A personal story video (video transcript) on their experiences of lung cancer which can be helpful if you have been diagnosed with lung cancer.

HEADER RNA BINDING PROTEIN 22-NOV-99 1DG1 TITLE WHOLE, UNMODIFIED, EF-TU(ELONGATION FACTOR TU). COMPND MOL_ID: 1; COMPND 2 MOLECULE: ELONGATION FACTOR TU; COMPND 3 CHAIN: G, H; COMPND 4 SYNONYM: EF-TU SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; SOURCE 3 ORGANISM_TAXID: 562; SOURCE 4 OTHER_DETAILS: CELL CYTOPLASM EXTRACT KEYWDS ELONGATION FACTOR, TRNA BINDING, ALPHA BETA SHIFT, TS KEYWDS 2 BINDING PROTEIN, GTPASE, GDP BINDING, RNA BINDING PROTEIN EXPDTA X-RAY DIFFRACTION AUTHOR K.ABEL,M.YODER,R.HILGENFELD,F.JURNAK REVDAT 4 24-FEB-09 1DG1 1 VERSN REVDAT 3 01-APR-03 1DG1 1 JRNL REVDAT 2 29-MAR-00 1DG1 1 REMARK REVDAT 1 01-DEC-99 1DG1 0 JRNL AUTH K.ABEL,M.D.YODER,R.HILGENFELD,F.JURNAK JRNL TITL AN ALPHA TO BETA CONFORMATIONAL SWITCH IN EF-TU. JRNL REF STRUCTURE V. 4 1153 1996 JRNL REFN ISSN 0969-2126 JRNL PMID 8939740 JRNL DOI 10.1016/S0969-2126(96)00123-2 REMARK 1 REMARK 2 REMARK 2 RESOLUTION. 2.50 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : X-PLOR REMARK 3 ...

tuf2; recname: full=elongation factor tu 2; short=ef-tu 2; recname: full=elongation factor tu 2; short=ef-tu 2; K02358 elongation factor ...

rso:RSc3041 K02358 elongation factor Tu , (GenBank) tuf2; probable elongation factor tu (ef-tu protein) (A) MAKEKFERTKPHVNVGTIGHVDHGKTTLTAAIATVLSSKFGGEAKKYDEIDAAPEEKARG ITINTAHIEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHI LLARQVGVPYIIVFLNKCDMVDDAELLELVEMEVRELLSKYDFPGDDTPIIKGSAKLALE GDKGELGEVAIMNLADALDSYIPTPERAVDGTFLMPVEDVFSISGRGTVVTGRIERGIIK VGEEIEIVGIKATQKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREDVERGQVLCKPGS IKPHTHFTGEVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGSIELPKDKEMVMPGDNVS ITVKLIAPIAMEEGLRFAIREGGRTVGAGVVAKIIE ...

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An epitope of elongation factor Tu (EF-Tu), which is found in organisms in both the bacterial and archaeal domains, was recently defined by mAb 900. To localize the conserved epitope within the EF-Tu molecule and to determine its sequence, SPOTScan analysis of synthetic peptides, Western blot analysis of purified EF-Tu domains and site-directed mutagenesis studies were used. Analysis of mAb 900 binding to overlapping 15-mer peptides encompassing the complete sequence of EF-Tu of Escherichia coli was inconclusive, suggesting three distinct regions may be epitopes. Western blot analysis of EF-Tu domains 1-3 of Thermus thermophilus suggested that the epitope was located at the N terminus. This was confirmed by site-directed mutagenesis of EF-Tu domain 1 of Mycoplasma hominis. By C-terminal truncation of the N-terminal 15-mer peptide the epitope was mapped to EF-Tu residues 1-6. Replacement of each of the residues in the epitope peptide demonstrated that only positions 5 and 6 were indispensable for

Electron paramagnetic resonance spectroscopy has been used to obtain information on the structure and stability of the products of GTP cleavage at the active site of elongation factor Tu (EF-Tu) from Bacillus stearothermophilus. Using stereospecifically labelled (Sp)-(Rp)-[beta-17O]GTP (prepared by modification of a previously published procedure which is now also suitable for guanine nucleotides), it was found that only one of the two possible diastereomers (Sp) led to detectable line-broadening of the EPR spectrum of Mn2+ at the active site of EF-Tu (linewidth 1.5 mT), whereas the Rp isomer caused the same linewidth as unlabelled nucleotide (1.3 mT). From our earlier work and from a demonstration that the lifetime of the state giving the broadened spectrum is too long to be assigned to the EF-Tu.GDP.Mn complex [the rate constant for decay as measured by displacement of GDP by the fluorescent 2(3)-O-(N-methylanthraniloyl)-GDP is 6.2 x 10(-3) s-1 at 25 degrees C and pH 6.8], we conclude that ...

Staphylococcus aureus; strain: USA300_FPR3757; locus tag: SAUSA300_RS02850 (SAUSA300_0533); symbol: tuf; product: elongation factor Tu

Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical studies have described the complex interactions needed to effect canonical function. However, EF-Tu has evolved the capacity to execute diverse functions on the extracellular surface of both eukaryote and prokaryote cells. EF-Tu can traffic to, and is retained on, cell surfaces where can interact with membrane receptors and with extracellular matrix on the surface of plant and animal cells. Our structural studies indicate that short linear motifs (SLiMs) in surface exposed, non-conserved regions of the molecule may play a key role in the moonlighting functions ascribed to this ancient, highly abundant protein. Here we explore the diverse moonlighting functions relating to pathogenesis of EF-Tu in bacteria and examine putative SLiMs on surface-exposed regions of the molecule.

Addresses: Bilgin N, Univ Uppsala, Ctr Biomed, Dept Biochem, Box 576, S-75123 Uppsala, Sweden. Uppsala Univ, Ctr Biomed, Dept Biol Mol, S-75124 Uppsala, Sweden. Inst Biol Struct, F-38027 Grenoble 1, France. DESY, European Mol Biol Lab, D-22603 Hamburg, GeAvailable from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14 ...

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Central Telephone Exchange Tel.: +49 351 463-0 Postal address of the TU Dresden The use of the postal address of the TU Dresden is explained on a separate website. The deadline PO Box of TU …

Author(s): Eccleston, JF; Gratton, E; Jameson, DM | Abstract: A fluorescent derivative of GDP was prepared by the reaction of 2-amino-2-deoxy-GDP with fluorescamine. This derivative binds tightly (KD approximately 4.5 X 10(-8) M) to elongation factor Tu (EF-Tu) from Escherichia coli. The emission properties, including spectra, polarizations, and lifetimes, for fluorescamine-GDP free in solution and bound to EF-Tu are presented. Emission data on the fluorescamine-ethylamine conjugate are also given. A multifrequency phase and modulation lifetime study (using nine modulation frequencies over the range of 2-80 MHz) indicated that the emissions of these three systems were well characterized by single exponential decays corresponding to 1.45 ns for the fluorescamine-ethylamine derivative in buffer and to 7.74 and 11.03 ns for the fluorescamine-GDP derivative free in buffer and bound to EF-Tu, respectively. Multifrequency differential polarized phase fluorometry results indicated a rotational relaxation

Elongation factor Tu, domain 2;Molecular Function: GTP binding (GO:0005525); Elongation factor G, III and V; Small GTP-binding protein domain;Molecular Function: GTP binding (GO:0005525); Elongation factor G, C-terminal;Molecular Function: GTP binding (GO:0005525); GTP-binding protein LepA;Molecular Function: GTP binding (GO:0005525); Protein synthesis factor, GTP-binding;Molecular Function: GTP binding (GO:0005525), Biological Process: protein biosynthesis (GO:0006412 ...

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Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [PUBMED:11297922, PUBMED:11290319]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to ...

1ETU: Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

PD mutations in the RocCOR domain of LRRK2 lead to a decrease in GTPase activity [23,25,43,44,56-58], although the affected residues are most often not directly located in the GTP/GDP-binding pocket [37,46]. Using the bacterial CtRoco as a model, we previously showed that the RocCOR domain needs to cycle between a dimeric and monomeric state during the GTPase reaction, where GTP binding induces monomerization while the protein re-dimerizes after GTP hydrolysis [36]. This mechanism thus predicts that either mutations that stabilize the dimer or that block the protein in a monomeric state would impair the GTPase reaction. We concomitantly showed that the L487A mutation (corresponding to the PD-associated mutation I1371V in LRRK2) leads to a decrease in GTP turnover and stabilizes the CtRoco dimer. In agreement with these findings and with our model, it was very recently reported that the R1441G/C/H and N1473H PD mutations decrease the GTPase activity of the Roc domain of LRRK2 by destabilizing or ...

1KTV: A New Crystal Form of Thermus thermophilus Elongation Factor G Indicates Crystallographic Limitations Imposed on Molecular Flexibility

ef-tu; highly similar to elongation factor Tu from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp,A6TEX7); K02358 elongation factor ...

In urdir fur Boblocel cuansilong tu bi iffictovi, e cuansilur mast bi cumplitily priperid tu wurk on thi monostry uf hilpong uthirs. Biyund thi wurldly chellingis, e Chrostoen cuansilur elsu fecis hamenostoc thirepiatoc felsi voiws uf sicaler thirepy. Chrostoen cuansilurs meonteon e fucel puont on gaodong piupli tu lovong e lofi thet os fall uf sporotael rochniss end metaroty. Yit, sicaler thirepost fucasis un silf-gretofocetoun end silf-ectaelozetoun. As Chrostoen monostry hilpirs, yua mast bi lovong by thi trath end iximplofy e Chrost-cintirid lofi. Crebb (1977) divilupid e cuansilong mudil thet tiechis as huw tu divilup ondovodaelozid lofi meps thet woll gaodi piupli tu sporotael gruwth, metaroty, end e lung-lovid Chrost-cintirid lofi. It os issintoel es Chrostoen cuansilurs wi eri ebli tu brong piupli tu andirstend thet thi ilacodetoun tu thior prublims Gud hes thi enswir prierrengid scroptarelly. Farthirmuri, inloghtin thi cloint thet thior onclasovi sicaroty os on Chrost Jisas thet uar ...

Hielth onfurmetoun hes biin ixprissid es thi fuandetoun fur bittir hielth verouasly. Huwivir, thi hielth onfurmetoun foild os tuu cumplix. Thi dospirsid hielthceri dete, whoch os thi meon prublim, hevi ettrectid thi ettintoun uf meny risierchirs. Farthirmuri, dai tu thi veroid netari uf hielthceri dete, ot hes bicumi mach cumplocetid tesk tu ixemoni end enelyzi thi hielthceri riletid dete. Hinci, thiri os e niid fur rubast, ontillogint end suphostocetid mithuds tu meki thi lergi emuant uf dete andirstendebli eatumetocelly. Addotounelly, midocel scoinci os e gruwong pruciss, whoch os biong apdetid tomi tu tomi. Thirifuri, ixostong hielth ceri dete niid tu bi enelyzid tu ubteon midocel pethweys ur trietmint mithuds tu andirstend thim end pussobly ompruvi thim tu en ixtint ...

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CM suka makan lemak nangka ni tapi jaang sangat masak sebab takut terpilih nangka yang keras dan liat. Kalau dapat jenis lebut tu memang makan tak ingat dunia la. Tapi lepas tu ....angin kus kus pulak maii..he he. ReplyDelete ...

Encuentra todo lo referente a tu kymco Xciting, variador, escape, noticias, manuales, foro, compra venta, accesorios, tuning, mejoras, inventos, fotos, v deos, rutas, quedadas y mucho m s... -

Villa, E., Sengupta, J., Trabuco, L. G., Lebarron, J., Baxter, W. T., Shaikh, T. R., Grasucci, R. A., Nissen, P., Ehrenberg, M., Schulten, K. & Joachim, F. (2009). Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America, 106(1), 1063-1068 ...

SWISS-MODEL Repository entry for Q03MW6 (EFTS_STRTD), Elongation factor Ts. Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)

Ribosomal elongation factor 4 (EF4) is highly conserved among bacteria, mitochondria, and chloroplasts. However, the EF4-encoding gene, lepA, is nonessential an

d - 31.75 mm. D - 68,262 mm. T - 22,225 mm. B - 22,225 mm. C - 17,462 mm. R - 3,6 mm. r - 1,5 mm. a - -5,1 mm. Da - 63 mm. db - 44,5 mm. da - 38,5 mm. Db - 59 mm. Aa - 1,2 mm. Ab - 0,9 mm. Weight - 0,37 Kg. Basic static load rating (C0) - 70,2 kN. Factor (G1) - 17,5. Factor (G2) - 8,5. Factor (Cg) - 0,0164. Factor (K) - 1,4. Basic dynamic load rating (C90) - 15,3. Basic dynamic load rating (Ca90) - 10,9. Basic dynamic load rating (C1) - 59,1 kN. Calculation factor (e) - 0,42. Calculation factor (Y) - 1,44. ...

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The Gtr1 protein of Saccharomyces cerevisiae is a member of the RagA subfamily of the Ras-like small GTPase superfamily. Gtr1 has been implicated in various cellular processes. Particularly, the Switch regions in the GTPase domain of Gtr1 are essential for TORC1 activation and amino acid signaling. Therefore, knowledge about the biochemical activity of Gtr1 is required to understand its mode of action and regulation. By employing tryptophan fluorescence analysis and radioactive GTPase assays, we demonstrate that Gtr1 can adopt two distinct GDP- and GTP-bound conformations, and that it hydrolyses GTP much slower than Ras proteins. Using cysteine mutagenesis of Arginine-37 and Valine-67, residues at the Switch I and II regions, respectively, we show altered GTPase activity and associated conformational changes as compared to the wild type protein and the cysteine-less mutant. The extremely low intrinsic GTPase activity of Gtr1 implies requirement for interaction with activating proteins to support its

Complete information for EFTUD1P1 gene (Pseudogene), Elongation Factor Tu GTP Binding Domain Containing 1 Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Scotti, JS and Leung, IKH and Ge, W and Bentley, MA and Paps, J and Kramer, HB and Lee, J and Aik, W and Choi, H and Paulsen, SM and Bowman, LAH and Loik, ND and Horita, S and Ho, CH and Kershaw, NJ and Tang, CM and Claridge, TDW and Preston, GM and McDonough, MA and Schofield, CJ (2014) Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proceedings of the National Academy of Sciences of the United States of America, 111 (37). 13331 - 13336. ISSN 0027-8424 ...

24 Finał Wielkiej Orkiestry Świątecznej Pomocy już 10 stycznia. Przygotowania do dwóch dni finału w Ząbkowicach Śląskich (sportowej soboty i niedzielnego finału) trwają w najlepsze. Pojawiły się także orkiestrowe aukcje ząbkowickiego sztabu na  allegro. Można tam licytować prawdziwe perełki:  płytę BRACIA: "Zmienić zdarzeń bieg" z

Hier finden Sie die Lehrveranstaltungen der Biopsychologie mit Lehrmaterialien, Informationen zu Prüfungen und Abschlussarbeiten in unserer Abteilung. mehr erfahren zu: Lehrveranstaltungen …

Tuğba Eray Biber, Karadeniz Rumları ve Yunanistan, İstanbul: Yeditepe Yayınları, 2016, XXXIV+315 s., ISBN: 978-605-9787-49-9 ...

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Molecular model of elongation factor complexed with GDP (guanosine diphosphate). This enzyme is involved in the elongation of polypeptide chains during translation, the production of a protein from an mRNA (messenger ribonucleic acid) template. - Stock Image C025/1936

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