400 er ideelt til heste i hård trænning og heste med jernmangel

Streamliner-bilarna från Playsam fick priset Utmärkt Svensk Form med hedersomnämnande 1984. Streamliner klassiker blev vald till Svensk Designklassiker av Nationalmuseum 1998. Dessa charmiga och roliga leksaker/ prydnader är tillverkade av trä. Bilarna är designade i härliga former och lackerade med högblank färg. Lockande för såväl barn som vuxna.Denna silvriga modell är utrustad med fräck vinge samt löstagbar förare och medpassagerare. Din Playsam-bil levereras i exklusiv presentförpackning helt utan extra kostnad.

SeilNorge er landets ledende arrangør av inspirerende seilkurs, seilturer og ekspedisjoner. Vi seiler fra øy til fjell for å oppleve, se og lære. Vi leker oss i vinden, i vannet, på fjorden, i skjærgården, og i høyden i fjellene. Vi kombinerer seiling med fjell- og toppturer, kajakkpadling, fiske, musikk, mat, festivaler, skikjøring, brevandring og mye mer!

SeilNorge er landets ledende arrangør av inspirerende seilkurs, seilturer og ekspedisjoner. Vi seiler fra øy til fjell for å oppleve, se og lære. Vi leker oss i vinden, i vannet, på fjorden, i skjærgården, og i høyden i fjellene. Vi kombinerer seiling med fjell- og toppturer, kajakkpadling, fiske, musikk, mat, festivaler, skikjøring, brevandring og mye mer!

HURTIG LEVERING & GRATIS RETURNERING ➤ Stort udvalg i høj kvalitet ✔ Køb i:SY DrivE S8 ZR 20 online ✔ Velkommen på Bikester.dk

So me and DH had sex this morning - at 40+5 that was an elegant event I can tell you. Anyway, afterwards when I went to the loo I am pretty sure I h