Multidrug-resistant gram-negative bacilli are emerging threats in the intensive care unit setting worldwide. Extended-spectrum β-lactamases, AmpC β-lactamases, and carbapenem-resistant Enterobacteriaceae are increasing at an alarming rate, leaving limited therapeutic options. In addition, multidrug resistance among Pseudomonas aeruginosa and Acinetobacter baumannii has widely disseminated and become a frequent cause of nosocomial infections within many intensive care units. Therefore, resistance is increasing to all currently available antibiotics, including cephalosporins, penicillins, aztreonam, carbapenems, fluoroquinolones, and aminoglycosides. Some multidrug-resistant gram-negative bacteria remain susceptible to only a few antibiotics such as tigecycline, fosfomycin, and polymyxins. The steady trend of increasing resistance coupled with the lack of novel antibiotics targeting resistant gram-negative bacilli has forced clinicians to increasingly apply more aggressive dosing strategies, ...
Gram-negative bacterial infection refers to a disease caused by gram-negative bacteria. One example is E. coli. It is important to recognize that this class is defined morphologically (by the presence of a bacterial outer membrane), and not histologically (by a pink appearance when stained), though the two usually coincide. One reason for this division is that the outer membrane is of major clinical significance: it can play a role in the reduced effectiveness of certain antibiotics, and it is the source of endotoxin. The gram status of some organisms is complex or disputed: Mycoplasma are sometimes considered gram-negative, but because of its lack of a cell wall and unusual membrane composition, it is sometimes considered separately from other gram-negative bacteria. Gardnerella is often considered gram-negative, but it is classified in MeSH as both gram-positive and gram-negative. It has some traits of gram-positive bacteria, but has a gram-negative appearance. It has been described as a ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
BioAssay record AID 558745 submitted by ChEMBL: Clearance of formed compound in patient with gram-negative bacterial infection at 250 mg/kg, iv.
The research report offers insights into both existing and therapeutics under development for the treatment of gram-negative bacterial infection.
Papers and discussions from a meeting held in Vienna, September 1973. Most of the papers will be of interest mainly to investigators of the nature and pathogenetic mechanisms of endotoxin. The seventh and eighth sections include, however, papers on important clinical problems precipitated by Gram-negative bacterial endotoxemia: coagulation disorders, shock, and pulmonary effects. Detailed subject index. ...
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Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Free flashcards to help memorize facts about Gram Negative Bacilli. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
Garenoxacin mesylate [USAN] is a novel oral des-fluoro quinolone with potent antimicrobial activity against common respiratory pathogens, including resistant strains and Gram-positive and Gram-negative bacterial infections.
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Stenotrophomonas maltophilia infection
What does this mean and reasons for caution?. There were several important observations drawn from this study. The first is that children with CF were found to be at increased risk of acquiring S. maltophilia infection, contrary to previous beliefs that this bacterium was more of a problem in older patients with CF and end stage lung disease. In addition, there has previously been a reluctance to treat patients with CF with oral antibiotics due to the risk of selecting out multi-drug resistant pathogens such as S. maltophilia. However, this study demonstrated that antibiotic therapy may actually be protective against S. maltophilia by slowing lung function decline. ...
The expression of the Stenotrophomonas maltophilia multidrug resistance (MDR) pump SmeDEF is transcriptionally regulated by SmeT (12), a local repressor encoded by the smeT gene, which is located upstream of smeD and which is divergently transcribed. SmeT binds to the intergenic smeT-smeD region, where the promoters of smeT and smeD are located. It has previously been found that a mutation in smeT is responsible for smeDEF overproduction in MDR strain S. maltophilia D457R (1, 12). However, nothing is known about the molecular basis of smeDEF overproduction in clinical S. maltophilia isolates. For that goal, the intergenic smeT-smeD region, which contains both the smeT and smeD promoters, as well as the smeT gene, were cloned from a collection of clinical S. maltophilia strains, 33% of which were SmeDEF overproducers (2), by PCR and sequenced as described previously (12). The strains used in this work are listed in Table 1. The intergenic region and the smeT gene were highly polymorphic (Fig. 1). ...
Roseomonas gilardii is a species of Gram negative, strictly aerobic, coccobacilli-shaped, pink-pigmented bacterium. It is the type species of the genus Roseomonas. The new species was among the first Roseomonas species proposed in 1993, and is named for "Gerald L. Gilardi for his many contributions to bacteriology and, specifically, for his contributions in the area of glucose-nonfermenting gram-negative rods." R. gilardii is pathogenic for humans, causing bacteremia and other infections. There are two subspecies of R. gilardii: R. g. subsp. gilardii and R. g. subsp. rosea. Rihs JD, Brenner DJ, Weaver RE, Steigerwalt AG, Hollis DG, Yu VL. Roseomonas, a new genus associated with bacteremia and other human infections. Journal of clinical microbiology. 1993 Dec 1;31(12):3275-83. Sanchez-Porro C, Gallego V, Busse HJ, Kämpfer P, Ventosa A. Transfer of Teichococcus ludipueritiae and Muricoccus roseus to the genus Roseomonas, as Roseomonas ludipueritiae comb. nov. and Roseomonas rosea comb. nov., ...
Multidrug-resistant Gram negative bacilli (MDR-GNB) are increasingly problematic in healthcare settings, primarily because of the paucity of effective antimicrobial agents that are available to treat infections with these organisms. Our MDR-GNB transmission prevention program includes hand hygiene promotion, antimicrobial stewardship, isolation precautions, environmental cleaning and disinfection, and programs to promote, monitor and sustain evidence-based best practices for Multidrug-Resistant Organism (MDRO) prevention. Tools and Resources. ...
Introduction: The present study was undertaken to determine the prevalence of non-fermenting gram negative bacilli and antibiogram of Pseudomonas aeruginosa and Acinetobacter baumannii. Materials and Methods: Conventional bacteriological methods were used for identification non fermenting gram negative bacilli and susceptibility testing was performed with the help of the Kirby-Bauer disc diffusion method. Results: A total 195 non fermenting gram negative bacilli were isolated during the study period. Pseudomonas aeruginosa and Acinetobacter baumannii isolates represent 89.23% of all isolated bacteria. Therefore, antibiotic resistance rates were performed specifically against these two bacteria. P. aerurginosa showed good sensitivity to imipenem(94.29%) followed by amikacin(86.67%) and piperacillin/tazobactum(68.57%). A. baumannii showed good sensitivity to imipenem(82.61%) followed by amikacin(76.81%). Conclusion: P. aeruginosa and A. baumannii were the most common NFGNB isolated in our study. ...
Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Dr. Yau has focused her research on the epidemiology, diagnosis and management of multi-drug resistant bacterial pahogens in cystic fibrosis (CF). Her research involve examining the epidemiology and clinical significance of Stenotrophomonas maltophilia infections in pediatric and adult CF patients, as well as determining the most effect antimicrobial combinations for the treatment of this infection in CF. She was the co-principal investigator on a multi-center randomnized controlled trial evaluating the utility of biofilm susceptibility assay in choosing more effective antibiotics to treat CF patients with chronic Pseudomonas aeruginosa pulmonary infection. She is also investigating the use of novel antimicrobial agents/modalities in the treatment of CF patients with multi-drug resistant Gram negative bacterial pulmonary infections. In addition, Dr. Yau is involved in a national multicentre study to determine the role of transmissible, clonal P. aeruginosa in the Canadian CF patient population ...
Background: The Verigene® Gram-Negative Blood Culture Test (BC-GN) detects 4 Gram-negative genera, 4 species, and 6 resistance genes within 2 hours of blood culture positivity, shortening the time from Gram stain to pathogen and resistance gene identification. The purpose of this study was to determine the impact of BC-GN testing paired with an antimicrobial stewardship intervention on antimicrobial and clinical outcomes.. Methods: This retrospective pre-post study compared patients admitted with a blood culture positive for a Gram-negative organism detectable by the BC-GN before (January 1, 2015 - July 1, 2015) and after (July 15, 2015 - January 15, 2016) this microarray test was implemented. The primary objective was to compare time from Gram stain to antimicrobial switch pre and post implementation. Secondary objectives included time from Gram stain to active treatment, in-hospital mortality, and hospital length of stay.. Results: 877 patients with Gram-negative bacteremia were included, 456 ...
An improvement resource to help health and social care economies reduce the number of Gram-negative bloodstream infections (BSIs) with an initial focus on Escherichia coli (E.coli).
Background: Gram-negative bacterial bloodstream isolates (GNBSIs) resistant to all available high-efficacy/low-toxicity (HELT) antibiotics (quinolones, penicillins, cephalosporins, carbapenems) exhibit difficult to treat resistance (DTR), which limits options for empiric and targeted therapy. The wrong empiric antibiotic may be selected even when GNBSIs remain susceptible to 1 or 2 HELT agents. Analyzing DTR trends allows assessment of the potential burden of inappropriate therapy and impact of antimicrobial resistance control interventions. Methods: Inpatient encounters (2009-2013) with ≥ 1 positive GNBSI (E. coli, Enterobacter spp., Klebsiella spp., P. aeruginosa or A. baumannii) were analyzed using PremierTM Database linked patient data from 180 US hospitals. Laboratory-reported categorical susceptibility breakpoints were used to categorize GNBSIs into respective DTR strata (non-DTR, DTR-2, DTR-1 and full DTR, denoting ,2, 2, 1 and 0 active HELT antibiotic classes, respectively). Annual ...
Follow-up blood cultures may have little utility in the management of Gram-negative bacilli bacteremia, according to data from a recent study.
402 patients enrolled. No significant difference in mortality (about 18% in both groups). No significant difference in rate of pneumonia recurrence (27%) and mean time to recurrence.. No signal with multivariate analysis, except: infections with non-lactose-fermenting Gram negative bacilli had more recurrence (i.e. same organism regrew) in the short-course group (40.6% vs 25.4%; 15.2% absolute hazard, 37.4% relative hazard).. No effects on secondary outcomes including organ dysfunction, vent-free days, ICU stay, etc, including in the subset of patients with NLFGNB infection. No difference in any outcome for MRSA pneumonias.. Significant reduction in antibiotic days, and MDR pathogens developed significantly less often in short-course group (42.1% vs 62.3%, p=.04). ...
Temocillin. Molecular model of the drug temocillin (C16.H18.N2.O7.S2), a beta-lactamase-resistant penicillin used to treat multiresistant Gram-negative bacterial infections. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue), oxygen (red) and sulphur (yellow). Illustration. - Stock Image F017/0687
Emerging evidences suggest systemic inflammation and postoperative infections lead to cancer recurrence (7-10). The mechanisms by which postoperative gram-negative bacterial infections promote cancer recurrence are poorly understood. Although LPS-induced systemic inflammation can increase cancer cell recruitment to the hepatic sinusoids (12) and liver metastasis in vivo (29), knowledge on the direct impact of LPS on the metastatic potentials of cancer cells in vivo is very limited. In this study, we have documented an increase in adhesion to endothelial cells and various ECM substrates in vitro and an enhancement in hepatic recruitment and liver metastasis in vivo by human colorectal cancer cells through LPS-induced TLR4 signaling.. Although LPS may alter proliferation and apoptosis in cancer cells (30, 31), and potentially explain the increased metastasis with LPS incubation of cancer cells, we did not show any proliferative or apoptotic changes in vitro after 4 hours of LPS treatment. This may ...
This topic has 2 study abstracts on Achillea fragrantissima indicating that it may have therapeutic value in the treatment of Polio, Candida Infection, and Gram-Negative Bacterial Infections
To Whom It May Concern "Lick of death: Capnocytophaga canimorsus is an important cause of sepsis in the elderly"1 describes an excellent outcome thanks to an elegant diagnostic work up and excellent treatment. However, I believe the headline "Lick of death" is unnecessarily fear-mongering and unwarranted (the patient, after all, did not die). Additionally, while the authors should be congratulated for educating practitioners about C. canimorsus, I feel there is scope for discussion with veterinarians to reduce further risk to this and other patients. The authors conclude that the source of the patients infection was the owners own dog, via a lick, on the grounds that Capnocytophaga canimorsus was isolated from that patient, that it is a zoonotic organism and that the patient admitted to being licked by the dog. My understanding is that this conclusion is based on findings that C canimorsus colonises the mouths of dogs and cats. This seems reasonable though for the sake of completeness and ...
We reviewed clinical and epidemiologic features of 56 human Capnocytophaga canimorsus isolates submitted during a 32-year period to California's Microbial Diseases Laboratory for identification. An increasing number of isolates identified as C. canimorsus have been submitted since 1990. Many laboratories still have difficulty correctly identifying this species.
We reviewed clinical and epidemiologic features of 56 human Capnocytophaga canimorsus isolates submitted during a 32-year period to California's Microbial Diseases Laboratory for identification. An increasing number of isolates identified as C. canimorsus have been submitted since 1990. Many laboratories still have difficulty correctly identifying this species.
Antibiotic treatment following a dog bite in an immunocompromized patient in order to prevent Capnocytophaga canimorsus infection: a case report. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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TY - JOUR. T1 - Proteomic analysis of 17β-estradiol degradation by Stenotrophomonas maltophilia. AU - Li, Zhongtian. AU - Nandakumar, Renu. AU - Madayiputhiya, Nandakumar. AU - Li, Xu. PY - 2012/6/5. Y1 - 2012/6/5. N2 - Microbial degradation plays a critical role in determining the environmental fate of steroid hormones, such as 17β-estradiol (E2). The molecular mechanisms governing the microbial transformation of E2 and its primary degradation intermediate, estrone (E1), are largely unknown. The objective of this study was to identify metabolism pathways that might be involved in microbial estrogen degradation. To achieve the objective, Stenotrophomonas maltophilia strain ZL1 was used as a model estrogen degrading bacterium and its protein expression level during E2/E1 degradation was studied using quantitative proteomics. During an E2 degradation experiment, strain ZL1 first converted E2 to E1 stoichiometrically. At 16 h E1 reached its peak concentration, and microbial growth started. At the ...
Stenotrophomonas maltophilia 菌血症で悩むStenotrophomonas maltophilia なお、SM菌血症と略すらしいです。感染症学雑誌 第87巻 第 5 号http://journal.kansensho.or.jp/Disp?pdf=0870050596.pdf先日、私も久々に…
Emergence of Stenotrophomonas maltophilia as a nosocomial pathogen is becoming increasingly apparent. Pleiotropic resistance characterizes S. maltophilia. Furthermore, a slow growth rate and an increased mutation rate generate discordance between in vitro susceptibility testing and clinical outcome. Despite original susceptibility, drug-resistant strains of S. maltophilia are often recovered from patients receiving beta-lactams, quinolones, or aminoglycosides. Given the disparity among various in vitro susceptibility methods, this study incorporated a unique pharmacodynamic model to more accurately characterize the bacterial time-kill curves and mutation rates of four clinical isolates of S. maltophilia following exposure to simulated multidose regimens of ceftazidime, ciprofloxacin, gentamicin, and ticarcillin-clavulanate. Time-kill data demonstrated regrowth of S. maltophilia with all four agents. With the exception of ticarcillin-clavulanate, viable bacterial counts at the end of 24 h ...
Aeromonas sobria is a mesophilic motile aeromonad currently depicted as an opportunistic pathogen, despite increasing evidence of mutualistic interactions in salmonid fish. However, the determinants of its host-microbe associations, either mutualistic or pathogenic, remain less understood than for other aeromonad species. On one side, there is an over-representation of pathogenic interactions in the A. sobria literature, of which only three articles to date report mutualistic interactions; on the other side, genomic characterization of this species is still fairly incomplete as only two draft genomes were published prior to the present work. Consequently, no study specifically investigated the biodiversity of A. sobria. In fact, the investigation of A. sobria as a species complex may have been clouded by: (i) confusion with A. veronii biovar sobria because of their similar biochemical profiles, and (ii) the intrinsic low resolution of previous studies based on 16S rRNA gene sequences and multilocus
INTRODUCTION Stenotrophomonas maltophilia is an important cause of hospital acquired infection particularly among severely debilitated and immunosuppressed patients. CASE PRESENTATION We report a case of S. maltophilia meningitis in a preterm baby boy after a neurosurgical procedure, successfully treated with trimethoprim-sulfamethoxazole and ciprofloxacin. CONCLUSION This organism should be considered as a potential cause of meningitis and trimethoprim-sulfamethoxazole and ciprofloxacin are a combination that is successful and safe for treating preterm infants.
There were 1632 admissions with 45 nosocomial Gram-negative bacteremias in 44 patients. Infection rates of 28.2/1000 admissions and 12.1/10 000 patient-days remained stable over 5 years. The mean patient age was 55.3 years (range 17-86 years); 27.3% of patients were female, and 72.8% were male. The majority (95.6%) of bloodstream infections were monomicrobial, with only one episode of polymicrobial bacteremia. Common admitting diagnoses included respiratory failure, solid organ transplant, post-surgery, and multi-trauma. Seven bacterial species were identified; Pseudomonas aeruginosa and Enterobacter spp. were most common. Sources of bacteremia included pneumonia (48.9%), followed by central venous catheterization (22.2%). The mean time from admission to hospital to development of bacteremia was 32.9 days (95% confidence interval [CI] 0-100.9), and time from admission to the ICU was slightly less at 26.0 days (95% CI 0-90.1). Antimicrobial susceptibilities were highest for imipenem, gentamicin, ...
Aeromonas hydrophila. Coloured transmission electron micrograph of thin-sectioned cells of Aeromonas hydrophila bacteria. It is a Gram- negative, rod-shaped bacillus. Aeromonas hydrophila is associated with septicaemia, pneumonia and gastroenteritis in humans. In particular it causes opportunistic infections in patients with lowered immunity, such as in cancer and liver disease. Aeromonas hydrophila has been isolated from urine, sputum, faeces and bile. It is resistant to many types of antibiotic including penicillin, but can be controlled with tetracyclins and gentamicin. Magnification: x28,800 at 6x4.5cm size. - Stock Image B220/0809
Rice, L.B. (2007) Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria. Cleveland Clinic Journal of Medicine, 74, S12-S20.
Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by elevated pulmonary artery pressure and pulmonary vascular resistance. Continuous infusion of a prostanoid, which acts as a vasodilator and anti-proliferative agent, is indicated in the treatment of patients with severe PAH. Two prostanoids are approved for intravenous (IV) use in the United States: epoprostenol (epoprostenol sodium [brand name Flolan®], Gilead, Foster City, California) and treprostinil (treprostinil sodium [brand name Remodulin®], United Therapeutics, Silver Spring, Maryland) (1). These drugs are administered to PAH patients at hundreds of treatment centers in the United States. In September 2006, CDC received a report from a PAH specialist of a suspected increase in the number of gram-negative bloodstream infections (BSIs) among PAH patients treated with IV treprostinil. CDC conducted a retrospective investigation with the assistance of several state health departments and the cooperation of ...
Background: Dog bites are the most common animal bite injuries occurring in the United States. Estimated infection rates range between 15% and 20%. Polymicrobial infections are most common. Capnocytophaga canimorsus (C. canimorsus) is a Gram-negative rod strongly associated with dog bites, and is known to cause life-threatening infection in humans. A 42-year-old woman with septic shock: An unexpected source. Richard Sacks and Kim ...
Ochrobactrum anthropi is a common soil alphaproteobacterium (7) that can interact with or colonize many eukaryotic organisms, leading to different outcomes, such as disease or even growth of some plants (references 4 and 13 and references therein). O. anthropi, a close relative of brucellae, has not garnered much attention (5, 8) but is becoming increasingly recognized as a potentially problematic opportunistic and nosocomial pathogen (13). A rising number of reported cases includes some potentially life-threatening infections, such as endocarditis (6, 9, 14). These reports, together with the organisms intrinsic multiresistance to antibiotics (13), could lead to a situation resembling that of an Acinetobacter sp., whose importance as a highly problematic nosocomial pathogen skyrocketed in the past few years (12). The increasing relevance of O. anthropi to human health, together with its phylogenetic proximity to the highly pathogenic brucellae (a USDA Select Agent), prompted us to determine the ...
All bacteraemic cases, from August 2006 to September 2007 were identified by reviewing all positive blood culture results from the microbiology department of our hospital. One thousand three hundred and sixty six cases were detected in 1336 patients. The rate of true bacteremia which was 13.1 and 10.7% of cultures were contaminated. Of the 1366 episodes of bloodstream infection, 55.3% were community-acquired and 44.7% were health-care associated. Gram-positive bacteria prevailed (58.5%), followed by gram negative bacilli (38.5%). Polymicrobial bacteremia was detected in 2.2% of cases. Coagulase-negative staphylococci (CoNS) were the leading cause (550/1366 = 40.3%), whilst enterococci,Staphylococcus aureus and Streptococci represented 8, 6.4 and 3.8% respectively. Pseudomonas aeruginosa was the commonest gram-negative isolate (155/1366 = 11.3%), followed by Escherichia coli (8.2%) and Acinetobactersp. (7.3%). Fungi were isolated in
Aeromonas hydrophila ATCC ® 7966D-5™ Designation: Genomic DNA from Aeromonas hydrophila TypeStrain=True Application: Water testing
Akbar, Sirwan, Rout, Simon and Humphreys, Paul (2015) Draft Genome Sequence of the Biofilm-Forming Stenotrophomonas maltophilia Strain 53. Genome Announcements, 3 (2). e00312-15. ISSN 2169-8287 Alhudhud, M, Humphreys, Paul and Laws, Andrew P. (2014) Development of A Growth Medium Suitable for Exopolysaccharide Production and Structural Characterisation by Bifidobacteria animalis ssp. lactis. Journal of Microbiological Methods, 100. pp. 93-98. ISSN 0167-7012 Bogdarina, Irina, Murphy, Helena C., Burns, Shamus P. and Clark, Adrian J.L. (2004) Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming. Life Science, 74 (11). pp. 1407-1415. ISSN 0024-3205 Burns, Shamus P., Murphy, Helena C., Iles, Richard A. and Cohen, Robert D. (2001) Lactate supply as a determinant of the distribution of intracellular pH within the hepatic lobule. Biochemical Journal, 3. pp. 569-571. ISSN 0264-6021 Charles, C.J., Rout, S.P., Garratt, E.J., Patel, K., Laws, A.P. and ...
Certain strains of Aeromonas hydrophila are oxidase negative when grown on gram-negative selective and differential media. Of 100 strains of A. hydrophila examined, 8 were found to possess this characteristic. Information is provided on how to detect these common variants of A. hydrophila.
1N4O: Role of the disulfide bridge Cys69-Cys238 in class A b-lactamases : a structural and biochemical investigation on the b-lactamase L2 from Stenotrophomonas maltophilia
β -lactamase enzymes inactivate β -lactam antibiotics and render them ineffective for the treatment of clinically-important Gram-negative bacterial infections. Now, two new kits from Streck Inc., available in the UK from
Aeromonas hydrophila ATCC ® 7966™ Designation: TypeStrain=True Application: Quality control strain Reference material Testing Water testing
1EI5: Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the penicillin-recognizing enzyme family.
SWISS-MODEL Repository entry for A0KNI2 (ACSA_AERHH), Acetyl-coenzyme A synthetase. Aeromonas hydrophila subsp hydrophila (strain ATCC 7966 / DSM 30187 / JCM1027 / KCTC 2358 / NCIMB 9240)
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Infectious Disease News | BOSTON - The pipeline for new therapies to treat drug-resistant gram-negative bacilli is small, but measurable progress is being made, according to Helen Boucher, MD, who presented results on the progress of IDSAs 10 x 20 initiative. She and colleagues identified nine intravenous compounds in development to treat these resistant bacteria. Since a previous survey was conducted in
Rattanaumpawan, P., Ussavasodhi, P., Kiratisin, P. and Aswapokee, N. (2013) Epidemiology of Bacteremia Caused by Uncommon Non-Fermentative Gram-Negative Bacteria. BMC Infectious Diseases, 13, 167-175.
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There are many different types of bacterial infection treatments, which vary depending on the type of bacteria that is causing...
Looking for online definition of Capnocytophaga sputigena in the Medical Dictionary? Capnocytophaga sputigena explanation free. What is Capnocytophaga sputigena? Meaning of Capnocytophaga sputigena medical term. What does Capnocytophaga sputigena mean?
A systematic evaluation of the attributable mortality of Stenotrophomonas maltophilia bacteremia was undertaken in a matched, retrospective, case-control study. We determined the attributable mortality rate (26.7%) and mortality risk ratio (an 8-fold increase) of S. maltophilia bacteremia. The attributable mortality rate for S. maltophilia bacteremia is similar to the attributable mortality rate for other nosocomial bloodstream infections.. ...
TY - JOUR. T1 - Levofloxacin Efflux and smeD in Clinical Isolates of Stenotrophomonas maltophilia. AU - Chong, So Young. AU - Lee, Kyungwon. AU - Chung, Hae Sun. AU - Hong, Seong Geun. AU - Suh, Younghee. AU - Chong, Yunsop. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Trimethoprim-sulfamethoxazole is the first-line antimicrobial combination for Stenotrophomonas maltophilia infections. However, allergy or intolerance and increasing resistance limit the use of trimethoprim-sulfamethoxazole. Quinolones can be used as an alternative therapeutic option, but resistance can emerge rapidly during therapy. We analyzed the contribution of SmeABC and SmeDEF efflux pumps to levofloxacin resistance in clinical isolates of S. maltophilia. Nonduplicate clinical isolates of S. maltophilia were collected in 2010 from 11 university hospitals (n = 102). Fifty-five levofloxacin nonsusceptible (minimum inhibitory concentration [MIC] ≥4 μg/ml) and 47 susceptible (MIC ≤2 μg/ml) isolates were tested for efflux pump ...
Why is this important?. Several cystic fibrosis centres worldwide have reported that Stenotrophomonas maltophilia has become more common. This is a multi-drug resistant, opportunistic bacterium that often causes hospital-acquired infections (e.g. pneumonia). Although, the clinical consequences and importance of S. maltophilia colonisation in people with CFsairways are still debated, it has been recently demonstrated that chronic S. maltophilia infection may increase the risk for pulmonary exacerbations. ...
Shared Genotypes of Achromobacter xylosoxidans Strains Isolated from Patients at a Cystic Fibrosis Rehabilitation Center: During a study examining transmission
Looking for online definition of Aeromonas hydrophila in the Medical Dictionary? Aeromonas hydrophila explanation free. What is Aeromonas hydrophila? Meaning of Aeromonas hydrophila medical term. What does Aeromonas hydrophila mean?
Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species (ROS) due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter bethesdensis is an emerging Gram-negative pathogen in CGD that resists killing by PMN of CGD patients (CGD PMN) and inhibits PMN apoptosis through unknown mechanisms. Microarray analysis was used to study mRNA expression in PMN from healthy subjects (normal PMN) and CGD PMN during incubation with G. bethesdensis and, simultaneously, in G. bethesdensis with normal and CGD PMN. We detected upregulation of antiapoptotic genes (e.g., XIAP and GADD45B) and downregulation of proapoptotic genes (e.g., CASP8 and APAF1) in infected PMN. Transcript and protein levels of inflammation- and immunity-related genes were also altered. Upon interaction with PMN, G. bethesdensis altered the expression of ROS ...
Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
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INTRODUCTION The genus Arcobacter belongs to the family Campylobacteraceae, class Proteobacteria, subclass Gracillicutes and comprises four species Arcobacter butzleri, A. cryaerophilus, A. nitrofigilis and A. skirrowii, formerly known as aerotolerant Campylobacter-like organisms (Vandamme, 2000).. The first isolates were obtained by Ellis et al. (1977) from aborted bovine fetuses. Further studies related these microorganisms with mastitis and abortion in the bovine, ovine, equine and porcine species (Logan et al., 1982; Vandamme 2000).. Of the four described species, only A. cryaerophilus and A. butzleri have been isolated from human beings, and are associated with bacteremia and diarrhea. A. butzleri has been isolated from patients with endocarditis, peritonitis and appendicitis. Both are considered as emerging foodborne pathogens that could be acquired by consuming mussels, poultry meat, offal and contaminated water (Jacob et al., 1998, Mansfield and Forsythe, 2000). Some studies have been ...
2] https://www.ncbi.nlm.nih.gov/pubmed/?term=LONGITUDINAL%20STUDY%20OF%20STENOTROPHOMONAS%20MALTOPHILIA%20ANTIBODY%20LEVELS%20AND%20OUTCOMES%20IN%20CYSTIC%20FIBROSIS% ...
The present study describes the S. maltophilia-induced PE of 14 patients who were infected within a period of 4 months at a single hospital because of a contaminated drainage cassette. Described in this study are the clinical characteristics, the effects of antibiotics and PPV, and the final visual acuities after treatments for S. maltophilia as the potential source of the infections.. In the culture-positive group, the median time from surgery to infection was 9.5 days (1-17 days). This time period was comparable with patients in a previous report [13], whose symptoms began between postoperative days 1 and 19. However, in another report [14], endophthalmitis by the same bacteria was fully developed in 26 patients within 2 days after surgery. Based upon the Endophthalmitis Vitrectomy Study (EVS), more virulent microorganisms (e.g., Gram-negative bacteria) were more likely to be diagnosed within 2 days of cataract surgery. However, in our study, as a Gram-negative bacterium, S. maltophilia was ...
The asplenic state is a health risk increasingly being recognised by health professionals all over the world. Infection in patients with an absent or dysfunctional spleen remains largely preventable. Many measures have been proposed to reduce the risk of sepsis after splenectomy, which include chemoprophylaxis, immunoprophylaxis, and patient/clinician education.6. Other than the known susceptibility of splenectomised individuals to encapsulated bacteria (Streptococcus pneumoniae, N meningitides, and H influenziae),7 there is evidence to suggest that other organisms, such as Gram negative bacteria and Capnocytophaga canimorsus,2 in addition to intraerythrocytic parasites, such as babesia and plasmodium, can cause infections and carry considerable morbidity.8. The pneumococcal vaccine, first introduced in the 1970s, presently includes 23 serotypes responsible for approximately 88% of pneumococcal infections. However, the most virulent pneumococcal serotypes tend to be the least immunogenic, and ...
The present study through transversal analysis reveals the profile of patients infection in the ICUs of a Tertiary care hospital. It aims at categorizing patients with a focus on the prevalence rates of infection, sites and types of infection, most prevalent bacteria and its antimicrobial resistance patterns, as well as identifying the risk factors for ICU acquired infection. One of the 50 patients admitted to ICU showed bacteremia due to Pseudomonas aeruginosa. This isolate might not necessarily have represented the cause of infection nevertheless regarding the isolates reported. The predominance of Gram negative bacilli P. aeruginosa was identified. Previous report, showed the predominance of Gram positive cocci Staphylococcus aureus, and Gram negative organisms P. aeruginosa.. [PDF] , ...
There is a type of acne caused by gram negative bacteria. This is very unusual. All other acne are caused by gram positive bacteria. Gram negative bacteria generally cause infections of organs inside the body and very rarely on the skin. Any infection caused by a gram negative bacteria is considered serious.
There is a type of acne caused by gram negative bacteria. This is very unusual. All other acne are caused by gram positive bacteria. Gram negative bacteria generally cause infections of organs inside the body and very rarely on the skin. Any infection caused by a gram negative bacteria is considered serious.
Imipenem is a carbapenem antibacterial agent with a broad spectrum of activity against Gram-negative and Gram-positive bacteria. This agent is often used as the last line of therapy for highly resistant Gram negative bacilli nosocomial infections. In common with other beta-lactamase inhibitor, the main pharmacokinetic/pharmacodynamic (PK/PD) index that correlates with the therapeutic efficacy is the time that concentrations in the tissue and serum are above the MIC and administration by continuous infusion is the preferred mode of administration to maximize this parameter.. However, in tropical countries, the stability of carbapenem antibiotics is an important consideration when considering continuous infusion. Therefore, prolonged infusion may be a useful mode of administration to maximize bactericidal activity. This study will demonstrate the stability of imipenem in clinical use at room temperature in tropical countries. ...
Αmong 145 patients with gram-negative COB, 83 (57.2%) had HCAB and 62 (42.8%) had CAB. The frequency of malignant tumors, renal insufficiency and dementia was higher in patients with HCAB than with CAB. In both groups Escherichia coli was the mostcommon causative agent but the prevalence of Klebsiella pneumoniae in HCAB was significantly higher than CAB (19.3% vs. 4.8%). Patients with HCAB had higher Charlson score and higher Pitt bacteremia score, less frequent administration of appropriate empirical antibiotic treatment and higher probability of death than patients with CAB.. The antimicrobial resistance in HCAB και CAB patients respectively, was found 27/83 (32.5%) vs. 4/62 (6.5%) (P,.001) to third-generation cephalosporins (3GC), 22/83 (26.5%) vs. 7/62 (11.3%) (P=.021) to aminoglycosides, 29/83 (34.9%) vs. 9/62 (14.5%) (P=.005) to quinolones. Bacteria that produced ESBL were 16/76 (21.1%) vs. 2/59 (3.4%) (P=.003), and carbapenem-resistant were 10/83 (12.0%) vs. 2/62 (3.2%) (P=.056) in ...
42 out of 52112 patients (0.00081) who underwent cataract surgery developed endophthalmitis. Male: female ratio was 26:16. Mean time interval between surgery and presentation was 14.48±14.61 days. There was no statistical significance based on surgeon experience (p 0.424) or type of procedure. 76.2% had hypopyon and 23.8% had fibrin reaction (p 0.007). Eleven (26.2%) eyes needed vitrectomy, two eyes needed sclerocorneal patch graft and one underwent evisceration. Culture was positive 0.07% of eyes. Smear was positive for Gram negative bacilli in 16.7%, Gram positive cocci in 4.8% and fungus in 4.8% of cases. PCR was positive for eubacterial genome in 57.2%, pan fungal genome in 2.4% and both in 7.1%. In vitreous aspirate PCR was positive for eubacterial genome & P.acne in 3/11 (27.27%), eubacterial genome & panfungal genome in 1/11(0.09) for eubacterial genome alone in 1/11(0.09). Final mean BCVA improved from 6/120 to 6/18(P= ...
God is too wise to be mistaken. God is too good to be unkind. So when you dont understand, when you dont see His plan, when you cant trace His hand, trust His heart." Last May 9, 2017 Papa had his first hospital admission due to Stroke, and he stayed there until May 21. He had no paralysis, only myopathy. During the days that he was in the house, he slowly recovered. He religiously had his physical therapy and did great with his recovery. He got readmitted June 9 due to Pneumonia, Septic Arthritis, Amoebiasis, and Abdominal Bleeding. He was supposed to be discharged on June 29 just in time for his last antibiotic treatment. However, on June 24, he suffered from a Heart Attack so he was placed in ICU. He was cleared for discharge on July 6, with NGT feeding. This was his longest stay at the hospital. On July 31, he had his follow up checkup but while at the clinic, he vomited blood. We did not want to be complacent with his condition so he got admitted for the third time. Within his admission, ...
A simulated CSF smear collected from a 17 year old male patient with hydrocephalus and an infected CSF shunt was sent to category A, B, C, and C1 laboratories for Gram staining.. Participants were expected to report the presence of gram negative bacilli, gram positive bacilli, and neutrophils.. ...
UK/London: The Condiment Company, a West Marden, Chichester, West Sussex establishment, recalls certain batch/lots of Hunter & Gather Avocado Oil Mayonnaise due to suspected Salmonella contamination and consequential risk of Gram-negative bacterial infection, severe illness and/or possible life-changing complications, all serious health hazards. As well, the Mayonnaise may contain mould, another potential source of infection,…
Serological Studies of Aeromonas Hydrophila in Bangladesh 2155 9546 1000351 - Free download as PDF File (.pdf), Text File (.txt) or read online for free. das
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
SWISS-MODEL Repository entry for A0KIP8 (SPEA_AERHH), Biosynthetic arginine decarboxylase. Aeromonas hydrophila subsp hydrophila (strain ATCC 7966 / DSM 30187 / JCM1027 / KCTC 2358 / NCIMB 9240)
Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections.. Colistin is used as salvage therapy against multidrug resistant Gram-negative infections. In this work, a whole-body physiologically based pharmacokinetic model (WBPBPK) was developed to characterize the pharmacokinetics (PK) of colistin and its prodrug colistin methanesulfonate (CMS) in animal and human. The scalability of the model from animal to human was assessed with satisfactory predictive performance for CMS and demonstrating the need for a mechanistic understanding of colistin elimination.. The WBPBPK model was applied to ...
OBJECTIVE Candida auris (CA) is an emerging multidrug-resistant pathogen associated with increased mortality. The environment may play a role, but transmission dynamics remain poorly understood. We sought to limit environmental and patient CA contamination following a sustained unsuspected exposure. DESIGN Quasi-experimental observation. SETTING A 528-bed teaching hospital. PATIENTS The index case patient and 17 collocated ward mates. INTERVENTION Immediately after confirmation of CA in the bloodstream and urine of a patient admitted 6 days previously, active surveillance, enhanced transmission-based precautions, environmental cleaning with peracetic acid-hydrogen peroxide and ultraviolet light, and patient relocation were undertaken ...
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Takahashi Eizo , Fujii Yoshio , Kobayashi Hidetomo , YAMANAKA Hiroyasu , BALAKRISH NAIR Gopinath , TAKEDA Yoshifumi , ARIMOTO Sakae , NEGISHI Tomoe , OKAMOTO Keinosuke Microbiology and immunology 54(10), 596-605, 2010-10-20 医中誌Web 参考文献30件 ...
Researchers from the University of California San Diego have identified a potential new target against Pseudomonas aeruginosa infections - which could be applied to help treat all gram-negative infections. It was found that by interfering with the Mla pathway in P. aeruginosa, the bacteria became more permeable, and more susceptible to immune components. P. aeruginosa, … Read more. ...
microbiology result UNKNOWN INSTRUCTIONS DAY 1: Today you will be given a broth tube containing two unknown microorganisms: a Gram-positive coccus and a Gram-negative rod.…
Chow, M.S., and M.A. Rouf. 1983. Isolation and partial characterization of two Aeromonas hydrophila bacteriophages. Appl. Environ. Microbiol. 45: 1670-1676. ...
In an attempt to catch up on what went wrong last week and why we are still trying to correct some of that, Im going to do a head to toe assessment of what some of Kendalls issues were and still are. Some of you may not understand this at all, and some of you…. ...
... is a kind of dermal condition in which the persons skin gets damaged or hurt by few harmful bacteria and can cause infections or serious diseases in a living body.
Bacterial infections are the most common cause of sepsis. If an infection cannot be prevented, rapid and effective treatment are vital to prevent sepsis.
Bacterial infections meet their match with Generic Macrobid, an antibiotic mediation that is made to fight off and stop the spreading of bacterial infections in the body. For effective relief of bl...
As part of the SENTRY Antimicrobial Surveillance Program, a total of 1078 Acinetobacter species and 842 Stenotrophomonas maltophilia isolates were collected between January 1997 and December 1999 from 5 geographic regions (Canada, the United States, Latin America, Europe, and the Asia-Pacific). The frequency of infections (by geographic region and body site), including those due to imipenem-resistant Acinetobacter species and trimethoprim-sulfamethoxazole (TMP-SMZ)-resistant S. maltophilia, was evaluated. The possibility of seasonal variations in bloodstream infections caused by Acinetobacter species was studied, as was the activity of several therapeutic antimicrobials against all strains. Acinetobacter species and S. maltophilia were most frequently associated with pulmonary infections, independent of the region evaluated. In contrast, patterns of antimicrobial resistance markedly varied among distinct geographic regions, especially for nosocomial isolates. Although the carbapenems were the ...
New publication on Attributable Mortality of Healthcare-Associated Infections Due to Multidrug-Resistant Gram-Negative Bacteria and Methicillin-Resistant Staphylococcus Aureus from Infection Control & Hospital Epidemiology Attributable Mortality of Healthcare-Associated Infections Due to Multidrug-Resistant Gram-Negative Bacteria and Methicillin-Resistant Staphylococcus Aureus
Infections due to Aeromonas hydrophila and Plesiomonas shigelloides in immuno-compromised hosts have been well documented, but the role of these organisms in causing gastrointestinal disease in healthy persons is controversial. Despite difficulties in characterizing the exotoxins produced by Aeromonas species, there is accumulating evidence that these bacteria are capable of causing usually mild, self-limited diarrheal disease in previously healthy adults. Some pediatric patients may have protracted dysenteric symptoms. P.
Stenotrophomonas maltophilia ATP-dependent Clp protease ATP-binding subunit ClpX (clpX) datasheet and description hight quality product and Backed by our Guarantee
Colonization by Alcaligenes xylosoxidans in children with cystic fibrosis: a retrospective clinical study conducted by means of molecular epidemiological investigation
TY - JOUR. T1 - Factors associated with severe sepsis or septic shock in patients with gram negative bacteraemia. T2 - An observational cohort study. AU - Maturu, Mohan V.Sumedha. AU - Kudru, Chandrashekar Udyavara. AU - Eshwara, Vandana Kalwaje. AU - Guddattu, Vasudeva. PY - 2018/12/1. Y1 - 2018/12/1. N2 - Introduction: Sepsis is a systemic, host response to infection that progresses from sepsis to severe sepsis to septic shock. Severe sepsis carries significant morbidity and mortality. In the presence of individual risk factors such as old age, diabetes mellitus, chronic liver and renal disease, the death rate remains high despite treatment with antimicrobial agents. Aim: To determine the factors associated with severe sepsis or septic shock and to identify the factors influencing the mortality among patients with gram-negative bacteraemia. Materials and Methods: In this observational cohort study, 219 patients with gram-negative bacteraemia were screened for the presence of sepsis, severe ...
Carbapenem-Resistant Gram- Negative Bacilli in Canadian Acute-Care Hospitals: Surveillance Report January 1, 2010 to December 31, 2012