TY - JOUR. T1 - Cerebral blood flow autoregulation is impaired in schizophrenia. T2 - A pilot study. AU - Ku, Hsiao Lun. AU - Wang, Jiunn Kae. AU - Lee, Hsin-Chien. AU - Lane, Timothy Joseph. AU - Liu, I-Chao. AU - Chen, Yung Chan. AU - Lee, Yao Tung. AU - Lin, I Cheng. AU - Lin, Chia Pei. AU - Hu, Chaur-Jong. AU - Chi, Nai-Fang. PY - 2017/10. Y1 - 2017/10. N2 - Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls. None of the participants had a history of cardiovascular ...

Get this from a library! Arabidopsis inositol pentakisphosphate 2-kinase, AtIPK1, is required for growth and modulates phosphate homeostasis at the transcriptional level.. [HF Kuo; TY Chang; SF Chiang; WD Wang; YY Charng; TJ Chiou] -- Inositol hexakisphosphate (IP6 ) provides a phosphorous reservoir in plant seeds; in addition, along with its biosynthesis intermediates and derivatives, IP6 also plays important roles in diverse ...

Background. Despite several decades of research, the relevance of blood donation and iron homeostasis on cardiometabolic outcomes remains unclear. Objectives. This thesis aims to reliably characterise the relevance of blood donation and iron homeostasis on cardiometabolic outcomes while overcoming some limitations of previous studies. Data sources (i) 187,725 UK blood donors drawn from the general blood donor population and linked with hospital records; (ii) up to 40,000 blood donors from the INTERVAL trial, including data on ~30 million genetic variants, 6 iron biomarkers, 7 cardiometabolic markers and serial surveys; (iii) up to 890,000 participants from the UK Biobank and 4 external genetic consortia, with data on 21 cardiometabolic outcomes. Results. In an analysis of prospective observational data from up to 187,725 donors over a maximum of 11.2 years (median 3.3 years), a higher frequency of whole blood donation was associated with a lower risk of multiple cardiometabolic outcomes. ...

TY - JOUR. T1 - Homeostatic T cell proliferation in a T cell-dendritic cell coculture system. AU - Ge, Qing. AU - Palliser, Deborah. AU - Eisen, Herman N.. AU - Chen, Jianzhu. PY - 2002/3/5. Y1 - 2002/3/5. N2 - Naïve T cells do not proliferate in normal individuals in the absence of antigen stimulation, but they proliferate spontaneously when T cells are severely depleted. We show here that coculture of syngeneic dendritic cells (DC) with naïve T cells expressing a single T cell receptor also results in T cell proliferation in the absence of foreign antigen. As in lymphopenic mice, where T cell proliferation depends upon DC, this response in the coculture system requires interaction of the T cells T cell receptor with self-peptide-MHCs on DC. This in vitro proliferation also requires soluble factors, including IL-15 secreted by DC, and can be inhibited potently by cell-cell contact with CD4+CD25+ regulatory T cells. The coculture system described may illuminate mechanisms that maintain stable ...

Structure-function studies of 7TM G protein coupled receptors within in particular the immune system (cytokine and lipid receptors) and the endocrine system (incretin, neuropeptide, melanocortin, melatonin, lipid and orphan receptors). This includes the molecular basis for ligand recognition and receptor activation, action of allosteric and orthosteric agonists, antagonists, super- and inverse agonists. Identification of novel compounds by site-directed drug discovery methods and chemogenomics. Description of signalling phenomena such as constitutive activity, functional selectivity (biased activity) and receptor cross-talk.. Project description. The project based on human studies, will investigate the physiological effects of different dairy and non-dairy whole food matrices of postprandial gastro-intestinal hormone secretion and bone remodeling in healthy humans. The gut is involved in multiple homeostatic processes by releasing a series of gut hormones upon food intake, to promote anabolic ...

Title:Molecular Insights into Muscle Homeostasis, Atrophy and Wasting. VOLUME: 19 ISSUE: 5. Author(s):Bianca Maria Scicchitano*, Gabriella Dobrowolny, Gigliola Sica and Antonio Musaro*. Affiliation:Istituto di Istologia e Embriologia, Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Largo Francesco Vito 1-00168, Roma, Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Istituto di Istologia e Embriologia, Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Largo Francesco Vito 1-00168, Roma, Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome. Keywords:Muscle homeostasis, Muscle atrophy, Degradation of cell proteins, Muscle wasting, Anabolic pathways, Muscle pathologies.. Abstract:Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we ...

Homeostasis in the immune system encompasses the mechanisms governing maintenance of a functional and diverse pool of lymphocytes, thus guaranteeing immunity to pathogens while remaining self-tolerant. Antigen-naive T cells rely on survival signals through contact with self-peptide-loaded major histocompatibility complex (MHC) molecules plus interleukin (IL)-7. Conversely, antigen-experienced (memory) T cells are typically MHC-independent and they survive and undergo periodic homeostatic proliferation through contact with both IL-7 and IL-15. Also, non-conventional gammadelta T cells rely on a mix of IL-7 and IL-15 for their homeostasis, whereas natural killer cells are mainly dependent on contact with IL-15. Homeostasis of CD4(+) T regulatory cells is different in being chiefly regulated by contact with IL-2. Notably, increased levels of these cytokines cause expansion of responsive lymphocytes, such as found in lymphopenic hosts or following cytokine injection, whereas reduced cytokine levels cause a

Homeostatic proliferation is a normal physiological process triggered by lymphopenia to maintain a constant level of T cells. It becomes the predominant source of new T cells in adulthood after thymus regression. T cells that have undergone homeostatic proliferation acquire the memory phenotype, cause autoimmune disease, and are resistant to tolerance induction protocols. Transplantation is a rare example in which lymphopenia is deliberately induced for its immunosuppressive effect. However, it is not known whether the homeostatic proliferation that follows will have the opposite effect and accelerate rejection. We show that T cells that have undergone homeostatic proliferation acquire a memory phenotype, spontaneously skews toward the Th1 phenotype, even in the absence of antigenic stimulus. Interestingly, in contrast, the percentage of Foxp3(+) regulatory T cells increased by 28-fold following homeostatic proliferation. Using a mouse life-sustaining kidney transplant model, we showed that T cells that

Iron is an essential element needed by all organisms for growth and development. Because iron becomes toxic at higher concentrations iron is under homeostatic control. Plants face also the problem that iron in the soil is tightly bound to oxygen and difficult to access. Plants have therefore developed special mechanisms for iron uptake and regulation. During the last years key components of plant iron regulation have been identified. How these components integrate and maintain robust iron homeostasis is presently not well understood. Here we use a computational approach to identify mechanisms for robust iron homeostasis in non-graminaceous plants. In comparison with experimental results certain control arrangements can be eliminated, among them that iron homeostasis is solely based on an iron-dependent degradation of the transporter IRT1. Recent IRT1 overexpression experiments suggested that IRT1-degradation is iron-independent. This suggestion appears to be misleading. We show that iron ...

How cells coordinate growth and division is key for size homeostasis. Phosphorylation by G1-CDK of Whi5/Rb inhibitors of SBF/E2F transcription factors triggers irreversible S-phase entry in yeast and metazoans, but why this occurs at a given cell size is not fully understood. We show that the yeast Rim15-Igo1,2 pathway, orthologous to Gwl-Arpp19/ENSA, is up-regulated in early G1 and helps promoting START by preventing PP2ACdc55 to dephosphorylate Whi5. RIM15 overexpression lowers cell size while IGO1,2 deletion delays START in cells with low CDK activity. Deletion of WHI5, CDC55 and ectopic CLN2 expression suppress the START delay of igo1,2 cells. Rim15 activity increases after cells switch from fermentation to respiration, where Igo1,2 contribute to chromosome maintenance. Interestingly Cln3-Cdk1 also inhibits Rim15 activity, which enables homeostatic control of Whi5 phosphorylation and cell cycle entry. We propose that Rim15/Gwl regulation of PP2A plays a hitherto unappreciated role in cell ...

Iron (Fe) homeostasis is essential for plant growth and development. Although tremendous progress has been made in understanding the maintenance of Fe homeostasis in plants, the underlying molecular mechanisms remain elusive. Recently, bHLH11 was reported to function as a negative regulator. However, the molecular mechanism by which bHLH11 regulates Fe homeostasis is unclear. Here, we generated two bhlh11 loss-of-function mutants which displayed the enhanced sensitivity to excessive Fe. bHLH11 is located in the cytoplasm and nucleus due to lack of a nuclear location signal sequence, and its interaction partners, bHLH IVc transcription factors (TFs) (bHLH34, bHLH104, bHLH105 and bHLH115) facilitate its nuclear accumulation. bHLH11 exerts its negative regulation function by recruiting the corepressors TOPLESS/TOPLESS-RELATED. Moreover, bHLH11 antagonizes the transactivity of bHLH IVc TFs towards bHLH Ib genes (bHLH38, bHLH39, bHLH100 and bHLH101). This work indicates that bHLH11 is a crucial component of

Findings about chronic complex diseases are difficult to extrapolate from animal models to humans. We reason that organs may have core network modules that are preserved between species and are predictably altered when homeostasis is disrupted. To test this idea, we perturbed hepatic homeostasis in mice by dietary challenge and compared the liver transcriptome with that in human fatty liver disease and liver cancer. Co-expression module preservation analysis pointed to alterations in immune responses and metabolism (core modules) in both human and mouse datasets. The extent of derailment in core modules was predictive of survival in the cancer genome atlas (TCGA) liver cancer dataset. We identified module eigengene quantitative trait loci (module-eQTL) for these predictive co-expression modules, targeting of which may resolve homeostatic perturbations and improve patient outcomes. The framework presented can be used to understand homeostasis at systems levels in pre-clinical models and in ...

copper (Cu) is an essential nutrient for vertebrates and has numerous functions in cellular physiology, including respiration, free-radical defense, angiogenesis, neuronal function, and others (20). In mammals, copper acquisition is initiated by the absorption of dietary copper across the intestinal epithelium, and copper excess is removed by the liver with biliary secretion into the gastrointestinal tract, and excretion with the feces (45, 46). Liver is the major organ to regulate copper homeostasis at the whole body level, by either recycling copper into newly synthesized serum proteins, or clearing copper out of the body (43). Daily dietary copper uptake in the average adult is in the range of 0.6-1.6 mg, and secretion into bile and pancreatic juice is on the order of 4.5 mg/day (47). Most of the copper secreted with the bile into the alimentary canal is reabsorbed by enterocytes, and only a small portion is completely cleared out of the body (29). The biosynthetic requirement for copper in ...

Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc.

Table 1: p66|sup|Shc|/sup| Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain

The conventional model of intestinal epithelial architecture describes a unidirectional tissue organizational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they progress along the vertical (crypt-luminal) axis. In this model, the fate of a cell that has left the niche is determined and its lifespan limited. Evidence is accumulating to suggest that stem cell control and daughter cell fate determination is not solely an intrinsic, cell autonomous property but is heavily influenced by the microenvironment including paracrine, mesenchymal, and endogenous epithelial morphogen gradients. Recent research suggests that in intestinal homeostasis, stem cells transit reversibly between states of variable competence in the niche. Furthermore, selective pressures that disrupt the homeostatic balance, such as intestinal inflammation or morphogen dysregulation, can cause committed progenitor cells and even some differentiated cells to regain

In this study, we demonstrated for the first time that two ALS‐linked Sig1R variants, including the novel p.L95fs mutation, are unstable and lose their abilities to bind IP3R3 and to control Ca2+ homeostasis at the MAM. A recent crystallographic study of Sig1R revealed that a pair of hydrogen bonds formed by Glu102, Val36, and Phe37 in Sig1R tethers its cytosolic domain to the transmembrane domain (Schmidt et al, 2016), providing a structural explanation for instability of the ALS‐linked Sig1R variants. Moreover, ALS‐linked Sig1R variants were unable to control the Ca2+ flux in Sig1R‐depleted neuronal cells. Taken together, we concluded that the loss‐of‐function mechanism is mainly responsible for Sig1R‐linked ALS.. Our results also indicate that a loss of Sig1R is sufficient for inducing collapse of the MAM in vivo for the first time. Electron microscopic study revealed dissociation of ER and mitochondria at the MAM in the motor neurons of Sig1R−/− mice. Although there are a ...

BACKGROUND & AIMS: Activation factor-1 transcription factor family members activating transcription factors 2 and 7 (ATF2 and ATF7) have highly redundant functions owing to highly homologous DNA binding sites. Their role in intestinal epithelial homeostasis and repair is unknown. Here, we assessed the role of these proteins in these conditions in an intestine-specific mouse model. METHODS: We performed in vivo and ex vivo experiments using Villin-CreERT2Atf2fl/flAtf7ko/ko mice. We investigated the effects of intestinal epithelium-specific deletion of the Atf2 DNA binding region in Atf7-/- mice on cellular proliferation, differentiation, apoptosis, and epithelial barrier function under homeostatic conditions. Subsequently, we exposed mice to 2% dextran sulfate sodium (DSS) for 7 days and 12 Gy whole-body irradiation and assessed the response to epithelial damage. RESULTS: Activating phosphorylation of ATF2 and ATF7 was detected mainly in the crypts of the small intestine and the lower crypt ...

Recently, microarray and bioinformatics analysis have been widely used in identifying potential targets for diagnosis and therapy of different cancers. In the present study, a total of 883 DEGs were screened, including 600 upregulated DEGs and 283 downregulated DEGs. We then performed functional enrichment analysis on the DEGs. For the upregulated DEGs, GO terms were significantly enriched in binding at MF level, organelle at CC level and cellular process at BP level. For the downregulated DEGs, most enriched GO terms were binding at MF level, extracellular region part at CC level and chemical homeostasis at BP level. Most of these GO terms were basic regulatory concepts in cell. Pathway enrichment analysis revealed that cell cycle, p53 signaling pathway and pathways in cancer were significantly enriched, which were associated with the occurrence of cancers. In addition, we constructed the PPI network and analyzed the top five modules. KEGG pathway analysis revealed that the DEGs in these ...

The long-term goals of this proposal are to delineate how humans regulate and integrate heme homeostasis at the organismal level. Heme, an iron containing organ...

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The nucleolus is considered to be a stress sensor and rDNA-based regulation of cellular senescence and longevity has been proposed. However, the role of rDNA in the maintenance of genome integrity has not been investigated in detail. Using genomically diverse industrial yeasts as a model and array-based comparative genomic hybridization (aCGH), we show that chromosome level may be balanced during passages and as a response to alcohol stress that may be associated with changes in rDNA pools. Generation- and ethanol-mediated changes in genes responsible for protein and DNA/RNA metabolism were revealed using next-generation sequencing. Links between redox homeostasis, DNA stability, and telomere and nucleolus states were also established. These results suggest that yeast genome is dynamic and chromosome homeostasis may be controlled by rDNA. ...

Regulatory T cells help maintain intestinal homeostasis by preventing inappropriate innate and adaptive immune responses. CD4(+) T cells that express Foxp3 and Tr1-like cells that produce IL-10 comprise the major regulatory populations in the intestine. CD4(+)Foxp3(+) T cells play an important functional role in promoting tolerance of the flora and dietary proteins. Tr1-like cells can be generated in conditions that also promote effector T cell responses and may serve a similar function. In this review, we discuss the signals specific to the gastrointestinal tract that support both regulatory cell types and their distinct modes of action in the mesenteric lymph nodes and intestinal tissues. Dysregulation of intestinal immune homeostasis occurs in inflammatory bowel disease and can also be observed in graft-versus-host disease, tumor immunotherapy regimens, and acute HIV infection.

Various studies have shown that dietary, environmental, and host-derived factors have a strong effect on the makeup and action of this significant microbial organ (De Filippo et al., 2010; Maurice et al., 2013; Goodrich et al., 2014). This homeostatic role of IgA in regulating commensal bacteria was lately confirmed in people using IgA deficiency (Fadlallah et al., 2018). In reality, a substantial portion of commensal bacteria has been proven to be coated with IgA and stably maintained in homeostatic conditions (van der Waaij et al., 1996). More recently, we demonstrated that diversification and choice of IgA repertoires at a T-cell-dependent manner in germinal centres of the Peyers patches contribute to improving the diversity and stability of both gut-resident species (Kawamoto et al., 2014). Additionally, T-independent pathways, likely originating from the lamina propria, have already been shown to contribute to the generation of an IgA repertoire thats polyreactive into a wide swathe of ...

Background Cytoplasmic pH homeostasis in Escherichia coli includes numerous mechanisms involving pH-dependent catabolism and ion fluxes. An important contributor is transmembrane K+ flux, but the actual basis of K+ compensation for pH stress remains unclear. Osmoprotection could mediate the pH protection afforded by K+ and other osmolytes. Methods and Principal Findings The cytoplasmic pH of E. coli K-12 strains was measured by GFPmut3 fluorimetry. The wild-type strain Frag1 was exposed to rapid external acidification by HCl addition. Recovery of cytoplasmic pH was enhanced equally by supplementation with NaCl, KCl, proline, or sucrose. A triple mutant strain TK2420 defective for the Kdp, Trk and Kup K+ uptake systems requires exogenous K+ for steady-state pH homeostasis and for recovery from sudden acid shift. The K+requirement however was partly compensated by supplementation with NaCl, choline chloride, proline, or sucrose. Thus, the K+ requirement was mediated in part by osmolarity, possibly by

TY - JOUR. T1 - A20 controls intestinal homeostasis through cell-specific activities. AU - Vereecke, Lars. AU - Vieira-Silva, Sara. AU - Billiet, Thomas. AU - van Es, Johan H. AU - Mc Guire, Conor. AU - Slowicka, Karolina. AU - Sze, Mozes. AU - van den Born, Maaike. AU - De Hertogh, Gert. AU - Clevers, Hans. AU - Raes, Jeroen. AU - Rutgeerts, Paul. AU - Vermeire, Severine. AU - Beyaert, Rudi. AU - van Loo, Geert. PY - 2014. Y1 - 2014. N2 - The transcription factor NF-κB is indispensable for intestinal immune homeostasis, but contributes to chronic inflammation and inflammatory bowel disease (IBD). A20, an inhibitor of both NF-κB and apoptotic signalling, was identified as a susceptibility gene for multiple inflammatory diseases, including IBD. Despite absence of spontaneous intestinal inflammation in intestinal epithelial cell (IEC) specific A20 knockout mice, we found additional myeloid-specific A20 deletion to synergistically drive intestinal pathology through cell-specific mechanisms. A20 ...

Cholesterol is an amphipathic sterol compound that exerts both structural and physiological tasks in the plasma membrane of all eukaryotic cells. The planar and rigid structure of this molecule regulates the fluidity of the phospholipid bilayer and its permeability to solutes and ions. The structural role of cholesterol is particularly relevant in the central nervous system, where it represents one of the major components of myelin sheaths, and an important constituent of the synaptic vesicle membranes. The synthesis and trafficking of cholesterol is highly specialized in the brain, and displays several differences if compared to its metabolism in other tissues. In humans, disruption to cholesterol homeostasis can lead to a wide spectrum of pathological conditions.

Peripheral T cells, in absence of a thymus (4, 25) or when transferred to T cell-deficient hosts (5, 7, 26), are capable of considerable expansion. The sequential transfer of a T cell population into successive hosts has shown that one T cell can generate up to 1015 cells (7). This indicates that in a normal mouse, peripheral T cell division is limited by mechanisms that probably include resource competition and complex cell interactions (9). We studied the role of T cell interactions in the control of the number of peripheral CD4+ T cells. In particular, we investigated if CD25+CD4+ T cells, which exert regulatory functions (27, 28, 29, 30, 31, 32), could also govern peripheral CD4+ T cell homeostasis.. IL-2Rα−/− mutant mice are reported as a paradigm for perturbed lymphocyte homeostasis (10). The lack of the IL-2Rα was believed to impair AICD in vivo (10), to modify the balance between clonal expansion and cell death, resulting in the deregulation of both the size and content of the ...

Taurine (Tau) regulates β-cell function and glucose homeostasis under normal and diabetic conditions. Here, we assessed the effects of Tau supplementation upon glucose homeostasis and the morphophysio

TY - JOUR. T1 - Klf15 orchestrates circadian nitrogen homeostasis. AU - Jeyaraj, Darwin. AU - Scheer, Frank A.J.L.. AU - Ripperger, Jürgen A.. AU - Haldar, Saptarsi M.. AU - Lu, Yuan. AU - Prosdocimo, Domenick A.. AU - Eapen, Sam J.. AU - Eapen, Betty L.. AU - Cui, Yingjie. AU - Mahabeleshwar, Ganapathi H.. AU - Lee, Hyoung Gon. AU - Smith, Mark A.. AU - Casadesus, Gemma. AU - Mintz, Eric M.. AU - Sun, Haipeng. AU - Wang, Yibin. AU - Ramsey, Kathryn M.. AU - Bass, Joseph. AU - Shea, Steven A.. AU - Albrecht, Urs. AU - Jain, Mukesh K.. PY - 2012/3/7. Y1 - 2012/3/7. N2 - Diurnal variation in nitrogen homeostasis is observed across phylogeny. But whether these are endogenous rhythms, and if so, molecular mechanisms that link nitrogen homeostasis to the circadian clock remain unknown. Here, we provide evidence that a clock-dependent peripheral oscillator, Krüppel-like factor 15 transcriptionally coordinates rhythmic expression of multiple enzymes involved in mammalian nitrogen homeostasis. In ...

This report presents results of a genome scan for glucose homeostasis phenotypes in large families of African-American and Hispanic-American descent. The analyses support evidence of familial aggregation of glucose homeostasis phenotypes, multiple regions of linkage to AIRG on chromosome 11p, and strong evidence for linkage of DI to chromosome 11q.. There have been few genome scans that have evaluated directly measured phenotypes of glucose homeostasis, in contrast to numerous studies that have reported linkage to measures based on fasting values alone, including fasting glucose, fasting insulin, and/or the HOMA index. These surrogate measures of physiological processes appear to have different genetic architecture from these directly measured parameters (8). Three studies with the preferred direct measurements of glucose homeostasis are the FUSION (Finland-U.S. Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics) study (31), the study of hypertension and insulin resistance in ...

The major research focus of my laboratory is to explore FGF signaling in the context of retinal Müller cell biology. Müller glial cells are well known for their roles in tissue homeostasis and for their trophic support of neurons. Like other glia of the CNS, Müller cells undergo a series of changes upon injury, hypoxia and disease states like diabetic retinopathy and glaucoma. These changes, named reactive gliosis, involve altered gene expression and enhanced proliferation. Though gliosis is thought to be an attempt to keep the tissue homeostasis, it often contributes to retinal pathology. In addition to homeostatic roles, at least a subpopulation of Müller cells have potential to transdifferentiate to neurons upon injury to replace the lost ones. ...

Adipocytes are key cells in metabolic homeostasis. They are very useful for creating models for studying metabolic diseases such as obesity and diabetes.

The changes that are part of normal metabolism may be internal or external, and the organism must respond â ¦ MedicineNet does not provide medical advice, diagnosis or treatment. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Feedback Loop A system used to control the level of a variable in which there is an identifiable receptor (sensor), control center (integrator or comparator), effectors, and methods of â ¦ homeostasis - Maintaining a constant internal environment. homeostasis Quick Reference n. the physiological process by which the internal systems of the body (e.g. 1 doctor agrees Send thanks to the doctor 90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Homeostasis medical definition, flashcards and ICD-10 codes. It refers to how a person under conflicting stresses and motivations can maintain a stable psychological ...

Exploring how our bodies work and function. The Homeostasis & Heat Regulation chart explains the concept of homeostasis using the bodys responses to environmental changes in temperature. A diagram showing a generalized process of homeostasis is followed by graphic representations and descriptions of heat transfer modes. The bottom portion of the chart is devoted to the bodys response to heat and cold.. Item: 8281. ...

identification of internal states, monitoring positives and negatives, and the realities of progressively positive human development. It is also important in experiencing joy and happiness. Lets review some core characteristics of homeostasis; it will soon become clear that meditative equanimity and homeostasis have many things in common. Perhaps human homeostasis and equanimity have deep innate, naturalistic tendencies in some people. Here are some characteristics.. ...

This term is often used when discussing holistic remedies including those involving CBD. In this episode well explore what it means for your body to be in homeostasis, what contributes and what takes from homeostasis. | What is Homeostasis? Friday, September 11, 2020 on The CBD Ed Show Ed Chaney | VoiceAmerica - The Leader in Internet Media

pH balance or pH homeostasis in humans commonly refers to the internal balance of the bodys electro-magnetic and chemical systems in response to the changing conditions of the external world and the changing conditions of the internal world. The word homeostasis comes from the Greek words: homeo means similar or alki or alkaline and stasis means a tendency toward maintaining stability. There are many homoeostatic mechanisms in our bodies that help maintain this balance and our state of health is directly related to the health of these mechanisms. pH homeostasis is maintained by dynamic processes of feedback and regulation. pH homeostasis has only one objective: to preserve the beneficial conditions of life in the internal alkali environment. Every day we are bombarded with external influences that threaten that balanced internal alkaline pH environment. Some of these threats include becoming too hot or too cold, eating too much or eating acidic foods or drinks, breathing polluted air ...

Daria Sicari, Aeid Igbaria, Eric Chevet. Control of Protein Homeostasis in the Early Secretory Pathway Current Status and Challenges. Cells, MDPI, 2019, 8 (11), pp.E1347. ⟨10.3390/cells8111347⟩. ⟨hal-02365417⟩ ...

Sigma-Aldrich offers abstracts and full-text articles by [Hitesh S Deshmukh, Yuhong Liu, Ogechukwu R Menkiti, Junjie Mei, Ning Dai, Claire E OLeary, Paula M Oliver, Jay K Kolls, Jeffrey N Weiser, G Scott Worthen].

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TY - JOUR. T1 - Functional characterization of the rice SPX-MFS family reveals a key role of OsSPX-MFS1 in controlling phosphate homeostasis in leaves. AU - Wang, C.. AU - Huang, W.. AU - Ying, Y.. AU - Li, S.. AU - Secco, David. AU - Tyerman, S.. AU - Whelan, James. PY - 2012. Y1 - 2012. U2 - 10.1111/j.1469-8137.2012.04227.x. DO - 10.1111/j.1469-8137.2012.04227.x. M3 - Article. VL - 196. SP - 139. EP - 148. JO - The New Phytologist. JF - The New Phytologist. SN - 0028-646X. ER - ...

The epidermis forms a critical barrier that is maintained by orchestrated programs of proliferation, differentiation, and cell death. Gene mutations that disturb this turnover process may cause skin diseases. Human GASDERMIN A (GSDMA) is frequently silenced in gastric cancer cell lines and its overexpression has been reported to induce apoptosis. GSDMA has also been linked with airway hyperresponsiveness in genetic association studies. The function of GSDMA in the skin was deduced by dominant mutations in mouse gasdermin A3 (Gsdma3), which caused skin inflammation and hair loss. However, the mechanism for the autosomal dominance of Gsdma3 mutations and the mode of Gsdma3s action remain unanswered. We demonstrated a novel function of Gsdma3 in modulating mitochondrial oxidative stress. We showed that Gsdma3 is regulated by intramolecular fold-back inhibition, which is disrupted by dominant mutations in the C-terminal domain. The unmasked N-terminal domain of Gsdma3 associates with Hsp90 and is delivered

The brain plays a critical role in a wide variety of functions including behaviour, perception, motor control, and homeostatic maintenance. Each function can undergo different selective pressures over

View Notes - #4 NS 160 Cellular Nutrient Sensing from NST 160 at Berkeley. Cellular nutrient Sensing III Part I: Regulation of Iron Homeostasis Part II: Nuclear Hormone Receptors IRON

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I read online that there are CD4+ T-cells in the mucosa walls in the small intestine that can stimulate other t-cells and therefore maintain immune homeostasis, is that correct or have I just read a rubbish website? Also my lecturer wants me to talk about how enzymes influence homeostasis in the small intestine but I cant find anything anywhere that explains this ...

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It is well established that neurons employ a variety of mechanism to homeostatically stabilize firing rates in response to bidirectional perturbations of network activity that would deviate firing rates from a defined set point. These mechanisms include regulation of intrinsic excitability (Marder & Goaillard, 2006), shift in the inhibition excitation balance (Maffei et al, 2004; Gonzalez‐Islas & Wenner, 2006), compensatory changes in excitatory synaptic strength (Turrigiano & Nelson, 2004), and modulation of synapse number (Kirov et al, 1999; Wierenga et al, 2006). Which form of homeostatic response is used depends on the developmental stage of the neurons, the form and time of stimulation and can involve both cell‐wide and local adaptations (Turrigiano, 2008; Yu & Goda, 2009). A large body of work has begun to elucidate the molecular mechanisms of adaption to a chronic decrease in network activity, as, for example, induced by the application of tetrodotoxin (Turrigiano, 2012). However, ...

The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance and regeneration is central to normal development and ageing, and to organismal survival during periods of acute stress. How energy metabolism and stem-cell homeostatic processes are coordinated is not well un …