Objective: To investigate the role of obesity-associated inflammation and immune modulation in gastric carcinogenesis during Helicobacter-induced chronic gastric inflammation. Design: C57BL/6 male mice were infected with H felis and placed on a high-fat diet (45% calories from fat). Study animals were analysed for gastric and adipose pathology, inflammatory markers in serum, stomach and adipose tissue, and immune responses in blood, spleen, stomach and adipose tissue. Results: H felis-induced gastric carcinogenesis was accelerated in diet-induced obese mice compared with lean controls. Obesity increased bone marrow-derived immature myeloid cells in blood and gastric tissue of H felis-infected mice. Obesity also led to elevations in CD4 T cells, IL-17A, granulocyte macrophage colony-stimulating factor, phosphorylated STAT3 and prosurvival gene expression in gastric tissue of H felis-infected mice. Conversely, in adipose tissue of obese mice, H felis infection increased macrophage accumulation and ...
TY - JOUR. T1 - Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice. AU - Chonwerawong, Michelle. AU - Avé, Patrick. AU - Huerre, Michel. AU - Ferrero, Richard L.. PY - 2016/11/21. Y1 - 2016/11/21. N2 - Background: Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic Helicobacter infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in Helicobacter-induced inflammation in BALB/c mice which have Th2-polarised immune responses. Results: At 7 months post-infection with Helicobacter felis, IFN-γ deficiency in BALB/c mice had no significant effect on H. felis colonisation levels in the gastric mucosa, nor on humoral responses, or gastritis severity. Ifng −/− animals with chronic H. felis ...
Helicobacter felis (H. felis) infection has been used for numerous years as a standard model of gastric carcinogenesis and recapitulates the pathogenesis seen with human Helicobacter pylori infection. H. felis induces a a wide array of chronic low grade inflammatory responses, some of which directly contribute to carcinogenesis and some of which do not. To tease out the role of various processes, we have compared and contrasted models that recapitulate H. felis infection or synergize with it, namely, the K19kras transgenic mouse, and diet-induced obesity, respectively. While much attention has been rightly paid to the behavior of transformed cells, some focus has recently shifted to the components of the soil in which tumors develop and grow, commonly referred to as the microenvironment. Here, we investigate the gastric tumor microenvironment and shed light on the role of myofibroblasts, T lymphocytes and myeloid cells. K19kras mice express a mutant K-ras transgene in K19+ cells of the stomach; while
The existence of breed-specific intestinal diseases would suggest that there is an underlying genetic cause to each disease. However, many gastrointestinal (GI) diseases have an infectious aetiology, and suspected inherited diseases can be due to infection transmitted between relatives. In humans, for example, gastric Helicobacter infection most commonly follows infection from the mother, and can lead to a spectrum of disease raging from gastritis to ulcers, mucosal lymphoma and gastric carcinoma. Gastric carcinoma is the most common gastric neoplasm of dogs, and the marked over-representation of the disease in collies, especially Rough collies, suggests a genetic predisposition. However, passage of a pathogenic strain of Helicobacter from dam to pup as the initiating cause cannot be ruled out. For whilst the pathogenicity of Helicobacter in dogs and cats is debated, there is no doubt in veterinary dermatology that the transmission of Demodex from dam to pups occurs, and similar transmission of ...
In this study, we used the hypergastrinemic INS-GAS mouse model to study the effect of H. pylori infection and a high-salt diet on gastric cancer progression. We were able to document H. pylori associated gastric cancer in INS-GAS mice. This appears to be the first report of the induction of gastric cancer by H. pylori in any mouse model and thus confirms the carcinogenicity of this organism. Moreover, the development of gastric cancer over the 7-month observation period was seen only in INS-GAS H. pylori-infected male mice on the low-salt diet.. We previously demonstrated that elevations in gastrin-17 levels have also been associated with an increased risk for gastric glandular atrophy and cancer (21) . Elevation in levels of G-17 in INS-GAS transgenic mice on a FVB background, which we also used in this study, resulted in the spontaneous development of atrophy and gastric cancer in uninfected mice over a period of 1-2 years and more rapid development of cancer (7 months) in H. felis-infected ...
C57BL/6J mice carrying the Min allele of Adenomatous polyposis coli (Apc) develop numerous adenomas along the entire length of the intestine and consequently die at an early age. This short lifespan would prevent the accumulation of somatic genetic mutations or epigenetic alterations necessary for tumor progression. To overcome this limitation, we generated F(1) Apc(Min/+) hybrids by crossing C57BR/cdcJ and SWR/J females to C57BL/6J Apc(Min/+) males. These hybrids developed few intestinal tumors and often lived longer than 1 year ...
ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.. About ASM , Contact Us , Press Room. ASM is a member of. ...
TY - JOUR. T1 - Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. AU - Nomura, Sachiyo. AU - Baxter, Tammy. AU - Yamaguchi, Hirokazu. AU - Leys, Charles. AU - Vartapetian, Andrey B.. AU - Fox, James G.. AU - Lee, Jeffrey R.. AU - Wang, Timothy C.. AU - Goldenring, James R.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2004/8. Y1 - 2004/8. N2 - Background & Aims: The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both rodent and human fundus. To examine the relationship of SPEM to the neoplastic process in the H. felis-infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia. Methods: SPEM-related transcripts were identified by microarray ...
Hypergastrinemia in INS-GAS mice leads to accelerated carcinogenesis of the stomach, but the mechanisms have not been well defined. We investigated the possible role of gastrin-induced gastric cell apoptosis in the development of gastric cancer. We examined apoptosis and the expression of Bcl-2 family proteins in INS-GAS mice of different ages, as well as in gastrin-deficient (GAS-KO) mice after gastrin-17 (G-17) infusion. In addition, we studied the effects of the gastrin/cholecystokinin-2 (CCK-2) receptor antagonist YF476 and/or histamine H2 (H-2) receptor antagonist loxtidine on apoptosis and atrophy in INS-GAS mice with or without Helicobacter felis (H. felis) infection. INS-GAS mice had age-associated increases in Bax protein expression and decreases in Bcl-2 protein expression, along with increased glandular and epithelial cell apoptosis. At 8-week gastrin infusions in GAS-KO mice resulted in a similar pattern of altered Bax and Bcl-2 expression, followed by gastric cell apoptosis. H. felis
OBJECTIVE: Chronic Helicobacter pylori (H. pylori) infection promotes non-cardia gastric cancer. Some mouse models suggest that bone marrow derived cells (BMDC) contribute to Helicobacter-associated gastric carcinogenesis. We determined whether this increased susceptibility to Helicobacter-induced gastric carcinogenesis of p27-deficient mice is dependent upon their p27-null BMDC or their p27-null gastric epithelial cells. DESIGN: Female mice (recipients) were irradiated and transplanted with BMDC from male donors. Wild type (WT) mice in group 1 (control) received BMDC from male GFP-transgenic mice. Female WT and p27 KO mice were engrafted with male p27KO mice BMDC (Group 2) or GFP-transgenic WT BMDC (Group 3). Recipients were infected with H. pylori SS1 for one year. RESULTS: Mice lacking p27 in either the BM pool or gastric epithelium developed significantly more advanced gastric pathology, including high-grade dysplasia. Co-staining of donor BMDC in dysplastic gastric glands was confirmed by
Debate rages over whether or not this condition should be treated or not. Find out what we know and dont know about Helicobacter.
Learn about the veterinary topic of |i|Helicobacter|/i| Infection in Small Animals. Find specific details on this topic and related topics from the Merck Vet Manual.
TLR9 [ENSP00000353874]. Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.. Synonyms: TLR9, TLR9p, hTLR9, C3W5P5, Q9NR96 .... Linkouts: STRING Pharos UniProt ...
Is Stupor a common side effect of Ospamox? View Stupor Ospamox side effect risks. Male, 52 years of age, weighting 187.4 lb, was diagnosed with helicobacter infection and took Ospamox 1000 Mg, Qd.
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A 3-month-old male cat in the animal facility was presented for investigation of anorexia and occasional vomiting. We collected the specimens from gastroscopic biopsy and stool collection. The gastroscopic biopsy specimens were tested using a rapid urease test, CLO Helicobacter-detection kits. Stool specimens were gathered and evaluated using the commercially available SD Bioline H. pylori Ag kit according to the manufacturers instructions. Genomic DNAs from gastroscopic biopsy and stool specimens of the cat were extracted and submitted to the consensus PCR to amplify Helicobacter rpoB gene. Then the DNAs from gastroscopic biopsy and stool specimens were conducted a multiplex species-specific PCR to amplify urease B gene for H. heilmannii, H. pylori and H. felis. As the results, the rapid urease test with gastroscopic biopsy was revealed positive reaction. The result of H. pylori Stool Ag assay was one red line, negative for H. pylori. The gastroscopic biopsy and stool specimen were positive reactions
Is Epileptic Aura a common side effect of Ospamox? View Epileptic Aura Ospamox side effect risks. Male, 52 years of age, weighting 187.4 lb, was diagnosed with helicobacter infection and took Ospamox 1000 Mg, Qd.
Corning™ BioCoat™ Collagen I Rectangular Canted Neck Cell Culture Flask with Vented Cap Culture Area: 25cm2; Vented Cap; 10/pk.; 10/cs....
Get this from a library! Adversario sacra : Accessit eiusd. Psalterii Salomonis ex Gracco MS. Latina verso et ad Tertolliani librum de Pallio Commentarius auctior. [J de la Cerda]
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University college By Simon Cole 11-04-2011. Lorem ipsum dolor sit amet, ctetur adiiscing top of elit. Quisque sit amet sem felis . ...
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This study aimed to compare the epidemiology of Rickettsia felis infection and malaria in France, North Africa, and sub-Saharan Africa and to identify a common vector. Blood specimens from 3,122 febrile patients and from 500 nonfebrile persons were analyzed for R. felis and Plasmodium spp. We observed a significant linear trend (p<0.0001) of increasing risk for R. felis infection. The risks were lowest in France, Tunisia, and Algeria (1%), and highest in rural Senegal (15%). Co-infections with R. felis and Plasmodium spp. and occurrences of R. felis relapses or reinfections were identified. This study demonstrates a correlation between malaria and R. felis infection regarding geographic distribution, seasonality, asymptomatic infections, and a potential vector. R. felis infection should be suspected in these geographical areas where malaria is endemic. Doxycycline chemoprophylaxis against malaria in travelers to sub-Saharan Africa also protects against rickettsioses; thus, empirical treatment
BACKGROUND AND AIMS: Helicobacter pylori is a major cause of peptic ulcers and gastric cancer. Vaccine development is progressing but there is concern that immunisation may exacerbate Helicobacter induced gastritis: prophylactic immunisation followed by challenge with H felis or H pylori can induce a more severe gastritis in mice than seen with infection alone. The aim of this study was to investigate the relationship between immunity to Helicobacter infection and post-immunisation gastritis. METHODS: (1) C57BL/6 mice were prophylactically immunised before challenge with either H felis or H pylori. Histopathology and colonisation were assessed one month post-challenge. (2) C57BL/6 mice were prophylactically immunised against H felis infection and gastritis assessed up to 18 months post-challenge. RESULTS: Prophylactic immunisation induced a reduction in bacterial colonisation following H felis challenge which was associated with increased severity of active gastritis with neutrophil infiltration ...
Helicobacter pylori (H. pylori) infection may contribute to many extragastric diseases including liver cirrhosis and hepatocellular carcinoma. However, the exact mechanism by which H. pylori induces the liver damage is largely unknown. We used cultured mouse primary hepatocytes as an in vitro model …
Takaishi et al suggest that gastrin may serve as a rheostat for the stomach. Gastrin likely plays a central role in the safety network for the protection from mucosal damages caused by gastric acid secretion induced by gastrin itself, and thus either too much or too little gastrin can predispose to carcinogenesis. Therefore, clinicians in the future may need to be more circumspect when prescribing with acid suppressive drugs, such as proton-pump inhibitors, for a long-term use in patients infected with Helicobacter pylori. In future studies, Dr. Wang and colleagues plan to study host factors other than gastrin [that] are also ¦ important for Helicobacter-associated gastric carcinogenesis. These include specific cytokines and chemokines induced by Helicobacter infection, and modulated by gastrin, that link inflammation and cancer. In addition, they plan to study the role of other non-Helicobacter bacteria that colonize the stomach when acid secretion is suppressed, since bacterial overgrowth ...
Ranitidine is useful in any situation where stomach irritation is an issue and ulceration is a concern. It is often used in the treatment of Helicobacter infection, inflammatory bowel disease, canine parvovirus, kidney failure, ingestion of a toxin that could be ulcerating, any disease involving protracted vomiting, or chronically in combination with medications which may have stomach irritating properties.
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The presence of Helicobacter spp. in the gastric mucosa is associated with inflammation and/or ulceration, and these bacteria are recognized as important pathogens in gastroduodenal disease. There is now mounting evidence that suggests that enterohepatic Helicobacter spp. may also be pathogenic for the host. Various other gastric Helicobacter spp. have now been isolated and characterized. Indeed, in rhesus and cynomolgus monkeys, these gastric Helicobacter spp. are indistinguishable from H. pylori, whereas pig-tailed macaques are colonized by H. nemestrinae. Several experimental models have been developed to study the inflammatory processes induced by the murine enterohepatic Helicobacter spp. As H. hepaticus, induces the proliferation of intestinal and hepatic host cells in vivo, it is unlikely that enterocytes or hepatocytes are the target cells for H. hepaticus cytolethal distending toxin (Cdt). Recently, studies in H. pylori SS1-infected mice demonstrated that Helicobacter infection models could
Looking for Felis cattus domesticus? Find out information about Felis cattus domesticus. name applied broadly to the carnivorous mammals constituting the family Felidae, and specifically to the domestic cat, Felis catus. The great roaring cats,... Explanation of Felis cattus domesticus
Helicobacter infection in the stomach is associated with: Gastric carcinoma Acute gastric ulceration Chronic duodenal ulceration Intestinal metaplasia Gastric lymphoma
Acute gastritis is a broad term that encompasses a myriad of causes of gastric mucosal inflammation. Epidemiology It depends on the etiology (see below). Clinical presentation asymptomatic epigastric pain/tenderness nausea and vomiting lo...
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