TY - JOUR. T1 - 3D porous chitosan-alginate scaffolds. T2 - A new matrix for studying prostate cancer cell-lymphocyte interactions in vitro. AU - Florczyk, Stephen J.. AU - Liu, Gang. AU - Kievit, Forrest M.. AU - Lewis, Allison M.. AU - Wu, Jennifer D.. AU - Zhang, Miqin. PY - 2012/9/1. Y1 - 2012/9/1. N2 - The treatment of castration-resistant prostate cancer (CRPC) remains palliative. Immunotherapy offers a potentially effective therapy for CRPC; however, its advancement into the clinic has been slow, in part because of the lack of representative in vitro tumor models that resemble the in vivo tumor microenvironment for studying interactions of CRPC cells with immune cells and other potential therapeutics. This study evaluates the use of 3D porous chitosan-alginate (CA) scaffolds for culturing human prostate cancer (PCa) cells and studying tumor cell interaction with human peripheral blood lymphocytes (PBLs) ex vivo. CA scaffolds and Matrigel matrix samples support in vitro tumor spheroid ...

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4-O-Substituted D-glucuronic acid derivatives were synthesized from D-glucose in order to study the regioselectivity of sulfation.

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Grape juice can be easily contaminated with ochratoxin A (OTA), one of the known mycotoxins with the greatest public health significance. Among the different approaches to decontaminate juice from this mycotoxin, microbiological methods proved efficient, inexpensive and safe, particularly the use of yeast or yeast products. To ascertain whether immobilisation of the yeast biomass would lead to successful decontamination, alginate beads encapsulating Candida intermedia yeast cells were used in our experiments to evaluate their OTA-biosorption efficacy. Magnetic calcium alginate beads were also prepared by adding magnetite in the formulation to allow fast removal from the aqueous solution with a magnet. Calcium alginate beads were added to commercial grape juice spiked with 20μg/kg OTA and after 48h of incubation a significant reduction (,80%), of the total OTA content was achieved, while in the subsequent phases (72-120h) OTA was slowly released into the grape juice by alginate beads. ...

Calcium alginate is a water-insoluble, gelatinous, cream-coloured substance that can be created through the addition of aqueous calcium chloride to aqueous sodium alginate. Calcium alginate is also used for entrapment of enzymes and forming artificial seeds in plant tissue culture. Alginate is usually the salts of alginic acid, but it can also refer to derivatives of alginic acid and alginic acid itself; in some publications the term algin is used instead of alginate. Alginate is present in the cell walls of brown algae, as the calcium, magnesium and sodium salts of alginic acid. To extract the alginate, the seaweed is broken into pieces and stirred with a hot solution of an alkali, usually sodium carbonate. Over a period of about two hours, the alginate dissolves as sodium alginate to give a very thick slurry. This slurry also contains the part of the seaweed that does not dissolve, mainly cellulose. This insoluble residue must be removed from the solution. The solution is too thick ...

TY - JOUR. T1 - The effect of sodium alginate on physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer. AU - Kim, Min Soo. AU - Kim, Jeong Soo. AU - Hwang, Sung Joo. PY - 2007/11/1. Y1 - 2007/11/1. N2 - The aim of this study was to investigate the effect of sodium alginate on the physical and dissolution properties of Surelease®-matrix pellets prepared by a novel pelletizer-equipped piston extruder and double-arm counter-rotating rollers. The mean values of the shape factor (eR) and the aspect ratio of Surelease®-matrix pellets were 0.615-0.625 and 1.06-1.070, respectively, indicating good sphericity of the pellets. The drug release rate increased as the amount of sodium alginate increased due to hydration, swelling, and erosion within the Surelease®-matrix pellets. In addition, the porosity of pellets also increased with increasing sodium alginate content. The results of this study show that sodium alginate has a greater effect on the drug release ...

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There have been few studies of the effect of alginate dressings on the processes of wound healing.. The healing of cutaneous ulcers requires the development of a vascularized granular tissue bed, filling of large tissue defects by dermal regeneration, and the restoration of a continuous epidermal keratinocyte layer. These processes were modeled in vitro in one study, utilizing human dermal fibroblast, microvascular endothelial cell (HMEC), and keratinocyte cultures to examine the effect of calcium alginate on the proliferation and motility of these cultures, and the formation of capillarylike structures by HMEC.. In the study, the calcium alginate increased the proliferation of fibroblasts but decreased the proliferation of HMEC and keratinocytes. In contrast, the calcium alginate decreased fibroblast motility but had no effect on keratinocyte motility. There was no significant effect of calcium alginate on the formation of capillarylike structures by HMEC. The effects of calcium alginate on ...

Like many natural polysaccharides, dried alginates are not stable to heat, oxygen, metallic ions, etc. Stored in such circumstances, alginates will be degraded naturally. The high-viscosity alginate is more rapidly degraded than the medium-or low- viscosity ones. The order of stability in storage is: sodium alginate , ammonium alginate , alginic acid.. Different kind of alginate salt gives different stability, so does the different grade product. The industrial grade alginate solution is more easily degraded by microbe in the air, because such products contain much algal particles and nitrogenous matter which offer plenty of nutrition for microbe. The pure sodium alginate solution can be kept at room temperature for several months without obvious change in viscosity. When temperature increases, all alginate solutions will depolymerize. Alginate solutions are stable in the pH range 5.5 - 10 at room temperature for a long time, but will form the gel below pH 5.5. Propylene glycol alginate solution ...

The two-phase model used previously to calculate the polymer-subphase volume of alginic acid was applied to interpret the dependence of apparent metal binding equilibrium on environmental conditions. In this model, the polymer subphase, a small aqueous region surrounding the polymer chain, was considered as a separate phase in the aqueous solution and as a protonation-deprotonation and metal binding reaction zone. Three factors were taken into account when treating experimental data: (1) the electric field due to the charged ligands on the polymer molecule, (2) the effective concentration of ligands based on polymer-subphase volume, and (3) the competition from hydrogen ions for the metal binding sites. The data of base titration of alginic acid in the presence of trace amounts of copper at different alginic acid concentrations and ionic strengths yielded unique intrinsic stability constants for complexes formed between a cupric ion and one or two binding ligands ...

Press Release issued Apr 30, 2019: There are several types of alginates available in the global market including sodium, calcium, and potassium out of which sodium alginates hold the highest share of the market. Sodium alginate is a type of natural polysaccharide which is extracted from the brown seaweed that grows in cold water regions. Sodium alginate market is expanding mainly on account of the increasing size of food industry. Sodium alginate is soluble in cold and hot water, and possesses thickening and binding properties. Sodium alginate forms a gel without being heated in the presence of calcium. Sodium alginate is generally used along with calcium salts in several cuisines to produce small and large spheres filled with liquid that burst in the mouth. Sodium Alginate is also used in the food industry as an emulsifier to increase viscosity. It is also used in indigestion tablets as it does not have any discernible flavor.

This study explores the utility of calcium-alginate hydrogels as a three-dimensional culture platform for hematopoietic cell culture. We investigate the effects of calcium concentration and alginate viscosity on the mechanical and physical properties of the gel, and their subsequent effects on cellular growth. Further, we have also explored the establishment of a co-culture system in the presence of stromal cells (HS-5) and using K562 cells as our hematopoietic model. Physical characterization of calcium alginate is conducted with mechanical testing and Scanning Electron Microscope (SEM) scans to determine the relationship between the mechanical strength and the structure of calcium alginate with the variation of calcium concentration and alginate viscosity. The study on mechanical properties via compressive stress test reveals that increasing calcium concentration and alginate viscosity resulted in the formation of stiffer gels as showed by the higher elastic moduli. In addition, SEM scans ...

The high cost of soluble enzymes can limit their use for commercial and industrial purposes. Immobilization can enhance enzyme reusability, thereby reducing product isolation costs and overcoming this economic barrier. In the current study, two novel, purified lipases from Pseudomonas sp. (Pseudomonas reinekei and Pseudomonas brenneri) were entrapped in a calcium alginate matrix, with the aim of simultaneously enhancing enzyme reusability and stability. Following entrapment, the retained activity of the enzyme-alginate composite was verified by an enzymatic hydrolysis reaction of a p-nitrophenol palmitate substrate. The effect of the enzyme-alginate entrapment against various physiochemical parameters such as pH, temperature, metal ions, and solvents were subsequently examined. The entrapment was found to have minimal beneficial stability gains. However, enhanced enzyme reusability (up to 3 cycles) and stability (up to 18 days at 4°C) of the calcium alginate entrapped lipase, as indicated by

Sodium Alginate Market by Product (Food Grade Sodium Alginate, Pharmaceutical Grade Sodium Alginate, Technical Grade Sodium Alginate, Feed Grade Sodium Alginate), by Application (Food Additives, Pharmaceutical & Healthcare, Paper & Pulp, Personal Care & Cosmetics, Textile, Animal Feed, Industrial) and by Region, Trend, Forecast, Competitive Analysis, and Growth Opportunity 2019-2024 - Radiant Insights

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The influence of the mixture of water and alcohols on the solubility and properties of alginate and its calcium-induced gels is of interest for the food, wound care and pharmaceutical industries. The solvent quality of water with increasing amounts of ethanol (0-20%) on alginate was studied using intrinsic viscosity. The effect of ethanol addition on the rheological and mechanical properties of calcium alginate gels was determined. Small-angle X-ray scattering and transmission electron microscopy were used to study the network structure. It is shown that the addition of ethanol up to 15% (wt) increases the extension of the alginate chain, which correlates with increased moduli and stress being required to fracture the gels. The extension of the polymer chain is reduced at 20% (wt) ethanol, which is followed by reduced moduli and stress at breakage of the gels. The network structure of gels at high ethanol concentrations (24%) is characterized by thick and poorly connected network strands.. ...

Alginic acid, also called algin or alginate, is an anionic polysaccharide distributed widely in the cell walls of brown algae, where through binding with water it forms a viscous gum. It is also a significant component of the biofilms produced by the bacterium Pseudomonas aeruginosa, the major pathogen in cystic fibrosis, that confer it a high resistance to antibiotics and killing by macrophages. Its colour ranges from white to yellowish-brown. It is sold in filamentous, granular or powdered forms. Alginic acid is a linear copolymer with homopolymeric blocks of (1-4)-linked β-D-mannuronate (M) and its C-5 epimer α-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks) or alternating M and G-residues (MG-blocks). Alginates are refined from brown seaweeds. A wide variety of brown seaweeds of the phylum Phaeophyceae are harvested ...

Figure 1, a) 3D pore 100 µm droplet chip junction, b) 80 µm, c) 100 µm alginate beads.. The Dolomite Team is using microfluidics to produce small (80-120 µm) alginate beads suitable for cell encapsulation. A 2 % alginate solution was dissolved in water overnight with subsequent addition of Ca-EDTA. For the oil phase, 1 % Fluosurf in HFE 7500 was used with 0.05 % acetic acid to release the chelated calcium in the Ca-EDTA complex and allow alginate crosslinking from within. Both solutions were introduced into a 100 µm 3D pore fluorophilic single junction chip (figure 1a) to form spherical monodispersed beads. Depending on flow rates (Qd 16 µlmin-1 Qc 10 µlmin-1 and Qd 10 µlmin-1 Qc 18 µlmin-1) 80 µm (figure 1b) and 100 µm (figure 1c) alginate beads were produced respectively.. DOWNLOAD APPLICATION NOTE HERE. If you are interested in producing alginate beads for your applications, please contact us at [email protected], and keep an eye out for our alginate bead application ...

Alginate is a biodegradable, immunocompatible biopolymer that is capable of immobilizing viable cells and bioactive factors. Few investigations have analyzed the efficacy of alginate gels as substrata for cell attachment and proliferation. Here we have compared the adhesion and subsequent growth of human and rat bone marrow stromal fibroblastic cells on unmodified alginate hydrogel surfaces. It was found that, in contrast to rat cells, human cells did not readily attach or proliferate on unmodified alginates. In attempts to enhance these features, or collagen type I was incorporated into the gels, with no significant improvements in prolonged human cell adherence. However, alginate gels containing both collagen type I and beta-tricalcium phosphate were found to enhance human cell adherence and proliferation. Furthermore, interactions between the collagen and beta-tricalcium phosphate prevented loss of the protein from the hydrogels. These results indicate that alginate gels containing collagen have

The report on the Global Sodium Alginate market offers complete data on the Sodium Alginate market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the Sodium Alginate market. The top contenders SNP, KIMICA, SNAP Natural & Alginate Products, IRO Alginate Industry, NovaMatrix, Bright Moon Seaweed, Lianyungang Tiantian Seaweed Industrial, Unikem of the global Sodium Alginate market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=19657. The report also segments the global Sodium Alginate market based on product mode and segmentation Industrial Grade, Food Grade, Pharma Grade. The study includes a profound summary of the key sectors and the segments Papermaking, Paper Coatings, Textiles, Food & ...

Alginate is used in various pharmaceutical preparations. Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Alginic acid can be separated from benzoate, citric acid and saccharin by mixed-mode chromatography on Primesep C HPLC column. This method can be used to quantitate alginic acid, citric acid or saccharin in complex mixtures. Various detection technique can be used (UV, ELSD, LC/MS), based on mobile phase selection. ...

Lists the various brand names available for medicines containing alginic acid. Find information on alginic acid use, treatment, drug class and molecular formula.

Objective(s): In this study, effects of encapsulated umbilical cord stem cells (UCSCs)-derived hepatocyte-like cells (HLCs) in high mannuronic alginate scaffolds was investigated on CCl4-induced acute liver failure (ALF) in rats. Material and Methods: UCSCs were encapsulated in high mannuronic alginate scaffolds. Then the UCSCs differentiated into HLCs for treatment of CCl4-induced ALF in rats. Thirty rats randomly divided into 5 groups: Intoxicated group received only CCl4 to induce ALF. In other groups including cell-free, UCSCs and HLCs, alginate scaffolds were transplanted into the liver 4 days after CCl4 injection. Biochemical markers including albumin (ALB), blood urea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were evaluated. Histological changes and gene expression of ALB, alpha-fetoprotein (AFP), and cytokeratin 18 (CK-18) were also assessed.Results: Expression of CK-18 significantly increased in HLCs compared to the UCSCs

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Humidity: sunny, mild humidity Using our observations from Experiment #2, we decided to start with a 1:24 ratio of sodium alginate to Future floor polish because this ratio produced a solution with the right combination of fluidity and thickness for a ground.. To begin the experiment we mixed ½ tbs of Sodium alginate and ¾ cup of Zea Mays Stop out to achieve a 1:24 ratio.. This mixture was not fluid like we expected. It immediately started clumping up and became thicker than we anticipated. We hypothesized the different results were due to addition of Gac 100, which is part of the stop out mixture. The Gac 100 was not included in our first test with a 1:24 ratio. In the first test, just future floor polish was mixed with sodium alginate. We let the sodium alginate and stop out mixture sit for three hours to see if over time the clumps would dissolve. After three hours of sitting with periodic stirring, the mixture was still very lumpy and thick. This ratio,1 part sodium alginate to 24 parts ...

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Dolomite Microfluidics systems are enabling reliable, reproducible production of monodisperse alginate beads, overcoming the challenges associated with traditional batch techniques. Controlled and reproducible generation of alginate gel beads is crucial for biomedical science and engineering applications that require biologically and chemically inert polymers, such as the encapsulation of drugs or cells. However, this can be difficult to achieve with batch synthesis, which produces large beads with a wide size distribution and minimal control over bead size. The reproducibility and throughput of the technique are also low. Microfluidic synthesis of alginate beads overcomes these difficulties, allowing precise control of bead formation and enabling rapid production of particles with well-defined sizes, shapes and morphologies ...

Rheumatoid arthritis (RA), a form of inflammatory arthritis, is a chronic joint disease characterized by pain and inflammation that affects 0.5% to 1% of the population worldwide. The safety, efficacy, tolerability, and potency of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property has been reported by several in vitro studies, experimental models and clinical trials phase I/II and III in ankylosing spondylitis and rheumatoid arthritis (RA) patients This research is designed to study the therapeutic efficacy of oral administration of mannuronic acid in RA patients who had inadequate response to conventional drugs and to assess the effect of this drug on gene expression of the signal transducer and activator of transcription (STATs) protein (STAT1, STAT3, STAT4, and STAT6). The study has included 15 RA patients who had an insufficient response to the conventional therapy. The oral dose of mannuronic acid was 1000mg divided into two 500 mg doses per day for 3 months as an ...

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The analysts forecast the global sodium alginate market to exhibit a CAGR of 5.43% during the period 2019-2024. The report covers the present scenario and the growth prospects of the global sodium alginate for 2019-2024. To calculate the market size, the report considers the sodium alginate sales volume and revenue.. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: regional markets, product, and application.. Download Free Sample Report @ https://www.radiantinsights.com/research/sodium-alginate-market/request-sample. Geographically, the global sodium alginate market is segmented into North America, Asia Pacific, Europe, Middle East & Africa and South America. This report forecasts revenue growth at a global, regional & country level, and provides an analysis of the market trends in each of the ...

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SODIUM ALGINATE is part of manufacturing ingredient used in FDA Database. When you consume you prescription drug make sure that you are not allergic to this SODIUM ALGINATE. This will change the way your body absorbs prescription drug your doctor provided you with. SODIUM ALGINATE is used in manufacturing process of pharmaceutical products. List bellow has SODIUM ALGINATE as ingredient during manufacturing.. As some Prescription Drugs might have same name but they are classified by FDA with uniq ID.. ...

The reconstruction of adipose tissue defects is often challenged by the complications that may occur following plastic and reconstructive surgery, including donor-site morbidity, implant migration and foreign body reaction. To overcome these problems, adipose tissue engineering (ATE) using stem cell-based regeneration strategies has been widely explored in the last years. Mounting evidence has shown that adipose-derived stem cells (ADSCs) represent a promising cell source for ATE. In the context of a small number of reports concerning adipose tissue regeneration using three-dimensional (3-D) systems, the present study was designed to evaluate the biological performance of a novel alginate matrix that incorporates human ADSCs (hADSCs). Culture-expanded cells isolated from the stromal vascular fraction (SVF), corresponding to the third passage which showed the expression of mesenchymal stem cell (MSC) markers, were used in the 3-D culture systems. The latter represented a calcium alginate hydrogel,

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Alginic acid, an aa cried algin or alginate, is an anionic polysaccharide distributit widely in the cell walls o broun algae, whaur through bindin wi watter it furms a viscous gum. In extractit furm it absorbs watter quickly; it is capable o absorbin 200-300 times its ain wicht in watter.[1] Its colour ranges frae white tae yellaeish-broun. It is sauld in filamentous, granular or poudered furms.. ...

alginic acid definition: An insoluble colloidal acid by means of a carboxylated polysaccharide thats abundant in the mobile wall space of brown algae.; A gum (a carboxylated polysaccharide), obtained…

In 2018, Top exporters of Polymers, natural and modified natural; in primary forms (excluding alginic acid, its salts and esters) to Malaysia were China ($7,405.93K , 2,809,180 Kg), European Union ($3,725.35K , 428,946 Kg), United States ($2,763.77K , 321,455 Kg), France ($1,509.86K , 41,303 Kg), Italy ($932.94K , 230,380 Kg ...

China exported Polymers, natural and modified natural; in primary forms (excluding alginic acid, its salts and esters) to United States ($93,713.83K , 17,550,500 Kg), Russian Federation ($31,158.16K , 14,335,000 Kg), Germany ($29,060.01K , 4,706,130 Kg), Saudi Arabia ($25,211.82K , 16,195,600 Kg), Japan ($23,263.07K , 1,778,580 Kg ...

More information is available on alginic acid + magaldrate + bicarbonate including side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information.

The characteristic of immobilization technique in alginate gels was described. The environmental factors which determine physiological state of entrapped cells were presented. The possibility of using the system of different yeast strains (coimmobilization) for bioconversion of starch to ethanol was considered. (original abstract ...

Alginate hydrogel made from alginate and crosslinking divalent ions is a natural biomaterial that is biocompatible, has low toxicity, is relatively cheap and has mild gelation chemistry. It is a porous material that allows diffusion of small molecules. Alginate hydrogel is a polymeric network that contains 95-99% water and it does in many ways resemble the natural extracellular matrix (ECM) that surrounds cells in the body. It is also hydrophilic, which reduces friction in body fluids and minimizes protein adsorption and it is easily stored and sterilized.Alginate is produced by both algae and bacteria, and it is initially synthesized as mannuronan (M) with 100% M-residues. Guluronic acid residues (G) are introduced in a post-polymerization step by enzymes called mannuronan C-5 epimerases that catalyze conversion of M into G without breaking the glycosidic bond. Seven different mannuronan C-5 epimerases have been sequenced, cloned and produced recombinantly, and these enzymes introduce ...

Alginate can be produced by a microbial fermentation using bacteria such as Azobacter Vinelandii and Pseudomonas Aeruginosa (Linker and Jones 1964, Gorin and Spencer 1966). These bacteria produce a polysaccharide with a structure resembling alginate, differing only in that there are acetyl groups on a portion of the C2 and C3 hydroxyls. It is believed that the acetate groups are associated mainly with the D-mannuronic acid residues (Davidson 1977, Sutherland 1983, Paul 1986). The level of acetylation is variable as is the mannuronic and guluronic acid content. However the level of guluronic acid in the final polymer can be controlled to some extent by altering the level of calcium in the fermentation broth (Haug and Larsen 1971). The sequence structures and acetylation patterns of bacterial alginate, from different sources, have been studied with 2D COSY proton NMR techniques. The acetyl residues were found to be exclusively associated with the mannuronic acid residues with degrees of ...

Injection of a biomaterial scaffold into the infarcted myocardium can replace the injured extracellular matrix and improve the mechanical strength of the scar. The present study aimed to determine and compare the effect of novel injectable alginate scaffold, with or without staged cardiomyocyte transplantation, with injectable collagen scaffold, or saline on left ventricular (LV) remodeling and function after myocardial infarction (MI) in rat. We developed a novel injectable, absorbable biomaterial composed of a calcium cross-linked alginate solution, which displays low viscosity and undergoes phase transition into hydrogel after injection into the infarct. Rats (n=58) were subjected to anterior MI and subsequently treated with injection of alginate biomaterial (n=22), collagen (n=12), or saline (n=12) into the infarct. One week later, 10 of 22 biomaterial-treated rats and 10 MI rats received rat fetal cardiomyocyte transplantation (1×10 6 cells) into the scar. Hemodynamic studies, performed ...

Sodium and potassium alginate are intended to be used as technological additives (functional groups: emulsifiers, stabilisers, thickeners, gelling agents and binders). Sodium alginate is intended to be used in feedingstuffs for pets, other non food-producing animals and fish, with no maximum recommended use level. Potassium alginate is intended to be used in feedingstuffs for cats and dogs at levels up to 40,000 mg/kg feed (on dry matter). Since the functional properties of the additives are determined by the alginate content, sodium and potassium alginate were considered equivalent. The maximum dose considered safe for cats, dogs, other non food-producing animals, salmonids and other fish is 40,000 mg alginates (sodium and potassium salts)/kg complete feed. The use of alginates in feedingstuffs for fish is of no concern for the consumer. Alginates are reported not to be irritant to the skin but mildly irritant to the eyes. They are considered as potential sensitisers to the skin and the ...

Sodium Alginate (alginate, algin) Molecular RecipesSodium Alginate is a natural polysaccharide product extracted from brown seaweed that grows in cold water regions. In modernist cuisine, sodiu&thickener sodium alginate

|p|KALTOSTAT|sup|®|/sup| Calcium Sodium Alginate dressing is indicated for moderately to highly exuding chronic and acute wounds, and for wounds with minor bleeding.|/p|