BACKGROUND: The aim of this study was to determine the role of the ST segment elevation resolution , 50% between the ECG before and 2 hours after thrombolytic therapy as a predictor of acute myocardial infarction (AMI)-related artery patency, assessed by a coronary angiography performed 1 month after AMI.. MATERIALS AND METHODS: This study enrolled 95 patients, 75 men and 20 women, 58 years mean aged, admitted to the coronary care unit with diagnosis of AMI. Patients were treated with thrombolysis within 6 hours from the onset of chest pain, according to the GUSTO trial.. RESULTS: The findings showed a significant prevalence of ST segment elevation resolution , 50% in inferior AMI (p , 0.01). It has been observed that the ST segment resolution is correlated with lower (p , 0.01) and earlier (p , 0.05) peak in serum creatinekinase (CK) and CK MB release and with less damage of left ventricular ejection fraction assessed by ventriculography (p , 0.01). All these findings indicated a lower ...
Three cases of definite stent thrombosis (2 in the mesh stent group, 1 in the BMS group) occurred, with none resulting in death. There were no differences between the groups in infarct size.. Interventionalists Must Balance Pros and Cons. The MGuard is specifically designed f or thrombus-containing lesions. Previously, the MASTER trial, presented at Transcatheter Cardiovascular Therapeutics in October 2012 and simultaneously published in the Journal of the American College of Cardiology, demonstrated an increased rate of complete ST-segment resolution with MGuard compared with conventional BMS and DES. In an email with TCTMD, Dr. Fernández-Cisnal noted that while the stent has been reported to be a useful device for reducing distal microembolization in STEMI patients, as measured by myocardial blush grade and ST-segment resolution, no differences have been observed in clinical endpoints. "Higher, but nonsignificant, rates of TLR and TVR were observed in some studies [that compared the MGuard] ...
Josep del Hoyo, IBC1227538. Video of Forest Owlet Heteroglaux blewitti at Melghat Tiger Reserve, India. Accessible at hbw.com/ibc/1227538 ...
Derived from Strategic Transactions, Informas premium source for tracking life sciences deal activity, the Dealmaking column is a survey of recent health care transactions listed by relevant industry segment - In Vitro Diagnostics, Medical Devices, and Pharmaceuticals - and then categorized by type - Acquisition, Alliance, or Financing. This months column covers deals announced in August 2017. ...
Rufous-fronted Wood-quail 23-28 cm; estimated weight of male 340 g, of female 329 g. Very similar to O. melanotis. Bare ring around eye purple (male) or black (female)#R; overall coloration c
Even though the electrocardiogram (ECG) is the standard diagnostic test for the evaluation of symptoms of acute myocardial ischemia or infarction, the prognostic value of various ECG features of cardiac ischemia is ill-defined. Savonitto and colleagues conducted a retrospective study of the ECG findings among patients in the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes (GUSTO-IIb) trial.. A total of 12,142 patients were enrolled in the GUSTO-IIb trial. To be enrolled in the study, patients had to have ECG signs of myocardial ischemia, including transient or persistent ST-segment elevation or depression of more than 0.05 mV or persistent and definite T-wave inversion of more than 0.1 mV. All patients had to have reported symptoms of cardiac ischemia at rest within 12 hours of hospital admission. Since the GUSTO-IIb trial was a comparison of heparin and desirudin, patients were excluded if they had active bleeding, a history of stroke, an elevated serum creatinine ...
Visit your doctor or health care professional for regular check ups. Your condition will be monitored carefully while you are receiving this medicine.. Notify your doctor or health care professional and seek emergency treatment if you develop breathing problems; changes in vision; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm, or leg. These can be signs that your condition has gotten worse.. Avoid sports and activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your doctor or health care professional.. If you are going to have surgery, tell your doctor or health care professional that you have received this medicine.. ...
On 11 June 2013, UNITAID announced in a press statement that it was committing USD $77 million to end of the use of the archaic HIV drug d4T (stavudine) ...
Expedia launched its London usability lab back in November, so Travolution decided to catch up with Tammy Snow, director of global user experience resea...
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The primary role of platelets in arterial thrombotic occlusion has been documented in patients with coronary artery disease1 as well as in animal models.2 3 Besides its central role in the coagulation cascade,4 thrombin is a potent platelet agonist and thus constitutes an interesting target for drugs that would prevent the formation of fibrin- and platelet-rich thrombi induced by thrombin.. Recently, new specific thrombin inhibitors such as hirudin and hirulog, which are derived from Hirudo medicinalis,5 were shown to be promising new antithrombotics in various animal models and tested in clinical situations associated with coronary thrombosis.6 7 8 9 Their superiority over heparin has been predicated on the fact that for a similar prolongation of the activated partial thromboplastin time (aPTT), the specific thrombin inhibitors were more antithrombotic than heparin.10 11 12 13 14 15 16 Today, the aPTT has wide acceptance in clinical use and is used to monitor heparin therapy for the prevention ...
METHODS AND RESULTS Seven thousand patients with acute myocardial infarction and a duration of symptoms of less than 6 hours were to be randomized to receive intravenous heparin (70 IU/kg body wt bolus and 15 IU.kg-1.h-1) or hirudin (0.4 mg/kg body wt bolus and 0.15 mg.kg-1.h-1) infused over 48 to 72 hours and adjusted to an activated partial thromboplastin time of 2 to 3.5 times baseline values. In a pilot phase, 1000 patients receiving front-loaded alteplase for thrombolysis were to be recruited by 93 German centers. After enrollment of 302 patients, the trial was stopped after an increased rate of intracranial bleeding was observed in the hirudin group (5 of 148, 3.4%) compared with the heparin group (0 of 154). The overall stroke rate was 3.4% in the hirudin group and 1.3% in the heparin group. Other major bleeding occurred in five versus three patients and ventricular rupture occurred in three versus one patient in the hirudin and heparin groups, respectively. There were 19 in-hospital ...
Lepirudin (brand name Refludan) is an anticoagulant drug, derived from the saliva of the leech and used in the treatment of high-risk thromboembolic patients who have heparin-induced thrombocytopenia and thus are not able to take heparin.
A more aggressive approach has been demonstrated to provide control of status epilepticus within 30 minutes of initiation: Loading dose: 0.5 mg/kg followed by 0.12 mg/kg/hour (2 mcg/kg/minute). If seizures persist or recur, administer 0.5 mg/kg bolus with an increase in the infusion rate to 0.24 mg/kg/hour (4 mcg/kg/minute); if seizures continue to persist/recur, administer 0.1 mg/kg bolus and increase infusion to 0.48 mg/kg/hour (8 mcg/kg/minute); continue to repeat this last incremental increase until seizure control or a maximum dose of 1.44 mg/kg/hour (24 mcg/kg/minute) is reached; do not allow ,5 minutes to elapse between each dose increment while seizures persist (dose range within clinical trial: 0.12-1.92 mg/kg/hour or 2-32 mcg/kg/minute) (Morrison, 2006 ...
ETSI - Producing globally applicable standards for ICT-enabled systems, applications & services deployed across all sectors of industry and society. Made in Europe for global use.
Researchers at Oita University, Japan, have created a new process for producing H2 from ammonia with rapid initiation that requires no external heat source, giving hope for the increased global use of H2 as an efficient and clean energy source.
Global time infrastructure is critical to a secure and reliable Internet. Well promote the development and global use of better security processes and mechanisms for network time synchronization.
chains in the Genus database with same CATH superfamily 2LXP C; 4TU4 A; 5CUB A; 4BW4 A; 2YQL A; 4QYL A; 4FIP A; 5FE4 A; 2E7O A; 2RFJ A; 4QSS A; 5LVR A; 2C2V S; 5E74 A; 5HLS A; 5C85 A; 2I8N A; 5FE9 A; 5KU3 A; 4O71 A; 5FH7 A; 1WEQ A; 5B79 A; 2IDA A; 1VD4 A; 4PPE A; 2YT5 A; 5ENJ A; 5HEN A; 4UIY A; 4QNS A; 5IGM A; 4O7A A; 5CQ4 A; 2LV9 A; 5CUC A; 5ENC A; 2MIQ A; 2PNX A; 3U5J A; 5FB1 A; 5HQ5 A; 5HM0 A; 5I7X A; 3ZYQ A; 2EGP A; 5EWD A; 4X2I A; 2YQD A; 3GV4 A; 5HQ6 A; 5LUU A; 2E6R A; 4A9F A; 5HEM A; 1T1H A; 4MSX A; 4N3W A; 3N9P A; 4TT6 A; 5C8G A; 5A82 A; 2KR4 A; 3N9M A; 1E4U A; 3S92 A; 1WEE A; 5IGN A; 5FE8 A; 5J0D A; 5K29 A; 4NR6 A; 4L7X A; 4LLB A; 4A9H A; 3D7C A; 5I83 A; 2YUR A; 4A4B A; 5ETB A; 2VJF A; 2WP1 A; 4A9N A; 3I2D A; 5TAB A; 4IOQ A; 5H1V A; 5G4R A; 4YYK A; 5KTU A; 4MEP A; 5E73 A; 4CLB A; 5A5P A; 4TKP B; 2LN0 A; 3FKM X; 2FSA A; 2CT2 A; 4QSQ A; 2YW8 A; 2VPB A; 5IBN A; 2L0B A; 5DKH A; 3U5M A; 2CKL A; 4HBW A; 1F68 A; 5CFW A; 2YW5 A; 4UYF B; 4YY6 A; 3ZYU A; 4UYF A; 4CUU A; 3MUK A; 4NR5 A; 1WEW A; ...
This prospective cohort study shows that the Export and Diver catheters are both safe and effective in removing thrombus in an unselected population with ST-segment elevation myocardial infarction. The larger internal lumen diameter of the Diver catheter did not result in retrieval of larger thrombotic particles, nor in improved angiographic or electrocardiographic outcomes.. Primary PCI does not always result in successful reperfusion of the myocardium, despite a patent epicardial vessel. Mechanical crushing and fragmentation of the thrombus-containing lesion during primary PCI is thought to be at least partly responsible for myocardial dysfunction after PCI (13-15). Several devices have been introduced to facilitate removal of thrombus and plaque material, thereby protecting the microvasculature and improving myocardial blood flow. In saphenous vein graft PCI, distal embolic protection devices have proven to be very effective in preventing distal embolization (class I recommendation, level of ...
OBJECTIVES: I. Determine the dose, safety, and antitumor response rate of lepirudin in patients with recurrent or extensive stage small cell lung cancer previously treated with chemotherapy.. OUTLINE: This is a dose escalation (in individual patients) study. Patients receive dose escalated lepirudin subcutaneously once or twice a day for 3-4 days. Dose escalation continues in each patient until aPTT prolongation occurs or the maximum dose level is reached. The patient then continues treatment on the maximum tolerated dose. Treatment continues in the absence of disease progression or unacceptable toxicity.. PROJECTED ACCRUAL: A total of 20-35 patients will be accrued for this study within 18-24 months. ...
The aim of this study was to evaluate the efficacy and safety of enoximone, an imidazolonic compound inhibiting cardiac phosphodiesterase III, during the postoperative period. The drug was administered prior to the usual stages of weaning the patient off extracorporeal circulation, to a group of 20 subjects who presented an ejection fraction of less than 35% following hemodynamic studies. Patients were randomly subdivided into 4 groups each of which received a different dose of enoximone according to the following protocol: Group A, 1 mg/kg bolus and slow infusion at 10 gamma/kg/min; Group B, 0.5 mg/kg bolus and slow infusion at 15 gamma/kg/min; Group C, 0.5 mg/kg bolus and slow infusion at 10 gamma/kg/min; Group D, slow infusion at 10 gamma/kg/min. The best results in hemodynamic terms and with regard to the positive inotropic and vasodilatory action of the drug in question were obtained in Group C. Increased cardiac output was observed in all patients within 120 minutes of enoximone administration and
First prequalification for pneumococcal disease vaccine - a life-threatening disease affecting many children; follows first-ever World Pneumonia Day
BERLIN, Feb. 21, 2019 /PRNewswire/ -- Abbott (NYSE: ABT) today announced data from three real-world evidence studies that provide a comprehensive look at the global use of the FreeStyle® Libre flash glucose monitoring system and its impact on health outcomes for people living with diabetes. The new real-world eviden...
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Once upon a time, somebody created "The Food List Challenge," a selection of 100 foods and drinks that the author believed everyone should try before they die. I looked through the list recently and discovered there were many I had not tried - and some that I didnt even know where I could try them... Read more » ...
TY - JOUR. T1 - Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient. AU - Knoderer, Chad A.. AU - Knoderer, Holly M.. AU - Turrentine, Mark. AU - Kumar, Manjusha. PY - 2006/5. Y1 - 2006/5. N2 - A 21-month-old boy received anticoagulation with lepirudin for heparin-induced thrombocytopenia (HIT) after undergoing cardiac surgery and receiving extracorporeal membrane oxygenation (ECMO). This report illustrates the significance of HIT in pediatric patients after cardiac surgery and the successful administration of lepirudin in this setting. To our knowledge, this is the first published report of lepirudin administered to treat HIT in a child after cardiac surgery and ECMO. Although guidelines exist that suggest the potential administration of lepirudin as treatment for children with HIT, further studies are needed to determine the safest yet most effective dosage for this population.. AB - A 21-month-old boy received anticoagulation with ...
TY - JOUR. T1 - The influence of infusions of 1-desamino-8-D-arginine vasopressin (DDAVP) in vivo on the anticoagulant effect of recombinant hirudin (CGP39393) in vitro. AU - Ibbotson, S H. AU - Grant, P J. AU - Kerry, R. AU - Findlay, V S. AU - Prentice, C R. PY - 1991/1/23. Y1 - 1991/1/23. N2 - Hirudin is a specific, potent inhibitor of thrombin that may be a valuable antithrombotic agent. The aim of this study was to investigate the hypothesis that the haemostatic effects of DDAVP counteract the coagulation defect induced by hirudin. The effect of DDAVP was studied in vivo on the anticoagulant action of recombinant hirudin (CGP39393) in vitro. Blood samples were taken at intervals from 10 normal volunteers infused with DDAVP. Factor VIII:C rose from (mean) 0.68 IU/ml before DDAVP to 2.19 and 2.16 IU/ml after 30 and 60 min infusion, respectively. Samples taken during DDAVP infusion showed a dose related decrease in the hirudin (0.5 and 1.0 microM) induced prolongation of the APTT, that ...
Live from AHA 2017 Dr. Datta from VERSEON Pharmaceuticals discusses a new Direct Thrombin Inhibitor in Phase 1 Clinical Development., TV Network
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 3qx5: Thrombin Inhibition By Pyridin Derivatives
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 3qtv: Thrombin Inhibition By Pyridin Derivatives
Many people are shocked to learn that 25 percent of all new homes ultimately suffer from some type of structural distress. Many times, these issues center on foundation problems. To protect yourself from unwieldy repair costs, learn how identify telltale signs of a bad foundation.. What Causes Foundation Failure?. While just about every foundation eventually sinks deeper into the ground, a good builder should take steps to mitigate this occurrence. This includes factoring in local climate and soil conditions during the construction process. When they fail to account for these issues, builders may inadvertently pave the way for a foundation dilemma.. At the same time, natural phenomena can also cause perfectly good foundations to lose their structural integrity. Whatever the cause, when foundations begin to fail, homeowners are often left with the bill, especially if they failed to acquire a long-term structural warranty.. What to Watch for. Its not always easy for inexperienced house hunters to ...
Systematics. The whydahs and indigobirds, together with the Cuckoo Finch (Anomalospiza imberbis), constitute the family Viduidae, a group confined to the Afrotropical Region, occurring only in the sub-Saharan part of the continent. All of the species are brood-parasitic, laying their eggs in the nests of other species; the hosts rear the young viduids along with their own young. The family consists of two genera, the monotypic Anomalospiza, with the Cuckoo Finch, and Vidua, which consists of 19 species of whydah and indigobird. The brood-parasitic Viduidae and the waxbills (Estrildidae), which are their primary host species, diverged about 20 million years ago. Several morphological characters support a close relationship between Anomalospiza and Vidua and are different from those of the weavers (Ploceidae). Most significantly, the skull, the bony palate, the horny palate and the pterylosis of Anomalospiza are much like those of Vidua and unlike those of the other Old World ...
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En la premieree gringa de Iglorious Basterds se pudo ver a los jolie-pitt tan sexies como siempre, aunque no me gusto la barba de pitt ...
Sviluppo massa magra. Scopri le barrette proteiche ed energetiche anche senza glutine da VitaminCenter. Integra con gusto le proteine alla tua dieta grazie a VitaminCenter.it
In this Cochrane meta-analysis, researchers analyzed the overall efficacy and safety of direct thrombin inhibitors, compared to warfarin or LMWH, in preventing VTE after orthopedic surgeries (hip and knee arthroplasty). In14 studies involving over 20,000 participants, they found no difference in efficacy between direct thrombin inhibitors, warfarin, or LMWH, but did find higher mortality and bleeding in the thrombin group compared to LMWH (but no difference between the thrombin group and warfarin) (abstract). The timing of the thrombin inhibitors also matters, as pre-operative dosing results in fewer VTEs but likely higher bleeding. Dabigatran is the oral direct thrombin inhibitor that is currently approved in Canada and throughout Europe, but US FDA approval is pending.. ...
Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various diseases. They inhibit thrombin, a serine protease which affects the coagulation cascade in many ways. DTIs have undergone rapid development since the 90s. With technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs. Before the use of DTIs the therapy and prophylaxis for anticoagulation had stayed the same for over 50 years with the use of heparin derivatives and warfarin which have some well known disadvantages. DTIs are still under development, but the research focus has shifted towards factor Xa inhibitors, or even dual thrombin and fXa inhibitors that have a broader mechanism of action by both inhibiting factor IIa (thrombin) and Xa. A recent review of patents and literature on thrombin inhibitors has demonstrated that the development of allosteric ...
The European Bird Census Council (EBCC):. The European Bird Census Council (EBCC) officially adopted the HBW and BirdLife International Illustrated Checklist of the Birds of the World as their reference for nomenclature and taxonomy. It will be implemented in all of the supra-national projects coordinated by EBCC, including the European Breeding Bird Atlas, EuroBirdPortal and Pan-European Common Bird Monitoring Scheme.. With this latest resolution the HBW-BirdLife Illustrated Checklist increases its influence as the taxonomy and nomenclature followed by most European countries.. The European Union:. The European Union adopted the HBW and BirdLife International Illustrated Checklist of the Birds of the World as the standard reference for bird taxonomy and nomenclature. It is used most importantly for the EUs official list of birds, which guides the Birds Directive, whose goal is to protect all of the wild bird species naturally occurring in the European Union. This list is also used for the ...
N(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide: thrombin inhibitor; RN given refers to parent cpd without isomeric designation
... Will direct thrombin inhibitor excel with high-dose clopidogrel on bo...CHICAGO March 29 /- A large randomized trial will shedl...The Intracoronary Stenting and Antithrombotic Regimen: Rapid EarlyAct...Bivalirudin has outperformed unfractionated heparin in some previouss...,ISAR-REACT,3,Pits,Bivalirudin,vs.,Unfractionated,Heparin,in,PCI,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Two drugs that are direct inhibitors of thrombin but that do not involve antithrombin III or vitamin K in their mechanism of action have been approved to
Abstract Thrombolysis is the current standard of care for ischemic stroke. In order to better understand its underlying mechanisms, a closer look at the basic... ...
This article was reported by NAM aidsmap. NAM aidsmap reported that the World Health Organization (WHO) recently released new hepatitis C treatment ...
Handbook of the Birds of the World Alive (HBW Alive) er et nettleksikon som samler alle verdens fugler og eies og driftes av Lynx Edicions, i samarbeid med BirdLife International. Nettstedet er en elektronisk versjon av oppslagsverket «Handbook of the Birds of the World» og oppdateres kontinuerlig med nyheter og endringer. Det inkluderer også alle relevante data fra første bind (lansert i juli 2014) av det 904 sider store oppslagsverket «HBW and BirdLife International Illustrated Checklist of the Birds of the World»[2], som blant annet Den europeiske union (EU) har valgt som offisiell standard for taksonomi og nomenklatur av ikke-passerine fugler (altså unntatt spurvefugler), og det vil inkludere alle relevante data fra andre bind, når det lanseres i desember 2016. Nettstedet er organisert i 36 ordener med tilhørende familier, slekter, arter og underarter. Det er rikt illustrert og alle artikler er utfyllende og grundig dokumentert med bibliografiske referanser, ofte med lenker til ...
The generic name of Pradaxa is Dabigatran which is an anticoagulant medication orally administered to the patient, it belongs to the class of direct thrombin inhibitor.
The highest DNA binding by 3-NBA in ES cells was observed at 10 μM after 24 h with 863 ± 74 adducts per 108 nucleotides (Fig. 3C). Interestingly, and in contrast to BaP, adduct levels for 3-NBA in MEFs were only 1.5-fold higher. (1266 ± 188 adduct per 108 nucleotides) under the same experimental conditions (Fig. 3D). DNA binding LDK378 in vivo was highest in MEFs at 10 μM after 48 h with 2478 ± 455 adducts per 108 nucleotides. Previously, in primary HUFs previously treated with 10 μM 3-NBA for 48 h, adduct levels were 680 ± 147 adducts per 108 nucleotides (Kucab et al., 2012). As 3-NBA is predominantly activated by NQO1 (Arlt et al., 2005), the expression of Nqo1 was studied in ES cells and MEFs by RT-PCR and revealed that Nqo1 mRNA expression increased in both cell types up to ∼60-fold; the induction was higher in MEFs than in ES cells ( Fig. 6C and D). This is in line with a previous study showing that Nqo1 protein levels were inducible in primary and immortal HUFs upon treatment with ...
Watching the Olympic Games and other international sports venues demonstrates the global use of pre-competition warm-up and stretching exercises by
Nåtidsfuglenes basale klader i etterkomertreet under er i henhold til Sibley & Ahlquist (1990)[3]. Inndelingen støttes i hovedtrekk av nyere forskning med genom, jfr. Jarvis et al. (2014). Det er imidlertid uklart om Tinamidae (tinamufamilien) og flere andre familier skal inkluderes i selvstendige ordener under Paleognathae (primitive nåtidsfugler) eller som familier under Struthioniformes (strutsefugler). Det siste støttes av HBW Alive. ...
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This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.