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... and its derivatives are active against the HIV virus 15 and the herpes simplex virus type 2. [35] [Lin TS, Schinazi. Selective inhibition of human immunodeficiency virus type 1replication by the (-) but not the (+) enantiomer of gossypol. Antimicrob Agents Chemother. 1989 Dec;33(12):2149-51]. A trial evaluated the therapeutic efficacy of gossypol for the treatment of metastatic carcinoma of the endometrium or ovary, and as an antiviral and interferon inducer in patients with AIDS [36] [Wu D. An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. Drugs . 1989;38:333-341]. At low doses (30 mg/kg), the drug reduces 65% the tumor size and induces tumor mortality (8%) in nude-mice SW-13 adrenocortical carcinoma [24] [Wu, Y.W., Chik, C. L., Knazek, R. A., An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma, Cancer Res. 1989, 49, 3754 -3758.] . Furthermore, in ...
Cottonseed can be used for ruminant diets, but non-ruminants are too sensitive for the toxic substance gossypol, a nasty by-product of the cotton plant. Luckily, US researchers have developed a gossypol-free variety of cottonseed.otton production is one of the largest production crops around the world. The plant is used for fibre for the textile industry, but the by-product is the cottonseed. For every 1 kg of cotton fibre, the plant produces around 1.65 kg of seed. Cottonseed consists of 21% oil and relatively high-quality protein (23%). But the cotton plant also has another - less wanted - by-product: gossypol. This is a secondary metabolite and serves as a defence compound for the plant due do its bitter taste. Gossypol toxicity Cottonseeds are often used as a feed ingredient, due to its favourable protein content, but what about the gossypol content? Monogastric animals, such as pigs, birds, fish, and rodents, are more susceptible to gossypol toxicity than ruminants. Adult ruminant animals ...
This invention relates to compositions comprising co-crystals of (-)-gossypol with a C.sub.1-8 carboxylic acid or C.sub.1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (-)-gossypol with a C.sub.1-8 carboxylic acid or C.sub.1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
DON and small molecule Bcl-2 family antagonists treating glutamine addicted cell lines for Neuroblastomas and Ewing sarcomas (SJ-13-0026)
Indeed, gossypol, a toxic polyphenol derived from the cotton plant, was identified early on in the Foundations research as an effective sterilant. The question was, how to implement or integrate the toxic substance into crops. "Another long-term interest of the Foundation has been gossypol, a compound that has been shown to have an antifertility effect in men, By the end of 1985, the Foundation had made grants totaling approximately $1.6 million in an effort to support and stimulate scientific investigations on the safety and efficacy of gossypol." In the 1986 Rockefeller Foundation annual report, the organization admits funding research into the use of fertility-reducing compounds in relation to food for "widespread use": "Male contraceptive studies are focused on gossypol, a natural substance extracted from the cotton plant, and identified by Chinese researchers as having an anti-fertility effect on men. Before widespread use can be recommended, further investigation is needed to see if ...
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Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Expression of developmentally regulated endothelial cell locus 1 was induced by tumor-derived factors including VEGF. Indirect immunofluorescence showed that most bacteria were fully internalized when flashing occurred, suggesting that actin flashing does not represent phagocytosis. Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. Phenotyping of VIGS-mediated gene silencing in rice using a vector derived from a DNA virus.. Magnetic resonance imaging (MRI) revealed a well-circumscribed, brighter mass in the right masseter muscle with numerous rounded areas of signal hypointensity. Adjuvants play an important role in the formulation of effective and appropriate vaccines. Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner.. Some reasons for variation are organisational, but ...
Mimicking the BH3 domain to kill cancers is a strategy that is presently being explored in the development of Bcl2 inhibitors as anticancer drugs (40, 41). By binding to the hydrophobic cleft of Bcl2/Bcl-XL, the BH3 mimetics function as competitive inhibitors (18, 40). Three small-molecule Bcl2 inhibitors, including gossypol (AT-101), obatoclax (GX15-070), and ABT-263, are in clinical trials (phase I∼II; refs. 40, 41). Gossypol and obatoclax are BH3 mimetics that act as pan-Bcl2 inhibitors (12, 41). However, gossypol and obatoclax are not entirely dependent on Bax and Bak for apoptosis induction and toxicity to normal cells (40, 42). In contrast, the Bad BH3 mimetic ABT-737 was ineffective in inducing apoptosis in cells doubly deficient in Bax and Bak, indicating that its mechanism of action may be predominantly through the Bcl2 family (40, 43). ABT-737 selectively binds to Bcl2, Bcl-XL, and Bcl-W but not Mcl-1 and Bfl-1/A1 (18). However, ABT-737 resistance can be caused by expression of Mcl-1 ...
Plasmid LB1360 (Bcl-2 promoter with MHS4) from Dr. Linda Boxers lab contains the insert B-cell lymphoma/leukemia-2 and is published in Oncogene. 2007 Apr 19. 26(18):2635-41. This plasmid is available through Addgene.
A class of substituted 2-cycloalkylaminoalkylphenols, preferably D,L-6-(N-.alpha.-pipecolinomethyl)-5-hydroxyindane, enantiomers thereof and acid addition salts thereof have been found to exhibit oral antifertility activity in male aves and mammals. These compounds may therefore be utilized to induce temporary or non-reversible sterility in treated subjects.
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
Signaling by the ubiquitously expressed tumor necrosis factor receptor 1 (TNFR1) after ligand binding plays an essential role in determining whether cells exhibit survival or death. TNFR1 forms distinct signaling complexes that initiate gene expression programs downstream of the transcriptional regulators NFκB and AP-1 and promote different functional outcomes, such as inflammation, apoptosis, and necroptosis. Here, we investigated the ways in which TNFR1 was organized at the plasma membrane at the nanoscale level to elicit different signaling outcomes. We confirmed that TNFR1 forms preassembled clusters at the plasma membrane of adherent cells in the absence of ligand. After trimeric TNFα binding, TNFR1 clusters underwent a conformational change, which promoted lateral mobility, their association with the kinase MEKK1, and activation of the JNK/p38/NFκB pathway. These phenotypes required a minimum of two TNFR1-TNFα contact sites; fewer binding sites resulted in activation of NFκB but not ...
Chai, J., Shiozaki, E., Srinivasula, S. M., Wu, Q., Datta, P., Alnemri, E. S., Shi, Y., Dataa, P. (2001). Structural basis of caspases-7 inhibition by XIAP. Cell. 104:769-780 El-Deiry, W. S., Jin, Z. (2005). Overview of cell death signalling pathways. Cancer biology and therapy. 4(2):139-163 Fadeel, B., Orrenius, S. (2005). Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. Journal of internal medicine. 258:479-517 Fischer, U., Schulze-Osthoff, K. (2005). Apoptosis-based therapies and drug targets. Cell death and differentiation. 12:942-961 Gewies, A. (2003). Introduction to apoptosis. Aporeview. 1-26 Mazumder, S., Plesca, D., Almasan, A. (2005). Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods in molecular biology. 414:13-21 Ranger, A. M., Malynn, B. A., Korsmeyer, S. J. (2001). Mouse models of cell death. Nat genet. 28:113-118 Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S. W., ...
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
Whole cottonseed contains some free gossypol, which can be toxic to some livestock species. However, gossypol toxicity is usually not a concern with beef cattle except for young calves under four months of age and for breeding bulls. Gossypol is known to interfere with male fertility. Gossypol-induced infertility in bulls should not be of concern if recommended feeding levels are not exceeded. However, to err on the side of caution, do not feed whole cottonseed to bulls 60 to 90 days before the start of the breeding season or to young growing bulls to be sold for breeding. For more information, refer to edis.ifas.ufl.edu/AN130. ...
TY - JOUR. T1 - A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma. AU - Xie, Hao. AU - Yin, Jun. AU - Shah, Manisha H.. AU - Menefee, Michael E.. AU - Bible, Keith C.. AU - Reidy-Lagunes, Diane. AU - Kane, Madeleine A.. AU - Quinn, David I.. AU - Gandara, David R.. AU - Erlichman, Charles. AU - Adjei, Alex. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic. AT-101 is a more potent inhibitor of B cell lymphoma 2 family apoptosis-related proteins than its racemic form, gossypol, which showed preliminary clinical activity in ACC. We thus evaluated the efficacy of AT-101 in patients with advanced ACC. Methods Patients with histologically confirmed metastatic, recurrent, or primarily unresectable ACC were treated with AT-101 (20 mg/day orally, 21 days out of 28-day cycles) ...
Interpretive Summary: Technical Abstract: Gossypol enantiomer ratios vary considerably among Gossypium species and between different plant tissues. Breeding efforts have focused on the development of germplasm lines with a high (+)- to (-)-gossypol ratio due to the toxicity (-)-gossypol to non-ruminant animals. Interestingly, a previous study conducted in Uzbekistan reported that boll damage by Helicoverpa armigera was negatively correlated with high levels of the (+)-gossypol enantiomer in plants. USDA recently developed a germplasm line that has a high (+)- to (-)- gossypol ratio, commonly referred to as the G + line. In this study, newly-hatched H. zea larvae were fed squares (6-9 mm diam.) or bolls (15-20 mm diam.) collected from the G+ line and its genetically similar (~75%) parent line (SureGrow 747). Two and three feeding trials were conducted on squares and bolls, respectively, using 30 larvae for each cotton line and trial. After a 7-d feeding period on squares or bolls, mean larval ...
Monday, August 30, 2010. It seems there is no limit to the Rockefeller Foundations ambitions to introduce anti-fertility compounds into either existing "health-services", such as vaccines, or- as appears to be the case now- average consumer-products.. The 1985 Rockefeller Foundations annual report underlined its ongoing dedication towards finding good use for the anti-fertility substance"gossypol", or C30H30O8 - as the description reads.. Indeed, gossypol, a toxic polyphenol derived from the cotton plant, was identified early on in the Foundations research as an effective sterilant. The question was, how to implement or integrate the toxic substance into crops.. "Another long-term interest of the Foundation has been gossypol, a compound that has been shown to have an antifertility effect in men, By the end of 1985, the Foundation had made grants totaling approximately $1.6 million in an effort to support and stimulate scientific investigations on the safety and efficacy of gossypol.". In the ...
This paper presents the results of testing gossypol acetate for the possible induction of sister chromatid exchanges (SCEs) in mouse spermatogonial cells in vivofollowing a single intraperitoneal...
Background: Acquired resistance to standard chemotherapy causes treatment failure in patients with metastatic bladder cancer. Overexpression of pro-survival Bcl-2 family proteins has been associated with a poor chemotherapeutic response, suggesting that Bcl-2-targeted therapy may be a feasible strategy in patients with these tumors. The small-molecule pan-Bcl-2 inhibitor (−)-gossypol (AT-101) is known to induce apoptotic cell death, but can also induce autophagy through release of the pro-autophagic BH3 only protein Beclin-1 from Bcl-2. The potential therapeutic effects of (−)-gossypol in chemoresistant bladder cancer and the role of autophagy in this context are hitherto unknown. Methods: Cisplatin (5637rCDDP1000, RT4rCDDP1000) and gemcitabine (5637rGEMCI20, RT4rGEMCI20) chemoresistant sub-lines of the chemo-sensitive bladder cancer cell lines 5637 and RT4 were established for the investigation of acquired resistance mechanisms. Cell lines carrying a stable lentiviral knockdown of the core ...
Method: Grind sample to pass 1 mm screen taking care not to overheat. Take approximately 1 g of the sample and add 25 ml of pure acetone. Stir for a few minutes, filter, and divide filtrate into two. To one portion add a pellet of sodium hydroxide and heat in a water bath for a few minutes. A light yellow extract which does not change colour with sodium hydroxide indicates that the cottonseed meal is untreated and procedure (1) should be used. A deep orange red colour in the tube containing sodium hydroxide indicates the presence of dianilinogossypol and this requires that procedure (2) be used. Procedure (1): weigh 0.5 to 1 g of sample, depending on expected gossypol content, into a conical flask and add glass beads. Pipette in 50 ml of aqueous acetone solution, stopper the flask, and shake for one hour. Filter, discarding the first few ml of filtrate, and then pipette out duplicate aliquots into 25 ml volumetric flasks. (Take aliquots from 2 to 10 ml, again depending on expected gossypol ...
Gossypol is a toxic compound that occurs throughout the cotton plant and protects it from pests. Researchers from Texas Agricultural Experiment Station at
When removing the anti-nutrient gossypol from cottonseeds the crop could become a useful food source for humans and animals, Texas A&M University researchers found.
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Wu, D., Yu, Y., Tang, Z. and Wang, M. (1986). Pharmacokinetics of (+/-)-, (+)-, and (-)-gossypol in humans and dogs. Clinical Pharmacology and Therapeutics, 39(6), pp.613-618 ...
Background: Hormesis is a biphasic biological response characterized by the stimulatory effect at relatively low amounts of chemical compounds which are otherwise detrimental at higher concentrations. A hormetic response in larval growth rates has been observed in cotton-feeding insects in response to increasing concentrations of gossypol, a toxic metabolite found in the pigment glands of some plants in the family Malvaceae. We investigated the developmental effect of gossypol in the cotton bollworm, Helicoverpa armigera, an important heliothine pest species, by exposing larvae to different doses of this metabolite in their diet. In addition, we sought to determine the underlying transcriptional responses to different gossypol doses. Results: Larval weight gain, pupal weight and larval development time were measured in feeding experiments and a hormetic response was seen for the first two characters. On the basis of net larval weight gain responses to gossypol, three concentrations (0%, 0.016% ...
Eighteen Holstein cows were used in six simultaneous 3×3 Latin squares to determine the value of extruded-expelled cottonseed meal with lint as a replacement for whole cottonseed in diets for lactating dairy cows. Diets were: 1) WCS=whole cottonseed; 2) EC+T=extruded-expelled cottonseed meal with tallow; and 3) EC=extruded-expelled cottonseed meal. Diets were formulated to contain 17.5% CP and 40% RUP. Tallow or shelled corn was used to balance energy across diets. No differences were observed in dry matter intake, milk production, or feed efficiency among diets. Cows fed EC produced milk with a slightly higher protein percentage. Feed costs per cwt of milk were $4.17, $4.19, and $4.11 for WCS, EC+T, and EC, respectively. Extruded-expelled cottonseed meal with lint can replace whole cottonseed in diets for lactating dairy cows, if the diet is balanced for energy with either corn grain or tallow ...
Twenty-four Holstein cows were used in six 4×4 Latin squares to evaluate the effects of substituting extruded-expelled cottonseed meal (Express™) for whole cottonseed and solvent soybean meal in diets for lactating cows. No differences were observed in milk and milk component yield among treatments. Percentages of fat, protein, solids-not-fat, and lactose in milk were similar among treatments. Replacing whole cottonseed with Express™ tended to reduce milk urea nitrogen but had no effect on milk protein percentage or yield. Cow acceptability of Express™ was excellent throughout the 84-day study conducted between late June and September when ambient temperature exceeded 100EF for 35 days. Long-term storage of Express™ in a commodity barn was not a problem. In vitro analysis of Express™ revealed that it contains approximately 75% rumen undegradable protein (RUP) with an intestinally absorbable dietary protein value of 53.4%. Express™ is an excellent source of RUP, and the protein ...
The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signaling. MSI1 binds to and negatively regulates translation of Numb and APC (adenomatous polyposis coli), negative regulators of Notch and Wnt signaling respectively. Previously, we have shown that the natural product (−)-gossypol as the first known small molecule inhibitor of MSI1 that down-regulates Notch/Wnt signaling and inhibits tumor xenograft growth in vivo. Using a fluorescence polarization (FP) competition assay, we identified gossypolone (Gn) with a | 20-fold increase in Ki value compared to (−)-gossypol. We validated Gn binding to MSI1 using surface plasmon resonance, nuclear magnetic resonance, and cellular thermal shift assay, and tested the effects of Gn on colon cancer cells and colon cancer DLD-1 xenografts in nude mice. In colon cancer cells, Gn reduced Notch
Why is this program important? Research at the Texas Agricultural Experiment Station identified the enzyme that creates gossypol, which may allow it to be repressed from the cottonseed. This development means there could be 48.5 million tons of edible cottonseed created each year. Edible glandless cotton seeds serve as a suitable replacement for peanuts due to its allergy-free characteristics. These value added products of cotton could potentially generate higher income for farmers and increase the competitiveness of cotton crop in New Mexico. Edible cottonseed oil has the potential to replace soybean oil in US markets. Edible cottonseed oil also has a healthier fatty acid profile compared to other edible oil. Edible cottonseed meal is a by-product of oil production that is high in protein low in carbohydrates and fats and is a good ingredient in gluten free products ...
Texas cattle producers exploring option of feeding whole cotton plants - Texas cattle producers exploring option of feeding whole cotton plants October 21 2011 By: Blair Fannin COLLEGE STATION Texas beef producers are exploring the use of whole co...
Citation: Ye, W., Chang, H-L., Wang, L-S. Huang, Y-W., Shu, S., Dowd, M.K., Wan, P.J., Sugimoto, Y., Lin, Y. 2007. Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. Anticancer Research. 27:107-116. Interpretive Summary: Experiments were conducted with (-)-gossypol-enriched cottonseed oil to demonstrate the potential of (-)-gossypol to inhibit drug resistant cancer cell lines. Addition of 0.05% of cottonseed oil to various therapeutic agents inhibited the growth of MCF-7/adr and PCHBCEC cells. The results will be of interest to researchers developing cancer therapies. Technical Abstract: P-glycoprotein, the product of the multidrug resistance 1 gene, acts as an efflux pump and prevents sufficient intracellular accumulation of several anticancer agents. Thus, it plays a major role in multidrug cancer resistance. Using the non-radioactive cell proliferation MTS assay, none of three anticancer drug agents (Tamoxifen, ICI 182 780, ...
Malignant glioma is an aggressive disease and there is no effective therapy. repressor whereas FoxM1b and FoxM1c are both transcriptional activators[3]. FoxM1 expression Rabbit polyclonal to ACTL8. is usually gradually increasing from G0-phase and reaches peak in late G1 or Sabutoclax early S-phase. The protein levels of FoxM1 are sustained until the end of G2-phase and then it rapidly decreases during the mitosis. The altered expression accompanied with cell cycle transition highlights that this major function of FoxM1 is in regulation of cell cycle. It has been reported that FoxM1 plays an important role on regulating the transition from G1 to S phase and G2 to M phase in cell cycle progression. FoxM1 induces expression of cyclin A2 JNK1 ATF2 Cdc25A phosphatase and inhibits the stability of p21Cip1 and p27Kip1 proteins to regulate G1/S transition and DNA replication[4]. FoxM1 also regulates expression of a large array of G2/M-specific genes such as and gene promoter[10]. FoxM1 protein also ...
I had stage IIB cervical squamous cell carcinoma in June 94, treated by ext. & internal radiation. In march 95 I was diagnosed with met. to both lungs, CT scans to the head, bones and abdomen were clear. I received 3 cycles of trial combination chemotherapy (cisplatin, bleomycin, methotrexate, 5-FU) response was only noted after the 1st cycle. I need help on available therapy, both conventional and alternative. Are radiation or surgery possible options at this stage? I read about heat therapy among other alternatives (antineoplastons, glycobans,ozone, Bestatin, gossypol), need unbiased advice on those and/or other therapies. Thanks in advance Reem ...
Great Pyrenees pictures are a joy to look at if you are a dog lover. Pyrs are some of the most beautiful dogs in the world. Here are pictures of Great Pyrenees provided by members of GPCSO.
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Cottonseed meal is the byproduct remaining after cotton is ginned and the seeds crushed and the oil extracted. The remaining meal is usually used for animal feed and in organic fertilizers. However, the meal can be fed only to adult ruminants because it contains a compound called gossypol. The compound is highly toxic to monogastrics and even sometimes to calves which have less well-developed digestive systems. Card, Adrian; David Whiting; Carl Wilson; Jean Reeder (2009). "CMG Garden Notes #234 Organic Fertilizers" (PDF). Colorado State University Extension. p. 3. Archived from the original (pdf) on 21 July 2011. Retrieved 19 April 2011. Morgan, Sandra. "Gossypol Toxcicity in Livestock" (pdf). Oklahoma State University. Retrieved 19 April 2011 ...
Cottonseed oil is a cooking oil extracted from the seeds of cotton plants of various species, mainly Gossypium hirsutum and Gossypium herbaceum, that are grown for cotton fiber, animal feed, and oil. Cotton seed has a similar structure to other oilseeds such as sunflower seed, having an oil-bearing kernel surrounded by a hard outer hull; in processing, the oil is extracted from the kernel. Cottonseed oil is used for salad oil, mayonnaise, salad dressing, and similar products because of its flavor stability. Its fatty acid profile generally consists of 70% unsaturated fatty acids (18% monounsaturated, and 52% polyunsaturated), 26% saturated fatty acids. When it is fully hydrogenated, its profile is 94% saturated fat and 2% unsaturated fatty acids (1.5% monounsaturated, and 0.5% polyunsaturated). According to the cottonseed oil industry, cottonseed oil does not need to be hydrogenated as much as other polyunsaturated oils to achieve similar results. Gossypol is a toxic, yellow, polyphenolic ...
A series of indoor experiments were conducted at Massey University and AgResearch Grasslands, Palmerston North, New Zealand, to study the effect of cottonseed condensed tannin (CT) upon the nutritional value of solvent extracted cottonseed meal (CSM) for ruminant and monogastric livestock. Ruminant nutrition experiments were conducted using samples suspended in situ in the rumen of fistulated sheep and by incubating samples with rumen fluid in vitro, to study effects upon solubility and degradability of cottonseed proteins. Monogastric nutrition experiments were done initially with laboratory rats as a model for production animals such as the pig, and then with pigs. In all cases half of the animals were supplemented with polyethylene glycol (PEG; MW 3500). PEG specifically binds and inactivates CT and can be used to deduce the effects of CT by comparing control animals (CT acting) with PEG supplemented animals (CT inactivated). 1. Experimental varieties of cottonseed and of industrial CSM were ...
When they allow livestock to graze on the Bt cotton plants after harvest, thousands of sheep, goats, and buffalo died. Numerous others got sick. I visited one village where for seven to eight years they allowed their buffalo to graze on natural cotton plants without incident. But on January 3rd, 2008, they allowed their 13 buffalo to graze on Bt cotton plants for the first time. After just one days exposure, all died. The village also lost 26 goats and sheep.. One small study in Andhra Pradesh reported that all six sheep that grazed on Bt cotton plants died within a month, while the three controls fed natural cotton plants showed no adverse symptoms.. Living pesticide factories inside us?. Getting back to the Bt-toxin now circulating in the blood of North American adults and newborns-how did it get there? The study authors speculate that it was consumed in the normal diet of the Canadian middle class. They even suggest that the toxin may have come from eating meat from animals fed Bt corn-as ...
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Dr. D. Owen Rae: Current research focus is on M. avium sp paratuberculosis influence in beef cattle populations. This includes the study of diagnostics, cohort population studies, risk assessment, environmental sampling and detection of genetic markers associated with susceptibility (or resistance). Other projects relate to: bull and cow infection with T. foetus, bull development, and heifer/cow development.. Dr. Carlos A. Risco: Postpartum disorders of dairy cattle, reproductive management programs in dairy herds and gossypol toxicity in ruminants have been the focus of his research efforts at the University of Florida. In addition, he has collaborated with Dr. William Thatcher on the development and application of timed artificial insemination in dairy cattle. His research programs have been established individually and in collaboration with others. This collaborative effort has enabled him to attract both extramural and intramural research support. Several of his scientific publications have ...
How much of Potassium, K is present in Shortening, household, soybean (partially hydrogenated)-cottonseed (partially hydrogenated) in details, quantity how high or low Potassium, K nutrient content it has.
Buy Large capacity oil extraction machine from cottonseed cake from Shandong Leader Machinery Co.,Ltd.,Shea Butter Oil Plant Equipment Distributor online Service suppliers.
The fate of cottonseed rests in your hands. More than eight years ago, we wrote about a project at Texas A&M University led by Dr. Keerti Rathore to create edible cottonseed. If determined to be safe for food and the ...
Legumes and cereals contain high amounts of macronutrients and micronutrients but also anti-nutritional factors. Major anti-nutritional factors, which are found in edible crops include saponins, tannins, phytic acid, gossypol, lectins, protease inhibitors, amylase inhibitor, and goitrogens. Anti-nutritional factors combine with nutrients and act as the major concern because of reduced nutrient bioavailability. Various other factors like trypsin inhibitors and phytates, which are present mainly in legumes and cereals, reduce the digestibility of proteins and mineral absorption. Anti-nutrients are one of the key factors, which reduce the bioavailability of various components of the cereals and legumes. These factors can cause micronutrient malnutrition and mineral deficiencies. There are various traditional methods and technologies, which can be used to reduce the levels of these anti-nutrient factors. Several processing techniques and methods such as fermentation, germination, debranning, autoclaving,
The by-product of cotton processing, cottonseed was considered virtually worthless before the late 19th century.[35] While cotton production expanded throughout the 17th, 18th, and mid 19th centuries, a largely worthless stock of cottonseed grew.[35] Although some of the seed was used for planting, fertilizer, and animal feed, the majority was left to rot or was illegally dumped into rivers.[36]. In the 1820s and 1830s Europe experienced fats and oils shortages due to rapid population expansion during the Industrial Revolution and the after-effects of the British blockade during the Napoleonic Wars.[36] The increased demand for fats and oils, coupled with a decreasing supply caused prices to rise sharply.[35] Consequently, many Europeans could not afford to buy the fats and oils they had used for cooking and for lighting.[35] Many United States entrepreneurs tried to take advantage of the increasing European demand for oils and Americas increasingly large supply of cottonseed by crushing the ...