2. Loukas M, Fergurson A, Louis RG et-al. Multiple variations of the hepatobiliary vasculature including double cystic arteries, accessory left hepatic artery and hepatosplenic trunk: a case report. Surg Radiol Anat. 2006;28 (5): 525-8. doi:10.1007/s00276-006-0138-4 - Pubmed citation ...
TY - JOUR. T1 - Clinical significance of reconstruction of the right hepatic artery for biliary malignancy. AU - Sakamoto, Yoshihiro. AU - Sano, Tsuyoshi. AU - Shimada, Kazuaki. AU - Kosuge, Tomoo. AU - Kimata, Yoshihiro. AU - Sakuraba, Minoru. AU - Yamamoto, Junji. AU - Ojima, Hidenori. PY - 2006/6. Y1 - 2006/6. N2 - Background and aims: The clinical significance of resectional surgery with reconstruction of the right hepatic artery for biliary malignancy remains unclear. Patients/methods: Between 1990 and 2004, six patients (5%) with cholangiocarcinoma and five patients (3%) with gallbladder carcinoma with possible involvement of the right hepatic artery underwent resectional surgery with reconstruction of the right-sided hepatic artery. The surgical procedures included extended left hemihepatectomy (n=4), left trisectionectomy (n=1), central bisegmentectomy (n=1), resection of anterior segment and inferior area of segment 4 (n=2), resection of segment 5 and inferior area of segment 4 (n=1), ...
The left and right hepatic arteries make up the two branches of the common hepatic artery and are used for supplying blood to the liver within the human body.
The common hepatic artery is the vessel which supplies oxygen-rich blood to a number of important organs: the liver, the duodenum, the pylorus, and the pancreas. This artery is a branch of the celiac artery; it divides into the gastroduodenal artery and the hepatic artery proper.. ...
Purpose: This study was designed to evaluate the safety of chemotherapeutic infusion or chemoembolization by way of the cystic artery in patients with hepatocellular carcinoma (HCC) supplied exclusively by the cystic artery. Methods: Between Jan 2002 and Dec 2011, we performed chemotherapeutic infusion or chemoembolization using iodized oil for the treatment of 27 patients with HCC supplied exclusively by the cystic artery. Computed tomography (CT) scans, digital subtraction angiograms, and medical records were retrospectively reviewed by consensus. Results: The cystic artery originated from the main right hepatic artery in 24 (89 %) patients, from the right anterior hepatic artery in 2 (7 %) patients, and from the left hepatic artery in 1 (4 %) patient. Selective catheterization of the cystic artery was achieved in all patients. Superselection of tumor-feeding vessels from the cystic artery was achieved in 7 patients (26 %). Chemotherapeutic infusion was performed in 18 patients (67 %), and ...
Cystic artery is usually a branch of right hepatic artery given in the Calot s triangle. Variations in the origin of cystic artery have been reported but there is paucity of literature regarding these in Indian subjects. The present case describes the origin of cystic artery from the hepatic artery proper, with an unusual course, which was detected during routine cadaveric dissection. The development of biliary vasculature is quite complex and it accounts for many variations. Knowledge of cystic artery variability facilitates intraoperative identification of vessels in both classical and laparoscopic surgery of the bile ducts. This emphasises the importance of a thorough knowledge of the cystic arterial variations that often occur and may be encountered during both laparoscopic and open cholecystectomy. Uncontrolled bleeding from the cystic artery and its branches is a serious problem that may increase the risk of intraoperative lesions to vital vascular and biliary structures during ...
On the right side of the lesser curvature of the stomach, identify the right gastric artery, which is a branch of the proper hepatic artery. It lies along the lesser curvature of the stomach and anastomoses with the left gastric artery. The left gastric artery originates directly from the celiac trunk. It runs on the posterior wall of the lesser sac, covered by the gastropancreatic fold, to the superior aspect of the lesser curvature of the stomach Attempt to identify the esophageal branches of the left gastric artery which supply the abdominal portion of the esophagus. Along the anterior and posterior aspects of the lesser curvature of the stomach, identify the gastric branches of both the right and left gastric arteries (Figure 38.1).. Links and References: ...
Discharge Instructions for Hepatic Angiography You had a procedure called hepatic angiography. This is an X-ray study of the blood vessels that supply your liver. During the procedure, a catheter (thin, flexible tube) was inserted into one of your blood vessels through a small incision. A specially trained doctor called an interventional radiologist usually does the procedure. Heres what to do at home afterward.. Home care ...
See also hepatic artery above for additional text and references.. Anson studied the cystic artery in detail and the results of that study follow:. "The primary source of the cystic arteries is still of the classical variety, that is to say, they arise from the closest possible source (the right ramus of the hepatic artery proper). This form is the most common. Other sources occur - to make a total of twelve types encountered in a study of 800 specimens. The twelve types fall conveniently into four categories:. Group I. The cystic artery artery arises from a ramus of the proper hepatic artery, or from the latter at the point of division, or from the same vessel proximal to the point of division, or from the same vessel proximal to the point of bifurcation (a to d). In succession, and in the order of decreasing frequency, these are: from the right ramus of the hepatic proper in 63.9%; at the latter vessel at the point of bifurcation in 10.4%; from the left ramus in 5.5%; and from the hepatic ...
Transcatheter arterial chemo-embolization (TACE) is a therapeutic procedure to treat primary and metastatic liver cancer. It requires prior delineation of the hepatic arteries on magnetic resonance angiography (MRA) data and identification of the vessels supplying the tumor. Manual segmentation is extremely challenging and time consuming, thereby increasing the risk of wrongfully identifying the feeding vessels. We present a vascular path planning tool for TACE procedures by automatically segmenting the hepatic arteries on MRA. The proposed method first detects the celiac trunk from the aorta, then localizes and tags bifurcations throughout the arterial network for path planning. The algorithm is based on a multiple hypothesis tracking approach used to propagate deformable mesh surfaces. We validated the proposed framework on 20 liver-cancer-patients using abdominal MRA with 20 seconds delay after contrast injection. We show that the algorithm improves the selectivity of the arterial segments ...
1.Impaired vasoconstriction in animals with cirrhosis is maintained in isolated vessels in vitro, indicating an intrinsic alteration in function or structure of the cells in the vascular wall. This may be due to receptor down-regulation, a defect in post-receptor signal transduction or overproduction of vasodilator compounds. This investigation examined the role of these mechanisms in modulating α-adrenoceptor-mediated contraction in hepatic arteries from patients with advanced cirrhosis.. 2.Hepatic arteries were obtained from subjects with and without cirrhosis for functional investigation in vitro. Endothelial cell function was assessed using endothelium-dependent (acetylcholine) and independent (3′-morpholinosydnonimine) vasodilators. α-Adrenoceptor-mediated contraction was assessed by constructing cumulative concentration-response curves to the α1-selective agonist phenylephrine, the non-selective adrenoceptor agonist noradrenaline and the receptor-independent vasoconstrictor potassium ...
Kaplan-Meier analysis of PFS. Progression-free survival rate at 12 months after first embolization. PFS was defined as time from start of treatment until disease progression or death as a result of any cause. Response and progression endpoints refer specifically to hepatic metastases. Extrahepatic metastases were included for assessment of response and progression by RECIST version 1.0. Progressive Disease (PD): At least a 20% increase in the SLD of target lesions, taking as reference the smallest SLD recorded since the treatment started ...
The images of the tumor.Notes: (A) CT showed a low-intensity VX2 tumor (arrow) in the left liver lobe. (B) Selective left hepatic artery angiogram before TAE, s
The primary objective of the study is to increase by 15% the complete macroscopic resection rate of predominantly liver metastases from metastatic color
Irinotecan (180 mg/m²) on day 2 as a 6 hour infusion, starting at 2:00, with a peak at 5:00. Oxaliplatin (85 mg/m²) in split daily doses for 3 days, starting on day 2. Daily sinusoidal infusion duration will last from 10:15 to 21:45, with peak delivery rate at 16:00.. 5-Fluorouracil (2800 mg/m²) in split daily doses for 3 days, alternating with oxaliplatin infusions, starting on day 2. Daily sinusoidal infusions will last from 22:15 to 9:45 , with peak delivery at 4:00.. Treatments will be repeated every 2 weeks. ...
In 15 to 20% of patients, the right hepatic artery will arise from the superior mesenteric artery and travel upward toward the liver along the posterior aspect of the head of the pancreas (referred to as a replaced right hepatic artery). It is important to look for this variation on preoperative computed tomographic (CT) scans and in the operating room (OR) so the replaced hepatic artery is recognized and injury is avoided. (See Schwartz 10th ed., p. 1345.) ...
Hepatic angiography uses X-rays to check the blood vessels that supply blood to your liver. Heres what you need to know if you are having this procedure.
Semantic Scholar extracted view of [Combined treatment by hepatectomy and postoperative chemotherapy via a catheter in the hepatic artery of metastatic liver tumors]. by Shinji Yamasaki et al.
An artery that distributes blood to the liver, pancreas and gallbladder as well as to the stomach and duodenal portion of the small intestine. * * * hepatic artery n the branch of the celiac artery that supplies the liver with arterial blood
HAT is one of the most common and potentially most disastrous arterial complications (see images below). HAT is estimated to occur in 4-12% of adult OLTX patients and in 9-42% of pediatric transplanta... more
Embolization. For those who cant have surgery or a liver transplant, embolization or chemoembolization may be an option. The doctor inserts a tiny catheter into an artery in your leg and moves the catheter into the hepatic artery.. For embolization, the doctor injects tiny sponges or other particles into the catheter. The particles block the flow of blood through the artery. Depending on the type of particles used, the blockage may be temporary or permanent.. Without blood flow from the hepatic artery, the tumor dies. Although the hepatic artery is blocked, healthy liver tissue continues to receive blood from the hepatic portal vein.. For chemoembolization, the doctor injects an anticancer drug (chemotherapy) into the artery before injecting the tiny particles that block blood flow. Without blood flow, the drug stays in the liver longer.. Targeted Therapy. People with liver cancer who cant have surgery or a liver transplant may receive a drug called targeted therapy. Sorafenib (Nexavar) ...
For those who cant have surgery or a liver transplant, embolization or chemoembolization may be an option. The doctor inserts a tiny catheter into an artery in your leg and moves the catheter into the hepatic artery.. For embolization, the doctor injects tiny sponges or other particles into the catheter. The particles block the flow of blood through the artery. Depending on the type of particles used, the blockage may be temporary or permanent.. Without blood flow from the hepatic artery, the tumor dies. Although the hepatic artery is blocked, healthy liver tissue continues to receive blood from the hepatic portal vein.. For chemoembolization, the doctor injects an anticancer drug (chemotherapy) into the artery before injecting the tiny particles that block blood flow. Without blood flow, the drug stays in the liver longer.. ...
Biliary necrosis refers to the death of the intra-hepatic bile ducts epithelium commonly seen as a complication of hepatic artery thrombosis. Pathology Different from the liver parenchyma that has dual supply, portal vein and hepatic artery, t...
HCC is one of the deadliest types of cancers, with a mortality of almost 100 % [36]. The mortality of HCC remains high because the disease is typically diagnosed when it is already at an advanced stage, when most potential curative therapies such as resection and transplantation are of limited efficacy. Recent studies reported that different therapies including surgery [5-7], hepatic artery ligation [37], insufficient radiofrequency ablation [38-40], and sublethal heat treatment [41] promoted residual tumor progression. It is especially important to investigate the underlying mechanism. Our research team has developed a safe and reliable method of palliative HCC resection in an orthotopic nude mouse model, and reported that palliative resection enhances metastatic potential of residual HCC in liver [5]. In the present study, using this method, we investigated the precise mechanism mediating this metastasis.. Data from our institution (1958-2008, unpublished) revealed that in HCC patients who ...
Albert NM, Hancock K, Murray T, Karafa M, Runner JC, Fowler SB, Nadeau CA, Rice KL, Krajewski S. Cleaned, ready-to-use, reusable electrocardiographic lead wires as a source of pathogenic microorganisms. Am J Crit Care. 2010 Nov;19(6):e73-e80.. Alberts SR, Roh MS, Mahoney MR, OConnell MJ, Nagorney DM, Wagman L, Smyrk TC, Weiland TL, Lai LL, Schwarz RE, Molina R, Dentchev T, Bolton JS. Alternating systemic and hepatic artery infusion therapy for resected liver metastases from colorectal cancer: a North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) phase II intergroup trial, N9945/CI-66. J Clin Oncol. 2010 Feb 10;28(5):853-858.. Anderson HV, Rosenfield KA, White CJ, Ho KK, Spertus JA, Jones PG, Tang F, Cates CU, Jaff MR, Koroshetz WJ, Katzan IL, Hopkins LN, Rumsfeld JS, Brindis RG. Clinical features and outcomes of carotid artery stenting by clinical expert consensus criteria: a report from the CARE registry. Catheter Cardiovasc Interv. 2010 ...
Primary liver cell carcinoma is often difficult to diagnose, and the efficacy of celiac arteriography in demonstrating this tumor has been evaluated. Selective catheterization and injection of the celiac axis and hepatic artery was performed, with utilization of a serial magnification technic allowing definition of fine vessels. Characteristic vascular changes were found in nine patients, and the presence of hepatoma was confirmed histologically.. Hepatoma is a vascular tumor and is recognized by abnormal tumor vessels that exhibit a disorganized and chaotic pattern. The hepatic artery supplying the tumor is usually wider than normal, and the intrahepatic branches are displaced. Marked ...
The SIRT procedure delivers radiation to the liver in minuscule spheres about the size of a speck of flour. The spheres, which contain radioactive yttrium-90, are injected into the main hepatic artery and delivered directly to the cancer tumor. Since healthy liver tissue draws most of its blood from the portal vein, the spheres delivered through the hepatic artery target the cancerous tumor growth in the liver. These spheres are just large enough to get stuck in the blood vessels of the tumor and directly irradiate it. This ability to direct the radiation limits the amount of radiation that reaches healthy liver tissue and other parts of the body. To determine the amount of radioactive spheres that will reach the tumor, radiologists inject a similar solution of radioactive particles that allows them to view a snapshot of the particle distribution, explains Ronald Weiner, a radiopharmacist and associate professor of diagnostic imaging at the Health Center. We can see how much of the ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of "NTU Repository" with "Academic Hub" to form NTU Scholars.. ...
The liver is a common site of metastases from a variety of organs such as lung, breast, colon and rectum. When liver metastases occur at the time of initial diagnosis of the primary tumor, they are described as synchronous. If detected after the initial diagnosis, they are described as metachronous. The liver is frequently involved since it receives blood from the abdominal organs via the portal vein. Malignant cells detach from the primary cancer, enter the bloodstream or lymphatic channels, travel to the liver, and grow independently. We do not understand the mechanism of how a tumor cell can leave the primary site and grow in specific organs. Potentially, the environment of the liver is suitable to the growth of certain tumor cells. Once a tumor begins to grow in the liver, it receives its blood supply from the hepatic artery ...
SDBPs theoretically must bind to DNA to exhibit their dysopsonin activity. However, when DNA is directly injected into the bloodstream, SDBPs do not have enough time to bind the DNA because the DNA will be quickly taken up by the liver and eliminated from blood. Presumably, if the binding condition is provided for SDBPs, their in vivo dysopsonin activity should be observed. We, therefore, designed in vivo studies to confirm the activity of serum diminishing liver uptake of DNA. The first study was to preincubate DNA with serum before the injection. Compared with a control, the DNA preincubated with serum (SDBPs/DNA) had a decrease in percentage taken up by the liver and an increase of percentage in the blood. The second study was to provide a retention time for SDBPs binding the injected DNA (see Materials and Methods), in which the DNA, after the injection, was allowed to circulate in blood for a few minutes but was not passed through the liver. By blocking the hepatic artery and portal vein, ...
Saad, WEA; Davies, MG; Saad, NEA; Westesson, KE; Patel, NC; Sahler, LG; Lee, DE; Kitanosono, T.; Sasson, T.; Waldman, DL. "Trans-Catheter Thrombolysis of Thrombosed Hepatic Arteries in Liver Transplant Recipients: Predictors of Definitive Endoluminal Success and the Role of Pre-Operative Thrombolysis." Vasc Endovasc Surg. 2007; 41(2).. 9/2006 ...
CYP3A5, a member of the cytochrome P450 superfamily of enzymes, is involved in the metabolism of drugs, exogenous carcinogens, and endogenous molecules such as steroids (20). Previous studies about CYP3A5 have mainly focused on two major aspects, the potential relationship of CYP3A5 polymorphism and cancer risk or drug metabolism (9-11, 21-26). Moreover, Tsunedomi R concluded that the expression of CYP3A5 was drastically decreased in conjunction with venous invasion and might serve as a marker of progression and molecular target for treatment of HCV-associated HCC (27). Similar findings were also reported in some earlier articles (28, 29). Importantly, the expression of CYP3A5 was declined from early to late hepatic cirrhosis. In our current study, CYP3A5 expression was found frequently downregulated in tumor tissues and was negatively associated with several malignant characteristics and poor prognosis in patients with HCC. Ectopic expression of CYP3A5 attenuated cell migration, invasion, and ...
hepatic - MedHelps hepatic Center for Information, Symptoms, Resources, Treatments and Tools for hepatic. Find hepatic information, treatments for hepatic and hepatic symptoms.
Figure 5. Advantages and Disadvantages. Advantages of the technique can be resumed as follows:. 1) Avoiding the immediate tying of the running suture at several mucopexy sites allows a better identification of the major arterial branches, since the distance between the Doppler probe and the artery is represented only by the thickness of the rectal mucosa which is not folded in multiple layers (Fig. 3 a, b). This is true for the initial identification of the arteries at the main points of dearterialization (1,3,5,7,9 and 11 oclock) as for any vessel residual to the major branch dearterialization that should be localised and sutured, if present.. 2) The six mucosal-submucosal running sutures starting from the upper "z" stitch toward 1 cm from the dentate line are easier to place since there is no mucosal folding between the threads, resulting in a more straight mucopexy with no risk of over-suturing and with an easier identification of the rectal mucosa.. 3) The avoidance of mucosal "pocket" ...
Hemorrhoids are normal vascular cushions found in the anal canal. 15% of a humans continence mechanism is attributed to the hemorrhoidal plexus. When a person coughs, for instance, the hemorrhoids will engorge with blood and increase ones ability to hold gas and stool. They are termed internal and external based on their positioning to an embryological line termed the pectinate line. Hemorrhoids above the pectinate line are considered "internal" and those below it "external".[2] Hemorrhoids are fed by arteries and drained by veins. The arterial blood supply is based on the superior rectal (hemorrhoidal) artery. Just as veins in the leg weaken and become prominent, hemorrhoidal veins also may become varicose, resulting in internal hemorrhoids or "piles". Internal hemorrhoids are divided into four grades. Grade I hemorrhoids are composed of prominent vessels, without protrusion. Grade II hemorrhoids demonstrate prolapse upon straining, with spontaneous reduction. Grade III hemorrhoids ...
HEPATIC ARTERY STENOSIS IN ORTHOTOPIC LIVER TRANSPLANTATION (LTX): SINGLE CENTER EXPERIENCE IN A SERIES OF 527 PATIENTS. . Hepatic artery complications after liver transplantation are uncommon- improved techniques.However, they represent an important cause of morbidity and mortality and are a m...
TY - JOUR. T1 - Intrahepatic biliary strictures without hepatic artery thrombosis after liver transplantation. T2 - An analysis of 1,113 liver transplantations at a single center. AU - Nakamura, Noboru. AU - Nishida, Seigo. AU - Neff, Guy R.. AU - Vaidya, Anil. AU - Levi, David M.. AU - Kato, Tomoaki. AU - Ruiz, Phillip. AU - Tzakis, Andreas G.. AU - Madariaga, Juan R.. PY - 2005/2/27. Y1 - 2005/2/27. N2 - Background. Intrahepatic biliary strictures (IHBS) without hepatic artery thrombosis (HAT) is a serious complication and known to increase the risk of graft failure after liver transplantation. This manuscript describes the incidence, risk factors, clinical pictures, management, and outcomes. Methods. Between 1994 and 2002, 1,113 liver transplantations were performed in 974 adult patients. Data was retrospectively analyzed in terms of incidence, risk factors, clinical pictures (type of strictures), management (radiologic, surgical management), and outcomes. Results. Sixteen (1.4%) grafts had ...
TY - JOUR. T1 - Hepatic artery aneurysm within focal nodular hyperplasia. AU - Schlieman, Michael. AU - Stein, Moni. AU - McVicar, John. AU - Bold, Richard J. PY - 2002. Y1 - 2002. UR - http://www.scopus.com/inward/record.url?scp=0036171679&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0036171679&partnerID=8YFLogxK. U2 - 10.1016/S0168-8278(01)00247-1. DO - 10.1016/S0168-8278(01)00247-1. M3 - Article. C2 - 11830345. AN - SCOPUS:0036171679. VL - 36. SP - 302. JO - Journal of Hepatology. JF - Journal of Hepatology. SN - 0168-8278. IS - 2. ER - ...
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Embolization is done in stages (usually 2 treatments several weeks apart) if there is bilobar disease. Many patients experience a post-embolization syndrome that includes abdominal pain, fever, nausea, and ileus. Hepatic enzymes are often elevated transiently. Rarely, cholecystitis or pancreatitis occurs due to inadvertent embolization of the cystic or gastroduodenal arteries. The most feared complications of HAE are liver abscess and liver necrosis, which are rare. Most patients are discharged from the hospital within 3-5 days. The procedure may be repeated several times over the course of months to years.. There are only a few reported series of HAE for metastatic GIST. In one report, 14 patients with intestinal leiomyosarcoma (presumably most of which were GIST) metastatic to the liver were embolized in either the left or right hepatic artery with polyvinyl alcohol sponge particles mixed with cisplatin. Then, a 2 hour intraarterial infusion of vinblastine was administered.1 One month later, ...
We investigate the efficacy of lipiodol+degradable starch microspheres (DSM)-transarterial infusion chemotherapy (TAI) using miriplatin for advanced HCC in a
The combination of hepatic artery infusion (HAI) of irinotecan, 5-fluorouracil and oxaliplatin with intravenous cetuximab has safely achieved prolonged survival in colorectal cancer patients with extensive liver metastases and prior treatment. Systemic exposure to the drugs or their main metabolites was determined during the first course of chronomodulated triplet HAI in 11 patients and related to toxicities after one or three courses. Consistent trends were found between the area under the plasma concentration-time curve (AUC) values of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN38; a bioactive metabolite), total oxaliplatin and platinum ultrafiltrate (P-UF), on the one hand, and subsequent leukopenia severity, on the other hand. Moreover, the maximum plasma concentration (C max) and the AUC of P-UF significantly predicted grades of diarrhoea (p = 0.004 and 0.017, respectively) and anaemia (p = 0.001 and 0.008, respectively) after the first course. Systemic drug exposure helps explain both ...
Background Whether hepatic arterial infusion (HAI) of oxaliplatin influences the rates of complete pathologic response (CPR) and severe oxaliplatin-related lesions (SOxL) in patients with colorectal...
The aim of this study is to evaluate the effectiveness of 111In-DTPA-Phe1-octreotide infusions after selective catheterization of the hepatic artery in inoperable metastasised liver, sst2 receptor-pos
This phase II trial compared the efficacy of postoperative adjuvant hepatic arterial infusion of fluorouracil with or without antineoplaston A10 +
Moreno, C., Sabaté, A., Figueras, J., Camprubí, I., Dalmau, A., Fabregat, J., Koo, M., Ramos, E., Lladó, L. and Rafecas, A. (2006), Hemodynamic profile and tissular oxygenation in orthotopic liver transplantation: Influence of hepatic artery or portal vein revascularization of the graft. Liver Transpl, 12: 1607-1614. doi: 10.1002/lt.20794 ...
Evidence-based recommendations on chemosaturation via percutaneous hepatic artery perfusion and hepatic vein isolation for primary or metastatic liver cancer
2 of 2) The hepatoduodenal ligament contains the proper hepatic artery, common bile duct, and portal vein. These three structures collectively are also known as the portal triad. These structures will be cleaned and identified later.. Links and References: ...
Although flow through portal vein and hepatic artery is readily accessible using Doppler sonography, (22,23) in vivo studies on human hepatic (parenchymal) perfusion are limited due to the often (highly) invasive methodology required. Indirect methods for measuring hepatic blood flow have been used and include the assessment of clearance or dilution of a dye or marker (gas or microspheres), which have a wider range of clinical applicability than the direct methods (38). Moreover, noninvasive measurements of hepatic perfusion using PET with the freely diffusible flow tracer [15O]H2O have been shown to provide reliable estimates of hepatic blood flow, when taking into account the dual input from hepatic artery and vena porta (27,28). In the current study, decreased hepatic parenchymal perfusion was observed in type 2 diabetic patients with increased liver triglyceride content but not in those type 2 diabetic patients with low liver triglyceride content, as compared with control subjects, implying ...
Arterial Chemotherapy is designed to improve chemotherapy benefits for liver cancer by increasing the amount of chemotherapy delivered to the site of the tumor.
Failed Allografts. The reasons for liver allograft failure vary with the time since transplantation(1-6). Primary dysfunction because of ischemic/preservation injury and hepatic artery thrombosis and subsequent bile duct necrosis are the most common causes of liver within the first several weeks. Humoral and severe acute cellular rejection also occur during this time, but they are uncommon causes of early allograft failure. Frequently, a combination of the above factors ultimately contribute to deterioration of graft function(1-6). Between 2-3 weeks and 6 months after transplantation, delayed complications of early technical problems, such as the biliary sludge syndrome from ischemic cholangitis(7, 8), acute rejection and rapidly developing cases of chronic rejection(9, 10) are the major causes of graft failure. There are still graft failures that occur more than 6 months after transplantation, as a result of delayed technical complications. These usually involve the hepatic artery and ...
Purpose Hepatic metastases derive most of their blood supply from the hepatic artery; therefore, for patients with hepatic metastases from colorectal cancer, hepatic arterial infusion (HAI) of chemotherapy may improve outcome. Methods In a multi-institutional trial, 135 patients were randomly assigned to receive HAI versus systemic bolus fluorouracil and leucovorin. The primary end point was survival; secondary end points were response, recurrence, toxicity, quality of life, cost, and the influence of molecular markers. Results Overall survival was significantly longer for HAI versus systemic treatment (median, 24.4 v 20 months; P = .0034), as were response rates (47% and 24%; P = .012) and time to hepatic progression (THP; 9.8 v 7.3 months; P = .034). Time to extrahepatic progression (7.7 v 14.8 months; P = .029) was significantly shorter in the HAI group. Quality-of-life measurements showed improved physical functioning in the HAI group at the 3- and 6-month follow-up assessments. Toxicity ...
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There are several treatment options for GIST liver metastases. The first choice is Imatinib therapy. Other options that may be useful in combination with Imatinib, or if the tumor is resistant to imatinib or other agents,include: radiofrequency ablation (RFA), hepatic artery embolization, and surgery. RFA is the insertion of a metal probe into a tumor in order to heat it and thereby kill it. RFA can be performed through the skin with the patient slightly sedated or during laparoscopy or open operation. We usually only use RFA when there are less than 6 tumors, the tumors are less than 5 cm in size, and the tumors are not near vital structures within the liver.. Embolization is a procedure performed by an interventional radiologist. A small tube is placed into the artery in your leg and fed upwards into the artery supplying your liver. Microscopic particles are then injected into the tumors to try to cut off their blood supply. Liver resection (surgery) is another option. In general, up to 80% of ...
OBJECTIVE: To investigate whether the selective iNOS-inhibition using 1400W is able to attenuate the decrease of excretory liver function in a clinically relevant model of long-term, hyperdynamic porcine endotoxemia. DESIGN AND SETTING: Prospective experimental study in the animal laboratory in a university hospital. SUBJECTS: twenty-one domestic pigs. INTERVENTIONS: Pigs were anaesthetized, mechanically ventilated, and instrumented. After 12 h of continuous i.v. endotoxin (LPS) infusion pigs received either no drug (ETX, n = 12) or 1400W, titrated to maintain mean arterial pressure (MAP) at pre-endotoxin level (n = 9). Measurements were obtained before, 12 h and 24 h after starting LPS infusion. MEASUREMENTS AND RESULTS: Excretory liver function was assessed by quantitative bile excretion, biliary ICG excretion, biliary HCO3 excretion and PDR of ICG. Our measurements included also the portal venous and hepatic arterial blood flow, the regional O2-exchange and the expiratory NO amount. Despite ...
Dear Editor,. We report the case of a 47-year-old male with multiple myeloma who had received three previous hematopoietic cell transplants (HCT). Due to disease recurrence, a new HCT was performed after an appropriate conditioning therapy. Two days later he presented with ascites, jaundice and hepatomegaly. The ultrasound findings were hepatosplenomegaly and moderate ascites. Doppler examination showed signs of hepatic congestion with a slower portal flow, increased resistance in the hepatic artery (Fig. 1) and decreased liver compliance with a single-phase wave of the suprahepatic veins. The diagnosis was confirmed by a transjugular liver biopsy that showed extravasation of red blood cells, edema and subendothelial fibrosis in the centrolobuliary veins. Treatment with defibrotide was initiated and the patient improved on a clinical and analytical level. Hepatic vascularization and perfusion also improved, the portal vein exhibited a normal diameter, and velocity and flow and the hepatic artery ...
Since the portal vein brings much more blood to the liver than does the hepatic artery, each branch of the portal vein is typically much larger than the associated branch of the hepatic artery. The relative sizes of the paired vessels in a portal area thus differ from those of a typical vein / artery pair in other parts of the body, where the artery delivers the same volume of blood that the vein subsequently returns. ...
taken care by these plates and plays a vital role in formation of the lobules in liver. Within each lobule a central vein pass by. The peripheral edge of each lobule comprises of a branch of hepatic Portal vein and hepatic artery. This results in a wide space between each and every hepatic plate. The GI tract serves the function of absorption and the process is hosted by the portal venous blood ...
Liver triad. Fluorescence deconvolution micrograph of a section through liver tissue, showing a portal triad. This is a collection of vessels that includes the hepatic artery and bile duct (small vessels, upper right) and the much larger hepatic portal vein (diagonal, black). Cellular proteins are highlighted with fluorescent markers: g-actin (red), f-actin (green), and cell nuclei (blue). Magnification: x200 when printed at 10 centimetres across. - Stock Image C019/7830
comes in contact with the blood. The structuring aspect is taken care by these plates and plays a vital role in formation of the lobules in liver. Within each lobule a central vein pass by. The peripheral edge of each lobule comprises of a branch of hepatic portal vein and hepatic artery. This results in a wide space between each and every hepatic plate. The GI tract serves the function of ...
In order to find the most effective hepatitis treatment you will need to mention that different viruses impact the liver diversely. To be aware of the way the virus is transmitted we must mention first how a liver works. The liver may be the largest body organ that weights about 3 pounds, and is also the central spot for many body functions. It is located in the upper right side from the abdomen beneath the cover of the ribs and is also comprised of many hexagonal structures called liver lobules. The liver creates the bile that stops working fat in foods and receives blood from two sources: from your portal vein, which comes in the intestine loaded with nutrients for that liver to process; and one-third through the hepatic artery. The liver converts food into energy; stores nutrients, fat and vitamins; makes proteins for blood plasma; and detoxifies the body. Her largest and a lot complex bloody availability of any organ in the body. We have an artery to provide it with oxygenated blood and ...
The spleen is located under the left side of the diaphragm and near the stomach, pancreas, liver and the heart. The inferior vena cava and the hepatic artery, coming from the heart, are located to...
INDICAŢIILE OLT După Registrul American de transplant hepatic: 1.CH postvirusală C 2.CH alcoolică 3.CH criptogenetică 4.CBP 5.Isuficienţa hepatică acută 6.CH autoimună 7.CH mixtă alcoolică şi postvirusală 8.Colangita sclerozantă
ŞANDRU, S.; BALTAGA, R.; BELÎI, A.; COBÂLEŢCHI, S.; GUZUN, N.; ROJNOVEANU, Gh. Managementul anestezic la pacienţii cu traumă hepatică. În: Săndesc D., Bedreag O., Păpurică M. Recomandări şi protocoale în anestezie. Terapie intensivă şi medicină de urgenţă, Timişoara, 2012, p.169-181. ISBN 978-973-52-1260- ...
We invest our time and $20,000 in 20 healthcare IT companies annually. Blueprint Health workers and mentors work intensively with the companies for 3 months to help them meet their particular person business objectives. Usually these goals embody gaining customers, raising capital, constructing advertising and gross sales collateral, and refining an investor pitch. Fantastic, informative lens, made extra wonderful as a result of its your private experience. Thank you! Best to have him test with the employees or his physician and signal the paperwork if he needs a assure release, (if hes steady and secure), OR, wait to see if his doc will discharge him the subsequent day, again, depending on his circumstances and endangerment.. So the bottom line appears to be that for health care organizations, generating conflicts of interest affecting political leaders, and shopping for political influence is unacceptable - if the political leaders are Nazi, Ku Klux Klan, or white supremicist sympathizers. ...
Title:Glutathione for Hepatotoxicity in Patients with Liver Cirrhosis and Advanced Hepatocellular Carcinoma Receiving Hepatic Arterial Infusion Chemotherapy. VOLUME: 2 ISSUE: 1. Author(s):Koichi Momiyama, Hidenari Nagai, Yu Ogino, Takanori Mukozu, Daigo Matsui, Teppei Matsui, Noritaka Wakui, Mie Shinohara, Yoshinori Igarashi and Yasukiyo Sumino. Affiliation:Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, 6-11-1, Omorinishi, Otaku, Tokyo, Japan, 143-8541.. Keywords:5-FU, HCC, hepatic arterial infusion chemotherapy, hepatotoxicity, liver fibrosis, glutathione, 7S domain of type IV collagen, hyaluronic acid, N-terminal propeptide of type III procollagen.. Abstract:Purpose: We have previously reported that hepatic arterial infusion chemotherapy (HAIC) prolongs the survival of patients with advanced hepatocellular carcinoma (aHCC). However, 5- fluorouracil (5-FU) has been found to exacerbate liver damage ...
Arterial supply to the pancreas is from branches of the celiac artery and SMA, which converge via the superior and inferior pancreaticoduodenal arteries. The celiac axis arises from the abdominal aorta and most commonly gives rise to the splenic artery, the left gastric artery, and the common hepatic artery. The splenic artery courses along the posterior surface of the pancreatic body and tail and gives rise to branches that supply the pancreatic body and tail. The gastroduodenal artery (GDA) is the first branch off the common hepatic artery. Distal to the first portion of the duodenum, the GDA becomes the superior pancreaticoduodenal artery, which divides into anterior and posterior branches. ...
TY - JOUR. T1 - Can selective CT angiography reduce the incidence of severe complications during transcatheter arterial embolization or infusion chemotherapy for thoracic diseases?. AU - Tanaka, Osamu. AU - Hashimoto, Subaru. AU - Narimatsu, Yoshiaki. AU - Fujiwara, Hirokazu. AU - Kurata, Tadayoshi. AU - Okuda, Shigeo. AU - Yamagami, Takuji. AU - Nishimura, Tsunehiko. AU - Hiramatsu, Kyoichi. AU - Kuribayashi, Sachio. PY - 2006/12/1. Y1 - 2006/12/1. N2 - Purpose: To evaluate the usefulness of selective computed tomography (CT) angiography in preventing severe complications, such as spinal cord injury and broncho-esophageal fistula, during the transcatheter arterial embolization or infusion chemotherapy for thoracic diseases. Materials and methods: Data from 28 patients with thoracic diseases were retrospectively analyzed in terms of selective CT angiography procedures carried out before transcatheter arterial embolization or transcatheter arterial infusion chemotherapy. Results: There were no ...
The liver possesses a dual blood supply from the hepatic portal vein and hepatic arteries. The hepatic portal vein supplies approximately 75% of the livers blood flow, and the hepatic artery accounts for the remainder. Moreover, the liver is the dominant organ for congregation of contrast agent. After intravenous bolus injection, contrast agent transported via hepatic artery arrives 20-30 seconds earlier to the liver than if transported via portal vein, and this differential explains the difference seen between HAP and PVP imaging. Studies have confirmed that utilizing both PVP and HAP CTs elevates the rates of detection [9, 10]. Therefore, the PVP and HAP CTs are often applied during the simulation stage of liver cancer radiotherapy treatment. Hounsfield units represent a tissues electron density via x-ray attenuation, and as such, are a critical and contributory component of dose calculation in the planning system. In this study, we found that the HUs of the GTV and liver in both PVP and HAP ...
Ms j is prescribed case study iii.1 case study. If from the spinous process pedicle c6 vertebra to the left main bronchus. In this study, human mesenchymal stem cells promote neuronal cell differentiation from neuronal progenitor cells and eosinophils. Treatment of super cial mycoses, regular exercise and taking great pains to avoid those triggers as well as in pulmonary embolism. Cancer cell 4:509 501 regulator and potential downstream harms. Be fatal, even if one partner is another name attached to the abdominal wall. Chromosome the gonad to the uterus, especially the skull; and the assistant port is placed in the t thyroid gland that weighs about 20 per drugs include headache, rash, gastro- and mineralocorticoids, including uid intake and oral contraceptives, with high or low occupational status [67]. The proper hepatic artery stomach transverse colon inferior hypogastric plexus right and left subclavian veins) (fig, however. National alliance on mental health being able to swallow the ...
THD interrupts blood circulation by ligating the hemorrhoidal artery in the lower rectum. The artery is located using Doppler equipment. Interrupting blood circulation to the hemorrhoidal artery contributes to shrinkage of the hemorrhoidal cushion and subsequently improves symptoms. Because the ligation is conducted above the dentate line, the pain-sensitive anoderm is preserved. Elmer and colleagues (2013) compared the early and midterm results of THD with anopexy to open hemorrhoidectomy. A total of 40 participants with grade II to grade III hemorrhoids were randomized to THD with anopexy (group A, n=20) or open hemorrhoidectomy (group B, n=20). Participants kept a diary during the first 2 postoperative weeks to record pain scores. A self-reported symptom questionnaire was completed, and a clinical examination was performed preoperatively, after 2 to 4 months, and after 1 year. Postoperative pain was the primary outcome measure. During the first week, group A had less postoperative peak pain ...
Author: KRISHNAMURTHY JWALA VENKATA , R. KALPANA, J. SRIVANI. Category: Anatomy. [Download PDF]. Abstract:. During routine dissection of the abdomen of a 60- year- old male cadaver at Anatomy Department, several vascular and visceral variations were observed . An accessory hepatic artery arose from common hepatic artery, proximal to gastroduodenal artery and supplied the left lobe of liver. The left gastric vein joined the dorsal pancreatic vein and opened into splenic vein . The portal vein formation was normal and it received inferior mesenteric vein at the junction between splenic and superior mesenteric veins. Visceral variations: The epiploic foramen was closed with fibrous adhesions. The greater omentum was attached to the visceral surface of the spleen. The appendix was very short in length and was in splenic position . The mucosa of the cecum and descending colon showed irregular growths. There was a matted lymph node mass in the para-vertebral gutter above the first part of the duodenum ...
CT Abdomen with contrast. A: Computed tomography (CT) during hepatic artery phase reveals contrast in aorta and right anterior portal vein (arrow). B: Maximum intensity projection also during hepatic artery phase shows hepatic artery (arrowhead) and right portal vein branches (arrow). (Source: Gallego C, Velasco M, Marcuello P, Tejedor D, De Campo L, Friera A. Congenital and acquired anomalies of the portal venous system. RadioGraphics 2002;22:141-159, with permission from the Radiological Society ...
The purpose of this study is to determine whether the addition of bevacizumab, to hepatic arterial therapy with floxuridine (FUDR) and dexamethasone (De
As the right gastric artery is not the major contributor to the gastric bed, it is one that is often overlooked in literature relating to arterial variation. It is a highly variable artery; with studies showing it can arise from the hepatic artery proper (HAP), gastro duodenal artery (GDA) and the left, right, common or middle hepatic arteries [8,9,10]. Identification of the right gastric artery is critical, for interventional radiologists, since inadvertent chemotherapy delivery to this artery can result in significant gastric mucosal damage (necrosis, ulceration or perforation) [6,9]. Evidence shows that the correct identification and embolisation of the right gastric artery can reduce the incidence of these complications from 36% to 3% [11].. Selective internal radiotherapy (SIRT). SIRT initially gained approval in 2002 by the United States Food and Drug Administration (USFDA) for the treatment of hepatic metastases secondary to colorectal adenocarcinoma [12]. Access to the hepatic ...
The SIRT procedure enables radiation to be targeted directly into the liver tumours by using the tumours own blood supply. Healthy liver tissue derives up to 90% of its blood supply from the portal vein (the vein that delivers nutrients to the liver from the gut), with only a small amount of the blood supply being derived from the hepatic artery. In contrast, liver tumours derive up to 90% of their blood supply from the hepatic artery, since they need a profuse supply of highly oxygenated blood. The hepatic artery therefore provides an ideal route to deliver targeted treatment to liver tumours.. SIR-Spheres Y-90 resin microspheres have an average diameter of 32.5 microns (range between 20 and 60 microns) which means that following infusion, they are small enough to become lodged in the arterioles within the growing rim of the tumour(s) where they emit a high dose of radiation, but are too large to pass through the capillaries and into the venous system. As SIR-Spheres Y-90 resin microspheres ...
Principal Investigator:OKUNO Kiyotaka, Project Period (FY):1994 - 1996, Research Category:Grant-in-Aid for Scientific Research (B), Section:一般, Research Field:Digestive surgery
PurposeThe aim of the present study was to investigate the technical feasibility of flat-panel cone-beam CT (CBCT)-guided radiofrequency ablation (RFA) of very small (,1.5 cm) liver tumors.Materials and MethodsPatients included were candidates for hepatic percutaneous RFA as they had single biopsy-proven hepatic tumors sized ≤1.5 cm and poorly defined on ultrasonography. Following apnea induction, unenhanced CBCT scans were acquired and used to deploy the RF electrode with the aid of a virtual navigation system. If the tumor was not clearly identified on the unenhanced CBCT scan, a right retrograde arterial femoral access was established to carry out hepatic angiography and localize the tumor. Patients lesions and procedural variables were recorded and analyzed.ResultsThree patients (2 male and 1 female), aged 68, 76, and 87 years were included; 3 lesions (2 hepato-cellular carcinoma and 1 metastasis from colorectal cancer) were treated. One patient required hepatic angiography. Cycles of ...
Featured Article: Phase II Trial of Hepatic Artery Infusional and Systemic Chemotherapy for Patients With Unresectable Hepatic Metastases From Colorectal Cancer: Conversion to Resection and Long-term Outcomes. Dangelica MI, Correa-Gallego C, Paty PB, et al. Ann Surg. 2014 Mar 21. [Epub ahead of print]. Summary: The rate of conversion of unresectable colorectal liver metastases (CRLM) to resectable CRLM has improved with modern systemic chemotherapy and biologic therapy. Results of recent studies, including randomized trials, report conversion rates of 20-38%. The combination of hepatic artery infusional (HAI) chemotherapy with systemic chemotherapy has become an attractive option for the treatment of unresectable CRLM owing to the high response rates observed in previous published studies.. This prospective phase II trial aimed to evaluate, as a primary endpoint, the conversion rate to complete resection (resectability rate) in patients with unresectable CRLM treated with HAI fluorodeoxyuridine ...
BACKGROUND: Endovascular management is the mainstay of therapy for most patients with primary and secondary liver tumors. Radiologist should understand the anatomy of the hepatic vasculature and tumor feeding vessels to ensure successful conduction of the embolization procedure. The aim of this study was to evaluate the accuracy of multidetector computed tomographic angiography (MDCTA) for the evaluation of hepatic arterial anatomy and tumor feeding vessels prior to embolization procedure ...
Research should document indications for treatment, details of patient selection and details of adjuvant and prior treatments. Outcome measures should include complications, survival and quality of life. Data from welldesigned trials comparing the procedure against other forms of management would be particularly useful, but prospective observational studies may also be of value ...
Study population. The study population consisted of patients with histologically confirmed metastatic carcinoid tumor. Other neuroendocrine neoplasms were excluded. Prior therapies, including chemotherapy, immunotherapy, somatostatin analogues, hepatic artery embolization, radiofrequency ablation, and cryoablation, were allowed provided measurable disease remained. Further eligibility criteria included performance status of ≤2 on the Zubrod scale, absolute granulocyte count ,1,500/mm3, hemoglobin ,8 g/dL, platelet count ,100,000/mm3, serum bilirubin ,1.5 times the upper limit of the laboratory normal, serum creatinine ≤1.5 mg/dL, and aspartate aminotransferase and alanine aminotransferase ≤2.5 times the upper limit of the laboratory reference range. Patients with clinically apparent brain metastases and pregnant or lactating women were excluded. Concurrent use of octreotide was allowed.. This study was approved by the Institutional Review Board of M.D. Anderson Cancer Center. All patients ...
TY - JOUR. T1 - Mechanisms of action and modulation of fluorouracil. AU - Grem, J. L.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Fluorouracil (5-FU) and 5-fluoro-2-deoxyuridine (FdUrd) are commercially available fluorinated pyrimidine analogues. 5-FU has antitumor activity against adenocarcinomas arising in the breast, gastrointestinal tract, and ovary, and against squamous cell carcinomas arising in the head, neck, and esophagus, with single-agent response rates of 10% to 30%. FdUrd has mainly been used for hepatic arterial infusions for patients with isolated hepatic metastases, with response rates of 42% to 62% as first-line therapy for colorectal cancer patients and 30% in those failing prior systemic 5-FU-based therapy. An appreciation for the factors influencing the cellular pharmacology of 5-FU has generated interest in combining it with both modulatory agents that enhance its metabolism or cytotoxic effects and other antineoplastic agents or modalities, such as cisplatin, methotrexate, and ...
To find the very best hepatitis treatment it is important to mention that different viruses get a new liver differently. To comprehend the way the virus is transmitted we need to mention first how the liver works. The liver is the largest body organ that weights about 3 pounds, and is also the central spot for many body functions. It can be perfectly located at the upper right side from the abdomen beneath the cover with the ribs and is made up of many hexagonal structures called liver lobules. The liver creates the bile that reduces fat in foods and receives blood from two sources: in the portal vein, links through the intestine full of nutrients to the liver to process; and one-third from your hepatic artery. The liver converts food into energy; stores nutrients, fat and vitamins; makes proteins for blood plasma; and detoxifies your body. The nations largest and quite a few complex bloody availability of any body organ. Theres an artery to produce it with oxygenated blood and hepatic veins ...
Chemotherapy. These are medicines that kill cancer cells. They may be given before or after surgery. They are delivered into a vein (IV) or by shot (injection), or by mouth (oral). The medicines may also be delivered to the liver. This is done with a tube (catheter) into the livers main artery. This is called chemoembolization of hepatic artery. The medicine is mixed with a substance that blocks the flow of blood to the tumor. This causes problems with the tumors growth ...
The liver is the second largest (after skin) single organ in the body,weighing 2 kg in the average adult.. As adult humans can be of different size,so can the liver.. It is approximately 21-22.5 cm across its widest point,15-17.5 cm at its greatest vertical height,and 10-12.5 cm from front to back.. The liver is composed of soft,red-brown tissue divided into lobes and enclosed by a tough fibrous capsule,and it lies in the upper abdomen on the right side,beneath and loosely attached to the diaphragm.. Its primary secretion,the bile,is poured into gallbladder and then into the duodenum (the first part of the small intestine) through the common bile duct.. In addition,it has important functions as a "ductless"gland in connection with the metabolism of carbohydrates and nitrogenous waste products.. The liver has an intricate and complex system of blood vessels. It receives its arterial supply from the hepatic artery -25% of the blood supply. There is a much larger supply of blood vessels from the ...
The liver is the second largest (after skin) single organ in the body,weighing 2 kg in the average adult.. As adult humans can be of different size,so can the liver.. It is approximately 21-22.5 cm across its widest point,15-17.5 cm at its greatest vertical height,and 10-12.5 cm from front to back.. The liver is composed of soft,red-brown tissue divided into lobes and enclosed by a tough fibrous capsule,and it lies in the upper abdomen on the right side,beneath and loosely attached to the diaphragm.. Its primary secretion,the bile,is poured into gallbladder and then into the duodenum (the first part of the small intestine) through the common bile duct.. In addition,it has important functions as a "ductless"gland in connection with the metabolism of carbohydrates and nitrogenous waste products.. The liver has an intricate and complex system of blood vessels. It receives its arterial supply from the hepatic artery -25% of the blood supply. There is a much larger supply of blood vessels from the ...
Both the metaboHsm of a material and its potential to cause toxic injury may vary with the route of exposure, although the magnitude of the dose and duration of dosing may influence this relationship. For example, materials that are metaboHcally activated by the Hver are likely to exhibit a comparatively greater degree of toxicity when given peroraHy than when absorbed in the lung or across the skin. This is largely related to the anatomical routes of transport. Thus, the greatest proportion of material absorbed from the gastrointestinal tract passes via the portal vein direcdy to the Hver. In contrast, materials absorbed as a result of respiratory exposure or skin contact initially pass to the lung and then into the systemic circulation, with only a small fraction of the cardiac output being deHvered to the Hver through the hepatic artery (Fig. 3). By similar reasoning, materials that are detoxified by the Hver may be significantly less toxic by swallowing than by either inhalation or ...
Angio graphy: celiac angiography demonstrated a large hyper-vascular tumor and dilated hepatic artery and vascular pooling in the lower lateral portion.
PMID 2180867 -- Accelerated fractionation radiation therapy for liver metastases: selection of an optimal patient population for the evaluation of late hepatic injury in RTOG studies. (1990 Leibel SA, Int J Radiat Oncol Biol Phys. 1990 Mar;18(3):523-8 ...
hepatic royal canin for sale - 2 - hepatic royal canin wholesalers & hepatic royal canin manufacturers from China manufacturers.
Hey guys! So this is a SS i got a zillion ideas for after yesterdays episode :) I wanted to put it up before todays episode because Ill lose momentum and get lost in the real happenings in the show instead of my version haha. So its basically my take on what shouldve happened with the ... | 3542078 | Qubool Hai Forum
PURPOSE: LRLT in children is a method to provide organs for transplantation. We report 2 cases of LLLS for pediatric LRLT. METHOD: Donor position: lithotomy with surgeon in French position. Trocars: three 12 mm, placed 2 cm upper the supra-umbilical mid-line and sub-costal bi-lateral on the nipple lines; one 5 mm in epigastrium. Special instrumentation: harmonic scissor, ligasure®, Hem-O-Lock clips, and Endo Catch-II® bag. Main steps: division of round, falciform, left triangular ligaments and of lesser omentum; inspection of anatomy; hepatic hilum dissection with exposure of the left hepatic artery; dissection of the right side of the falciform ligament with exposure of the left branch of the portal vein; dissection of the Arantius ligament and exposure of the left hepatic vein; parenchymal dissection with hilar plate and left biliary duct(s) section; Pfannestiel incision; placement of the graft (S2-3) into an Endo Catch-II® bag; vessels transection with endoTA; graft extraction. RESULTS: ...
Background: Treatment of metastatic colorectal cancer to the liver is not uniform. We describe the management of metastatic colorectal cancer of the liver at a single institution during a 10-year period. Methods: From January 1, 1990, through December 31, 1999, 174 patients were identified from the tumor registry at the University of Alabama at Birmingham with a diagnosis of metastatic colorectal cancer to the liver. Patient, tumor, laboratory, operative, and adjuvant therapy factors were analyzed, with overall survival as the endpoint. Log-rank tests were used for univariate analysis. Cox-proportional hazards model for multivariate analysis, and Kaplan-Meier curves were used for graphical representation of survival. Significance was defined as P<.05. Results: Median age was 60 years (age range, 18-92 years). Seventy-nine percent of patients had synchronous liver metastases at the time of diagnosis of the primary colorectal tumor. The primary tumor was in the colon and rectum 75% and 25% of the ...
Intrabiliary hydatid cysts have been known to cause complications. We report a rare case of calcified crumpled intrabiliary hydatid cyst causing massive haemobilia due to a hepatic artery pseudoaneurysm, an unusual complication of intrabiliary hydatid cyst. The patient was successfully treated by stenting of the pseudoaneurysm with overlapping stents. ...
CHICAGO-Patients lose significantly more weight after left gastric artery embolism than embolization for other gastric arteries after upper gastro intestinal (GI) bleeding, according to a study to be presented at the annual meeting of the Radiological Society of North America (RSNA).
Small for size and flow syndrome (SFSF) is one of the most challenging complications following extended hepatectomy (EH). After EH, hepatic artery flow decreases and portal vein flow increases per 100 g of remnant liver volume (RLV). This causes hypoxia followed by metabolic acidosis. A correlation between acidosis and posthepatectomy liver failure has been postulated but not studied systematically in a large animal model or clinical setting. In our study, we performed stepwise liver resections on nine pigs to defined SFSF limits as follows: step 1: segment II/III resection, step 2: segment IV resection, step 3: segment V/VIII resection (RLV: 75, 50, and 25%, respectively). Blood gas values were measured before and after each step using four catheters inserted into the carotid artery, internal jugular vein, hepatic artery, and portal vein. The pH, [Formula: see text], and base excess (BE) decreased, but [Formula: see text] values increased after 75% resection in the portal and jugular veins. EH ...
The portal vein and hepatic arteries form the livers dual blood supply. Approximately 75% of hepatic blood flow is derived from the portal vein, while the remainder is from the hepatic arteries.[2] Unlike most veins, the portal vein does not drain into the heart. Rather, it is part of a portal venous system that delivers venous blood into another capillary system, the hepatic sinusoids of the liver. In carrying venous blood from the gastrointestinal tract to the liver, the portal vein accomplishes two tasks: it supplies the liver with metabolic substrates and it ensures that substances ingested are first processed by the liver before reaching the systemic circulation. This accomplishes two things. First, possible toxins that may be ingested can be detoxified by the hepatocytes before they are released into the systemic circulation. Second, the liver is the first organ to absorb nutrients just taken in by the intestines. After draining into the liver sinusoids, blood from the liver is drained by ...
The ILO is composed by a depression located on the lower surface of the liver, which is located posterior to the square lobe and anterior caudate lobe. Receive the neurovascular bundle directly to the liver and bile ducts made up primarily of two liver from the hepatic artery, the portal vein, some lymphatic vessels and nerves that make up the hepatic nerve plexus. Each beam structure is covered by the sheath of Glisson hepatobiliary, composed of loose connective tissue, the same one that covers the surface of the faces of the liver that accompanies each pot until the penetration in one or more liver segments. In the space between a vessel and the other is the loose connective tissue support. Just before entering the liver parenchyma, bile duct branches in the duct and right hepatic duct in the left hepatic duct, which then penetrate the hilum, these bile ducts are more anterior ducts of the hepatic hilum. Posteromedial to the two hepatic ducts, starting in the two branches of the hepatic artery ...
Details of the image Subcapsular haematoma/laceration with active bleeding and embolisation Modality: DSA (angiography) (common hepatic artery)