TY - JOUR. T1 - Pregnancy, prescription medicines and the potential risk of herb-drug interactions. T2 - a cross-sectional survey. AU - McLay, James S.. AU - Izzati, Naila. AU - Pallivalapila, Abdul R.. AU - Shetty, Ashalatha. AU - Pande, Binita. AU - Rore, Craig. AU - Al Hail, Moza. AU - Stewart, Derek. N1 - All funding was from institutional resource. JSM, AS are employed by the University of Aberdeen. DS is employed by the Robert Gordon University. BP and CR are employed by NHS Scotland. ARP and MAH are employed by the Hamad Medical Corporation. Qatar. NI is a postgraduate student at the University of Aberdeen. PY - 2017/12/19. Y1 - 2017/12/19. N2 - Background: Pregnant women are routinely prescribed medicines while self-medicating with herbal natural products to treat predominantly pregnancy related conditions. The aim of this study was to assess the potential for herb-drug interactions (HDIs) in pregnant women and to explore possible herb-drug interactions and their potential clinical ...
Editors Note: NCCAM has posted a free online lecture by Professor Bill J. Gurley, Ph.D., Department of Pharmaceutical Sciences and Clinical Pharmacokinetics Laboratory at the College of Pharmacy, University of Arkansas for Medical Sciences. The lecture identifies factors that contribute to the risk for herb-drug interactions, mechanisms involved in herb-drug interactions, and how new technologies in supplements and drugs may impact herb-drug interaction.. ...
Among the 400 patients, 237 (59.3 %) used at least one medicinal herb. Compared to other studies this is a high percentage and similar to previous studies from our country where 51.9 % of diabetic patients reported taking herbs [7] and 85.7 % of hypertensive patients used at least one type of complementary and alternative medicines. Of the users, 62.1 % reported taking herbs [8]. According to the World Health Organization (WHO), about 70 % of the world population use medicinal herbs as complementary or alternative medicine [12], so the use of herbal remedies is common worldwide.. The herbs used by patients in this study are relatively safe because most herbs used here are also edible plants used in cooking so they are not some unknown plants that might be toxic. However, even these plants can have potential drug-herb interactions. In 21.5 % of the users in this study at least one potential drug-herb interaction was found. In a study on patients using dietary supplements in two American cities, ...
Ginko Biloba is a popular herb for overall brain function and memory. It also has a thinning effect on the blood. One of the ways the body works to stop bleeding is by the action of platelets. When platelets come in contact with damaged blood vessel walls they stick together. Ginko biloba inhibits the stickiness of platelets. It should not be taken with other drugs that inhibit blood clots such as warfarin, non-steroidal anti-inflammatories (NSAIDs), and other blood thinners. Ginko may also interact with anti-seizure medications including carbamazepine, phenytoin, and phenobarbital. People taking certain diuretic medications (thiazide diuretics) should not take Ginko as it may cause an increase in blood pressure ...
Abstract:. Background: The influence of poly-herbal formulation (Mehagni) on allopathic drug like glibenclamide mainly on plasma glucose level, lipid level and pharmacokinetic parameters in patients with type-2 diabetes mellitus. Methods and Result: Open-label, randomized clinical study was carried out for 90 days. Around 75 patients were screened out, based on their medication subjects were divided into group A&B 39 patients were in glibenclamide-2.5 mg (Daonil®) therapy and 36 patients were in poly-herbal formulation (Mehagni-500 mg, 2 tab/thrice a day) from past 6 months. Again 39 patients of glibenclamide therapy subdivided into group A1&A2. Group A1 (20) patients reviving glibenclamide-2.5 mg and group A2 (20) for combined study (GLB-1.5 mg+Mehagni 2 tab/twice a day). Initial day the study, analyze baseline demographic and clinical characteristics and that data was compared with end of the study report, in group A2 the high density lipoproteins (HDL) significantly increased as compared to ...
There is a possibility that the effect of tea on blood pressure might differ from that of pure caffeine. There are few data on the effect of tea on blood pressure in patients treated with antihypertensives. One study in stable hypertensive patients taking beta blockers, calcium-channel blockers, nitrates and ACE inhibitors reported that 450 ml of black tea (containing approximately 190 mg of caffeine) increased systolic blood pressure by 5 mmHg two hours after consumption. This effect was similar to the increase seen with a single dose of 200-mg of caffeine. Drinking 900 mL of black tea daily for 4 weeks had no significant effect on blood pressure. However, the acute effects of tea remained: systolic blood pressure was still increased by 5 mmHg two hours after the patients drank 450 mL of black tea.There are a number of short-term intervention studies on the effect of tea on blood pressure, mainly in healthy subjects or patients with untreated mild hypertension. In one meta-analysis of 5 ...
Red vine leaf contains a range of polyphenolics, mainly flavonoids, proanthocyanins and anthocyanins. The major flavonoids in the extract are quercetin and isoquercitrin. Catechins present include gallocatechin and epigallocatechin and their polymers. The red colour is due to the anthocyanins, which are mainly glucosides of malvidin, but also of delphinidin, cyanidin and pertunidin. Hydroxy-cinnamic acids (e.g. caffeic acid) and resveratrol are also present.. ...
TY - JOUR. T1 - Multiple ABC Transporters Efflux Baicalin. AU - Kalapos-Kovács, Bernadett. AU - Magda, Balázs. AU - Jani, Márton. AU - Fekete, Zsolt. AU - Szabó, P.. AU - Antal, I.. AU - Krajcsi, Péter. AU - Klebovich, I.. PY - 2015/12/1. Y1 - 2015/12/1. N2 - Baicalein, the aglycone formed by hydrolysis of baicalin in the intestine, is well absorbed by passive diffusion but subjected to extensive intestinal glucuronidation. Efflux of baicalin, the low passive permeability glucuronide of baicalein from enterocytes, likely depends on a carrier-mediated transport. The present study was designed to explore potential drug-herb interaction by investigating the inhibitory effect of baicalin on the transport of reporter substrates by transporters and to identify the transporters responsible for the efflux of baicalin from enterocytes and hepatocytes. The interaction of baicalin with specific ABC transporters was studied using membranes from cells overexpressing human BCRP, MDR1, MRP2, MRP3 and ...
In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant.
Despite increased awareness of the potential of herb-drug interactions (HDIs), the lack of rigorous clinical evidence regarding the significance provides a challenge for clinicians and consumers to make rational decisions about the safe combination of herbal and conventional medicines. This review addressed HDIs based on evidence from randomized controlled trials (RCTs). Literature was identified by performing a PubMed search till January 2017. Risk description and clinical risk management were described. Among 74 finally included RCTs, 17 RCTs (22.97%) simply addressed pharmacodynamic HDIs. Fifty-seven RCTs (77.03%) investigated pharmacokinetic HDIs and twenty-eight of them showed potential or actual clinical relevance. The extent of an HDI may be associated with the factors such as pharmacogenomics, dose of active ingredients in herbs, time course of interaction, characteristics of the object drugs (e.g., administration routes and pharmacokinetic profiles), modification of herbal
How to integrate plants into your life, soul, and medicine, and how to decide which remedy is the "right" one. Learn simple plant dowsing techniques and consider herb-drug interactions.. For more information and Registration: 800-829-0918. Payment: $40/ ...
This (admittedly awkwardly-titled) group of enzymes system metabolizes thousands of endogenous (from within) and exogenous (from outside) chemicals. Some seem to play more of a role in drug metabolism than others, and therefore get more scrutiny. 6 of these 50 enzymes metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. (If youve ever punished yourself by reading herb-drug interaction research papers, these may look familiar.) These enzymes are located in many cells of the body, but are especially concentrated in the liver. (For cell physiology enthusiasts, they are located either in the inner membrane of mitochondria, or in the endoplasmic reticulum of cells.). How do these enzymes work? CYP450 enzymes essentially make compounds more soluble so they can be excreted by the body. This enzyme system is a component of Phase 1 detoxification. You might be familiar with Phase 1, 2, and 3 metabolism in the liver. You can think of phase 1 as modification. In ...
Prediction may be envisaged as organized thinking about the possible. For this purpose, dynamic models of the state-variable approach are important tools because they combine basic knowledge on the physical, chemical and physiological processes that underlie crop growth and agricultural production. At one extreme are comprehensive models that claim to integrate all aspects of growth and to focus attention on the main gaps in present operational knowledge. As such, they are research tools. At the other extreme are summarizing models that are especially geared to answer w hat-if questions and are used for evaluating regional production potentials and constraints, for irrigation management and integrated control of pests, diseases and weeds. Examples of these types of models are given and their usefulness for predictive purposes is discussed. ...
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences ...
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences ...
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences ...
Maternity Nursing I. Basic Knowledge on Genetics and Obstetrics 1. DNA - Deoxyribonucleic Acid - carries genetic code 2. Chromosomes - threadlike structure...
The Healthy Communities Research Centre at UQ Ipswich is calling for a national focus on health literacy following the release of findings which reveal that most Australians dont have the basic knowledge to keep themselves healthy.
There are some good reasons why natural remedies for RLS are a preferred solution to conventional medications. Conventional medications are temporarily effective, but they have side effects (such as fatigue, dry mouth, weight gain, and brain fog), and their powers may be limited. "The medicines tend to stop working after 2 or 3 years, though […]. ...
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It is said that there are over 100 different training methodologies available to ... Tell the trainee what youre going to train. ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 24933a-NjNiM
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): multi-input, multi-output feed-back control design for linear systems using the paradigms, theory, and tools of robust con-trol that have arisen during the past two decades. The book is aimed at graduate students and practicing engineers who have a basic knowledge of classical con-trol design and state-space con-trol theory for linear systems. A basic knowledge of matrix theory and linear algebra is required to appreciate and digest the material offered. This edition is a revised and expanded version of the first edition, which was published in 1996. The size of the
The Center of Excellence for Natural Product-Drug Interaction Research (NaPDI) provides leadership in the study of natural product-drug interactions, with the ultimate goal of developing a definitive approach to determine the clinical relevance of pharmacokinetic interactions between natural products (NPs) and conventional medications.
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Health, Safety and Environment (HSE) considerations are vital to every enterprise. Moreover, HSE requirements in the workplace are laid down in a whole range of laws, regulations and guidelines. The employer has the primary responsibility for providing a suitable, safe working environment - and for ensuring sufficient training. This "HSE Introduction" provides you with the basic knowledge you need to know to be able to deal with HSE challenges in your daily work ...
Populations in developing areas of this region lack basic knowledge of biology and physiology, so it is imperative that educators use simple techniques when teaching nutrition.
No Boy Scout will ignore a plea for help. However, the desire to help is of little use unless one knows how to give the proper aid. The main purpose of the Lifesaving merit badge is to prepare Scouts to assist those involved in water accidents, teaching them the basic knowledge of rescue techniques, the skills to perform them, and the judgment to know when and how to act so that they can be prepared for emergencies ...
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28th Feb, 2018: This one-day course offers an introduction to the uses and functions of the statistical software Stata including data entry and manipulation, do-files, and the basics of analyses and graphs. The course is ideally suited to those with little/no experience with Stata, but basic knowledge of statistics is advantageous. ...
Well, theres a little bit of land called Kashmir that should be basic knowledge for anyone who has passed Freshmen level World History. Muslims and...
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Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions exist between selected commercially available herbal products (i.e., Linctagon Forte®, Viral Choice® and Canova®) and indinavir in terms of in vitro transport and metabolism. Bi-directional transport of indinavir was evaluated across Caco-2 cell monolayers in the presence and absence of the selected herbal products and verapamil (positive control). Metabolism of indinavir was determined in LS180 cells in the presence and absence of the selected herbal products as well as ketoconazole (positive control). The secretory transport of indinavir increased in a concentration dependent way in the presence of Linctagon Forte® and Viral Choice® when compared to that of indinavir alone. Canova® only slightly affected the efflux of indinavir compared to that of the control group. There
1. Depression Treatment- One of the scientifically proven St Johns Wort benefits is that this herb increases serotonin levels in the brain. This effect is the reason that the herb is commonly used to treat depression. 2. Anxiety Treatment- With the proper St Johns Wort dosage the herb can be effective for treating anxiety and related conditions. The effect that St. Johns Wort has on many of the neurotransmitters in the brain makes it a good choice for this disorder. 3. Smoking Cessation Support- St Johns Wort can help lessen the withdrawal symptoms and cravings that you experience when you stop smoking cigarettes. 4. PMS Treatment- Treating PMS is one of the top St Johns Wort benefits for many women. The use of this herb can minimize or even eliminate the symptoms of PMS and provide relief. 5. Obsessive Compulsive Treatment- St Johns Wort depression treatment is well known. What is less known is that this herb can also help treat obsessive compulsive disorder and certain other mental ...
It has been well reported that complementary medicines can significantly alter the way the body handles conventional drugs, leading to potential fatal herb-drug interactions. The aim of the present study was to investigate the molecular mechanism of drug interactions involving St Johns wort (SJW) (Hypericum perforatum L), a popular herbal medicine widely used for depression, particularly examining changes in the expression of cytochrome P450 CYP3A, the most abundant drug metabolising CYP enzymes in man. Eighteen Sprague-Dawley (SD) rats were assigned randomly into 3 groups (n = 6/group): control, low dose and high dose (500 and 1000 mg/kg/day of SJW, equal to 1500 and 3000 μg/kg/day of Hypericin). Each group was treated with SJW or control preparation, by gastric gavage, for 14 consecutive days. Liver and intestinal CYP3A activity and protein and mRNA levels, from fi ve segments of the intestine, were examined using CYP3A-dependent erythromycin N-demethylation activity assay, quantitative ...
Echinacea is the name of a genus of native North American plants, commonly known as the purple coneflower. The most widely used herbal product in the United States is a liquid extract made from the root of Echinacea purpurea. Because the active component of the plant has not been identified, commercial echinacea products are not typically standardized to any particular component. The research literature on echinacea is difficult to evaluate because of the heterogeneity of the products used in various studies. The herb has been recommended as a prophylactic treatment for upper respiratory infection and is widely used for this indication. However, based on the current literature, it appears that prophylactic echinacea does not have a significant impact on the frequency, severity, or duration of upper respiratory infection. The data regarding treatment of upper respiratory infection appear to support a modest positive effect. No significant herb-drug interactions with echinacea have been reported; adverse
The Schisandraceae family is reported to have a range of pharmacological activities, including anti-inflammatory effects. As with all herbal preparations, extracts of Schisandra species are mixtures composed of ,50 lignans including schizandrins and deoxyschizandrins. In China, Schisandra sphenanthera extract (SSE) is often co-administered with immunosuppressant treatment of transplant recipients. In cases of co-administration, the potential for herb-drug interactions (HDI) increases. Clinical studies have been employed to assess HDI of extracts including SSE. Clinical results demonstrated that chronic SSE administration reduced midazolam (MDZ) clearance by 55.4% in healthy volunteers. While clinical studies are definitive and considered the "gold standard", these studies are impractical for routine HDI assessments. Alternatively, in vitro strategies can be utilized to reduce the need for clinical studies. Transporter Certified™ human hepatocytes in sandwich-culture (SCHH) provide a fully ...
Get tips on using 5-HTP supplements once you talk with your doctor about them. Here's a partial list of possible drug-herb interactions.
Of course, you could experience side effects from taking valerian root. First of all, you need to ensure it wont interfere with other medications and supplements you may be taking.. The Clinical Pharmacology and Therapeutics journal published a study in 2005 that concluded that valerian had no measurable herb-drug interaction, but its best to talk to your doctor.. Some people may have trouble digesting and breaking down this natural remedy, which could cause stomachaches and prevent people from falling asleep.. Consuming valerian for insomnia may obviously cause drowsiness, so it shouldnt be taken before driving or other activity that requires your full attention.. Phytomedicine published a study in 2006 in which valerian was reported as being safe with no side effects. In this study, valerian seemed to positively impact sperm quality. If you are having trouble sleeping AND conceiving, it may be worth your while to contact a naturopath to discuss what valerian could do for you.. ...
BACKGROUND: Food/Herb-drug interactions have become a major problem in health care. These interactions can lead to loss of therapeutic efficacy or toxic effects of drugs. AREAS OF UNCERTAINTY: To probe the clinical relevance of such interactions, the impact of food/herb intake on the clinical effects of drug administration has to be evaluated. Failure to identify and efficiently manage food-drug interactions can lead to serious consequences. A comprehensive knowledge of the mechanisms that underpin variability in disposition will help optimize therapy ...
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Bio Health Hyperidrine (St Johns Wort) is a traditional herbal medicinal product used to relieve the symptoms of slightly low mood and mild anxiety, based on traditional use only.
Find patient medical information for ST JOHNS WORT on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it.
St Johns Wort has a lot of evidence backing up its use for mild depresssion. It can safely be tried while observing a few sensible cautions.
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