Definition : Serology reagents intended to detect and/or identify antigens or serum antibody titers to human T-cell lymphotropic virus (also called human T-cell leukemia/lymphoma virus) type II (HTLV-II). HTLV-II retrovirus is a tumor-producing RNA virus of the subfamily Oncovirinae that may cause leukemia and other hematological diseases. Tests using these reagents are not widely utilized; these reagents may have questionable clinical usefulness, and easier or less expensive tests may be available.. Entry Terms : "Human T-Cell Leukemia/Lymphoma Virus Determination Reagents" , "HTLV-II Determination Reagents" , "Reagents, Serology, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-II". UMDC code : 19435 ...
1. Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983;220:868-871 2. Wattel E, Vartanian JP, Pannetier C, Wain-Hobson S. Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy. J Virol. 1995;69:2863-2868 3. Gessain A, Gallo RC, Franchini G. Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. J Virol. 1992;66:2288-2295 4. Wain-Hobson S. Running the gamut of retroviral variation. Trends Microbiol. 1996;4:135-141 5. Komurian F, Pelloquin F, de The G. In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies. J Virol. ...
TY - JOUR. T1 - Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. AU - Liang, Min Hui. AU - Geisbert, Thomas. AU - Yao, Yao. AU - Hinrichs, Steven H.. AU - Giam, Chou Zen. PY - 2002. Y1 - 2002. N2 - Human T-lymphotropic virus type 1 (HTLV-1) Tax exerts pleiotropic effects on multiple cellular regulatory processes to bring about NF-κB activation, aberrant cell cycle progression, and cell transformation. Here we report that Tax stimulates cellular G1/S entry but blocks mitosis. Tax expression in naive cells transduced with a retroviral vector, pBabe-Tax, leads to a significant increase in the number of cells in the S phase, with an accompanying rise in the population of cells with a DNA content of 4N or more. In all cell types tested, including BHK-21, mouse NIH 3T3, and human diploid fibroblast WI-38, Tax causes an uncoupling of DNA synthesis from cell division, resulting in the formation of multinucleated giant cells and cells with decondensed, highly ...
This confirmatory assay should be ordered only on specimens that are consistently reactive by an anti-HTLV-I/-II screening immunoassay.. For an evaluation that includes screening and confirmation, order HTLVI / Human T-Cell Lymphotropic Virus Types I and II (HTLV-I/-II) Antibody Screen with Confirmation, Serum.. ...
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and tropical spastic paraparesis. HTLV-1 encodes transactivator protein Tax that interacts with various cellular factors to modulate transcription and other biological functions. Additional cellular mediators of Tax-mediated transcriptional activation of HTLV-1 long terminal repeats (LTR) remain to be identified and characterized. In this study, we investigated the regulatory role of group I p21-activated kinases (Paks) in Tax-induced LTR activation. Both wild-type and kinase-dead mutants of Pak3 were capable of potentiating the activity of Tax to activate LTR transcription. The effect of Paks on the LTR was attributed to the N-terminal regulatory domain and required the action of CREB, CREB-regulating transcriptional coactivators (CRTCs) and p300/CREB-binding protein. Paks physically associated with Tax and CRTCs. Paks were recruited to the LTR in the presence of Tax. siRNAs against either Pak1 or Pak3 prevented
Semantic Scholar extracted view of Primary pulmonary hypertension in association with human T-cell lymphotropic virus type I in a hemophiliac. by Toru Suzuki
The human T-lymphotropic virus type I (HTLV-I) is a retrovirus that infects 10 to 20 million people worldwide, as estimated by seroprevalence studies. However, HTLV-I is associated with disease in only approximately 5 percent of infected individuals.
While human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia, a close relative, HTLV-2, is not associated with any leukemia. HTLV-1 and HTLV-2 encode the Tax1 and
Infection of human cells by human T cell leukemia virus type 1 (HTLV-1) is mediated by the viral envelope glycoproteins. The gp46 surface glycoprotein binds to cell surface receptors, including heparan sulfate proteoglycans, neuropilin 1, and glucose transporter 1, allowing the transmembrane glycoprotein to initiate fusion of the viral and cellular membranes. The envelope glycoproteins are recognized by neutralizing Abs and CTL following a protective immune response, and therefore, represent attractive components for a HTLV-1 vaccine. To begin to explore the immunological properties of potential envelope-based subunit vaccine candidates, we have used a soluble recombinant surface glycoprotein (gp46, SU) fused to the Fc region of human IgG (sRgp46-Fc) as an immunogen to vaccinate mice. The recombinant SU protein is highly immunogenic and induces high titer Ab responses, facilitating selection of hybridomas that secrete mAbs targeting SU. Many of these mAbs recognize envelope displayed on the ...
Infection with human herpesvirus 6 (HHV-6) was found to up-regulate expression of human immuno-deficiency virus and human T cell leukaemia virus type I (HTLV-I) long terminal repeat sequence (LTR), and herpes simplex virus type 1 (HSV-1) gD chloramphenicol acetyltransferase (CAT) constructs transfected into the T cell line, J. Jhan. Activation by HHV-6 was due to one or more viral proteins produced early in infection and, in the case of the HTLV-I LTR, was synergistic to induction mediated by the HTLV-I tax gene product. Neither the HTLV-I enhancer nor basal promoter elements of the HSV-1 gD gene were essential for activation and no increase in accumulated HTLV-I mRNA was observed due to HHV-6 infection. Induction by HHV-6 was found to be dependent on the reporter construct used, because the CAT gene and, to a lesser extent, the HSV-1 thymidine kinase gene were responsive to HHV-6 infection although no significant activation of growth hormone constructs was observed. Our results bear a strong
Objectives : Although human T-cell lymphotropic virus type 1 HTLV-1 - associated uveitis has been well recognized in Japan, related studies in Brazil are scarce. We performed a serologic survey for HTLV-infection among patients with uveitis and investigated the ocular findings in HTLV-1-asymptomatic carriers. Methods : One hundred ninety serum...
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Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a variety of immunoregulatory disorders. HTLV-1 has been shown to bind to and infect a variety of hematopoietic and nonhematopoietic cells. However, both in vivo and in vitro, the provirus is mostly detected in and preferentially transforms CD4+ T cells. The molecular mechanism that determines the CD4+ T-cell tropism of HTLV-1 has not been determined. Using cocultures of purified CD4+ and CD8+ T cells with an HTLV-1 producing cell line, we measured viral transcription by using Northern (RNA) blot analysis, protein production by using a p24 antigen capture assay and flow cytometric analysis for viral envelope, and proviral integration by using DNA slot blot analysis. We further measured HTLV-1 long terminal repeat-directed transcription in purified CD4+ and CD8+ T cells by using transient transfection assays and in vitro transcription. We demonstrate a higher rate of viral ...
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The individual T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IB kinases (IKKs) and NF-B and promote cell survival; nevertheless, the essential ubiquitinated elements downstream of Taxes included in cell alteration are unidentified. of HTLV-1 changed cells and the immortalization of principal Testosterone levels cells by HTLV-1. As a result, T63-connected polyubiquitination represents a story regulatory system managing MCL-1 balance that provides been usurped by a virus-like oncogene to precipitate cell success and alteration. Writer Overview HTLV-1 infections is certainly etiologically connected to the advancement of the neuroinflammatory disorder HTLV-1 linked myelopathy/exotic spastic paraparesis (Pig/TSP) and adult T-cell leukemia (ATL), an intense Compact disc4+Compact disc25+ malignancy. The HTLV-1 regulatory proteins Taxes constitutively activates the IB kinases (IKKs) and NF-B to promote cell success, transformation and proliferation. ...
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Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells. ...
in Oncogene (2011). Human T cell leukemia virus type-1 (HTLV-1) is the causative agent of a fatal adult T-cell leukemia. Through deregulation of multiple cellular signaling pathways the viral Tax protein has a pivotal role ... [more ▼]. Human T cell leukemia virus type-1 (HTLV-1) is the causative agent of a fatal adult T-cell leukemia. Through deregulation of multiple cellular signaling pathways the viral Tax protein has a pivotal role in T-cell transformation. In response to stressful stimuli, cells mount a cellular stress response to limit the damage that environmental forces inflict on DNA or proteins. During stress response, cells postpone the translation of most cellular mRNAs, which are gathered into cytoplasmic mRNA-silencing foci called stress granules (SGs) and allocate their available resources towards the production of dedicated stress-management proteins. Here we demonstrate that Tax controls the formation of SGs and interferes with the cellular stress response pathway. In ...
Psychological and medical predictors of disease course in breast cancer: a prospective study (pages 383-400). Shulmaith Kreitler, Hans Kreitler, Samario Chaitchik, Shlomo Shaked and Tal Shaked. Version of Record online: 4 DEC 1998 , DOI: 10.1002/(SICI)1099-0984(199712)11:5,383::AID-PER300,3.0.CO;2-#. ...
Human T-lymphotropic virus 1 p21X protein: the complete amino acid sequence of p21X is contained within the C-terminal portion of p27rex
Information about Human T-Cell Lymphotropic Virus (HTLV) I/II Antibody Confirmation. Search our extensive database of medical/laboratory tests and review in-depth information about each test.
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HTLV-2 RNA in PBMCs and cell subsets.HTLV-2 taxRNA was revealed in the PBMCs of 7 of the 12 patients without PSP (58.3%) and in those of 4 of the 6 patients with PSP (66.7%). All but one of the patients with proviral loads of ,0.01 PU/103were negative for HTLV RNA.. The median titer of HTLV-2 RNA in PBMCs was lower than that of HTLV-2 DNA (median titer, 0.01 PU/103 cells; range, 0 to 1 PU/103 cells). No significant correlation between HTLV-2 DNA and RNA titers was observed. No difference was found between the RNA titers of the subjects with and without PSP.. Reverse transcription-PCR could also be performed on the CD14+ and CD19+ cells of two patients each (patients 1 and 3 and patients 8 and 11, respectively) and on the CD3+ cells of six patients (patients 1, 2, 3, 7, 8, and 11). All the CD14+ cell samples, one CD19+ cell sample, and three of the six CD3+ cell samples showed HTLV-2 tax RNA sequences.. The titers of tax RNA in the CD14+ cells of patient 1 (3.7 PU/103 cells) and the CD19+cells of ...
Here, we report a novel interaction between the scaffolding protein hDlg and the envelope glycoproteins of HTLV-1. We demonstrate that hDlg binds to the cytoplasmic domain of the HTLV-1 Env and that the two proteins are concentrated in cell contact sites at the plasma membrane of infected T-lymphocytes. We also show that preventing Env/hDlg interaction in the context of a complete HTLV-1 virus leads to decreased ability of Env to trigger cell-to-cell fusion between T lymphocytes. These findings constitute the first example of a functional interaction between a MAGUK family member and a viral structural protein.. Like other members of this subfamily of MAGUKs, hDlg is composed of protein interaction modules including three PDZ domains, a central SH3 domain, and a C-terminal GUK domain (Gonzalez-Mariscal et al., 2000). Sequence analysis showed that the four C-terminal residues of Env-CD (E-S-S-L) were conserved between the most distant HTLV-1 strains (Gessain et al., 1993; Malik et al., 1988), and ...
Retroviruses have evolved complex mechanisms to regulate their cellular tropism and gene expression. It is generally accepted that productive infections proceed via interactions between viral envelope molecules and specific receptors on the host cell surface. Currently, there is no known receptor for HTLV-1, though a number of factors that enhance entry have been identified. In an effort to identify a cellular receptor or attachment factor for HTLV-1, we carried out a retroviral cDNA library screen, in which cDNA from permissive HeLa S3 cells was introduced into poorly susceptible NIH 3T3 cells. These cells were selected after infection with HTLV-1 envelope pseudotyped viral particles expressing a drug resistance gene. We isolated approximately 460 cDNAs, of which 20 were prioritized as potential candidates. These candidates are being tested to determine if they participate in viral entry. In addition to encoding the structural and enzymatic genes common to all retroviruses, HTLV-1 also encodes several
Table 2: The prevalence of HTLV1 antibodies in studied subjects according to the age distribution of women and their gestational age ...
Interdisciplinary Perspectives on Infectious Diseases is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of infectious diseases.
A type of virus that infects T cells (a type of white blood cell) and can cause leukemia and lymphoma. Human T-cell lymphotropic virus type 1 is spread by sharing syringes or needles, through blood transfusions or sexual contact, and from mother to child during birth or breast-feeding. Also called HTLV-1 and human T-cell leukemia virus type 1 ...
Looking at socioeconomic parameters as measured by the percentage of heads of household with income below the minimum wage it was noted that the poorest sub-areas, i.e., Jequitinhonha and Mucuri, match the sub-areas with the highest HTLV-1/2 seropositivity (Figure 2). Figure 3 shows a similar geographic correlation, in which sub-areas with heads of household with formal education equal to or lesser than 1 year overlap with the ones presenting higher proportions of HTLV-1/2 seropositive mothers, again Jequitinhonha and Mucuri. DISCUSSION. To our knowledge, this is the first time that a neonatal screening program, covering all newborns in a population of almost 20 million inhabitants, was used to both identify HTLV-1/2 seropositive mothers and to intervene to reduce the risk of vertical transmission of the virus from mother to child. In 2007, the seropositivity in the HTLV-1/2 screening test (ELISA) was 8 per 10 000, for blood donors at the Hemominas Foundation, and 2 per 10 000 with a ...
Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to current available therapies and has a very poor prognosis. To prevent the development of ATL among carriers it is important to control HTLV-1-infected cells in infected individuals. Therefore, the establishment of novel therapies with drugs specifically targeting infected cells is urgently required. This study aimed to develop a potential therapy by generating recombinant vesicular stomatitis viruses (rVSVs) that lack an envelope glycoprotein G and instead encode HTLV-1 receptor(s) with human glucose transporter 1 (GLUT1), neuropilin 1 (NRP1), or heparan sulfate proteoglycans (HSPGs) including syndecan 1 (SDC1), designated as VSVΔG-GL, VSVΔG-NP, or VSVΔG-SD, respectively ...
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1. Gingerich O (2006). Gods Universe. (Cambridge MA: Harvard University Press), p.72 2. Wolpert L (2006). Six Impossible Things Before Breakfast. (London: Farber and Farber), p.214 3. Karpas A (2005). Human retroviruses in leukaemia and AIDS: reflections on their discovery, biology and epidemiology. Biol Revs Camb Philos Soc79, 911 4. Mortreux F, Gabet A-S and Wattel E (2003). Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia17, 26; Tsukasaki K, Koeffler P and Tomonaga M (2000). Human T-lymphotropic virus type I infection. Best Pract Res Clin Haematol13, 231 5. An artificial retrovirus carrying a therapeutic gene has also produced leukaemia. In each patient, one insertion event targeted and dysregulated a key (LMO2) gene. Every derived leukaemic cell possessed the same (clonal) provirus insert. See Hacein-Bey-Abina S, Von Kalle C, Schmidt M et al (2003). LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID- X1. Science302, ...
Background: Human T cell leukemia virus type 1 (HTLV-1) gene expression is controlled by the key regulatory proteins Tax and Rex. The concerted action of these proteins results in a two-phase kinetics of viral expression that depends on a time delay between their action. However, it is difficult to explain this delay, as Tax and Rex are produced from the same mRNA. In the present study we investigated whether HTLV-1 may produce novel mRNA species capable of expressing Rex and Tax independently.. Findings: Results revealed the expression of three alternatively spliced transcripts coding for novel Rex isoforms in infected cell lines and in primary samples from infected patients. One mRNA coded for a Tax isoform and a Rex isoform, and two mRNAs coded for Rex isoforms but not Tax. Functional assays showed that these Rex isoforms exhibit activity comparable to canonic Rex. An analysis of the temporal expression of these transcripts upon ex vivo culture of cells from infected patients and cell lines ...
The most recent milestones in tumor virology have come from the identification of additional human tumor viruses: human T-cell leukemia virus type 1 (HTLV-1), hepatitis C virus (HCV), and Kaposis sarcoma virus.. HTLV-1: the first tumorigenic human retrovirus. In 1977, Kiyoshi Takatsuki and colleagues discovered a variable T-cell leukemia in Japanese adults with a unique set of properties that warranted the classification of the disease as a single syndrome called adult T-cell leukemia (ATL; ref. 92). Reminiscent of Burkitts lymphoma, ATL showed a distinct geographic distribution in Japan, with most cases clustered on the southern islands of Kyushu and Okinawa and the northern island of Hokkaido and with only sporadic cases found in remote coastal villages along the largest island of Honshu. These observations suggested the possibility of an infectious etiologic agent for ATL.. In the 1970s, decades of attempts to identify a human retrovirus had failed, despite the successful isolation of many ...
T cell leukemia virus type 1 (HTLV-1) is a causative factor for adult T cell leukemia and lymphoma (ATLL). HTLV-1 genome encodes a viral transforming protein, T...
A multiplex nucleic acid assay was developed by Vet et al., 1999, that both identified and quantified the abundance of retroviruses including the HIV-1, HIV-2 and human T-lymphotropic virus type I and II. Amplification of the retroviral DNA sequences is performed through PCR assays in a spectrofluorometric thermal cycler. The amplified retroviral DNA is hybridized to specific fluorescent probes which include fluorescein for HIV-1, tetracholoro-6-carboxyfluorescein (TET) for HIV-2, tetramethylrhodamine (TMR) for HTLV-I and carboxyrhodamine (RHD) for HTLV-II. The fluorescence colour is crucial for identification of the specific retroviruses. Fluorescence spectrum at 500-650 nm is detected from the assay sample during the annealing phase of the thermal cycle. Quantification of the retro-viral DNA abundance is conducted in real-time, where the intensity of the fluorescence signal is increased significantly with the number of thermal cycles. The reliability of the assay is demonstrated with clinical ...
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Dr. Han received her MD from Harbin Medical University, China. She carried out doctoral studies on the detection of human T-cell leukemia virus type-1 in a human T-lyphoblastic lymphoma xenotransplant in nude mouse and an exploration of the mechanism of horizontal oncogenesis in the xenograft, obtaining her Ph.D. She then carried out postdoctoral studies on gene targeting at the Institute of Genetics, Chinese Academy of Sciences, followed by research on the regulation of cytosolic phospholipase A2alpha (cPLA2alpha) and cyclooxygenase-2 (COX-2)-derived prostaglandin and related signaling pathways in liver cancer at the Department of Pathology of University of Pittsburgh School of Medicine. She generated two novel transgenic mice with targeted expression of the cPLA2alpha and COX-2, respectively, in the liver and gained significant expertise in a variety of in vitro and iv vivo model systems for the study of liver cell biology and cancer. In 2005 she was promoted as an assistant professor of ...
Dr. Han received her MD from Harbin Medical University, China. She carried out doctoral studies on the detection of human T-cell leukemia virus type-1 in a human T-lyphoblastic lymphoma xenotransplant in nude mouse and an exploration of the mechanism of horizontal oncogenesis in the xenograft, obtaining her Ph.D. She then carried out postdoctoral studies on gene targeting at the Institute of Genetics, Chinese Academy of Sciences, followed by research on the regulation of cytosolic phospholipase A2alpha (cPLA2alpha) and cyclooxygenase-2 (COX-2)-derived prostaglandin and related signaling pathways in liver cancer at the Department of Pathology of University of Pittsburgh School of Medicine. She generated two novel transgenic mice with targeted expression of the cPLA2alpha and COX-2, respectively, in the liver and gained significant expertise in a variety of in vitro and iv vivo model systems for the study of liver cell biology and cancer. In 2005 she was promoted as an assistant professor of ...
Dodon MD، Hamaia S، Martin J، Gazzolo L (2002). "Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element". J. Biol. Chem. 277 (21): 18744-52. PMID 11893730. doi:10.1074/jbc.M109087200. ...
The aim of this report is to review the relationship between viruses and the development of human cancer. It is currently known at least four viruses are directly implicated in the aetiology of human cancers and are involved in the induction of 15 to 20% of the worldwide tumor burden. Infection with these viruses seems to be an essential, but not sufficient, step in the multistage proces of carcinogenesis. Other changes, induced for instance by chemical carcinogens or radiation, are also required to change the virus infected cell into a tumor cell. The four most important human tumor viruses are: human T cell leukemia viruses (HTLV); Epstein-Barr virus (EBV); hepatitis B virus (HBV) and human papillomavirus (HPV). Because of HPV is probably involved in the development of over 10% of all human tumors and hence is the most important biological agent in relation to cancer, it is discussed more extensively in this report ...
This 1362 word essay is about Lentiviruses, HIVAIDS, Animal virology, Visna virus, Human T-lymphotropic virus, Infectious causes of cancer. Read the full essay now!
TCTA - TCTA (untagged)-Human T-cell leukemia translocation altered gene (TCTA) available for purchase from OriGene - Your Gene Company.
InstituteiHumanInstituteR[email protected]shanghaitech.edu.cnBiographyDr.ZhonggotthebachelordegreeofphysicsatAnhuiUniversityat1999;gotthemasterdegreeofBiophysicsatUniversityofScienceandTechnologyofChinaat2002andreceivedhisPhDdegreeofNeurobiologyandBehavioratCornellUniversityat2007.From2007-2015,Dr.ZhongreceivedhispostdoctoraltraininginthefieldofneurobiologyandsuperresolutionfluorescenceimagingatCornellUniversityandHarvardUniversity.From2015,Dr.Zhong
Among mature postthymic T-cell leukemias, adult T-cell leukemia (ATL) has characteristic clinicopathological entities. The association with the human T-cell leukemia/lymphotropic virus type I is one of the distinctive etiopathogenetic features of this disease. However, unlike other acute transforming retroviruses, the human T-cell leukemia/lymphotropic virus type I lacks an oncogene within its genome. Other human postthymic leukemias, such as T-prolymphocytic leukemias, involve mostly the CD4 cellular subset and share many similarities to ATLs (aggressive course, cutaneous involvement, CD4+, CD29+, CD45RA- phenotype, and alphanaphthyl-acetate esterase positivity). A chromosomal rearrangement at 14q32.1, involved in translocations or inversions with either the α/δ locus [t(14;14)(q11;q32.1), inv14(q11;q32.1)], or the β-chain locus of the T-cell receptor [t(7;14)(q35;q32.1)] is found. These rearrangements disregulate a gene, TCL1, located at the 14q32.1 region, that we show is physiologically ...
We describe an immunosuppressed patient who developed myelopathy after transfusion with human T cell lymphotropic virus type 1-infected blood products during cardiac transplantation; immunoglobulins and fibrinogen deposition indicated disruption of the blood-brain barrier. The low degree of inflammation and virus expression suggests that demyelination may have been caused by an antibody- and complement-mediated process and by an alteration of the spinal cord microenvironment with activation of microglial cells and astrocytes.. ...
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell lymphoma caused by human T-cell leukemia/lymphoma virus type 1 (HTLV-1). ATLL occurs in approximately 3%-5% of HTLV-1 carriers during their lifetime and follows a heterogeneous clinical course. The Shimoyama classification has been frequently used for treatment decisions in ATLL patients, and antiviral therapy has been reportedly promising, particularly in patients with indolent type ATLL; however, the prognosis continues to be dismal for patients with aggressive-type ATLL. Recent efforts to improve treatment outcomes have been focused on the development of prognostic stratification and improved dosage, timing, and combination of therapeutic modalities, such as antiviral therapy, chemotherapy, allogeneic hematopoietic stem cell transplantation, and molecular targeted therapy.
The details of bibliography - Genotyping of Human T cell lymphotropic virus Type 1 Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: insights into viral evolution and dissemination
The details of bibliography - Genotyping of Human T cell lymphotropic virus Type 1 Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: insights into viral evolution and dissemination
An epidemiological study was performed in French Guiana population 115,000 to determine the prevalence and incidence of adult T-cell leukemia/lymphoma ATL associated with human T-cell leukemia/lymphoma virus type I HTLV-I. From January 1990 to December 1993, all suspected cases of ATL were enrolled in this study, and their clinical,...