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Background. In Orebro County a 2.5-fold increase in the incidence of Haemophilus influenzae HI meningitis was found between 1970 and 1980, an observation that initiated the present study. Materials and methods. In order to search for associations between morbidity in invasive HI infection and possible risk factors, a case-control study was...
Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rate within 7 days of diagnosis was higher for Hie, even after adjustment for age and comorbidities. Multilocus sequence typing revealed a single major circulating clone for both Hif (sequence type 124; 89/99 isolates, 90%) and Hie (sequence type 18; 21/33, 64%), but no association between type and clinical disease or outcome was found.
These are the mainstays of treatment. Initially, invasive and serious H influenzae type b (Hib) infections are best treated with an intravenous third-generation cephalosporin until antibiotic sensitiv... more
In infants and children with suspected bacterial meningitis, CT scanning is recommended before lumbar puncture in patients with the following:{ref1-INVALID REFERENCE} Immunocompromise History of sel... more
The RCPA is the leading organisation representing Pathologists and Senior Scientists in Australasia.. Its mission is to train and support pathologists and senior scientists and to improve the use of pathology testing to achieve better healthcare.. ...
Description: Haemophilus influenzae type b disease, also called Hib disease, is an illness that can cause a potentially fatal brain infection in young children. Hib disease is caused by the bacteria, Haemophilus influenzae serotype b. The Hib bacterium is widespread in humans. Along with other bacteria, it usually lives in the throat and nose without causing illness. In some cases, though, the bacterium breaks through the bodys defenses and causes disease. Hib disease is spread through contact with discharges or droplets from the nose or throat of an infected person and can spread from person to person through sneezing, coughing, or speaking closely with an infected person. A person does not have to have symptoms to spread the bacterium. The most common and severe manifestation of Hib disease is meningitis (inflammation and swelling in the coverings of the brain and spinal cord). Symptoms of meningitis include fever, weakness, vomiting, and a stiff neck. Hib can also cause infection of the ...
Professor Booy trained in paediatrics during the 1980s at the Royal Childrens Hospital, Brisbane, and spent much of the 1990s doing epidemiological research on life threatening infectious diseases in the United Kingdom. This included 4 years in Oxford where he completed a doctorate on the epidemiology and prevention of Haemophilus influenzae type b disease.. In 1999 Professor Booy appointed Professor of Child Health, Head of Department, Royal London Hospital, Queen Mary and Westfield College, University of London. He returned to Australia in early 2005.. Professor Booy has conducted extensive research into serious infections and their prevention with over 150 scientific publications to his credit.. He is on the Scientific Influenza Advisory Group (SIAG) for the Office of Health Protection, Department of Health and Ageing (DoHA) and the Chief Medical Officers Vaccine Advisory Group (VAG) for the Office of Health Protection, DoHA. He is also a member of the Paediatric Scientific Program ...
The authors describe the epidemiology of invasive Hib and nontype b H. influenzae infections in children <15 years of age in the United Kingdom from 1994 until 2008, and show that the resurgence in Hib disease during the years 1999-2003 did not affect the epidemiology of invasive nontype b H. influenzae disease in children, which provides further support against serotype replacement.. ...
The authors describe the epidemiology of invasive Hib and nontype b H. influenzae infections in children <15 years of age in the United Kingdom from 1994 until 2008, and show that the resurgence in Hib disease during the years 1999-2003 did not affect the epidemiology of invasive nontype b H. influenzae disease in children, which provides further support against serotype replacement.. ...
A higher proportion of cases was reported to have occurred within the first two months after vaccination, with 10 cases occurring within 72 hours of vaccination. Vaccination did not alter the expected frequencies of the different clinical entities associated with invasive H. influenzae disease. No estimates of clinical efficacy are possible based on the adverse events submitted to the Food and Drug Administration.". ...
A review of the data from a trial sponsored by the Centers for Disease Control to evaluate the effectiveness of rifampin for the prevention of secondary cases of invasive Haemophilus influenzae type b disease and the recognition of failure of rifampin prophylaxis in some day care centers and families prompted the changed recommendations listed below. An increased risk of invasive H influenzae type b disease in household contacts, particularly in those less than 49 months of age had been demonstrated. Although nursery school and day care center contacts may also be at increased risk of secondary disease, the magnitude of this is uncertain at this time. Preliminary data from ongoing studies suggest that the risk of secondary disease among nursery school contacts may vary widely between centers. Asymptomatic colonization with H influenzae type b is frequent in household contacts of all ages. Rifampin, 20 mg/kg (600 mg maximum dose) given once daily for four days, eradicates H influenzae type b in ...
Non-typeable Haemophilus influenzae (NTHi) and encapsulated Haemophilus influenzae type b (Hib) were inoculated into the middle ears of Sprague-Dawley rats. Tympanic membrane (TM) status was assessed otomicroscopically and specimens from various middle ear areas were prepared for light microscopy at various times during the acute phase and up to 6 months after inoculation. Irrespective of bacteria strain, acute otitis media (AOM) was present in all ears 4 days after inoculation. The Hib-infected ears showed initially a severe course of AOM, but all were otomicroscopically resolved by day 12, at which time a few NTHi-inoculated ears still exhibited middle ear effusion. The TMs infected with Hib had normalized without scar formation, whereas NTHi induced a persistent thickening of the TMs in half of all cases. The middle ear mucosa of NTHi-infected ears initially showed vigorous activity among the goblet cells, but the mucosa normalized after the acute phase. Hib, by contrast, induced prominent ...
PubMedID: 23291945 | Safety, reactogenicity and immunogenicity of a booster dose of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Malian children. | Human vaccines & immunotherapeutics | 2/1/2013
The Report Haemophilus influenzae Type B Infections Global Clinical Trials Review, H1, 2016 provides information on pricing, market analysis, shares,...
In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and situations. The model classifies population members by age, colonization/disease status, and antibody levels, with movement across categories defined by differential equations. We implemented the model for the United States as a whole, England and Wales, and the Alaska Native population. This model accurately simulated Hib incidence in all 3 populations, including the increased incidence in England/Wales beginning in 1999 and the change in Hib incidence in Alaska Natives after switching Hib vaccines in 1996. The model suggests that a vaccine shortage requiring deferral of the booster dose could last 3 years in the United States before loss of herd immunity would result in increasing rates of invasive Hib disease in children <5 years of age.
Haemophilus influenzae is gram negative rod. There are 6 serotypes of haemophilus influenzae which include serotypes a, b,c, d, e and f which are based on the polysaccharide capsules.
Haemophilus influenzae (H. influenzae) is a group of bacteria that can cause different types of infections in babies and children. H. influenzae most often cause ear, eye, or sinus infections. They also cause pneumonia.
TY - JOUR. T1 - Animal Models for the Study of Noninvasive Haemophilus influenzae Disease. T2 - Pulmonary Clearance Systems. AU - Hansen, Eric J.. AU - Toews, Galen B.. PY - 1992/6. Y1 - 1992/6. N2 - Nontypeable Haemophilus influenzae are increasingly being recognized as an important cause of disease in the lower respiratory tract. Information about the pathogenesis of these infections has been limited until recently by the paucity of experimental animal models for studying the host-parasite interaction in vivo. Three different animal models for investigation of the interaction of nontypeable H. influenzae with the lower respiratory tract have been used: Two involve the evaluation of short-term pulmonary clearance in mice or rats, while a new, long-term infection model in rats mimics the more chronic bronchopulmonary infections sometimes caused by these organisms. Results obtained in these three model systems indicate that both humoral and cellular immune mechanisms are involved in immunity to ...
This page describes the Haemophilus influenzae type B bacteria which causes severe infections in young children, including treatment and preventative approaches(vaccination)
This is a retrospective study about serotype distribution and antibiotic resistance of MEF S. pneumoniae and H. influenzae isolates collected from children before introduction of PCV10 and Hib conjugate vaccines nationwide. Microbiological diagnosis of AOM is not done on a routine basis in Bulgaria and this mild disease is underrepresented in our data set. Also, the tympanocentesis is not a common practice in our country. Thus, bacterial cultures studied here most likely represent cases of severe otitus media or patients with a complicated AOM.. The analysis included 128 S. pneumoniae isolates, of which 86% occurring in children aged ≤ 5 years. We found a relatively high rate of serotype 19F infections (20.3%), which is in accordance with the serotype distribution observed in the studies of AOM in German children [8], and the Finland [7]. Serotypes 6B and 19A were next most prominent, each comprising about 16% and 11%, respectively of the overall data set. The coverage calculations for the ...
Non-typeable Haemophihis influenzae (NTHi) is a significant cause of otitis media in children. We have employed single and multiple step electrospray ionization mass spectrometry (ESIMS) and NMR spectroscopy to profile and elucidate lipopolysaccharide (LPS) structural types expressed by NTHi strain 162, a strain obtained from an epidemiological study in Finland. ESIMS on O-deacylated LPS (LPS-OH) and core oligosaccharide (OS) samples of LPS provided information on the composition and relative abundance of glycoforms differing in the number of hexoses linked to the conserved inner-core element, L-alpha-D-Hepp-(1--, 2)-[PEtn --, 6]-L-alpha-D-Hepp-(1 --, 3)-L-alpha-D-Hepp-(1 --, 5)(.)[PPEtn --, 4]-alpha-Kdop-(2 --, 6)-Lipid A of H. influenzae LPS. The strain examined was found to elaborate Hex2 to Hex5 LPS glycoform populations having structures identical to those observed for H. influenzae strain Rd [Risberg, A.; Masoud, H.; Martin, A.; Richards, J.C.; Moxon, E.R.; Schweda, E.K.H. Eur. J Biochem. ...
Introduction to Annual Summary of Communicable Diseases, 2002. List of Reportable Diseases, 2002. Number of Cases of Selected Reportable Diseases, 2002. Fifty-six cases of invasive Haemophilus influenzae disease (1.2 per 100,000 population) were reported in 2001. Case-patients ranged in age from newborn to 89 years, (median, 63 years). Nineteen (34%) had pneumonia, 22 (39%) had bacteremia without another focus of infection, four (7%) had meningitis, and 11 (20%) had other conditions. Twelve (21%) deaths were reported among these cases.. Only one case was known to be type b (Hib), compared to three cases in 2000 and five cases in 1999. The Hib case reported in 2001 occurred in a 5-year-old with a complete vaccine history and no underlying medical conditions. Epiglottitis was the type of infection, and the patient survived. Nineteen (34%) of the Haemophilus influenzae isolates were not available for typing at MDH. Of the total 37 isolates for which typing was performed (including the one [3%] type ...
WHO/V&B/AVI Choosing the Right Vaccine WHOs Expanded Programme on Immunization (EPI) -Launched by WHO in 1974 -Initially 6 target diseases (TB, Diphtheria, Pertussis, Tetanus, Measles, Polio) -Hepatitis B added in 1991 -Hib added in 1998 (for those countries with moderate to high burden of Hib disease)
TY - JOUR. T1 - Regulation of virulence gene expression resulting from streptococcus pneumoniae and nontypeable haemophilus influenzae interactions in chronic disease. AU - Cope, Emily K.. AU - Goldstein-Daruech, Natalia. AU - Kofonow, Jennifer M.. AU - Christensen, Lanette. AU - McDermott, Bridget. AU - Monroy, Fernando. AU - Palmer, James N.. AU - Chiu, Alexander G. AU - Shirtliff, Mark E.. AU - Cohen, Noam A.. AU - Leid, Jeff G.. PY - 2011/12/5. Y1 - 2011/12/5. N2 - Chronic rhinosinusitis (CRS) is a common inflammatory disease of the sinonasal cavity mediated, in part, by polymicrobial communities of bacteria. Recent molecular studies have confirmed the importance of Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) in CRS. Here, we hypothesize that interaction between S. pneumoniae and NTHi mixed-species communities cause a change in bacterial virulence gene expression. We examined CRS as a model human disease to validate these polymicrobial interactions. Clinical ...
Planned administration/ administration of a vaccine not foreseen by the study protocol in the period starting 30 days before the first dose and ending 30 days after the last dose of vaccine, with the exception of any influenza vaccine which may be administered ≥ 15 days preceding or following any study vaccine dose ...
Introduction. Haemophilus parasuis is the causative agent of Glässers disease in swine, a disease characterised by fibrinous polyserositis, meningitis and polyarthritis (Li et al. 2009; Olvera, Segalés & Aragón 2007). In recent years, diseases in swine caused by H. parasuis have attracted worldwide attention (Baumann & Bilkei 2002). It is therefore necessary to carry out timely and effective monitoring of H. parasuis to identify strains circulating between farm animals as a means of defining the epidemiology and types of H. parasuis strains present in respective areas in order to control and prevent outbreaks.. Haemophilus parasuis is a slow-growing, fastidious organism with specific nutritional requirements, making its isolation difficult (Oliveira, Galina & Pijoan 2001). Moreover, detection of H. parasuis using conventional methods, including culture, biochemical or immunological assays is not effective and requires several days to complete (Angen et al. 2007). The polymerase chain ...
Developing a vaccine for Haemophilus influenzae serotype a: Proceedings of a workshop - CCDR: Volume 43-5, May 4, 2017: Implementation science
BACKGROUND: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. METHODS: This unique review highlights geographic differences in disease burden across certain countries in the African, Americas, Mediterranean, South-East Asian, and Western Pacific World Health Organization (WHO) regions, and relates this to vaccination coverage and local vaccine recommendations using the authors countries as illustrations. RESULTS: Substantial differences were observed in the incidence of these diseases and in vaccination coverage between the countries studied. Disease incidence often reflected inadequate surveillance, but also variable or poor vaccination coverage. Vaccination coverage against HepB was particularly low in the African and South-East Asian WHO regions; vaccination coverage against invasive Hib disease was low in these regions and in the Eastern Mediterranean and Western ...
The introduction of routine infant immunization with Haemophilus influenzae type b (Hib) conjugate vaccines in the United Kingdom in 1992 led to a significant reduction in invasive disease due to this organism. Subsequently, between 1999 and 2003 there was an increase in the number of immunized children with Hib infection. We investigated whether the rise in cases was related to changes in anti-polyribosylribitol phosphate (PRP) antibody concentration or avidity. Using stored sera, we analyzed temporal changes in antibody levels among 3- to 5-year-old children immunized between 1991 and 2000. Anti-PRP antibody concentrations were higher in 3- to 5-year-olds who received infant immunization in 1991 than those in subsequent years. This difference may be related to changes in either the mode of administration of Hib conjugate vaccines or the rates of Hib nasopharyngeal carriage. This study emphasizes the factors affecting anti-PRP antibody concentration following immunization with conjugate vaccines and
Haemophilus influenzae Antibody Does this test have other names? Haemophilus influenzae type b (Hib) IgG antibody level What is this test? This test measures the amount of anti-Hib IgG immunoglobulin, or antibody, in your blood. There are many types of Haemophilus influenza bacteria. They can live in your mouth, throat, ears, and airways and dont always cause illness. H. influenza type b (Hib) one of the most serious types. It doesnt cause the flu, although it has a similar-sounding name. It causes ba...
Objective-To characterize the genetic diversity of Haemophilus parasuis field isolates with regard to serovar, herd of origin, and site of isolation.. Sample population-Isolates of H parasuis obtained from pigs in 15 North American herds and multi-farm systems.. Procedure-98 H parasuis isolates were genotyped with the enterobacterial repetitive intergeneic consensus based-polymerase chain reaction (ERIC-PCR) technique and serotyped via agar gel precipitation test. Genomic fingerprints were analyzed and dendrograms were constructed to identify strains from the same serovar group, herd of origin, or isolation site and to evaluate the genetic variability within these categories.. Results-Serovar 4 (39%) and nontypeable (NT) isolates (27%) were most prevalent. Thirty-four distinct strains were identified among the 98 isolates, using a 90% similarity cutoff. Strains from serovar 4 and NT isolates had high genetic diversity (12 and 18 strains, respectively). One to 3 major clusters of prevalent ...
Liu, L., Chu, L., Liu, Q., Wang, C., Xia, Y. and Peng, Y. (2010) A Comparative Study on Biofilm Formation of Non-typeable Haemophilus influenzae and Pseudomonas aeruginosa under Single Culture or Co-Culture. African Journal of Microbiology Research, 4, 180-184.
Our investigation of a large collection of invasive NTHi isolates has allowed us to determine if particular LOS biosynthetic genes are present and have altered expression in sterile niches in the human host. While five out of seven of these biosynthetic genes (lic1A, lic3A, lic3B, lex2A, and lgtC) show no significant correlation with an ON or OFF expression state during invasive infection, we demonstrate that lic2A remains OFF in invasive isolates and oafA ON is statistically overrepresented in invasive isolates compared to the level in carriage isolates.. Our observation that lic2A is OFF in most invasive isolates is intriguing, as this finding appears contradictory to earlier results. Expression of lic2A was previously demonstrated to confer resistance to human serum (31), and modification of the NTHi LOS inner core with a galactose by Lic2A has been shown to shield the cells from in vitro neutrophil-mediated killing assays when lic1A is phase-varied OFF, with this modification being ...
Progress Toward Elimination of Haemophilus influenzae Type b Disease Among Infants and Children - United States, 1993-1994 -- Community Outbreak of Hemolytic Uremic Syndrome Attributable to Escherichia coli O111:NM - South Australia, 1995 -- Notice to Readers Licensure of Inactivated Hepatitis A Vaccine and Recommendations for Use Among International Travelers -- Notice to Readers Assessing Adult Vaccination Status at Age 50 Years ...
Haemophilus parasuis is known as a commensal organism discovered in the upper respiratory tract of swine where the pathogenic bacteria survive in various adverse environmental stress. QseC, a histidine protein kinase of the two-component regulatory systems CheY/QseC, is involved in the environmental adaptation in bacteria. To investigate the role of QseC in coping with the adverse environment stresses and survive in the host, we constructed a qseC mutant of H. parasuis serovar 13 strain(△qseC), MY1902. In this study, we found that QseC was involved in stress tolerance of H. parasuis, by the △qseC exhibited a decreased resistance to osmotic pressure, oxidative stress, and heat shock. Moreover, the △qseC weakened the ability to take up iron and biofilm formation. We also found that the QseC participate in sensing the epinephrine in environment to regulate the density of H.parasuis.
Haemophilus influenzae (tudi Pfeifferjev bacil) je vrsta hemofilusov[1], gramnegativnih pleomorfnih (polimorfnih) bacilov, to pomeni, da se njihova oblika prilagaja okolju, lahko postanejo bacili, kokobacili ali tudi vibriji. Je fakultativno anaerobna oportunistična bakterija, ki jo je prvi opisal Richard Pfeiffer leta 1892 med pandemijo gripe oziroma influence.[2] Sprva so zmotno predvidevali, da povzroča gripo, in sicer vse do leta 1933, ko so odkrili virus gripe. Haemophilus influenzae, pri 80% populacije, naseljuje nosno-žrelni predel (nasopharynx) in je del normalne mikrobne flore. Haemophilus influenzae (tipa B) povzroča različne lokalizirane in invazivne okužbe,[3] zlasti vnetja dihal, paranazalnih sinusov, srednjega ušesa, veznic, možganskih ovojnic, seroznih mren in sklepov, lahko pa tudi sepso. H. influenzae raste le na krvnem agarju in čokoladnem agarju, na katerega je cepljen tudi Staphylococcus aureus[1], s tem dodamo rastni faktor V (koencim ali NAD+) in X (hematin), pri ...
In the very recent past, Haemophilus influenzae type b (Hib) was what could truly be called a scourge to humanity. As recently as 1987, this particularly nasty bacterium caused invasive disease in a startling 1 of every 200 children in the U.S. under 5 years of age. Approximately two-thirds of these children developed meningitis, with a mortality rate of about 5%. Up to 30% of the survivors suffered permanent brain damage. Those children lucky enough to avoid meningitis developed pneumonia, septic arthritis, osteomyelitis, cellulitis, epiglottitis, or generalized sepsis. Fortunately I have never seen or treated a child with invasive disease due to Hib. Thats because I began my pediatric training in 1991 when vaccination against these horrendous diseases was just beginning. What was once a common and devastating menace to children, the dreaded nightmare of every pediatrician, was quickly brought to its knees. By 2006, the incidence of invasive Hib disease had been cut by 99%. Within a short ...
My research focuses on Streptococcus pneumoniae and non-typeable Haemophilus influenzae. The bacteria that I study asymptomatically colonize the respiratory tract of 10-50% of healthy individuals. While asymptomatic colonization is far more common than disease, S. pneumoniae and H. influenzae are important causes of bacterial infections in children and adults (e.g., otitis media, pneumonia, and exacerbations of chronic obstructive pulmonary disease (COPD)). Moreover, these infections are frequently, and controversially, treated with antibiotics. We use state-of-the-art methods that integrate clinical epidemiologic, and laboratory studies to elucidate factors that tip the balance between asymptomatic bacterial colonization and disease. Additional projects focus on how disruptions of homeostasis in the respiratory and gastrointestinal microbiota influence colonization resistance, development of antibiotic resistance, and risk of hospital-acquired infections. We use data and specimens from clinical ...
Convincing studies demonstrate significant protection during breastfeeding against diarrhoea, respiratory tract infections, otitis media, bacteraemia, bacterial meningitis, botulism, urinary tract infections and necrotizing enterocolitis. There is also good evidence for enhanced protection for years after the termination of breastfeeding against Haemophilus influenzae type b infections, otitis media, diarrhoea, respiratory tract infections and wheezing bronchitis. In some reports breastfeeding has also improved vaccine responses. Several studies show that milk may actively stimulate the immune system of the offspring via transfer of anti-idiotypic antibodies and lymphocytes. This may explain why breastfeeding diminishes the risk of developing coeliac disease. Some investigations suggest that there may also be a similar effect on allergic diseases and autoimmune diseases, as well as inflammatory bowel diseases and certain tumours. This needs to be confirmed.. ...
Erwin, A.L., Sandstedt, S.A., Bonthius, P.J., Geelhood, J.L., Nelson, K.L., Unrath, W.C.T., Diggle, M.A., Theodore, M.J., Pleatman, C.R., Mothershed, E.A., Sacchi, C.T., Mayer, L.W., Gilsdorf, J.R., Smith, A.L.. (2008). Evidence for clonality of non-typeable Haemophilus influenzae. Journal of Bacteriology 1473-83 ...
article{fc3e4d3f-eec5-4f6b-8f7e-bed105dc5dde, abstract = {,p,Non-typable Haemophilus influenzae (NTHi) are small, gram-negative bacteria and are strictly human pathogens, causing acute otitis media, sinusitis and community-acquired pneumonia. There is no vaccine available for NTHi, as there is for H. influenzae type b. Recent advances in proteomic techniques are finding novel applications in the field of vaccinology. There are several protein separation techniques available today, each with inherent advantages and disadvantages. We employed a combined proteomics approach, including sequential extraction and analytical two-dimensional polyacrylamide electrophoresis (2D PAGE), and two-dimensional semi-preparative electrophoresis (2D PE), in order to study protein expression in the A4 NTHi strain. Although putative vaccine candidates were identified with both techniques, 11 of 15 proteins identified using the 2D PE approach were not identified by 2D PAGE, demonstrating the complementarily of the ...
These Field Guides will help health workers in their efforts to control, eliminate, or eradicate diseases such as poliomyelitis, neonatal tetanus, yellow fever, diphtheria, pertussis, tetanus, Haemophilus influenzae type b infections, hepatitis B, measles, and rubella. The Field Guides also include standardized methods and procedures for conducting epidemiological surveillance and maintaining an up-to-date information system that makes it possible to take timely and effective decisions. These...
Characterization of intact lipopolysaccharides from the Haemophilus influenzae strain RM 118 using electrophoresis-assisted open-tubular liquid chromatography-mass spectrometry
Domain architecture and assignment details (superfamily, family, region, evalue) for gi|219871493|ref|YP_002475868.1| from Haemophilus parasuis SH0165. Plus protein sequence and external database links.
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This article discusses the epidemiology of invasive Haemophilus influenzae type b (Hib) disease and its prevention by vaccination for the period 1995 to 2005, comparing surveillance data for 1995-2000, when both PRP-OMP and HbOC vaccines were used, with 2000-2005, when only PRP-OMP vaccine was used.
The Virus and Its Effect Haemophilus influenzae (including Hib) is a bacterium that can cause a severe infection, occurring mostly in infants and children younger than five years of age. In spite of its name, Haemophilus influenzae does not cause influenza (the flu). There are six identifiable types of Haemophilus influenzae bacteria (a through f)…
Haemophilus influenzae rec-2 protein: homologous to comE-ORF3 gene product; involved in passing DNA through competent-cell envelope; isolated from Haemophilus influenzae; amino acid sequence in first source; GenBank L20805
Characterization of novel structure features in the lipopolysaccharide of non-disease assciated nontypeable Haemophilus influenzae .