1. Key Insights. 2. Executive Summary of Helicobacter Pylori Infections. 3. Competitive Intelligence Analysis for Helicobacter Pylori Infections. 4. Helicobacter Pylori Infections: Market Overview at a Glance. 4.1. Helicobacter Pylori Infections Total Market Share (%) Distribution in 2017. 4.2. Helicobacter Pylori Infections Total Market Share (%) Distribution in 2030. 5. Helicobacter Pylori Infections: Disease Background and Overview. 5.1. Introduction. 5.2. Sign and Symptoms. 5.3. Pathophysiology. 5.4. Risk Factors. 5.5. Diagnosis. 6. Patient Journey. 7. Helicobacter Pylori Infections Epidemiology and Patient Population. 7.1. Epidemiology Key Findings. 7.2. Assumptions and Rationale: 7MM. 7.3. Epidemiology Scenario: 7MM. 7.3.1. Helicobacter Pylori Infections Epidemiology Scenario in the 7MM (2017-2030). 7.4. United States Epidemiology. 7.4.1. Helicobacter Pylori Infections Epidemiology Scenario in the United States (2017-2030). 7.5. EU-5 Country-wise Epidemiology. 7.5.1. Germany ...
Table of Contents. Table of Contents 2. List of Tables 5. List of Figures 5. Introduction 6. Global Markets Direct Report Coverage 6. Helicobacter Pylori Infections Overview 7. Therapeutics Development 8. Pipeline Products for Helicobacter Pylori Infections-Overview 8. Pipeline Products for Helicobacter Pylori Infections-Comparative Analysis 9. Helicobacter Pylori Infections-Therapeutics under Development by Companies 10. Helicobacter Pylori Infections-Therapeutics under Investigation by Universities/Institutes 11. Helicobacter Pylori Infections-Pipeline Products Glance 12. Late Stage Products 12. Clinical Stage Products 13. Early Stage Products 14. Helicobacter Pylori Infections-Products under Development by Companies 15. Helicobacter Pylori Infections-Products under Investigation by Universities/Institutes 16. Helicobacter Pylori Infections-Companies Involved in Therapeutics Development 17. Daewoong Pharmaceutical Co., Ltd. 17. EpiVax, Inc. 18. ImevaX GmbH 19. ImmunoBiology Ltd. 20. RedHill ...
Helicobacter pylori infection attacks the mucus of the stomach since it survives in acidic environment. However, the symptoms do not manifest in the … there is also a loss of appetite, and weight loss, blood in the stool in 25% of the …. Mom with Rare Blood Disorder Adopts 3 Kids with Same Condition ; 11 Weird Things People Have Swallowed ; Weight-Loss Procedure Makes Stomach into Accordion …. weight loss may affect bone mass and result in bone mineral density changes (BMD) and osteoporosis (2-6). Helicobacter pylori (H.pylori) which is a known cause of gastritis and peptic ulcer disease is associated with …. Journal of Gastroenterology, 134, 306-323. 5. Smoot, D.T. (1997) How Does Helicobacter Pylori Cause Mucosal Damage? Direct Mechanisms. Gastroenterology, 113, S31-S34. 6. Monzón, H., Forne, M., Rosinach, M., Loras, C., et …. Helicobacter pylori (H. pylori) infection - Comprehensive overview covers symptoms, treatment of infection with Helicobacter pylori bacteria.. Many of these ...
TY - JOUR. T1 - Antibiotic resistance in Helicobacter pylori strains and its effect on H. pylori eradication rates in a single center in Korea. AU - An, Byoungrak. AU - Moon, Byung Soo. AU - Kim, Heejung. AU - Lim, Hyun Chul. AU - Lee, Yong Chan. AU - Lee, Gyusang. AU - Kim, Sa Hyun. AU - Park, Min. AU - Kim, Jong Bae. PY - 2013/12/4. Y1 - 2013/12/4. N2 - Background: Clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin have been commonly used for the eradication of Helicobacter pylori. We compared the change in antibiotic resistance of H. pylori strains during two separate periods and investigated the effect of antibiotic resistance on H. pylori eradication. Methods: H. pylori strains were isolated from 71 patients between 2009 and 2010 and from 94 patients between 2011 and 2012. The distribution of minimal inhibitory concentration (MIC) of 5 antibiotics was assessed using the agar dilution method, and H. pylori eradication based on the antimicrobial susceptibility of the ...
TY - JOUR. T1 - Helicobacter pylori infection in pregnant women in four districts of Uganda. T2 - Role of geographic location, education and water sources. AU - Baingana, Rhona Kezabu. AU - Kiboko Enyaru, John. AU - Davidsson, Lena. PY - 2014/9/4. Y1 - 2014/9/4. N2 - Background: The prevalence of Helicobacter pylori infection varies in relation to geography, ethnicity and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the epidemiology of this infection in pregnant women in Uganda to provide background data for a study into the effect of H. pylori infection during pregnancy on the hematological response to iron supplementation.Methods: Using a cross-sectional design, H. pylori infection was assessed by the stool antigen test among 447 pregnant women attending antenatal care clinics in Apac, Mbale, Mbarara and Rakai Districts which are in different geographical regions in ...
TY - JOUR. T1 - Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. AU - Maeda, S.. AU - Yoshida, H.. AU - Ikenoue, T.. AU - Ogura, K.. AU - Kanai, F.. AU - Kato, Nobuyuki. AU - Shiratori, Y.. AU - Omata, M.. PY - 1999. Y1 - 1999. N2 - Background - cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. Aim - To characterise cagA and the cag PAI in Japanese Hpylori strains. Methods - H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from Western countries were also studied. Induction of interleukin-8 secretion from gastric epithelial cells was also investigated. Results - All Japanese strains retained cagA. Fifty nine of 63 (94%) strains had all the cag PAI genes. In the remaining four, cag PAI was partially deleted, lacking cagA transcripts and not producing CagA protein. ...
TY - JOUR. T1 - Clinical outcomes of standard triple therapy plus probiotics or concomitant therapy for Helicobacter pylori infection. AU - Jung, Jae Hyun. AU - Cho, In Kuk. AU - Lee, Chang Hee. AU - Song, Gwan Gyu. AU - Lim, Ji Hyun. PY - 2018/3/1. Y1 - 2018/3/1. N2 - Background/Aims: The efficacy of standard triple therapy (STT) in treating Helicobacter pylori infection has decreased. Many investigators have attempted to increase the eradication rate. We investigated the outcomes of concomitant therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for H. pylori infection. Methods: We reviewed the medical records of 361 patients who received either STP (n=286) or CT (n=75). The STP group received STT combined with a probiotic preparation for 1 week. The CT group received STT and metronidazole for 1 week. Results: The intention-to-treat and per-protocol eradication rates were 83.6% (95% confidence interval [CI], 79.0 to 87.7) and 87.1% (95% CI, 81.2 to 89.7) in the STP ...
The modern methods used in medical research are increasingly demonstrating the importance of the human microbiome for a persons general health. The microbiome refers to all the bacteria that live in an organ system or ecosystem. It is constantly adapting to changes in the ecosystem, such as changes in lifestyle or eating habits, for example.. A few months ago, working in collaboration with the Austrian Society of Gastroenterology and Hepatology, a team of researchers led by infectionologist Christoph Steininger from the Division of Infectious Diseases and Tropical Medicine at MedUni Viennas Department of Medicine I conducted a large-scale study into antibiotic resistance of Helicobacter pylori in Austria.. Helicobacter pylori is a common bacterium that can cause gastritis and stomach cancer. Symptoms can vary a great deal, ranging from loss of appetite and nausea through to upper abdominal pain. It was found that Helicobacter pylori infection is often resistant to standard antibiotics and ...
Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the hosts life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in sev …
TY - JOUR. T1 - Association of Helicobacter pylori infection and diet on the risk of gastric cancer. T2 - A case-control study in Hawaii. AU - Epplein, Meira. AU - Nomura, Abraham M.Y.. AU - Hankin, Jean H.. AU - Blaser, Martin J.. AU - Perez-Perez, Guillermo. AU - Stemmermann, Grant N.. AU - Wilkens, Lynne R.. AU - Kolonel, Laurence N.. PY - 2008/10/1. Y1 - 2008/10/1. N2 - Objective: The risk factors most strongly associated with gastric cancer are the gastric bacteria Helicobacter pylori and diet. Utilizing data from a case-control study among residents in Hawaii, we examined the association of diet, presence of H. pylori, and non-cardia gastric cancer risk. Methods: Serum taken at diagnosis for cases (n = 212) and at interview for controls (n = 336) was assayed for IgG antibodies to H. pylori group antigens and to a recombinant fragment of the cytotoxin-associated antigen A (CagA) protein, and subjects completed food frequency questionnaires. Risk measures were calculated using logistic ...
TY - JOUR. T1 - Helicobacter pylori eradication may induce de novo, but transient and mild, reflux esophagitis. T2 - Prospective endoscopic evaluation. AU - Take, Susumu. AU - Mizuno, Motowo. AU - Ishiki, Kuniharu. AU - Nagahara, Yasuhiro. AU - Yoshida, Tomowo. AU - Yokota, Kenji. AU - Oguma, Keij. AU - Okada, Hiroyuki. AU - Yamamoto, Kazuhide. PY - 2009/1. Y1 - 2009/1. N2 - Backgrounds and Aim: The effect on reflux esophagitis of eradicating Helicobacter pylori is variable and not fully defined. We previously reported that in patients who have reflux esophagitis associated with duodenal ulcer, a significant improvement in the pre-existing reflux esophagitis occurred after H. pylori was eradicated. In the present study, we asked whether H. pylori eradication leads to de novo development of reflux esophagitis in peptic ulcer patients. Methods: Prospective post-eradication evaluations were conducted in 1195 H. pylori-positive patients with peptic ulcer diseases who were confirmed not to have ...
For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Then, invasive tests i.e. gastroscopy are necessary to confirm the infection. As antibiotics are not widely available in children affected by Helicobacter pylori infection, they should be chosen based on individual antibiotic susceptibility testing obtained by gastric biopsy specimens or the local antibiotic resistance pattern, in empirical treatment is chosen. Test and treat strategy in children should be avoided. In this brief review we summarize how and in which children the infection should be investigate and which the most appropriate ...
Helicobacter pylori infection causes peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer [1]. Most international guidelines recommended triple-therapy regimens consisting of a proton pump inhibitor (PPI), clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of H. pylori [2-4]. However, the eradication frequency of standard triple therapy has fallen to less than 80% in many countries because of the rising prevalence of clarithromycin resistance [5-7]. The rate of clarithromycin resistance is reported to be as high as 37.3% in Korea. Consequently, the first-line eradication rate of triple therapy has been shown to be 74% according to a national database [8, 9]. Despite this issue, the standard triple-therapy regimen is still recommended for first-line therapy in Korea according to the revised guidelines, and it is the only regimen reimbursed by the Korean National Health Insurance Service [10].. Several strategies, including ...
TY - JOUR. T1 - Ulcer site and complications. T2 - Relation to Helicobacter pylori infection and NSAID use. AU - Al-Assi, M. T.. AU - Genta, R. M.. AU - Karttunen, T. J.. AU - Graham, D. Y.. PY - 1996/2. Y1 - 1996/2. N2 - Background and Study Aim: The aim of this study was to investigate the relationship between the presence and location of ulcers, H. pylori infection, NSAID use, and major upper gastrointestinal tract bleeding. Patients and Methods: We studied 100 consecutive patients with duodenal ulcers and 145 consecutive patients with benign gastric ulcers. Results: Ninety-nine percent of the duodenal ulcer patients and 92% of the gastric ulcer patients had H. pylori infection; all gastric ulcer patients without H. pylori infection were using NSAIDs. Gastric ulcers in patients with H. pylori infection who were not using NSAIDs were more likely to be on the lesser curvature (85%) than ulcers in NSAID users who had no H. pylori infection (36%) (p , 0.01). Conversely, only 5% of gastric ulcers ...
La résistance à lamoxicilline reste exceptionnelle (, 1 %). Rescue therapy with rifabutin after multiple H. pylori treatment failures (abstract).Intact H. pylori bacteria induced IL-8 secretion from cells expressing TLR2 and CD14 but not from cells expressing TLR4 and CD14 or CD14 alone (Fig. (Fig.2A). 2A).Amoxicillin; Anti-Ulcer Agents; Omeprazole; Bacterial Proteins; Bismuth; Antigens, Bacterial;. i have had h pylori for 6 months. i took treatment for it last month.HELICOBACTER PYLORI. Les infections à H. pilori,. In Vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of.HELICOBACTER PYLORI - Natural treatments for the eradication of the HP bacterium. Helicobacter pylori (HP) is a bacterium which infects the mucous lining of the human.. Les CMI de H. pylori & Iamoxicilline sont en general tres basses. Keller J.J. Rauws E.AJ Tytgat G.NJ. Treatment of Helicobacter pylori infection:.H. pylori eradication treatment to patients with a history ...
China Rapid Test Analyzer for Helicobacter Pylori, Hubt-20, Find details about China Helicobacter Pylori, H. Pylori from Rapid Test Analyzer for Helicobacter Pylori, Hubt-20 - Shenzhen Zhonghe Headway Bio-Sci & Tech Co., Ltd.
TY - JOUR. T1 - Helicobacter pylori strain types and risk of gastric cancer. T2 - A case-control study. AU - Enroth, H.. AU - Kraaz, W.. AU - Engstrand, L.. AU - Nyren, O.. AU - Rohan, T.. PY - 2000/10/16. Y1 - 2000/10/16. N2 - The aim of this novel endoscopy clinic-based case-control study was to explore the influence of different Helicobacter pylori strain types on the risk of gastric adenocarcinoma using isolated bacterial strains, tissue samples, and sera. We included 72 cases with gastric adenocarcinoma and 324 age- and sex-matched controls. Histological characterization, culture, molecular typing of H. pylori genes by PCR (cagA/vacA), conventional IgG ELISA, and immunoblotting (Western blot) for the CagA and VacA proteins were performed. With four tests combined, H. pylori infection was detected in 57 (79%) cases and 213 (66%) controls. A positive association between H. pylori infection and gastric cancer risk was found [odds ratio (OR), 2.1; 95% confidence interval, 1.1-3.9]. Type I (OR, ...
Background:. Helicobacter pylori (HP) play an important role in the pathogenesis of chronic gastritis, peptic ulcer diseases as well as gastric cancer. Helicobacter pylori eradication is a critical strategy to reduce aforementioned conditions. Proton-pump inhibitor (PPI)-based triple therapy (Standard dose PPIs+ Clarithromycin 1g/D + Amoxycillin 2g/D or Metronidazole 800 mg/D) is recommended as a frontline treatment in current guidelines for HP eradication, both from Thai and Second Asia-Pacific Consensus Guideline for H.pylori 2009. Unfortunately, it has been reported an unacceptably low eradication rate (,85%) of this regimen in a tertiary care hospital in Thailand. This occurrence is not surprised as the worldwide efficacy of this regimen had decreased to 50-75%. Of this, Clarithromycin resistance has been a major cause of the treatment failure.. Sequential therapy (ST) which consists of standard dose PPIs + amoxycillin 2 g/D for 5 days with 5 additional days of clarithromycin 1g/D + ...
Background:. Helicobacter pylori (HP) play an important role in the pathogenesis of chronic gastritis, peptic ulcer diseases as well as gastric cancer. Helicobacter pylori eradication is a critical strategy to reduce aforementioned conditions. Proton-pump inhibitor (PPI)-based triple therapy (Standard dose PPIs+ Clarithromycin 1g/D + Amoxycillin 2g/D or Metronidazole 800 mg/D) is recommended as a frontline treatment in current guidelines for HP eradication, both from Thai and Second Asia-Pacific Consensus Guideline for H.pylori 2009. Unfortunately, it has been reported an unacceptably low eradication rate (,85%) of this regimen in a tertiary care hospital in Thailand. This occurrence is not surprised as the worldwide efficacy of this regimen had decreased to 50-75%. Of this, Clarithromycin resistance has been a major cause of the treatment failure.. Sequential therapy (ST) which consists of standard dose PPIs + amoxycillin 2 g/D for 5 days with 5 additional days of clarithromycin 1g/D + ...
Whole-genome sequencing is becoming a leading technology in the typing and epidemiology of microbial pathogens, but the increase in genomic information necessitates significant investment in bioinformatic resources and expertise, and currently used methodologies struggle with genetically heterogeneous bacteria such as the human gastric pathogen Helicobacter pylori. Here we demonstrate that the alignment-free analysis method feature frequency profiling (FFP) can be used to rapidly construct phylogenetic trees of draft bacterial genome sequences on a standard desktop computer and that coupling with in silico genotyping methods gives useful information for comparative and clinical genomic and molecular epidemiology applications. FFP-based phylogenetic trees of seven gastric Helicobacter species matched those obtained by analysis of 16S rRNA genes and ribosomal proteins, and FFP- and core genome single nucleotide polymorphism-based analysis of 63 H. pylori genomes again showed comparable ...
TY - JOUR. T1 - Histological diagnosis of Helicobacter pylori using biopsy specimens. AU - Ota, Hiroyoshi. AU - Hosoda, Kazuki. AU - Kobayashi, Mikiko. AU - Genta, Robert M.. PY - 2003. Y1 - 2003. N2 - Helicobacter pylori(H. pylori) are an organism that can be confidently recognized by histology. Using histological specimens, we can both identify infection and assess pathological condition associated with H. pylori. For the precise diagnosis, biopsies should be taken from suitable sites(greater curvature of antrum and corpus) and the valuable requirements are to recognize several pathologic findings of H. pylori--infected gastric mucosa(epithelial changes and neutrophilic infiltration together with mononuclear cell infiltration) and to use special staining methods for H. pylori(i.e. Giemsa staining, Gimenez staining, silver staining, and immunostaining) in addition to HE staining.. AB - Helicobacter pylori(H. pylori) are an organism that can be confidently recognized by histology. Using ...
ARAYA O, Juan Carlos et al. Association between helicobacter pylori genotype and the severity of gastritis in infected adults. Rev. méd. Chile [online]. 2004, vol.132, n.11, pp.1345-1354. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872004001100002.. Background: The damaging capacity of Helicobacter pylori is variable and depends, in part, on its genetic polymorphism. Aim: To study H pylori genes vacA, cagA and iceA and the relationship of these genotypes with the features of acute damage in chronic gastritis. Material and methods: Gastric endoscopic biopsies were obtained in 75 adults for pathological study and genetic typification of H pylori by specific PCR. Results: In only 64 cases, complete information was available. In 53 of these, there was H pylori infection demonstrated by PCR. Twenty one percent had infection by two or more H pylori strains, vacA gene had genotypes s2/m2, s1/m1 and s1/m2 in 36, 25 and 8% of cases respectively, cagA gene was present in 49% of infected patients. ...
Helicobacter pylori infection is the most important etiologic factor in chronic gastritis and gastroduodenal ulcer disease. Approximately 30% of patients with dyspepsia in North America are infected with H pylori; the annual incidence of new infections is about 0.5 per 100 persons in the susceptible population. In the developing world, prevalence among patients with dyspepsia is 80% to 90%, and the annual incidence of new infections is 3 or more per 100 susceptible persons. Presence of H pylori is closely related to development of gastric cancer. Eradication of the organism results in ulcer healing and reduces risk of ulcer recurrence and complications. Diagnostic methods for H pylori infection are direct or invasive (identifying the microorganism by gastric biopsy) and indirect or noninvasive (detecting certain characteristics of the bacteria). The latter can include the capacity of H pylori to hydrolyze urea (eg, urea breath test [UBT]) or quantification of specific antibodies (eg, various ...
Background. Our aim was to evaluate the accuracy of the stool antigen test and the optimal time point for detecting Helicobacter pylori infection in a Mongolian gerbil model. Methods. We inoculated 8-week-old Mongolian gerbils with H. pylori (Vac A (+)/CagA(+)). The gerbil-infected model was developed as follows: H. pylori was put into broth (about 109 CFU/ml), and 50 gerbils were then fed with 1 ml intragastrically twice within a 3-day interval. Another ten gerbils were fed broth only. Twenty-six weeks after the inoculation, the gerbils were killed. The gastric mucosa was sampled for a series of examinations including culture, histology, rapid urease test, and polymerase chain reaction. Stool samples for a stool antigen test, H. pylori-specific stool antigen assay (HpSA), were collected during weeks 4, 6, 8, 12, and 26 after inoculation. Of the 50 gerbils inoculated with H. pylori, the inoculation was successful in 88%. Severe active gastritis, ulceration, and intestinal metaplasia were obvious.
We read with great interest the paper by Choe and colleagues which investigated a possible relationship betweenHelicobacter pylori infection, iron deficiency anaemia (IDA), and subnormal growth at puberty.1 The authors concluded that H pylori infection and related IDA, rather than bacterial infection alone, might cause delayed pubertal growth. However, we believe that these results need some consideration.. H pylori infection may cause IDA in different ways: (a) the bacterium can cause a decrease in the gastric juice of the concentration of ascorbic acid, which is the best promoter of non-heme iron absorption2; (b) H pylori may increase iron demand because iron is an essential bacterial growth factor; (c) H pyloricontains a 19.6 kDA protein resembling ferritin with a binding activity for heme iron in erythrocytes3; (d) acute or chronic blood loss and IDA are associated with typical H pylori related gastroduodenal lesions. In Choes study, the treatment of H pylori infection with antibiotics (but ...
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Background: The prevalence of Helicobacter pylori (H. pylori) infection is reported to be more than 50% worldwide. It has been associated with peptic ulcer disease, gastric carcinoma, and mucosal-associated lymphoid tissue lymphoma. The seroprevalence of H. pylori varies greatly among societies and geographical locations. The objective of this study was to determine the seroprevalence and factors associated with H. pylori infection among dyspeptic patients in Afghanistan. Materials and Methods: This cross-sectional study was designed to determine the seroprevalence of H. pylori among dyspeptic patients in an outpatient clinic in Andkhoy, Afghanistan from January 2017 to April 2017. Data were obtained from patients using a questionnaire, including socio-demographic data and history of smoking and dyspeptic symptoms. Serum samples were also collected from the patients and tested for H. pylori antibodies using the enzyme-linked immunosorbent assay. Results: A total of 152 patients with dyspepsia were
Helicobacter pylori is an important global pathogen infecting approximately 50% of the worlds population. This study was undertaken in order to estimate the prevalence rate of Helicobacter pylori infections among adults living in Turkey and to investigate the associated risk factors. This study was a nationally representative cross sectional survey, using weighted multistage stratified cluster sampling. All individuals aged ≥18 years in the selected households were invited to participate in the survey. Ninety two percent (n = 2382) of the households in 55 cities participated; 4622 individuals from these households were tested with the 13C-Urea breath test. Helicobacter pylori prevalence and associated factors were analysed by the t test, chi square and multiple logistic regression with SPSS11.0. The weighted overall prevalence was 82.5% (95% CI: 81.0-84.2) and was higher in men. It was lowest in the South which has the major fruit growing areas of the country. The factors included in the final model
Helicobacter pylori is an important global pathogen infecting approximately 50% of the worlds population. This study was undertaken in order to estimate the prevalence rate of Helicobacter pylori infections among adults living in Turkey and to investigate the associated risk factors. This study was a nationally representative cross sectional survey, using weighted multistage stratified cluster sampling. All individuals aged ≥18 years in the selected households were invited to participate in the survey. Ninety two percent (n = 2382) of the households in 55 cities participated; 4622 individuals from these households were tested with the 13C-Urea breath test. Helicobacter pylori prevalence and associated factors were analysed by the t test, chi square and multiple logistic regression with SPSS11.0. The weighted overall prevalence was 82.5% (95% CI: 81.0-84.2) and was higher in men. It was lowest in the South which has the major fruit growing areas of the country. The factors included in the final model
This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought.. ...
TY - JOUR. T1 - Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori. AU - Kudo, Takahiko. AU - Lu, Hong. AU - Wu, Jeng Yih. AU - Graham, David Y.. AU - Casola, Antonella. AU - Yamaoka, Yoshio. PY - 2005/11. Y1 - 2005/11. N2 - RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the gastric mucosa is unknown. We cocultured gastric epithelial cells with wild-type H. pylori, isogenic oipA mutants, cag pathogenicity island. (PAI) mutants, or double knockout mutants. Reverse transcriptase PCR showed that RANTES mRNA was induced by H. pylori and that the expression was both OipA and cag PAI dependent. Luciferase reporter gene assays and electrophoretic mobility shift assays showed that maximal H. pylori-induced RANTES gene transcription required the presence of the interferon-stimulated responsive element ...
Eradicating Helicobacter pylori infection is clinically challenging, notably in cases with penicillin allergy. Cephalosporin could be used in lieu of amoxicillin to eradicate Helicobacter pylori. The current work aimed to assess therapeutic efficacy and safety of a cefuroxime-based quadruple regimen in treatment-naïve individuals with penicillin allergy, as well as patient compliance. In the present prospective single-center cohort study, 152 Helicobacter pylori infected individuals with penicillin allergy received eradication therapy with cefuroxime (500 mg twice/day), levofloxacin (500 mg once/day), esomeprazole (20 mg twice/day) and bismuth potassium citrate (220 mg twice/day; 14 days). Safety and compliance were evaluated 1 to 3 days upon eradication. The urea breath test was carried out 8 to 12 weeks upon eradication for efficacy assessment. This quadruple antimicrobial regimen eradicated the pathogen at 85.5% (95% confidence interval (CI) 79.6-90.8%), 88.4% (95% CI 83.0-93.2%) and 90.1% (95% CI
A 28-year-old male patient presented in January 1996 with the symptoms of ulcer like dyspepsia. There was no significant abnormality on physical examination, laboratory testing and abdominal ultrasound. Histology examination of the biopsy specimen taken during the upper endoscopy revealed Helicobacter pylori associated active gastritis only in the corporal part of the stomach. After two weeks eradication therapy (Omeprazole, Amoxicillin) he was well. Three months later, at the control endoscopy, granulomatous gastritis of the corporal localization was detected, without Helicobacter pylori present. Antral mucosa appeared normal, both, on endoscopy and histology examination. In July 1996 he started with cramping abdominal pain, mild periodical fever and episodes of watery diarrhea. In laboratory results we found nonspecific signs of inflammation. We repeated upper endoscopy, colonoscopy and enteroclysis--with evidence of segmental stenotic lesions of the upper part of ileum and jejunum. Again, we ...
This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. On current evidence, H. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. The emerging problem of antibiotic resistance in H. pylori is of major clinical importance and a prime cause of treatment failure. There is increasing evidence of a link between H. pylori and gastric cancer but it is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer. The search continues for the ideal H. pylori eradication regimen.. ...
BACKGROUND/AIM: Helicobacter pylori is a Gram-negative bacteria, which is associated with development of gastroduodenal diseases. The prevalence of H. pylori and the virulence markers cytotoxin-associated gene A and E (cagA, cagE) and vacuolating-associated cytotoxin gene (vacA) alleles varies in different parts of the world. H. pylori virulence markers cagA, cagE, and vacA alleles in local and Afghan nationals with H. pylori-associated gastroduodenal diseases were studied. PATIENTS AND METHODS: Two hundred and ten patients with upper gastrointestinal symptoms and positive for H. pylori by the urease test and histology were included. One hundred and nineteen were local nationals and 91 were Afghans. The cagA, cagE, and vacA allelic status was determined by polymerase chain reaction. RESULTS: The nonulcer dyspepsia (NUD) was common in the Afghan patients (P = 0.025). In Afghan H. pylori strains, cagA was positive in 14 (82%) with gastric carcinoma (GC) compared with 29 (45%) with NUD (P = 0.006),
To evaluate the frequency of Helicobacter pylori (H. pylori) CagA antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori CagA-immune response ...
Helicobacter pylori (H. pylori) is closely associated with chronic gastritis, peptic ulcer disease, and gastric adenocarcinoma and lymphoma. Helicobacter pylori neutrophil-activating protein (HP-NAP) is an important virulence factor of H. pylori for its pathogenesis. To investigate how HP-NAP activates human neutrophils, HP-NAP was expressed in Escherichia coli (E.coli), purified by the two sequential gel filtration chromatographies, and then subjected to filtration for the removal of endotoxin. The recombinant HP-NAP was able to stimulate human neutrophils to produce reactive oxygen species (ROS) as examined by luminol-enhanced chemiluminescent assay. HP-NAP can also promote the secretion of myeloperoxidase (MPO) in human neutrophils. The finding of this new function of HP-NAP in human neutrophils suggests that there should be more host immune responses of HP-NAP awaited to be explored ...
Background & alms: The main cause of chronic gastritis is Helicobacter pylori (H. pylori). Clinical manifestations of chronic gastritis are ulcer disease, gastric cancer and mucosa-associated lymphoma tissue (MALT) lymphoma in the stomach. It is uncertain whether gastritis can be diagnosed macroscopically at endoscopy. H. pylori infection may be diagnosed by several different methods, the accuracy of which needs to be explored. Some individuals with H. pylori related chronic gastritis will develop atrophy of the gastric mucosa. This condition is the main risk factor for cancer development and may also be associated with vitamin B12 deficiency leading to hyperhomocysteinaemia. The natural history of chronic gastritis in terms of development of atrophy and ulcer disease in the adult general population is largely unknown.. Material & methods: A sample of 50 I volunteers from the general population in the municipality of Linköping was examined with esophago-gastro-duodenoscopy (EGD) with biopsy. ...
Murakami, K., Kodama, M. and Fujioka, T. (2006) Latest Insights into the Effects of Helicobacter Pylori Infection on Gastric Carcinogenesis. World Journal of Gastroenterology, 12, 2713-2720.
Abstract: Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related with H pylori infection.This study analyzed expression of anti-Helicobacter pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This study was a observational descriptive study with case control design. Thirty (30) samples from paraffin bloc that were diagnosed with chronic gastritis, precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013 was stained by hematoxylin eosin, giemsa and immunohistochemistry of anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty (30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred at ...
Background The ArsRS two-component system is the master regulator of acid adaptation in the human gastric pathogen Helicobacter pylori. Low pH is supposed to trigger the autophosphorylation of the histidine kinase ArsS and the subsequent transfer of the phosphoryl group to its cognate response regulator ArsR which then acts as an activator or repressor of pH-responsive genes. Orthologs of the ArsRS two-component system are also present in H. pyloris close relatives H. hepaticus, Campylobacter jejuni and Wolinella succinogenes which are non-gastric colonizers. Methodology/Principal Findings In order to investigate the mechanism of acid perception by ArsS, derivatives of H. pylori 26695 expressing ArsS proteins with substitutions of the histidine residues present in its periplasmic input domain were constructed. Analysis of pH-responsive transcription of selected ArsRS target genes in these mutants revealed that H94 is relevant for pH sensing, however, our data indicate that protonatable amino acids
TY - JOUR. T1 - Does Helicobacter pylori infection increase the risk of Barretts esophagus and esophageal adenocarcinoma?. AU - Erőss, Bálint. AU - Tinusz, Benedek. AU - Farkas, Nelli. AU - Hegyi, P.. PY - 2018/1/1. Y1 - 2018/1/1. UR - http://www.scopus.com/inward/record.url?scp=85053805073&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85053805073&partnerID=8YFLogxK. U2 - 10.1111/hel.12539. DO - 10.1111/hel.12539. M3 - Article. C2 - 30251295. AN - SCOPUS:85053805073. JO - Helicobacter. JF - Helicobacter. SN - 1083-4389. ER - ...
Helicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to find alternative therapies, particularly in the nutritional field. The current study evaluated whether curcumin could attenuate inflammation of the gastric mucosa due to H. pylori infection. Twenty-eight C57BL/6 mice, were inoculated with the H. pylori SS1 strain; ten non-infected mice were used as controls. H. pylori infection in live mice was followed-up using a modified 13C-Urea Breath Test (13C-UBT) and quantitative real-time polymerase chain reaction (PCR). Histologically confirmed, gastritis was observed in 42% of infected non-treated mice at both 6 and 18 weeks post-infection. These mice showed an up-regulation of the expression of inflammatory cytokines and chemokines, as well as of toll-like receptors (TLRs) and MyD88, at both time ...
BACKGROUND Different therapeutic regimens were used for eradication of Helicobacter pylori, based on the cost, effectiveness and patients compliance. The aim of this study was the evaluation of licorice compared with bismuth in quadruple regimen on eradication of H. pylori in patients with peptic ulcer disease (PUD). MATERIALS AND METHODS In a double-blind clinical trial study, 60 patients with PUD and positive rapid urease test were enrolled. The patients were randomly allocated into two equal groups. In first group, licorice, amoxicillin, metronidazole and omeprazole and in the second (control) group, bismuth subsalicylate, amoxicillin, metronidazole and omeprazole were prescribed respectively, and 4 weeks after treatment, in order to evaluate H. pylori eradication, urea breath test was done in all patients. The outcome of the study was the preference usage of licorice as an effective medication for H. pylori eradication. RESULTS Mean age of the patients in the control and case groups were ...
Arrhythmia is a common disease around the world and Helicobacter pylori (H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori. In the arrhythmia group, 392 (58.1%) were H. pylori-positive and in the control group 640 (47.8%) were H. pylori-positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081-2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may
High prevalence of clarithromycin resistance and effect on Helicobacter pylori eradication in a population from Santiago, Chile: cohort study and meta- ...
The Gram-negative bacterium Helicobacter pylori is a causative agent of gastritis and peptic ulcer disease in humans. Strains producing the CagA antigen (cagA +) induce strong gastric inflammation and are strongly associated with gastric adenocarcinoma and MALT lymphoma. We show here that such strains translocate the bacterial protein CagA into gastric epithelial cells by a type IV secretion system, encoded by the cagpathogenicity island. CagA is tyrosine-phosphorylated and induces changes in the tyrosine phosphorylation state of distinct cellular proteins. Modulation of host cells by bacterial protein translocation adds a new dimension to the chronicHelicobacter infection with yet unknown consequences. ...
Helicobacter pylori infection is associated with 95% of duodenal ulcers and more than 80% of gastric ulcers. Several reports have indicated that screening for H pylori may avoid subsequent endoscopic examination. We screened 183 dyspeptic patients, aged under 45, by taking a history of sinister symp …
Introduction: The diffuse type of gastric adenocarcinoma has been found to be more prevalent in low risk countries like Cameroon. The objective of this study was to determine the most frequent histological type of gastric cancer found in Yaoundé and its association to the Helicobacter pylori infection. Materials and Methods: The registries of histopathology laboratories of 4 reference hospitals in Yaoundé, Cameroon have been reviewed for registered primitive gastric malignancies from July 2009 to May 2014. Paraffin blocks mounted on slides and stained with Hematoxylyn and Eosin of gastric cancer cases were re-stained Giemsa to search for Helicobacter pylori and they were classified using the criteria of Lauren in intestinal type or diffuse type. Results: Forty-two cases were reviewed: 25 (59.5%) of them were intestinal type of gastric adenocarcinoma, 11 (26.2%) were diffuse type, 4 (9.5%) were malignant gastric lymphoma, 1 (2.4%) was a stromal tumor, and 1 (2.4%) was a colloid carcinoma. The most
To determine the frequency of Helicobacter pylori infection in patients with lichen planus presented to tertiary care hospital Hyderabad. Patiehts and Methods This cross sectional descriptive study of six months was carried at Liaquat University Hospital Hyderabad Sindh, Pakistan from February 2008 to July 2008. All patients above 12 years of age, of either gender, were known / already diagnosed and newly diagnosed cases of lichen planus (LP) were came through outdoor patient department (OPD), indoor patient and causality outdoor department (COD) were evaluated and enrolled in the study. All such patients were screened for Helicobacter pylori infection by Helicobacter pylori stool antigen (HpSA). For getting result the data was saved and analyzed in SPSS version 10.00. RESULT: One hundred and five patients (105) were identified as lichen planus and screened for Helicobacter pylori infection. The Helicobacter pylori stool antigen (HpSA) was positive in 81 (77%) subjects with mean age 42.89 � ...