Radiation therapy for head and neck neoplasms , Radiation therapy for head and neck neoplasms , کتابخانه دیجیتال دانشگاه علوم پزشکی اصفهان
Treatment with the immune-stimulating agent, Keytruda® (pembrolizumab), provides impressive long-term outcomes for some patients with metastatic or recurrent head and neck cancer. These results were recently presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO).. Globally, head and neck cancer comprises the seventh most common type of cancer with an estimated 400,000-600,000 diagnoses every year. Head and neck squamous cell cancer (HNSCC) refers to head and neck cancer that originates in certain cells called squamous cells.. Metastatic or stage IV head and neck cancer refers to cancer that has spread from its site of origin to distant sites in the body. Overall survival at 5 years for patients diagnosed with metastatic head and neck cancer has remained at less than 4%, indicating a significant need in improved treatment for patients with this disease. Recurrent head and neck cancer refers to cancer that has recurred or progressed despite prior ...
Read about Narrow Band Imaging (NBI), a new endoscopic, diagnostic technique for detection of Head & neck cancer in aerodigestive tract, provided at Sakra world Hospital.
A Multidisciplinary Approach to Head and Neck Neoplasms is a comprehensive how-to guide that addresses the medical and surgical treatment of the most common and challenging neoplasms in head and neck surgery. It takes a hands-on approach to describing the latest surgical techniques, including intraoperative navigation, robotic surgery, image guidance for sinus tumors, and endoscopic skull base procedures. This book will be the reference of choice for residents and fellows, experienced otolaryngologists, and head and neck surgeons ...
Most types of head and neck cancer develop in the lining of cells found within many parts of the head and neck. Each year, more than 40,000 adults are diagnosed with head and neck cancer in the United States. The leading cause of this type of cancer is tobacco use. Common signs and symptoms of head and neck cancer include blood in saliva; frequent nose bleeds; and difficulty chewing, swallowing, or breathing. Effective treatments for head and neck cancer are available if the cancer is found in its early stages. However, treatment is difficult, causing many people to become depressed within 3 months of being diagnosed. Unfortunately, depression can lead to delays in treatment, impair quality of life, and decrease long-term survival. The purpose of this study is to determine whether the use of antidepressant medication initiated prior to starting treatment will prevent the onset of depression during treatment in non-depressed head and neck cancer patients. This study will also determine if ...
Introduction. Worldwide, more than 550,000 cases and 380,000 deaths occur annually from head and neck squamous cell carcinoma (HNSCC).1 In the United States, 63,000 patients are diagnosed annually, and about 13,000 die from the disease.2 The majority are related to tobacco and alcohol use, but the number of high-risk human papillomavirus (HPV)-associated oropharynx cancers is increasing; these are often identified in clinical trials via staining for the surrogate marker p16. Tumors that are p16-positive (+) have a more favorable prognosis and may require less intense treatment.3,4. Patients with HPV-associated cancers are significantly younger, have tumors typically in the tonsillar region or base of tongue, and tend to present with early-stage primary tumors with an increased risk of advanced nodal involvement when compared with HPV-negative (-) patients.5 HPV-associated tumors are pathologically distinct, with lymphocyte infiltration in the stroma and in tumor nests.6 Despite advances in ...
Background: Neurobehavioral functions and quality of life (QoL) are the important outcome measurements after radiotherapy in patients with brain tumors and even head/neck cancers. However, few studies have focused on neurobehavioral functions and QoL after anti-cancer treatment particularly brain radiotherapy for pediatric/adolescent patients with brain tumors. This study thus aims to prospectively evaluate those functions in pediatric or adolescent patients with brain or head/neck tumors in order to provide useful information about their clinical outcomes.. Methods: A total of 72 pediatric/adolescent patients, who are diagnosed with brain tumors or head/neck cancers, were prospectively recruited. Neurobehavioral functions will be evaluated using a neuropsychological battery, which includes general cognitive functions, intelligence, memory, executive functions, information processing and emotional/behavioral expressions. The QoL will be evaluated by the health-related QoL questionnaire. All ...
TY - JOUR. T1 - Non-squamous variants of human papillomavirus-related head and neck carcinoma. AU - Bishop, Justin A.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Human papillomavirus (HPV) is now well established as an important causative agent in a subset of head and neck cancers. HPV-related head and neck carcinomas are important to recognize because these malignancies are associated with better survival and an improved response to therapy when compared to their HPV-negative counterparts. HPV-related head and neck cancer characteristically takes the form of a non-keratinizing squamous cell carcinoma. Widespread HPV testing of head and neck tumours, however, has revealed variants that depart from the standard HPV-related squamous cell carcinoma morphology. Most recently, examples of HPV-related carcinomas that actually lack a squamous phenotype, at least partially, have been reported. This manuscript will discuss these non-squamous variants of HPV-related head and neck carcinomas: adenosquamous ...
(HealthDay)-Twenty-three percent of patients with head and neck squamous cell carcinoma (HNSCC) have cardiovascular disease (CVD) at diagnosis, and 24 percent have uncontrolled blood pressure, according to research published ...
Cherubism is a rare benign (non-neoplastic) hereditary condition of childhood, which is inherited as an autosomal dominant trait and is characterized by bilateral expansion of the mandible, maxilla or both. Giving them a characteristic cherubic appearance. The treatment of cherubism is still controversial and is said that the disease regresses itself and after regressing if any asymmetry is left then the bony deformity can be corrected by decortications of bone and osseous shaving. This article reviews the recent development in the literature of cherubism ...
Head and neck cancers are a group of biologically similar cancers originating from the upper aerodigestive tract, including the lip, mouth, nasal cavity, paranasal sinuses, pharynx and larynx that affect more than 45,000 individuals in the U.S. each year. Head and neck cancers are strongly associated with environmental and lifestyle risk factors, including tobacco smoking, alcohol consumption and certain strains of the sexually transmitted human papilloma virus.. Founded in 1984, the University of Pittsburgh Cancer Institute became a National Cancer Institute (NCI)-designated Comprehensive Cancer Center in six years. UPCI is the only cancer center in western Pennsylvania with this elite designation, serving the regions population of more than 6 million. Presently, UPCI receives a total of $154 million in research grants and is ranked 10th in NCI funding.. ...
Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons (PAH) is recognized to play an important role in the development of oral/head and neck squamous cell cancer (HNSCC). We recently reported higher levels of TSNA-associated DNA adducts in the oral cells of smokers with HNSCC as compared with cancer-free smokers. In this study, we further investigated the tobacco constituent exposures in the same smokers to better understand the potential causes for the elevated oral DNA damage in smokers with HNSCC. Subjects included cigarette smokers with HNSCC (cases, n = 30) and cancer-free smokers (controls, n = 35). At recruitment, tobacco/alcohol use questionnaires were completed, and urine and oral cell samples were obtained. Analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and N-Nitrosonornicotine (NNN; TSNA biomarkers), 1-hydroxypyrene (1-HOP, a PAH), cotinine, 3′-hydroxycotinine, and the nicotine metabolite ratio (NMR) were performed. Cases ...
The official journal of the Head & Neck Optical Diagnostics Society. Head & Neck Oncology encompasses all aspects of clinical practice, basic and ...
Oral, Head and Neck Oncology and Reconstructive Surgery is the first multidisciplinary text to provide readers with a system for managing adult head and neck cancers based upon stage. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular reconstructive surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are included, which are easily accessible on mobile devices.
PURPOSE: Mitochondrial dysfunction has been linked to defects in the apoptotic pathway, and solid tumors, including head and neck squamous cell carcinoma (HNSCC), exhibit defects in apoptosis. Loss of mitochondrial membrane potential (DeltaPsim) is a
Head and neck cancer is a group of cancers that starts within the mouth, nose, throat, larynx, sinuses, or salivary glands. Symptoms may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice. There may also be unusual bleeding, facial swelling, or trouble breathing. About 75% of head and neck cancer is due to the use of alcohol or tobacco. Other risk factors include betel quid, certain types of human papillomavirus, radiation exposure, certain workplace exposures, and Epstein-Barr virus. Head and neck cancers are most commonly of the squamous cell carcinoma type. The diagnosis is confirmed by tissue biopsy. The degree of spread may be determined by medical imaging and blood tests. Not using tobacco or alcohol can reduce the risk. While screening in the general population does not appear to be useful, screening high risk groups by examination of the throat might be useful. Often, head and neck cancer is curable if detected ...
Conference report on the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV), 24-26 February 2017, Jaipur, India Tej Prakash Soni,
Decisions about treatment for head and neck cancer are largely dependent on the site, stage, and histological characteristics of the disease. Treatment may include surgery, RT, chemotherapy, or some combination of these. RT is offered to nearly 75 percent of patients with head and neck cancer with curative or palliative intent, often with long-term side effects.. RT techniques have evolved over the past 30 years; two-dimensional images have been replaced with three-dimensional (3D) images with the intended purpose of improving effectiveness while reducing toxicity to normal tissues and adjacent vulnerable organs. Photon-based conformal external-beam RT modalities used to treat head and neck cancer include 3D conformal RT (3DCRT), intensity-modulated RT (IMRT), and stereotactic body RT (SBRT). Charged particle-based conformal external-beam RT modalities, such as proton-beam RT (PBT), are also available to treat head and neck cancer, although they are not widely available in the United ...
Objective: Head and Neck Squamous Cell Carcinoma (HNSCC) is the fifth most common cancer worldwide with five-year survival rate of 50% despite use of modern treatment modalities. We have employed a comprehensive genome-wide integrated analysis of epigenetic and transcriptional alteration in primary HNSCC tissues in order to discover novel biomarkers of this disease.. Experimental Design: A discovery cohort included 44 primary HNSCC and 25 normal mucosal samples was analyzed by Affymetrix GeneChip Human Exon 1.0 and Illumina Infinium Human Methylation 27 arrays. An independent validation cohort included 32 primary HNSCC and 15 normal mucosal samples to confirm differential methylation by bisulfate sequencing. A second validation cohort included salivary rinse and primary tissue from 59 HNSCC and 31 healthy patients. Detection of DNA methylation in bodily fluids and primary tissues from the later cohort was evaluated by quantitative methylation-specific PCR (qMSP).. Results: We have applied novel ...
Background: An association between sexually transmitted diseases (STDs) and occurrence of head and neck cancer (HNC) is proposed.Aims/objectives: We aimed to determine the association between selected STDs (syphilis, gonorrhoea, HIV) and HNC.Materials and methods: Patients diagnosed with HNC in Denmark between 1978 and 2014 identified through the Danish Cancer Registry were included. Patients were age- and sex-matched in a 1:10 ratio with general population controls. Uni- and multivariate analyses were performed using the Cox regression model to assess the correlation between STD and HNC.Results: A total of 39,405 HNC patients (63% men; 63.0 years at HNC diagnosis) and 393,238 controls were included. STD in HNC patients was 0.27%, vs. 0.11% in controls. Patients with cancer of the upper airways had a significantly higher prevalence of an STD prior to the HNC compared to controls. Most HNC patients with a prior STD (64.1%) developed the HNC within five years after the STD diagnosis.Conclusions: ...
(580) 421-6470 | Head and neck cancers are those that grow in and around the throat, larynx, nose, sinuses and mouth. The majority of these cancers are squamous cell
The two strongest risk factors for these cancers are excessive alcohol use and tobacco use. At least 75 percent of head and neck cancers are related to alcohol and tobacco use, and people who drink excessively and use tobacco - whether smoked or chewed - are at even greater risk than those who use either tobacco or alcohol alone. ...
The biggest risk factors for head and neck cancers are tobacco (both cigarettes and chewing tobacco) and alcohol, especially when used together.
Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth of several cancers in vitro and in vivo. The pre clinical activity of P276-00 in head and neck cancer and its potential mechanisms of action at molecular level are the focus of the current studies. We have investigated the anti-cancer activity of P276-00 in head and neck tumors in vitro and in vivo. Candidate gene expression profiling and cell based proteomic approaches were taken to understand the pathways affected by P276-00 treatment. It was observed that P276-00 is cytotoxic across various HNSCC cell lines with an IC50 ranging from 1.0-1.5 μmoles/L and culminated in significant cell-cycle arrest in G1/S phase followed by apoptosis. P276-00 treatment suppressed cell proliferation through inhibition of CCND1 expression, reduced phosphorylation of retinoblastoma protein and abrogative
Squamous cell carcinoma of the head and neck (SCCHN) cells can escape recognition and lysis by tumor antigen (TA)-specific cytotoxic T lymphocytes (CTL) by downregulation of antigen processing machinery (APM) components, such as the transporter associated with antigen processing (TAP)-1/2 heterodimer. APM component upregulation by interferon gamma (IFN-g) restores SCCHN cell susceptibility to lysis by CTL, but the mechanism underlying TAP1/2 downregulation in SCCHN cells is not known. Because IFN-g activates signal transducer and activator of transcription (STAT)-1, we investigated phosphorylated (p)-STAT1 as a mediator of low basal TAP1/2 expression in SCCHN cells. SCCHN cells were found to express basal total STAT1 but low to undetectable levels of pSTAT1. The association of increased pSTAT1 levels and APM components likely reflects a cause-effect relationship, since STAT1 knockdown significantly reduced both IFN-g-mediated APM component expression and TA-specific CTL recognition of IFN-g ...
Welcome to the Head and Neck Cancer group. This is a welcoming, safe place where you can meet other people who are living with head and neck cancer. Lets learn from each other and share experiences from diagnosis through treatment and coping with symptoms and recovery challenges. Im Colleen, […]
According to an article recently published in the Archives of Otolargynology - Head and Neck Surgery, patients with head and neck cancer who are undergoing chemotherapy and radiation therapy have high rates of impaired ability to swallow, causing them to suck food or liquid particles through their vocal cords (aspiration).. Head and neck cancers originate in the oral cavity (lip, mouth, and tongue), salivary glands, paranasal sinuses, and nasal cavity, pharynx (upper back part of the throat), larynx (voice box), and lymph nodes in the upper part of the neck. Worldwide, head and neck cancer is diagnosed in approximately 640,000 people annually and is responsible for approximately 350,000 deaths each year.. Chemotherapy and radiation therapy are common treatment approaches for patients with head and neck cancer. These treatments are, however, associated with side effects, some of which impair ability to swallow. When swallowing is impaired, there is a risk of aspiration, often thought of as food ...
First-line treatment with Keytruda significantly prolongs survival of patients with recurrent or metastatic head and neck squamous cell carcinoma
Head and neck cancer refers to tumors that occur in the lining of the nose, mouth (oral cancer) or throat, as well as cancers of the thyroid, parathyroid and salivary glands. Doctors also include advanced skin cancers of the head and neck (scalp, ears, face and neck) in this category of cancers. ...
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A Study to Evaluate the Potential Benefit of the Addition of BYL719 to Paclitaxel in the Treatment of Breast Cancer and Head-and-neck ...
BACKGROUND: To examine the effect of the natural antimicrobial peptide human β-defensin-3 (hBD-3), on the migration of a head and neck cancer cell line in vitro using microfabrication and soft-lithographic techniques. METHODS: TR146 cancer cells were seeded in Petri dishes with microfabricated wells for cell migration assays. Total 54 cell islands were used of various shape and size and experimental media type. Cell migration assays were analyzed in six group media: Dulbeccos modified medium (DMEM); DMEM with vascular endothelial growth factor (VEGF); Conditioned media of human embryonic kidney cells (HEK 239) expressing hBD-3 via transfected cloned pcDNA3 as CM/hBD-3; CM/hBD-3+ VEGF; conditioned medium from non-transfected HEK 239 (not expressing hBD-3) as control (CM); and the last group was CM + VEGF ...
Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Residents, fellows, and veteran practitioners in otolaryngology-head and neck surgery, radiation oncology, and medical oncology will benefit from this comprehensive reference.
Swallowing dysfunction after chemo-radiation is common, but there is no reliable evidence for how it should be managed. This pilot randomized controlled
Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: ,22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.Results: Among men, a BMI , 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23-2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among ...
Background: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: ,22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.Results: Among men, a BMI , 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23-2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among ...
Head and neck malignancies are a serious problem with ~40,000 new head and neck squamous cell cancers (HNSCC) and 13,000 deaths each year in the US alone. Despi...
The Report Recurrent Head And Neck Cancer Squamous Cell Carcinoma-Pipeline Insights, 2017 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz
Head and neck cancer refers to a group of biologically similar cancers that start in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, and larynx. 90% of head and neck cancers are squamous cell carcinomas (SCCHN), originating from the mucosal lining (epithelium) of these regions. Head and neck cancers often spread to the lymph nodes of the neck, and this is often the first sign of the disease at the time of diagnosis. Head and neck cancer is strongly associated with certain environmental and lifestyle risk factors, including tobacco smoking, alcohol consumption, UV light, particular chemicals used in certain workplaces, and certain strains of viruses, such as human papillomavirus. These cancers are frequently aggressive in their biologic behavior; patients with these types of cancer are at a higher risk of developing another cancer in the head and neck area. Head and neck cancer is highly curable if detected early, usually with some form of surgery, but radiation therapy may also ...
The aim of this course is to offer an in-depth knowledge of current MR imaging techniques for the diagnosis of head and neck lesions. The course will provide the participant with an update on fundamental and advanced sequence protocols to image the different head and neck regions. A comprehensive coverage of the MR signal of the normal tissues will give the preliminary basis for head and neck anatomy. We will focus on imaging strategies, recent developments and specific MR findings to characterise head and neck congenital, inflammatory, benign and malignant diseases. Special emphasis will be placed on differential diagnosis and on grading tumour extent. The course will provide a combination of lectures and case based interactive teaching in small groups ...
received concurrent chemotherapy arms could In conclusion, for radiochemotherapy of stage receive all 3 courses of 100 mg/m2 cisplatin.19 This III/IV head and neck cancer, the regimen includ- rate may be higher than in our series, because the ing 2 courses of fractionated cisplatin (20 mg/m2/d authors did not consider patients who needed a on radiotherapy days 1-5 and 29-33) and 5-FU reduction of the chemotherapy dose. In our study, (600 mg/m2/d on radiotherapy days 1-5 and 29- both cessation of chemotherapy and dose reduc- 33) was associated with significantly less acute tions were considered as uncompleted chemother- toxicity than 3 courses of cisplatin (100 mg/m2 on radiotherapy days 1, 22, and 43). Adding 5-FU The randomized RTOG 97-03 study compared was tolerated by group B patients, because these 3 different radiochemotherapy regimens for toxic- patients received less cisplatin and because cis- ity and outcome in 241 patients with squamous platin was fractionated. The results of this ...
Tumor hypoxia regulates many cytokines and angiogenic factors (CAF) and is associated with worse prognosis in head and neck squamous cell cancer (HNSCC). Serum CAF profiling may provide information regarding the biology of the host and tumor, prognosis, and response to therapy. We investigated 38 CAFs in HNSCC patients receiving induction therapy on a phase II trial of carboplatin, paclitaxel, and cetuximab. CAFs were measured by multiplex bead assay and enzyme-linked immunosorbent assay in 32 patients. Baseline and postinduction CAF levels were correlated with disease progression (PD) and human papilloma virus (HPV) status by Wilcoxon rank sum test. Baseline levels of eight hypoxia-regulated CAFs (the high-risk signature including vascular endothelial growth factor, interleukins 4 and 8, osteopontin, growth-related oncogene-alpha, eotaxin, granulocyte-colony stimulating factor, and stromal cell-derived factor-1alpha) were associated with subsequent PD. Elevation in ,or=6 of 8 factors was ...
Japanese version SINGAPORE/LUGANO - Novel strategies are on the way for difficult-to-treat and advanced head and neck cancer, the most heterogeneous group of malignancies which are generally associated with poor survival, and encouraging results have been presented at the first ESMO Asia 2015 Congress in Singapore. In a Phase I trial1, the immunotherapy agent pembrolizumab has shown promising antineoplastic activity in patients with heavily pretreated nasopharyngeal cancer, who currently have no effective treatment options. In a large Phase II trial, the targeted agent afatinib was effective in the second-line treatment of recurrent or metastatic squamous cell carcinoma (HNSCC) after failure with platinum-based therapy.. Incidence of some types of head and neck cancer varies substantially between Asia and Europe, to some extent limiting novel options for patients. ESMO spokesperson Dr. Lisa Licitra, chief of the Head and Neck Cancer Medical Oncology Department and head and neck research ...
You are not alone-The CancerConnect Head & Neck Cancer Community is the leading Social Media Application for Head & Neck Cancer patients and caregivers seeking information, inspiration, and support in the wake of a cancer diagnosis. With over 50,000 members the network offers patients and caregivers a thriving community to support the many ongoing needs from diagnosis to survivorship. Login or register here.. A variety of factors ultimately influence a patients decision to receive treatment of cancer. The purpose of receiving cancer treatment may be to improve symptoms through local control of the cancer, increase a patients chance of cure, or prolong a patients survival. The potential benefits of receiving cancer treatment must be carefully balanced with the potential risks of receiving cancer treatment.. The following is a general overview of the treatment of stage 0 cancer of the larynx. Circumstances unique to your situation and prognostic factors of your cancer may ultimately influence ...
Head and neck cancer has a global burden of more than 550,000 cases annually [1]. Incidence rates vary between countries due to increased rates with tobacco epidemics currently peaking in some regions while declining in others where tobacco use has peaked and is falling, and with the increasing incidence associated with human papillomavirus infection [2]. Head and neck cancers diagnosed in Australia in 2009 (3896) accounted for 3.4 % of all cancers diagnosed (114,137), with the number of head and neck cancers diagnosed increasing between 1982 (2475) to 2009 (3896). This increase is attributed to an increasing aging population [3].. The treatment for head and neck cancer is often drastic and debilitating, with surgery effecting vital functions such as swallowing and breathing, as well as speech. This frequently results in poorer patient outcomes in terms of quality of life [4] that have long term impact and require significant lifestyle and psychological adjustment by patients and families ...
HEAD AND NECK CANCERS About Head & Neck Cancers The head and neck region is an anatomically diverse area of the body that is composed of soft tissue, b
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Sex practices and lifestyle are culprits. Researchers at the Johns Hopkins Kimmel Cancer Center have teased out two distinct sets of risk factors for head and neck cancers, suggesting that there are two completely different kinds of the disease.. In the Johns Hopkins study, head and neck tumors caused by the human papillomavirus (HPV), a common sexually transmitted virus, were most often linked to certain sexual behaviors and marijuana use, rather than tobacco and alcohol. The Johns Hopkins scientists also found that people with the viral-linked cancer were younger, more likely to be white, married, college-educated and have an annual income of $50,000 or higher. By contrast, those not caused by HPV, were associated with tobacco smoking, alcohol use and poor oral hygiene, which are the behaviors most often linked to head and neck cancer.. "Our results indicate that HPV-positive and HPV-negative head and neck cancers have different risk-factor profiles and should be considered two distinct ...
A look at the following clinical trial: Phase I Trial of Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers
Purpose: Head and neck squamous cell carcinoma (HNSCC) is one of the 10 most common cancers with a 50% five-year survival rate, which has remained unchanged for the past three decades. One of the major reasons for the aggressiveness of this cancer is that HNSCCs readily metastasize to cervical lymph nodes that are abundant in the head and neck region. Hence, discovering new molecules controlling the metastatic process as well as understanding their regulation at the molecular level are essential for effective therapeutic strategies.. Experimental Design: Rab25 expression level was analyzed in HNSCC tissue microarray. We used a combination of intravital microscopy in live animals and immunofluorescence in an in vitro invasion assay to study the role of Rab25 in tumor cell migration and invasion.. Results: In this study, we identified the small GTPase Rab25 as a key regulator of HNSCC metastasis. We observed that Rab25 is downregulated in HNSCC patients. Next, we determined that reexpression of ...