Homocysteine Causes, Symptoms, Treatment - What are the possible symptoms and signs of elevated homocysteine levels? - eMedicineHealth: FONT SIZE AAA «Previous 1 2 3 4 5 ...Next» (Page 3 of 7)Glossary Homocysteine (cont.) View Heart Disease (Coronary Artery Disease) Slideshow Pictures A Visual Guide to Heart Disease Medical Illustrations of the Heart Image Collection Take the Heart Disease Quiz! FACEBOOK TWITTER EMAIL PRINT ARTICLE IN THIS ARTICLE What is homocysteine? Why are homocysteine levels measured? What are the possible symptoms and signs of elevated homocysteine levels? What are high homocysteine levels? What causes elevated homocysteine levels? Can elevated homocysteine levels be hereditary? How can homocysteine levels be lowered? Can lowering homocysteine levels prevent the risk of heart disease, heart attacks, and strokes? Who should have their homocysteine levels tested? Homocysteine Topic Guide What are the possible symptoms and signs of elevated homocysteine levels? Elevated ...
TY - JOUR. T1 - Increase in total plasma homocysteine concentration after cardiac transplantation. AU - Berger, P. B.. AU - Jones, J. D.. AU - Olson, L. J.. AU - Edwards, Brooks Sayre. AU - Frantz, Robert. AU - Rodeheffer, R. J.. AU - Kottke, B. A.. AU - Daly, R. C.. AU - McGregor, C. G A. PY - 1995. Y1 - 1995. N2 - Objective: To determine whether plasma homocysteine concentrations are increased in patients after cardiac transplantation. Design: Total plasma homocysteine concentration was measured in 44 consecutive patients before and at 3, 6, and 12 months after orthotopic heart transplantation between June 1, 1988, and Oct. 15, 1992, and the data were analyzed statistically. Results: Mean homocysteine concentrations (normal range, 4 to 17 μmol/L) increased 70% from 12.5 μmol/L before cardiac transplantation to 21.2 μmol/L (P,0.002) 3 months after transplantation, at which time the concentrations were above normal in 14 of 26 patients (54%). Homocysteine concentrations remained elevated 6 ...
PubMed journal article Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate statu were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
A high homocysteine concentration is a potential risk for cardiovascular disease. Plasma homocysteine concentrations can be lowered through betaine supplementation. However, effects of choline supplementation, the precursor for betaine, on plasma homocysteine concentrations in healthy humans are unknown. If supplementation with choline or phosphatidylcholine, the form in which choline occurs in foods, lowers homocysteine concentrations, then extra intake of these compounds may lower cardiovascular disease risk in humans.. Comparison: We compared the effects of supplementation with phosphatidylcholine to the effects of a placebo on fasting and post-methionine concentrations of plasma homocysteine in healthy men. ...
Objective- Dexrazoxane is an antioxidant prodrug that on hydrolysis is converted into an intracellular iron chelator. We hypothesized that the antioxidant effects of dexrazoxane would prevent homocysteine-induced endothelial dysfunction in the brachial artery of normal human subjects.. Methods and Results- Ten healthy volunteers completed a randomized, double-blind, crossover study. Plasma homocysteine levels and brachial artery endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (sublingual nitroglycerin) responses were measured before and 4 hours after ingestion of l-methionine (100 mg/kg), preceded by intravenous administration of dexrazoxane (500 mg/m2) or placebo over 30 minutes. After placebo, oral methionine increased plasma homocysteine (from 5.1±0.4 μmol/L at baseline to 14.2±1.3 μmol/L at 4 hours, P,0.001) and decreased FMD (from 3.8±0.7% at baseline to 1.2±0.5% at 4 hours, P=0.02). Dexrazoxane did not change homocysteine concentrations after ...
Received: 23 Dec, 2008 : Accepted: 8 July 2009 Abstract Background & Aims: Major depression is a mood disorder and the most common psychological disorder. As consistent findings in the major depressive disorder (MDD) denote for a low plasma folate and elevated plasma homocysteine concentration s the results of studies are controversary. In addition, there ...
Disease and Homocysteine Concentration. Dogs in the heart disease, neoplastic disease, kidney disease, and skin disease groups had significantly higher plasma Hcy concentrations than control dogs. However,multivariate logistic regression analyses adjusted for age, sex, and spay/neuter status revealed that Hcy concentration was only associated with skin disease when these other variables were included in the model. The odds ratio per 1 μmol/l increase in Hcy was 1.077, 95% confidence interval (CI) 1.001-1.158, p,0.05. In the control group (n=187), the mean plasma Hcy concentration was 13.5 ± 0.4 μmol/l (first quartile-median-third quartile 9.6-12.8-16.0, and min-max 4.3-50.1 μmol/l). In the skin disease group (n=16), the mean plasma Hcy concentration was 20.3 ± 2.3 μmol/l (first quartile-median-third quartile 13.8-19.3-23.3, and min-max 9.7-49.8 μmol/l). The skin disease group included five Shih Tzus and 11 other dogs of nine different breeds. However, our finding that Hcy ...
Normative data were obtained from the general population of the same age.. The researchers found celiac patients to have higher total plasma homocysteine levels than the general population, indicative of a poor vitamin status.. Additionally, the plasma levels of folate and pyridoxal 5-phosphate, the active form of vitamin B-6, were low in 37% and 20% of celiac patients respectively. These reduced levels accounted for 33% of the variation of the total plasma homocysteine level.. Celiac patients also had mean intakes of folate and vitamin B-12, although not of vitamin B-6, that were significantly lower than in controls.. Professor C. Hallert, one of the authors of the report, said, "Half of the adult celiac patients carefully treated with a gluten-free diet for several years showed signs of a poor vitamin status.". He added, "This may have clinical implications considering the linkage between vitamin deficiency, elevated total plasma homocysteine levels and cardiovascular disease.". "The results ...
This is the first prospective, population-based study of the role of high homocysteine levels as a risk factor for coronary heart disease and cerebrovascular disease in the elderly. The subjects mean age at baseline was 71.5 years (range, 64 to 84 years), which is substantially higher than the mean ages in previous prospective studies (46 to 60 years).4 5 6 7 8 9 Suggested cutoff values for high homocysteine levels have ranged from 11.4 to 15.8 μmol/L.2 4 5 6 7 11 16 In our study, 33% of the subjects had levels of ≥17 μmol/L. Thus, our study confirms that high homocysteine levels are extremely common among the free-living elderly.11 We found that a high serum homocysteine level was strongly associated with the baseline prevalence of myocardial infarction and stroke. During 10-year follow-up, it was associated with a modest, borderline significant increase in the risk of dying of coronary heart disease and, among normotensive subjects, with a large increase in the risk of fatal ...
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The serum concentration of the amino acid homocysteine is positively associated with the risk of ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke. 1 2 There is uncertainty over whether these associations are causal. 3 4 Resolving the question of causality is important because serum homocysteine can be lowered by the B vitamin folic acid, 5 6 raising the prospect of a simple and safe means of prevention.. Three rare autosomal recessive disorders (the homocystinurias), in which homozygotes lack one of the three principal enzymes in homocysteine metabolism, cause extremely high serum homocysteine levels (,100μmol/l) and a high risk of premature cardiovascular disease (affecting half of homozygotes by the age of 307). The biochemical change that is common to all three disorders is a high serum homocysteine concentration (no other substance is consistently high or low), 8 9 indicating that high homocysteine levels cause cardiovascular disease.. Whether moderate ...
A risk factor may show disease causation; if it suggests a plausible intervention, then it is all the more interesting. It is even better if that intervention is preventive. Robust risk factors for Alzheimer disease are now well established: increased age, the Down syndrome, poor education, and apolipoprotein E status. These risks are not easily altered. Biological risk factors that can be altered are especially attractive. Some, such as estrogen use and middle-life vascular risk-factor control, have accumulating evidence and suggest obvious, if awkward, interventions. The homocysteine story includes a plausible mechanism for causing Alzheimer disease, and the suggested intervention (dietary folate supplementation) is cheap, easy, and available to all. Folate prevents neural tube defects, a finding that has already led to dietary supplementation with folate in the United States. The study by Seshadri and colleagues is hypothesis generating and prospectively studies 1092 participants from the ...
A total of 523 subjects (297 females and 226 males) from the Canary Islands Nutrition Study (ENCA) were studied in order to examine the effect of the MTHFR 677C,T, 1298A,C and 1793G,A polymorphisms, adjusted for age, serum (5)-folate and S-cobalamin levels, on total plasma homocysteine concentrations (tHcy). Genotyping was performed with Pyrosequencing(R) technology. The MTHFR 677T-allele was associated with increased tHcy concentrations only in males (P=0.005). The MTHFR 1298C-allele was found to be associated with higher tHcy levels but similarly, only in males (P=0.025). The MTHFR 1793A-allele was associated with decreased tHcy concentrations in the younger males (P=0.042). A haplotype-based approach was marginally superior in explaining the genetic interaction of the MTHFR polymorphisms on tHcy plasma levels (R-2 0.352 vs. 0.342 for a simple genotype-based approach). A nutrigenetic interaction between the MTHFR 677C,T genotype and S-cobalamin on tHcy levels was demonstrated in both genders. ...
Elevated homocysteine levels are influenced by a number of genetic, dietary and environmental factors.. There are many nutrients which are essential for healthy methylation function, some of these include Vitamin B6, Vitamin B12 and Folic Acid.. A lack of dietary intake of any of the above nutrients will impact methylation function and consequently homocysteine levels.. One study from 2003 concluded that B-vitamin requirements necessary to maintain normal plasma homocysteine concentrations are higher in L-dopa-treated patients than in those not on L-dopa therapy. B-Vitamin supplements may be warranted for PD patients on L-dopa therapy. [9]. Leafy greens are an excellent dietary source of folate and individuals with gene mutations such as MTHFR should consume at least 1 cup daily in order to obtain enough folate.. Sardines are an excellent source of Vitamin B12 and contain many other beneficial nutrients for individuals with Parkinsons Disease such as longchain anti-inflammatory Omega-3 fatty ...
Vegetarians are known to be deficient in vitamin B12, due to a lack or absence of dietary animal produce, which can elevate homocysteine. There is strong evidence indicating that elevated plasma total homocysteine (tHcy) is a contributor to chronic conditions, such as primary cardiovascular disease (CVD). The study hypothesis is: There will be a significant decrease in plasma tHcy of vegetarians following the intervention by supplementary vitamin B12 (of the methylcobalamin type) and this will lead to a reduction of the risk of CVD ...
SafetyAlerts) - People with elevated levels of homocysteine in the blood had nearly double the risk of developing Alzheimers disease (AD), according to a new report from scientists at Boston University. The findings, in a group of people participating in the long-running Framingham Study, are the first to tie homocysteine levels measured several years before with later diagnosis of AD and other dementias. The report, which appears in the February 14, 2002, issue of The New England Journal of Medicine, provides some of the most powerful evidence yet of an association between high plasma homocysteine and later, significant memory loss. The relationship between AD and the amino acid homocysteine is of particular interest because blood levels of homocysteine can be reduced, for example, by increasing intake of folic acid (or folate) and vitamins B6 and B12. The therapeutic use of these compounds is being explored as scientists try to understand better homocysteines role in AD or other types of ...
BACKGROUND: The association between blood homocysteine concentration and the risk of cardiovascular disease (CVD) remains controversial, but few studies have examined the association between MTHFR C677T (a proxy for high homocysteine concentration) and death from CVD. OBJECTIVE: The objective was to examine associations of MTHFR C677T, a proxy for high homocysteine concentrations, with CVD mortality and with all-cause mortality in a national representative prospective cohort of the US adult population before the introduction of mandatory folic acid fortification of flour. DESIGN: We used Mendelian randomization to examine the association of MTHFR C677T with cause-specific mortality in 5925 participants by accessing the NHANES III (1991-1994) Linked Mortality File (through 2006). RESULTS: A comparison of homozygotes at baseline showed that individuals with a TT genotype had a 2.2-μmol/L higher homocysteine and a 1.4-ng/mL lower folate concentration, respectively, than did those with a CC genotype. The
In 1992, 2 rather distinct forms of hyper-homocysteinemia were hypothesized: fasting and post-methionine loading (1). Animal experiments (2), human observations (3), and recent population-based data (4) support this hypothesis. The European Concerted Action Project (COMAC) found that approximately 30% of persons with hyper-homocysteinemia had isolated post-methionine-loading hyperhomocysteinemia, with normal fasting Hcy levels providing further confirmation of this hypothesis. More important, the COMAC data suggest that isolated post-methionine-loading hyperhomocysteinemia is not a biochemical curiosity but an independent risk factor for cardiovascular disease. The COMAC data are important for testing the hypothesis that lowering Hcy levels will reduce cardiovascular disease. If all patients at risk for mild to moderate hyper-homocysteinemia are to be identified, methionine loading is indicated. A valid 2-hour methionine-loading protocol is now available (5). The COMAC project also found that ...
Question - Have high homocysteine level. Feeling tired. Which amount of folic acid is required?. Ask a Doctor about uses, dosages and side-effects of Testosterone, Ask a General & Family Physician
Weve recently uncovered the mthfr mutation in my family. My daughter is homozygous c677t. Two weeks ago her homocysteine level was 17 and yesterday we received results of a test that said she was 8.8? I read the article above, she did not eat anything before both tests but she did have a coffee before test resulting in level of 17 is the coffee enough to cause such a variance? Shes been referred to a cardiologist based on symptoms and homocysteine level of 17. Should I disregard results and start over this is all overwhelming. Shes had health issues for 12 years and shes only 24. Shes been diagnosed with Polycystic ovary syndrome, subclinical hypothyroidism , chest wall syndrome. She gets strep throat 2 to 3 times a year shes had mono three times. She went to Peru for two weeks and came home so sick at the age of 17 that it took months to get back on her feet. Weve been trying to find the root issue for a long long time. She constantly has pain in chest, her joints give her issues ...
Weve recently uncovered the mthfr mutation in my family. My daughter is homozygous c677t. Two weeks ago her homocysteine level was 17 and yesterday we received results of a test that said she was 8.8? I read the article above, she did not eat anything before both tests but she did have a coffee before test resulting in level of 17 is the coffee enough to cause such a variance? Shes been referred to a cardiologist based on symptoms and homocysteine level of 17. Should I disregard results and start over this is all overwhelming. Shes had health issues for 12 years and shes only 24. Shes been diagnosed with Polycystic ovary syndrome, subclinical hypothyroidism , chest wall syndrome. She gets strep throat 2 to 3 times a year shes had mono three times. She went to Peru for two weeks and came home so sick at the age of 17 that it took months to get back on her feet. Weve been trying to find the root issue for a long long time. She constantly has pain in chest, her joints give her issues ...
Coronary artery disease (CAD) is the major cause of death in both sexes in the western world. In men with chest pain the diagnostic methods are more useful than in women. An exercise test is considered less reliable in women, mostly due to a high percentage offalse positive tests. Furthermore, 20-40% of women with typical angina have normal vessels at coronary angiography. The mechanisms behind the chest pain in these patients are unknown, but could be due to disturbances in endothelial, thrombogenetic and/or fibrinolytic function.. In a prospective multicentre trial we examined 200 postmenopausal women with unstable CAD and 101 healthy controls. At coronary angiography 15% had normal vessels, 14% had non-significant atherosclerosis and 71% had at least one significant stenosis.. The diagnostic information from basic clinical parameters, ECG and an early exercise test were evaluated. The prevalence of coronary atherosclerosis was high, 85%, and the early exercise test was just as valuable as in ...
Background: In the past 37 years, increased efforts have been directed toward a better understanding of the importance of Hcy in disease and it has now become clear that hyperhomocysteinemia is a major independent risk factor for CVD. Extensive research on the influence of vitamin supplementation leading to reductions in Hcy levels and improvements in cardiovascular function has been done. The importance of exercise in the lowering of cardiovascular risk factors, as well as its favourable influence on cardiovascular function has also been indicated in several studies, however, the limited number of studies investigating the effect of exercise on Hcy concentrations revealed contradicting results. Furthermore, a relationship between Hcy concentration and cardiovascular function with the intervention of an exercise training and a vitamin supplementation programme respectively has also not been investigated. Objective: The objective of this study was to examine the effect of a 12-week exercise ...
Slightly or even moderately increased levels of plasma homocysteine, as seen in patients with heterozygous cystathione deficiency, do not seem to indicate an increased risk of coronary artery disease (CAD). The homozygous form of this condition, associated with greater than 100-fold levels of plasma homocysteine, often indicates severe peripheral vascular disease, but patients have an incidence of CAD equal to that in an otherwise healthy population. Many observational studies, however, have found a significant association between elevated homocysteine levels and CAD. However, persons with elevated homocysteine levels may have less healthy lifestyles, which is itself a risk factor for CAD. Cleophas and associates performed a meta-analysis of case-control and cohort studies examining the relationship between homocysteine level and CAD risk.. Thirty-three studies were uncovered in a search of the literature (22 case-control and 11 cohort studies), involving a total of more than 16,000 patients. ...
Elevated homocysteine levels have been linked from everything from cancer to diabetes to autoimmune disorders to stroke (however, please note that these results are far from unanimous, there are a number of studies showing the contrary for each of the diseases listed. Furthermore, there is still some debate as to whether the high levels of homocysteine are a causal factor for these disorders or just another side effect or symptom of these disorders. Nevertheless, the near-ubiquitous presence of high homocysteine levels in so many diseases across the board should at least suggest that homocysteine-lowering efforts are of great potential benefit, at least in this bloggers opinion).. With regards to ADHD, the actual role of homocysteine is, admittedly, much more murky. While the mechanisms and overall physiology of an ADHD brain vs. a Parkinsons brain show acute differences (In ADHD, chemical imbalances between the "inside" and "outside" regions of a neuron exist, which can be chemically modified ...
Elevated homocysteine levels have been linked from everything from cancer to diabetes to autoimmune disorders to stroke (however, please note that these results are far from unanimous, there are a number of studies showing the contrary for each of the diseases listed. Furthermore, there is still some debate as to whether the high levels of homocysteine are a causal factor for these disorders or just another side effect or symptom of these disorders. Nevertheless, the near-ubiquitous presence of high homocysteine levels in so many diseases across the board should at least suggest that homocysteine-lowering efforts are of great potential benefit, at least in this bloggers opinion).. With regards to ADHD, the actual role of homocysteine is, admittedly, much more murky. While the mechanisms and overall physiology of an ADHD brain vs. a Parkinsons brain show acute differences (In ADHD, chemical imbalances between the "inside" and "outside" regions of a neuron exist, which can be chemically modified ...
Background Few data have been published on the association of variables of the insulin resistance syndrome and serum total homocysteine (tHcy), a putative risk factor for cardiovascular morbidity, in...
Objectives: This study aims to evaluate the relationship between serum homocysteine levels and atherosclerotic plaques in carotid arteries in female patients with rheumatoid arthritis (RA). ...
Plasma homocysteine levels in patients with deep venous thrombosis.: Increased risk of arterial and venous thromboembolic disease is well documented in the homo
A comprehensive study in this weeks PLoS Medicine shows levels of the amino acid, homocysteine, have no meaningful effect on the risk of developing coronary heart disease, closing the door on the previously suggested benefits of lowering homocysteine with folate acid once and for all.. Previous studies have suggested that high blood levels of homocysteine might be a modifiable risk factor for coronary heart disease, but in a detailed analysis of data from 19 unpublished and 86 published studies, led by Robert Clarke from the Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford, the researchers found that lifelong moderate elevation of homocysteine levels had no significant effect on the risk of developing coronary heart disease. The study findings suggest that extensive publication bias, together with methodological problems, has played a role in previous suggestions linking homocysteine with coronary heart disease risk.. In their analysis, the authors found ...
Folic acid, a B vitamin, is important for heart health, experts agree. The amount of homocysteine in the blood, a marker for heart disease, is regulated by folic acid. "High levels of homocysteine can lead to heart disease, and the way to combat high homocysteine is to take folic acid," says Michael Poon, MD, chief of cardiology at Cabrini Medical Center in New York. Aim for 1 milligram or 1,000 micrograms a day, he says. Homocysteine may damage the blood vessel walls and promote blood clots, and although studies have consistently shown that high levels are associated with an increased risk of heart disease, researchers are still not sure whether lowering the level of homocysteine reduces heart disease risk. But homocysteine levels are strongly influenced by diet, and several studies have shown that higher blood levels of B vitamins - specifically folic acid - are related, at least partly, to lower concentrations of homocysteine. Today, cereals, breads, and other grains like rice are fortified ...
Abstract: DESCRIPTION (adapted from the application): Although primary prevention strategies have focused on key modifiable risk factors for development and progression of atherosclerosis, such as hypercholesterolemia, coronary heart disease (CHD) remains the leading cause of death in the United States. Many individuals who present with clinical sequelae of atherosclerosis do not have identifiable conventional risk factors for CHD. Epidemiological studies indicate a strong association of plasma tHcy levels with atherosclerosis from childhood to the elderly. A large number of studies have shown plasma tHcy levels to be an independent risk factor for CHD that is easily modifiable with the B-vitamins, folic acid, vitamin B12, and vitamin B6. Plasma tHcy levels rise 25 % after 50 years of age and may partially account for the age-related risk for CHD. The rise in plasma tHcy levels parallel the age-related decrease in serum levels of folate, vitamin B12, and vitamin B6. Elevated they levels result ...
A current fact sheet of the WHO on CVDs states that most CVDs can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol using population-wide strategies [1]. The WHO also states that individuals with CVDs or individuals at high cardiovascular risk (due to the presence of one or more risk factors such as hypertension, diabetes, hyperlipidaemia or already established disease) need early detection and management [1]. However, some risk factors, like elevated blood pressure, mildly impaired endothelial function or moderately elevated homocysteine levels are first signs of vascular changes but are not always the reason for early treatment. First steps should be consequent lifestyle changes including healthier diet, increased physical activity, reduction of tobacco-use and alcohol-consumption [23]. Published studies demonstrate a beneficial effect of different nutritional ingredients on early symptoms of CVD, ...
CONTEXT: In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR 677C--|T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain. OBJECTIVE: To assess the relation of MTHFR 677C--|T polymorphism and risk of CHD by conducting a meta-analysis of individual participant data from all case-control observational studies with data on this polymorphism and risk of CHD. DATA SOURCES: Studies were identified by searches of the electronic literature (MEDLINE and Current Contents) for relevant reports published before June 2001 (using the search terms MTHFR and coronary heart disease), hand searches of reference lists of original studies and review articles (including meta-analyses) on this topic, and contact with investigators in the field. STUDY SELECTION: Studies were included if they
blood homocysteine is associated with a 10%lower risk of vascular disease.32 At present, the We have observed a significant decrease in upper limit of the reference range for homocys- homocysteine plasma levels on oral HRT, either teine is Ͻ15 ␮mol/. It seems, however, that car- alone or in combination with simvastatin-13% diovascular risk increases even at lower homo- and 10%, respectively. Previous studies on the cysteine concentrations for both stable coronaryrelation between HRT and homocysteine also patients and acute coronary syndrome patients,35 found a decrease in homocysteine levels in wo- and some authors propose that the desirable men receiving HRT. Some studies showed treat- homocysteine concentration should be Ͻ10 ment effects similar to the effect we found, be- tween 9% and 13%;21-23 other studies observed a Estrogen exert favorable effects on various bi- 7% reduction obtained by HRT.6,7 The addition ological parameters (lipids, fibrinolysis, endothe- of a progestin does not ...
Dietary Supplement S-Adenosyl--Methionine (AdoMet) Effects on Plasma Homocysteine Levels in Healthy Human Subjects: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Objectives: To determine if exogenous S-adenosyl--methionine (AdoMet), a commonly used nutritional supplement, increases the level of plasma homocysteine (Hcy), a potential cardiovascular risk fa.... ...
Furthermore, there is solid evidence that NAC helps boost the bodys levels of glutathione, one of the main antioxidants produced by the body. In particular, glutathione is critical to liver health. Many people suffer from elevated homocysteine levels, an amino acid that is a risk factor for cardiovascular disease. Several studies indicate that NAC can significantly lower homocysteine levels. Finally, if you sometimes drink alcohol and get a hangover, youll be interested to know that NAC plus vitamin B1 (thiamine) may help the body reduce the severity of hangovers. There are many other lesser known uses for NAC. Ill discuss more of these at the end of the article.. ...
Note: "Post-load" blood levels of homocysteine can be measured after giving a "load" of oral methionine, the precursor of homocysteine. Each 10% increase in homocysteine levels carried with it a 10% increase in the risk of developing heart disease. A similar percentage increase in cholesterol levels represents a 20% increased risk for heart disease. A 1999 study by Verhoef et al. was important because of its size and that it showed a positive correlation of risk of atherosclerosis with both "fasting" homocysteine levels and "post-load" homocysteine levels). The study showed that: (1) fasting homocysteine levels were lower in women than in men, (2) homocysteine levels were associated with age in both sexes, including post-menopausal women, (3) homocysteine levels after a methionine load were higher in women than in men, (4) in pre-menopausal women, low circulating levels of vitamin B6 increased the risk of vascular disease by two- to three-fold, independent of homocysteine, and (5) in men, low ...
Impaired MTHFR function has multiple negative impacts on DNA synthesis and repair, embryonic development, neurotransmitter synthesis, and cardiovascular risk factors. Cardiovascular Disease: The normal recycling of homocysteine to methionine relies on 5-MTHF. If there is a defect in the MTHFR enzyme, the result is lower levels of 5-MTHF and consequently, elevated levels of homocysteine. Hyperomocysteinemia is an independent risk factor for cardiovascular disease including atherosclerosis, heart attack, stroke and venous thrombosis from increased blood clots (Varga, E. et al. Circulation; 2005; 111: e289-e293).. Currently, only the C677T mutation is thought to be associated with elevated homocysteine levels and thus a majority of the research has been done on this variant. Cancer Risk: Appropriate DNA methylation is important for proper DNA replication. A disruption in methylation may occur due to a reduction 5-MTHF, which leads to a buildup of homocysteine. This eventually results in a drop in ...
Cardiac Disease from the Metabolic Syndrome (elevated homocysteine levels). Lack of Vitamin B-12 in our Diet. One of the primary reasons why we are seeing so many individuals being diagnosed with vitamin B-12 deficiency is because of the Western diet. We have been instructed to avoid red meats (the primary source of vitamin B-12). We have been advised to avoid eating seafood (a great source of vitamin B-12) due to heavy metal toxicity or it is too expensive to serve with any regularity. We have been advised to avoid saturated fats (there go the eggs and cheese). The primary meat on the dining room table today is chicken breast and it contains very little vitamin B-12 as you can see from the chart above.. Fruits, vegetables and grains do not contain any appreciable vitamin B-12 and these foods, along with boneless, skinless chicken breast, now make up the vast majority of our daily caloric intake. Additionally, we are seeing more and more vegans and vegetarians who are avoiding all the primary ...
B vitamins may slow brain shrinkage by as much as seven-fold in brain regions specifically known to be most impacted by Alzheimers disease. High levels of the amino acid homocysteine are linked to brain shrinkage and an increased risk of Alzheimers; B vitamins are known to suppress homocysteine Among participants taking high doses of folic acid and vitamins B6 and B12, blood levels of homocysteine were lowered as was the associated brain shrinkage - by up to 90 percent ...
Much of the research into the importance of folate and B12 levels has centered on seniors, and there is now quite a lot of research pointing to the need for adequate levels of these vitamins for maintaining cognitive functioning as you get older. In particular, high levels of homocysteine increase the risk of developing Alzheimers, and these go hand-in-hand with low levels of B12 and folate. Homocysteine is produced by the breakdown of a dietary protein called methionine, and B-vitamins are required to convert homocysteine back to methionine. Mouse research indicates that increased levels of homocysteine impair cognition through microvascular changes in the hippocampus. Greater brain atrophy is also found in those with high levels of homocysteine.. Elevated levels of homocysteine are not only associated with a significantly greater risk of developing Alzheimers, they also dramatically increase the risk for stroke and vascular dementia.. Excitingly, though, a study found that vitamin B ...
196 of 205 patients assigned to treatment of placebo were followed clinically and 177 had repeat angiography. There was no difference between groups in the following: average age 61 years, 22% were women, 40% were smokers, 28% diabetics, lipids, homocysteine (11μm/L), or treatment with statins (71%), beta blockers (65%), and ACIi (35%), use of stents (50%). Treatment lowered homocysteine levels from 11.1 +/- 4.3μm/L to 7.2 +/- 2.4 μm/L. The rate of restenosis was significantly lower on treatment (19.6% vs 37.6%, p = 0.01) as was the need for target vessel revascularization (10.8% vs. 22.3%, p = 0.047). The followup minimal luminal diameter and percent stenosis was also significantly better in the folate group. There was no difference in other coronary events. The benefit was predominately in those with PTCA without stenting ...
Hello, The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in regulating the levels of homocysteine. Elevated homocysteine level is a risk factor for ischemic stroke, thrombotic and cardiovascular diseases. This genetic condition do not cause bleeding and oozing...
Learn more about High Homocysteine at Grand Strand Medical Center Uses Principal Proposed Natural Treatments Folate ...
Researchers say that high levels of the amino acid homocysteine may increase the risk of brain atrophy and blood vessel disease, researchers report.
Vitamins May Help Prevent Bone Fractures. A new report published in the New England Journal of Medicine (2004, vol.350, no.20: 2033-2041) identifies folate and other B vitamins as important nutrients in helping ward off broken bones resulting from osteoporosis that may be caused by elevated homocysteine levels. The report examined two major studies from Rotterdam and Amsterdam involving 2,406 subjects age 55 or older. Subjects with the highest levels of homocysteine were nearly twice as susceptible to osteoporosis-related bone fractures compared to other subjects. B vitamins and folate are already recognized in helping reduce high levels of homocysteine that are linked to heart attacks, strokes, Alzheimers disease, and severe birth defects. Foods naturally rich in B vitamins in calcium include dairy products, broccoli and leafy green vegetables, carrots, avocados, cantaloupes and apricots among others. Note: Sunnie formula contains nutrients that are believed to reduce homocycstine. The ...
In my last post on homocysteine I discussed homocysteine as an extremely important lab marker that is rarely run. I discussed the optimal range being...
Plaque PLAQUE PROGRESSION REVERSED 1 American Journal of Hypertension. 2000;13(1 Pt 1):105-10.Ultrasound measurement of carotid plaque confirmed that daily doses of three B vitamins reversed the progression of plaque in patients with elevated homocysteine levels. Plaque regression was achieved with 2.5 mg folate, 25 mg B6, and 250 mcg B12 daily. The authors stated that […]. Read More ...
Dr. Stephanie Seneff, a Senior Research Scientist at the Massachusetts Institute of Technology (MIT), completed research in 2017 that concluded: "People who take cholesterol lowering drugs had over 2.5 times the risk of developing Alzheimers." The brain contains approximately 25% of the bodys total cholesterol, so restricting this essential fat is not good for the mind. Cholesterol is also a necessary precursor for many of our hormones, without which life is just not up to par. Read Hormones Make You Happy to understand more.. Add to this recent finding the fact that 50 YEARS ago, research showed that high cholesterol had little to do with arteriosclerosis, hardening of the arteries, and therefore heart disease.. Dr. Kilmer McCully discovered that cholesterol and clogged arteries are not the causes, but rather the symptoms of heart disease. McCullys research, published in the American Journal of Pathology in 1969, linked elevated homocysteine levels to heart disease, NOT cholesterol levels. ...