You appear to have a browser that does not support javaScript or javaScript has been disabled. Dropdown menus will not work however the links contained in the dropdowns can be accessed in the Browse the Spiral communities and collections of the home page. ...
PRIMARY OBJECTIVES:. I. To assess whether pelvic radiation therapy with concurrent cisplatin is more promising with respect to progression-free survival than pelvic radiation therapy alone in the treatment of recurrent uterine carcinoma limited to the pelvis and vagina.. SECONDARY OBJECTIVES:. I. To capture the sites of recurrence subsequent to treatment with pelvic radiation with or without concurrent weekly cisplatin in women with recurrent uterine carcinoma.. II. To estimate overall survival of patients with recurrent uterine carcinoma treated with pelvic radiation therapy with or without concurrent weekly cisplatin.. III. To estimate the prognostic significance of the location (central pelvis versus vagina) and size of the recurrence, in addition to the prognostic significance in the salvage setting of the histological subtype, grade, patient age, race, performance status, and the presence of lymph-vascular space involvement of the original tumor at the time of initial hysterectomy.. IV. To ...
Background Bile-duct ligated (BDL) rats recruit pulmonary intravascular macrophages (PIMs) and are highly susceptible to endotoxin-induced mortality. The mechanisms of this enhanced susceptibility and...
Mike, youre awesome. Thank you for finally bringing my curiosity to a close. I stumbled across NMR and was left puzzled by the explanations on the internet. They seemed to suggest that only isotopes could be utilized for NMR. Also, I was curious about the relationships between the magnitudes used in NMR. I like to find an area of physics Im not familiar with yet, and come to understand it, at least until something else grabs my attention. From other explanations on the internet about NMR it seemed like 64Cu should be eligible for NMR, but as much as I looked and looked, I couldnt find a mention of it being used with NMR. The short half life finally dawned upon me (cant believe it took me so long to realize that). And then I was curious about stabilizing half lives in general. I am contented on the topics of NMR and half life stabilization now ...
To examine the local effects of bone morphogenetic protein-4 on diverse skeletal tissues in vivo, Chinese hamster ovary tumor cells transfected with the murine bone morphogenetic protein-4 gene were implanted into athymic nude mice by injection into the subcutaneous space of the skull, intra- and extraarticular spaces of the knee, paravertebral muscles, and intramedullary space in the femur, to form experimental tumors secreting bone morphogenetic protein-4. As a control, mock vector-transfected Chinese hamster ovary tumor cells were used. Three weeks after injection, the newly formed Chinese hamster ovary tumors together with the skeletal tissues adjacent to the tumor were recovered from each site and processed for histologic examination. On the periosteum of calvaria, new bone, but no cartilage, was observed, and abundant chondrogenic cell proliferation was seen in the apophysis of the spinous process and around Ranviers groove in the knee. There were no apparent reactions to the Chinese hamster
cell free DNA and maintaining stability - posted in Molecular Biology: Hey, Im looking to start examining cell free DNA and Im worried about its purported short half life. Can anyone give me a working estimate on its half life/stability?? Has anyone used reagents like Invitrogens RNALater or Qiagens Allprotect tissue reagent, to maintain the integrity of cfDNA for longer periods of time? thanks!!
The expression of the mRNA encoding tumour necrosis factor, lymphotoxin and interleukin-6 by peripheral blood mononuclear cells was analysed. Unstimulated cells contained no detectable mRNA for these cytokines, however each mRNA was transiently expressed after stimulation with either the combination of phytohaemagglutinin and phorbol ester or the single stimulus of lipopolysaccharide. The dual stimulus yielded the stronger signal. The cytokine mRNAs had short half lives, but were stabilised following protein synthesis inhibition. Cyclosporin A completely blocked induction of lymphotoxin and partially inhibited induction of TNF and IL-6 mRNA. The features of regulation described in this paper suggest these genes belong within the early set of genes expressed following immune cell activation.
Polarized beams are an ideal probe for magnetic properties in surfaces (β-NMR). Apart from the classical spin polarized Li beams, new intense probe beams that exhibit short half life and low spin are being developed. So far 11Be and 19F have been investigated for their usefulness. Cu and Zn beams are under development.. A major facility upgrade is being started in winter 2017 to provide room for additional laser sources and diagnostics for the development of new beams.. Project leader is Dr. Phil Levy (TRIUMF Research Scientist) [email protected] assisted by Dr. Ruohong Li (TRIUMF laser physicist).. ...
2. An effective body building supplement:. One needs not to be told that SR9009 will work wonders in improving the endurance, strength, muscle hypertrophy (growth), body metabolism, fat loss and sugar level of a person. It wont be surprising to see SR9009 offer the same benefit as Cardine (GW-501516). Considering the fact that Stenabolic is effective when used solo or stacked, this means it will be an excellent supplement which can be taken alongside any steroid or SARMS cycle, and will enhance a users performance when combined with Cardarine.. SR9009 (Stenabolic) Recommended Dosage:. The optimal dosages range from 20 to 30 milligrams (mgs) per day. However, there is one drawback - due to a very short half life, you will need to space it out throughout the day for the best balance of the active substance in the body. Thus, it is best to use stenabolic every 2-4 hours, depending on the exact dosage used. For example, when the daily dosage is 30 mgs, you can take 10 mgs every 4 hours.. SR9009 ...
Marcel Dinger, Ph.D. Head, Kinghorn Centre for Clinical Genomics Laboratory Head, Genome Informatics Garvan Institute of Medical Research Conjoint Associate Professor, St Vincents Clinical School, Faculty of Medicine, UNSW Australia Long noncoding RNAs (lncRNAs) are increasingly recognized as having key regulatory roles in development and disease. However, these regulatory molecules often have short half lives and are expressed only in specific tissues or cell types, resulting in the poor…. Find out more » ...
3 Answers - Posted in: pain, fentanyl, hydrocodone, withdrawal, medication - Answer: Hi kerryanne, Fentanyl has a very short half life so the wds ...
Today, Tokyo registered a much lower iodine 131 number: 79. This is compared to 210 on the 22nd and 190 on the 23rd. Several possibilities for this are suspected. We had a big rain that washed a lot of it into reservoirs. Also the short half life of iodine 131 is another possible factor. 79 is under the legal limit for infants, but Tokyo is still wisely advising parents to avoid it for now. Other areas near Tokyo did not register such high rates at any point ...
I was on a high does of xanax for many years and my doc finally put me on some other things (valium, effexor) because xanax has a short half life. If your current dose isnt working then having a chat about your doctor might help. Maybe you need a longer lasting ant-anxiety med??? I cant give any medical advice, but I do remember that often, a few hours AFTER taking the xanax I felt more anxious than I did before I took it. Maybe this is just my funny system!! or it might be worth checking out..let us know how you go either way ...
Traditionally given via stopcock with immediate flush secondary to very short half life. Newer study showing that you may be able to mix with normal saline and give as single push, however further evidence is still needed[1] ...
Tytuł projektu: Rozbudowa i przekształcenie bibliograficznej bazy danych AGRO w bazę bibliograficzno-abstraktową z wykorzystaniem oprogramowania YADDA. Nr umowy: POIG 02.03.02-00-031/09 (okres realizacji 2009-2013 ...
Free flashcards to help memorize facts about ST major arteries of systemic circulation. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
TY - JOUR. T1 - A pharmacokinetic model including arrival time for two inputs and compensating for varying applied flip-angle in dynamic gadoxetic acid-enhanced MR imaging. AU - Zhang, Tian. AU - Runge, Jurgen H.. AU - Lavini, Cristina. AU - Stoker, Jaap. AU - van Gulik, Thomas. AU - Cieslak, Kasia P.. AU - van Vliet, Lucas J.. AU - Vos, Frans M.. PY - 2019. Y1 - 2019. N2 - Purpose Pharmacokinetic models facilitate assessment of properties of the micro-vascularization based on DCE-MRI data. However, accurate pharmacokinetic modeling in the liver is challenging since it has two vascular inputs and it is subject to large deformation and displacement due to respiration. Methods We propose an improved pharmacokinetic model for the liver that (1) analytically models the arrival-time of the contrast agent for both inputs separately; (2) implicitly compensates for signal fluctuations that can be modeled by varying applied flip-angle e.g. due to B1-inhomogeneity. Ortons AIF model is used to ...
This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central ...
Quelles conclusions peut-on tirer de cette expérience ? A ce stade, aucune, comme le reconnaissent eux-mêmes les scientifiques qui ont fait ces observations. Dailleurs, leur étude qui doit être rendue public dans ses détails en juillet prochain, ne pourra être reconnue comme valide uniquement dans la mesure où elle sera publiée dans une revue scientifique internationale avec un comité de relecture par des pairs. Cependant, même si cette récente étude ne permet pas de tirer de conclusions définitives, elle pourrait avoir un impact non-négligeable dans lapproche globale des OGM agricoles qui sont aujourdhui consommés dans le monde par des millions danimaux délevage et dêtre humains depuis leur avènement en 1996. Car en effet, pouvoir effectuer une étude dune durée aussi longue (deux ans) est tout à fait rare tant les semenciers qui en font la promotion veillent au grain, de peur que létude en question ne soit pas en leur faveur : « Des scientifiques qui découvrent ...
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Bacteria can play an important role in the formation of secondary gold grains, according to Dr Frank Reith, a geo-microbiologist at the Australian Commonwealth Science and Research Organisation (CSIRO). He believes this discovery could have a significant
A Doppler ultrasound test uses reflected sound waves to see how blood flows through a blood vessel and evaluates blood flow through major arteries and veins. It can show blocked or reduced flow of blood through narrow areas in the major arteries of the neck that could cause a stroke. It also can reveal blood clots in leg veins that could break loose and block blood flow to the lungs. ...
A Doppler ultrasound test uses reflected sound waves to see how blood flows through a blood vessel. It helps doctors assess the blood flow through major arteries and veins, such as those of the arms, legs, and neck. It can show blocked or reduced flow of blood through narrow areas in the major arteries of the neck. This...
Six years ago, large sections of Interstate 5 were shut down for days. And despite some initial fears, the Sacramento region was able to Survive I-5.
I feel fine. People have a misapprehension of what happened. I never had a heart attack or any significant problem. In the course of a more-or-less routine stress test, the EKG results showed an anomaly. As a result, I had an angiogram done, which to the cardiologists surprise - and mine, for sure - showed atherosclerosis in four arteries including one major artery that was 99% blocked.. Thats why I had the bypass surgery done. It amount to preventive revascuralization, not something done to fix existing damage to the heart. So far as anyone can tell - and I now have tests done once a year - my heart is in fine shape. I have to monitor it, of course, and Im now on medication that keeps my blood pressure under control and my cholesterol levels very low. ...
BACKGROUND AND PURPOSE: Novel stratagems to improve the efficacy of platinum coils in occluding cerebral aneurysms have primarily involved coating coils with materials thought likely to provoke more desirable histologic reactions. No investigations to date, however, have evaluated the utility of gold or vitronectin coatings, despite known endovascular histologic effects of these agents, which may be favorable for treating cerebral aneurysms. This study was conducted to evaluate the degree of endovascular histologic change associated with ultrathin gold- or vitronectin-coated platinum coils. It was hypothesized that such coatings would increase intra-aneurysmal intimal hyperplasia and the degree of luminal occlusion compared with standard platinum coils.. MATERIALS AND METHODS: The ligated carotid artery rat model was used to study 4 different aneurysm coil conditions: no coil (sham-surgery controls), uncoated platinum coil, and gold- or vitronectin-coated platinum coil. Two weeks ...
Churg-Strauss Syndrome (CSS) is a small vessel systemic vasculitis, characterised by asthma, peripheral eosinophilia, neuropathy, pulmonary infiltrates, and sinus abnormalities.1 Conventional treatment with corticosteroids and cyclophosphamide2 controls disease activity; however, relapse is frequent and the treatment is toxic. Alternative treatments include plasma exchange,3 interferon alfa,4 and intravenous immunoglobulin.5 B cell depletion with rituximab has proved effective in autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and antineutrophil cytoplasmic antibody (ANCA) associated vasculitis.6 We present two cases of patients with refractory CSS who were successfully treated with rituximab.. A 37 year old woman (case 1) presented with an 8 month history of nasal congestion, hearing loss, lymphadenopathy, rash, breast inflammation, peripheral neuropathy, abdominal pain, malaise, and weight loss. Tachydysrhythmias with poor left ventricular function on ...
Use of second-generation perflutren-based echocardiographic contrast agents (perflutren) is currently contraindicated in patients with known right-to-left, bidirectional, or transient right-to-left intracardiac shunts (intracardiac shunts) according to the U.S. Food and Drug Administration. This contraindication is primarily a result of concerns related to neurological complications and/or systemic embolism from animal data describing entrapment of perflutren lipid microspheres (,5 μm in diameter) within small arterioles and capillaries in skeletal muscles after intra-arterial injection. To date, no definitive evidence demonstrates patient safety concerns from perflutren use in humans with intracardiac shunts. We sought to evaluate the association between perflutren use and adverse events in these patients.. A retrospective cohort study was performed to evaluate the association of perflutren use (Definity, Lantheus Medical Imaging, North Billerica, Massachusetts; Optison, GE Healthcare, ...
Eight patients with Nelsons syndrome were treated with a pituitary implant of yttrium-90 or gold-198 four to 16 years after adrenal surgery. All had considerable pigmentation. One already had cranial nerve abnormalities and visual field defects and had had both a craniotomy and deep x-ray treatment. Radiographs showed that the pituitary fossa was abnormal in seven patients. A biopsy performed in six cases showed mucoid (or basophil) adenoma in all. In the four specimens examined ACTH was identified by electron microscopy or immunofluorescence, or both. Patients were followed up after pituitary implantation for three months to 12 years. All showed decreased pigmentation, and six became normal. Four patients regained normal ACTH levels and the other two studied had decreased levels. In no case did new cranial nerve disease or further sellar expansion develop since operation, and two patients showed remodelling of the sella. Complications were temporary leakage of cerebrospinal fluid and diabetes ...
Amino esters are a class of local anesthetics. They are named for their ester bond (and are unlike amide local anaesthetics). Structurally, local anesthetics consist of three molecular components: a lipophilic part an intermediate aliphatic chain a hydrophilic (amine) part The chemical linkage between the lipophilic part and the intermediate chain can be of the amide-type or the ester-type, and is the general basis for the current classification of local anesthetics. Amino esters, in reference to anesthetic agents, are rapidly metabolized in the plasma by butyrlcholinesterase to para-aminobenzoic acid derivatives, then excreted in the urine. This suggests their very short half lives. Allergy is more likely to occur with ester-type agents, as opposed to amide-type. Amino ester-type include: Cocaine Procaine (Novocain) Tetracaine (Pontocaine) Benzocaine University of Texas Med School, Pharmacology Syllabus. Katzung. 10th edition. Chapter 26 ...
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Florfenicol is a synthetic, broad-spectrum antibiotic active against many Gram-negative and Gram-positive bacteria isolated from domestic animals. It acts by binding to the 50S ribosomal subunit and inhibiting bacterial protein synthesis. Florfenicol is generally considered a bacteriostatic drug, but it exhibits bactericidal activity against certain bacterial species. In vitro studies demonstrate that florfenicol is active against the BRD pathogens M. haemolytica, P. multocida, H. somni, and M. bovis and that florfenicol exhibits bactericidal activity against strains of M. haemolytica and H. somni. The minimum inhibitory concentrations (MICs) of florfenicol were determined for BRD isolates obtained from calves enrolled in BRD field studies in the U.S. in 2006 using methods recommended by the Clinical and Laboratory Standards Institute (M31-A2). Isolates were obtained from pre-treatment nasal swabs from all calves enrolled at all four sites, post-treatment nasal swabs from treatment failures in ...
The acidity and stability constants of M(Trp)1 M: Cu2+, Cu(Bpy2)2+, and Cu(Phen3)2+ complexes, were determined by potentiometric pH titration. It is shown that the stability of the binary Cu(Trp) complexes is determined by the basicity of the carboxylate group on one side and amino group on the other side. It is demonstrated that the equilibrium, Cu(Har4)2+ + Cu(Trp) Cu(Har)(Trp) + Cu2+, is displacement due to the well known experience that mixed ligand complexes formed by a divalent 3d ion, a heteroaromatic N base and an O donor ligand possess increased stability. The other part of this displacement, which amount on average to an increased stability of the mixed ligand Cu(Bpy)(Trp) and Cu(Phen)(Trp) complexes of about 0.97 or 1.31 log unit. The stability constants of the 1:1 complexes formed between Cu2+, Cu(Bpy)2+ or Cu
A new Resources for Renters website has been launched by the City of Austins Neighborhood Housing and Community Development Department as a central location for multiple tools and programs that can help renters secure safe, fair, and affordable housing. Many Austin renters spend more than half of their income on rent, and may have specific needs, or be at risk of displacement due to a number of factors-e.g., redevelopment, rent increases, changes in property management, emergency situations, evictions, etc.. The Resources for Renters site is designed to address client needs, with information about locating rental housing, dealing with landlords, getting assistance in paying for rent or utilities, knowing legal rights when being evicted, securing transitional housing assistance, and helping children obtain support services in schools. In the future, the website will also contain contact information for affordable housing units to help households find affordable housing more easily.. For further ...
During the past decade, permanent radioactive source implantation of the prostate has become the standard of care for selected prostate cancer patients, and the techniques for implantation have evolved in many different forms. Although most implants use 125I or 103Pd sources, clinical use of 131Cs sources has also recently been introduced. These sources produce different dose distributions and irradiate the tumors at different dose rates. Ultrasound was used originally to guide the planning and implantation of sources in the tumor. More recently, CT and/or MR are used routinely in many clinics for dose evaluation and planning. Several investigators reported that the tumor volumes and target volumes delineated from ultrasound, CT, and MR can vary substantially because of the inherent differences in these imaging modalities. It has also been reported that these volumes depend critically on the time of imaging after the implant. Many clinics, in particular those using intraoperative implantation, ...
in Disease Markers (2010), 28(5), 267-72. Cervical and endometrial uterine carcinomas are heterogeneous groups of cancers, which are preceded by preneoplastic lesions. More accurate tools are needed to improve the diagnosis and to define markers ... [more ▼]. Cervical and endometrial uterine carcinomas are heterogeneous groups of cancers, which are preceded by preneoplastic lesions. More accurate tools are needed to improve the diagnosis and to define markers which may be relevant for the diagnosis, prediction of disease progression and therapeutic response.High throughput technologies for testing and validating molecular targets in cancer lesions and in their precursors are presently available. Among them, the tissue microarray (TMA) presents the advantage of a morphological control of the analyzed tissue fragment. In this article, we review the different aspects of the TMA technology with a special consideration to a uterine carcinogenesis model. [less ▲]. Detailed reference viewed: 13 (3 ...
Intravenously injected nanopharmaceuticals induce adverse cardiopulmonary reactions in sensitive human subjects and these reactions are reproducible in pigs. The underlying mechanisms are poorly understood, but a role for both the complement system and reactive macrophages has been implicated. Here we show the dominance and importance of early pulmonary intravascular macrophage clearance kinetics in adverse particle-mediated cardiopulmonary distress in pigs and irrespective of complement activation. Delaying particle recognition by macrophages within the first few minutes of injection overcome adverse reactions in pigs. This was achieved by two independent approaches: (i) changing particle geometry from a spherical shape (which trigger cardiopulmonary distress) to either rod- or disk-shape morphology and (ii) by physically adhering spheres to the surface of erythrocytes. These approaches bypasses particle surface engineering approaches to prevent robust macrophage recognition as well as the use ...
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I bought a set of gold- and diamond-encrusted eye fringe as a reward for a rigorous workout. Shaking a Highland Sling tones the pecs, Ill have you know. Anyhoo, I was practicing a flirtatious flutter when - foop! - one flew off. If I have a character flaw, its undergluing.. So my butler Peevish and Manolo, my beloved Pom, have been combing every inch of the first floor in feverish pursuit.. I let out a whoop as I spotted a sparkly bit of black fluff on the Berber, but it was just a Bedazzled millipede. Peevish has some odd hobbies.. Speaking of noble quests, I tried to find some style sense in this weeks red-carpet stakeout but came up empty-handed.. Let me Look Out Below, and Ill file my report:. ...
Trebert-Haeberlin, S., Lux, F., Karl, J., Spruss, Thilo und Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), S. 461-467 ...
In the natural environment, primary gold makes its way into soils, sediments and waterways through biogeochemical weathering and eventually ends up in the ocean. On the way bacteria can dissolve and re-concentrate gold - this process removes most of the silver and forms gold nuggets.. "Weve known that this process takes place, but for the first time weve been able to show that this transformation takes place in just years to decades - thats a blink of an eye in terms of geological time.. "These results have surprised us, and lead the way for many interesting applications such as optimising the processes for gold extraction from ore and re-processing old tailings or recycled electronics, which isnt currently economically viable.". Electron microscope images of a gold grain surface (A) and a bacterial cell on the surface of the gold (B) ...
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The head and neck receives the majority of its blood supply through the carotid and vertebral arteries. This article shall explore the arterial supply to these areas.
The AUTION HYBRID AU-4050 uses two industry trusted technologies to perform urine chemistry and sediment analysis. The chemistry analysis uses the proven AUTION™ dry pad urine chemistry strips. Sediment analysis is performed by florescent flow cytometry in two separate chambers to reduce subjective interpretations using stains to accurately identify and enumerate key formed elements. The combination of urine chemistry and sediment technology generates standardized and accurate results on one consolidated report, providing operator confidence time after time.. ...
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These x-rays show how blood flows through the aorta, the major artery leading out of the heart, and through the abdomen. The doctor will place a small catheter through the groin. Once the catheter is in place, dye is injected into it. X-ray images are taken to see how the dye move through the aorta.. This test may be performed to see if the aorta is blocked, narrowed, leaking, or enlarged (aneurysmal).. ...
Okay, so as promised, here is the story of my Oma and why she ended up spending most of our Perth holiday in hospital.. So the background of the story is that Oma has had this terrible cough for months and months now, and it has been progressively getting worse. My uncle, who is a doctor, had been chasing this up and getting her booked in for various check-ups and investigations to get to the bottom of it.. Two weeks before we left for Perth, we were told that Oma had been in for scans looking at her lungs etc. for this cough (which by the way turned out to be totally unrelated to what happened next), and theyd found something they hadnt expected to see at all. A large growth, nestled around a major artery that runs from the heart to the leg. There was a possibility it may be cancerous. It was a bit of a blow to us all, especially considering that in the same week we also received news that one of my dads sisters had been diagnosed with breast cancer, and would be having a partial mastectomy ...
The veins of the lower limb drain deoxygenated blood and return it to the heart. They can be divided into two groups; deep and superficial. Deep veins are located underneath the deep fascia of the lower limb, accompanying the major arteries.
... is a condition in which plaque buildup causes hardening and narrowing of major arteries. This eMedTV article offers an overview of this topic, including symptoms, diagnosis, and what can happen if the condition is left untreated.
Angioplasty is designed to improve the flow of blood through your hearts major arteries. Brookhaven Heart is here for you, just call us at 631-654-3278.