Synthesis, construction, and evaluation of self-assembled nano-bacitracin A as an efficient antibacterial agent in vitro and in vivo Wei Hong,1 Xiang Gao,1 Peng Qiu,1 Jie Yang,1 Mingxi Qiao,2 Hong Shi,3 Dexian Zhang,1 Chunlian Tian,1 Shengli Niu,1 Mingchun Liu1 1Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenhe, Shenyang, Liaoning, Peoples Republic of
China; 2Department of Pharmaceutics, School of Pharmacy,
China Pharmaceutical University, Jiangning, Nanjing, 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, Peoples Republic of
China Abstract: Bacitracin A (BA) is an excellent polypeptide antibiotic that is active against gram-positive bacteria without triggering multidrug resistance. However, BA is inactive against gram-negative bacteria because of its inability to cross the outer membrane of these cells, and it has strong nephrotoxicity, thus limiting