Description of disease Vaccination, Haemophilus influenzae type B (HIB). Treatment Vaccination, Haemophilus influenzae type B (HIB). Symptoms and causes Vaccination, Haemophilus influenzae type B (HIB) Prophylaxis Vaccination, Haemophilus influenzae type B (HIB)
Non-typeable Haemophilus influenzae (NTHi) and encapsulated Haemophilus influenzae type b (Hib) were inoculated into the middle ears of Sprague-Dawley rats. Tympanic membrane (TM) status was assessed otomicroscopically and specimens from various middle ear areas were prepared for light microscopy at various times during the acute phase and up to 6 months after inoculation. Irrespective of bacteria strain, acute otitis media (AOM) was present in all ears 4 days after inoculation. The Hib-infected ears showed initially a severe course of AOM, but all were otomicroscopically resolved by day 12, at which time a few NTHi-inoculated ears still exhibited middle ear effusion. The TMs infected with Hib had normalized without scar formation, whereas NTHi induced a persistent thickening of the TMs in half of all cases. The middle ear mucosa of NTHi-infected ears initially showed vigorous activity among the goblet cells, but the mucosa normalized after the acute phase. Hib, by contrast, induced prominent ...
article{fc3e4d3f-eec5-4f6b-8f7e-bed105dc5dde, abstract = {,p,Non-typable Haemophilus influenzae (NTHi) are small, gram-negative bacteria and are strictly human pathogens, causing acute otitis media, sinusitis and community-acquired pneumonia. There is no vaccine available for NTHi, as there is for H. influenzae type b. Recent advances in proteomic techniques are finding novel applications in the field of vaccinology. There are several protein separation techniques available today, each with inherent advantages and disadvantages. We employed a combined proteomics approach, including sequential extraction and analytical two-dimensional polyacrylamide electrophoresis (2D PAGE), and two-dimensional semi-preparative electrophoresis (2D PE), in order to study protein expression in the A4 NTHi strain. Although putative vaccine candidates were identified with both techniques, 11 of 15 proteins identified using the 2D PE approach were not identified by 2D PAGE, demonstrating the complementarily of the ...
TY - JOUR. T1 - Hemophilus influenzae pharyngitis and cellulitis in adults.. AU - Kroneman, O. C.. AU - Brody, H.. PY - 1980/11/1. Y1 - 1980/11/1. N2 - Hemophilus influenzae infections in adults are becoming more common but are often unsuspected in this age group by the primary care physician. Two case reports illustrate pharyngitis, and pharyngitis associated with cellulitis of the neck, in which H influenzae was cultured from the blood. The throat and skin are only two of the many sites for H influenzae infections in adults. As no physical signs are pathognomonic for this organism, its possible role should influence the choice of antibiotics while awaiting culture results. Newer cephalosporins, especially cefamandole and cefoxitin, appear promising in the treatment of these infections.. AB - Hemophilus influenzae infections in adults are becoming more common but are often unsuspected in this age group by the primary care physician. Two case reports illustrate pharyngitis, and pharyngitis ...
Haemophilus influenzae (including Hib) is a bacterium that can cause a severe infection, occurring mostly in infants and children younger than five years of age. It can cause lifelong disability and be deadly. In spite of its name, Haemophilus influenzae bacteria do not cause influenza (the "flu").. There are six identifiable types of Haemophilus influenzae bacteria (a through f) and other non-identifiable types (called nontypeable). The one most people are familiar with is Haemophilus influenzae type b, or Hib. Theres a vaccine that can prevent disease caused by Hib, but not the other types of Haemophilus influenzae bacteria.. ...
Haemophilus influenzae type b HAEMOPHILUS INFLUENZAE TYPE B (HIB) VACCINES FOR AUSTRALIAN CHILDREN: INFORMATION FOR IMMUNISATION PROVIDERS Disease and epidemiology Haemophilus influenzae type b (Hib) is
Example(s): ACT-HIB (Haemophilus influenzae type b (Hib) vaccine),Infanrix Hexa (tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b, and hepatitis B combined vaccine (DTaP-IPV-Hib-hep B, called the 6-in-1)),Pentacel (tetanus, diphtheria, pertussis, polio, and Haemophilus influenzae type b combined vaccine (DTaP-IPV-Hib, called the 5-in-1))
Our investigation of a large collection of invasive NTHi isolates has allowed us to determine if particular LOS biosynthetic genes are present and have altered expression in sterile niches in the human host. While five out of seven of these biosynthetic genes (lic1A, lic3A, lic3B, lex2A, and lgtC) show no significant correlation with an ON or OFF expression state during invasive infection, we demonstrate that lic2A remains OFF in invasive isolates and oafA ON is statistically overrepresented in invasive isolates compared to the level in carriage isolates.. Our observation that lic2A is OFF in most invasive isolates is intriguing, as this finding appears contradictory to earlier results. Expression of lic2A was previously demonstrated to confer resistance to human serum (31), and modification of the NTHi LOS inner core with a galactose by Lic2A has been shown to shield the cells from in vitro neutrophil-mediated killing assays when lic1A is phase-varied OFF, with this modification being ...
TY - JOUR. T1 - Animal Models for the Study of Noninvasive Haemophilus influenzae Disease. T2 - Pulmonary Clearance Systems. AU - Hansen, Eric J.. AU - Toews, Galen B.. PY - 1992/6. Y1 - 1992/6. N2 - Nontypeable Haemophilus influenzae are increasingly being recognized as an important cause of disease in the lower respiratory tract. Information about the pathogenesis of these infections has been limited until recently by the paucity of experimental animal models for studying the host-parasite interaction in vivo. Three different animal models for investigation of the interaction of nontypeable H. influenzae with the lower respiratory tract have been used: Two involve the evaluation of short-term pulmonary clearance in mice or rats, while a new, long-term infection model in rats mimics the more chronic bronchopulmonary infections sometimes caused by these organisms. Results obtained in these three model systems indicate that both humoral and cellular immune mechanisms are involved in immunity to ...
PubMedID: 23291945 | Safety, reactogenicity and immunogenicity of a booster dose of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Malian children. | Human vaccines & immunotherapeutics | 2/1/2013
TY - JOUR. T1 - Regulation of virulence gene expression resulting from streptococcus pneumoniae and nontypeable haemophilus influenzae interactions in chronic disease. AU - Cope, Emily K.. AU - Goldstein-Daruech, Natalia. AU - Kofonow, Jennifer M.. AU - Christensen, Lanette. AU - McDermott, Bridget. AU - Monroy, Fernando. AU - Palmer, James N.. AU - Chiu, Alexander G. AU - Shirtliff, Mark E.. AU - Cohen, Noam A.. AU - Leid, Jeff G.. PY - 2011/12/5. Y1 - 2011/12/5. N2 - Chronic rhinosinusitis (CRS) is a common inflammatory disease of the sinonasal cavity mediated, in part, by polymicrobial communities of bacteria. Recent molecular studies have confirmed the importance of Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) in CRS. Here, we hypothesize that interaction between S. pneumoniae and NTHi mixed-species communities cause a change in bacterial virulence gene expression. We examined CRS as a model human disease to validate these polymicrobial interactions. Clinical ...
The Report Haemophilus influenzae Type B Infections Global Clinical Trials Review, H1, 2016 provides information on pricing, market analysis, shares,...
H. influenzae type b has been nearly abolished in the U.S. due to effective vaccine development, which has been available since 1988. Immunization with the Hib vaccine can help prevent Haemophilus influenzae type b disease. In rare cases, children may still develop H. influenzae type b infections. This can occur if the child has not completed their series of immunizations or in older children who did not receive the vaccine as an infant. ...
H. influenzae type b has been nearly abolished in the U.S. due to effective vaccine development, which has been available since 1988. Immunization with the Hib vaccine can help prevent Haemophilus influenzae type b disease. In rare cases, children may still develop H. influenzae type b infections. This can occur if the child has not completed their series of immunizations or in older children who did not receive the vaccine as an infant.. ...
Collected resources and information for haemophilus influenzae type b (hib) disease and vaccination: Access the latest recommendations, news, information, and resources from IAC, government agencies, professional journals, and other organizations in one spot on immunize.org.
Non-typeable Haemophihis influenzae (NTHi) is a significant cause of otitis media in children. We have employed single and multiple step electrospray ionization mass spectrometry (ESIMS) and NMR spectroscopy to profile and elucidate lipopolysaccharide (LPS) structural types expressed by NTHi strain 162, a strain obtained from an epidemiological study in Finland. ESIMS on O-deacylated LPS (LPS-OH) and core oligosaccharide (OS) samples of LPS provided information on the composition and relative abundance of glycoforms differing in the number of hexoses linked to the conserved inner-core element, L-alpha-D-Hepp-(1--, 2)-[PEtn --, 6]-L-alpha-D-Hepp-(1 --, 3)-L-alpha-D-Hepp-(1 --, 5)(.)[PPEtn --, 4]-alpha-Kdop-(2 --, 6)-Lipid A of H. influenzae LPS. The strain examined was found to elaborate Hex2 to Hex5 LPS glycoform populations having structures identical to those observed for H. influenzae strain Rd [Risberg, A.; Masoud, H.; Martin, A.; Richards, J.C.; Moxon, E.R.; Schweda, E.K.H. Eur. J Biochem. ...
Haemophilus influenzae is gram negative rod. There are 6 serotypes of haemophilus influenzae which include serotypes a, b,c, d, e and f which are based on the polysaccharide capsules.
Haemophilus influenzae (H. influenzae) is a group of bacteria that can cause different types of infections in babies and children. H. influenzae most often cause ear, eye, or sinus infections. They also cause pneumonia.
article{a2ab6767-ca6c-4527-8f1e-217da06cea72, abstract = {Nontypeable Haemophilus influenzae (NTHi) commonly causes local disease in the upper and lower respiratory tract and has recently been shown to interfere with both the classical and alternative pathways of complement activation. The terminal pathway of the complement system is regulated by vitronectin that is a component of both plasma and the extracellular matrix. In this study, we identify protein E (PE; 16 kDa), which is a recently characterized ubiquitous outer membrane protein, as a vitronectin-binding protein of NTHi. A PE-deficient NTHi mutant had a markedly reduced survival in serum compared with the PE-expressing isogenic NTHi wild type. Moreover, the PE-deficient mutant showed a significantly decreased binding to both soluble and immobilized vitronectin. In parallel, PE-expressing Escherichia coli bound soluble vitronectin and adhered to immobilized vitronectin compared with controls. Surface plasmon resonance technology ...
Haemophilus influenzae are fastidious facultatively anaerobic Gram-negative bacteria that cause a range of human infections including otitis media, meningitis, epiglottitis and pneumonia [1, 2]. H. influenzae lacks all enzymes in the biosynthetic pathway for the porphyrin ring and as a result is unable to synthesize protoporphyrin IX (PPIX), the immediate precursor of heme. Since H. influenzae cannot synthesize PPIX the organism has an absolute growth requirement for an exogenous source of PPIX or heme [3, 4]. As a result of this growth requirement H. influenzae has evolved a complex multifunctional array of uptake mechanisms to ensure that it is able to utilize available porphyrin in vivo [5]. One protein shown to be involved in utilization of heme by H. influenzae is the heme binding lipoprotein HbpA [6-8]. HbpA was initially identified as a potential constituent of a heme acquisition pathway following transformation of an H. influenzae genomic DNA library into Escherichia coli and screening ...
This is a retrospective study about serotype distribution and antibiotic resistance of MEF S. pneumoniae and H. influenzae isolates collected from children before introduction of PCV10 and Hib conjugate vaccines nationwide. Microbiological diagnosis of AOM is not done on a routine basis in Bulgaria and this mild disease is underrepresented in our data set. Also, the tympanocentesis is not a common practice in our country. Thus, bacterial cultures studied here most likely represent cases of severe otitus media or patients with a complicated AOM.. The analysis included 128 S. pneumoniae isolates, of which 86% occurring in children aged ≤ 5 years. We found a relatively high rate of serotype 19F infections (20.3%), which is in accordance with the serotype distribution observed in the studies of AOM in German children [8], and the Finland [7]. Serotypes 6B and 19A were next most prominent, each comprising about 16% and 11%, respectively of the overall data set. The coverage calculations for the ...
At its meeting on April 16, 1975, the Committee on Infectious Diseases reconsidered the problem of ampicillin-resistant strains of Hemophilus influenzae type b. The following facts were noted:. (1) Strains of H. influenzae type b highly resistant in vitro to ampicillin have been reported from 20 states and the District of Columbia.1. (2) These strains were isolated from children with sepsis, meningitis, cellulitis, epiglottitis, suppurative arthritis, and pneumonia. Some of the children died when the resistance of the etiologic strain was not appreciated.. (3) The prevalence of these strains is still uncertain but appears to be at a low level in most communities. Epidemiologic studies, however, indicate these strains may infect many children in closed communities, such as day-care centers.2. The Committee believes a modification of its prior statement3 is warranted based on the wide-spread occurrence of these strains:. (1) Initial management of children with documented or suspected severe ...
Introduction to Annual Summary of Communicable Diseases, 2002. List of Reportable Diseases, 2002. Number of Cases of Selected Reportable Diseases, 2002. Fifty-six cases of invasive Haemophilus influenzae disease (1.2 per 100,000 population) were reported in 2001. Case-patients ranged in age from newborn to 89 years, (median, 63 years). Nineteen (34%) had pneumonia, 22 (39%) had bacteremia without another focus of infection, four (7%) had meningitis, and 11 (20%) had other conditions. Twelve (21%) deaths were reported among these cases.. Only one case was known to be type b (Hib), compared to three cases in 2000 and five cases in 1999. The Hib case reported in 2001 occurred in a 5-year-old with a complete vaccine history and no underlying medical conditions. Epiglottitis was the type of infection, and the patient survived. Nineteen (34%) of the Haemophilus influenzae isolates were not available for typing at MDH. Of the total 37 isolates for which typing was performed (including the one [3%] type ...
Haemophilus influenzae (tudi Pfeifferjev bacil) je vrsta hemofilusov[1], gramnegativnih pleomorfnih (polimorfnih) bacilov, to pomeni, da se njihova oblika prilagaja okolju, lahko postanejo bacili, kokobacili ali tudi vibriji. Je fakultativno anaerobna oportunistična bakterija, ki jo je prvi opisal Richard Pfeiffer leta 1892 med pandemijo gripe oziroma influence.[2] Sprva so zmotno predvidevali, da povzroča gripo, in sicer vse do leta 1933, ko so odkrili virus gripe. Haemophilus influenzae, pri 80% populacije, naseljuje nosno-žrelni predel (nasopharynx) in je del normalne mikrobne flore. Haemophilus influenzae (tipa B) povzroča različne lokalizirane in invazivne okužbe,[3] zlasti vnetja dihal, paranazalnih sinusov, srednjega ušesa, veznic, možganskih ovojnic, seroznih mren in sklepov, lahko pa tudi sepso. H. influenzae raste le na krvnem agarju in čokoladnem agarju, na katerega je cepljen tudi Staphylococcus aureus[1], s tem dodamo rastni faktor V (koencim ali NAD+) in X (hematin), pri ...
The Haemophilus influenzae HMW1 adhesin is a high-molecular weight protein that is secreted by the bacterial two-partner secretion pathway and mediates adherence to respiratory epithelium, an essential early step in the pathogenesis of H. influenzae disease. In recent work, we discovered that HMW1 is a glycoprotein and undergoes N-linked glycosylation at multiple asparagine residues with simple hexose units rather than N-acetylated hexose units, revealing an unusual N-glycosidic linkage and suggesting a new glycosyltransferase activity. Glycosylation protects HMW1 against premature degradation during the process of secretion and facilitates HMW1 tethering to the bacterial surface, a prerequisite for HMW1-mediated adherence. In the current study, we establish that the enzyme responsible for glycosylation of HMW1 is a protein called HMW1C, which is encoded by the hmw1 gene cluster and shares homology with a group of bacterial proteins that are generally associated with two-partner secretion ...
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Five tests--satellitism, synthesis of porphyrins, acid production from sucrose, beta-galactosidase activity (ONPG), and indole production--to differentiate between strains of Haemophilus influenzae and strains of V-dependent Haemophilus species were evaluated. Six per cent of strains of H influenzae were misidentified as H parainfluenzae by a test for satellitism using filter paper discs impregnated with X factor, V factor, or both, applied to Columbia Agar. None of seven nutrient agars tested grew Haemophilus species, and determined accurately the X factor requirement. Synthesis of porphyrins from delta-aminolaevulinic acid provided a reliable means of demonstrating that X factor was required. A test for the production of acid from sucrose discriminated successfully between strains of V-dependent Haemophilus species (positive) and H influenzae (negative). Most isolates were identified correctly by the ONPG test, but occasional V-dependent strains were negative and could be misidentified as H ...
Haemophilus influenzae Antibody Does this test have other names? Haemophilus influenzae type b (Hib) IgG antibody level What is this test? This test measures the amount of anti-Hib IgG immunoglobulin, or antibody, in your blood. There are many types of Haemophilus influenza bacteria. They can live in your mouth, throat, ears, and airways and dont always cause illness. H. influenza type b (Hib) one of the most serious types. It doesnt cause the flu, although it has a similar-sounding name. It causes ba...
Viral co-infection does not reduce efficacy of vaccination against nontypeable Haemophilus influenzae middle ear infection in a rat ...
Vaccination against influenza and Streptococcus pneumoniae is recommended for elderly and immunocompromised individuals. However, there is little information concerning the efficacy of vaccination in specific groups of patients. In this study, 52 patients underwent vaccination against influenza, S. pneumoniae and Haemophilus influenzae type b (Hib) as they attended hospital outpatient clinics. Serum was analysed prior to vaccination and 4-6 weeks afterwards. Antibody titres against S. pneumoniae and Hib were compared with reference values corresponding to the geometric mean titres of a healthy UK population. For influenza vaccination, haemagglutination inhibition (HI) titres were measured against three inactivated strains; a titre of , or = 1/40 was considered protective. No patient had protective titres to all three antigens prior to vaccination and 41 patients (85%) had titres , 1/40 to all 3 strains. Post vaccination only 9/48 patients (19%) achieved protective antibody titres. Resistance to ...
This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB® in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 µg/mL, C 1.68 µg/mL; post-vaccination: MN 18.53 µg/mL and C 17.55 µg/mL; in CB from MN 14.46 µg/mL and from C 17.04 µg/mL. Infants from MN and C mothers presented respectively at two months: 5.18 µg/mL and 8.60 µg/mL and at six months: MN 3.42 µg/mL and C 2.18 µg/mL. Antibody ...
Haemophilus influenzae type b (or Hib) is a vaccine-preventable disease that can cause ear infections, pneumonia, and bacterial meningitis, especially in young children. Learn more.
Developing a vaccine for Haemophilus influenzae serotype a: Proceedings of a workshop - CCDR: Volume 43-5, May 4, 2017: Implementation science
Haemophilus influenzae type b is a serious bacterial disease that usually strikes children younger than 5. It is spread from person-to-person by coughing and sneezing.
TY - JOUR. T1 - Characterization and sequence analysis of the lsg (LOS synthesis genes) locus from Haemophilus influenzae type b. AU - McLaughlin, R.. AU - Lee, N. G.. AU - Abu Kwaik, Y.. AU - Spinola, Stanley. AU - Apicella, M. A.. PY - 1994. Y1 - 1994. UR - http://www.scopus.com/inward/record.url?scp=0027947863&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027947863&partnerID=8YFLogxK. M3 - Article. VL - 1. SP - 165. EP - 174. JO - Innate Immunity. JF - Innate Immunity. SN - 1753-4259. IS - 3. ER - ...
TY - JOUR. T1 - Transcription of genes encoding iron and heme acquisition proteins of Haemophilus influenzae during acute otitis media. AU - Whitby, Paul W.. AU - Sim, Kim Eng. AU - Morton, Daniel J.. AU - Patel, Janak A.. AU - Stull, Terrenck L.. PY - 1997/11/7. Y1 - 1997/11/7. N2 - Unencapsulated Haemophilus influenzae is the second most common etiologic agent of otitis media in children. H. influenzae requires heme for aerobic growth in vitro and is able to utilize hemoglobin and complexes of heme-hemopexin, heme-albumin, and hemoglobin-haptoglobin and ferritransferrin as sources of iron and heme in vitro. Several of the acquisition mechanisms have been characterized and been shown to be heme repressible in vitro. However, little is known about the expression of heme and/or iron acquisition mechanisms during infections in the middle ear. This study was performed to determine if the genes encoding heme and iron acquisition proteins are transcribed during in vivo growth and to compare these ...
The Virus and Its Effect Haemophilus influenzae (including Hib) is a bacterium that can cause a severe infection, occurring mostly in infants and children younger than five years of age. In spite of its name, Haemophilus influenzae does not cause influenza (the flu). There are six identifiable types of Haemophilus influenzae bacteria (a through f)…
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Characterization of intact lipopolysaccharides from the Haemophilus influenzae strain RM 118 using electrophoresis-assisted open-tubular liquid chromatography-mass spectrometry
Several properties of Haemophilus influenzae outer membrane proteins were analyzed to define related proteins in various isolates. H. influenzae type b 760705 had six major outer membrane proteins with the following characteristics. Protein a (Mr, 47,000) demonstrated heat modifiability in sodium dodecyl sulfate; its apparent molecular weight was 34,000 at temperatures below 60 degrees C. This protein was extracted from cell envelopes by using Triton X-100-10 mM MgCl2; in cell envelope preparations, the protein was degraded by trypsin. Proteins b (Mr, 41,000) and c (Mr, 40,000) were insensitive to trypsin degradation, were not heat modifiable in sodium dodecyl sulfate, and were peptidoglycan associated in 0.5% Triton X-100-0.2% sodium dodecyl sulfate. The amount of protein b was reduced in ultrasonically obtained cell envelopes. Protein d (Mr, 37,000) was heat modifiable in sodium dodecyl sulfate with an Mr of 28,000 at temperatures below 100 degrees C and was degraded by trypsin, leaving a ...
Haemophilus influenzae. Coloured Scanning Electron Micrograph (SEM) of a cluster of Haemophilus influenzae bacteria. These non-motile, Gram- negative bacilli bacteria are an important pathogen in young children. They colonize the upper respiratory tract in most humans within the first few months of life, and usually are harmless. However, they may spread locally and cause diseases of the lower respiratory tract, such as bronchitis and pneumonia. Certain capsulated strains are the most common cause of bacterial meningitis and epiglottitis in children. Treatment includes the use of antibiotic drugs. Magnification: x2500 at 6x6cm size. - Stock Image B220/0841
Haemophilus influenzae rec-2 protein: homologous to comE-ORF3 gene product; involved in passing DNA through competent-cell envelope; isolated from Haemophilus influenzae; amino acid sequence in first source; GenBank L20805
Streptococcus pneumoniae and H. influenzae are fastidious bacteria. Care must be taken during transport of specimen. Specimens must be transported promptly to the laboratory preferably within 1-2 hours.. Blood can only be transported after collecting in a culture broth containing appropriate anticoagulant. The inoculated medium can be held at room temperature (20°C- 25 °C) for 4 - 6 hours before incubation at 37 °C. The samples during transportation should be protected from extremes of temperature (less than 18 °C, more than 30 °C) and direct sunlight.. SOP for processing clinical specimens for laboratory diagnosis of Streptococcus pneumoniae and Haemophilus influenzae will be continued in the following posts: ...
WHO/V&B/AVI Choosing the Right Vaccine WHOs Expanded Programme on Immunization (EPI) -Launched by WHO in 1974 -Initially 6 target diseases (TB, Diphtheria, Pertussis, Tetanus, Measles, Polio) -Hepatitis B added in 1991 -Hib added in 1998 (for those countries with moderate to high burden of Hib disease)
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Haemophilus influenzae is a common commensal organism of the human respiratory tract that initiates infection by colonizing the nasopharyngeal epithelium. In some individuals, colonization is followed by localized respiratory tract or systemic disease. To gain insight into the mechanisms by which H. influenzae attaches to and persists within the nasopharynx, we examined the interactions between a nonpiliated clinical isolate of H. influenzae and human epithelial cells. We noted substantial adherence that occurred independently of pili and required viable bacteria capable of de novo protein synthesis. Comparison of profiles of outer membrane proteins synthesized during incubation with epithelial cells for adherent and nonadherent bacteria identified several candidate adhesin molecules. In addition, a small number of adherent bacteria were capable of entering epithelial cells in a process that was inhibited by cytochalasin D and colchicine. The suggestion from our studies is that one or more of ...
The introduction of routine infant immunization with Haemophilus influenzae type b (Hib) conjugate vaccines in the United Kingdom in 1992 led to a significant reduction in invasive disease due to this organism. Subsequently, between 1999 and 2003 there was an increase in the number of immunized children with Hib infection. We investigated whether the rise in cases was related to changes in anti-polyribosylribitol phosphate (PRP) antibody concentration or avidity. Using stored sera, we analyzed temporal changes in antibody levels among 3- to 5-year-old children immunized between 1991 and 2000. Anti-PRP antibody concentrations were higher in 3- to 5-year-olds who received infant immunization in 1991 than those in subsequent years. This difference may be related to changes in either the mode of administration of Hib conjugate vaccines or the rates of Hib nasopharyngeal carriage. This study emphasizes the factors affecting anti-PRP antibody concentration following immunization with conjugate vaccines and
We analyzed national Haemophilus influenzae (Hi) surveillance data from 1994 and 1995 to describe the epidemiology of Hi invasive disease among persons of all ages. Serotype data were available for 376 (56%) of 669 reported Hi cases among children aged 4 years or younger; 184 (49%) were H. influenzae type b (Hib). Among children aged 4 or younger, incidence (per 100,000) of all Hi invasive disease was 1.8 in 1994 and 1.6 (p < 0.05) in 1995. Children aged 5 months or younger had the highest average annual incidence rate of Hib invasive disease (2.2 per 100,000); children aged 6 to 11 months had the next highest rate (1.2 per 100,000) (p < 0.05). Of 181 children with Hib invasive disease whose age in months was known, 85 (47%) were too young (aged 5 months or younger) to have completed a primary series with an Hib-containing vaccine. Of the 83 children with known vaccination status who were eligible to receive a primary series (aged 6 months or older), 52 (63%) were undervaccinated, and the
Haemophilus influenzae efficiently colonizes and persists at the human nasopharyngeal mucosa, causing disease when it spreads to other sites. Nitric oxide (NO) represents a major antimicrobial defense deployed by host cells in locations colonized by H. influenzae during pathogenesis that are likely to vary in oxygen levels. Formate-dependent nitrite reductase regulator (FNR) is an oxygen-sensitive regulator in several bacterial pathogens. We report that fnr of H. influenzae is required for anaerobic defense against exposure to NO donors and to resist NO-dependent effects of gamma interferon (IFN-gamma)-activated murine bone marrow-derived macrophages. To understand the mechanism of resistance, we investigated the role of FNR-regulated genes in defense against NO sources. Expression analysis revealed FNR-dependent activation of nrfA, dmsA, napA, and ytfE. Nonpolar deletion mutants of nrfA and ytfE exhibited sensitivity to NO donors, and the ytfE gene was more critical for survival. Compared to the wild
The study aims at optimization of the ideal conditions of pH and rpm with different time intervals for better growth of Haemophilus influenzae. Broth cultures were grown for a period of 24 hours with different pH and rpm. The OD was recorded every six hours to study the growth pattern and growth conditions.The peak OD was recorded with culture at pH of 7.2 and rpm of 200. There have been various reports of invasive infections caused by non type b serotypes and the advent of non-typeable strains and failure of hib vaccinations in such conditions. In this context culturing and rapid diagnosis of strains become vital. Though the nutritional requirements of Haemophilus species are similar there has been no data on the growth patterns. The maximum OD recorded was 0.78 at 24 hours after inoculation.. ...
If there ever has been a vaccine that, at least on the surface, looks like a hands-down success story, it would have to be the Hib vaccine, against haemophilus influenzae type b, a bacterial infection (in spite of its name), which can be serious and occurs primarily among children under 5 (although breastfeeding is an effective preventative). The best known serious complication of this disease is meningitis, but other very major complications, including epiglottitis, pneumonia, and cellulitis also can result.. The vaccine, it would seem, has resulted in considerable reduction in disease incidence (,99% compared to the prevaccine era).. It is worth noting, however, that we really dont know all that much about the incidence of haemophilus influenzae b, particularly prior to vaccine licensure. According to the CDC, haemophilus influenzae infections became nationally reportable in 1991, although several areas carried out active surveillance...which allowed estimates of disease nationwide. And ...
Our open randomised study was approved by the relevant local ethics committees. Infants aged 8-12 weeks who were eligible for routine primary immunisation with diphtheria, tetanus, pertussis, and oral poliomyelitis vaccines in Gloucester and North Hertfordshire health districts were recruited in general practices, and parents written informed consent was obtained. Infants were randomly allocated to receive one of six different sequences of a single batch of a Haemophilus influenzae type b polysaccharide (polyribosylphosphate)-tetanus conjugate (ActHIB, Pasteur-Merieux-MSD, Lyons, France) or a single batch of a Haemophilus influenzae type b oligosaccharide-mutant diphtheria toxin conjugate (HibTITER, Cyanamid-Lederle-Praxis Biologicals, Pearl River, USA), or both. The vaccines were administered as a single injection mixed with adsorbed diphtheria, tetanus, and pertussis vaccine at 2, 3, and 4 months of age.. After each injection of vaccine, parents recorded local reactions, temperature, and ...
Abstract Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr cor - relates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure con - trol levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative ...
My research focuses on Streptococcus pneumoniae and non-typeable Haemophilus influenzae. The bacteria that I study asymptomatically colonize the respiratory tract of 10-50% of healthy individuals. While asymptomatic colonization is far more common than disease, S. pneumoniae and H. influenzae are important causes of bacterial infections in children and adults (e.g., otitis media, pneumonia, and exacerbations of chronic obstructive pulmonary disease (COPD)). Moreover, these infections are frequently, and controversially, treated with antibiotics. We use state-of-the-art methods that integrate clinical epidemiologic, and laboratory studies to elucidate factors that tip the balance between asymptomatic bacterial colonization and disease. Additional projects focus on how disruptions of homeostasis in the respiratory and gastrointestinal microbiota influence colonization resistance, development of antibiotic resistance, and risk of hospital-acquired infections. We use data and specimens from clinical ...
This article discusses the epidemiology of invasive Haemophilus influenzae type b (Hib) disease and its prevention by vaccination for the period 1995 to 2005, comparing surveillance data for 1995-2000, when both PRP-OMP and HbOC vaccines were used, with 2000-2005, when only PRP-OMP vaccine was used.
van Alphen, Loek, Caugant, Dominique A, Duim, Birgitta, ORourke, Maria and Bowler, Lucas (1997) Differences in genetic diversity of noncapsulated Haemophilus influenzae from various diseases. Microbiology, 143 (4). pp. 1423-1431. Full text not available from this repository ...
Dried blood spots (DBS) have been proposed as potentially tool for detecting invasive bacterial diseases. We evaluated the use of DBS for S. pneumoniae and H. influenzae detection among children in Mozambique. Blood for DBS and nasopharyngeal (NP) swabs were collected from children with pneumonia and healthy aged | 5 years. Bacterial detection and serotyping were performed by quantitative PCR (qPCR) (NP and DBS; lytA gene for pneumococcus and hpd for H. influenzae) and culture (NP). Combined detection rates were compared between children with pneumonia and healthy. Of 325 children enrolled, 205 had pneumonia and 120 were healthy. Pneumococci were detected in DBS from 20.5 and 64.2% of children with pneumonia and healthy, respectively; NP specimens were positive for pneumococcus in 80.0 and 80.8%, respectively. H. influenzae was detected in DBS from 22.9% of children with pneumonia and 59.2% of healthy; 81.4 and 81.5% of NP specimens were positive for H. influenzae, respectively. DBS detected
Haemophilus influenzae ATCC ® 10211™ Designation: AMC 36-A-1 TypeStrain=False Application: Media testing Quality control Quality control strain Susceptibility disc testing Susceptibility testing Respiratory research
Haemophilus influenzae ATCC ® 10211™ Designation: AMC 36-A-1 TypeStrain=False Application: Media testing Quality control Quality control strain Susceptibility disc testing Susceptibility testing Respiratory research
Coloured scanning electron micrograph (SEM) of Haemophilus influenzae, coccobacillus prokaryote (dividing); causes meningitis in children, pneumonia, epiglottitis, laryngitis, conjunctivitis, neonatal infection, otitis media (middle ear infection) and sinusitis in adults. This bacterium was mistakenly considered to be the cause of influenza until 1933 when scientists determined that influenza was virus related. Magnification: x16,000 when shortest axis printed at 25 millimetres. - Stock Image C032/2689
Haemophilus influenzae is a Gram-negative bacillus that is an exclusively human pathogen. There are six capsular serotypes (a-f), of which type b (Hib) is a major cause of childhood infectious disease. Transmission occurs by close bodily contact, the main source being other children, and is usually followed by nasopharyngeal carriage, following which susceptible people may develop disease....
Pre o de Broncho-vaxom, laborat rio Takeda, droga: Lisado bacteriano + Diplococcus pneumoniae + Haemophilus influenzae + Klebsiella ozanae + Klebsiella pneumoniae + Neisseria catarrhalis + Staphylococcus aureus + Streptococcus. Encontre pre os atualizados de todos os medicamentos / rem dios / princ pios ativos comerciais e gen ricos.
List of Drugs with Haemophilus Influenzae conjugate Vaccine (Meningococcal Protein conjugate)- generic salt/ molecule/chemical/health-medicine ...
A collection of 2,209 isolates of six polysaccharide capsule types of Haemophilus influenzae, including 1,975 serotype b isolates recovered in 30 countries was characterized for electrophoretically demonstrable allele profiles at 17 metabolic enzyme loci. Two hundred eighty distinct multilocus genot …
Sialic acid in the lipolysaccharide of Haemophilus influenzae: Strain distribution, influence on serum resistance and structural characterization: Mol.Microbiol.
BioAssay record AID 83643 submitted by ChEMBL: The compound was tested for antibacterial activity against resistant Haemophilus influenzae 76..
P2.3 Haemophilus influenzae immunisation A Cochrane Review/meta-analysis of six placebo-controlled RCTs evaluating 557 patients, conducted to test the efficacy
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the ...
Characterization of novel structure features in the lipopolysaccharide of non-disease assciated nontypeable Haemophilus influenzae .
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Liu, L., Chu, L., Liu, Q., Wang, C., Xia, Y. and Peng, Y. (2010) A Comparative Study on Biofilm Formation of Non-typeable Haemophilus influenzae and Pseudomonas aeruginosa under Single Culture or Co-Culture. African Journal of Microbiology Research, 4, 180-184.
Abdelhameed, Ali Saber and Morris, Gordon A. and Almutairi, Fahad and Adams, Gary G. and Duvivier, Pierre and Conrath, Karel and Harding, Stephen E. (2016) Solution conformation and flexibility of capsular polysaccharides from Neisseria meningitidis and glycoconjugates with the tetanus toxoid protein. Scientific Reports, 6 (1). 35588/1-35588/11. ISSN 2045-2322 Abdelhameed, Ali Saber and Adams, Gary G. and Morris, Gordon A. and Almutairi, Fahad M. and Duvivier, Pierre and Conrath, Karel and Harding, Stephen E. (2016) A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate. Scientific Reports, 6 (1). 22208/1-22208/11. ISSN 2045-2322 Morris, Gordon A. and Adams, Gary G. and Harding, Stephen E. (2014) On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review. Food Hydrocolloids, 42 . pp. 318-334. ISSN 0268-005X ...
Haemophilus influenzae strain Rd became the first free-living organism to have its genome sequenced (Fleischmann et al., 1995). The floodgates have opened with over 100 prokaryotic genomes completely or partially sequenced. However, the acquisition and analysis of sequence data is not an end in itself; instead it is a starting point for generating hypotheses that can be tested in the laboratory. It is clear that knowledge of the complete genome sequence of an organism does not tell us a great deal about the composition or functional capabilities of the organism. Homology, or sequence similarity, provides clues, but it does not prove gene function. Furthermore, a large percentage of genes have no matches to known genes. For example, at the time of sequence release, up to 62% of predicted protein-coding genes in the Methanococcus jannaschii genome had no matches with genes from other organisms (Bult et al., 1996). Elucidating the function of these "ORFan" or "FUN" ... ...
Study from Oxford, UK showed that there was significantly low level of carriage in vaccinated infants compared to controls. The carrier rate was 1.5% in vaccinated as compared to 6.3% in unvaccinated infants. Amongst children with family history of exposure to Hib the carrier rate was 8.7 % in vaccinated & 38.5& in unvaccinated group. Only 3.7% vaccinated siblings were carrier of an index carrier as compared to 12.0% in unvaccinated group. There was no difference in the period for which a child remained carrier as it was 5.2 weeks in vaccinated Vs 5.6 weeks in unvaccinated group (9). Similar study from Finland has shown that 3.5% of unvaccinated children were carrier as compared to 0% of vaccinated children (2). In Iceland it was shown that carrier rate dropped from 16% to 0.5 % in 2years after mass vaccine ...
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Erwin, A.L., Sandstedt, S.A., Bonthius, P.J., Geelhood, J.L., Nelson, K.L., Unrath, W.C.T., Diggle, M.A., Theodore, M.J., Pleatman, C.R., Mothershed, E.A., Sacchi, C.T., Mayer, L.W., Gilsdorf, J.R., Smith, A.L.. (2008). Evidence for clonality of non-typeable Haemophilus influenzae. Journal of Bacteriology 1473-83 ...
Antibody Responses, Children, Complement, Conjugate Vaccines, Diphtheria, Haemophilus, Haemophilus Influenzae, Haemophilus Influenzae Type B, Human, Immunization, Infant, Infants, Pertussis, Schedules, Serum, Tetanus, Vaccines
Affect, Diphtheria, Diphtheria-pertussis-tetanus Vaccine, Disease, Diseases, Haemophilus, Haemophilus Influenzae, Haemophilus Influenzae Type B, Health, Hepatitis, Hepatitis B, Immunization, Incidence, Law, Laws, Measles, Methods, Mumps, Pertussis, Public Health
Convincing studies demonstrate significant protection during breastfeeding against diarrhoea, respiratory tract infections, otitis media, bacteraemia, bacterial meningitis, botulism, urinary tract infections and necrotizing enterocolitis. There is also good evidence for enhanced protection for years after the termination of breastfeeding against Haemophilus influenzae type b infections, otitis media, diarrhoea, respiratory tract infections and wheezing bronchitis. In some reports breastfeeding has also improved vaccine responses. Several studies show that milk may actively stimulate the immune system of the offspring via transfer of anti-idiotypic antibodies and lymphocytes. This may explain why breastfeeding diminishes the risk of developing coeliac disease. Some investigations suggest that there may also be a similar effect on allergic diseases and autoimmune diseases, as well as inflammatory bowel diseases and certain tumours. This needs to be confirmed.. ...
a Other bacterial strains tested wereNeisseria lactamica (n = 5), N. gonorrhoeae(n = 4), N. sicca (n = 1), N. flavescens (n = 1), N. cinerea (n = 1),N. elongata (n = 1), N. pharyngis(n = 1), N. polysaccharidae (n = 1),Enterococcus faecalis (n = 5), Lancefield group B streptococci (n = 5), coagulase-negative staphylococci (n = 5), methicillin-resistant S. aureus(n = 5), E. coli (n = 5), E. coli K1 (n = 1), P. aeruginosa (n = 5), diphtheroids (n = 5), Proteus mirabilis(n = 5), Acinetobacter sp. (n = 5),K. pneumoniae (n = 5), Moraxella catarrhalis(n = 5), E. cloacae (n = 5), andH. influenzae types a (n = 1), d (n = 1), e (n = 1), and f (n = 1). Viruses tested were herpes simplex virus types 1 and 2 (n = 4), varicella-zoster virus (n = 1), cytomegalovirus (n = 2), and hepatitis B virus (n = 2). ...
Haemophilus influenzae is a Gram-negative human-restricted bacterium that can act as a commensal and a pathogen of the respiratory tract. Especially nontypeable H. influenzae (NTHi) is a major threat to public health and is responsible for several infectious diseases in humans, such as pneumonia, sinusitis, and otitis media. Additionally, NTHi strains are highly associated with exacerbations in patients suffering from chronic obstructive pulmonary disease. Currently, there is no licensed vaccine against NTHi commercially available. Thus, this study investigated the utilization of outer membrane vesicles (OMVs) as a potential vaccine candidate against NTHi infections. We analyzed the immunogenic and protective properties of OMVs derived from various NTHi strains by means of nasopharyngeal immunization and colonization studies with BALB/c mice. The results presented herein demonstrate that an intranasal immunization with NTHi OMVs results in a robust and complex humoral and mucosal immune ...
Haemophilus influenzae is a Gram-negative human-restricted bacterium that can act as a commensal and a pathogen of the respiratory tract. Especially nontypeable H. influenzae (NTHi) is a major threat to public health and is responsible for several infectious diseases in humans, such as pneumonia, sinusitis, and otitis media. Additionally, NTHi strains are highly associated with exacerbations in patients suffering from chronic obstructive pulmonary disease. Currently, there is no licensed vaccine against NTHi commercially available. Thus, this study investigated the utilization of outer membrane vesicles (OMVs) as a potential vaccine candidate against NTHi infections. We analyzed the immunogenic and protective properties of OMVs derived from various NTHi strains by means of nasopharyngeal immunization and colonization studies with BALB/c mice. The results presented herein demonstrate that an intranasal immunization with NTHi OMVs results in a robust and complex humoral and mucosal immune ...
Diagnosis Code B96.3 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Free, official coding info for 2018 ICD-10-CM A41.3 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Clark TA, Boitano M, Power PM, Jen FE-C, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP. "A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in nontypeable Haemophilus influenzae." Nat Commun. (January 0.): -.. Ompremcak LB, Rheins MS.. "Scanning electron microscopy of mouse ciliated oviduct and tracheal epithelium infected in vitro with Bordetella pertussis." Can J Microbiol. Vol. 29, (January 1982.): 415-420.. Bakaletz LO, Rheins MS.. "A whole-organ perfusion model of Bordetella pertussis adherence to mouse tracheal epithelium." In Vitro Cell Dev Biol. Vol. 21, no. 6. (January 1985.): 314-320.. Bakaletz LO, DeMaria TF, Lim DJ.. "Effect of preopsonization on phagocytosis of Haemophilus influenzae." Arch Otolaryngol. Vol. 113, no. 5. (January 1987.): 526-529.. Lim DJ, DeMaria TF, Bakaletz LO.. "Functional morphology of the tubotympanum related to otitis media: a review." Am J Otol. ...
These Field Guides will help health workers in their efforts to control, eliminate, or eradicate diseases such as poliomyelitis, neonatal tetanus, yellow fever, diphtheria, pertussis, tetanus, Haemophilus influenzae type b infections, hepatitis B, measles, and rubella. The Field Guides also include standardized methods and procedures for conducting epidemiological surveillance and maintaining an up-to-date information system that makes it possible to take timely and effective decisions. These...
Authors reply to: Interlatoratory reproducility of an enzyme-linked immunosorbent assay for quantitation of antibodies for Haemophilus influenzae type b polysaccharide [Letter to the editor by Madore DV, Quataert SA ...
Haemophilus influenzae type b (Hib) conjugate vaccines represent a new technology wherein an immunogen is targeted to a specific immune response mechanism. Covalent attachment of the Hib polysaccharid
Respiratory syncytial virus was the commonest viral cause of LRTIs and Streptococcus pneumoniae (pneumococcus) and Haemophilus influenzae were the commonest bacterial causes. A significant fraction (one-third in one hospital) of all H. influenzae infections were nontypeable.. Not all of the insights of the BOSTID research group could be summarized in a single paper or even a supplement. The programme provided an intellectual forum in which many lines of enquiry were distilled.2 The complete lack of understanding of how or why children die from pneumonia was identified as a critical future research question. The pathogenesis of ARI, including the complex synergism between viral and bacterial pathogens, was a second significant area. The investigators believed that understanding the mechanisms that controlled the magnitude and selectivity of the human inflammatory response would offer practical opportunities to influence disease outcome. This insight would need to be augmented by knowledge of the ...
Immune Responses against Outer Membrane Protein P6 of Nontypeable Haemophilus influenzae. 耳鼻咽喉科免疫アレルギー. 16:172-173. 1998 ...
Microbiological and molecular epidemiological studies were conducted on 36 multi-resistant Haemophilus influenzae strains, isolated from paediatric patients, over a 26 month period (April 1986 to May 1988). The majority ...
Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alternating with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), menaquinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Menaquinone is an obligatory component of the electron-transfer pathway in bacteria ...
Das Konsiliarlabor für Haemophilus influenzae (KLHi) ist vom Robert Koch-Institut mit der Laborüberwachung invasiver H. influenzae Erkrankungen beauftragt. Zu seinen Aufgaben gehören die Serotypisierung klinischer Isolate und die Beobachtung der antibiotischen Resistenzentwicklung. Im Jahr 2010 wurden Proben von 162 Patienten analysiert. Bei 143 Patienten wurde H. influenzae aus primär sterilen Materialien isoliert (dies entspricht der Anzahl invasiver Erkrankungen). Die überwiegende Mehrheit der Fälle bestand aus nicht-typisierbaren H. influenzae (NTHi, 101 Fälle, 70,6 %), gefolgt von Hif als häufigster Kapselserotyp (30 Fälle; 21,0 %). Erkrankungsfälle mit Hib zeigten sich am dritthäufigsten (11 Fälle; 7,7 %), und ein Hie Fall (0,7%) wurde registriert. Andere Serotypen wurden nicht nachgewiesen. Wie auch schon in den vorigen Jahren (z.B. 2008, vgl. Robert Koch Institut, Epidemiologisches Bulletin 35/2009) war die am meisten von invasiven H. influenzae Infektionen betroffene ...
Sigma-Aldrich offers abstracts and full-text articles by [Sarah E Clark, Julian Snow, Jianjun Li, Tracey A Zola, Jeffrey N Weiser].
Thomas Eagan is a principal consultant specializing in financial analytics solutions for PwC Consulting. Eagan may be reached at [email protected]
Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.
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Honours project: Participate in important research into the stress response in pathogenic bacteria, in particular, Haemophilus influenzae which can lead to several serious diseases in humans.. [Read more about Stress response in pathogenic bacteria: Haemophilus influenzae] ...
1J85: Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): A cofactor bound at a site formed by a knot