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Patients with hemophilia who have the same level of deficient factor(s) may express different severity of clinical presentation and bleeding tendency. Therefore a test which could determine overall hemostasis rather than simple concentration of a single deficient factor may correlate better with clinical phenotype in these patients.. The investigators will therefore study the usefulness of global hemostatic methods (endogenous thrombin potential (ETP), overall hemostatic potential (OHP), fibrin clot structure) and microparticles in the prediction of severity of bleeding and estimation of response to the treatment in patients with hemophilia.. Since hemophilia patients on prophylactic treatment virtually do not bleed, additional patients who are treated on demand only will be included enabling to study possible modulatory effects of different hemostatic factors (particularly prothrombotic and thrombin activatable fibrinolysis inhibitor (TAFI)) on clinical presentation. The investigators will ...
​The Angio-Seal vascular closure device uses |strong>three bioabsorbable components |/strong>to actively seal the arteriotomy:|strong>Anchor|/strong>|br>Int
We report a case of iatrogenic claudication due to a misplaced Bay 60-7550 percutaneous arterial closure gadget (PACD) used to acquire hemostasis following cardiac catheterization. is normally estimated that occurs in half of most cardiac catheterizations. Ischemic complications as a complete result of the unit should be taken into consideration when evaluating post procedural individuals with extremity complaints. CASE Survey A 44 year-old-male with a brief history of coronary artery disease and latest cardiac catheterization provided to the crisis section complaining of correct lower extremity discomfort and numbness connected with ambulation. The symptoms began the entire time following the catheterization was performed and had progressively worsened. On display the patients essential signs were regular and he made an appearance comfortable. Study of the arterial puncture site showed a well-healing wound without appreciable mass hematoma or encircling erythema noted. Solid femoral pulses ...
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In this report, the market has been segmented based on type, access, procedures, and geographies. The type segment includes passive approximators, active approximators, and external hemostasis devices. Passive approximators are expected to account for the largest share of the vascular closure devices market in 2017. Passive approximators are the most widely used vascular closure devices in the market owing to the wide range of advantages associated with them, including increased safety and fewer complications than manual procedures.. The access segment includes femoral access and radial access. The femoral access segment is estimated to account for the largest share of the market in 2017 owing to the widespread preference for this access route among cardiologists and physicians during interventional procedures as well as the fewer complications involved during arterial access.. The procedures segment of the vascular closure devices market includes interventional cardiology and interventional ...
Most of the procedures were coronary (approximately 90%), and 50% of all the procedures were interventional. The device was successfully used 89% of the time. For ExoSeal versus manual pressure, the time to hemostasis was 4.4 minutes versus 20.1 minutes (p < 0.0001), and time to ambulation was 2.5 hours versus 6.2 hours (p = 0.0028). There were no adverse events reported in either group. Re-bleeding was 5.3% in the ExoSeal group and 2.2% in the manual compression group (p = 0.20); hematoma >6 cm was 1.9% versus 0.7% (p = 0.67).. ...
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Global Haemostasis Devices Market is expected to grow at a CAGR x.x% over the next ten years, and will reach at US$ XX.X Mn in 2029, from US$ XX.X Mn in 2019
Hemostasis is the natural process that occurs in your body to stop bleeding at the site of an injury while maintaining blood flow elsewhere in the circulation.
... Published by VPGMarketResearch.com at researchbeam.com 406 Pages
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Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Vascular Closure Devices Market research report provides granular analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Vascular Closure Devices market report 2016-2020 focuses on the major drivers and restraints for the key players. The Vascular Closure Devices market research report is a professional and in-depth study on the current state of Vascular Closure Devices Industry.. Analysts forecast the global Vascular Closure Devices market to grow at a CAGR of 8.67% during the period 2016-2020.. Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Global Vascular Closure Devices market research report @ http://www.marketreportsworld.com/10279516. The research report covers the present scenario and the growth prospects of the global Vascular Closure Devices industry for 2016-2020.. The global vascular closure devices market is likely to grow at a ...
Abbreviations: OR, odds ratio; CI, confidence interval.. Safety One of Several Benefits. "Over 95% of the elective coronary procedures in the [United States] are done using the femoral approach, with frequent use of vascular closure devices," said Dr. Weisz in an e-mail communication with TCTMD. "The results of this study confirm that in a high-volume tertiary center like Columbia University Medical Center, this approach is not inferior to the alternative approach of radial access. Furthermore, the selective use of vascular closure devices was associated with an even lower rate of vascular complications.". Robert J. Applegate, MD, of Wake Forest University School of Medicine (Winston-Salem, NC) agreed. "In low-risk patients, if your strategy is to use closure devices [this study shows that] its very effective," he told TCTMD in a telephone interview.. Dr. Applegate added that there are other benefits as well. "The patients clearly ambulate faster; they reach hemostasis faster," he said. "There ...
This is a prospective double blind randomized clinical trial of patients requiring unilateral total knee arthroplasty. The patients will be randomized intra-operatively to receiving Floseal or no treatment.. Both the patient and the observers will be blinded to whether the subject received Floseal or no treatment. Only the operating surgeons will be aware of whether Floseal or no treatment was given.. As was performed in the pilot study, randomization of Floseal or no treatment will be performed using the sealed envelope technique. Randomization will occur at the time of surgery. The statistician is responsible for maintaining the randomization schedule and issuing the sealed envelopes. The inner envelope will contain whether Floseal or no treatment is to be given on a card which will be counter-signed by the surgeon at the time of surgery. The inner envelope will then be sealed, followed by sealing of the outer envelope. Following the procedure, the surgeon will then take the sealed and signed ...
Aim of the study The aim of this study is to investigate the efficacy of hemostatic agents (HA) in Nephron Sparing Surgery (NSS). A three-matched comparison between patients treated with no HA, with Tachosil® and with Floseal® was performed. Materials and methods Observational multicentre study (RECORd Project) collects the data of 1055 patients who underwent PN between January 2009 and December 2012 at 19 Italian centres. Cases treated with more than one HA or with HA other than Floseal® or Tachosil® were excluded. A tri-match propensity score analysis was applied to create 3 groups - no HA group, Floseal® group, Tachosil® group - balanced for gender, age, surgical indication (elective/relative vs imperative), clinical stage (cT1a vs cT1b), tumour growth pattern, surgical approach (open vs minimally invasive), surgical technique (standard PN vs simple enucleation), preoperative haemoglobin and preoperative creatinine. The three groups were compared regarding the main intra and ...
INTRODUCTION & OBJECTIVES: Aim is to evaluate the efficacy of FloSeal® versus TachoSil® versus no hemostatic agents (HA) for partial nephrectomy (PN). MATERIAL & METHODS: Prospective observational multicenter study (RECORd Project) including the patients who underwent PN between January 2009 and January 2011 at 19 Italian centers. Clinical and surgical data were recorded in an on-line database and were managed by a single data-manager. The association between type of HA used and the need for blood transfusion/re-intervention and the risk of cardiovascular complications was evaluated. RESULTS: 418 patients were recruited (231 had FloSeal® PN, 116 TachoSil® PN and 71 PN without any HA - pure PN). Among the 3 groups there were no differences in the rate of suture (80.1%, 83.6% and 74.6%, respectively) or coagulation of the tumor bed (17.7%, 21.6%, 23.9%). Postoperative bleeding requiring blood transfusion/reintervention took place in 9.3%, 7.9% and 15.7% of FloSeal®, TachoSil® and pure PN, ...
The Glissonean pedicle transection method has been reported to shorten operation time, reduce intraoperative blood loss, and minimize surgical risks in HCC patients undergoing hepatectomy 22. The Glissonean approach may therefore be more beneficial for HCC patients undergoing curative resection than other hilar vascular control methods such as the Pringle maneuver. However, in a large series, only 17.1% of patients underwent major hepatectomy involving two or more segments, with most patients (80.3%) undergoing segmentectomy or subsegmentectomy18. Our patient cohort differs in the extent of liver resection as well as including only patients with large (, 5 cm) nodular HCCs. 56% Of the 25 patients in our Glissonean group, 14 (56%) underwent removal of more than 2.5 segments (right trisegmetectomy).. To our best knowledge, our study is the first to compare the surgical effectiveness and safety of Glissonean transection with the Pringle maneuver in patients with large HCC undergoing radical ...
Liver diseases are known to affect the function of remote organs. The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. Sham-operated animals underwent laparotomy only. After 15 min or 8 h of reperfusion, a single 25-mg/kg dose of FL was injected intravenously and serial (0-30 min) blood and bile and terminal brain samples were collected. Total and free (ultrafiltration) plasma, total brain homogenate, and bile concentrations of FL and/or its glucuronidated metabolite (FL-Glu) were determined by HPLC. Both IR and HxIR caused significant reductions in the biliary excretions of FL and FL-Glu, resulting in significant increases
Vascular Closure Device (VCD) Market Size & Forecast By Product (Active Approximators, Suture-Based Devices, Clip-Based Devices, Passive Approximators, Collagen Plugs, Sealant/Gel-Based Devices, Compression-Assist Devices, External - Market research report and industry analysis - 10487708
Since fibrinogen plays a key role in hemostasis and it is rapidly depleted during cardiac surgery, many cardiac surgeons give fibrinogen to control bleeding during surgery for high-risk patients. The efficacy of this treatment, however, had not been previously confirmed in large, randomized clinical trials. A recent study in the Netherlands randomized 120 high-risk cardiac surgery patients with intraoperative bleeding to receive either fibrinogen concentrate or a placebo during elective surgery. Over 70% of the surgeries were either coronary artery bypass grafts or valve repair or replacements, and the surgeries on average lasted more than three hours. Intraoperative blood loss was similar in both groups-the median blood loss in the patients that received fibrinogen concentrate was 50 mL (IQR 29-100 mL) while the group receiving the placebo lost a median of 70 mL of blood (IQR 33-145 mL; p=0.19). Furthermore, additional adverse events occurred in the patients who received fibrinogen up to 30 ...
The Surgical sealants and adhesives market is estimated to reach $2.64 Billion by 2020, growing at a CAGR of 9.2% during the forecast period (2015 to 2020). This market is mainly driven by increasing surgical applications of surgical adhesives, growing need to manage blood loss, greater uptake of technologically advanced products, and increasing regulatory approvals.
TissuePatchDural™ is a surgical sealant film, specifically designed to reinforce closure of the Dura Mater to achieve a watertight seal.. It is a self-adhesive film comprising synthetic polymers that are encountered in everyday surgery. It contains no human, bovine or porcine material,. It is multi-layered, incorporating structural and adhesive absorbable components.. The active component within TissuePatchDural™ is Tissuemeds proprietary TissueBond™ bioadhesive technology. This bonds the film to proteins on the tissue surface within a minute, providing immediate support and an effective watertight closure during the natural healing process.. ...
Press Release issued Apr 21, 2017: Global Surgical Sealants & Adhesives Market is expected to grow from $1.68 billion in 2016 to reach $3.28 billion by 2022 with a CAGR of 11.7 %. The factors favouring the growth of the market are increasing number of surgical procedures and raising demand for technological advanced products with FDA and CE mark approvals. In addition, insufficient reimbursements, huge costs involved in clinical data requirement in launching and designing new products are some factors hindering the market.
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The aim of this study was to compare two hemostatic techniques, minimum pressure technique and patent hemostasis, on radial artery occlusion (RAO) after transradial catheterization.
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 A combination of bottom-up and top-down approaches was used to calculate the market sizes and growth rates of the market and its subsegments. All percentage shares, splits, and breakdowns were determined using secondary sources and verified through primary sources. All the possible parameters that affect...
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A medical closure device ( 20 ) is provided, which comprises a tubular member ( 21 ) provided with a first set of struts ( 22 ) that extend between a first end portion ( 24 ) and a central portion ( 25 ) and second set of struts ( 23 ) that extend between said central portion ( 25 ) and a second end portion ( 26 ), and each strut ( 22, 23 ) being provided with a section ( 27, 28 ) that can act as a hinge, such that said closure device ( 20 ) being movable between a first elongated tubular configuration and a second configuration in which the first and second end portions ( 24, 26 ) have been moved towards each other such that the first and second struts ( 22, 23 ) have moved radially away from a longitudinal central axis of the closure device, and wherein the two arms of at least one of the strut sets, in the first configuration, are arranged with positive tilt angle to each other to thereby ensure that the second configuration can be achieved.