In the current investigation, TEM in-situ heavy ion (1 MeV Kr{sup 2+}) irradiation with helium pre-injected at elevated temperature (400 °C) was conducted to simulate in-reactor neutron irradiation induced damage in CANDU spacer material Inconel X-750, in an effort to understand the effects of helium on irradiation induced cavity microstructures. Three different quantities of helium, 400 appm, 1000 appm, and 5000 appm, were pre-injected directly into TEM foils at 400 °C. The samples containing helium were then irradiated in-situ with 1 MeV Kr{sup 2+} at 400 °C to a final dose of 5.4 dpa (displacement per atom). Cavities were formed from the helium injection solely and the cavity density and size increased with increasing helium dosage. In contrast to previous heavy ion irradiations with cold pre-injected helium, heterogeneous nucleation of cavities was observed. During the ensuing heavy ion irradiation, dynamical observation showed noticeable size increase in cavities which nucleated close to ...
Several fluorescent materials were tested for use in the imaging screen of a pepper-pot emittance meter that is suitable for investigating the beam dynamics of multiply charged heavy ions extracted from an ECR ion source. SiO{sub 2} (quartz), KBr, Eu-doped CaF{sub 2}, and Tl-doped CsI crystals were first irradiated with 6.52-keV protons to determine the effects of radiation damage on their fluorescence emission properties. For such a low-energy proton beam, only the quartz was found to be a suitable fluorescent material, since the other materials suffered a decay in fluorescence intensity with irradiation time. Subsequently, quartz was irradiated with heavy {sup 12}C{sup 4+}, {sup 16}O{sup 4+}, and {sup 40}Ar{sup 11+} ions, but it was found that the fluorescence intensity decreased too rapidly to measure the emittance of these heavy-ion beams. These results suggest that a different energy loss mechanism occurs for heavier ions and for protons. ...
Scientists of the Physikalisch-Technische Bundesanstalt (PTB) have established an experiment for the more exact determination of the stopping power of tissue for carbon ions in the therapeutically relevant area. The method works and can, in future, contribute to clearly improving the dosing for cancer therapy with carbon ions.
Dr. Dara Kraitchman is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. Her research focuses on non-...
Jan Fritz, M.D. - Dr. Fritz is an Assistant Professor of Radiology and Radiological Sciences at The Johns Hopkins University and The Johns Hopkins...
Evaluation and Comparison of Contrast to Noise Ratio and Signal to Noise Ratio According to Change of Reconstruction on Breast PET/CT. Jea-Young Lee, Eul-Kyu Lee, Ki-Won Kim, Hoi-Woun Jeong, Kwang-Yeul Lyu, Hoon-Hee Park, Jin-Hyun Son, Jung-Whan Min. Journal of Radiological Science and Technology :: Vol.40 No.1 pp.79-85. DOI:https://doi.org/10.17946/JRST.2017.40.1.12 ...
Tel:+81-(0)298-36-5264; Fax:+81-(0)298-36-9010. In this paper we focused on the production and screening of recessive fetal phenotypes by heavy ion beams. Males of C57BL/6J (B6) strain mice were anesthetized, held on a plastic plate and irradiated with C, N, and Ne ion beams at dosages of 3 and 5 Gy. The exposure to the heavy ion beams was restricted to the inguinal region of the body. Six weeks later successful irradiation of the testes was indicated by coat color changes in the ventral and dorsal skin. Histological study on testis tissues indicated that germ cells in seminiferous epithelium were significantly affected with C, N, and Ne ion beams at 3-5 Gy. Following the sterile periods, some male mice could restart reproduction. These irradiated G0 males were crossed with nonirradiated females to create G1 founders. Subsequently, the G1 founders were crossed with females to produce G2 females, half of which were heterozygous for the newly induced mutations inherited from the G1 founders. Then, ...
0184] The following list is in the approximate order in which the processes occur during generation of an Ignitor Pulse: [0185] 1. From a closely-packed array of ion sources, generate a time-sequenced series of separate beams of a specific set of ion species in individual parallel channels. The set of heavy ion species may comprise isotopes of the same atomic element or a combination of atomic elements. [0186] 2. Accelerate the multiple beams from the source array in a HVDC structure with: the same array of parallel channels and close-coupled to the ion sources to maximize beam brightness. [0187] 3. Capture the DC beam in the RF fields of a radiofrequency quadrupole accelerator (RFQ) which: 1. Is integrated with and close-coupled to the HVDC accelerating structure, 2. Converts the time-sequenced DC pulses of the isotopic beams in parallel channels into trains (called a macropulses) of micropulses at the RF frequency and 3. Further accelerates the ions to facilitate beam transport using ...
Constraining relativistic models through heavy ion collisions - High Energy Physics - Phenomenology. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Nuclear reactions at energies near and below the Coulomb barrier have found much interest since unexpectedly large cross sections of fusion for heavy ions were discovered around 1980. This book covers
H13 Mouse Mutagenesis by Heavy Ion Beams: Detection of Mutant Mice by Random Amplified Polymorphic DNA (RAPD). Teruyo Tsukada, Mio Furutsu, Aya Kogiso, Hirotake Yamaguchi, Yukiko Kitasaka, Masayo Kojima, Noriko Hiraiwa, Atsushi Yoshiki and Moriaki Kusakabe. Division of Experimental Animal Research, The Center for Biogenic Resources, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan. Mouse mutants are a quite useful animal model to study the gene functions and pathogenesis of human diseases. However, we do not have enough kinds of mutants with phenotypes that reveal functions of all the genes. For this reason, we need more effort to create and find new phenotypes in mouse mutagenesis. We would like to report an application of heavy ion beams for mouse mutagenesis. However, to analyze mutations by observing phenotypes is very hard to classify in heterozygous state, because many mutations do not appear with any abnormal phenotypes in ...
The clinical significance of carbon-ion radiotherapy (CIRT) for octogenarians with locally advanced non-small-cell lung cancer (LA-NSCLC) remains unclear.
Beam tracking is one of the options to treat tumors that are subject to respiratory motion with scanned ion beams. The presented data demonstrate that beam tracking is a feasible and accurate motion mitigation technique.. Small deviations between data from tracking and stationary reference irradiations most likely result from the experimental setup accuracy and the precision of the detector systems. In case of the cell survival experiments, the latter is dominating due to the complex cell processing procedure, including several cell handling steps, and the inherent biological variability. A large deviation in data points is observed in the survival points at +13.5 mm (Fig. 5), but this could be due to the limited statistical power of these experiments (3 independent experiments only). Concerning modeling of biological effects that have to be considered for heavy ion irradiation such as carbon beams the accuracy of the local-effect model for the primary beam and its fragments in the therapy ...
Abstract: Localized dose delivery techniques to establish a brain radiation necrosis model are described. An irradiation field was designed by using accelerated protons or helium ions with a spread-out Bragg peak. Measurement of the designed field confirmed that a high dose can be confined to a local volume of an animal brain. The irradiation techniques described here are very useful for establishing a necrosis model without existence of extraneous complications.. ...
Introduction: Highly precise irradiation using carbon-12 (12C) ions is a new means for catheter-free ablation. Besides energy deposition leading to the dose distribution, nuclear interactions lead to by-product β+-activity that can be measured using positron-emission-tomography (PET).. Hypothesis: In-beam PET scanning during focused myocardial irradiation using 12C can adequately depict 12C dose deposition.. Methods: Pigs were irradiated with 25, 40, and 55 Gy for AV node (AVN), LA-PV junction, and local LV freewall ablations. PET measurement was performed by means of a double head camera system installed at irradiation site. Coincidences were captured in end-expiration during beam extraction pauses of the accelerator.. Results: Evaluation of PET images was qualitatively performed using the coronal plane of the activity distribution superimposed on the contrast-CT in the center of the target contour. Strong β+-activities were measured in AVN and LV ablations. In AVN ablations, activity was ...
TY - JOUR. T1 - Ion beam induced liquid crystal alignment properties of 4-alkylphenoxymethyl-substituted polystyrenes. AU - Kang, Hyo. AU - Hwang, Byoung Har. AU - Baik, Hong Koo. AU - Kang, Daeseung. AU - Lee, Jong Chan. PY - 2010/2/1. Y1 - 2010/2/1. N2 - The pretilt angles of liquid crystals (LCs) can be controlled over the range 0° to 90° using ion beam treated 4-alkylphenoxymethyl-substituted polystyrene films as alignment layers, where the alkyl group is -(CH2)nH (n = 1, 2 or 4), by changing the ion beam irradiation time, incidence angle and energy. In general, LC cells made using a polymer film with a longer irradiation time, higher irradiation incidence angle with respect to the planar direction and higher irradiation energy exhibited lower pretilt angles relative to the planar direction. Furthermore, the LC cells produced using polymer films containing longer alkyl groups and a higher molar content of 4-alkylphenoxymethyl side groups exhibited greater pretilt angles under similar ...
Author: Bassler, N. et al.; Genre: Journal Article; Published in Print: 2010-04; Title: Comparison of optimized single and multifield irradiation plans of antiproton, proton and carbon ion beams
TY - JOUR. T1 - Self-healing capacity of nuclear glass observed by NMR spectroscopy. AU - Charpentier, Thibault. AU - Martel, Laura. AU - Mir, Anamul H.. AU - Somers, Joseph. AU - Jégou, Christophe. AU - Peuget, Sylvain. PY - 2016/5/5. Y1 - 2016/5/5. N2 - Safe management of high level nuclear waste is a worldwide significant issue for which vitrification has been selected by many countries. There exists a crucial need for improving our understanding of the ageing of the glass under irradiation. While external irradiation by ions provides a rapid simulation of damage induced by alpha decays, short lived actinide doping is more representative of the reality. Here, we report radiological NMR experiments to compare the damage in International Simplified Glass (ISG) when irradiated by these two methods. In the 0.1 mole percent 244Cm doped glass, accumulation of high alpha decay only shows small modifications of the local structure, in sharp contrast to heavy ion irradiation. These results reveal the ...
At IMRT many differently shaped radiation fields are used sometimes very narrow where the radiation field consists of a relatively large penumbra region. In these cases the dose calculations are complicated and might be inaccurate. Therefore the linear response over a wide dose range for the lithium formate dosemeters is an advantage for the dosedeterminations over very narrow radiation fields including the penumbra region.. Steep dose gradients are also typical in brachy therapy and the EPR dosimeters have shown to be very useful with high precision and reproducibility when dose distributions are verified in a phantom around a 192Ir source stepped forward along an applicator. Brachyterapi is usually performed with sources with gamma energies in the region 30-400 keV. Photons from these sources are generating electrons with higher LET than those in the calibration fields we normally use, 4 MV accelerator photons. This means that we have to know the LET dependence of the dosimeters. The LET ...
There are online programs for radiology science technicians to earn a bachelors degree in radiological science, or those already certified in radiological science to earn an associates degree in radiology science. There are a number of online programs available in the radiology field, lets take a look at an online radiology bachelor degree.
Co-Investigators, University of Michigan: Natasha Andronova, Atmospheric, Oceanic and Space Sciences Krzysztof J. Fidkowski, Aerospace Engineering Bruce Fryxell, Atmospheric, Oceanic and Space Sciences Tamas I. Gombosi, Atmospheric, Oceanic and Space Sciences Smadar Karni, Mathematics Carolyn C. Kuranz, Atmospheric, Oceanic and Space Sciences Edward W. Larsen, Nuclear Engineering and Radiological Sciences William R. Martin, Nuclear Engineering and Radiological Sciences Eric Myra, Atmospheric, Oceanic and Space Sciences Vijayan Nair, Statistics Philip I. Roe, Aerospace Engineering Igor Sokolov, Atmospheric, Oceanic and Space Sciences Katsuyo Thornton, Materials Science and Engineering Ben Torralva, Materials Science and Engineerin Gabor Toth, Atmospheric, Oceanic and Space Sciences Bartholomeus van der Holst, Atmospheric, Oceanic and Space Sciences Bram van Leer, Aerospace Engineering
Targets of (12)C, (59)Co, (89)Y, (197)Au and (238)U were bombarded by 2.1 GeV/A (1)H, (12)C and (20)Ne projectiles using the SuperHILAC and BEVATRON facilities at Lawrence Berkeley Laboratory (LBL). The beam flux was calculated by monitoring the decay of (11)C produced from the (12)C(projectile,projectile n)(11)C reaction. Residual gamma-ray activity from the Co, Y, Au and U targets was collected in order to trace the decay of several reaction products. The experiment focused on the calculation of cross sections for the formation of products with one neutron removed from the various target nuclei. Corrections to the saturation activity of each product were made for detector efficiency, gamma-ray absorption in the target, gamma-ray branching, beam geometry and secondary reactions;These data are shown to be inconsistent with a geometrical form given by;(sigma) (PROPORTIONAL) (A(,p)(1/3) + A(,t)(1/3) - b);where b is a universal constant. In fact the data indicates the b = A(,t)(1/3). Instead
ABSTRACT This study examines the effects of low dose x-rays on the pH, sperm count, and sperm motility of the epididymal sperm cells of wistar rats. An experimental survey (case control study design) was adopted and a purposive sampling technique was used to select the species of mammals used for the experiment while a convenient sampling technique was used to select a nearby animal farm and a simple random technique was used to select the population of the male rats used. The population.... ...
To investigate the signal factor and its function in the medium-mediated bystander effect during heavy-ion irradiation of human salivary gland (HSG) neoplastic
Additionally to having an API key associated with your account, exporting private event information requires the usage of a persistent signature. This enables API URLs which do not expire after a few minutes so while the setting is active, anyone in possession of the link provided can access the information. Due to this, it is extremely important that you keep these links private and for your use only. If you think someone else may have acquired access to a link using this key in the future, you must immediately create a new key pair on the My Profile page under the HTTP API and update the iCalendar links afterwards ...
El Archivo Digital UPM alberga en formato digital la documentacion academica y cientifica (tesis, pfc, articulos, etc..) generada en la Universidad Politecnica de Madrid.Los documentos del Archivo Digital UPM son recuperables desde buscadores: Google, Google Academics, Yahoo, Scirus, etc y desde recolectores OAI: E-ciencia, DRRD, Recolecta (REBIUN-FECYT), Driver, Oaister, etc.
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. How could we overcome the resistance of hepatocellular carcinoma against chemotherapeutics? Question 68. Is pursuit of non-covalent small-molecule binders of RAS proteins viable as a strategy of cancer drug discovery? Question 69. In what oligomeric structures do RAS proteins signal? Question 70. How can we achieve non-invasive early detection and diagnosis of lung cancer? Question 71. Does genetic information influence the volatolome enabling diagnosis of lung cancer with genetic mutations via cell headspace or breath analysis? Question 72. Is heavy ion beam radiotherapy effective to kill cancer stem cells? Question 73. Is there any diversity among different types
Materials And Methods: A total of 21 patients who were treated with conventional passive carbon-ion beam for pancreatic cancer underwent 4DCT imaging under free-breathing conditions. We defined two types of clinical target volume (CTV) for the initial and boost irradiations: CTV1 included the gross tumor volume (GTV) and peripheral organs, and CTV2 included the GTV only with an added uniform 2-mm margin. Planning target volumes 1 and 2 (PTV1 and PTV2) were calculated by adding the range variation considered internal margin defined by 4DCT to the respective CTVs. The initial prescribed dose (=45.6Gy (RBE); RBE-weighted absorbed dose) was given to PTV1, and the boost dose was increased up to 26.4Gy (RBE) and given to PTV2. Dose assessments were compared between irradiation techniques using the paired t-test ...
Methods: Alanine detectors have been irradiated with carbon ions with an energy range of 89-400 MeV/u. The relative effectiveness of alanine has been measured in this regime. Pristine and spread out Bragg peak depth-dose curves have been measured with alanine dosimeters. The track structure based alanine response model developed by Hansen and Olsen has been implemented in the Monte Carlo code FLUKA and calculations were compared to experimental results ...
09-DEC-2017 : Conference on Rejuvenating Prosthodontics held in AMU Aligarh, December 9: The Department of. 08-DEC-2017 : AMU hosts International Ergonomics Conference Aligarh, December 8: The 15th International Ergonom. 08-DEC-2017 : AMU Vice Chancellor meets Chancellor, Syedna Mufaddal Saifuddin ALIGARH December 8: Buoyed by the r. 08-DEC-2017 : Dr Salman Shah appointed as Deputy Director, MAS ALIGARH December 8: The Vice Chancellor of Aliga. 08-DEC-2017 : World Neurocongress slated for December 9 ALIGARH December 8: The Interdisciplinary Brain Research. 08-DEC-2017 : Vigilance awareness week observed ALIGARH December 8: As part of the national vigilance awareness d. 08-DEC-2017 : Meet on Autism and other Developmental Disorders: A Clinical Approach held in JNMC Aligarh, De. 08-DEC-2017 : AMU Assistant Prof wins first prize in Basic Research Category at Kolkata Conference Aligarh, De. 08-DEC-2017 : AMU Assistant Prof attends workshop at Delhi School of Economics Aligarh, December 7: ...
A.H. Mir, I. Monnet, M. Toulemonde, S. Bouffard, C. Jegou, et al.. Mono and sequential ion irradiation induced damage formation and damage recovery in oxide glasses: Stopping power dependence of the mechanical properties. Journal of Nuclear Materials, Elsevier, 2016, 469, pp.244-250. ⟨10.1016/j.jnucmat.2015.12.004⟩. ⟨cea-02433288⟩ ...
The SPIRAL2 (Second Generation System On-Line Production of Radioactive Ions) facility will produce light and heavy exotic nuclei at high intensities by the ISOL (Isotope Separation On-Line) method.. SPIRAL2 wil continue investigations undertaken with SPIRAL1 and will provide better insight into the table of nuclides, thereby fostering the discovery of new properties of matter.. SPIRAL2 will produce deuterons (D+) beams up to 5 mA and 40 MeV, protons (H+) beams between 0.15-5 mA and 0.75 - 40 MeV and heavy ions (q/A=1/3) up to 1 mA and 14.5 MeV/nucleon. These beams will bombard different target and the resulting reactions, such as fission, transfer, fusion, ... will generate billions of new nuclei.. SPIRAL2 consists of two ECR sources (Electronic Cyclotron Resonance) to create the beam; an RF accelerating structure made of copper called radiofrequency quadrupole (RFQ) which gives the first acceleration to the beam and bunches the beam into particle buckets; the beam transport lines and the ...
In principle there are two different possibilities to study the interaction between matter. Matter can be accelerated on to each other, where it collides the interaction can be investigated. This is applied for studying the interaction between identical materials. Accelerating the material on a fixed target is the second possibility. This allows a huge amount of combinations. The various products of the interaction between the heavy-ion beam and the target matter as for example fission products, recoil particles, or compound nuclei are analysed with suitable detectors behind the target. Here, at the target laboratory, most of the targets internally needed are produced, as well as those for external experiments where people from GSI are involved. In this laboratory different processes for the production of thin films, thick films and bulk targets as well as for the surface preparation are applied, developed and improved. The main task is the production of self-supporting films over a thickness ...
To report the clinical experience of eye sparing surgery (ESS) and adjuvant carbon-ion or proton radiotherapy (CIRT or PRT) for orbital malignancies. An analysis of the retrospective data registry from the Shanghai Proton and Heavy Ion Center for patients with orbital tumors was conducted. The 2-year local progression-free, regional recurrence-free, distant metastasis-free, progression-free, and overall survival (LPFS, RRFS, DMFS, PFS, OS) rates as well as associated prognostic indicators were analyzed. Radiotherapy-induced acute and late toxicities were summarized. Between 7/2014 to 5/2018, 22 patients with orbital malignancies of various pathologies received ESS followed by CIRT (18), PRT (1), or PRT + CIRT boost (3). With a median follow-up of 20.25 (range 3.8-38.8) months, the 2-year OS, PFS, LPFS, RRFS, and DMFS rates were 100, 57.9, 92.9, 93.3, and 72.8%, respectively. No acute severe (i.e., ≥grade 3) toxicity was observed. Two patients experienced severe visual impairment as late toxicities.
Cancer treatments have markedly improved in recent decades. Surgery is considered the main treatment for primary tumors. Yet, surgery has limitations since it can be highly invasive, sometimes causing the loss of function of organs. Improvements in chemoradiotherapy are promising as this modality is less invasive and may preserve organ function. Utilizing a combination of various cancer therapies, such as surgery, radiotherapy, systemic chemotherapy and molecular targeted therapy, locoregional cancer control rates have greatly improved (1). However, relapse and metastasis, which worsen patient outcomes, are of concern. It is important to prevent cancer recurrence and metastasis as the resultant tumors are often more viable and resistant to chemoradiotherapy. The reasons for therapeutic resistant of cancer cells are controversial. However, the cancer stem cell (CSC) theory may provide an accurate explanation.. The CSC theory explains that a small population of cells in a tumor has stem cell ...
Scientists report that induced pluripotent stem cells (iPS) have a similar immune response in mice as embryonic stem cells (ES).. The scientists published their findings in the journal Nature¹. Back in 2007, scientists first reported that cells could be reprogrammed to an embryo-like state. Medical researchers wanted to use these iPS cells to create an endless supply of genetically matched replacement tissues to treat a range of diseases, from diabetes to Parkinsons.. This strategy seemed to offer a way around the ethical issues of using stem cells derived from human embryos. However, researchers started to worry about potential side effects. A 2011 study² showed that iPS cells provoked an immune response when injected into mice from which they had been derived.. The new study rejects that conclusion. Masumi Abe, a geneticist at the National Institute of Radiological Sciences in Chiba, Japan, and his team took iPS cells derived from mice and injected them back into the animals. They compared ...
Tuesday, June 9, 2009 , 1:58. Brookhaven National Lab has successfully developed a new pre-injector system, called the Electron Beam Ion Source, for the Relativistic Heavy Ion Collider (RHIC) and NASA Space Radiation Laboratory science programs. The first of several planned improvements to the RHIC facility, EBIS will help transform RHIC into the Quantum Chromo Dynamics Lab that will enable the study of QCD in more detail. EBIS Home Page. Video Tags: NASA NSRL RHIC ...
Measurements of on-shell ZZ production are described, using data collected by DELPHI in 1997 and 1998, at centre-of-mass energies roots = 182.6 GeV and 188.6 GeV, respectively. Results obtained in each of the final states q (q) over barq (q) over bar, mu (+)mu (-) q (q) over bar e(+)e(-)q (q) over bar, nu<(<nu>)over bar>q (q) over bar, l(+)l(-)l(+)l(-), and nu<(<nu>)over bar>l(+)l(-) are presented. The measured cross-sections for on-shell ZZ production via the tree-level doubly-resonant graphs (NC02) are: sigma (NC02) (182.6 GeV) = 0.38 +/- 0.18 (stat) +/- 0.04 (syst) pb, sigma (NC02) (188.6 GeV) = 0.60+/-0.13 (stat) +/- 0.07 (syst) pb. They are consistent with the Standard Model expectations of 0.25 and 0.65 pb at each energy. (C) 2001 Published by Elsevier Science B.V. RI Ragazzi, Stefano/D-2463-2009; Gonzalez Caballero, Isidro/E-7354-2010; Krammer, Manfred/A-6508-2010; Muresan, Raluca-Anca/C-3725-2011; Katsanevas, Stavros/A-4297-2011; Ruiz, Alberto/E-4473-2011; ...
Our study demonstrates that SPECT/CT imaging is well suited to dynamically track the biodistribution and movement of stem cells to both target and non-target organs, says lead investigator Dr. Dara L. Kraitchman, an associate professor of radiology at the Johns Hopkins Russell H. Morgan Department of Radiology and Radiological Science. Such a non-invasive means of studying stem cell movement could be very helpful in monitoring therapeutic safety and efficacy in clinical trials. With her co-workers, Drs. Jeff W.M. Bulte, Mark F. Pittenger, Benjamin M.W. Tsui, Randell G. Young, and Richard L. Wahl, she anticipates that this technique will useful in developing customized therapies for future patient trials ...
With increasing longevity among the population, the incidence of AD is expected to rise rapidly, creating a great burden not only for patients and their families, but also for society, said Min-Ying Su, Ph.D., author and associate professor in the Department of Radiological Sciences & the Tu and Yuen Center for Functional Onco-Imaging at the University of California at Irvine. Our methods may enable earlier diagnosis of AD, allowing earlier intervention to slow down disease progression, she added ...
Please do not make any purchases in advance. You will receive information regarding the purchase of the tablet laptop PC from the Program Director.. The field of radiological science continues to build upon an already significant use of digital images, replacing a film-based system in existence for 50 years. In fact, all of the clinical sites which Gannon students and faculty interact with are using digital capture, storage, viewing, and transmission. To ensure our Radiologic Science students graduate with the experience to use these technological advances, all students entering the program are required to have a tablet PC.. ...
The Department of Radiological Sciences, University of California, Irvine, anticipates openings for non-tenured, academic term appointments as Junior, Assistant, Associate and Full Specialist.
This graph shows the total number of publications written about Heavy Ion Radiotherapy by people in this website by year, and whether Heavy Ion Radiotherapy was a major or minor topic of these publications ...
This thesis is focused on the potential applications of ion track-etched nanopores in polymeric membranes, such as molecular separation, gating and biosensing. The nanopores are fabricated in polyethylene terephthalate (PET) membranes by heavy ion track-etching technique. Ion track technology provides the feasibility to produce membranes with nanopores of desired diameters and geometries. The characterizations of the nanopores are performed by field emission scanning electron microscopy, replica technique and conductometry measurements. Heavy ion irradiation and subsequent track-etching lead to the generation of carboxylic groups (-COOH) on the inner pore walls. At neutral pH, nanopores are cation-selective due to the presence of ionized carboxylate groups (-COO-) on the pore surface. The chemical modification of -COOH groups with amino-terminated molecules switches the surface polarity from negative to positive which in turn flipped the nanopore perm-selective behaviour. Polymeric membranes ...
Origin of the Raman mode in nanocrystalline zinc oxide in the vicinity of A(1) (LO) phonon mode induced by energetic heavy ions is reported. The evolution of this mode in the irradiated films is ascribed to the effect of disorder and the high density of lattice defects induced by irradiation. The presence of such defects is confirmed by the reduction in the intensity of E(2) (high) mode and band bending of the near band edge absorption. A softening of the evolved Raman mode with increasing in ion fluence is also observed. This softening cannot be attributed to spatial confinement of phonons, as the sizes of the crystallites are large. Therefore, it is explained in terms of the combined effects of phonon localization by lattice defects and the structural strain in the lattice induced by electronic energy loss transferred by energetic heavy ions.
He ion irradiation effects on multiwalled carbon nanotubes structure / E. M. Elsehly, N. G. Chechenin, A. V. Makunin et al. // European Physical Journal D. - 2017. - Vol. 71, no. 4. - P. 71-79. Samples of multi-walled carbon nanotubes (MWNTs) were irradiated with 80 keV He ions. Scanning electron microscopy (SEM) inspection showed that the average outer diameters of the tube decreased as a result of ion irradiation. The samples were also characterized using Raman spectrometry by analysis of the intensity of main bands in the spectra of virgin and irradiated MWNT samples. Modifications of the disorder mode (D-band) and the tangential mode (G-band) were studied as a function of irradiation fluences. Raman spectra showed that as the fluence increases, the MWNTs first show disorder due to the produced defects, and then amorphization under still higher fluence of ion irradiation. Thermal and athermal mechanisms of the radiation induced MWNTs modifications are discussed. [ DOI ...
TY - GEN. T1 - Indications of carbon ion therapy at CNAO. AU - Orecchia, Roberto. AU - Rossi, Sandro. AU - Fossati, Piero. PY - 2009. Y1 - 2009. N2 - CNAO will be a dual center capable of providing therapeutic beams of protons and carbon ions with maximum energy of 400 MeV/u. At the beginning, it will be equipped with three treatment rooms with fixed horizontal and vertical beam lines. In a subsequent phase, two more rooms with a rotating gantry are foreseen. An active spot scanning dose delivery system will be employed. Initially, 80% of the treatments will be carried out with carbon ions. All patients will be treated within clinical trials to assess carbon ion indications with an evidence-based methodology. Seven disease-specific working groups have been developed: lung tumors, liver tumors, sarcomas, head and neck tumors, central nervous system lesions, eye tumors and pediatric tumors. The last two groups will be treated mainly with protons. In the first phase, CNAO will focus on head and ...
Figure 1: Earths Magnetosphere. Serious exposure to heavy ion galactic cosmic radiation occurs in regions beyond the outer red lines emanating from Earth in the above figure. Image credit: NASA. About 99 percent of galactic cosmic radiation is comprised of single protons, electrons, and helium nuclei. There are nine times as many helium nuclei as there are electrons and ten times as many protons as there are helium nuclei. Ions heavier than helium nuclei-for example, carbon-12, oxygen-16, silicon-28, and iron-56 nuclei-make up just one percent of all galactic cosmic rays.. Even though heavy nuclei make up such a tiny percentage, they inflict more biological damage than all the other forms of galactic cosmic radiation. Another reason heavy nuclei cosmic radiation caught the attention of Kumars team is that there is no technology available, or even conceivable, to protect astronauts in a spacecraft from heavy ion radiation. Furthermore, scientists know that at least 30 percent of astronauts ...
Carbon ion radiotherapy seems to be a safe and effective modality in the management of bone and soft tissue sarcomas not eligible for surgical resection, providing good local control and offering a survival advantage without unacceptable morbidity.
PURPOSE In an effort to assess the characteristics of mutation induced by different linear energy transfer (LET) radiation in higher plants, the mutational effects of carbon-ion beams and gamma-rays were investigated in Arabidopsis. MATERIALS AND METHODS The rpsL (Escherichia coli ribosomal protein small subunit S12) transgenic Arabidopsis (Arabidopsis/rpsL) mutation detection system was adopted. Dry seeds of Arabidopsis/rpsL were irradiated with gamma-rays and 208-MeV carbon ions (208-MeV (12)C(5+)), and the mutation frequency and mutation spectrum were examined. RESULTS The frequency of mutant clones increased following irradiation with 208-MeV (12)C(5+) and gamma-rays. Mutation spectrum analysis showed that G:C to A:T transitions and |2 bp deletions/insertions were significantly induced by both 208-MeV (12)C(5+) and gamma-rays. -1 and -2 frameshift mutations were characteristic in the gamma-ray irradiated group. CONCLUSIONS 208-MeV (12)C(5+) and gamma-rays induced different intragenic mutations
Irradiation induced pulsations of reverse biased metal oxide/silicon structures. Fink, D.; Kiv, A.; Fuks, D.; Tabacnics, M.; de A. Rizutto, M.; de O. D. Silva, A.; Chandra, A.; Golovanov, V.; Ivanovskaya, M.; Khirunenko, L. // Applied Physics Letters;8/20/2007, Vol. 91 Issue 8, p083512 Specific electronic features have been found in structures consisting of metal oxide layers on silicon substrates upon swift heavy ion irradiation. These features are linked to the appearance of radiation-induced negative differential resistances in the structures. In the reversed bias direction... ...
Treatment with novel radiotherapeutic technologies could increase local control in adenoid cystic carcinoma of the head and neck. Especially combined treatment with intensity-modulated radiation therapy and heavy ion (C12) boost to the primary tumor or previous tumor bed could be established as the treatment of choice in this disease.. Unfortunately, therapeutic results in the treatment of adenoid cystic carcinoma are still hampered by the occurrence of distant metastases (predominantly in the lungs) which, though progressing comparatively slowly, still limit the patients life expectancy. Most adenoid cystic carcinomas (, 80%) though, exhibit over-expression of EGFR receptors and hence provide an approach for systemic treatment. In this prospective phase II trial, the application of the EGFR antibody cetuximab will be evaluated in combination with the established treatment of intensity-modulated radiation therapy plus C12 heavy ion boost.. The trial aims at evaluation of toxicity and ...
Treatment with novel radiotherapeutic technologies could increase local control in adenoid cystic carcinoma of the head and neck. Especially combined treatment with intensity-modulated radiation therapy and heavy ion (C12) boost to the primary tumor or previous tumor bed could be established as the treatment of choice in this disease.. Unfortunately, therapeutic results in the treatment of adenoid cystic carcinoma are still hampered by the occurrence of distant metastases (predominantly in the lungs) which, though progressing comparatively slowly, still limit the patients life expectancy. Most adenoid cystic carcinomas (, 80%) though, exhibit over-expression of EGFR receptors and hence provide an approach for systemic treatment. In this prospective phase II trial, the application of the EGFR antibody cetuximab will be evaluated in combination with the established treatment of intensity-modulated radiation therapy plus C12 heavy ion boost.. The trial aims at evaluation of toxicity and ...
From the Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC.. Received for publication August 23, 2018; and accepted for publication, after revision, August 25, 2018.. Conflicts of interest and sources of funding: none declared.. Correspondence to: Donna R. Roberts, MD, Department of Radiology and Radiological Science, 96 Jonathan Lucas St, Medical University of South Carolina, Charleston, SC 29425. E-mail: [email protected].. ...
Heavy particle expansions, familiar from heavy quark physics, have found important applications in the analysis of dark matter candidates and their interactions with the Standard Model. From a different direction, precision spectroscopy of muonic hydrogen has challenged QED and required more precise knowledge of proton structure. These problems have forced a closer examination of the construction of general heavy particle lagrangians at high orders in the 1/M expansion, and in the absence of known ultraviolet
Highly dense CaMn1-xRexO3 (0 ≤ x ≤ 0.04) samples were prepared by solid-state synthesis. The effect of Re doping was assessed by the characterisation of crystal structure, oxygen content, and electrical and thermal transport properties. The oxidation state of the substituted Re was determined by X-ray absorption near edge spectra to be Re(7+), and led to expansion of the lattice and an increase in electron carrier concentration due to the formation of Mn(3+). The thermal behaviour of the electrical conductivity and the thermopower over a wide temperature range allowed identification of different conduction mechanisms: (1) below 110 K, 3D variable range hopping, (2) between 110 and 650 K, small polaron transport, and (3) above 650 K, activation of carriers over a mobility edge ...
Wavelet analyses using parallel computing for plasma turbulence studies. Fujisawa, A.; Shimizu, A.; Itoh, K.; Nagashima, Y.; Yamada, T.; Inagaki, S.; Matsuoka, K.; Itoh, S.-I. // Physics of Plasmas;Oct2010, Vol. 17 Issue 10, p104503 The wavelet analyses have been carried out, using a cluster of personal computer, on the signal of electric field fluctuations measured with heavy ion beam probes in the compact helical system stellarator. The results have revealed the intermittent characteristics of turbulence and of the... ...
A 55-year-old female presented with abnormal vaginal bleeding and was diagnosed with FIGO Stage IIA (T2aN0M0, UICC 6th edition) squamous cell carcinoma of the uterine cervix. The patient had an elevated value of serum squamous cell carcinoma antigen (SCC), 5.3 ng/ml (normal value: 0-1.5 ng/ml). The patient was treated with external beam RT (EBRT) of 50 Gy in 25 fractions to the pelvis using conventional X-rays (consisting of 26 Gy of whole pelvis fields and the last 24 Gy of center shielding pelvis fields) and 4 fractions of high-dose-rate (HDR) intracavitary brachytherapy (BT) with the total dose of 24 Gy given to point A. There were no acute adverse effects greater than Grade 3. However, there were Grade 2 upper gastrointestinal symptoms and Grade 1 neutropenia. The tumor completely disappeared, and the serum SCC levels returned to normal after therapy. Therefore, the patient received no further treatment. Twenty-three months later, the patient developed bilateral edema in the legs. A ...
TY - JOUR. T1 - Numerical Model Simulating the Therapeutic Electron Beam of a Clinical Linear Accelerator. AU - Miloichikova, I. A.. AU - Gavrikov, B. M.. AU - Krasnykh, A. A.. AU - Cherepennikov, Yu M.. AU - Stuchebrov, S. G.. PY - 2020/1/1. Y1 - 2020/1/1. N2 - We present here the results of developing a numerical model of therapeutic electron beams from a clinical accelerator, which is required to solve the task of defining the transverse profile of the fields intended for radiotherapy procedures. We describe a model of an electron source with typical main elements of medical accelerators, including a standard applicator used for forming the beam profile. The model was shown to be sufficiently accurate by comparing the calculated data for the electron beam depth dose distribution in water with the results of experiments obtained using a medical accelerator.. AB - We present here the results of developing a numerical model of therapeutic electron beams from a clinical accelerator, which is ...
Milosavljevic, M, Perusko, D, Milinovic, V, Stojanovic, Z, Zalar, A, Kovac, J and Jeynes, C (2010) Ion irradiation stability of multilayered AlN/TiN nanocomposites ...
Japanese Journal of Clinical Oncology Advance Access published July 13, 2012A Review of Update Clinical Results of Carbon Ion RadiotherapyHirohiko Tsujii* and Tadashi Kamada, Research Center for Charged Particle Therapy, National Institute ...
After its discovery by Lewis Stadler at the University of Missouri, irradiation of seed and plant germplasm has resulted in creating many widely-grown cultivars of food crops worldwide.[6] The process, which consists of striking plant seeds or germplasm with radiation in the form of X-rays, UV waves, heavy-ion beams, or gamma rays, essentially mixes the genes already existing in the genome. The UN has been an active participant through the International Atomic Energy Agency. Irradiation is also employed to prevent the sprouting of certain cereals, onions, potatoes and garlic.[7] Appropriate irradiation doses are also used to produce insects for use in the sterile insect technique of pest control.[8] ...
ICD-10-PCS code D7004ZZ for Beam Radiation of Bone Marrow using Heavy Particles (Protons,Ions) is a medical classification as listed by WHO under the
A search for new heavy particles that decay into top-quark pairs is performed using data collected from proton-proton collisions at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. The integrated luminosity of the data sample is 36.1 fb(-1). Events consistent with top-quark pair production are selected by requiring a single isolated charged lepton, missing transverse momentum and jet activity compatible with a hadronic top-quark decay. Jets identified as likely to contain b-hadrons are required to reduce the background from other Standard Model processes. The invariant mass spectrum of the candidate top-quark pairs is examined for local excesses above the background expectation. No significant deviations from the Standard Model predictions are found. Exclusion limits are set on the production cross-section times branching ratio for hypothetical Z bosons, Kaluza-Kein gluons and Kaluza-Klein gravitons that decay into top-quark pairs.. ...
The intrinsic optical torque of a focused cylindrical vector beam on a Rayleigh absorptive spherical particle is calculated via the corrected dipole approximation. Numerical results show that, for the radially polarized input field, the torque is distributed in the focal plane strictly along the azimuthal direction anywhere except at the focus. This shows a completely different property from what is observed in the focusing of a circularly polarized beam, where a strong axial torque component arises. For other cylindrically polarized input fields, the torque tends to align itself along the radial direction, as the polarization angle (the angle between the electric vector and the radial direction) changes from 0° to 90°. When limited to considering the torque at the equilibrium position, we find that only for those input fields with polarization angles larger than 50°, the particle experiences a nonzero torque at its equilibrium position. This is verified by showing quantitatively the effects ...
TY - JOUR. T1 - Kinetics of chromosome rejoining in normal human fibroblasts after exposure to low- and high-LET radiations. AU - Loucas, B. D.. AU - Geard, C. R.. PY - 1994. Y1 - 1994. N2 - To determine whether chromosome breaks produced by α particles are processed differently from those produced by X rays, the premature chromosome condensation technique was used to follow chromosome rejoining after irradiation. Doses of 90 and 200 keV/μm α particles (2.7 Gy) and 250 kVp X rays (6 Gy) were chosen to produce approximately the same number of initial chromosome breaks (about 30 excess fragments per cell). Frequencies of excess fragments were assessed at eight times to 24 h after irradiation with the final yields being about 2, 4 and 8 excess fragments per cell for 250 kVp X rays and 200 and 90 keV/μm α particles, respectively. For each radiation the time for the initial measured fragment frequency per cell to be halved (i.e. to about 15) was the same (about 100 min). The results were fitted ...
Electrostatic accelerators are an important and widespread subgroup within the broad spectrum of modern, large particle acceleration devices. They are specifically designed for applications that require high-quality ion beams in terms of energy stability and emittance at comparatively low energies (a few MeV). Their ability to accelerate virtually any kind of ion over a continuously tunable range of energies makes them a highly versatile tool for investigations in many research fields including, but not limited to, atomic and nuclear spectroscopy, heavy ion reactions, accelerator mass spectroscopy as well as ion-beam analysis and modification. The book is divided into three parts. The first part concisely introduces the field of accelerator technology and techniques that emphasize their major modern applications. The second part treats the electrostatic accelerator per se: its construction and operational principles as well as its maintenance. The third part covers all relevant applications in which
Clinicians have long hoped that charged particle therapy, such as protons and carbon ions, would improve the local control of tumors while sparing adjacent normal structures from unnecessary radiation. Protons and carbon ions exhibit a defined Bragg peak of ionization.40 The proton or carbon ion dose in front of the peak is notably lower, with a very pronounced and rapid falloff of dose after the peak, whereas the megavoltage photon-based therapy (as used in IMRT) and neutrons do not have this unique property.11 Photon beams deliver relatively higher doses of falloff radiation along the beam path, whereas protons or carbon ions stop following the peak. The proton or carbon ion beam energy can be modulated so that the peak is sustained at all of the desired depths of penetration across the tumor while minimizing the dose to the immediately adjacent normal tissue. This is accomplished by using a scattered broad beam, with range modulation and a range compensator that conforms the dose to the ...
Clinicians have long hoped that charged particle therapy, such as protons and carbon ions, would improve the local control of tumors while sparing adjacent normal structures from unnecessary radiation. Protons and carbon ions exhibit a defined Bragg peak of ionization.40 The proton or carbon ion dose in front of the peak is notably lower, with a very pronounced and rapid falloff of dose after the peak, whereas the megavoltage photon-based therapy (as used in IMRT) and neutrons do not have this unique property.11 Photon beams deliver relatively higher doses of falloff radiation along the beam path, whereas protons or carbon ions stop following the peak. The proton or carbon ion beam energy can be modulated so that the peak is sustained at all of the desired depths of penetration across the tumor while minimizing the dose to the immediately adjacent normal tissue. This is accomplished by using a scattered broad beam, with range modulation and a range compensator that conforms the dose to the ...
National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-City, Chiba 263-8555, Japan; †Department of Applied Physics, National Defense Academy of Japan, 1-10-20 Hashirimizu, Yokosuka-City, Kanagawa 239-8686, Japan; ‡Department of Radiation Physics and Chemistry, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima-City, Fukushima 960-1295, Japan; §Department of Human Care, Tohto College of Health Sciences, 4-2-11 Kamishiba-cho Nishi, Fukaya-City, Saitama 366-0052, Japan ...
The Department of Radiology and Radiological Science is an academic department within the College of Medicine at the Medical University of South Carolina. Our department has a long tradition of excellence in both clinical and educational activities. We are guided by the mission of MUSC to maintain excellence in education, research and service.. The department has one of the most advanced diagnostic imaging facilities in the country ranging from conventional radiography to dual source multi-detector CT, twin beam PET/CT, 3 Tesla large bore MRI, ...
Evaluation of the increase in permeability of the blood–brain barrier during tumor progression after pulsed focused ultrasound Feng-Yi Yang1,*, Hsin-Ell Wang1,*, Guan-Liang Lin1, Hui-Hsien Lin1, Tai-Tong Wong21Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, 2Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan *These authors contributed equally to this workPurpose: The purpose of this study was to evaluate the permeability of the blood–brain barrier after sonication by pulsed high-intensity focused ultrasound and to determine if such an approach increases the tumor:ipsilateral brain permeability ratio.Materials and methods: F98 glioma-bearing Fischer 344 rats were injected intravenously with Evans blue with or without blood–tumor barrier disruption induced by transcranial pulsed high-intensity focused ultrasound. Sonication was applied at a frequency
Industrial collaborators: Lundbeck A/S and Visiopharm Hørsholm Denmark.. International collaborators. The Lieber Institute for Brain Development, NIH, Baltimore.. Division of Medical and Radiological Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh (Prof. N. Roberts).. Department of Psychology, Institute of Neuroscience, University of Almeria, Spain.. Neurobiological and Genetic Basis of Mental and Neurological Diseases Group, Institute of Neuroscience, Autonomous University of Barcelona.. Department of Physiology and Biophysics, Virginia Commonwealth University (VCU) Health, Richmond (Javier Gonzalez-Maeso ...
Dr. John Jeffrey Carr is the Cornelius Vanderbilt Professor of Radiology and Radiological Sciences and Professor of Biomedical Informatics and Cardiovascular Medicine. Clinically, he specializes in non-invasive cardiovascular imaging computed tomography (CT) and magnetic resonance imaging (MRI). He is a physician-scientist using non-invasive imaging to not only identify and predict disease before it becomes clinical evident. Dr. Carrs research is focused on developing quantitative imaging phenotypes and biomarkers applicable to population-based and personalized medicine. His current research is using advanced computed tomography (CT) techniques to measure coronary blood vessels, coronary plaque and the surrounding pericardial adipose tissue (fat cells) as a means to better understand who is at highest risk for myocardial infarction (heart attacks) and heart failure later in life (NIH-NHLBI 7R01HL098445-05). This project is part of the NHLBI Coronary Artery Risk Development in Young Adults Study
Neurotree: mentors, trainees, research areas and affiliations for Heinrich Schelbert, Pharmacology and Radiological Sciences, UCLA School of Medicine
Laser-plasma interactions in the novel regime of relativistically-induced transparency have been harnessed to generate efficiently intense ion beams with average energies exceeding 10 MeV/nucleon (\textgreater 100 MeV for protons) at table-top scales. We have discovered and utilized a self-organizing scheme that exploits persisting self-generated plasma electric (\textasciitilde 0.1 TV/m) and magnetic (\textasciitilde 10$^{\mathrm{4}}$ Tesla) fields to reduce the ion-energy ($E_{\mathrm{i}})$ spread after the laser exits the plasma [1], thus separating acceleration from spread reduction. In this way we routinely generate aluminum and carbon beams with narrow spectral peaks at $E_{\mathrm{i}}$ up to 310 MeV and 220 MeV, respectively, with high efficiency ($\approx$ 5{\%}). The experimental demonstration has been done at the LANL Trident laser with 0.12 PW, high-contrast, 0.65 ps Gaussian laser pulses irradiating planar foils up to 250 nm thick. In this regime, $E_{\mathrm{i}}$ scales ...