Reiter EO, Brown RS, Longcope C, Beitins IZ. Male-limited familial precocious puberty in three generations. Apparent Leydig-cell autonomy and elevated glycoprotein hormone alpha subunit. N Engl J Med. 1984 Aug 23; 311(8):515-9 ...
Human thyrotropin (TSH), luteotropin (LH), follitropin (FSH), and chorionic gonadotropin are members of the heterodimeric glycoprotein hormone family. The common α subunit forms noncovalent heterodimers with different β subunits. Two novel human glycoprotein hormonelike genes, α2 (A2) and β5 (B5), recently have been identified. Using a yeast two-hybrid assay, the two subunits were found as potential heterodimerization partners. Immunological analyses confirmed the heterodimerization of A2 and B5 in transfected cells and their colocalization in the anterior pituitary. Recombinant A2/B5 heterodimeric glycoproteins, purified using cation exchange and size fractionation chromatography, activated human TSH receptors, but not LH and FSH receptors, and showed high affinity to TSH receptors in a radioligand receptor assay. The heterodimer also stimulated cAMP production and thymidine incorporation by cultured thyroid cells and increased serum thyroxine levels in TSH-suppressed rats in vivo. This new ...
Yeast two-hybrid testing and RT-PCR analyses. Interactions between A2 and different glycoprotein hormone subunits were assessed in the yeast two-hybrid system using pGBT9 GAL4-binding domain (BD) and pGADGH GAL4-activation domain (AD) vectors (12). Specific binding of different protein pairs was evaluated based on the activation of GAL1-HIS3 and GAL4-lacZ reporter genes (Clontech Laboratories Inc., Palo Alto, California, USA). The mature region of human A2 cDNA was fused to the GAL4-AD in a yeast shuttle vector, pGADGH. Similarly, cDNAs encoding other glycoprotein hormone subunits without the signal peptides were fused to the GAL-4-BD of the pGBT9 vector. Specific interactions of different protein pairs were evaluated based on the activation of the GAL1-HIS3 reporter gene in medium lacking leucine, tryptophan, and histidine but in the presence of 5 mM 3-aminotriazole (13). At least 10 different colonies expressing each pair of fusion proteins were tested.. For RT-PCR analysis of A2 and B5 mRNA ...
The pituitary glycoprotein hormones are thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Hormone-free serum is required for use as a matrix for standards in the radioimmunoassay of hormones. The glycoprotein hormones are difficult to remove from serum by conventional techniques. We exploited the specific binding of carbohydrates by lectins to extract glycoprotein hormones from human serum. Passing serum over Concanavalin A Sepharose efficiently removed lutropin and the beta subunit of choriogonadotropin. Wheat-Germ Lectin Sepharose completely removed these, and also follitropin and thyrotropin. The latter treatment is shown to provide a suitable matrix for standards in radioimmunoassays of the four hormones.
|strong|Mouse anti Human hCG anibody, clone INN-hCG-72|/strong| recognises exclusively free hCG alpha. It reacts with the alpha 6 epitope on hCG alpha. No cross reaction is observed with holo-hCG in d…
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Complete information for GPHA2 gene (Protein Coding), Glycoprotein Hormone Subunit Alpha 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Rule 1: The oxidation number of an element in its free (uncombined) state is zero - for example, Al(s) or Zn(s). This is also true for elements found in nature as diatomic (two-atom) elements and for sulfur, found as: S8. Rule 2: The oxidation number of a monatomic…. ...
Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Involved in gametogenesis and steroidogenesis.
Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Synonyms for Follitropin alfa in Free Thesaurus. Antonyms for Follitropin alfa. 1 synonym for follicle-stimulating hormone: FSH. What are synonyms for Follitropin alfa?
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity ...
The N-methyl-d-aspartate receptor plays a critical role in the formation and maintenance of synapses during brain development. In the rodent, changes in subunit expression and assembly of the heteromeric receptor complex accompany these maturational processes. However, little is known about N-methyl-d-aspartate receptor subunit expression during human brain development. We used in situ hybridization to examine the distribution and relative abundance of NR1, NR2A and NR2B subunit messenger ribonucleic acids in the hippocampal formation and adjacent cortex of 34 human subjects at five stages of life (neonate, infant, adolescent, young adult and adult). At all ages, the three messenger ribonucleic acids were expressed in all subfields, predominantly by pyramidal neurons, granule cells and polymorphic hilar cells. However, their abundance varied across ontogeny. Levels of NR1 messenger ribonucleic acid in CA4, CA3 and CA2 subfields were significantly lower in the neonate than all other age groups. In the
The N-methyl-d-aspartate receptor plays a critical role in the formation and maintenance of synapses during brain development. In the rodent, changes in subunit expression and assembly of the heteromeric receptor complex accompany these maturational processes. However, little is known about N-methyl-d-aspartate receptor subunit expression during human brain development. We used in situ hybridization to examine the distribution and relative abundance of NR1, NR2A and NR2B subunit messenger ribonucleic acids in the hippocampal formation and adjacent cortex of 34 human subjects at five stages of life (neonate, infant, adolescent, young adult and adult). At all ages, the three messenger ribonucleic acids were expressed in all subfields, predominantly by pyramidal neurons, granule cells and polymorphic hilar cells. However, their abundance varied across ontogeny. Levels of NR1 messenger ribonucleic acid in CA4, CA3 and CA2 subfields were significantly lower in the neonate than all other age groups. In the
Follitropin Alfa - Get up-to-date information on Follitropin Alfa side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Follitropin Alfa
The Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH) and Chorionic Gonadotropin (1,2). FSH controls the growth and maturation of follicles in the females and spermatogenesis in males. FSH is a heterodimer and shares a common alpha sub-unit with the other glycoprotein hormones in its family (3) and has a specific beta subunit that confers receptor specificity and biological activity to the hormone (4). FSH acts through the FSH receptor (FSHR), a G protein coupled receptor (GPCR) that is expressed exclusively on the granulosa cells of ovaries and Sertoli cells of the testis (5) in humans. FSH signaling involves activation of adenylyl cyclase activity and the increased production of cAMP. This activates the cAMP dependent protein kinases such as PKA (6), PKB (Akt) and PKC (7) that, in turn, lead to the phosphorylation of specific transcription factors ...
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The leukocyte integrins play a critical role in a number of cellular adhesive interactions during the immune response. We describe here the isolation and characterization of the chicken beta 2 (CD18) subunit, common to the leukocyte integrin family. The deduced 748-amino-acid sequence reveals a transmembrane protein with 65% and 64% identity with its human and murine homologues, respectively. The chicken beta 2 can associate on the cell surface with the human alpha subunit of LFA-1 and yields a hybrid molecule capable of binding to purified ICAM-1 and ICAM-3 ...
Human Chorionic Gonadotropin is also called Human Gonadotropin. Its a glycoprotein hormone produced during pregnancy, and also made by the embryo just after conception and then by the trophoblast.
As part of a more extensive study of the immune response in children with neuroblastoma, serum immunoglobulin and alpha-glycoprotein levels were measured in 58 patients. Twenty-nine children were studied at diagnosis, 18 at some time during the first
Clone Determination ME.116. Immunogen hLH-α subunit. Immunoglobulin Class IgG1κ. Specificity Human Luteinizing Hormone - Alpha. Purification Protein A chromatography from ascites. pI 5.0-8.0. Buffer 0.15M PBS. Preservatives None. Applications ELISA. Working dilution Determined by user. Storage Store at -20ºC to -80ºC, avoid repeat freeze-thaw cycles. FOR RESEARCH AND IN VITRO USE ONLY Contact us for bulk pricing information at 207-797-5454 or [email protected] ...
This medication contains follicle-stimulating hormone (FSH) and is used to treat certain fertility problems in women. Follitropin alfa helps stimulate healthy ovaries to produce eggs. This medication is usually used in combination with another hormone (hCG) to bring about the growth and release of a mature egg...
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Easy to read patient leaflet for Follitropin Alfa. Includes indications, proper use, special instructions, precautions, and possible side effects.
What is this medicine? LUTROPIN ALFA (lu TRO pen AL fa) is a man-made hormone. It is used to treat women who have not been able to become pregnant because of
HCG is a glycoprotein hormone that is produced during pregnancy by the embryo shortly after conception and later in large amounts, by the placenta.
I have already come across a post on the board where someone said she was on Repronex for 20 days, so thats given me some peace of mind. Ive been so worried that they would just tell me to screw this cycle and give up. And whether that would mean that were done with this avenue (injectibles / IUI). Sometimes I think that being a scientist is a really bad thing in this arena because I know too much about things that could potentially happen. The meds arent working? I must be making neutralizing antibodies. So the FSH will never work, and Ive totally screwed myself because I cant ovulate, and now cant take gonadotropins so no IUI OR IVF. Despite the fact that there is no published paper even remotely suggesting that. Well, except in baboons taking human gonadotropins. Im such a dork ...
Learn about Follistim AQ (Follitropin Beta) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Aluris snake venom is an injection free solution for younger looking skin! to find out more about it click the link above!. Dermaxyl® is an anti-wrinkle ingredient that is a patented form of palmitoyl oligopeptide. dermaxyl® may be found as the primary ingredient in a number of anti. Best hyaluronic acid serum for your face. our anti wrinkle facial skin care brings deep hydration, boost collagen production & reduces fine lines... Dermaxyl® is an anti-wrinkle ingredient that is a patented form of palmitoyl oligopeptide. dermaxyl® may be found as the primary ingredient in a number of anti. Get visibly firmer, younger-looking skin every morning. moisturize and fight 7 signs of aging with olay total effects night firming treatment.. 10 health benefits of broccoli [infographic] 10-day detox diet cookbook, 343 pages, little brown: 100% all natural flax n whey vanilla nut, 36 servings, mrm.. ...
The glycoprotein hormones (LH, hCG, FSH, and TSH) have a common 92-amino acid alpha-subunit which is noncovalently linked to a hormone-specific beta-subunit. Synthetic peptides of the alpha-subunit have been shown to inhibit binding of [125I]iodo-hCG to rat ovarian membrane and [125I]iodo-TSH to human thyroid membrane preparations. Synthetic overlapping peptides of the alpha-subunit of hCG were prepared by solid phase techniques and tested in a standard in vitro rat Leydig cell bioassay. Three regions in the alpha-subunit (alpha 1-15, alpha 30-45, and alpha 71-85) were found to stimulate testosterone production. All three regions correlate with inhibition of hCG binding to ovarian receptors, but subtle differences exist between the binding sites and effector sites. These data indicate that the glycoprotein alpha-subunit has intrinsic bioactivity.
... Definition Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone, which similar in structure to luteinizing hormone tha
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1. (a.) Arising by birth; having an origin; born.. 2. (a.) of or pertaining to ones birth; natal; belonging to the place or the circumstances in which one is born; -- opposed to foreign; as, native land, language, color, etc.. 3. (a.) Born in the region in which one lives; as, a native inhabitant, race; grown or originating in the region where used or sold; not foreign or imported; as, native oysters, or strawberries.. 4. (a.) Original; constituting the original substance of anything; as, native dust.. 5. (a.) Conferred by birth; derived from origin; born with one; inherent; inborn; not acquired; as, native genius, cheerfulness, simplicity, rights, etc.. 6. (a.) Naturally related; cognate; connected (with).. 7. (a.) Found in nature uncombined with other elements; as, native silver.. 8. (a.) Found in nature; not artificial; as native sodium chloride.. 9. (n.) One who, or that which, is born in a place or country referred to; a denizen by birth; an animal, a fruit, or vegetable, produced in a ...
EPO, Erythropoietin, is an acidic glycoprotein hormone with a molecular mass of 34 kD. It is a cytokine for erythrocyte (red blood cell) precursors in…
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In cultured chicken myotubes, calcitonin gene-related peptide (CGRP), a peptide present in spinal cord motoneurons, increased by 1.5-fold the number of surface acetylcholine receptors (AChRs) and by threefold AChR alpha-subunit mRNA level without affecting the level of muscular alpha-actin mRNA. Cholera toxin (CT), an activator of adenylate cyclase, produced a similar effect, which did not add up with that of CGRP. In contrast, tetrodotoxin, a blocker of voltage-sensitive Na+ channels, elevated the level of AChR alpha-subunit mRNA on top of the increase caused by either CGRP or CT. 12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, markedly decreased the cell surface and total content of [125I]alpha BGT-binding sites and reduced the rate of appearance of AChR at the surface of the myotubes without reducing the level of AChR alpha-subunit mRNA. Moreover, TPA inhibited the increase of AChR alpha-subunit mRNA caused by tetrodotoxin without affecting that produced by CGRP ...
One telltale signal of heartburn is that the burning sensation can really feel worse if you bend over or lie down. In my personal expertise with 3 pregnancies my first symptom was temper swingsemotional lability (sorry Marc Bodnick !) a few week after conception. We owe an apology for issues mentioned in right nows vlog. Ovidrel (recombinant chorionic gonadotropin alpha, rhCG), Cetrotide (cetrorelix acetate), Ganirelix (ganerelix acetate), and Luveris (lutropin alpha) are considered early pregnancy and diazepam and investigational to be used in males, including however not limited to any kind of male infertility. To do so, your provider may order an ultrasound to establish the place the embryo is implanted. Gynecologists and medical experts often quote the due date on the prescription of the primary go to. You may need to go and see your physician in case your interval would not arrive and you still maintain getting unfavourable pregnancy checks. In case you planned the breeding, you are ...
Public Release: 8-Jan-2016 Researchers determine mechanism that triggers normal and abnormal hormone production American Society for Biochemistry and Molecular Biology IMAGE: Model of a glycoprotein hormone receptor (white backbone ribbon) with bound hormone and the activating antibody visualizes a potential arrangement and the principle mechanism of glycoprotein hormone receptor activation. view more Credit: Journal…
Erythropoietin: Glycoprotein hormone, secreted chiefly by the kidney in the adult and the liver in the fetus, that acts on erythroid stem cells of the bone marrow to stimulate proliferation and differentiation.
|p|Tomato lectin is a very stable single subunit glycoprotein containing about 50 percent arabinose and galactose and may form multimeric aggregates in solution.
Tomato lectin is a very stable single subunit glycoprotein containing about 50 percent arabinose and galactose and may form multimeric aggregates in solution.
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hCG beta 1 epitope小鼠单克隆抗体[INN-hCG-2](ab11388)可与人样本反应并经ELISA, IHC, RIA实验严格验证,被1篇文献引用并得到1个独立的用户反馈。
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The cDNA encoding the glycoprotein α (GPα) subunit of tilapia (Oreochromis mossambicus) was partially cloned using RACE-polymerase chain reaction (PCR) technique. The amplified cDNA was found to be 583 bases long, and to consist of a portion of the signal peptide, the full sequence encoding the mature peptide (94 amino acids) and the 3′ untranslated region. Northern blot analysis revealed a single band of approximately 600 bp. Alignment of the deduced amino acids of the mature protein showed that the tilapia GPα subunit shares more than 80% identity with that of other perciform fish (i.e. striped bass, sea bream and yellowfin porgy) and less than 70% with that of more taxonomically remote fish and other vertebrates. Exposure of dispersed tilapia pituitary cells to salmon gonadotropin-releasing hormone (sGnRH) elevated GPα mRNA levels via both PKC and cAMP-protein kinase A (PKA) pathways. The transcript levels were also regulated by pituitary adenylate cyclase activating polypeptide (PACAP) and
Giant invasive pituitary adenomas are rare tumors that have been reported to extensively involve the cranial base, as well as other intra- and extra-cranial structures, making surgical resection by traditional approaches impossible. We report two cases, each of a giant invasive adenoma involving the entire length of the clivus and adjacent structures that was resected via a transfacial approach with excellent results. Both tumors were in middle-aged men; one was nonsecreting, and the other secreted follicle-stimulating hormone alpha-subunit. Most previously reported giant invasive adenomas have been prolactinomas. Both tumors were resected via a transfacial approach that incorporated an osteoplastic maxillotomy with palatal division and a posterior pharyngeal incision that provided exposure from the suprasellar region to C2. Both of the patients received postoperative radiation and have done very well. Their cosmetic results were excellent. The complications included postoperative meningitis in one
The radioactively labelled constituents present in bone matrix were compared 12 days after injection of either [(14)C]glucosamine or plasma [(14)C]glycoprotein. Both precursors are utilized in the synthesis of organic matrix by bone tissue. Cortical bone from animals injected with [(14)C]glucosamine contains radioactivity derived from glucosamine and plasma glycoproteins and all glycoprotein fractions are labelled. Plasma [(14)C]glycoprotein labels the less acidic glycoproteins to a greater extent than the more acidic components. An antibody has been raised against the less-acidic-glycoprotein fraction of bone. The latter contains a glycoprotein of alpha-mobility that appears to be concentrated specifically in bone tissue and which is present also in plasma. This alpha-glycoprotein accounts for a large proportion of the components labelled and retained in bone matrix after [(14)C]glucosamine injection.
ROCKLAND, MD - Sept. 30 /PRNewswire/ -- Serono, Inc. announced today that the Reproductive Health Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) issued a favorable recommendation for Luveris® in Seronos proposed indication of follicular development. Luveris® (lutropin alfa for injection) administered with follitropin alfa for injection, is proposed for the indication of stimulation of follicular development in infertile hypogonadotropic hypogonadal (HH) women with profound luteinizing hormone deficiency (LH The FDA had previously recommended that Serono study an endpoint of ovulation rates, an endpoint frequently used for products in ovulation induction. However, the Committee agreed that in this rare patient population the endpoint of follicular development was appropriate.. "We are very pleased with the recommendation of the Advisory Committee supporting the efficacy of Luveris® for follicular development in this rare patient population and will continue to work ...
... Recombinant human glycoprotein Ib alpha Residues 17 - 306 None of the tyrosines at positions 292, 294, 295 is sulfated 40 ug Alternative names: GpIb CD42B-alpha Send an email to [email protected]