Complementary DNA representing the genomic M RNA segment of the Prospect Hill (PH) Hantavirus was cloned and its nucleotide sequence determined. The PH virus M RNA segment is 3707 nucleotides in length and has a long open reading frame in the viral complementary-sense RNA with a coding capacity of 1142 amino acids. The predicted gene product of the PH virus M segment was compared with the corresponding gene products of Hantaan virus strain 76-118 (Hantaan), Sapporo rat virus strain SR-11 (SR) and Puumala virus strain Hällnäs B1 (Hällnäs). The amino acid sequence identities between the G1 and G2 proteins of PH virus and Hällnäs virus are respectively 74% and 79%. In contrast, the amino acid sequence similarities between the G1 proteins of PH virus and SR virus or Hantaan virus are only 50%. However the G2 proteins of SR and Hantaan viruses were more closely related to the G2 protein of PH virus with amino acid sequence similarities of approximately 62%. The G1 proteins of all four viruses had three
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Viruses evolve rapidly…. [A]denovirus, for example, may produce 250 000 DNA molecules in an infected cell…. Leslie Collier and John Oxford(p12) Taxonomy lies at the uneasy interface between biology and logic. L. Andrew Ball(p3) If you wanted to call one of your children home for dinner would you go into the street and shout "Homo sapiens"? Michael A. Drebot, Eric Henchal, Brian Hjelle, et al(p2468) Most medical articles describe concrete viral entities and, therefore, use the common (vernacular, informal) names of viruses (eg, cytomegalo-virus, Hantaan virus, orthopoxviruses). To indicate taxonomic groups, formal virus names are used (eg, Human herpesvirus 5, Hantaan virus, the genus Less ...
Viruses evolve rapidly…. [A]denovirus, for example, may produce 250 000 DNA molecules in an infected cell…. Leslie Collier and John Oxford(p12) Taxonomy lies at the uneasy interface between biology and logic. L. Andrew Ball(p3) If you wanted to call one of your children home for dinner would you go into the street and shout "Homo sapiens"? Michael A. Drebot, Eric Henchal, Brian Hjelle, et al(p2468) Most medical articles describe concrete viral entities and, therefore, use the common (vernacular, informal) names of viruses (eg, cytomegalo-virus, Hantaan virus, orthopoxviruses). To indicate taxonomic groups, formal virus names are used (eg, Human herpesvirus 5, Hantaan virus, the genus Less ...
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Arbidol is an antiviral treatment for influenza infection used in Russia and China. Arbidol inhibits membrane fusion. Arbidol prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cel
The four viruses that are associated with HFRS are named for the region from which they were first isolated. These viruses have different primary hosts: Apodemus agrarius (striped field mouse) for Hantaan virus, Rattus norvegicus (Norway rat) and Rattus rattus (black rat) for Seoul virus, Clethrionomys glareolus (bank vole) for Puumala virus, and Apodemus flavicollis (yellow-necked field mouse) for Dobrava virus. Hantaan virus and Dobrava virus are associated with a severe form of HFRS with an estimated mortality rate of 5% to 15%. Seoul virus causes a more moderate form of HFRS, but has a much wider world distribution than the other viruses in this group. Serologic evidence for infection with Seoul hantavirus has been found in rodents in major cities of the United States, and this virus was recently implicated in human cases of HFRS in Baltimore, Wisconsin and Illinois, and possibly other US states as well ...
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Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials
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Learn about Hemorrhagic fever with renal syndrome. What are the symptoms, the causes and how to treat this condition? What can we do to cope and prevent it
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Hantaviruses cause serious human diseases, Hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome (HPS), depending on the virus type. Currently no vaccine exists and the existing drug therapy for hantavirus infections is mainly supportive. MicroRNAs are short non-coding RNAs that regulate gene expression. They play important roles in many biological processes, including cell differentiation, development and diseases like cancer. miRNAs have also been found to be involved in viral infections. The aim of this project was to investigate the miRNA expression during Hantavirus infection, and analyze the difference in miRNA expression between pathogenic hantaviruses (Hantaan virus), non-pathogenic (Prospect Hill virus), and mock-infected cells. Aberrantly expressed miRNAs could have potential as therapeutic targets.Focus assay was used to quantify the virus, and a stay in Berlin was organized to get instructions from Dr. Rang. However, the optimization of the assay was not ...
Abstract Hantavirus antigens were detected in lung tissues of 8/113 Apodemus flavicollis and 2/17 Clethrionomys glareolus captured in 1984 in Fojnica, a region of Yugoslavia endemic for hemorrhagic fever with renal syndrome; hantavirus antigens were not detected in lung tissues from 126 other mammals collected in Fojnica. Three hantaviruses, 2 from A. flavicollis and 1 from C. glareolus, were isolated directly in Vero E6 cells and were partially characterized. The isolates from A. flavicollis, designated Fojnica virus, were antigenically similar but not identical to Hantaan virus strain 76-118, whereas the isolate from C. glareolus was antigenically indistinguishable from Puumala virus, strain Hällnäs B1. These data are consistent with previous studies that indicate the existence of at least 2 hantavirus serotypes in Yugoslavia.
To the Editor: As in many West Africa nations, vectorborne diseases represent a substantial health burden in Mali; however, beyond malaria, the incidence and etiology of many of these diseases is poorly understood. Of the estimated 14.1 million persons living in sub-Saharan Mali, ≈70% live in remote rural settings with an ecologic landscape that puts inhabitants at an increased risk for contact with rodent and arthropodborne diseases. We retrospectively analyzed serum samples for evidence of recent (IgM+) and previous (IgG+) infection with chikungunya (CHIKV), dengue (DENV), West Nile (WNV), Lassa (LASV), Crimean-Congo hemorrhagic fever (CCHFV), and Ebola (EBOV) virus, as well as Old World hantaviruses (OW-HANV) and Leptospira spp., which is regularly misdiagnosed as an acute viral infection.. We tested 376 deidentified serum samples collected from acutely ill patients who had a history of fever and hemorrhagic, diarrheal, or icteric syndromes (Technical Appendix Figure). Research on samples ...
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Amidst outrage of the Coronavirus spread, China has reported another outbreak of a deadly disease, Hantavirus.. In a report by Chinas English tabloid, Global Times, on Monday, revealed that a person from Yunnan Province died while on his way back to Shandong Province for work on a chartered bus.. He was tested positive for #hantavirus on Monday and other 32 people on bus were tested.. In a research, An orthohantavirus or Hantaviruses are a family of viruses spread mainly by rodents and can cause varied disease syndromes in people worldwide. Infection with any hantavirus can produce hantavirus disease in people.. Hantaviruses in the Americas are known as "New World" hantaviruses and may cause hantavirus pulmonary syndrome (HPS). Other hantaviruses, known as "Old World" hantaviruses, are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome (HFRS).. Each hantavirus serotype has a specific rodent host species and is spread to people via inhalation of aerosolised virus ...
Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (HFRS) or of hantavirus pulmonary syndrome (HPS), depending on the virus, which are associated with high case fatality rates. There is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein Gc, the function of which is essential for virus entry. We describe here the X-ray structures of Gc from Hantaan virus, the type species hantavirus and responsible for HFRS, both in its neutral pH, monomeric pre-fusion conformation, and in its acidic pH, trimeric post-fusion form. The structures confirm the prediction that Gc is a class II fusion protein, containing the characteristic β-sheet rich domains termed I, II and III as initially identified in the fusion proteins of arboviruses such as alpha- and flaviviruses. The structures also show a number of features of Gc
Hantaviruses are members of the Bunyaviridae family of viruses. Pathogenic hantaviruses are the etiologic agents of hemorrhagic fever with renal syndrome (HFRS), a disease principally endemic in the Old World, and hantavirus pulmonary syndrome (HPS), a disease primarily restricted to the Americas. Maporal virus (MPRLV), a recently isolated hantavirus, has been found to cause disease in hamsters that resembles HPS in humans. However, the virus has not been linked to human cases of HPS. Considerable evidence suggests that β-integrin usage mediating infection may serve to distinguish hantaviruses pathogenic to humans from nonpathogenic, but this receptor usage pattern information is not yet available for MPRLV. Although ribavirin has been shown to be effective in treating HFRS, it lacks specificity and has toxicity. Moreover, there are no effective antivirals for the treatment of HPS. Considering the above, we have investigated MPRLV 1) β-integrin-mediated mechanism of entry, 2) genetic determinants of
We describe the first, to our knowledge, cases of han-tavirus pulmonary syndrome in northeastern Argentina and eastern Paraguay. Andes and Juquitiba (JUQ) viruses were characterized. JUQV was also confirmed in 5 Oligoryzomys nigripes reservoir species from Misiones. A novel Akodon-borne genetic hantavirus lineage was detected in 1 rodent from the Biologic Reserve of Limoy ...
We isolated Andes virus (formal name: Andes virus [ANDV], a species in the genus Hantavirus), from serum of an asymptomatic 10-year-old Chilean boy who died 6 days later of hantavirus pulmonary syndrome (HPS). The serum was obtained 12 days after his grandmother died from HPS and 2 days before he became febrile. No hantavirus immunoglobulin (Ig) G or IgM antibodies were detected in the serum sample. After three blind passages, ANDV antigens were detected in Vero E6 cells by immunofluorescence assay and enzyme-linked immunosorbent assay, and ANDV RNA was detected by reverse transcription-polymerase chain reaction. A fragment of the virus genome showed 96.2% nucleotide identity with that of prototype ANDV. To our knowledge, this is the first isolation of any agent of hemorrhagic fever with HPS from a human and the first such isolation of hantavirus before symptoms of that syndrome or HPS began ...
Symptoms of HFRS usually develop within 1 to 2 weeks after exposure to infectious material, but in rare cases, they may take up to 8 weeks to develop. Initial symptoms begin suddenly and include intense headaches, back and abdominal pain, fever, chills, nausea, and blurred vision. Individuals may have flushing of the face, inflammation or redness of the eyes, or a rash. Later symptoms can include low blood pressure, acute shock, vascular leakage, and acute kidney failure, which can cause severe fluid overload. The severity of the disease varies depending upon the virus causing the infection. Hantaan and Dobrava virus infections usually cause severe symptoms, while Seoul and Puumala virus infections are usually more moderate. Complete recovery can take weeks or months.. ...
Abstract Fourteen of 3,754 U.S. Marines who participated in a joint United States-Republic of Korea training exercise during the autumn of 1986 developed hemorrhagic fever with renal syndrome (HFRS). Clinical and laboratory findings among cases included fever, headache, fatigue, gastrointestinal dysfunction, thrombocytopenia, and proteinuria. Ten individuals were hospitalized; 2 died. No subclinical infections were identified through a post-deployment screen of sera obtained from 2,053 exercise participants. Analysis of questionnaires identified no environmental, occupational, or temporal factors as risks for developing disease. However, 13 of the 14 cases occurred among individuals housed at 1 of the 2 base camps used during the exercise. This outbreak represents the largest cluster of HFRS cases among U.S. personnel in the Republic of Korea since the Korean conflict.
Rabbit polyclonal H1N1 Influenza A virus Nucleocapsid protein antibody validated for WB, ELISA, ICC/IF and tested in InfA. Immunogen corresponding to synthetic…
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Congratulations to Tammy Rice, BSN, RN, CGRN, and the Endoscopy Department at Unity Hospital for participating in the Society for Gastroenterology Nurses and Associates Prevention Champions program.. Tammy was selected as the unit champion and is helping educate staff on infection prevention, maintaining high quality control, and addressing performance improvement needs. She will serve as the unit champion for a two-year term. The team has already created four goals for one year.. Great job team!. ...
This article aims to describe the Haemorrhagic Fever with Renal Syndrome (HFRS) situation in 2005 in five neighbouring countries (Belgium, France, Germany, the Netherlands and Luxembourg) and define the most affected areas. The 2005 HFRS outbreaks in these countries were the most significant in the region since 1990, with a total of 1,114 confirmed cases. The main feature of the epidemic was the extension of the known endemic area in several of the affected countries, with the involvement of urban areas for the first time. A significant increase in the number of cases was noted for the first time in the province of Liège in Belgium and in the Jura department in France. .
Hantavirus infection is acute zoonosis clinically manifesting in two forms: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by Old World hantaviruses, and Hantavirus pulmonary syndrome (HPS), caused by New World hantaviruses. Mild form of HFRS, Nephropaia epidemica (NE), is diagnosed in Tatarstan region of Russia, while HPS is endemic in Americas. Humans become infected by inhaling virus contaminated aerosol of urine and feces. The pathogenesis of NE and HPS remains largely unknown. Endothelial cells are identified as the main target; however no cell damage due to virus replication has been documented. There is no single factor identified to explain the complexity of the NE and HPS pathogenesis; therefore, it has been suggested that cytokine storm may play crucial role in disease presentation. In order to identify the serological markers distinguishing NE and HPS, team led by Dr Svetlana Khaiboullina (University of Nevada, Reno, USA) and Prof Albert Rizvanov (Kazan Federal University, ...
Introduction: Pancreatitis is a rare complication of hemorrhagic fever with renal syndrome (HFRS). The causative agents of HFRS are hantaviruses, which belong to the genus Hantavirus, family Bunyaviridae. The purpose of this study was to evaluate cases of acute pancreatitis (AP) in patients with HFRS at the Service of Infectious Diseases, Tirana, Albania.. Methodology: In this retrospective study, clinical and laboratory data was obtained from 36 patients with confirmed HFRS, between January 2011 and December 2016. The diagnosis had been confirmed by a positive enzyme-linked immunosorbent assay (ELISA) for IgM or IgG antibodies to hantavirus.. Results: The average patient age was 39.7 ± 14.1 years with a range of 15-59 years. From 36 HFRS patients, four (11.1%) were found to have AP, all were male. Abdominal pain was the most common symptom and an increase in amylase and lipase was observed in all four patients. Abdominal computed tomography (CT) indicated pancreatitis with surrounding edema, ...
Hemorrhagic fever with renal syndrome (HFRS) and leptospirosis are seasonal rodent-borne infections in the Republic of Korea (Korea). The occurrences of HFRS and leptospirosis are influenced by climatic variability. However, few studies have examined the effects of local climatic variables on the development of these infections. The purpose of this study was to estimate the effect of climatic factors on the occurrence of HFRS and leptospirosis in Korea. Daily records on human cases of HFRS and leptospirosis between January 2001 to December 2009 were analyzed. The associations of climatic factors with these cases in high incidence provinces were estimated using the time-series method and multivariate generalized linear Poisson models with a maximal lag of 12 weeks. From 2001 to 2009, a total of 2912 HFRS and 889 leptospirosis cases were reported, with overall incidences of 0.67 and 0.21 cases per 100,000, respectively, in the study areas. The increase in minimum temperature (1 °C) at a lag of 11 weeks
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Symptoms of Seoul virus infection typically begin within 1 to 2 weeks after contact with infectious material and include fever, headache, and back pain.
Principal Investigator:YAMANOUCHI TAKAHISA, Project Period (FY):1987 - 1988, Research Category:Grant-in-Aid for Co-operative Research (A), Research Field:Laboratory animal science
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Cellular receptors and hantavirus pathogenesis.: Hantaviruses cause two potentially lethal diseases, HPS and HFRS, and both diseases result in defects in vascul
A fundraiser in aid of a multi-sensory facility for the Sunflower Chernobyl Appeal will take place this Saturday August 9. The fundraiser will take place in the Western Hotel, Prospect Hill, at 6.30pm and will have performances from Shane Warner, Cafe Minor, and Jackhammer Purr. There will also be live performance puppetry, juggling, and poetry.. ...
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Hantaviruses (Bunyaviridae family) are rodent-borne bunyaviruses that cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia. This thesis presents novel data about two European hantaviruses, Dobrava virus (DOBV) and Tula virus (TULV). DOBV is an important etiologic agent of HFRS in Europe. DOBV strains were found to be hosted by at least two different rodent species, yellow-necked mouse (Apodemus flavicollis) and striped field mouse (A. agrarius). According to their natural hosts they form the distinct genetic lineages DOBV-Af and DOBV-Aa, respectively. We have determined and analysed the complete S and M, and partial L segment nucleotide sequences of sympatrically occurring DOBV-Af and DOBV-Aa strains from Central Europe. Molecular phylogenetic analyses gave evidence for genetic reassortment in the evolution of the virus species. Moreover, we amplified a DOBV-Aa nucleotide sequence from a DOBV-seropositive HFRS patient from Germany. This is the first molecular identification of human ...
Hantaviruses (Bunyaviridae family) are rodent-borne bunyaviruses that cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia. This thesis presents novel data about two European hantaviruses, Dobrava virus (DOBV) and Tula virus (TULV). DOBV is an important etiologic agent of HFRS in Europe. DOBV strains were found to be hosted by at least two different rodent species, yellow-necked mouse (Apodemus flavicollis) and striped field mouse (A. agrarius). According to their natural hosts they form the distinct genetic lineages DOBV-Af and DOBV-Aa, respectively. We have determined and analysed the complete S and M, and partial L segment nucleotide sequences of sympatrically occurring DOBV-Af and DOBV-Aa strains from Central Europe. Molecular phylogenetic analyses gave evidence for genetic reassortment in the evolution of the virus species. Moreover, we amplified a DOBV-Aa nucleotide sequence from a DOBV-seropositive HFRS patient from Germany. This is the first molecular identification of human ...