GAPDHS (the sperm-specific glyceraldehyde phosphate dehydrogenase, also known as GAPD2, GAPDS, HSD-35, or GAPDH-2, is a glycolytic enzyme that plays an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. It can be used as an intra-acrosomal marker for evaluation of the physiological state of sperm cells as well as for selection of a suitable method of fertilization in the laboratories of assisted reproduction ...
Cloning and Sequence Analysis of Glyceraldehyde-3-Phosphate Dehydrogenase Gene in Yak - Yak;Glyceraldehyde-3-Phosphate Dehydrogenase gene;Cloning;Housekeeping Gene;
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) is a conserved protein found in higher plants. In photosynthetic cells, the enzyme is involved in a shuttle transfer mechanism to export NADPH from the chloroplast to the cytosol. In this work, we demonstrate that GAPN gene express in leaves and roots at similar levels; showing the highest level of expression in flowers. To investigate the role of this enzyme in different plant tissues, we characterized a mutant from Arabidopsis thaliana having an insertion at the GAPN gene locus. The homozygous mutant was determined to be null respect to GAPN, as it exhibited complete absence of both expression of GAPN mRNA and enzyme activity. Transcriptome analysis demonstrated that the insertion mutant plant shows altered expression of several enzymes involved in carbohydrate metabolism. Significantly, cytosolic phosphorylating (NAD-dependent) glyceraldehyde-3-phosphate dehydrogenase mRNA levels are induced in the mutant, which correlates with an
Buy our Recombinant human GAPDH protein. Ab82633 is an active full length protein produced in Escherichia coli and has been validated in WB, SDS-PAGE. Abcam…
Glucose in the bloodstream diffuses into the cytoplasm and is locked there by phosphorylation. A glucose molecule is then rearranged slightly to fructose and phosphorylated again to fructose diphosphate. These steps actually require energy, in the form of two ATPs per glucose. The fructose is then cleaved to yield two glyceraldehyde phosphates (GPs). In the next steps, energy is finally released, in the form of two ATPs and two NADHs, as the GPs are oxidized to phosphoglycerates. One of the key enzymes in this process is glyceraldehyde phosphate dehydrogenase (GPDH), which transfers a hydrogen atom from the GP to NAD to yield the energetic NADH. Due to its key position in the glycolytic pathway, biochemical assays of GPDH are often used to estimate the glycolytic capacity of a muscle cell. Finally, two more ATPs are produced as the phosphoglycerates are oxidized to pyruvate.varicofix pret. ...
Reminiscent of mild-mannered Clark Kent, the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has an alter ego with potent and deadly effects. When translocated to the nucleus, GAPDH has been associated with transcriptional regulation, and Hara et al. present results implicating it in control of apoptosis. A yeast two-hybrid screen for proteins interacting with GAPDH turned up Siah1, an E3 ubiquitin ligase. In transfected cells, the authors detected interaction of the proteins and increased localization of GAPDH to the nucleus, an effect that required the nuclear localization signal of Siah1. In human embryonic kidney cells undergoing apoptosis in response to staurosporine, the authors detected modification of GAPDH by mass spectrometry and went on to show in vitro that modification of GAPDH by S-nitrosylation (often a consequence of increased generation of nitric oxide within cells) enhanced association with Siah1. These events appear to be important in regulation of ...
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.
Aging and skeletal muscle ischemia/reperfusion (I/R) injury both lead to skeletal\r\nmuscle dysfunction, evidenced by decreased contractile force generation, particularly in\r\nglycolytic muscle. The deficits in I/R are more severe and persistent in aged animals.\r\nPrevious studies in our lab led us to hypothesize that the expression of the glycolytic\r\nenzyme glyceraldehyde-3-phosphate dehydrogenase may be altered following I/R. We\r\nfurther hypothesized that aging would enhance the oxidative stress and oxidative damage\r\nexperienced by the muscle. GAPDH protein levels were measured by Western blotting.\r\nWe observed that the enzyme is significantly decreased at 3 and 5 days of reperfusion in\r\nthe young muscle, while the enzyme was significantly decreased in the aged muscle at 1,\r\n3, 5, and 7 days. Using PCR, we compared GAPDH mRNA levels at 5 days reperfusion\r\nand found that the I/R tissue from both young and old have significant increases in\r\nGAPDH transcript at this time point ...
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Lactoferrin is a crucial nutritionally important pleiotropic molecule and iron an essential trace metal for all life. The current paradigm is that living organisms have evolved specific membrane anchored receptors along with iron carrier molecules for regulated absorption, transport, storage and mobilization of these vital nutrients. We present evidence for the existence of non-canonical pathway whereby cells actively forage these vital resources from beyond their physical boundaries, by secreting the multifunctional housekeeping enzyme Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) into the extracellular milieu. This effects an autocrine/paracrine acquisition of target ligand into the cell. Internalization by this route is extensively favoured even by cells that express surface receptors for lactoferrin and involves urokinase plasminogen activator receptor (uPAR). We also demonstrate the operation of this phenomenon during inflammation, as an arm of the innate immune response where ...
Glyceraldehyde-3-phosphate dehydrogenase gene over expression correlates with poor prognosis in non small cell lung cancer patients. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in ...
siSTABLE GAPD Control siRNA is a validated positive control, guaranteed to silence GAPD in mouse cells. This control siRNA is chemically modified to significantly extend siRNA stability and is recommended for use as a positive control in experiments using siSTABLE modified siRNA against a target gene or where increased stability of the control is desired.. Also known as glyceraldehyde-3-phosphate dehydrogenase or GAPDH, GAPD is an important enzyme in carbohydrate metabolism that is well conserved across the animal kingdom. This gene is abundantly expressed in most cells, and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. Targets accession number NM_001001303.. ...
... is a validated positive control, guaranteed to silence GAPD in human cells. siGENOME siRNA positive control designs are highly functional, chemically synthesized and mostly unmodified siRNA duplexes that allow positive silencing for validation of experimental design and detection methodologies.. Also known as glyceraldehyde-3-phosphate dehydrogenase or GAPDH, GAPD is an important enzyme in carbohydrate metabolism that is well conserved across the animal kingdom. This gene is abundantly expressed in most cells and because it is non-essential, knockdown of the corresponding mRNA does not affect cell viability. ...
This study functionally characterizes the Arabidopsis (Arabidopsis thaliana) plastidial glycolytic isoforms of glyceraldehyde-3-phosphate dehydrogenase (GAPCp) in photosynthetic and heterotrophic cells. We expressed the enzyme in gapcp double mutants (gapcp1gapcp2) under the control of photosynthetic (Rubisco small subunit RBCS2B [RBCS]) or heterotrophic (phosphate transporter PHT1.2 [PHT]) cell-specific promoters. Expression of GAPCp1 under the control of RBCS in gapcp1gapcp2 had no significant effect on the metabolite profile or growth in the aerial part (AP). GAPCp1 expression under the control of the PHT promoter clearly affected Arabidopsis development by increasing the number of lateral roots and having a major effect on AP growth and metabolite profile. Our results indicate that GAPCp1 is not functionally important in photosynthetic cells but plays a fundamental role in roots and in heterotrophic cells of the AP. Specifically, GAPCp activity may be required in root meristems and the root ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Sperm proteins are important for the sperm cell function in fertilization. Some of them are involved in the binding of sperm to the egg. We characterized the acrosomal sperm protein detected by a monoclonal antibody (MoAb) (Hs-8) that was prepared in our laboratory by immunization of BALB/c mice with human ejaculated sperms and we tested the possible role of this protein in the binding assay. Indirect immunofluorescence and immunogold labelling, gel electrophoresis, Western blotting and protein sequencing were used for Hs-8 antigen characterization. Functional analysis of GAPDHS from the sperm acrosome was performed in the boar model using sperm/zona pellucida binding assay. Monoclonal antibody Hs-8 is an anti-human sperm antibody that cross-reacts with the Hs-8-related protein in spermatozoa of other mammalian species (boar, mouse). In the immunofluorescence test, Hs-8 antibody recognized the protein localized in the acrosomal part of the sperm head and in the principal piece of the sperm flagellum. In
Featured HRP Conjugated Anti-GAPDH Mouse Monoclonal Antibody (2B5) , specially designed for your immunoassay as internal control.,GAPDH; GAPD; CDABP0047; OK/SW-cl.12; Glyceraldehyde-3-phosphate dehydrogenase; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH,Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or less commonly as G3PDH) is an enzyme of ~37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis ER to Golgi vesicle shuttling, and fast axonal, or axoplasmic transport.
1NQA: Crystal structure of two ternary complexes of phosphorylating Glyceraldehyde-3-Phosphate Dehydrogenase from Bacillus stearothermophilus with NAD and D-Glyceraldehyde-3-Phosphate
Synonyms for glucose-6-phosphate dehydrogenase (G6PD) in Free Thesaurus. Antonyms for glucose-6-phosphate dehydrogenase (G6PD). 8 words related to glucose: aldohexose, glucosamine, corn sugar, dextroglucose, dextrose, grape sugar, blood glucose, blood sugar. What are synonyms for glucose-6-phosphate dehydrogenase (G6PD)?
28S-ribosomal RNA is superior to glyceraldehyde-3-phosphate dehydrogenase as a RNA reference gene in p53-deficient mice with unilateral ureteral obstruction Academic Article ...
Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or less commonly as G3PDH) (EC 1.2.1.12) is an enzyme of ~37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis, ER to Golgi vesicle shuttling, and fast axonal, or axoplasmic transport. In sperm, a testis-specific isoenzyme GAPDHS is expressed. Under normal cellular conditions, cytoplasmic GAPDH exists primarily as a tetramer. This form is composed of four identical 37-kDa subunits containing a single catalytic thiol group each and critical to the enzymes catalytic function. Nuclear GAPDH has increased isoelectric point (pI) of pH 8.3-8.7. Of note, the cysteine residue C152 in the enzymes active site is required for the induction of apoptosis by oxidative stress. Notably, ...
The main result of this study was that GAPDH activity was decreased in embryos subjected to a teratogenic diabetic environment in vivo (maternal diabetes) or diabetes-like environment in vitro (increased glucose concentration). When the disturbed embryonic development in vitro was corrected by the addition of the antioxidant NAC to the culture medium with high glucose concentration, GAPDH activity increased toward normal values. This strongly suggests the existence of common ROS-associated elements in the pathogenesis of glucose-induced congenital malformations and glucose-induced inhibition of embryonic GAPDH activity.. To probe the relation among glucose-induced embryonic maldevelopment, GAPDH inhibition, and ROS excess, we removed the glucose challenge by directly inhibiting GAPDH with IA. We found that IA supplementation to the culture medium yielded embryonic maldevelopment similar to the glucose-induced dysmorphogenesis and, furthermore, that the addition of NAC diminished both the GAPDH ...
VARIANTS OF THE PROMOTER OF THE GAP GENE CODING FOR GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE - diagram, schematic, and image 47 ...
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a key role in vascular homeostasis by modulating expression levels of the vasoconstrictor endothelin-1 (ET-1). Elevated ET-1 levels are associated with vascular diseases, and ET-1 expression is tightly regulated via GAPDH-mediated destabilization of its mRNA. Recent studies suggest GAPDH binding of adenine-uridine rich elements (AREs) in the 3-untranslated region (3-UTR) of the ET-1 gene leads to decreased mRNA stability. However, structural and mechanistic details underlying the GAPDH-mediated control of ET-1 expression are lacking. We sought to elucidate the structural and mechanistic details for the GAPDH-induced destabilization of ET-1 mRNA via electrophoretic mobility shift assay (EMSA), isothermal titration calorimetry (ITC), and x-ray crystallography. To identify specific GAPDH binding sequences, we constructed short RNA transcripts of the putative mRNA binding region. Utilizing ITC and EMSA, we obtained dissociation constants. We ...
1JN0: Crystal structure of the non-regulatory A(4 )isoform of spinach chloroplast glyceraldehyde-3-phosphate dehydrogenase complexed with NADP.
Product Name: Mouse mAb anti- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Clone H8Collection: AntibodySub Category: Monoclonal AntibodyImmunogen:
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|strong|Mouse anti Human GAPDH antibody, clone 4G5|/strong| recognizes glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a 36 kDa protein whose main function is to catalyse the reversible oxidative ph…
Complete information for GAPDH gene (Protein Coding), Glyceraldehyde-3-Phosphate Dehydrogenase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
GAPB (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE B SUBUNIT); glyceraldehyde-3-phosphate dehydrogenase (NADP+)/ glyceraldehyde-3-phosphate dehydrogenase ...
(= GAPD; GAPDH; G3PD) Glycolytic enzyme (EC 1.2.1.12) that catalyses the reversible oxidative phosphorylation of glyceraldehyde 3 phosphate. Has been shown to interact with various elements of the cytoskeleton, and with the trinucleotide repeat…
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GAPDH - GAPDH (untagged)-Human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) available for purchase from OriGene - Your Gene Company.
TY - JOUR. T1 - Glucose-6-phosphate dehydrogenase (G6PD). Response of the human erythrocyte and another cells to the decrease in their activity. AU - Bonilla, Javier Fernando. AU - Sánchez, Magna Carolina. AU - Chuaire, Lilian. PY - 2007/1/1. Y1 - 2007/1/1. N2 - Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis, G6PDH deficiency is the most common X-chromosome-linked enzymopathy in human beings. Although it is present in any type cell, its absolute deficiency is incompatible with life. According to WHO, 400 million people are affected by G6PD deficiency in the world but in Colombia, the severe form prevalence is about 3% to 7%. There are no data related to slight and moderate ...
The Apoptosis and DNA Damage (H2A.X(S139) + cleaved PARP1 + Anti-GAPDH) Western Blot Cocktail (ab131385) is designed to study the induction of DNA damage and/or apoptosis in response to various s…
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The NAD+-dependent glyceraldehyde-3-phosphate-dehydrogenase (NAD+-GAPDH) is a key enzyme to sustain the glycolytic function in Escherichia coli and to generate NADH. In the absence of NAD+-GAPDH activ
Gentaur molecular products has all kinds of products like :search , Alpha Dia \ Anti_Rabbit muscle Glyceraldehyde_3_Phosphate Dehydrogenase G3PDH IgG 2 \ G3PDH12-S for more molecular products just contact us
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins. [-] ...
im running qPCR on two cell lines (equine oral and limb fibroblasts) treated with various treatments. i have run all treatments for each cell line with my GAPDH primers and examination of the delta c(t) for each separate cell line indicates that GAPDH expression is not affected by treatment but when you put the data for both sets of cell lines together, there is a significant change in expression between the two. ie, expression of GAPDH is not altered by treatment in either of the cell lines, but it is expressed at different ...
Serum testosterone levels were evaluated at day 7 in each group using a RIA kit (Orion Diagnostica Finland). MS in Galapagos bio-analytical department. Ostarine Useless total RNA was treated with DNase I (Ambion Inc.. A: MMRM analysis through Day 84 visit; FIG. B: MMRM analysis through Day 147 visit. Day 84 visit; FIG.. Colorectal 21 (40. Mean (SD) weight -8. Mean (SD) LBM kg ,img Ostarine Useless src=http://media4.popsugar-assets.com/files/2015/08/17/119/n/4852708/0203c3bf48ff956a_2cjcJi0.xxxlarge/i/Health-Fitness-Instagram-Photos-Motivation.jpg alt=Ostarine Useless,. 47.. Real time quantitative PCR (RT-QPCR) assays were performed using an Applied Biosystems ViiA7 sequence detector. GAPDH transcript was used as an internal control to normalize the variations for RNA amounts. Gene expression levels are buy sarms manufacturers expressed relative to GAPDH mRNA levels.. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers. This randomized double-blind ...
M. ANWAR GOHEER, BARRY J. GOULD, DENNIS V. PARKE; The Effects of pH and Temperature on Covalently Immobilized Glucose 6-Phosphate Dehydrogenase. Biochem Soc Trans 1 November 1973; 1 (6): 1282-1284. doi: https://doi.org/10.1042/bst0011282. Download citation file:. ...
Mouse Monoclonal Anti-Glucose 6 Phosphate Dehydrogenase Antibody (3H5). Cytosol Marker. Validated: WB, ELISA. Tested Reactivity: Human. 100% Guaranteed.
Glucose 6 Phosphate Dehydrogenase兔多克隆抗体(ab993)可与小鼠, 大鼠, 人样本反应并经WB, IP, IHC, ICC/IF实验严格验证,被8篇文献引用并得到10个独立的用户反馈。
ウサギ・ポリクローナル抗体 ab22555 交差種: Ms,Rat,Hu,Bb 適用: WB,ICC/IF…GAPDH抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。
Complete information for GPD1 gene (Protein Coding), Glycerol-3-Phosphate Dehydrogenase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
GeneAmp RNA PCR core kit와 PTC-200(MJ Research Inc., Watertown, MA, USA) PCR machine을 사용하여 제조사의 방법대로 시행하였다. PCR에 사용된 oligonucleotideprimer는 밝혀진 염기서열에 의해 제작하였으며, 각 반응의 내부 양성 대조군(internal positive control)은 glyceraldehyde-3-phosphate dehydrogenase(GAPDH)를 사용하였다. 실험에 사용된 primer의 염기배열은 MUC5B의 경우 sense는 5-CAC ATC CAC CCT TCC AAC-3, antisense는 5-GGC TCA TTG TCG TCT CTG-3이고, TLR4의 경우 sense는 5-ACA ACC TCC CCT TCT CAA CC-3, antisense는 5-AAC TCT GGA TGG GGT TTC CT-3이며, GAPDH의 경우 sense는 5-CCT CCA AGG AGT AAG ACC CC-3, antisense는 5-AGG GGT CTA CAT GGC AAC TG-3을 사용하였다. 증폭된 mRNA 산물의 크기는 MUC5B는 245 bp, TLR4는 201 bp, GAPDH는 145 bp였다. 과정을 간략히 설명하면, 배양된 세포를 2% bovine serum albumin을 함유한 phosphate buffered saline(PBS)로 3회 세척한 후 ...
The funny thing is that tumor cells are known for increased glucose metabolism, not only increased glucose consumption but anaerobic glucose metabolism, which is much less efficient. So wouldnt these cells just starve to death? I guess they would, if the increase in the metabolic flux where in the ATP consuming steps, what would lead to accumulation of metabolites and energy deprivation. But if the increase is in the ATP generating steps (after glyceraldehyde-3-phosphate dehydrogenase) then it would yield to energy surplus ...
Glucose-6-phosphatase dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans, affecting 400 million people worldwide. It has a high prevalence in persons of African, Asian, and Mediterranean descent.