The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
SWISS-MODEL Repository entry for A0K321 (GCSP_BURCH), Glycine dehydrogenase (decarboxylating). Burkholderia cenocepacia (strain HI2424)
In this study, systematic inhibitor response to ErbB missense mutations in gastric cancer (GC) is investigated by combining computational analysis and experimental assay. The response profile is created for 6 ATP-competitive, reversible inhibitors against 9, 17, 5 and 17 GC-associated missense mutations of ErbB1, ErbB2, ErbB3 and ErbB4 kinase domains, respectively. From the profile a number of p...
Mutations in the GLDC gene account for about 80 percent of all cases of glycine encephalopathy. More than 40 mutations have been identified in affected individuals. Many of these genetic changes alter single amino acids in glycine dehydrogenase. For example, the most common GLDC mutation in the Finnish population replaces the amino acid serine with the amino acid isoleucine at position 564 in the enzyme (also written as Ser564Ile or S564I). Other mutations insert or delete genetic material in the GLDC gene, or disrupt how genetic information from the gene is spliced together to make a blueprint for producing glycine dehydrogenase.. Some GLDC mutations lead to the production of a nonfunctional version of glycine dehydrogenase, while other mutations reduce but do not eliminate the enzymes activity. When an altered version of this enzyme is incorporated into the glycine cleavage enzyme complex, it prevents the complex from breaking down glycine properly. As a result, excess glycine can build up to ...
The estimation of pharmacological agents to reache its targets is important in drugs trials. This can be done by the ADME techniques based on blood or tissue harvesting and subsequent drug and metabolite analysis. This approach is less than a prefect because plasma levels of compound often do not reflect concentrations in specific tissue, because of the presence of physicochemical barriers such as between blood and brain ...
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Sigma-Aldrich offers abstracts and full-text articles by [I V Fedorenko, E V Abel, J M Koomen, B Fang, E R Wood, Y A Chen, K J Fisher, S Iyengar, K B Dahlman, J A Wargo, K T Flaherty, J A Sosman, V K Sondak, J L Messina, G T Gibney, K S M Smalley].
Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes. CHS Chialvo, R Che, D Reif, A Motsinger-Reif, LK R...
rs4646 is a SNP in the CYP19A1 gene on chromosome 15. The CYP19A1 gene is probably the primary one studied to date as possibly associated with the efficacy or toxicity of aromatase inhibitors such as letrozole, anastrozole and exemestane. The effect of CYP19A1 variant in response to such inhibitors has produced conflicting results in studies (see citations below), and although rs4646 may be perhaps the best studied CYP19A1 variant, there is to date no robust or replicated conclusion about it with respect to aromatase inhibitor response.[PMID 26203310 ...
Auxin regulates a host of plant developmental and physiological processes, including embryogenesis, vascular differentiation, organogenesis, tropic growth, and root and shoot architecture. Genetic and biochemical studies carried out over the past decade have revealed that much of this regulation involves the SCFTIR1/AFB-mediated proteolysis of the Aux/IAA family of transcriptional regulators. With the recent finding that the TRANSPORT INHIBITOR RESPONSE1 (TIR1)/AUXIN SIGNALING F-BOX (AFB) proteins also function as auxin receptors, a potentially complete, and surprisingly simple, signaling pathway from perception to transcriptional response is now before us. However, understanding how this seemingly simple pathway controls the myriad of specific auxin responses remains a daunting challenge, and compelling evidence exists for SCFTIR1/AFB-independent auxin signaling pathways ...
Auxin regulates a host of plant developmental and physiological processes, including embryogenesis, vascular differentiation, organogenesis, tropic growth, and root and shoot architecture. Genetic and biochemical studies carried out over the past decade have revealed that much of this regulation involves the SCFTIR1/AFB-mediated proteolysis of the Aux/IAA family of transcriptional regulators. With the recent finding that the TRANSPORT INHIBITOR RESPONSE1 (TIR1)/AUXIN SIGNALING F-BOX (AFB) proteins also function as auxin receptors, a potentially complete, and surprisingly simple, signaling pathway from perception to transcriptional response is now before us. However, understanding how this seemingly simple pathway controls the myriad of specific auxin responses remains a daunting challenge, and compelling evidence exists for SCFTIR1/AFB-independent auxin signaling pathways ...
1OMO: Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
1OMO: Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
Scientists at the Helmholtz Zentrum M nchen say that metabolites analysis is needed for gender-specific treatments. Study published in PLoS Genetics.
Kyu Y. Rhee is the author of this article in the Journal of Visualized Experiments: A Tandem Liquid Chromatography-Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus