Shop Phosphoglycerate transport system transcriptional regulatory protein ELISA Kit, Recombinant Protein and Phosphoglycerate transport system transcriptional regulatory protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Catalyzes the hydrolysis of glucosylglycerate (GG) to glycerate and glucose (PubMed:25341489, PubMed:31316802). Involved in recovery from nitrogen starvation by promoting the rapid mobilization of the glucosylglycerate that accumulates under these conditions (PubMed:25341489). Can also hydrolyze mannosylglycerate (MG), with tenfold lower efficiency (PubMed:31316802).
Requires Mg2+. The enzyme from Pyrococcus horikoshii is specific for α-D-mannosyl-3-phosphoglycerate and forms part of the pathway for the synthesis of mannosylglycerate
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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Human (Homo sapiens) のGLYCTK (glycerate kinase)遺伝子を含むベクター、レンチウイルス、アデノウイルス、 (AAV) アデノ随伴、アデノ随伴ウイルス、MMLV レトロウイルス,、piggyBac, shRNA、gRNA、 ガイドRNA、 CRISPR-Cas9 、クリスパー、プラスミド
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The reaction pathway for the conversion of glycerol into different products, namely glyceraldehyde, glyceric acid, glycolic acid, mesoxalic acid and tartronic acid was studied by means of electrochemistry. Multiple Pulse Amperometry technique was used to control the potential during the electrooxidation reaction. The estimation of the transfer function was realized on the basis of dynamic models for the oxidation reaction. The equations obtained in the s-domain were expressed in the time domain using Inverse Laplace transformation to describe the variation of glycerol and products concentration ...
Archibald Couper was able to deduce with his newly-acquired empirical expertise with chemistry that Carbon is tetravalent, bonds with other Carbons, and comes in pairs that are essentially one (we now know they really are one); that Oxygen also comes in such pairs; and that Hydrogen has no affinity for itself when united to another element. With this knowledge, Couper devised surprisingly accurate structures for molecules made up of these three elements. He knew the skeleton would have to be made of the self-linking Carbons, and the other atoms should be distributed according to the rules above.. Thus, in 1858, he composed a structural formula for glycerine that is much like the one we use now that has been confirmed experimentally. Couper wrote CH(OH)2-CH2-CH2OH; the actual formula is CH2OH-CHOH-CH2OH.. He was similarly close for glyceric acid, a product of the oxidation of glycerine. Instead of having two OH groups attached to the top carbon as Couper postulated, one of the OH groups ...
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Shop Glycerate dehydrogenase ELISA Kit, Recombinant Protein and Glycerate dehydrogenase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
CP000247.PE567 Location/Qualifiers FT CDS 604592..605737 FT /codon_start=1 FT /transl_table=11 FT /locus_tag=ECP_0574 FT /product=glycerate kinase 1 FT /EC_number=2.7.1.31 FT /db_xref=EnsemblGenomes-Gn:ECP_0574 FT /db_xref=EnsemblGenomes-Tr:ABG68603 FT /db_xref=GOA:A0A454A230 FT /db_xref=InterPro:IPR004381 FT /db_xref=InterPro:IPR018193 FT /db_xref=InterPro:IPR018197 FT /db_xref=InterPro:IPR036129 FT /db_xref=UniProtKB/TrEMBL:A0A454A230 FT /protein_id=ABG68603.1 FT /translation=MKIVIAPDSFKESLSAEKCCQAIKAGFSTIFPDAHYICLPIADGG FT EGTVDAMVAATGGNIVTLEVCGPMGETVNAFYGLTGDGKTAVIEMAAASGLMLVAPEKR FT NPLLASSFGTGELIRHALDNGIRHIILGIGGSATVDGGMGMAQALGVRFLDADGQVLAA FT NGGNLARVASIEMDECDPRLANCHIEVACDVDNPLVGARGAAAVFGPQKGATPEMVEEL FT EQGLQNYARVLQQLTEINVCQMAGGGAAGGMGIAAAVFLNADIKPGIEIVLNAVNLAQA FT VQGAALVITGEGRIDSQTAGGKAPLGVASVAKQFNVPVIGIAGVLGDGVEVVHQYGIDA FT VFSILPRLAPLAEVLASGETNLFNSARNIACAIKIGQGIKN MKIVIAPDSF KESLSAEKCC QAIKAGFSTI FPDAHYICLP IADGGEGTVD AMVAATGGNI 60 VTLEVCGPMG ETVNAFYGLT ...
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Kernels of wild-type maize (Zea mays L.) shrunken-1 (sh1), deficient in the predominant form of endosperm sucrose synthase and shrunken-2 (sh2), deficient in 95% of the endosperm ADP-glucose pyrophosphorylase were grown in culture on sucrose, glucose, or fructose as the carbon source. Analysis of the endosperm extracts by gas-liquid chromatography revealed that sucrose was present in the endosperms of all genotypes, regardless of carbon supply, indicating that all three genotypes are capable of synthesizing sucrose from reducing sugars. The finding that sucrose was present in sh1 kernels grown on reducing sugars is evidence that shrunken-1 encoded sucrose synthase is not necessary for sucrose synthesis. Shrunken-1 kernels developed to maturity and produced viable seeds on all carbon sources, but unlike wild-type and sh2 kernels grown in vitro, sucrose was not the superior carbon source. This latter result provides further evidence that the role of sucrose synthase in maize endosperm is primarily ...
REFERENCES. ADELMAN RC, BALLARD FJ AND WEINHOUSE S. 1967. Purification and properties of rat liver fructokinase. J Biol Chem 242: 3360-3365. [ Links ] ARAÚJO APQC. 2004. Doenças metabólicas com manifestações psiquiátricas. Rev Psiq Clin 31: 285-289. [ Links ] BONHAM JR, STEPHENSON TJ, CARPENTER KH, RATTENBURY JM, CROMBY CH, POLLITT RJ AND HULL D. 1990. D(+)-Glyceric Aciduria: Etiology and Clinical Consequences. Pediatr Res 28: 38-41. [ Links ] BRANDT NJ, BRANDT S, RASMUSSEN K AND SCHNOHEYDER F. 1974. Hyperglycericacidaemia with hyperglycinaemia: a new inborn error of metabolism. Br Med J 4: 344. [ Links ] BRANDT NJ, RASMUSSEN K, BRANDT S, KOLVRAA S AND SCHONHYDER F. 1976. D-glyceric-acidaemia and non-ketotic hyperglycinaemia. Clinical and laboratory findings in a new syndrome. Acta Paediatr Scand 65: 17-22. [ Links ] CAMP KM, LLOYD-PURYEAR MA AND HUNTINGTON KL. 2012. Nutritional treatment for inborn errors of metabolism: Indications, regulations, and availability of medical foods and ...
SWISS-MODEL Template Library (SMTL) entry for 2wvm.1. H309A mutant of Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 in complex with GDP-alpha-D-Mannose and Mg(II)
C3 PLANTS CO2 is first incorporated into a 3-carbon compound, PGA (Phosphoglyceric acid). RUBISCO enzyme involved in photosynthesis, & also involved in uptake of CO2. Fix carbon by attaching CO2 to RuBP using the Calvin cycle. E.g. Most mesophytic plants are C3. C4 PLANTS CO2 is first incorporated into 4-carbon compound, OAA (Oxaloacetic acid). Uses […]. ...
Hinge-bending movements in proteins comprising two or more domains form a large class of functional movements. Hinge-bending regions demarcate protein domains and collectively control the domain movement. Consequently, the ability to recognise sequence features of hinge-bending regions and to be able to predict them from sequence alone would benefit various areas of protein research. For example, an understanding of how the sequence features of these regions relate to dynamic properties in multi-domain proteins would aid in the rational design of linkers in therapeutic fusion proteins. The DynDom database of protein domain movements comprises sequences annotated to indicate whether the amino acid residue is located within a hinge-bending region or within an intradomain region. Using statistical methods and Kernel Logistic Regression (KLR) models, this data was used to determine sequence features that favour or disfavour hinge-bending regions. This is a difficult classification problem as the number of
Abstract: Glycosyltransferases (GTs) play a central role in nature. They catalyze the transfer of a sugar moiety to a broad range of acceptor substrates. GTs are highly selective enzymes, allowing the recognition of subtle structural differences in the sequences and stereochemistry of their sugar and acceptor substrates. We report here a series of structural snapshots of the reaction center of the retaining glucosyl-3-phosphoglycerate synthase (GpgS). During this sequence of events, we visualize how the enzyme guides the substrates into the reaction center where the glycosyl transfer reaction takes place, and unveil the mechanism of product release, involving multiple conformational changes not only in the substrates/products but also in the enzyme. The structural data are further complemented by metadynamics free-energy calculations, revealing how the equilibrium of loop conformations is modulated along these itineraries. The information reported here represent an important contribution for the ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
4 cyl. 5 speed autmatic trans. extended cab. the problem i am having is. i have lost at least 4 mpgs. i have changed plugs & wires,air filter, ...
Holzer, H. & Holldorf, A. (1957). „Isolation of a D-glycerate dehydrogenase, its properties, and its use for the optical determination of hydroxypyruvate in the presence of pyruvate. Biochem. Z. 329: 292-312. PMID 13522707 ...
Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ...
TY - JOUR. T1 - Anion activation of 3-phosphoglycerate kinase requires domain closure. AU - Szilágyi, Andrea N.. AU - Vas, M.. PY - 1998/6/9. Y1 - 1998/6/9. N2 - 3-Phosphoglycerate kinase is a typical two-domain hinge-bending enzyme, which is known to be regulated by multivalent anions. Here a relationship between this regulation and the hinge-bending domain closure is proposed on the basis of enzyme kinetic analysis and molecular modeling. Activation of the pig muscle enzyme at low concentrations and inhibition at high concentrations of various anionic analogues of the substrate 3- phosphoglycerate or of the nonsubstrate metal-free ATP are described by a two-site model assuming separate sites for activation and inhibition, respectively. Kinetic experiments with various pairs of analogues suggest the presence of a common site for activation by all effectors, separate from the catalytic site for 3-phosphoglycerate; and a common site for inhibition, except for metal-free ATP, identical with the ...
The selective oxidation of biorenewable alcohols with molecular oxygen over gold catalysts in liquid water offers a sustainable, environmentally-benign alternative to traditional processes that utilize expensive inorganic oxidants and harmful organic solvents. For example, oxidation of glycerol, a byproduct of biodiesel production, to glyceric acid is one possible conversion strategy to form value added chemicals. The oxidation of glycerol by molecular oxygen in the aqueous phase over Au/TiO2 was investigated in both a batch reactor and a continuous upflow fixed bed reactor. The effects of catalyst particle size, gas flow rate, liquid flow rate, reaction temperature, dioxygen pressure, and solution pH were examined in the fixed bed system. The unique hydrodynamics of the fixed bed system allowed for secondary oxidation products such as tartronic acid and oxalic acid to form in substantial amounts, which contrasts the product distribution observed in a batch system. These results suggest that ...
TY - JOUR. T1 - Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. AU - Locasale, Jason W.. AU - Grassian, Alexandra R.. AU - Melman, Tamar. AU - Lyssiotis, Costas A.. AU - Mattaini, Katherine R.. AU - Bass, Adam J.. AU - Heffron, Gregory. AU - Metallo, Christian M.. AU - Muranen, Taru. AU - Sharfi, Hadar. AU - Sasaki, Atsuo T.. AU - Anastasiou, Dimitrios. AU - Mullarky, Edouard. AU - Vokes, Natalie I.. AU - Sasaki, Mika. AU - Beroukhim, Rameen. AU - Stephanopoulos, Gregory. AU - Ligon, Azra H.. AU - Meyerson, Matthew. AU - Richardson, Andrea L.. AU - Chin, Lynda. AU - Wagner, Gerhard. AU - Asara, John M.. AU - Brugge, Joan S.. AU - Cantley, Lewis C.. AU - Vander Heiden, Matthew G.. PY - 2011/9/1. Y1 - 2011/9/1. N2 - Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood. Using a metabolomics approach with isotope labeling, we found that ...
Two absolutely conserved histidines and a third highly conserved histidine are noted in 11 bacterial and plant ADP-glucose pyrophosphorylases. These histidines were individually mutagenized in the E. coli enzyme to glutamine in order to determine their function. Glutamine mutations at residues 143 and 156 produced functional enzymes in cell extracts with slightly lower than wild-type specific catalytic activities and with same heat stability characteristics of the wild-type enzyme. Substitution of residue 83 with glutamine however produced an enzyme having decreased thermal stability. Additional mutageneses at residue 83 with asparagine, arginine, or aspartate gave rise to enzymes having a progressively decreasing trend in thermal stability. These mutants are more susceptible to proteolysis than wild-type enzyme. Kinetic analysis of H83Q and H83N indicates that histidine 83 is not involved in the catalytic mechanism or in substrate binding but possibly in maintenance of the active catalytic structure.
Now, however, education research and cognitive science have given us deeper insights into the process of learning. c) 3-phosphoglyceric acid. Furthermore, the arts infused classroom has an advantage of using individual learning styles ef- In the same ecosystem, nutrients would cycle between the tree and the giraffe. The Calvin cycle is the cycle of chemical reactions performed by plants to fix carbon from CO 2 into three-carbon sugars.. Later, plants and animals can turn these three-carbon compounds into amino acids, nucleotides, and more complex sugars such as starches.. The giraffe would consume oxygen and release carbon dioxide as its cells perform aerobic respiration to create chemical energy. transfer fixed carbon dioxide to cells in which the Calvin cycle occurs : use malic acid to transfer carbon dioxide to the Calvin cycle : use PEP carboxylase to fix carbon dioxide ©;2005 Pearson Education, Inc., publishing as Benjamin Cummings. the production of carbohydrate molecules from G3P, ...
Previous studies have indicated that ADP-glucose pyrophosphorylase (ADPGlc PPase) from the cyanobacteriumAnabaena sp. strain PCC 7120 is more similar to higher-plant than to enteric bacterial enzymes
The Phosphoglycerate Kinase 1 is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19.PGK1 is distinguished from testicular PGK2, which maps to chromosome 6p21. The deduced protein contains 417 amino acid residues. Southern blot analysis of human genomic DNAs showed a complex pattern of hybridizing fragments, 2 of which were non-X in origin. The results were interpreted as reflecting the existence of a small family of dispersed PGK or PGK-like genes.
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Enolase (2-phospho-D-glycerate hydrolase) is an essential, homodimeric enzyme that catalyses the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways [ (PUBMED:1859865) (PUBMED:1840492) ]. The reaction is facilitated by the presence of metal ions [ (PUBMED:8605183) ]. In vertebrates, there are 3 different, tissue-specific isoenzymes, designated alpha, beta and gamma. Alpha is present in most tissues, beta is localised in muscle tissue, and gamma is found only in nervous tissue. The functional enzyme exists as a dimer of any 2 isoforms. In immature organs and in adult liver, it is usually an alpha homodimer, in adult skeletal muscle, a beta homodimer, and in adult neurons, a gamma homodimer. In developing muscle, it is usually an alpha/beta heterodimer, and in the developing nervous system, an alpha/gamma heterodimer [ (PUBMED:3390159) ]. The tissue specific forms display minor kinetic differences. Tau-crystallin, one of the ...
Recombinant Phosphoglycerate Kinase 2 (PGK2) Protein (His tag). Species: Human. Source: Escherichia coli (E. coli). Order product ABIN1981682.
Phosphoglycerate kinase (PGK) mammalian promoter for constitutive expression. The PGK promoter is upstream of our normal multiple cloning site.
In higher vertebrates, the glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase; EC 4.2.1.11) is active as a dimer formed from three different subunits, α, β and γ, encoded by separate genes. Th
PHGDH antibody [N3C2], Internal (phosphoglycerate dehydrogenase) for IHC-Fr, IHC-P, WB. Anti-PHGDH pAb (GTX101949) is tested in Human, Rat samples. 100% Ab-Assurance.
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018 ...
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018 ...
Pgk1 - Pgk1 (untagged ORF) - Rat phosphoglycerate kinase 1 (Pgk1), (10 ug) available for purchase from OriGene - Your Gene Company.
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3-phosphoglyceric acid (PGA) is the first stable product of dark reaction of photosynthesis and since it is a 3-carbon compound, this cycle is known as C3 cycle.. 2). Reductive phase :. Six molecules of 3PGA are phosphorylated by 6 molecules of ATP (produced in the light reaction) to yield 6 molecules of 1,3-biphosphoglyceric acid and 6 molecules of ADP. This reaction is catalyzed by the enzyme, Kinase.. Six molecules of 1, 3 bisphosphoglyceric acid are reduced with the use of 6 molecules of NADPH2 (produced in light reaction) to form 6 molecules of 3- phospho glyceraldehyde. This reaction is catalysed by the enzyme, triose phosphate dehydrogenase.. 3). Regenerative phase :. In the regenerative phase, the ribose biphosphate is regenerated. The regenerative phase is called as pentose phosphate pathway or hexose monophophate shunt.. It involves the following steps :. i). Some of the molecules of 3-phosphoglyceraldehyde into dihydroxyacetone phosphate in the presence of enzyme triose phosphate ...
2019年10月10日,上海交通大學醫學院藥理學與化學生物學系沈瑛副研究員課題組聯合復旦大學藥學院周璐副教授和上海中醫藥大學陳紅專教授在Cell Metabolism 雜志發表長文A novel allosteric inhibitor of phosphoglycerate mutase 1 suppresses growth and metastasis of non-small cell lung cancer,率先報道磷酸甘油酸變位酶1(phosphoglycerate mutase 1, PGAM1)新型別構抑制劑對非小細胞肺癌的增殖、耐藥和轉移等生物學活性的多重抑制作用,揭示通過別構調節PGAM1同時干預PGAM1的代謝酶活性和非代謝酶依賴的蛋白-蛋白相互作用的抗腫瘤藥理學新機制。 ...
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015 ...
The PGTC Center, directed by Dr. Barry Byrne, was founded in 1996. Its primary mission is to merge molecular genetics research and health care delivery by developing new therapeutic strategies for the treatment of human diseases that involve gene transfer. The PGTC was recently named one of only two National Gene Vector Laboratory (NGVL) Toxicology Centers by the NCRR and was also selected by the NCRR as the site for production of the National Reference Standard Stock of AAV, to set the standard for the potency and purity of these key gene transfer reagents and to allow for greater sharing of data among various centers. The PGTC has been awarded 4 NIH program project grants totaling approximately $25 M to pursue gene therapy for diseases of the heart, lungs, and liver and has been designated as a Diabetes Gene Therapy Center by the Juvenile Diabetes Research Foundation. The PGTC has pioneered several advances relevant to gene delivery including discovery of the unique life cycle of AAV; first ...
testis specific phosphoglycerate kinase: human testis-specific isoenzyme; amino acid sequence in first source; RefSeq NM_138733 (human), NM_031190 (mouse); GenBank AY496962 and AY500132 (S scrofa)
The SCOP classification for the Phosphoglycerate kinase superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
K01834 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] , (GenBank) gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate ...
Phosphoglycerate kinase (EC 2.7.2.3)(PGK) catalyzes the second step in the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. It is a two-domain protein; each domain is composed of six repeats of an alpha/beta structural motif ...
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Learn about Phosphoglycerate Kinase Deficiency and other health conditions at HealtheTreatment. What is Phosphoglycerate Kinase Deficiency? Compare Phosphoglycerate Kinase Deficiency symptoms Phosphoglycerate Kinase Deficiency treatments and . Share online in the health community.
Proliferating cells, including cancer cells, obtain serine both exogenously and via the metabolism of glucose. By catalyzing the first, rate-limiting step in the synthesis of serine from glucose, phosphoglycerate dehydrogenase (PHGDH) controls flux through the biosynthetic pathway for this important amino acid and represents a putative target in oncology. To discover inhibitors of PHGDH, a coupled biochemical assay was developed and optimized to enable high-throughput screening for inhibitors of human PHGDH. Feedback inhibition was minimized by coupling PHGDH activity to two downstream enzymes (PSAT1 and PSPH), providing a marked improvement in enzymatic turnover. Further coupling of NADH to a diaphorase/resazurin system enabled a red-shifted detection readout, minimizing interference due to compound autofluorescence. With this protocol, over 400,000 small molecules were screened for PHGDH inhibition, and following hit validation and triage work, a piperazine-1-thiourea was identified. Following ...
At least five mutations in the PGAM2 gene have been found to cause phosphoglycerate mutase deficiency. The most common of these mutations, written as Trp78Ter or W78X, replaces the protein building block (amino acid) tryptophan with a premature stop signal in the instructions for making phosphoglycerate mutase. This mutation results in the production of an abnormally short, nonfunctional version of the enzyme. Other mutations change single amino acids in phosphoglycerate mutase.. Mutations in the PGAM2 gene greatly reduce the activity of phosphoglycerate mutase, which disrupts energy production in skeletal muscle cells. This defect underlies the muscle cramping, muscle breakdown, and related signs and symptoms that occur following strenuous exercise in affected individuals. ...
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The mouse autosomal locus that determines the form of phosphoglycerate kinase found only in testes is shown here to be closely linked to but not included within the major histocompatibility complex on chromosome 17. Data are presented that strongly favor the location of this locus, designated Pgk-2, distal to H-2, Qa-1, and Qa-2, and closely associated with T1a. The Pgk-2 strain distribution pattern for 103 inbred and congenic strains of mice is given. Because Pgk-2 is polymorphic among inbred strains, it should be of value in linkage studies.
Top performende anti-Yeast (Saccharomyces cerevisiae) Phosphoglycerate Kinase 1 Antikörper für Immunofluorescence (IF) vergleichen & kaufen.
GT:ID BAD56223.1 GT:GENE BAD56223.1 GT:PRODUCT putative phosphoglycerate mutase GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION 1542838..1543497 GB:FROM 1542838 GB:TO 1543497 GB:DIRECTION + GB:PRODUCT putative phosphoglycerate mutase GB:PROTEIN_ID BAD56223.1 LENGTH 219 SQ:AASEQ MSKYAGVRTLILLRHGQTEWNATDRMQGQIDTDLTELGRRQAKEAARELVSRNAIAIVSSDLRRAHDTALALAEHTDVPVALDPRLRETHLGDWQGLTHLEVDADYPGARVAWRLDATYRPPGGESKLEVGARALPVVRELYNERQDWPGRTIILVAHGGLIAALTAALLELPPQNWPALGGLANTSWVQLSSHGPGIDQPGWRLDVWNAAAKVAPDVL GT:EXON 1,1-219:0, BL:SWS:NREP 1 BL:SWS:REP 8-,136,GPMA_NITWN,4e-19,42.6,129/207, PROS 12-,21,PS00175,PG_MUTASE,PDOC00158, SEG 157-,172,ahggliaaltaallel, BL:PDB:NREP 1 BL:PDB:REP 9-,156,1h2eA,2e-22,40.0,145/207, RP:PDB:NREP 1 RP:PDB:REP 8-,209,1ebbA,8e-30,32.0,194/202, RP:PFM:NREP 1 RP:PFM:REP 10-,156,PF00300,2e-23,45.8,144/158,PGAM, HM:PFM:NREP 1 HM:PFM:REP 9-,165,PF00300,3.7e-45,40.0,155/158,PGAM, RP:SCP:NREP 1 RP:SCP:REP 8-,209,1ebbA,3e-30,32.0,194/202,c.60.1.1, HM:SCP:REP ...
Pgam2 - Pgam2 (Myc-DDK-tagged ORF) - Rat phosphoglycerate mutase 2 (muscle) (Pgam2), (10 ug) available for purchase from OriGene - Your Gene Company.
Höhner, R.; Day, P. M.; Zimmermann, S. E.; Lopez, L. S.; Krämer, M.; Giavalisco, P.; Correa Galvis, V.; Armbruster, U.; Schöttler, M. A.; Jahns, P. et al.; Krüger, S.; Kunz, H.-H.: Stromal NADH supplied by PHOSPHOGLYCERATE DEHYDROGENASE3 is crucial for photosynthetic performance. Plant Physiology 186 (1), S. 142 - 167 (2021 ...
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