With a fatality rate as high as 90% the Ebola virus or Ebola haemorrhagic fever has been endemic of regions in Central Africa for years. The recent outbreak
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Ultrastructure of the AgB oligomers analyzed by TEM.TEM images from rAgB8/1 (A), rAgB8/2 (B), rAgB8/3 (C), and AgB (D) oligomers. Recombinant AgB subunits were
The Arabidopsis thaliana heterotrimeric G protein complex is encoded by single canonical Galpha and Gbeta subunit genes and two Ggamma subunit genes (AGG1 and AGG2), raising the possibility that the two potential G protein complexes mediate different cellular processes. Mutants with reduced expression of one or both Ggamma genes revealed specialized roles for each Ggamma subunit. AGG1-deficient mutants, but not AGG2-deficient mutants, showed impaired resistance against necrotrophic pathogens, reduced induction of the plant defensin gene PDF1.2, and decreased sensitivity to methyl jasmonate. By contrast, both AGG1- and AGG2-deficient mutants were hypersensitive to auxin-mediated induction of lateral roots, suggesting that Gbetagamma1 and Gbetagamma2 synergistically inhibit auxin-dependent lateral root initiation. However, the involvement of each Ggamma subunit in this root response differs, with Gbetagamma1 acting within the central cylinder, attenuating acropetally transported auxin signaling, ...
... is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008 ...
Objective: 1α,25-dihydroxyvitamin D3 (1,25D3) regulates cells via two different mechanisms: VDR-dependent gene transcription and rapid membrane-signaling. In membrane-signaling, phospholipase-A2 (PLA2) is activated after 1,25D3 binds its membrane-associated receptor, protein disulfide isomerase family A, member 3 (Pdia3), leading to release of arachidonic acid, activation of phospholipase C (PLC), and activation of PLC-dependent protein kinase C (PKC). Caveolae are required for 1,25D3-dependent PKC activation. PLA2 activating protein (PLAA), which activates PLA2, exhibits homology with the G-protein beta subunit, and was considered to play a role in this process. The aim of the present study was to evaluate if and how PLAA mediates the membrane effects of 1,25D3. Method: Subconfluent cultures of MC3T3-E1 cells immunostained against PLAA, Cav-1 and Pdia3 were imaged using confocal microscopy. Wild type and PLAA-silenced (shPLAA) MC3T3-E1 osteoblasts were treated with either vehicle or 1,25D3; ...
Predicted to have G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; regulation of G protein-coupled receptor signaling pathway; and regulation of postsynaptic membrane potential. Localizes to several cellular components, including the dendrite terminus; glutamatergic synapse; and postsynaptic membrane. Is expressed in bone; foot mesenchyme; nervous system; pelvic girdle skeleton; and sensory organ. Orthologous to human RGS7 (regulator of G protein signaling 7 ...
Ric-8A and Ric-8B are positive regulators of heterotrimeric G protein a subunit function. We have recently defined the cellular action of Ric-8 proteins towards...
Humrich J، Bermel C، Bünemann M، وآخرون. (2005). "Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding.". J. Biol. Chem. 280 (20): 20042-50. PMID 15745879. doi:10.1074/jbc.M409233200. ...
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular ...
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular ...
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular ...
ID M9PBC0_DROME Unreviewed; 2023 AA. AC M9PBC0; DT 26-JUN-2013, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 1. DT 22-NOV-2017, entry version 39. DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256,RuleBase:RU003808}; GN Name=Ca-alpha1D {ECO:0000313,EMBL:AGB93018.1, GN ECO:0000313,FlyBase:FBgn0001991}; GN Synonyms=alpha1 {ECO:0000313,EMBL:AGB93018.1}, alpha1D GN {ECO:0000313,EMBL:AGB93018.1}, BG:DS02795.1 GN {ECO:0000313,EMBL:AGB93018.1}, Ca-_1D {ECO:0000313,EMBL:AGB93018.1}, GN Ca-a1D {ECO:0000313,EMBL:AGB93018.1}, Ca-alpha1 GN {ECO:0000313,EMBL:AGB93018.1}, ca-alpha1D GN {ECO:0000313,EMBL:AGB93018.1}, ca-alpha1d GN {ECO:0000313,EMBL:AGB93018.1}, Ca-alpha[[1]]D GN {ECO:0000313,EMBL:AGB93018.1}, Ca_alpha1D GN {ECO:0000313,EMBL:AGB93018.1}, Caalpha1D GN {ECO:0000313,EMBL:AGB93018.1}, cad {ECO:0000313,EMBL:AGB93018.1}, caID GN {ECO:0000313,EMBL:AGB93018.1}, DmCa1alpha1 GN {ECO:0000313,EMBL:AGB93018.1}, DmCa1D {ECO:0000313,EMBL:AGB93018.1}, GN ...
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We identified the transcription factor E2F8 in the course of a screen for novel activators of heterotrimeric G proteins. In S. cerevisiae, E2F8 was able to activate a G protein/MAP kinase reporter pathway; this activity was specific for particular G protein isoforms, mapped epistatically to the level of heterotrimers, and was antagonized by a GTPase-accelerating protein. The amino-terminus of the protein appeared to be most important for G protein activation. The most parsimonious interpretation of these results is that E2F8 stimulates nucleotide exchange on the α subunit of heterotrimeric G proteins. Since E2F8 did not reduce the maximal receptor-mediated signal (Figure 2), but rather caused a left-shift in the receptors dose-response curve, E2F8 does not compete with receptors for G proteins. Instead, E2F8 and receptors may be complementary to one another in their mode of action, using different molecular mechanisms to activate Gα.. G protein activation would be a novel function for an E2F ...
In the yeast Saccharomyces cerevisiae, the G protein beta gamma subunits are essential for pheromone signaling. The Galpha subunit Gpa1 can also promote signaling, but the effectors in this pathway are not well characterized. To identify candidate Gpa1 effectors, we expressed the constitutively active Gpa1(Q323L) mutant in each of nearly 5000 gene-deletion strains and measured mating-specific responses. Our analysis reveals a requirement for both the catalytic (Vps34) and regulatory (Vps15) subunits of the sole phosphatidylinositol 3-kinase in yeast. We demonstrate that Gpa1 is present at endosomes, where it interacts directly with both Vps34 and Vps15 and stimulates increased production of phosphatidylinositol 3-phosphate. Notably, Vps15 binds to GDP-bound Gpa1 and is predicted to have a seven-WD repeat structure similar to that of known G protein beta subunits. These findings reveal two new components of the pheromone signaling pathway. More remarkably, these proteins appear to comprise a ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Complete information for GNB3 gene (Protein Coding), G Protein Subunit Beta 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
The phosphorylation of heptahelical receptors by heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor kinases (GRKs) is a universal regulatory mechanism that leads to desensitization of G protein signaling and to the activation of alternative signaling pathways.We determined the crystallographic structure of bovine GRK2 in complex with G protein beta1gamma2 subunits.Our results show how the three domains of GRK2-the RGS (regulator of G protein signaling) homology, protein kinase, and pleckstrin homology domains-integrate their respective activities and recruit the enzyme to the cell membrane in an orientation that not only facilitates receptor phosphorylation, but also allows for the simultaneous inhibition of signaling by Galpha and Gbetagamma subunits ...
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene ...
Dr. Akinori Yoda is a geneticist and MDS researcher who earned his PhD in Molecular Biology and Genomics. He currently works with cancer researcher David Weinstock, MD at the Weinstock Laboratory at Dana-Farber Cancer Institute. His recent research article, Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance. will soon be published in the prestigious scientific journal Nature.
TY - JOUR. T1 - The active role of βγ in signal transduction. AU - Sternweis, Paul C.. PY - 1994. Y1 - 1994. N2 - Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the α-subunits of G proteins as the pathway for downstream regulation, very active roles for the βγ-subunits have emerged in the past year. Recent experiments highlight the versatility of βγ-subunits in these regulatory pathways, but also emphasize some fundamental questions that remain.. AB - Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the α-subunits of G proteins as the pathway for downstream regulation, very active roles for the βγ-subunits have emerged in the past year. Recent experiments highlight the versatility of βγ-subunits ...
The G Protein is involved in production of Cyclic AMP or cAMP from ATP. This is the major process behind the G Protein. cAMP is actually a second messenger and goes ahead to perform its function ...
Summary is not available for the mouse gene. This summary is for the human ortholog.] Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008 ...
PRF readers can get free access to a selected Journal of Pain paper each month, thanks to the American Pain Society. Get the free full text of the selection from the December 2017 issue here.. ...
This resource is meant to serve as a centralized repository of information for modeling the pheromone response pathway, and contains an embedded computational model of the pheromone response pathway that anybody in the community can use. As a community resource, anyone can sign up for an account and contribute. ...
Complete information for GNAL gene (Protein Coding), G Protein Subunit Alpha L, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
14-3-3 gamma is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways,…
14-3-3 gamma is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways,…
Comparada con la anestesia general inhalatoria (AGI), a la anestesia total intravenosa (ATIV) se le han atribuido ventajas como son el despertar m s predecible, una recuperaci n m s temprana del estado de conciencia y de funciones psicomotoras y la baja incidencia de n usea y v mito postoperatorio. Comparamos los tiempos de despertar con el uso de dos t cnicas anest sicas AGB y ATIV usando propofol y sevoflorano, en dosis equipotentes. REFERENCIAS (EN ESTE ART CULO) ...
GNB2兔单克隆抗体[EPR3261Y](ab81272)可与小鼠, 大鼠, 人样本反应并经WB, IP, IHC, ICC, Flow Cyt实验严格验证并得到1个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTIL 1 - 70 AQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVML 71 - 140 QSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSAPAPQVFLQATREESRILLQDLSSSA 141 - 210 PHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECENGSYKPG 211 - 280 WLVTLSSAIYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAY 281 - 350 ECICKAGFYHPGVLPVNNFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAI 351 - 420 ISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLL 421 - 490 GFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEKQISLIG 491 - 560 QGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAFHEPRYMAVAVHNELIISAIFHTI 561 - 630 RFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSI 631 - 700 NSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCS 701 - 770 KEDKEGADHGTAKGTALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQE 771 - 840 ...
Online Cover This week features a Research Article that shows that G protein α subunits in Arabidopsis can function independently of guanine nucleotide exchange. The image shows fluorescence-based detection of the plasma membrane localization of different G protein subunits in Nicotiana benthamiana leaves. [Image: Maruta et al./Science Signaling] ...
GNG12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 92 aa (1-69 a.a) and having a molecular mass of 10.1kDa.
Mutually exclusive mutations affecting exon 4, codon 183 or exon 5, codon 209, of the G protein α-subunit Q (GNAQ) gene and the G protein α-subunit 11 (GNA11) gene are found in approx 84% of uveal melanomas. The identification of the mutational profile of exons 4 and 5 of GNAQ/GNA11 will facilitate improvement in our knowledge of these neoplasms, and may be useful for selection of patients for targeted therapeutic approaches. ...
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.. ...
Plasmid p-eGFP-beta 2 CP from Dr. John Coopers lab contains the insert capping protein beta 2 subunit and is published in J Cell Biol. 1998 Dec 28. 143(7):1919-30. This plasmid is available through Addgene.
Sapporo, Japan (SPX) Jul 26, 2016 - Scientists at Hokkaido University have revealed temperature-dependent energy-state conversion of molecular hydrogen on ice surfaces, suggesting the need for a reconsideration of molecular evolution
The National MS Societys Everyday Matters, supported by Genzyme, a Sanofi company, was an interactive national project that uncovered stories of real people facing the everyday challenges that MS can bring on the path to ones best life.
Sst2 is the prototype for the newly recognized RGS (for regulators of G-protein signaling) family. Cells lacking the pheromone-inducible SST2 gene product fail to resume growth after exposure to pheromone. Conversely, overproduction of Sst2 markedly enhanced the rate of recovery from pheromone-induced arrest in the long-term halo bioassay and detectably dampened signaling in a short-term assay of pheromone response (phosphorylation of Ste4, Gbeta subunit). When the GPA1 gene product (Galpha subunit) is absent, the pheromone response pathway is constitutively active and, consequently, growth ceases. Despite sustained induction of Sst2 (observed with specific anti-Sst2 antibodies), gpa1delta mutants remain growth arrested, indicating that the action of Sst2 requires the presence of Gpa1. The N-terminal domain (residues 3 to 307) of Sst2 (698 residues) has sequence similarity to the catalytic regions of bovine GTPase-activating protein and human neurofibromatosis tumor suppressor protein; segments ...
Berlin, S., Hadad, E., Heled, Y., and Moran, D.S. (2004). The Efficacy of Nutritional Supplements upon Physical Exercise. Journal of Israeli Military Medicine 1(2), 72-80.. Berlin, S., Shalit, L., Yarom, Y., and Moran, D.S. (2007). Metabolic rate prediction by massless actigraphy for outdoor activities. Mil Med 172, 882-887.. Eliyahu, U., Berlin, S., Hadad, E., Heled, Y., and Moran, D.S. (2007). Psychostimulants and military operations. Mil Med 172, 383-387.. Rubinstein, M., Peleg, S., Berlin, S., Brass, D., and Dascal, N. (2007). Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes. J Physiol 581, 17-32.. Berlin S. (2009). Do bigger and "better" labs have easier access to high impact factor journals? Science signaling. December 9th, E-letter. http://stke.sciencemag.org/content/2/99/eg15.e-letters (Addition to Living by The Numbers- Michael B. Yaffe; 01 Dec 2009: Vol. 2, Issue 99, pp. eg15, doi: 10.1126/scisignal.299eg15).. Lvov, ...
The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. It is one of the three main families of G proteins: Gαi/Gαo, Gαq, and Gαs.[1] A mnemonic for remembering this subunit is to look at the first letter (Gαs = Adenylate Cyclase stimulator). ...
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Stars in the asymptotic giant branch (AGB) are in the penultimate stage of their lives as low- mass dwarfs. During this stage, they produce in their cool, bloated envelopes vast quantities of dust composed from metals ...
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