Rabbit polyclonal antibody raised against synthetic peptide of GNAI1/GNAI2. A mixture of synthetic peptides corresponding to amino acids 345-354 of GNAI1 and 346-355 of GNAI2. (PAB9893) - Products - Abnova
Complete information for GNAI2 gene (Protein Coding), G Protein Subunit Alpha I2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates ...
Romanelli Tavares VL, Gordon CT, Zechi-Ceide RM, Kokitsu-Nakata NM, Voisin N, Tan TY, Heggie AA, Vendramini-Pittoli S, Propst EJ, Papsin BC, Torres TT, Buermans H, Capelo LP, den Dunnen JT, Guion-Almeida ML, Lyonnet S, Amiel J, Passos-Bueno MR. Novel variants in GNAI3 associated with auriculocondylar syndrome strengthen a common dominant negative effect. Eur J Hum Genet. 2015 Apr; 23(4):481-5 ...
Chicken polyclonal GNAI3 antibody validated for WB, ICC and tested in Human, Mouse, Rat, Chk and Gpig. Immunogen corresponding to synthetic peptide
بیوگاز یکی از منابع تجدید پذیر انرژی است که توسط باکتری-هایی که موجب تجزیه مواد آلی در شرایط بی-هوازی می‌گردند، تولید می-شود. به منظور تصمیم‌گیری در مورد انتخاب مکان-های مناسب راه اندازی واحد-های بیوگاز، سهولت دسترسی به ضایعات آلی و تخمین مقدار آن-ها حائز اهمیت است. در پژوهش حاضر با بهره گیری از اطلاعاتی نظیر تراکم جمعیت روستایی و جمعیت دام در منطقه و نقشه-های کاربری اراضی، مدلی برای تعیین پتانسیل تولید بیوگاز از فضولات دامی و پسماند-های روستایی، پراکنش آن در سطح استان کردستان و تعیین نقاط مستعد برای احداث واحدهای بیوگاز با استفاده از سیستم اطلاعات
Expression of GNAI3 (87U6) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
gnai3 gene expression in Bgee. Bgee allows to automatically compare gene expression patterns between species, by referencing expression data on anatomical ontologies, and designing homology relationships between them.
The effect of endogenous RGS proteins on receptor-mediated signaling has been studied in various systems by expressing RGS-insensitive or -sensitive Gαo (Jeong and Ikeda, 2000; Boutet-Robinet et al., 2003; Clark et al., 2003). Insensitivity of Gαo to endogenous RGS proteins increases receptor signaling to some, but not all, pathways that have been studied. In this work we have expressed RGS-insensitive and -sensitive Gαo in C6 glioma cells expressing the rat μ-opioid receptor. This allowed us to test two hypotheses, namely, that coupling of the μ-opioid receptor to Gαo can provide for adenylyl supersensitization and that RGS proteins decrease the degree of supersensitization because of their effect in shortening the lifetime of the active signaling molecule Gαo-GTP and its Gβγ counterpart. The results show the presence of active Gαo alone allows for the development of μ-opioid agonist-mediated adenylyl cyclase supersensitization and that this effect is greatly enhanced when Gαo is ...
PMID 16565233] A -318 C,G single-nucleotide polymorphism in the GNAI2 gene promoter region is associated with high blood pressure in Caucasians from Italy. Note: this SNP does not appear to have a corresponding entry in dbSNP ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene. G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. RGS19 has been shown to interact with GNAO1, GIPC1, OSTM1, GNAI1, GNAI3 and GNAZ. GRCh38: Ensembl release 89: ENSG00000171700 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000002458 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916-20. doi:10.1073/pnas.92.25.11916. PMC 40514 . PMID 8524874. "Entrez ...
The RT² qPCR Primer Assay is the most reliable SYBR® Green-based quantitative real-time PCR assay for gene expression analysis. Our experimentally verified design algorithm yields gene-specific qPCR assays characterized by uniform and high PCR efficiencies and standardized amplification conditions. Every RT² Primer Assay is subjected to rigorous experimental verification. Single product amplification of the correct size and high PCR efficiency are guaranteed when using the appropriate RT² qPCR Master Mixes. The uniform PCR amplification efficiencies and PCR conditions of the RT² qPCR Primer Assays provide an accurate and scalable solution for multiple gene expression analyses. Browse Primer Assays By Gene ...
TY - JOUR. T1 - Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. AU - Qi, Xiaofeng. AU - Liu, Heng. AU - Thompson, Bonne. AU - McDonald, Jeffrey. AU - Zhang, Cheng. AU - Li, Xiaochun. PY - 2019/1/1. Y1 - 2019/1/1. N2 - The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncogene (GLI) transcription factors, which activates the Hedgehog signalling pathway1,2. It has remained unknown how PTCH1 modulates SMO, how SMO is stimulated to form a complex with heterotrimeric G proteins and whether G-protein coupling contributes to the activation of GLI proteins3. Here we show that 24,25-epoxycholesterol, which we identify as an endogenous ligand of PTCH1, can stimulate Hedgehog signalling in cells and can trigger G-protein signalling via human SMO in vitro. We present a cryo-electron microscopy structure of human SMO ...
The auriculocondylar syndrome NGS panel consists of three genes: EDN1, GNAI3 and PLCB4.. Copy number variation (CNV) analysis of the auriculocondylar syndrome genes is also offered as a panel. Additionally, CTGT offers a comprehensive test (both NGS and CNV panels) for these genes. Panel genes are also offered as individual sequencing and deletion/duplication tests, unless otherwise indicated.. ...
Complete information for GNAL gene (Protein Coding), G Protein Subunit Alpha L, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
GNG12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 92 aa (1-69 a.a) and having a molecular mass of 10.1kDa.
G protein alpha S兔多克隆抗体(ab97629)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
There are no specific protocols for Recombinant Rat G protein alpha (mutated Q212 L + D280 N) (ab90410). Please download our general protocols booklet
Eesti Teadusinfosüsteem koondab informatsiooni teadus- ja arendusasutuste, teadlaste, teadusprojektide ning erinevate teadustegevuste tulemuste kohta.
Mutually exclusive mutations affecting exon 4, codon 183 or exon 5, codon 209, of the G protein α-subunit Q (GNAQ) gene and the G protein α-subunit 11 (GNA11) gene are found in approx 84% of uveal melanomas. The identification of the mutational profile of exons 4 and 5 of GNAQ/GNA11 will facilitate improvement in our knowledge of these neoplasms, and may be useful for selection of patients for targeted therapeutic approaches. ...
Figure 1. clusterExplorer in action. In this screenshot the Amidohydrlase superfamily from the Structure-Function Linkage Database has been clustered using the MCL algorithm from clusterMaker. The clusters are depicted as attributes on the nodes and as groups in the Groups panel. clusterExplorer has been used to view the distribution of intercluster and intracluster edge weights. In addition, clusterExplorer was used to determine the nearest cluster to the node representing the protein gi5805954, which is a member of the unkown119 subgroup (the phosphotriesterase-homology proteins ...
Following Professor Aharonis collection in 1930, only infrequent sightings and captures were reported in the wild. Finally, to confirm the current existence of the wild golden hamster in northern Syria and southern Turkey, two expeditions were carried out during September 1997 and March 1999. The researchers found and mapped 30 burrows. None of the inhabited burrows contained more than one adult. The team caught six females and seven males. One female was pregnant and gave birth to six pups. All these 19 caught golden hamsters, together with three wild individuals from the University of Aleppo, were shipped to Germany to form a new breeding stock.[8] Observations of females in this wild population have revealed, contrary to laboratory populations, activity patterns are crepuscular rather than nocturnal, possibly to avoid nocturnal predators such as owls.[9] Owls, however, have also evolved to hunt at dusk and dawn, and even during the day on rare occasions, so the predator avoidance advantage ...
Previously we used mass spectrometry to show that the yeast G protein alpha subunit Gpa1 is ubiquitinated at Lys-165, located within a subdomain not present in other G alpha proteins (Marotti, L. A., Jr., Newitt, R., Wang, Y., Aebersold, R., and Dohlman, H. G. (2002) Biochemistry 41, 5067-5074). Here we describe the functional role of Gpa1 ubiquitination. We find that Gpa1 expression is elevated in mutants deficient in either proteasomal or vacuolar protease function. Vacuolar protease pep4 mutants accumulate monoubiquitinated Gpa1, and much of the protein is localized within the vacuolar compartment. In contrast, proteasome-defective rpt6/cim3 mutants accumulate polyubiquitinated Gpa1, and in this case the protein exhibits cytoplasmic localization. Cells that lack Ubp12 ubiquitin-processing protease activity accumulate both mono- and polyubiquitinated forms of Gpa1. In this case, Gpa1 accumulates in both the cytoplasm and vacuole. Finally, a Gpa1 mutant that lacks the ubiquitinated subdomain remains
Semantic Scholar extracted view of Spermine inhibition of basal and stimulated adenylate cyclase is mediated by the inhibitory GTP-binding protein (Gi). by Carlo Clô et al.